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https://www.readbyqxmd.com/read/28729879/safety-and-immunogenicity-of-the-quadrivalent-human-papillomavirus-qhpv-vaccine-in-hiv-positive-spanish-men-who-have-sex-with-men-msm
#1
Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz, Juan Pasquau
BACKGROUND: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of high-risk human papillomavirus (HR-HPV) were also determined, as well as risk factors associated with the presence of HR-HPV in anal mucosa. METHODS: This is a randomised, double blind, placebo-controlled trial of the quadrivalent HPV (qHPV) vaccine...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28723712/the-role-of-oncogenic-hpv-determination-for-diagnosis-of-high-grade-anal-intraepithelial-neoplasia-in-hiv-infected-msm
#2
Joaquin Burgos, J Hernández-Losa, S Landolfi, A Guelar, Mªc Dinares, J Villar, J Navarro, E Ribera, V Falcó, A Curran
OBJECTIVE: To assess the oncogenic human papillomavirus (HPV) determination and the co-testing HPV and anal cytology value to detect high-grade anal intraepithelial neoplasia (HGAIN) in a cohort of HIV-MSM. DESIGN AND METHODS: Prospective study of HIV-infected MSM who underwent screening for anal dysplasia. Screening program includes anal cytology, HPV testing, and high-resolution anoscopy (HRA) at each visit. Histological samples were obtained if suspicious lesions were revealed by HRA...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28720441/increased-tnf-alpha-and-stnfr2-levels-are-associated-with-high-grade-anal-squamous-intraepithelial-lesions-in-hiv-positive-patients-with-low-cd4-level
#3
Takeshi Haga, Jimmy T Efird, Sharof Tugizov, Joel M Palefsky
Compared with HIV-negative individuals, HIV-positive individuals have a higher prevalence of anogenital human papillomavirus (HPV) infection, the causative agent of anogenital cancer. TNF-alpha is a major proinflammatory cytokine. sTNFR2 is the soluble form of one of its receptors and is strongly expressed on stimulated lymphocytes. To further understand the role of TNF-alpha, sTNFR2 and other cytokines in the pathogenesis in HPV-related neoplasia, the profiles of serum cytokines in high-risk patients were analyzed for association with anal lesion status...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720147/safety-and-immunogenicity-of-the-quadrivalent-human-papillomavirus-qhpv-vaccine-in-hiv-positive-spanish-men-who-have-sex-with-men-msm
#4
Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz, Juan Pasquau
BACKGROUND: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of high-risk human papillomavirus (HR-HPV) were also determined, as well as risk factors associated with the presence of HR-HPV in anal mucosa. METHODS: This is a randomised, double blind, placebo-controlled trial of the quadrivalent HPV (qHPV) vaccine...
July 18, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28695429/cryotherapy-for-intra-and-perianal-high-grade-squamous-intraepithelial-lesions-in-hiv-positive-men-who-have-sex-with-men
#5
Matthijs L Siegenbeek van Heukelom, Karien C M Gosens, Jan M Prins, Henry J C de Vries
BACKGROUND: Available treatment options for anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men who have sex with men (MSM) are limited by low response rates and frequent recurrences. Cryotherapy is an established therapeutic option for several pre-malignant skin disorders. METHODS: This retrospective, non-randomized study included HIV-positive MSM who received intra- and/or perianal HSIL cryotherapy treatment between 30 December 2008 and 23 April 2015...
July 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28644711/screening-for-squamous-cell-anal-cancer-in-hiv-positive-patients-a-five-year-experience
#6
Chiara Santorelli, Cosimo Alex Leo, Jonathan D Hodgkinson, Franco Baldelli, Francesco Cantarella, Emanuel Cavazzoni
AIM: Potential screening modalities for early diagnosis of squamous cell anal cancer (SCC) in HIV patients include digital anorectal examination (DARE), anal Papanicolaou testing (Pap test), human papilloma virus (HPV) co-testing, and high-resolution anoscopy. The aim of this study was to demonstrate the results of a five-year screening program for SCC in HIV patients. MATERIALS AND METHODS: We conducted a retrospective study on 204 HIV patients who underwent a screening program for SCC from October 2010 to January 2015...
