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María Belén Cerliani, Walter Pavicic, Juan Antonio Gili, Graciela Klein, Silvia Saba, Silvina Richard
AIM: To analyze the association between oncohematological diseases and GSTT1/GSTM1/CYP1A1 polymorphisms, dietary habits and smoking, in an argentine hospital-based case-control study. METHODS: This hospital-based case-control study involved 125 patients with oncohematological diseases and 310 control subjects. A questionnaire was used to obtain sociodemographic data and information about habits. Blood samples were collected, and DNA was extracted using salting out methods...
October 10, 2016: World Journal of Clinical Oncology
Müge Aydoğdu, Antonio M Esquinas
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
Cinthia Mendes Rodrigues, Ellen Maria Campos Pires, Jorge Patrick Oliveira Feliciano, Jose Mauro Vieira, Leandro Utino Taniguchi
No abstract text is available yet for this article.
September 2016: Revista Brasileira de Terapia Intensiva
Belén Encina, Leonel Lagunes, Marc Morales-Codina
Sepsis and septic shock remain a major cause of mortality among critically ill patient. This is particularly relevant among cancer patients as highlighted by different series showing that up to one in five patients admitted to intensive care units (ICU) with sepsis have cancer, and also, sepsis is a leading reason for ICU admission in patients with cancer. The classic predictors of mortality among these patients (such as cancer lineage, neutropenia degree, or bone marrow transplantation history) have changed during the last decades, and they should no longer be used to rule out ICU admission...
September 2016: Annals of Translational Medicine
Inès Vergnolle, Kaoutar Allou, Francis Lacombe, François Xavier Mahon, Jean-Philippe Vial
The HematoFlow™ system is used in the hematology laboratory of the University Hospital of Bordeaux since July, 2011. The HematoFlow™ solution is the combination of a sample preparator (FP1000) and a 5 color flow cytometer (FC500) linked by a middleware (Remisol™). This system is used in second line when flags are activated by the hematology instrument and/or if the sample comes from the OncoHematology Department. Improvements in hematology disease diagnosis and follow-up were possible using this system...
October 1, 2016: Annales de Biologie Clinique
Gyöngyi Kirschner, Bernadett Balla, János Kósa, Péter Horváth, Andrea Kövesdi, Gergely Lakatos, István Takács, Zsolt Nagy, Bálint Tóbiás, Kristóf Árvai, Péter Lakatos
Tyrosine kinase inhibitors are widely used for treatment of certain oncohematological diseases. Several clinical studies have confirmed that specific BCR-ABL tyrosine kinase inhibitors alter the physiological process of bone tissue in a complex and unclearly identified manner. Since these treatments are being given to more and more patients, and the therapy takes decades or lasts even lifelong, it is justifiable to obtain more detailed knowledge of the molecular background of these mechanisms. In this article the authors summarize preliminary research results and human clinical observations on imatinib and nilotinib which are related to bone metabolism, and present the results of their own experiments in in vitro osteoblast cultures...
September 2016: Orvosi Hetilap
Paula Parás-Bravo, María Paz-Zulueta, Raquel Sarabia-Lavin, Francisco Jose Amo-Setién, Manuel Herrero-Montes, Encarnación Olavarría-Beivíde, Mercedes Rodríguez-Rodríguez, Blanca Torres-Manrique, Carlos Rodríguez-de la Vega, Vanesa Caso-Álvarez, Laura González-Parralo, Francisco Manuel Antolín-Juárez
BACKGROUND AND AIM: The use of venous catheters is a widespread practice, especially in oncological and oncohematological units. The objective of this study was to evaluate the complications associated with peripherally inserted central catheters (PICCs) in a cohort of patients. MATERIALS AND METHODS: In this retrospective cohort study, we included all patient carrying PICCs (n = 603) inserted at our institute between October 2010 and December 2013. The main variables collected were medical diagnosis, catheter care, location, duration of catheterization, reasons for catheter removal, complications, and nursing care...
