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Nucleosome assembly protein 1-like 1

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https://www.readbyqxmd.com/read/28687276/nap1l1-regulates-nf-%C3%AE%C2%BAb-signaling-pathway-acting-on-anti-apoptotic-mcl-1-gene-expression
#1
Toshiaki Tanaka, Yasukazu Hozumi, Mitsuyoshi Iino, Kaoru Goto
Nuclear factor-κB (NF-κB) participates in apoptosis signaling pathway under various pathophysiological conditions. It exerts transcriptional control on the anti-apoptotic Bcl-2 family, such as Bcl-2, Bcl-xl, and Mcl-1, which act on the mitochondrial outer membrane. Previously, we described that NF-κB is negatively regulated by diacylglycerol kinase ζ (DGKζ), an enzyme that phosphorylates a lipid second messenger diacylglycerol. DGKζ downregulation enhances inhibitors of NF-κB α (IκBα) degradation and p65 subunit phosphorylation, leading to enhanced NF-κB transcriptional activity...
July 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28659470/hepatitis-c-virus-ns5a-targets-nucleosome-assembly-protein-nap1l1-to-control-the-innate-cellular-response
#2
Recep Emrah Çevik, Mia Cesarec, Ana Da Silva Filipe, Danilo Licastro, John McLauchlan, Alessandro Marcello
Hepatitis C virus (HCV) is a single-stranded positive-sense RNA hepatotropic virus. Despite cellular defenses, HCV is able to replicate in hepatocytes and to establish a chronic infection that could lead to severe complications and hepatocellular carcinoma. An important player in subverting the host response to HCV infection is the viral nonstructural protein NS5A, which, in addition to its role in replication and assembly, targets several pathways involved in the cellular response to viral infection. Several unbiased screens identified nucleosome assembly protein 1-like 1 (NAP1L1) as an interaction partner of HCV NS5A...
September 15, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28615203/phosphorylation-of-serine-225-in-hepatitis-c-virus-ns5a-regulates-protein-protein-interactions
#3
Niluka Goonawardane, Anna Gebhardt, Christopher Bartlett, Andreas Pichlmair, Mark Harris
Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a phosphoprotein that plays key, yet poorly defined, roles in both virus genome replication and virion assembly/release. It has been proposed that differential phosphorylation could act as a switch to regulate the various functions of NS5A; however, the mechanistic details of the role of this posttranslational modification in the virus life cycle remain obscure. We previously reported (D. Ross-Thriepland, J. Mankouri, and M. Harris, J Virol 89:3123-3135, 2015, doi:10...
September 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28526651/disruption-of-nnat-nap1l5-and-mkrn3-dna-methylation-and-transcription-in-rabbit-parthenogenetic-fetuses
#4
Dongxu Wang, Zhiquan Liu, Haobin Yao, Yang Hao, Lina Zhou, Jian Du, Yixin Zhu, Yuxin Xu, Guodong Wang, Yuning Song, Zhanjun Li
Parthenogenetically activated oocytes cannot develop to term in mammals due to lack of paternal gene expression. Disruption of imprinted gene expression and DNA methylation status in parthenogenetic fetuses has been reported in mice and pigs, but not in rabbits. In this study, the genomic imprinting status of the paternally expressed genes Neuronatin (NNAT), Nucleosome assembly protein 1-like 5 (NAP1L5), and Makorin ring finger protein 3 (MKRN3) was compared between rabbit parthenogenetic (PA) and normally fertilized fetuses (Con) using quantitative real-time PCR (qRT-PCR) and bisulfite sequencing PCR (BSP)...
August 30, 2017: Gene
https://www.readbyqxmd.com/read/28235398/testis-specific-y-like-5-gene-expression-methylation-and-implications-for-drug-sensitivity-in-prostate-carcinoma
#5
Senthil R Kumar, Jeffrey N Bryan, Magda Esebua, James Amos-Landgraf, Tanner J May
BACKGROUND: TSPYL5, a putative tumor suppressor gene, belongs to the nucleosome assembly protein family. The chromosomal location of the TSPYL5 gene is 8Q22.1, and its exact role in prostate cancer etiology remains unclear. Further TSPYL5 gene and protein expression in prostate carcinoma cells and diseased tissues including its susceptibility for epigenetic silencing is unknown. Also, not known is the variation in TSPYL5 protein expression with regards to progression of prostatic carcinoma and its possible role in drug sensitivity...
February 24, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28123501/identification-of-the-molecular-mechanisms-underlying-dilated-cardiomyopathy-via-bioinformatic-analysis-of-gene-expression-profiles
#6
Hu Zhang, Zhuo Yu, Jianchao He, Baotong Hua, Guiming Zhang
In the present study, gene expression profiles of patients with dilated cardiomyopathy (DCM) were re-analyzed with bioinformatics tools to investigate the molecular mechanisms underlying DCM. Gene expression dataset GSE3585 was downloaded from Gene Expression Omnibus, which included seven heart biopsy samples obtained from patients with DCM and five healthy controls. Differential analysis was performed using a Limma package in R to screen for differentially expressed genes (DEGs). Functional enrichment analysis was subsequently conducted for DEGs using the Database for Annotation, Visualization and Integration Discovery...
