Caryn E Plummer, Timothy Polk, Jatin Sharma, Sanghyo Sarah Bae, Olivia Barr, Amari Jones, Holly Kitchen, Michelle Wilhelmy, K Devin, W Clay Smith, Bryan D Kolaczkowski, Joseph Larkin
Equine recurrent uveitis (ERU) is a painful and debilitating autoimmune disease and represents the only spontaneous model of human recurrent uveitis (RU). Despite the efficacy of existing treatments, RU remains a leading cause of visual handicap in horses and humans. Cytokines, which utilize Janus kinase 2 (Jak2) for signaling, drive the inflammatory processes in ERU that promote blindness. Notably, suppressor of cytokine signaling 1 (SOCS1), which naturally limits the activation of Jak2 through binding interactions, is often deficient in autoimmune disease patients...
May 3, 2022: Scientific Reports