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https://www.readbyqxmd.com/read/29112567/a-pilot-study-of-the-prevalence-of-anal-human-papillomavirus-and-dysplasia-in-a-cohort-of-patients-with-ibd
#1
Ross D Cranston, Miguel Regueiro, Jana Hashash, Jonathan R Baker, Nicola Richardson-Harman, Laura Janocko, Ian McGowan
BACKGROUND: Defective cell-mediated immunity increases the risk of human papillomavirus-associated anal dysplasia and cancer. There is limited information on anal canal disease in patients with IBD. OBJECTIVE: The purpose of this study was to assess anal/vaginal human papillomavirus and anal dysplasia prevalence in patients with IBD. DESIGN: Patients had an anal examination before routine colonoscopy. SETTINGS: The study was conducted at a tertiary IBD referral center...
December 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29093575/liver-transplant-recipients-have-a-higher-prevalence-of-anal-squamous-intraepithelial-lesions
#2
A Albuquerque, H Pessegueiro Miranda, J Lopes, J Gandara, S Rodrigues, R Gaspar, R Morais, R Ramalho, E Rodrigues-Pinto, H Cardoso, H Barroca, C C Dias, F Carneiro, G Macedo
BACKGROUND: Anal squamous intraepithelial lesions (ASIL) are precancerous lesions of anal squamous cell carcinoma, with a higher prevalence in immunosuppressed patients. There are some studies in kidney transplant recipients, but there is no information regarding prevalence in liver transplantation. Our aim was to evaluate the prevalence of ASIL in this setting. METHODS: Prospective case-control study involving liver transplant recipients without any other known risk factor for ASIL (n=59), which were compared with a healthy control group (n=57)...
October 31, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29080327/cross-sectional-study-of-anal-intraepithelial-lesions-in-women-with-cervical-neoplasia-without-hiv
#3
Sandra A Heráclio, Alex S R de Souza, Paulo R E de Souza, Leila Katz, Sergio F Lima Junior, Melania M R Amorim
OBJECTIVE: To evaluate the prevalence of anal intraepithelial lesions and associated risk factors in women with cervical neoplasia. METHODS: The present cross-sectional study enrolled patients with intraepithelial or invasive cervical neoplasia who had been referred to the lower genital tract pathology outpatient department of the Instituto de Medicina Integral Prof. Fernando Figueira, Recife, Brazil, between December 1, 2008, and December 31, 2009; patients with HIV infections were excluded...
October 28, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29074193/prevalence-and-risk-factors-associated-with-high-grade-anal-squamous-intraepithelial-lesions-hsil-ain2-and-hsil-ain3-in-homosexual-men
#4
Dorothy A Machalek, Fengyi Jin, I Mary Poynten, Richard J Hillman, David J Templeton, Carmella Law, Jennifer M Roberts, Sepehr N Tabrizi, Suzanne M Garland, Annabelle Farnsworth, Christopher K Fairley, Andrew E Grulich
BACKGROUND: Anal intraepithelial neoplasia grade 2 (AIN2) and AIN grade 3 (AIN3) are commonly grouped together as high grade squamous intraepithelial lesions (HSIL). We assessed risk factors for HSIL-AIN2 and HSIL-AIN3 in a cohort of homosexual men. METHODS: At the baseline visit in the Study for the Prevention of Anal Cancer (SPANC), all men completed a questionnaire and underwent anal swabbing for cytology and HPV genotyping, followed by high resolution anoscopy...