January 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27974641/proper-cytoskeletal-architecture-beneath-the-plasma-membrane-of-red-blood-cells-requires-ttll4
#7
Faryal Ijaz, Yasue Hatanaka, Takahiro Hatanaka, Koji Tsutsumi, Takayuki Iwaki, Kazuo Umemura, Koji Ikegami, Mitsutoshi Setou
Mammalian red blood cells (RBCs) circulate through blood vessels, including capillaries, for tens of days under high mechanical stress. RBCs tolerate this mechanical stress while maintaining their shape because of their elastic membrane skeleton. This membrane skeleton consists of spectrin-actin lattices arranged as quasi-hexagonal units beneath the plasma membrane. In this study, we found that the organization of the RBC cytoskeleton requires tubulin tyrosine ligase-like 4 (Ttll4). RBCs from Ttll4-knockout mice showed larger average diameters in smear test...
February 15, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/27599637/kshv-encoded-lana-recruits-nucleosome-assembly-protein-nap1l1-for-regulating-viral-dna-replication-and-transcription
#8
Namrata Gupta, Suhani Thakker, Subhash C Verma
The establishment of latency is an essential for lifelong persistence and pathogenesis of Kaposi's sarcoma-associated herpesvirus (KSHV). Latency-associated nuclear antigen (LANA) is the most abundantly expressed protein during latency and is important for viral genome replication and transcription. Replication-coupled nucleosome assembly is a major step in packaging the newly synthesized DNA into chromatin, but the mechanism of KSHV genome chromatinization post-replication is not understood. Here, we show that nucleosome assembly protein 1-like protein 1 (NAP1L1) associates with LANA...
September 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27591891/the-chromatin-remodelling-protein-chd1-contains-a-previously-unrecognised-c-terminal-helical-domain
#9
Biswaranjan Mohanty, Stephanie Helder, Ana P G Silva, Joel P Mackay, Daniel P Ryan
The packaging of eukaryotic DNA into nucleosomes, and the organisation of these nucleosomes into chromatin, plays a critical role in regulating all DNA-associated processes. Chromodomain helicase DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin remodelling protein that is conserved throughout eukaryotes and has an ability to assemble and organise nucleosomes both in vitro and in vivo. This activity is involved in the regulation of transcription and is implicated in mammalian development and stem cell biology...
October 23, 2016: Journal of Molecular Biology
https://www.readbyqxmd.com/read/27091003/conservation-of-imprinting-of-mkrn3-and-nap1l5-in-rabbits
#10
L Yuan, L Lai, F Duan, M Chen, J Deng, Z Li
Maternally imprinted genes of makorin ring finger protein 3 (MKRN3) and nucleosome assembly protein 1-like 5 (NAP1L5) have been identified in many species but have not yet been investigated in rabbits. In this study, a polymorphism-based approach and bisulfite-sequencing PCR (BSP) were used to determine the imprinting status of MKRN3 and NAP1L5 in rabbits. The single nucleotide polymorphism (SNP)-based sequencing results demonstrated that MKRN3 and NAP1L5 were expressed preferentially from the paternal allele...
August 2016: Animal Genetics
https://www.readbyqxmd.com/read/27074396/effect-of-the-spiroiminodihydantoin-lesion-on-nucleosome-stability-and-positioning
#11
Erika M Norabuena, Sara Barnes Williams, Margaret A Klureza, Liana J Goehring, Brian Gruessner, Mala L Radhakrishnan, Elizabeth R Jamieson, Megan E Núñez
DNA is constantly under attack by oxidants, generating a variety of potentially mutagenic covalently modified species, including oxidized guanine base products. One such product is spiroiminodihydantoin (Sp), a chiral, propeller-shaped lesion that strongly destabilizes the DNA helix in its vicinity. Despite its unusual shape and thermodynamic effect on double-stranded DNA structure, DNA duplexes containing the Sp lesion form stable nucleosomes upon being incubated with histone octamers. Indeed, among six different combinations of lesion location and stereochemistry, only two duplexes display a diminished ability to form nucleosomes, and these only by ∼25%; the other four are statistically indistinguishable from the control...
