Qiwen Dong, Huaiying Lin, Marie-Maude Allen, Julian R Garneau, Jonathan K Sia, Rita C Smith, Fidel Haro, Tracy McMillen, Rosemary L Pope, Carolyn Metcalfe, Victoria Burgo, Che Woodson, Nicholas Dylla, Claire Kohout, Anitha Sundararajan, Evan S Snitkin, Vincent B Young, Louis-Charles Fortier, Mini Kamboj, Eric G Pamer
Clostridioides difficile (C. difficile) , a leading cause of nosocomial infection, produces toxins that damage the colonic epithelium and results in colitis that varies from mild to fulminant. Variation in disease severity is poorly understood and has been attributed to host factors (age, immune competence and intestinal microbiome composition) and/or virulence differences between C. difficile strains, with some, such as the epidemic BI/NAP1/027 (MLST1) strain, being associated with greater virulence. We tested 23 MLST1(ST1) C...
January 12, 2023: bioRxiv