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D Menon, S Sukumaran, R Varma, A Radhakrishnan
OBJECTIVES: The presence of obstructive sleep apnea (OSA) has been found to adversely affect the neurological recovery after acute ischemic stroke (AIS) in previous observational studies. However, in most of these studies, diagnosis of OSA was based on oximetry data alone, raising concern in the accuracy of diagnosis as well as estimation of severity. Purpose of our study was to determine the prevalence and severity of OSA (based on polysomnography and American Association of Sleep Medicine [AASM] criteria) in patients with AIS and to compare the post-stroke neurological and functional outcome, in those with and without OSA...
February 15, 2017: Acta Neurologica Scandinavica
Michael Lin, Arun V Krishnan, Danny J Eckert
PURPOSE: The purpose of the present study is to investigate sleep-disordered breathing and symptoms of sleepiness in a consecutive clinical cohort of multiple sclerosis (MS) patients. METHODS: Twenty-one (16 females) community-dwelling adults aged 18-75 years with MS and an Expanded Disability Status Scale score between 2 and 6 were recruited consecutively from an academic teaching hospital MS clinic. Participants performed a home sleep study (ResMed ApneaLink Plus) to objectively quantify sleep-disordered breathing...
December 14, 2016: Sleep & Breathing, Schlaf & Atmung
X P Wang, S J Wang, P Yan, L L Zhu, M Q Li, Z Y Bian, J W Tian
Objective: To explored the effects of lumbar dorsal muscle damage on local lumbar vertebral bone quality. Methods: Thirty SD female rats, at age of 20 weeks, were randomly divided into three groups: control group, or say pseudo surgery group, an incision in the back were performed as CNT; bilateral erector spinal muscle group in which group bilateral lumbar erector spinal muscle were removed as RESM; castration group in which bilateral ovaries were resected as OVX.After three months, bone mineral density, microscopic CT and vertebral compression test were taken in lumbar vertebral (L4-6) in turn...
November 22, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Alison Wimms, Sahisha Ketheeswaran, Claus Ziegenbein, Laura Jennings, Holger Woehrle
Aim. Continuous positive airway pressure (CPAP) masks are a key factor in patient compliance. This program assessed the performance of a new nasal pillows mask (NPM) on a variety of new and established obstructive sleep apnea (OSA) patients using CPAP therapy. Methods. Five programs were developed to assess the new NPM [AirFit P10, ResMed] on naïve patients; patients established on another NPM; patients using a nasal mask; patients with low CPAP compliance; and patients who wished to stop using CPAP therapy...
2016: Sleep Disorders
Christine Eulenburg, Karl Wegscheider, Holger Woehrle, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita K Simonds, Virend K Somers, Faiez Zannad, Helmut Teschler, Martin R Cowie
BACKGROUND: A large randomised treatment trial (SERVE-HF) showed that treatment of central sleep apnoea with adaptive servoventilation in patients with heart failure and reduced ejection fraction (HFREF) increased mortality, although the analysis of the composite primary endpoint (time to first event of death from any cause, life-saving cardiovascular intervention, or unplanned hospital admission for worsening heart failure) was neutral. This secondary multistate modelling analysis of SERVE-HF data investigated associations between adaptive servoventilation and individual components of the primary endpoint to try to better understand the mechanisms underlying the observed increased mortality...
November 2016: Lancet Respiratory Medicine
Grazia Crescimanno, Francesca Greco, Salvo Arrisicato, Noemi Morana, Oreste Marrone
BACKGROUND AND OBJECTIVE: No studies have evaluated the impact of different settings of non-invasive ventilation (NIV) in patients affected by amyotrophic lateral sclerosis (ALS). We explored consequences of positive end-expiratory pressure (PEEP) application on effectiveness of ventilation, sleep architecture and heart rate variability (HRV) in patients with ALS naïve to ventilatory treatment. METHODS: In two consecutive nights, 25 patients received in random order 0 or 4 cm H2 0 of PEEP during nocturnal NIV administration (Idea Ultra ResMed) with the same level of total positive inspiratory pressure...
October 2016: Respirology: Official Journal of the Asian Pacific Society of Respirology
Ulla Anttalainen, Sari Melkko, Sirkka Hakko, Tarja Laitinen, Tarja Saaresranta
PURPOSE: Telemonitoring might enhance continuous positive airway pressure (CPAP) adherence and save nursing time at the commencement of CPAP therapy. We tested wireless telemonitoring (ResTraxx Online System®, ResMed) during the habituation phase of the CPAP therapy in obstructive sleep apnea syndrome (OSAS). METHODS: In total, 111 consecutive OSAS patients were enrolled. After CPAP titration, patients were followed with the telemonitoring (TM, N = 50) or the usual care (UC, N = 61)...