December 2016: Papillomavirus Research
https://www.readbyqxmd.com/read/29053225/histological-outcomes-of-anal-high-grade-cytopredictions
#5
Jennifer Margaret Roberts, Fengyi Jin, Isobel Mary Poynten, Carmella Law, David James Templeton, Julia Kathleen Thurloe, Suzanne Marie Garland, Andrew Edwin Grulich, Annabelle Farnsworth, Richard John Hillman
BACKGROUND: Longitudinal studies of histological outcomes after anal cytological screening in men who have sex with men (MSM) are rare. This study measured the positive predictive values (PPVs) of each level of baseline cytological abnormality in MSM in Sydney, Australia, over a 12-month period. METHODS: The Study of the Prevention of Anal Cancer is a 3-year prospective study of the natural history of anal human papillomavirus infection in MSM at least 35 years old...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/28991027/risk-factors-for-anal-high-grade-squamous-intraepithelial-lesions-in-hiv-positive-msm-is-targeted-screening-possible
#6
Matthijs L Siegenbeek van Heukelom, Elske Marra, Henry J C de Vries, Maarten F Schim van der Loeff, Jan M Prins
OBJECTIVE: HIV-positive MSM are at increased risk for developing anal squamous cell carcinoma. Detection of precursor lesions of anal cancer [anal high-grade squamous intraepithelial lesions (HSIL)] is cumbersome and expensive. Our objective was to identify potential risk factors for anal HSIL in HIV-positive MSM to develop more stringent screening criteria. DESIGN: We studied a cohort of MSM screened by high-resolution anoscopy at three HIV clinics in Amsterdam, the Netherlands...
October 23, 2017: AIDS
https://www.readbyqxmd.com/read/28953633/risk-factors-for-infection-by-oncogenic-human-papillomaviruses-in-hiv-positive-msm-patients-in-the-art-era-2010-2016
#7
Carmen Hidalgo-Tenorio, Concepción Gil-Anguita, Jessica Ramírez-Taboada, Javier Esquivias, Miguel A López-Ruz, Omar Mohamed Balgahata, Rosario Javier-Martinez, Juan Pasquau
Squamous cell carcinoma of anus (SCCA) is one of the most frequent non-AIDS-defining diseases in HIV patients, mainly in men who have sex with men (MSM), and it is associated with human papillomavirus (HPV) infection.To determine the prevalence of high-risk HPV (HR-HPV) genotypes, premalignant lesions (HSIL) and SCCA in a cohort of HIV-positive MSM; to study the distribution of HPV genotypes according to anal histology results; and to analyze risk factors for this infection.This prospective single-center study was conducted between May 2010 and September 2016...
September 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28953128/incidence-of-anal-dysplasia-in-a-population-of-high-risk-women-observations-at-a-cervical-pathology-unit
#8
María de Los Reyes Oliver-Pérez, Victoria Bravo Violeta, Beatriz Legorburu Alonso, Diana Betancor Pérez, Vicente Bebia Conesa, Jesús S Jiménez López
OBJECTIVES: This study aimed to evaluate the incidence of anal dysplasia in women at high risk of developing those lesions and to assess the relationships between positive anal cytology and different risk factors. MATERIALS AND METHODS: We performed an observational cross-sectional study involving a patient survey and chart review. The study was conducted at the cervical pathology unit at the Hospital Universitario 12 de Octubre, Madrid, Spain, from 2011 to 2015...
October 2017: Journal of Lower Genital Tract Disease
https://www.readbyqxmd.com/read/28950043/management-of-precancerous-anal-intraepithelial-lesions-in-human-immunodeficiency-virus-positive-men-who-have-sex-with-men-clinical-effectiveness-and-cost-effectiveness
#9
Ashish A Deshmukh, Elizabeth Y Chiao, Scott B Cantor, Elizabeth A Stier, Stephen E Goldstone, Alan G Nyitray, Timothy Wilkin, Xiaojie Wang, Jagpreet Chhatwal
BACKGROUND: Human immunodeficiency virus (HIV)-positive men who have sex with men (MSM) are at disproportionately high risk for anal cancer. There is no definitive approach to the management of high-grade squamous intraepithelial lesions (HSIL), which are precursors of anal cancer, and evidence suggests that posttreatment adjuvant quadrivalent human papillomavirus (qHPV) vaccination improves HSIL treatment effectiveness. The objectives of this study were to evaluate the optimal HSIL management strategy with respect to clinical effectiveness and cost-effectiveness and to identify the optimal age for initiating HSIL management...
