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High resolution anoscopy

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https://www.readbyqxmd.com/read/29771801/detection-rate-of-high-grade-squamous-intraepithelial-lesions-as-a-quality-assurance-metric-for-high-resolution-anoscopy-in-hiv-positive-men
#1
Matthijs L Siegenbeek van Heukelom, Elske Marra, Irina Cairo, Arne Van Eeden, Maarten F Schim van der Loeff, Henry J C De Vries, Jan M Prins
BACKGROUND: High-resolution anoscopy-guided biopsies are the gold standard for identifying anal intraepithelial neoplasia, but diagnosing high-grade squamous intraepithelial lesions depends on the skills of the anoscopist. OBJECTIVE: This study aims to validate the high-grade squamous intraepithelial lesion detection rate as a quality assurance metric for high-resolution anoscopy in HIV-positive men. DESIGN: This is a retrospective study. SETTING: This study was conducted at 3 HIV outpatient clinics in Amsterdam, The Netherlands...
May 15, 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29747610/the-acceptability-of-high-resolution-anoscopy-examination-in-patients-attending-a-tertiary-referral-centre
#2
Anke De-Masi, Esther Davis, Tamzin Cuming, Noreen Chindawi, Francesca Pesola, Carmelina Cappello, Susan Chambers, Julie Bowring, Adam N Rosenthal, Peter Sasieni, Mayura Nathan
BACKGROUND: High resolution anoscopy (HRA) examination is regarded as the best method for the management of anal high grade squamous intraepithelial lesions to prevent anal squamous carcinoma. However, little is known about the acceptability of this procedure. This analysis looks at patient experience of HRA examination and ablative treatment under local anaesthetic. METHODS: Patients took part in anonymised feedback of their experience immediately after their HRA examinations and/or treatments...
May 11, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29659752/performance-of-anal-cytology-compared-with-high-resolution-anoscopy-and-histology-in-women-with-lower-anogenital-tract-neoplasia
#3
Andreia Albuquerque, Michael Sheaff, Oliver Stirrup, Carmelina Cappello, Julie Bowring, Tamzin Cuming, Anke de Masi, Adam N Rosenthal, Mayura Nathan
Background: Information on the performance of anal cytology in women who are high-risk for human papillomavirus-related lesions and the factors that might influence it are largely lacking. Aims: Evaluate the performance of anal cytology in women with lower anogenital tract neoplasia. Methods: retrospective study including all new referrals of women with a previous history of anogenital neoplasia, from January 2012 to July 2017, with concomitant anal cytology and high-resolution anoscopy with or without biopsies...
April 5, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29652190/anal-cytology-institutional-statistics-correlation-with-histology-and-development-of-multidisciplinary-screening-program-with-review-of-the-current-literature
#4
Elizabeth G Morency, Tracey Harbert, Nazneen Fatima, Julia Samolcyzk, Kruti P Maniar, Ritu Nayar
CONTEXT: - The incidence of anal cancer in the United States is on the rise in high-risk populations. The anal Papanicolaou test (APT) is advocated as a screening tool, in addition to digital rectal examination and high-resolution anoscopy. OBJECTIVE: - To review our experience and the current literature to create, in cooperation with clinicians, a standardized screening and treatment algorithm given our large volume of APTs. DATA SOURCES: - All APTs collected between January 2013 and June 2015 were reviewed and correlated with follow-up/concurrent biopsy diagnoses, and clinical and social history...
April 13, 2018: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29607650/factors-associated-with-high-grade-anal-intraepithelial-lesion-in-hiv-positive-men-in-a-southern-u-s-city
#5
Melanie Ann Frank, Cecile Lahiri, Minh Ly Nguyen, C Christina Mehta, Marina Mosunjac, Lisa Flowers
The incidence of anal cancer is increased in HIV-infected patients compared to the general population. Risk factors associated with the anal cancer precursor, high-grade squamous intraepithelial lesion (HSIL), have not been extensively studied in an urban black population with late stage HIV disease. We performed a retrospective chart review of HIV infected men at the Grady Ponce de Leon Center HIV Clinic in Atlanta, Georgia referred for high resolution anoscopy (HRA), a procedure where anal tissue is examined under magnification and abnormal areas are biopsied...