2016: PloS One
Meritxell Pujal Herranz
OBJECTIVE: The aim of this study is to evaluate the prevalence of proton pump inhibitors (PPIs) prescription, and the level of adequacy of the indication of these drugs in oncohematologic patients under ambulatory oncoespecific treatment. METHOD: An observational descriptive study in oncohematologic patients under ambulatory oncoespecific treatment. A protocol for the rational use of PPI targeted to oncohematologic patients based on the PPI protocol of our hospital was designed...
September 2016: Farmacia Hospitalaria
Francesca Rossi, Monica Coppo, Giulia Zucchetti, Daniela Bazzano, Federica Ricci, Elena Vassallo, Francesca Nesi, Franca Fagioli
Hematopoietic stem cell transplantation is a therapeutic strategy for several oncohematological diseases. It increases survival rates but leads to a high incidence of related effects. The objective of this paper was to examine the existing literature on physical exercise interventions among pediatric HSCT recipients to explore the most often utilized rehabilitative assessment and treatment tools. Studies published from 2002 to April 1, 2015 were selected: 10 studies were included. A previous literary review has shown that rehabilitation programs have a positive impact on quality of life...
November 2016: Pediatric Blood & Cancer
Y Corcia Palomo, T Knight Asorey, I Espigado Tocino, L Martín Villén, A Gutiérrez Pizarrayo, J Garnacho Montero
No abstract text is available yet for this article.
December 2015: Intensive Care Medicine Experimental
Attila Péter Király, Donát Alpár, Viktória Fésüs, Dóra Marosvári, András Matolcsy, Csaba Bödör
Owing to our rapidly expanding knowledge on the genetic background of various oncohematologic diseases and the introduction of novel targeted therapies, molecular genetic techniques have been playing an increasingly important role in the diagnostics and follow-up of hematological malignancies. The various DNA- and RNA-based in situ hybridization, polymerase chain reaction and sequencing technologies are of key significance in diagnostics, classification and prognostic assessment of these diseases, as well as in the monitoring of minimal residual disease and selection of the most appropriate targeted therapy...
June 6, 2016: Magyar Onkologia
Cinthia Mendes Rodrigues, Ellen Maria Campos Pires, Jorge Patrick Oliveira Feliciano, Jose Mauro Vieira, Leandro Utino Taniguchi
OBJECTIVE: The purpose of our study was to determine the admission factors associated with intensive care unit readmission among oncohematological patients. METHODS: Retrospective cohort study using an intensive care unit database from a tertiary oncological center. The participants included 1,872 critically ill oncohematological patients who were admitted to the intensive care unit from January 2012 to December 2014 and who were subsequently discharged alive. We used univariate and multivariate analysis to identify the admission risk factors associated with later intensive care unit readmission...
January 2016: Revista Brasileira de Terapia Intensiva
C Sagnelli, M Macera, M Pisaturo, R Zampino, M Coppola, E Sagnelli
INTRODUCTION: Occult hepatitis B infection (OBI), a virological condition characterized by a low release of Hepatitis B Virus (HBV) from liver cells and low HBV-DNA levels in serum and/or liver tissue of HBsAg-negative subjects, may reactivate in oncohematological patients undergoing immunosuppression by aggressive chemotherapy or hematopoietic stem cell transplantation. The entity of OBI reactivation varies from an increase in HBV replication without liver damage to an active HBV replication followed by liver cell necrosis, frequently severe and in some cases life threatening...
October 2016: Infection
Gregorio A Brunetti, Giovanna Palumbo, Giacomo S Morano, Erminia Baldacci, Ida Carmosino, Giorgia Annechini, Romina Talone, Sara Kiflom, Giada Mastrogiacomo, Sara Grammatico, Marta Chisini, Adriana Costa, Andrea Tendas, Laura Scaramucci, Marco Giovannini, Pasquale Niscola, Maria T Petrucci, Claudio Cartoni
BACKGROUND: More than 50% of oncohematological patients suffer from pain syndrome, mostly originating from the bone, which often include nociceptive and neuropathic complaints. Tapentadol, a recently available treatment option for cancer pain, exerts a dual analgesic mechanisms (opioid and noradrenergic), allowing for a high clinical efficacy as well as for a reduction in adverse events compared to traditional opioids. AIM: To explore the safety and efficacy of tapentadol as a suitable agent for the pain management in the setting of oncohematology...