June 23, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28530494/review-anal-intraepithelial-neoplasia-in-hiv-infected-men-who-have-sex-with-men-is-screening-and-treatment-justified
#7
Peter Wasserman, David S Rubin, Glenn Turett
Anal squamous cell carcinoma (SCC) is the fourth most prevalent cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Human papillomavirus (HPV) has been detected in over 90% of anal carcinoma biopsy specimens from MSM, and is considered a necessary, but alone, insufficient factor for carcinogenesis. Anal intraepithelial neoplasia (AIN) may be precursive for SCC, and screening cytology with referral of persons with abnormality for high-resolution anoscopy-guided biopsy, and AIN treatment, has been recommended for prevention...
June 2017: AIDS Patient Care and STDs
https://www.readbyqxmd.com/read/28255426/anal-intraepithelial-neoplasia-a-review-of-diagnosis-and-management
#8
REVIEW
Joseph R Roberts, Lacey L Siekas, Andrew M Kaz
Anal intraepithelial neoplasia (AIN) is a premalignant lesion of the anal mucosa that is a precursor to anal cancer. Although anal cancer is relatively uncommon, rates of this malignancy are steadily rising in the United States, and among certain high risk populations the incidence of anal cancer may exceed that of colon cancer. Risk factors for AIN and anal cancer consist of clinical factors and behaviors that are associated with the acquisition and persistence of human papilloma virus (HPV) infection. The strongest HPV-associated risk factors are HIV infection, receptive anal intercourse, and high risk sexual behavior...
February 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28252530/risk-factors-of-high-grade-anal-intraepithelial-neoplasia-recurrence-in-hiv-infected-msm
#9
Joaquin Burgos, Adria Curran, Stefania Landolfi, Ana Guelar, Lucia Miguel, MaCarmen Dinares, Judith Villar, Jordi Navarro, Javier Hernandez-Losa, Vicenç Falcó
OBJECTIVE: To assess risk factors of high-grade anal intraepithelial neoplasia (HGAIN) recurrence in a cohort of HIV-infected MSM. DESIGN AND METHODS: Consecutive HIV-infected 100 MSM with a history of successfully treated intra-anal HGAIN with electrocautery were followed with anal cytology, human papillomavirus (HPV) determination, and high-resolution anoscopy (HRA) at 3-6-month intervals. HGAIN recurrence was analyzed using Kaplan-Meier analysis. Risk factors of recurrence were assessed using Cox proportional hazards regression...
June 1, 2017: AIDS
https://www.readbyqxmd.com/read/28229612/preliminary-results-of-a-screening-program-for-anal-cancer-and-its-precursors-for-hiv-infected-men-who-have-sex-with-men-in-vigo-spain
#10
Mauricio Iribarren Díaz, Antonio Ocampo Hermida, Joaquín González-Carreró Fojón, Rebeca Longueira Suárez, Alberto Rivera Gallego, Enrique Casal Núñez, Antón Ocampo Álvarez, Edward R Cachay
BACKGROUND: Men who have sex with men (MSM) infected with human immunodeficiency virus (HIV) have the highest risk of developing anal cancer (AC). The objective of this study was to describe our screening implementation program in this population, and report the prevalence of human papillomavirus (HPV) anal infection, and cytological and histological findings in a Spanish medium-size community (Vigo, Spain). METHOD: Prospective cohort analysis of 240 HIV-infected MSM...