December 1, 2017: Cancer
https://www.readbyqxmd.com/read/28931234/the-evva-cohort-study-anal-and-cervical-type-specific-human-papillomavirus-prevalence-persistence-and-cytologic-findings-in-women-living-with-hiv
#10
Alexandra de Pokomandy, Elaina Kaufman, Christina de Castro, Marie-Hélène Mayrand, Ann N Burchell, Marina Klein, Louise Charest, Manon Auger, Sophie Rodrigues-Coutlée, François Coutlée
Background: The risk of anal cancer due to high-risk human papillomavirus (HR-HPV) is higher in women living with human immunodeficiency virus (HIV) than in the general population. We present findings of cervical and anal HPV and cytologic tests at baseline in the EVVA cohort study and HPV persistence data 6 months after baseline. Methods: Semiannual visits included questionnaires, chart reviews, cervical/anal cytologic and cervical/anal HPV testing for 2 years...
August 15, 2017: Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28926406/risk-factors-for-anal-hsil-in-hiv-positive-msm-is-targeted-screening-possible
#11
Matthijs L Siegenbeek van Heukelom, Elske Marra, Henry J C de Vries, Maarten F Schim van der Loeff, Jan M Prins
OBJECTIVE: HIV-positive men-who-have-sex-with-men (MSM) are at increased risk for developing anal squamous cell carcinoma (aSCC). Detection of precursor lesions of anal cancer (anal high-grade squamous intraepithelial lesions; HSIL) is cumbersome and expensive. Our objective was to identify potential risk factors for anal HSIL in HIV-positive MSM to develop more stringent screening criteria. DESIGN: We studied a cohort of MSM screened by high-resolution anoscopy (HRA) at three HIV clinics in Amsterdam, the Netherlands...
September 18, 2017: AIDS
https://www.readbyqxmd.com/read/28891852/condyloma-acuminatum-anal-intraepithelial-neoplasia-and-anal-cancer-in-the-setting-of-hiv-do-we-really-understand-the-risk
#12
Edward A Fazendin, Alexander J Crean, Jessica M Fazendin, Robert J Kucejko, Harkenwar S Gill, Juan L Poggio, David E Stein
BACKGROUND: The gold standard for surveillance of patients with anal lesions is unclear. OBJECTIVE: The aim of this study was to stratify patients for risk of progression of disease and to determine appropriate intervals for surveillance of patients with anal disease. DESIGN: This was a retrospective chart review for patients treated for anal lesions between 2007 and 2014. Only patients with ≥1 year of follow-up from index evaluation, pathology, documented physical examination, and anoscopy findings were included for analysis...
October 2017: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/28857936/brief-report-radiofrequency-ablation-therapy-for-anal-intraepithelial-neoplasia-results-from-a-single-center-prospective-pilot-study-in-hiv-participants
#13
Robert N Goldstone, Shirin R Hasan, Stephen E Goldstone
BACKGROUND: HIV-positive individuals have high incidence of anal high-grade squamous intraepithelial lesions (HSIL) at the squamocolumnar junction (SCJ), which can progress to cancer. Focal radiofrequency ablation (RFA) treats HSIL, but metachronous recurrence remains high and may be improved with circumferential treatment. SETTING: The study was performed at a single center. METHODS: This was a prospective trial of circumferential anal RFA using Barrx 60 RFA focal catheters in participants with ≥1 anal SCJ HSIL...
December 1, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28729879/safety-and-immunogenicity-of-the-quadrivalent-human-papillomavirus-qhpv-vaccine-in-hiv-positive-spanish-men-who-have-sex-with-men-msm
#14
Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz, Juan Pasquau
BACKGROUND: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of high-risk human papillomavirus (HR-HPV) were also determined, as well as risk factors associated with the presence of HR-HPV in anal mucosa. METHODS: This is a randomised, double blind, placebo-controlled trial of the quadrivalent HPV (qHPV) vaccine...
2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28723712/the-role-of-oncogenic-hpv-determination-for-diagnosis-of-high-grade-anal-intraepithelial-neoplasia-in-hiv-infected-msm
#15
Joaquin Burgos, J Hernández-Losa, S Landolfi, A Guelar, Mªc Dinares, J Villar, J Navarro, E Ribera, V Falcó, A Curran
OBJECTIVE: To assess the oncogenic human papillomavirus (HPV) determination and the co-testing HPV and anal cytology value to detect high-grade anal intraepithelial neoplasia (HGAIN) in a cohort of HIV-MSM. DESIGN AND METHODS: Prospective study of HIV-infected MSM who underwent screening for anal dysplasia. Screening program includes anal cytology, HPV testing, and high-resolution anoscopy (HRA) at each visit. Histological samples were obtained if suspicious lesions were revealed by HRA...