December 2016: Sleep & Breathing, Schlaf & Atmung
Pierre-Charles Neuzeret, Laurent Morin
INTRODUCTION: Patient interface is important for the success of continuous positive airway pressure (CPAP), but few trials have examined the influence of mask choice on CPAP adherence. OBJECTIVES: To compare the impact of different nasal masks on CPAP in patients with newly-diagnosed obstructive sleep apnea (OSA). METHODS: OSA patients were randomized in a 2:3 ratio to receive CPAP via different first-line nasal masks: ResMed Mirage FX® (MFX) or control mask (Fisher & Paykel Zest(®) , HC407(®) or Philips EasyLife(®) )...
January 18, 2016: Clinical Respiratory Journal
Michael Arzt, Holger Woehrle, Olaf Oldenburg, Andrea Graml, Anna Suling, Erland Erdmann, Helmut Teschler, Karl Wegscheider
OBJECTIVES: This prospective study investigated the prevalence of sleep-disordered breathing (SDB) and its predictors in patients with stable chronic heart failure (HF). BACKGROUND: SDB is increasingly recognized as being important in patients with HF. METHODS: The multicenter SchlaHF (Sleep-Disordered Breathing in Heart Failure) registry provides demographic and clinical data on chronic, stable, symptomatic patients with HF (New York Heart Association functional class ≥II; left ventricular rejection fraction ≤45%)...
February 2016: JACC. Heart Failure
Adel Bachour, Pirjo Vitikainen, Paula Maasilta
PURPOSE: Recently, we noticed a considerable development in alleviating problems related to positive airway pressure (PAP) masks. In this study, we report on the initial PAP mask acceptance rates and the effects of mask switching on mask-related symptoms. METHODS: We prospectively collected all cases of mask switching in our sleep unit for a period of 14 months. At the time of the study, we used ResMed™ CPAP devices and masks. Mask switching was defined as replacing a mask used for at least 1 day with another type of mask...
May 2016: Sleep & Breathing, Schlaf & Atmung
Martin R Cowie, Holger Woehrle, Karl Wegscheider, Christiane Angermann, Marie-Pia d'Ortho, Erland Erdmann, Patrick Levy, Anita K Simonds, Virend K Somers, Faiez Zannad, Helmut Teschler
BACKGROUND: Central sleep apnea is associated with poor prognosis and death in patients with heart failure. Adaptive servo-ventilation is a therapy that uses a noninvasive ventilator to treat central sleep apnea by delivering servo-controlled inspiratory pressure support on top of expiratory positive airway pressure. We investigated the effects of adaptive servo-ventilation in patients who had heart failure with reduced ejection fraction and predominantly central sleep apnea. METHODS: We randomly assigned 1325 patients with a left ventricular ejection fraction of 45% or less, an apnea-hypopnea index (AHI) of 15 or more events (occurrences of apnea or hypopnea) per hour, and a predominance of central events to receive guideline-based medical treatment with adaptive servo-ventilation or guideline-based medical treatment alone (control)...
September 17, 2015: New England Journal of Medicine
Puhong Zhang, Rui Zhang, Fang Zhao, Emma Heeley, Ching L Chai-Coetzer, Jing Liu, Bo Jing, Ping Han, Qifu Li, Liao Sun, Yufeng Li, Shengying Dong, Xiaozhen Jiang, Chunhua Zhang, Jinhui Lu, Xingduan Guo, Lixin Guo, R Doug Mcevoy, Linong Ji
Data on the prevalence of obstructive sleep apnea in subjects with type 2 diabetes mellitus in China is scarce. We conducted a multi-centre, cross-sectional study involving 12 hospitals from six regional cities to investigate the prevalence of obstructive sleep apnea in hospitalized patients with type 2 diabetes mellitus and to explore the association between obstructive sleep apnea and related risk factors, diabetic complications and comorbidities in China. Each hospital recruited at least 70 consecutive patients with type 2 diabetes mellitus who were admitted to the endocrinology ward...
February 2016: Journal of Sleep Research
E Luchnikova, V Shchekotov
OBJECTIVE: To determine of visceral fat level (VFL) can be used as the obstructive sleep apnea syndrome (OSAS) severity predictor. To compare the diagnostic value of visceral fat determination and other anthropometric data and indexes. DESIGN AND METHOD: The study involved 62 patients (26 women and 36 men) mean aged 52.78 ± 10.69 years with the II-III stage of arterial hypertension, 1-3 degrees. The first group included 22 patients with mild OSAS (apnea-hypopnea index (AHI) < 15), the second - 40 patient with moderate and severe OSA (AHI = 15 and AHI > 15)...
June 2015: Journal of Hypertension
Nigel McArdle, Stuart King, Kelly Shepherd, Vanessa Baker, Dinesh Ramanan, Sahisha Ketheeswaran, Peter Bateman, Alison Wimms, Jeff Armitstead, Glenn Richards, David Hillman, Peter Eastwood
STUDY OBJECTIVES: To assess the efficacy of a novel female-specific autotitrating continuous positive airway pressure (CPAP) algorithm (AutoSet for her, AfH) in premenopausal women relative to a standard autotitrating algorithm (AutoSet, S9) (ResMed Ltd., Bella Vista, New South Wales, Australia). DESIGN: Prospective randomised crossover noninferiority trial. SETTING: Tertiary hospital sleep clinic and university research sleep laboratory. PARTICIPANTS: 20 female patients with obstructive sleep apnea (OSA) established on long-term CPAP treatment...