April 2017: Revista Española de Enfermedades Digestivas
https://www.readbyqxmd.com/read/28161543/anal-study-in-immunocompetent-women-with-human-papillomavirus-related-lower-genital-tract-pathology
#11
Concepción Donaire, Marcos Reillo, Juan C Martínez-Escoriza, José A López-Fernández
OBJETIVE: To estimate the prevalence of anal dysplasia in immunocompetent women with cervical intraepithelial dysplasia. STUDY DESIGN: We did a prospective cohort study, in which we enrolled 166 women with gynecological pathology related to human papilloma virus (HPV) infection. All patients underwent an anal cytology and HPV detection. Statistical analysis with a 95% confidence interval was used for prevalence calculations. A Χ2 test and Fisher's exact one were used to determine differences between groups of qualitative variables...
January 19, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28141783/prevalence-of-anal-hpv-and-anal-dysplasia-in-hiv-infected-women-from-johannesburg-south-africa
#12
Bridgette J Goeieman, Cynthia S Firnhaber, Eefje Jong, Pam Michelow, Patricia Kegorilwe, Avril Swarts, Anna-Lise Williamson, Bruce Allan, Jennifer S Smith, Timothy J Wilkin
BACKGROUND: Anal cancer is a relatively common cancer among HIV-infected populations. There are limited data on the prevalence of anal high-risk human papillomavirus (HR-HPV) infection and anal dysplasia in HIV-infected women from resource-constrained settings. METHODS: A cross-sectional study of HIV-infected women aged 25-65 years recruited from an HIV clinic in Johannesburg, South Africa. Cervical and anal swabs were taken for conventional cytology and HR-HPV testing...
July 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28121939/multiple-preinvasive-and-invasive-hpv-related-lesions-of-the-anogenital-tract-in-a-female-patient-with-hiv-infection-a-case-report
#13
Nicolò Clemente, Lara Alessandrini, Emanuela Vaccher, Antonino De Paoli, Monica Buttignol, Vincenzo Canzonieri, Francesco Sopracordevole
RATIONALE: Patients with human immunodeficiency virus (HIV) infection have been shown to be at increased risk for high-risk human papillomavirus (HR-HPV) infection of the anogenital tract. Furthermore, in the last decades, the introduction of highly active antiretroviral therapy (HAART) has increased the longevity of these patients who now live long enough to develop HPV-related cancers; hence, the impact of HPV infection on HIV-positive patients is of increasing concern. PATIENT CONCERNS: We reported the case of an HIV-positive female patient on HAART with a good virological and immunological response and with a long history of HPV-related intraepithelial and invasive lesions of the anogenital tract...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28091842/squamous-cell-dysplasia-in-the-proximal-rectum-of-three-patients-treated-for-ulcerative-colitis-on-immunomodulators
#14
James G Connolly, Stephen E Goldstone
BACKGROUND: Anal canal high-grade squamous intraepithelial lesion (HSIL) is the precursor to anal cancer. Immunocompromised patients are at increased risk and disease is usually within 3 cm from the anal verge. High-resolution anoscopy (HRA) with an 8-cm anoscope is used to identify and guide cautery treatment of HSIL. PURPOSE: We report three patients with a long-term history of ulcerative colitis (UC) treated with systemic immunomodulators who developed proximally located rectal HSIL...
May 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27965301/high-rates-of-anal-high-grade-squamous-intraepithelial-lesions-in-hiv-infected-women-who-do-not-meet-screening-guidelines
#15
Michael Gaisa, Fanny Ita-Nagy, Keith Sigel, Yotam Arens, Mary Ann Hennessy, Gabriela Rodriguez-Caprio, Michael Mullen, Judith A Aberg, Michelle Cespedes
BACKGROUND: Human immunodeficiency virus (HIV)-infected women have a higher burden of anal high-grade squamous intraepithelial lesions (HSIL) and anal cancer (AC) compared with HIV-uninfected women. Guidelines for AC screening in this population are heterogeneous. Here we report outcomes and risk factors for anal HSIL following implementation of universal AC screening offered to all HIV-infected women. METHODS: Data from women who underwent AC screening with anal cytology from April 2009 to July 2014 were analyzed...