April 26, 2016: Biochemistry
https://www.readbyqxmd.com/read/26967585/identification-of-candidate-genes-in-atopic-dermatitis-based-on-bioinformatic-methods
#12
Yingguo Ding, Xia Shao, Xiaomin Li, You Zhai, Yu Zhang, Su Wang, Hong Fang
BACKGROUND: Atopic dermatitis (AD) is a chronic or relapsing inflammatory disorder of the skin that frequently precedes asthma and allergic disorders. This study aimed to identify candidate genes related to AD using bioinformatic methods. METHODS: The microarray data of GSE32924, including 12 nonlesional AD (ANL) and 13 lesional AD (AL) skin samples obtained from 14 patients with AD as well as eight other normal human skin samples, was downloaded from the Gene Expression Omnibus database...
July 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/26929406/loss-of-interdependent-binding-by-the-foxo1-and-foxa1-a2-forkhead-transcription-factors-culminates-in-perturbation-of-active-chromatin-marks-and-binding-of-transcriptional-regulators-at-insulin-sensitive-genes
#13
Akua Yalley, Daniel Schill, Mitsutoki Hatta, Nicole Johnson, Lisa Ann Cirillo
FoxO1 binds to insulin response elements located in the promoters of insulin-like growth factor-binding protein 1 (IGFBP1) and glucose-6-phosphatase (G6Pase), activating their expression. Insulin-mediated phosphorylation of FoxO1 promotes cytoplasmic translocation, inhibiting FoxO1-mediated transactivation. We have previously demonstrated that FoxO1 opens and remodels chromatin assembled from the IGFBP1 promoter via a highly conserved winged helix motif. This finding, which established FoxO1 as a "pioneer" factor, suggested a model whereby FoxO1 chromatin remodeling at regulatory targets facilitates binding and recruitment of additional regulatory factors...
April 15, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26916160/dichotomous-life-of-dna-binding-high-mobility-group-box1-protein-in-human-health-and-disease
#14
REVIEW
Neelam Lohani, Moganty R Rajeswari
The High mobility group box 1 (HMGB1) protein is an extremely versatile, highly conserved nuclear protein, with its unique intracellular and extracellular functions mediated by its relatively simple domain structure. Within the nucleus, HMGB1 binds to DNA minor groove in a nonspecific manner and causes bends in the double helix thus helps in recruiting a number of DNA binding protein and transcription factors, to facilitate transcription of various genes. HMGB1 also helps in DNA repair, chromatin remodeling, V (D) J recombination, and assembly of nucleosome on the chromatin...
2016: Current Protein & Peptide Science
https://www.readbyqxmd.com/read/26884462/histone-chaperone-nap1-is-a-major-regulator-of-histone-h2a-h2b-dynamics-at-the-inducible-gal-locus
#15
Xu Chen, Sheena D'Arcy, Catherine A Radebaugh, Daniel D Krzizike, Holli A Giebler, Liangquan Huang, Jennifer K Nyborg, Karolin Luger, Laurie A Stargell
Histone chaperones, like nucleosome assembly protein 1 (Nap1), play a critical role in the maintenance of chromatin architecture. Here, we use the GAL locus in Saccharomyces cerevisiae to investigate the influence of Nap1 on chromatin structure and histone dynamics during distinct transcriptional states. When the GAL locus is not expressed, cells lacking Nap1 show an accumulation of histone H2A-H2B but not histone H3-H4 at this locus. Excess H2A-H2B interacts with the linker DNA between nucleosomes, and the interaction is independent of the inherent DNA-binding affinity of H2A-H2B for these particular sequences as measured in vitro When the GAL locus is transcribed, excess H2A-H2B is reversed, and levels of all chromatin-bound histones are depleted in cells lacking Nap1...
April 2016: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/26824453/nucleosome-assembly-protein-1-like-1-nap1l1-regulates-the-proliferation-of-murine-induced-pluripotent-stem-cells
#16
Yuan Yan, Peipei Yin, Hui Gong, Yuanyuan Xue, Guoping Zhang, Bo Fang, Zhidan Chen, Yang Li, Chunjie Yang, Zheyong Huang, Xiangdong Yang, Junbo Ge, Yunzeng Zou
BACKGROUND/AIMS: To investigate whether nucleosome assembly protein 1-like 1 (Nap1l1) regulates the proliferation of induced pluripotent stem cells (iPSC) and the potential mechanisms. METHODS: Nap1l1-knockdown-iPSC and Nap1l1-overexpression-iPSC were constructed by transfection of lentiviral particles. The proliferation of iPSC was detected by MTT analysis, and cell cycle was analyzed by flow cytometry. RESULTS: Nap1l1 overexpression promoted iPSC proliferation and induced G2/M transition compared to their control iPSC while Nap1l1-knockdown-iPSC dramatically displayed the reduced proliferation and accumulated G2/M phase cells...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/26378228/identification-of-the-iswi-chromatin-remodeling-complex-of-the-early-branching-eukaryote-trypanosoma-brucei
#17
Tara M Stanne, Mani Shankar Narayanan, Sophie Ridewood, Alexandra Ling, Kathrin Witmer, Manish Kushwaha, Simone Wiesler, Bill Wickstead, Jennifer Wood, Gloria Rudenko
ISWI chromatin remodelers are highly conserved in eukaryotes and are important for the assembly and spacing of nucleosomes, thereby controlling transcription initiation and elongation. ISWI is typically associated with different subunits, forming specialized complexes with discrete functions. In the unicellular parasite Trypanosoma brucei, which causes African sleeping sickness, TbISWI down-regulates RNA polymerase I (Pol I)-transcribed variant surface glycoprotein (VSG) gene expression sites (ESs), which are monoallelically expressed...
