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Equine recurrent uveitis

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https://www.readbyqxmd.com/read/27863549/cytokine-and-chemokine-profiles-of-aqueous-humor-and-serum-in-horses-with-uveitis-measured-using-multiplex-bead-immunoassay-analysis
#1
Elizabeth Curto, Kristen M Messenger, Jacklyn H Salmon, Brian C Gilger
OBJECTIVE: To determine whether horses with clinically diagnosed Equine Recurrent Uveitis (ERU) and those with Leptospirosis infection have a specific cytokine profile in their aqueous humor (AH) and serum that differs from horses with uveitis secondary to other ocular inflammatory processes and from horses with normal eyes. ANIMALS STUDIED: Twenty-five client-owned horses with uveitis that were presented to the North Carolina State University Ophthalmology Service, and four University-owned horses without history or clinical signs of ocular disease...
December 2016: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/27836047/a-study-of-leptospirosis-in-south-african-horses-and-associated-risk-factors
#2
V Simbizi, M N Saulez, A Potts, C Lötter, B Gummow
Most leptospiral infections in horses are asymptomatic; however, acute disease manifestations as well as reproductive failure and recurrent uveitis have been reported. In South Africa, the epidemiology of the disease in horses is not well documented. A serosurvey to determine what serovars were present in horses from Gauteng, KwaZulu-Natal and Western Cape Provinces and to get an estimate of the seroprevalence of leptospirosis was carried out from January 2013 until April 2014 with the assistance of four large equine hospitals located in these provinces...
November 1, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27571017/immunological-characterization-of-intraocular-lymphoid-follicles-in-a-spontaneous-recurrent-uveitis-model
#3
Kristina J H Kleinwort, Barbara Amann, Stefanie M Hauck, Regina Feederle, Walter Sekundo, Cornelia A Deeg
PURPOSE: Recently, formation of tertiary lymphoid structures was demonstrated and further characterized in the R161H mouse model of spontaneous autoimmune uveitis. In the horse model of spontaneous recurrent uveitis, intraocular lymphoid follicle formation is highly characteristic, and found in all stages and scores of disease, but in depth analyses of immunologic features of these structures are lacking to date. METHODS: Paraffin-embedded eye sections of cases with equine spontaneous recurrent uveitis (ERU) were characterized with immunohistochemistry to gain insight into the distribution, localization, and signaling of immune cells in intraocular tertiary lymphoid tissues...
August 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27344913/-detection-of-leptospira-by-culture-of-vitreous-humor-and-detection-of-antibodies-against-leptospira-in-vitreous-humor-and-serum-of-225-horses-with-equine-recurrent-uveitis
#4
Elisa Dorrego-Keiter, József Tóth, Lieke Dikker, Jutta Sielhorst, Gerald Fritz Schusser
In the ongoing discussion regarding the aetiopathogenesis of equine recurrent uveitis (ERU) it was the aim of the present study to elucidate the relationship of leptospira infection and ERU. In a population of 225 horses leptospira were examined in vitreous humor by culture and leptospira antibody were detected in vitreous humor and serum samples. Preoperative serum samples were collected from 221/225 ERU patients of different age, gender and breed. Undiluted vitreous humor was aseptically taken from 198/225 patients that underwent pars plana vitrectomy at the beginning of surgery and from 27/225 patients' eyeball after enucleation: Serum and vitreous humor were tested for specific leptospiral antibodies by microscopic agglutination test (MAT)...
May 2016: Berliner und Münchener Tierärztliche Wochenschrift
https://www.readbyqxmd.com/read/27344152/immunological-and-pathological-investigations-in-equine-experimental-uveitis
#5
Galina P Simeonova, Svetozar Z Krastev, Radostin S Simeonov
BACKGROUND: The pathogenic mechanism of equine recurrent uveitis (ERU) is still poorly defined and many variations between experimental animal models and spontaneous disease exist. OBJECTIVES: The aim of our study was to investigate if Th17 cell-mediated response plays role in the pathogenesis of the used experimental model in horses and to reveal its pathological findings. METHODS: Experimental uveitis was induced in 6 healthy horses. The concentrations of retinal autoantigen CRALBP and IL-17 were measured using ELISA in aqueous humor and vitreous body of the 12 inflamed eyes as well as in 12 control non-inflamed eyes taken from 6 horses in slaughter house...
