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Oncohematology

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https://www.readbyqxmd.com/read/28151510/-let-me-tell-you-about-my-little-box-phenomenological-study-on-the-experience-of-living-with-a-totally-implantable-central-venous-catheter
#1
Carolina Mutti, Anna Fumagalli, Pierina Monni, Stefania Rancati, Ivana Maria Rosi
: . "Let me tell you about my little box": phenomenological study on the experience of living with a totally implantable central venous catheter. INTRODUCTION: Many variables impact on the choice to implant a totally implantable long-term central venous catheter's (Port), in spite of its proven efficacy. The patients' perception is pivotal, and only few qualitative studies dig deep into patients' feelings and experiences. AIMS: To understand if, and how, the Port affects the patient's life...
October 2016: Assistenza Infermieristica e Ricerca: AIR
https://www.readbyqxmd.com/read/28063519/comparison-of-two-nutritional-screening-tools-to-detect-nutritional-risk-in-hematologic-inpatients
#2
Lucía Fiol-Martínez, Alicia Calleja-Fernández, Begoña Pintor de la Maza, Alfonso Vidal-Casariego, Rocío Villar-Taibo, Ana Urioste-Fondo, Marta Cuervo, Isidoro Cano-Rodríguez, María D Ballesteros-Pomar
OBJECTIVE: The aim of the study was to compare two nutritional screening tools in oncohematologic inpatients. METHODS: A cross-sectional study was performed in a hematology ward from August to December 2015. Within the first 24 h of admission, the following nutritional screenings were performed: Malnutrition Universal Screening Tool (MUST), Malnutrition Screening Tool (MST), and Subjective Global Assessment (SGA). Patients who stayed in the hematologic ward were reevaluated with the three screening tools 1 and 2 wk after admission...
February 2017: Nutrition
https://www.readbyqxmd.com/read/28013412/the-inhibition-of-voltage-gated-h-channel-hvcn1-induces-acidification-of-leukemic-jurkat-t-cells-promoting-cell-death-by-apoptosis
#3
Agustín Asuaje, Paola Smaldini, Pedro Martín, Nicolás Enrique, Alejandro Orlowski, Ernesto A Aiello, Carlos Gonzalez León, Guillermo Docena, Verónica Milesi
Cellular energetic deregulation is widely known to produce an overproduction of acidic species in cancer cells. This acid overload must be counterbalanced with a high rate of H(+) extrusion to maintain cell viability. In this sense, many H(+) transporters have been reported to be crucial for cell survival and proposed as antineoplastic target. By the way, voltage-gated proton channels (Hv1) mediate highly selective H(+) outward currents, capable to compensate acid burden in brief periods of time. This structure is canonically described acting as NADPH oxidase counterbalance in reactive oxygen species production...
December 24, 2016: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28000464/a-short-nutritional-intervention-in-a-cohort-of-hematological-inpatients-improves-energy-and-protein-intake-and-stabilizes-nutritional-status
#4
Rocío Villar-Taibo, Alicia Calleja-Fernández, Alfonso Vidal-Casariego, Begoña Pintor-de-la-Maza, Cecilia Álvarez-Del-Campo, Rosa Arias-García, Isidoro Cano-Rodríguez, María D Ballesteros-Pomar
INTRODUCTION: Oncohematological diseases are associated with an important prevalence of malnutrition. AIM: Our aim is to determine if early recognition and treatment of malnourished hematological inpatients can improve their oral intake, nutritional status and reduce the length of hospital stay. METHODS: Prospective 2-year study conducted in a cohort of hematology inpatients. Malnutrition Screening Tool (MST) was carried out on the first day of admission...