November 6, 2015: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/26066981/the-role-of-the-chromatin-assembly-complex-caf-1-and-its-p60-subunit-chaf1b-in-homeostasis-and-disease
#18
REVIEW
Andrew Volk, John D Crispino
Nucleosome assembly following DNA synthesis is critical for maintaining genomic stability. The proteins directly responsible for shuttling newly synthesized histones H3 and H4 from the cytoplasm to the assembly fork during DNA replication comprise the Chromatin Assembly Factor 1 complex (CAF-1). Whereas the diverse functions of the large (CAF-1-p150, CHAF1a) and small (RbAp48, p48) subunits of the CAF-1 complex have been well-characterized in many tissues and extend beyond histone chaperone activity, the contributions of the medium subunit (CAF-1-p60, CHAF1b) are much less well understood...
August 2015: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/25374266/clinical-implications-of-mta-proteins-in-human-cancer
#19
REVIEW
Ekjot Kaur, Sudeep Gupta, Shilpee Dutt
Metastasis-associated gene or metastasis tumor antigen 1 (MTA1) is a new member of cancer progression-related gene family. It was first identified in rat mammary adenocarcinoma and later recognized as an important constituent of nucleosomal remodeling complex (NuRD), displaying dual regulatory functions as a co-repressor and co-activator for a large number of genes. Chromatin remodelers are ATP-dependent multi-protein chromatin modifying machines. These complexes alter the nucleosome positioning regulating the accessibility of genomic DNA to various transcription factors and thus modulate eukaryotic gene transcription...
December 2014: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/25164756/comparative-analysis-of-metazoan-chromatin-organization
#20
COMPARATIVE STUDY
Joshua W K Ho, Youngsook L Jung, Tao Liu, Burak H Alver, Soohyun Lee, Kohta Ikegami, Kyung-Ah Sohn, Aki Minoda, Michael Y Tolstorukov, Alex Appert, Stephen C J Parker, Tingting Gu, Anshul Kundaje, Nicole C Riddle, Eric Bishop, Thea A Egelhofer, Sheng'en Shawn Hu, Artyom A Alekseyenko, Andreas Rechtsteiner, Dalal Asker, Jason A Belsky, Sarah K Bowman, Q Brent Chen, Ron A-J Chen, Daniel S Day, Yan Dong, Andrea C Dose, Xikun Duan, Charles B Epstein, Sevinc Ercan, Elise A Feingold, Francesco Ferrari, Jacob M Garrigues, Nils Gehlenborg, Peter J Good, Psalm Haseley, Daniel He, Moritz Herrmann, Michael M Hoffman, Tess E Jeffers, Peter V Kharchenko, Paulina Kolasinska-Zwierz, Chitra V Kotwaliwale, Nischay Kumar, Sasha A Langley, Erica N Larschan, Isabel Latorre, Maxwell W Libbrecht, Xueqiu Lin, Richard Park, Michael J Pazin, Hoang N Pham, Annette Plachetka, Bo Qin, Yuri B Schwartz, Noam Shoresh, Przemyslaw Stempor, Anne Vielle, Chengyang Wang, Christina M Whittle, Huiling Xue, Robert E Kingston, Ju Han Kim, Bradley E Bernstein, Abby F Dernburg, Vincenzo Pirrotta, Mitzi I Kuroda, William S Noble, Thomas D Tullius, Manolis Kellis, David M MacAlpine, Susan Strome, Sarah C R Elgin, Xiaole Shirley Liu, Jason D Lieb, Julie Ahringer, Gary H Karpen, Peter J Park
Genome function is dynamically regulated in part by chromatin, which consists of the histones, non-histone proteins and RNA molecules that package DNA. Studies in Caenorhabditis elegans and Drosophila melanogaster have contributed substantially to our understanding of molecular mechanisms of genome function in humans, and have revealed conservation of chromatin components and mechanisms. Nevertheless, the three organisms have markedly different genome sizes, chromosome architecture and gene organization. On human and fly chromosomes, for example, pericentric heterochromatin flanks single centromeres, whereas worm chromosomes have dispersed heterochromatin-like regions enriched in the distal chromosomal 'arms', and centromeres distributed along their lengths...
August 28, 2014: Nature
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