June 25, 2016: Veterinary Research Communications
https://www.readbyqxmd.com/read/26851589/multiple-etiologies-of-equine-recurrent-uveitis-a-natural-model-for-human-autoimmune-uveitis-a-brief-review
#6
REVIEW
Lucjan Witkowski, Anna Cywinska, Katarzyna Paschalis-Trela, Mark Crisman, Jerzy Kita
Equine recurrent uveitis (ERU) has various etiologies, with Leptospira infection and genetic predisposition being the leading risk factors. Regardless of etiology, expression of ocular proteins associated with maintenance of the blood-ocular barrier is impaired in ERU. The recurring-remitting cycle of ERU repeatedly disrupts the blood-ocular barrier, allowing the previously immune-privileged ocular environment to become the site of a progressive local autoimmune pathology that ultimately results in tissue destruction and vision loss...
February 2016: Comparative Immunology, Microbiology and Infectious Diseases
https://www.readbyqxmd.com/read/26773714/comparison-of-corneal-degeneration-and-calcific-band-keratopathy-from-2000-to-2013-in-69-horses
#7
Emily H Berryhill, Sara M Thomasy, Philip H Kass, Christopher M Reilly, Kathryn L Good, Steven R Hollingsworth, David J Maggs, K Gary Magdesian, Nicola Pusterla
OBJECTIVE: To compare signalment, presentation, treatment, and outcome in horses diagnosed with corneal degeneration (CD) or calcific band keratopathy (CBK) at a referral hospital. ANIMALS STUDIED: Sixty-nine horses (87 eyes) diagnosed with either CD or CBK. PROCEDURES: Medical records of horses diagnosed with CD or CBK at the University of California-Davis Veterinary Medical Teaching Hospital (UCD-VMTH) between 2000 and 2013 were reviewed...
January 15, 2016: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/26211968/presence-of-leptospires-on-genital-tract-of-mares-with-reproductive-problems
#8
Camila Hamond, Cristiane P Pestana, Cláudio Marcos Rocha-de-Souza, Luis Eduardo R Cunha, Felipe Z Brandão, Marco Alberto Medeiros, Walter Lilenbaum
Leptospirosis is a zoonotic disease of global importance, and has a worldwide distribution. Equine leptospirosis is commonly manifested by recurrent uveitis, reproductive disorders, as abortions, embryonic absorption, stillbirth and the birth of weak foals. The aim of this study was to verify the presence of Leptospira sp or its DNA in genital tract of mares with reproductive problems. A total of 38 mares with reproductive problems were studied. All the mares were sampled for blood (for serology), urine (for culturing and qPCR), vaginal fluid-VF and endometrial biopsy-EB (for culturing, qPCR and indirect immunofluorescence)...
September 30, 2015: Veterinary Microbiology
https://www.readbyqxmd.com/read/26188862/equine-recurrent-uveitis-human-and-equine-perspectives
#9
REVIEW
Fernando Malalana, Amira Stylianides, Catherine McGowan
Equine recurrent uveitis (ERU) is a spontaneous disease characterised by repeated episodes of intraocular inflammation. The epidemiology of ERU has not been fully elucidated, but the condition appears to be much more common in horses than is recurrent uveitis in humans, especially in certain breeds and geographical regions. Both humans and horses show a similarly altered immune response and a marked autoimmune response as the primary disease pathophysiology. However, an inciting cause is not always clear. Potential inciting factors in horses include microbial agents such as Leptospira spp...
October 2015: Veterinary Journal
https://www.readbyqxmd.com/read/25891653/prognosis-and-impact-of-equine-recurrent-uveitis
#10
J C Gerding, B C Gilger
REASONS FOR PERFORMING STUDY: Equine recurrent uveitis (ERU) is a leading cause of vision loss in horses. OBJECTIVES: To assess the prognosis and impact of ERU on affected horses and their owners by evaluating the signalment, treatment and outcome (including the loss of use, vision assessment and economic loss). STUDY DESIGN: Retrospective impact study. METHODS: Medical records of horses presenting to the North Carolina State University Veterinary Health Complex (NCSU-VHC) with ERU between 1999 and 2014 were reviewed...