February 1, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27845952/human-papillomavirus-as-a-cause-of-anal-cancer-and-the-role-of-screening
#16
Karien C M Gosens, Olivier Richel, Jan M Prins
PURPOSE OF REVIEW: Anal cancer is a serious health problem in HIV-positive men who have sex with men, and precursor lesions, anal intraepithelial neoplasia, are well defined. Given the similarities with cervical cancer, screening for and treatment of anal intraepithelial neoplasia might prevent anal cancer. Screening programmes should meet the Wilson and Jungner criteria. We used these criteria to evaluate the current body of evidence supporting a screening programme for anal dysplasia...
February 2017: Current Opinion in Infectious Diseases
https://www.readbyqxmd.com/read/27806411/anal-chromoendoscopy-using-gastroenterological-video-endoscopes-a-new-method-to-perform-high-resolution-anoscopy-for-diagnosing-intraepithelial-neoplasia-and-anal%C3%A2-carcinoma-in-hiv-infected-patients
#17
Mark Oette, Ulrike Wieland, Marko Schünemann, Johannes Haes, Stefan Reuter, Björn Erik Ole Jensen, Abdurrahman Sagir, Herbert Pfister, Dieter Häussinger
Introduction Anal carcinoma represents an increasing problem in HIV-infected patients. Anal intraepithelial neoplasia (AIN), the precursor lesion, is currently diagnosed by high-resolution anoscopy (HRA) using optical magnification derived from gynecological colposcopy. This prospective study evaluates anal chromoendoscopy (ACE) using standard gastroenterological video-endoscopes in diagnosing AIN. Methods After clinical examination, proctoscopy and surface staining with acetic acid followed by Lugol's solution, ACE was performed with a mucosectomy cap on the tip of the endoscope...
January 2017: Zeitschrift Für Gastroenterologie
https://www.readbyqxmd.com/read/27770248/a-trial-of-radiofrequency-ablation-for-anal-intraepithelial-neoplasia
#18
Robert N Goldstone, Shirin R Hasan, Steven Drury, Teresa M Darragh, Annemieke van Zante, Stephen E Goldstone
PURPOSE: Radiofrequency ablation (RFA) effectively treats esophageal high-grade dysplasia, but its efficacy in treating anal canal high-grade squamous intraepithelial lesions (HSILs) is unsubstantiated. This prospective study assessed the safety and efficacy of applying hemi-circumferential RFA to anal canal HSIL. METHODS: Twenty-one HIV-negative participants with HSIL occupying ≤ half the anal canal circumference were treated with hemi-circumferential anal canal RFA...
March 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/27600328/screening-for-anal-intraepithelial-neoplasia-high-resolution-anoscopy-guided-biopsy-of-the-anal-canal
#19
J B Repiso Jiménez, L Padilla España, T Fernández Morano, M de Troya Martín
No abstract text is available yet for this article.
January 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27561134/2016-ians-international-guidelines-for-practice-standards-in-the-detection-of-anal-cancer-precursors
#20
Richard John Hillman, Tamzin Cuming, Teresa Darragh, Mayura Nathan, Michael Berry-Lawthorn, Stephen Goldstone, Carmella Law, Joel Palefsky, Luis F Barroso, Elizabeth A Stier, Céline Bouchard, Justine Almada, Naomi Jay
OBJECTIVES: To define minimum standards for provision of services and clinical practice in the investigation of anal cancer precursors. METHODS: After initial face to face meetings of experts at the International Papillomavirus meeting in Lisbon, September 17 to 21, 2015, a first version was drafted and sent to key stakeholders. A complete draft was reviewed by the Board of the International Anal Neoplasia Society (IANS) and uploaded to the IANS Web site for all members to provide comments...
October 2016: Journal of Lower Genital Tract Disease
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