November 29, 2016: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/27981789/comparison-of-abnormal-cell-flagging-of-the-hematology-analyzers-sysmex-xn-and-sysmex-xe-5000-in-oncohematologic-patients
#5
J R Furundarena, M Sainz, A Uranga, L Cuevas, I Lopez, J Zubicaray, A Bizjak, N Robado, M Araiz
INTRODUCTION: Hematology analyzers should optimize flagging while minimizing false-negative results and unnecessary microscopic reviews. METHODS: We compared flagging performance of Sysmex XE-5000 and XN analyzers in oncohematologic patients. Differential counts were performed by Cellavision digital system (100 cells) and a hematologist (another 100 cells). RESULTS: First, we included 292 samples (86 with blasts): 28 acute lymphoblastic leukemia, 88 acute myeloid leukemia, 91 myelodysplastic syndromes, 45 chronic myeloproliferative neoplasms, and 40 chronic myelomonocytic leukemia...
February 2017: International Journal of Laboratory Hematology
https://www.readbyqxmd.com/read/27933487/evaluation-of-standardized-triple-intrathecal-therapy-toxicity-in-oncohematological-pediatric-patients
#6
Raquel Olmos-Jiménez, María Sacramento Díaz-Carrasco, Ana Galera-Miñarro, Juan Francisco Pascual-Gazquez, Alberto Espuny-Miró
Background The administration of triple intrathecal therapy with methotrexate, cytarabine and a corticosteroid for the prophylaxis and treatment of neoplastic cell infiltration in the central nervous system in hematological malignancies is a widespread practice. There is limited information available about its toxicity profile. Several factors related to intrathecal preparation can affect toxicity. Thus, it was decided to standardize intrathecal chemotherapy, trying to obtain the best toxicity profile. Objective To assess the toxicity of a standardized triple intrathecal chemotherapy in oncohematological pediatric patients and to establish risk factors of toxicity...
February 2017: International Journal of Clinical Pharmacy
https://www.readbyqxmd.com/read/27928093/imported-disease-screening-prior-to-chemotherapy-and-bone-marrow-transplantation-for-oncohematological-malignancies
#7
Adrián Sánchez-Montalvá, Fernando Salvador, Isabel Ruiz-Camps, Pere Barba, David Valcárcel, Elena Sulleiro, Enrique Sanz-García, Israel Molina
Reactivation of latent imported infections has been periodically reported in migrant patients undergoing immunosuppression. We performed a prospective study at Vall d'Hebron University Hospital (Barcelona, Spain). Migrant patients over 16 years with the diagnosis of any oncohematologic disease were included. Patients were tested for soil-transmitted helminths, hepatitis virus, and human immunodeficiency virus, Treponema pallidum, human T-cell lymphotropic virus, latent tuberculosis infection, Toxoplasma spp...
December 7, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27904738/recent-developments-in-the-management-of-invasive-fungal-infections-in-patients-with-oncohematological-diseases
#8
REVIEW
Markus Ruhnke, Stefan Schwartz
Patients with hematological cancer have a high risk of invasive fungal diseases (IFDs). These infections are mostly life threatening and an early diagnosis and initiation of appropriate antifungal therapy are essential for the clinical outcome. Most commonly, Aspergillus and Candida species are involved. However, other non-Aspergillus molds are increasingly be identified in cases of documented IFDs. Important risk factors are long lasting granulocytopenia with neutrophil counts below 500/μl for more than 10 days or graft-versus-host disease resulting from allogeneic stem-cell transplantation...
December 2016: Therapeutic Advances in Hematology
https://www.readbyqxmd.com/read/27845483/prevalence-of-pain-in-the-departments-of-surgery-and-oncohematology-of-a-paediatric-hospital-that-has-joined-the-project-towards-pain-free-hospital
#9
G Marchetti, A Vittori, V Tortora, M Bishop, G Lofino, V Pardi, E A De Marco, G Manca, A Inserra, R Caruso, I Ciaralli, F Locatelli, S Bella, A E Tozzi, S Picardo
BACKGROUND: Among hospitalized adults and children pain is undertreated. This study wants to assess the effectiveness of pain therapy in two departments of a large children's hospital. MATERIALS AND METHODS: During a single day work three committees, administering a questionnaire to patients or parents, have evaluated the adherence to international recommendations (JCI and WHO) in the management of analgesic therapy. Patient demographics, prevalence and intensity (moderate and/or severe) of pain (during hospitalization, 24 hours before and at the time of the interview), analgesia (type, route, duration and frequency of administration) and Pain Management Index (=analgesic score-pain score) were recorded...