April 1, 2018: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/29547439/high-grade-anal-intraepithelial-neoplasia-is-associated-with-hiv-1-rna-rectal-shedding-in-virologically-suppressed-msm
#6
Elena García-Payá, Marta Fernández, Sergio Padilla, José A García, Catalina Robledano, Victoria Ortiz de la Tabla, Félix Gutiérrez, Mar Masiá
OBJECTIVE: The protective effect of ART has not yet been definitively established in MSM. We aimed to characterize the factors associated with persistent HIV-1 RNA rectal shedding. METHODS: Prospective study including virologically suppressed MSM from an HIV cohort. High-resolution anoscopy (HRA) was performed for screening of anal dysplasia, and rectal sampling for HIV-1 RNA quantification and sexually transmitted infections (STIs) investigation through multiplex PCR...
May 15, 2018: AIDS
https://www.readbyqxmd.com/read/29528986/high-baseline-anal-human-papillomavirus-and-abnormal-anal-cytology-in-a-phase-3-trial-of-the-quadrivalent-human-papillomavirus-vaccine-in-human-immunodeficiency-virus-infected-individuals-older-than-26-years-actg-5298
#7
Ross D Cranston, Michelle S Cespedes, Pawel Paczuski, Ming Yang, Robert W Coombs, Joan Dragavon, Alfred Saah, Catherine Godfrey, Jennifer Y Webster-Cyriaque, Elizabeth Y Chiao, Barbara Bastow, Timothy Wilkin
BACKGROUND: The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women aged 9 to 26 years to prevent HPV associated anogenital high-grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in human immunodeficiency virus (HIV)-infected men who have sex with men, and women of qHPV to prevent persistent anal HPV infection. Baseline data are presented here. METHODS: Human immunodeficiency virus-infected men who have sex with men, and women 27 years or older without previous anogenital or oral cancer were enrolled...
April 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29465697/high-baseline-anal-hpv-and-abnormal-anal-cytology-in-a-phase-3-trial-of-the-quadrivalent-hpv-vaccine-in-hiv-infected-individuals-over-26-years-old-actg-5298
#8
Ross D Cranston, Michelle S Cespedes, Pawel Paczuski, Ming Yang, Robert W Coombs, Joan Dragavon, Alfred Saah, Catherine Godfrey, Jennifer Y Webster-Cyriaque, Elizabeth Y Chiao, Barbara Bastow, Timothy Wilkin
BACKGROUND: The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women 9-26 years to prevent HPV associated anogenital high grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in HIV-infected men who have sex with men (MSM), and women of qHPV to prevent persistent anal HPV infection. Baseline data is presented here. METHODS: HIV-infected MSM, and women ≥ 27 years without previous anogenital or oral cancer were enrolled...
October 13, 2017: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29431149/antiretroviral-therapy-suppresses-rectal-hiv-rna-shedding-despite-inflammation-in-msm-with-rectal-c-trachomatis-and-n-gonorrhoeae-infections-a-cross-sectional-single-center-study
#9
Julian Storim, Jens Verheyen, Eva Wolff, Jeremias Wohlschlaeger, Evelyn Heintschel von Heinegg, Dirk Schadendorf, Stefan Esser
OBJECTIVES: Rectal infections with Chlamydia trachomatis and/or Neisseria gonorrhoeae (CT/NG) are common in men who have sex with men (MSM) and are linked to HIV transmission. However, rectal CT/NG infections are often asymptomatic and it is not known how they contribute to HIV transmission. We assessed clinical and cytological signs of inflammation as well as rectal HIV-RNA in HIV-infected MSM with and without CT/NG infection. METHODS: 112 HIV-positive MSM with or without rectal symptoms and with or without antiretroviral therapy who underwent high-resolution anoscopy (HRA) at the proctological outpatient centre of the University Hospital Essen, Germany, between November 2013 and February 2014 were included in this cross-sectional study...