2016: Cardiovascular & Hematological Agents in Medicinal Chemistry
Alessandra Iurlo, Daniele Cattaneo, Nicola Orofino, Cristina Bucelli, Sonia Fabris, Agostino Cortelezzi
BACKGROUND: Anagrelide is an orally active, quinazolone-derived, platelet-lowering agent that acts by blocking megakaryocyte maturation and polyploidization as well as proplatelet formation, and is currently indicated for second-line treatment of high-risk patients with essential thrombocythemia (ET) in Europe. In recent years various clinical trials have confirmed the safety and efficacy of this drug in ET, with some also considering Janus kinase 2 (JAK2) mutational status, but have not confirmed the impact that the other driver mutations, i...
June 2016: BioDrugs: Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Chiara Magni, Francesca Maggioni, Angelo Ricci, Elena Barisone, Momcilo Jankovic, Emma Sarlo Postiglione, Enrica Cargnel, Barbara Rita Barricelli, Stefano Valtolina, Laura Veneroni, Stefano Chiaravalli, Pietro Lapidari, Mirko Capelletti, Carlo A Clerici, Andrea Biondi, Andrea Ferrari
INTRODUCTION: Adolescents with cancer often experience a longer diagnostic delay than children, mainly because they take longer to go to a doctor. The Italian Society for Adolescents with Oncohematological Diseases (SIAMO) has launched an information campaign focusing on raising adolescents' awareness of the importance of diagnosing cancer early. METHODS: The concepts of the campaign were developed by a scientific committee of clinicians, cancer patients and their parents, and marketing experts...
March 26, 2016: Tumori
Marta Tremolada, Sabrina Bonichini, Giuseppe Basso, Marta Pillon
With modern therapies and supportive care, survival rates of childhood cancer have increased considerably. However, there are long-term psychological sequelae of these treatments that may not manifest until pediatric survivors are into adulthood. The prevalence of post-traumatic stress disorder in young adult survivors of childhood cancer ranges from 6.2 to 22%; associated risk factors are young age at the assessment, female gender, low education level, and some disease-related factors. The aim of this study was to investigate, in adolescent and young adult (AYA) survivors of childhood cancer, the incidence and severity of post-traumatic stress symptoms (PTSSs), and to identify the risk factors and the associated post-traumatic growth (PTG) index...
2016: Frontiers in Psychology
Romeo Gabriel Mihaila
BACKGROUND: Na(+)/H(+) exchanger-1 (NHE-1) is involved in pH regulation and is up-regulated in different malignancies. Activation of NHE-1 is one way for allowing cells to avoid intracellular acidification and protect them against apoptosis. Inhibitors of NHE-1 are able to decrease intracellular pH and induce apoptosis. Some statins can also act by partial inhibition of NHE-1. This review presents progress in understanding the mechanisms of action of these inhibitors, connections with certain genetic mutations and acquired treatment resistance, as well as new patents on them...
December 2015: Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia
Y Corcía Palomo, T Knight Asorey, I Espigado, L Martín Villén, J Garnacho Montero
BACKGROUND: Both autologous and allogenic hematopoietic stem cell transplantation (HSCT) are potentially curative treatments for hematological malignancies. Patients with related complications may need admission to the intensive care unit (ICU) for specific therapy and organ support. A consensus on treatment between hematologists and intensive care specialists is essential. METHODS: This observasional, retrospective study included all recipients of HSCT in a third-level hospital during 2013 and 2014...
November 2015: Transplantation Proceedings
Cíntia Ferreira Gonçalves, Mariana Vargas Lindemaier E Silva, Luciane Rezende Costa, Orlando Ayrton de Toledo
BACKGROUND: The oral condition in children undergoing oncohematological treatment can have a negative impact on the course of disease. Little is known about survival of tooth restorations in these patients. The aim of this study was to evaluate the longevity of restorations and sealants performed by Atraumatic Restoration Treatment (ART) in patients undergoing oncohematological treatment. METHODS: ART single surface restorations and sealants were performed in the experimental group (E), which comprised children (2-13 years old) undergoing oncohematological treatment, and in the control group (C), in which patients did not undergo such treatment...
2015: BMC Oral Health
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