September 2016: La Clinica Terapeutica
https://www.readbyqxmd.com/read/27777882/cigarette-smoking-dietary-habits-and-genetic-polymorphisms-in-gstt1-gstm1-and-cyp1a1-metabolic-genes-a-case-control-study-in-oncohematological-diseases
#10
María Belén Cerliani, Walter Pavicic, Juan Antonio Gili, Graciela Klein, Silvia Saba, Silvina Richard
AIM: To analyze the association between oncohematological diseases and GSTT1/GSTM1/CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospital-based case-control study. METHODS: This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods...
October 10, 2016: World Journal of Clinical Oncology
https://www.readbyqxmd.com/read/27737428/to-admission-factors-associated-with-intensive-care-unit-readmission-in-critically-ill-oncohematological-patients-a-retrospective-cohort-study
#11
Müge Aydoğdu, Antonio M Esquinas
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27737417/reply-to-admission-factors-associated-with-intensive-care-unit-readmission-in-critically-ill-oncohematological-patients-a-retrospective-cohort-study
#12
Cinthia Mendes Rodrigues, Ellen Maria Campos Pires, Jorge Patrick Oliveira Feliciano, Jose Mauro Vieira, Leandro Utino Taniguchi
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/27713885/the-immunocompromised-oncohematological-critically-ill-patient-considerations-in-severe-infections
#13
REVIEW
Belén Encina, Leonel Lagunes, Marc Morales-Codina
Sepsis and septic shock remain a major cause of mortality among critically ill patient. This is particularly relevant among cancer patients as highlighted by different series showing that up to one in five patients admitted to intensive care units (ICU) with sepsis have cancer, and also, sepsis is a leading reason for ICU admission in patients with cancer. The classic predictors of mortality among these patients (such as cancer lineage, neutropenia degree, or bone marrow transplantation history) have changed during the last decades, and they should no longer be used to rule out ICU admission...
September 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27707677/verification-of-a-quantitative-method-complete-blood-count-by-flow-cytometry-the-hematoflow-tm-system-beckman-coulter
#14
Inès Vergnolle, Kaoutar Allou, Francis Lacombe, François Xavier Mahon, Jean-Philippe Vial
The HematoFlow™ system is used in the hematology laboratory of the University Hospital of Bordeaux since July, 2011. The HematoFlow™ solution is the combination of a sample preparator (FP1000) and a 5 color flow cytometer (FC500) linked by a middleware (Remisol™). This system is used in second line when flags are activated by the hematology instrument and/or if the sample comes from the OncoHematology Department. Improvements in hematology disease diagnosis and follow-up were possible using this system...
October 1, 2016: Annales de Biologie Clinique
https://www.readbyqxmd.com/read/27596510/-literature-review-and-presentation-of-our-own-research-results-regarding-the-effects-on-bone-of-tyrosine-kinase-inhibitors-imatinib-and-nilotinib-used-in-the-treatment-of-oncohematological-diseases
#15
Gyöngyi Kirschner, Bernadett Balla, János Kósa, Péter Horváth, Andrea Kövesdi, Gergely Lakatos, István Takács, Zsolt Nagy, Bálint Tóbiás, Kristóf Árvai, Péter Lakatos
Tyrosine kinase inhibitors are widely used for treatment of certain oncohematological diseases. Several clinical studies have confirmed that specific BCR-ABL tyrosine kinase inhibitors alter the physiological process of bone tissue in a complex and unclearly identified manner. Since these treatments are being given to more and more patients, and the therapy takes decades or lasts even lifelong, it is justifiable to obtain more detailed knowledge of the molecular background of these mechanisms. In this article the authors summarize preliminary research results and human clinical observations on imatinib and nilotinib which are related to bone metabolism, and present the results of their own experiments in in vitro osteoblast cultures...