May 2016: Equine Veterinary Journal
https://www.readbyqxmd.com/read/25629227/novel-localization-of-peripherin-2-the-photoreceptor-specific-retinal-degeneration-slow-protein-in-retinal-pigment-epithelium
#11
Patrizia B Uhl, Barbara Amann, Stefanie M Hauck, Cornelia A Deeg
Retinal pigment epithelium (RPE) builds the outer blood-retinal barrier of the eye. Since one typical feature of the autoimmune disease, equine recurrent uveitis (ERU), is the breakdown of this barrier, we recently performed comparative analysis of healthy and uveitic RPE. We identified for the first time peripherin 2, which is responsible for visual perception and retina development, to be localized in RPE. The purpose of this study was therefore to validate our findings by characterizing the expression patterns of peripherin 2 in RPE and retina...
2015: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/24998980/in-situ-cell-surface-proteomics-reveals-differentially-expressed-membrane-proteins-in-retinal-pigment-epithelial-cells-during-autoimmune-uveitis
#12
P B Uhl, C M Szober, B Amann, C Alge-Priglinger, M Ueffing, S M Hauck, C A Deeg
UNLABELLED: Retinal pigment epithelium (RPE) builds the outer blood-retinal barrier of the eye and plays an important role in pathogenesis of the sight threatening disease equine recurrent uveitis (ERU). ERU is a spontaneous autoimmune mediated inflammatory disease characterised by the breakdown of the outer blood-retinal barrier and an influx of autoaggressive T-cells into the inner eye. Therefore, identification of molecular mechanisms contributing to changed function of blood-retinal barrier in ERU is important for the understanding of pathophysiology...
September 23, 2014: Journal of Proteomics
https://www.readbyqxmd.com/read/24975895/characterization-of-amyloid-in-equine-recurrent-uveitis-as-aa-amyloid
#13
L Ostevik, G A de Souza, T N Wien, G Gunnes, R Sørby
Two horses with chronic uveitis and histological lesions consistent with equine recurrent uveitis (ERU) were examined. Microscopical findings in the ciliary body included deposits of amyloid lining the non-pigmented epithelium, intracytoplasmic, rod-shaped, eosinophilic inclusions and intraepithelial infiltration of T lymphocytes. Ultrastructural examination of the ciliary body of one horse confirmed the presence of abundant extracellular deposits of non-branching fibrils (9-11 nm in diameter) consistent with amyloid...
August 2014: Journal of Comparative Pathology
https://www.readbyqxmd.com/read/24774226/visual-outcomes-of-phacoemulsification-cataract-surgery-in-horses-1990-2013
#14
Dennis E Brooks, Caryn E Plummer, Susan M Carastro, Mary E Utter
OBJECTIVE: To evaluate the long-term visual outcome of phacoemulsification lens extraction surgery in foals and horses and identify any unique postoperative complications that affect the visual outcome. PROCEDURE: This is a retrospective medical records study of phacoemulsification cataract surgery in 95 foals and horses from 1990 to 2013. RESULTS: Cataracts were removed by phacoemulsification from 111 eyes of 95 horses ranging in age from 22 days to 26 years (average 8...
July 2014: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/24614191/unraveling-the-equine-lymphocyte-proteome-differential-septin-7-expression-associates-with-immune-cells-in-equine-recurrent-uveitis
#15
Roxane L Degroote, Stefanie M Hauck, Barbara Amann, Sieglinde Hirmer, Marius Ueffing, Cornelia A Deeg
Equine recurrent uveitis is a spontaneous, lymphocyte-driven autoimmune disease. It affects horses worldwide and presents with painful remitting-relapsing inflammatory attacks of inner eye structures eventually leading to blindness. Since lymphocytes are the key players in equine recurrent uveitis, we were interested in potential changes of their protein repertoire which may be involved in disease pathogenesis. To create a reference for differential proteome analysis, we first unraveled the equine lymphocyte proteome by two-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis and subsequently identified 352 protein spots...