November 1, 2015: Sleep
Jens Spießhöfer, Jessica Heinrich, Roman Lehmann, Christina Efken, Henrik Fox, Thomas Bitter, Britta Körber, Dieter Horstkotte, Olaf Oldenburg
BACKGROUND: Nocturnal adaptive servoventilation (ASV) therapy is now frequently used to treat Cheyne-Stokes respiration (CSR), which is highly prevalent in patients with moderate-to-severe heart failure (HF) and characterized by periodical breathing (hyperventilation). OBJECTIVES: This study analyzed and compared the acute effects of a novel ASV device on carbon dioxide pressure (pCO2) and oxygen saturation (SaO2) in HF patients with CSR and healthy volunteers. The influence of being asleep or awake on the ASV algorithm was also determined...
2015: Respiration; International Review of Thoracic Diseases
Olaf Oldenburg, Jens Spießhöfer, Henrik Fox, Natalie Prib, Dieter Horstkotte
PURPOSE: Adaptive servo-ventilation (ASV) is a positive pressure ventilator support system to normalize ventilation in patients with Cheyne-Stokes respiration (CSR). The latest generation enhanced ASV device (PaceWave; ResMed) has a new feature--auto-adjustment of EPAP. This study tested the hypothesis that enhanced ASV with auto-adjustment of EPAP (PaceWave) is non-inferior to conventional ASV (AutoSetCS). METHODS: This prospective, randomized, crossover, single-center study enrolled adult patients with stable heart failure (HF) and moderate-to-severe sleep-disordered breathing (SDB) who had been receiving conventional ASV therapy for at least 4 weeks...
September 2015: Sleep & Breathing, Schlaf & Atmung
R Nisha Aurora, Rachel Swartz, Naresh M Punjabi
BACKGROUND: The advent of home sleep testing has allowed for the development of an ambulatory care model for OSA that most health-care providers can easily deploy. Although automated algorithms that accompany home sleep monitors can identify and classify disordered breathing events, it is unclear whether manual scoring followed by expert review of home sleep recordings is of any value. Thus, this study examined the agreement between automated and manual scoring of home sleep recordings...
March 2015: Chest
C Medrinal, G Prieur, O Contal, E Villiot-Danger, C Doyle, G Reychler, J Quieffin
BACKGROUND: Many types of interfaces with intentional leaks exist for Non Invasive Ventilation. The purpose of intentional leaks is to remove CO2 from the interface, however the calibration does not allow a sufficiently large flow and rebreathing of CO2 can occur. The aim of this study was to compare the CO2 rinsing capacities of three new generation oronasal masks with intentional leaks (A: Quattro®, [Resmed]; B: Amara® [Respironics]; C: Forma® [Fisher&Paykel]) in healthy subjects...
May 2015: Minerva Anestesiologica
Clete A Kushida, Ann C Halbower, Meir H Kryger, Rafael Pelayo, Valerie Assalone, Chia-Yu Cardell, Stephanie Huston, Leslee Willes, Alison J Wimms, June Mendoza
STUDY OBJECTIVES: The choice and variety of pediatric masks for continuous positive airway pressure (CPAP) is limited in the US. Therefore, clinicians often prescribe modified adult masks. Until recently a mask for children aged < 7 years was not available. This study evaluated apnea-hypopnea index (AHI) equivalence and acceptability of a new pediatric CPAP mask for children aged 2-7 years (Pixi; ResMed Ltd, Sydney, Australia). METHODS: Patients aged 2-7 years were enrolled and underwent in-lab baseline polysomnography (PSG) using their previous mask, then used their previous mask and the VPAP III ST-A flow generator for ≥ 10 nights at home...
September 15, 2014: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Thomas Köhnlein, Wolfram Windisch, Dieter Köhler, Anna Drabik, Jens Geiseler, Sylvia Hartl, Ortrud Karg, Gerhard Laier-Groeneveld, Stefano Nava, Bernd Schönhofer, Bernd Schucher, Karl Wegscheider, Carl P Criée, Tobias Welte
BACKGROUND: Evidence is weak for the ability of long-term non-invasive positive pressure ventilation (NPPV) to improve survival in patients with stable hypercapnic chronic obstructive pulmonary disease (COPD). Previous prospective studies did not target a reduction in hypercapnia when adjusting ventilator settings. This study investigated the effect of long-term NPPV, targeted to markedly reduce hypercapnia, on survival in patients with advanced, stable hypercapnic COPD. METHODS: This investigator-initiated, prospective, multicentre, randomised, controlled clinical trial enrolled patients with stable GOLD stage IV COPD and a partial carbon dioxide pressure (PaCO2) of 7 kPa (51...
September 2014: Lancet Respiratory Medicine
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