Francisco Dominguez, Nikita Shiliaev, Tetyana Lukash, Peter Agback, Oksana Palchevska, Joseph R Gould, Chetan D Meshram, Peter E Prevelige, Todd J Green, Tatiana Agback, Elena I Frolova, Ilya Frolov
Chikungunya virus (CHIKV) is one of the most pathogenic members of the Alphavirus genus in the Togaviridae family. Within the last two decades, CHIKV has expanded its presence to both hemispheres and is currently circulating in both Old and New Worlds. Despite the severity and persistence of the arthritis it causes in humans, no approved vaccines or therapeutic means have been developed for CHIKV infection. Replication of alphaviruses, including CHIKV, is determined not only by their nonstructural proteins, but also by a wide range of host factors, which are indispensable components of viral replication complexes (vRCs)...
June 2, 2021: Journal of Virology