2014: PloS One
https://www.readbyqxmd.com/read/24467435/genetic-risk-factors-for-insidious-equine-recurrent-uveitis-in-appaloosa-horses
#16
K L Fritz, H J Kaese, S J Valberg, J A Hendrickson, A K Rendahl, R R Bellone, K M Dynes, M L Wagner, M A Lucio, F M Cuomo, C L Brinkmeyer-Langford, L C Skow, J R Mickelson, M S Rutherford, M E McCue
Appaloosa horses are predisposed to equine recurrent uveitis (ERU), an immune-mediated disease characterized by recurring inflammation of the uveal tract in the eye, which is the leading cause of blindness in horses. Nine genetic markers from the ECA1 region responsible for the spotted coat color of Appaloosa horses, and 13 microsatellites spanning the equine major histocompatibility complex (ELA) on ECA20, were evaluated for association with ERU in a group of 53 Appaloosa ERU cases and 43 healthy Appaloosa controls...
June 2014: Animal Genetics
https://www.readbyqxmd.com/read/24144192/expression-changes-and-novel-interaction-partners-of-talin-1-in-effector-cells-of-autoimmune-uveitis
#17
Roxane L Degroote, Stefanie M Hauck, Gudrun Treutlein, Barbara Amann, Kristina J H Fröhlich, Elisabeth Kremmer, Juliane Merl, Manfred Stangassinger, Marius Ueffing, Cornelia A Deeg
Autoimmune uveitis is characterized by crossing of blood-retinal barrier (BRB) by autoaggressive immune cells. Equine recurrent uveitis (ERU) is a valuable spontaneous model for autoimmune uveitis and analyses of differentially expressed proteins in ERU unraveled changed protein clusters in target tissues and immune system. Healthy eyes are devoid of leukocytes. In ERU, however, leukocytes enter the inner eye and subsequently destroy it. Molecular mechanisms enabling cell migration through BRB still remain elusive...
December 6, 2013: Journal of Proteome Research
https://www.readbyqxmd.com/read/24059262/identification-of-autoantigens-in-body-fluids-by-combining-pull-downs-and-organic-precipitations-of-intact-immune-complexes-with-quantitative-label-free-mass-spectrometry
#18
Juliane Merl, Cornelia A Deeg, Margarete E Swadzba, Marius Ueffing, Stefanie M Hauck
Most autoimmune diseases are multifactorial diseases and are caused by the immunological reaction against a number of autoantigens. Key for understanding autoimmune pathologies is the knowledge of the targeted autoantigens, both initially and during disease progression. We present an approach for autoantigen identification based on isolation of intact autoantibody-antigen complexes from body fluids. After organic precipitation of high molecular weight proteins and free immunoglobulins, released autoantigens were identified by quantitative label-free liquid chromatography mass spectrometry...
December 6, 2013: Journal of Proteome Research
https://www.readbyqxmd.com/read/23977091/a-genome-wide-association-study-identifies-risk-loci-to-equine-recurrent-uveitis-in-german-warmblood-horses
#19
Maike Kulbrock, Stefanie Lehner, Julia Metzger, Bernhard Ohnesorge, Ottmar Distl
Equine recurrent uveitis (ERU) is a common eye disease affecting up to 3-15% of the horse population. A genome-wide association study (GWAS) using the Illumina equine SNP50 bead chip was performed to identify loci conferring risk to ERU. The sample included a total of 144 German warmblood horses. A GWAS showed a significant single nucleotide polymorphism (SNP) on horse chromosome (ECA) 20 at 49.3 Mb, with IL-17A and IL-17F being the closest genes. This locus explained a fraction of 23% of the phenotypic variance for ERU...
2013: PloS One
https://www.readbyqxmd.com/read/23647816/leptospirosis-in-horses
#20
REVIEW
Ashutosh Verma, Brian Stevenson, Ben Adler
Leptospirosis in horses has been considered a relatively uncommon infection. However, recent data suggest that the infection is widespread, with the incidence and infecting serovars varying considerably in different geographical regions. The majority of infections remain asymptomatic. Clinical signs in equine leptospirosis resemble those seen in other animal species. However, leptospirosis as a cause of acute respiratory distress is becoming more frequently recognised. A particular feature of equine leptospirosis is post infection recurrent uveitis (moon blindness or periodic ophthalmia), which appears to be mediated by autoimmune mechanisms involving cross reactivity between ocular tissues and leptospiral membrane proteins...
November 29, 2013: Veterinary Microbiology
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