February 3, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29394362/prevalence-and-risk-factors-for-anal-human-papillomavirus-infection-in-human-immunodeficiency-virus-positive-men-who-have-sex-with-men
#10
Jean-Damien Combes, Isabelle Heard, Isabelle Poizot-Martin, Ana Canestri, Annie Lion, Lionel Piroth, Jean-Michel Didelot, Tristan Ferry, Olivier Patey, Lucie Marchand, Jean-Francois Flejou, Gary M Clifford, Isabelle Etienney
Background: We assessed prevalence and risk factors for anal human papillomavirus (HPV) in human immunodeficiency virus (HIV)-positive men who have sex with men (MSM), who are at high-risk of HPV-related anal cancer. Methods: APACHES is a multicentric, prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35 years. At baseline, participants underwent anal swabs for HPV and cytology, plus high-resolution anoscopy. High-risk HPV (HR-HPV) was tested by Cobas4800, with genotyping of HR-HPV positives by PapilloCheck...
April 23, 2018: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29208455/high-prevalence-and-incidence-of-hpv-related-anal-cancer-precursor-lesions-in-hiv-positive-women-in-the-late-haart-era
#11
Carmen Hidalgo-Tenorio, Samantha E de Jesus, Javier Esquivias, Juan Pasquau
INTRODUCTION: Anal cancer is one of the most common non-AIDS defining malignancies, especially in men who have sex with men and women living with HIV (WLHIV). OBJECTIVES: To evaluate the prevalence and incidence of precursor lesions (high-grade squamous intraepithelial lesions [HSIL]) and anal cancer in our cohort of women and to compare them to cervical lesions; to calculate the percentage of patients that acquire and clear oncogenic genotypes (HR-HPV) in the anal canal; and to determine predictive factors for anal HPV infection...
December 2, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29190817/screening-for-precancerous-anal-lesions-with-p16-ki67-immunostaining-in-hiv-infected-msm
#12
Sergio Serrano-Villar, Beatriz Hernández-Novoa, Amparo de Benito, Jorge Del Romero, Antonio Ocampo, José Ramón Blanco, Mar Masiá, Elena Sendagorta, Gonzalo Sanz, Santiago Moreno, José A Pérez-Molina
BACKGROUND: Screening of anal cancer in HIV-infected MSM with anal cytology results in high rates of false positive results and elevated burden of high-resolution anoscopies. High-risk HPV up-regulates p16 and Ki67 expression in epithelial cells. We assessed the usefulness of P16/Ki-67 immunostaining cytology for the diagnosis of precancerous anal lesions. METHODOLOGY: Cross-sectional multicenter study. Concomitant anal liquid cytology with p16/Ki-67 immunostaining and HRA with biopsy of acetowhite lugol-negative lesions was performed in HIV-infected MSM...
2017: PloS One
https://www.readbyqxmd.com/read/29172296/significance-of-the-cytological-signs-of-human-papillomavirus-infection-in-anal-pap-smears-of-human-immunodeficiency-virus-infected-japanese-men-who-have-sex-with-men
#13
Kaori Okayama, Mitsuaki Okodo, Hiroshi Kitamura, Ichiro Itoda
Purpose: The incidence of invasive anal cancer (IAC) has been increasing among human immunodeficiency virus (HIV)-positive men who have sex with men (MSM). Although cytological diagnosis is the modality of choice for screening cases of IAC, it is associated with lower sensitivity and specificity. Therefore, the present study aimed to evaluate new cytological signs of human papillomavirus (HPV) infection that may contribute to improving anal cytology. Methods: Anal cytology and HPV testing were performed using SurePath liquid-based cytology on samples obtained from 37 HIV-positive Japanese MSM...
November 26, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/29112567/a-pilot-study-of-the-prevalence-of-anal-human-papillomavirus-and-dysplasia-in-a-cohort-of-patients-with-ibd
#14
Ross D Cranston, Miguel Regueiro, Jana Hashash, Jonathan R Baker, Nicola Richardson-Harman, Laura Janocko, Ian McGowan
BACKGROUND: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD. OBJECTIVE: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. DESIGN: Patients had an anal examination before routine colonoscopy. SETTINGS: The study was conducted at a tertiary IBD referral center...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29093575/liver-transplant-recipients-have-a-higher-prevalence-of-anal-squamous-intraepithelial-lesions
#15
A Albuquerque, H Pessegueiro Miranda, J Lopes, J Gandara, S Rodrigues, R Gaspar, R Morais, R Ramalho, E Rodrigues-Pinto, H Cardoso, H Barroca, C C Dias, F Carneiro, G Macedo
BACKGROUND: Anal squamous intraepithelial lesions (ASIL) are precancerous lesions of anal squamous cell carcinoma, with a higher prevalence in immunosuppressed patients. There are some studies in kidney transplant recipients, but there is no information regarding prevalence in liver transplantation. Our aim was to evaluate the prevalence of ASIL in this setting. METHODS: Prospective case-control study involving liver transplant recipients without any other known risk factor for ASIL (n=59), which were compared with a healthy control group (n=57)...