September 2016: Orvosi Hetilap
https://www.readbyqxmd.com/read/27588946/complications-of-peripherally-inserted-central-venous-catheters-a-retrospective-cohort-study
#16
Paula Parás-Bravo, María Paz-Zulueta, Raquel Sarabia-Lavin, Francisco Jose Amo-Setién, Manuel Herrero-Montes, Encarnación Olavarría-Beivíde, Mercedes Rodríguez-Rodríguez, Blanca Torres-Manrique, Carlos Rodríguez-de la Vega, Vanesa Caso-Álvarez, Laura González-Parralo, Francisco Manuel Antolín-Juárez
BACKGROUND AND AIM: The use of venous catheters is a widespread practice, especially in oncological and oncohematological units. The objective of this study was to evaluate the complications associated with peripherally inserted central catheters (PICCs) in a cohort of patients. MATERIALS AND METHODS: In this retrospective cohort study, we included all patient carrying PICCs (n = 603) inserted at our institute between October 2010 and December 2013. The main variables collected were medical diagnosis, catheter care, location, duration of catheterization, reasons for catheter removal, complications, and nursing care...
2016: PloS One
https://www.readbyqxmd.com/read/27570993/is-there-an-overprescription-of-proton-pump-inhibitors-in-oncohematologic-patients-undergoing-ambulatory-oncospecific-treatment
#17
Meritxell Pujal Herranz
OBJECTIVE: The aim of this study is to evaluate the prevalence of proton pump inhibitors (PPIs) prescription, and the level of adequacy of the indication of these drugs in oncohematologic patients under ambulatory oncoespecific treatment. METHOD: An observational descriptive study in oncohematologic patients under ambulatory oncoespecific treatment. A protocol for the rational use of PPI targeted to oncohematologic patients based on the PPI protocol of our hospital was designed...
September 1, 2016: Farmacia Hospitalaria
https://www.readbyqxmd.com/read/27409063/rehabilitative-intervention-during-and-after-pediatric-hematopoietic-stem-cell-transplantation-an-analysis-of-the-existing-literature
#18
Francesca Rossi, Monica Coppo, Giulia Zucchetti, Daniela Bazzano, Federica Ricci, Elena Vassallo, Francesca Nesi, Franca Fagioli
Hematopoietic stem cell transplantation is a therapeutic strategy for several oncohematological diseases. It increases survival rates but leads to a high incidence of related effects. The objective of this paper was to examine the existing literature on physical exercise interventions among pediatric HSCT recipients to explore the most often utilized rehabilitative assessment and treatment tools. Studies published from 2002 to April 1, 2015 were selected: 10 studies were included. A previous literary review has shown that rehabilitation programs have a positive impact on quality of life...
November 2016: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/27289777/mortality-of-oncohematologic-patients-admitted-to-the-intensive-care-unit-icu-who-required-invasive-mechanical-ventilation-imv-do-we-have-to-delay-intubation
#19
Y Corcia Palomo, T Knight Asorey, I Espigado Tocino, L Martín Villén, A Gutiérrez Pizarrayo, J Garnacho Montero
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
https://www.readbyqxmd.com/read/27275635/-introduction-to-the-molecular-diagnostic-methods-of-oncohematology
#20
Attila Péter Király, Donát Alpár, Viktória Fésüs, Dóra Marosvári, András Matolcsy, Csaba Bödör
Owing to our rapidly expanding knowledge on the genetic background of various oncohematologic diseases and the introduction of novel targeted therapies, molecular genetic techniques have been playing an increasingly important role in the diagnostics and follow-up of hematological malignancies. The various DNA- and RNA-based in situ hybridization, polymerase chain reaction and sequencing technologies are of key significance in diagnostics, classification and prognostic assessment of these diseases, as well as in the monitoring of minimal residual disease and selection of the most appropriate targeted therapy...
June 6, 2016: Magyar Onkologia
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