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B F Boeve, M H Silber, T J Ferman, S C Lin, E E Benarroch, A M Schmeichel, J E Ahlskog, R J Caselli, S Jacobson, M Sabbagh, C Adler, B Woodruff, T G Beach, A Iranzo, E Gelpi, J Santamaria, E Tolosa, C Singer, D C Mash, C Luca, I Arnulf, C Duyckaerts, C H Schenck, M W Mahowald, Y Dauvilliers, N R Graff-Radford, Z K Wszolek, J E Parisi, B Dugger, M E Murray, D W Dickson
OBJECTIVE: To determine the pathologic substrates in patients with rapid eye movement (REM) sleep behavior disorder (RBD) with or without a coexisting neurologic disorder. METHODS: The clinical and neuropathologic findings were analyzed on all autopsied cases from one of the collaborating sites in North America and Europe, were evaluated from January 1990 to March 2012, and were diagnosed with polysomnogram (PSG)-proven or probable RBD with or without a coexisting neurologic disorder...
August 2013: Sleep Medicine
Takamichi Muraki, Masami Taki, Yoshie Hasegawa, Hiroaki Iwaki, Peter C K Lau
The 2-nitrobenzoic acid degradation pathway of Pseudomonas fluorescens strain KU-7 proceeds via a novel 3-hydroxyanthranilate intermediate. In this study, we cloned and sequenced a 19-kb DNA locus of strain KU-7 that encompasses the 3-hydroxyanthranilate meta-cleavage pathway genes. The gene cluster, designated nbaEXHJIGFCDR, is organized tightly and in the same direction. The nbaC and nbaD gene products were found to be novel homologs of the eukaryotic 3-hydroxyanthranilate 3,4-dioxygenase and 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase, respectively...
March 2003: Applied and Environmental Microbiology
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