December 5, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29080327/cross-sectional-study-of-anal-intraepithelial-lesions-in-women-with-cervical-neoplasia-without-hiv
#16
Sandra A Heráclio, Alex S R de Souza, Paulo R E de Souza, Leila Katz, Sergio F Lima Junior, Melania M R Amorim
OBJECTIVE: To evaluate the prevalence of anal intraepithelial lesions and associated risk factors in women with cervical neoplasia. METHODS: The present cross-sectional study enrolled patients with intraepithelial or invasive cervical neoplasia who had been referred to the lower genital tract pathology outpatient department of the Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil, between December 1, 2008, and December 31, 2009; patients with HIV infections were excluded...
February 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29074193/prevalence-and-risk-factors-associated-with-high-grade-anal-squamous-intraepithelial-lesions-hsil-ain2-and-hsil-ain3-in-homosexual-men
#17
Dorothy A Machalek, Fengyi Jin, I Mary Poynten, Richard J Hillman, David J Templeton, Carmella Law, Jennifer M Roberts, Sepehr N Tabrizi, Suzanne M Garland, Annabelle Farnsworth, Christopher K Fairley, Andrew E Grulich
BACKGROUND: Anal intraepithelial neoplasia grade 2 (AIN2) and AIN grade 3 (AIN3) are commonly grouped together as high grade squamous intraepithelial lesions (HSIL). We assessed risk factors for HSIL-AIN2 and HSIL-AIN3 in a cohort of homosexual men. METHODS: At the baseline visit in the Study for the Prevention of Anal Cancer (SPANC), all men completed a questionnaire and underwent anal swabbing for cytology and HPV genotyping, followed by high resolution anoscopy...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29053225/histological-outcomes-of-anal-high-grade-cytopredictions
#18
Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman
BACKGROUND: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old...
February 2018: Cancer Cytopathology
https://www.readbyqxmd.com/read/28991027/risk-factors-for-anal-high-grade-squamous-intraepithelial-lesions-in-hiv-positive-msm-is-targeted-screening-possible
#19
Matthijs L Siegenbeek van Heukelom, Elske Marra, Henry J C de Vries, Maarten F Schim van der Loeff, Jan M Prins
OBJECTIVE: HIV-positive MSM are at increased risk for developing anal squamous cell carcinoma. Detection of precursor lesions of anal cancer [anal high-grade squamous intraepithelial lesions (HSIL)] is cumbersome and expensive. Our objective was to identify potential risk factors for anal HSIL in HIV-positive MSM to develop more stringent screening criteria. DESIGN: We studied a cohort of MSM screened by high-resolution anoscopy at three HIV clinics in Amsterdam, the Netherlands...
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28953633/risk-factors-for-infection-by-oncogenic-human-papillomaviruses-in-hiv-positive-msm-patients-in-the-art-era-2010-2016
#20
Carmen Hidalgo-Tenorio, Concepción Gil-Anguita, Jessica Ramírez-Taboada, Javier Esquivias, Miguel A López-Ruz, Omar Mohamed Balgahata, Rosario Javier-Martinez, Juan Pasquau
Squamous cell carcinoma of anus (SCCA) is one of the most frequent non-AIDS-defining diseases in HIV patients, mainly in men who have sex with men (MSM), and it is associated with human papillomavirus (HPV) infection.To determine the prevalence of high-risk HPV (HR-HPV) genotypes, premalignant lesions (HSIL) and SCCA in a cohort of HIV-positive MSM; to study the distribution of HPV genotypes according to anal histology results; and to analyze risk factors for this infection.This prospective single-center study was conducted between May 2010 and September 2016...
September 2017: Medicine (Baltimore)
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