Gregory E Simon, Rebecca C Rossom, Esti Iturralde, Brian K Ahmedani, Stephen C Waring, Ashli A Owen-Smith, Stacy A Sterling, Kathleen Miley, Cheryl D Stults, Yihe G Daida, Frances L Lynch, Arne Beck, Katherine Sanchez, Karen J Coleman, Susan M Shortreed
Objective: To examine rates of clozapine use among people with psychotic disorders who experience specific indications for clozapine. Methods: Records data from 11 integrated health systems identified patients aged 18 years or older with recorded International Classification of Diseases, Tenth Revision, Clinical Modification , diagnoses of schizophrenia, schizoaffective disorder, or other psychotic disorder who experienced any of the 3 events between January 1, 2019, and December 31, 2019, suggesting indications for clozapine: a diagnosis of self-harm injury or poisoning, suicidal ideation diagnosed or in response to standardized assessments, and hospitalization or emergency department (ED) care for psychotic disorder despite treatment with 2 or more antipsychotic medications...
April 29, 2024: Journal of Clinical Psychiatry