July 18, 2017: AIDS
https://www.readbyqxmd.com/read/28720441/increased-tnf-alpha-and-stnfr2-levels-are-associated-with-high-grade-anal-squamous-intraepithelial-lesions-in-hiv-positive-patients-with-low-cd4-level
#16
Takeshi Haga, Jimmy T Efird, Sharof Tugizov, Joel M Palefsky
Compared with HIV-negative individuals, HIV-positive individuals have a higher prevalence of anogenital human papillomavirus (HPV) infection, the causative agent of anogenital cancer. TNF-alpha is a major proinflammatory cytokine. sTNFR2 is the soluble form of one of its receptors and is strongly expressed on stimulated lymphocytes. To further understand the role of TNF-alpha, sTNFR2 and other cytokines in the pathogenesis in HPV-related neoplasia, the profiles of serum cytokines in high-risk patients were analyzed for association with anal lesion status...
June 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/28720147/safety-and-immunogenicity-of-the-quadrivalent-human-papillomavirus-qhpv-vaccine-in-hiv-positive-spanish-men-who-have-sex-with-men-msm
#17
Carmen Hidalgo-Tenorio, Jessica Ramírez-Taboada, Concepción Gil-Anguita, Javier Esquivias, Mohamed Omar-Mohamed-Balgahata, Antonio SamPedro, Miguel Lopez-Ruz, Juan Pasquau
BACKGROUND: Safety and immunogenicity of the quadrivalent human papillomavirus (qHPV) vaccine were evaluated in HIV-positive Spanish MSM. The prevalence of High Squamous Intraepithelial Lesions (HSIL) and genotypes of high-risk human papillomavirus (HR-HPV) were also determined, as well as risk factors associated with the presence of HR-HPV in anal mucosa. METHODS: This is a randomised, double blind, placebo-controlled trial of the quadrivalent HPV (qHPV) vaccine...
July 18, 2017: AIDS Research and Therapy
https://www.readbyqxmd.com/read/28695429/cryotherapy-for-intra-and-perianal-high-grade-squamous-intraepithelial-lesions-in-hiv-positive-men-who-have-sex-with-men
#18
Matthijs L Siegenbeek van Heukelom, Karien C M Gosens, Jan M Prins, Henry J C de Vries
BACKGROUND: Available treatment options for anal high-grade squamous intraepithelial lesions (HSIL) in HIV-positive men who have sex with men (MSM) are limited by low response rates and frequent recurrences. Cryotherapy is an established therapeutic option for several pre-malignant skin disorders. METHODS: This retrospective, non-randomized study included HIV-positive MSM who received intra- and/or perianal HSIL cryotherapy treatment between 30 December 2008 and 23 April 2015...
July 10, 2017: American Journal of Clinical Dermatology
https://www.readbyqxmd.com/read/28644711/screening-for-squamous-cell-anal-cancer-in-hiv-positive-patients-a-five-year-experience
#19
Chiara Santorelli, Cosimo Alex Leo, Jonathan D Hodgkinson, Franco Baldelli, Francesco Cantarella, Emanuel Cavazzoni
AIM: Potential screening modalities for early diagnosis of squamous cell anal cancer (SCC) in HIV patients include digital anorectal examination (DARE), anal Papanicolaou testing (Pap test), human papilloma virus (HPV) co-testing, and high-resolution anoscopy. The aim of this study was to demonstrate the results of a five-year screening program for SCC in HIV patients. MATERIALS AND METHODS: We conducted a retrospective study on 204 HIV patients who underwent a screening program for SCC from October 2010 to January 2015...
June 23, 2017: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/28530494/review-anal-intraepithelial-neoplasia-in-hiv-infected-men-who-have-sex-with-men-is-screening-and-treatment-justified
#20
Peter Wasserman, David S Rubin, Glenn Turett
Anal squamous cell carcinoma (SCC) is the fourth most prevalent cancer in human immunodeficiency virus (HIV)-infected men who have sex with men (MSM). Human papillomavirus (HPV) has been detected in over 90% of anal carcinoma biopsy specimens from MSM, and is considered a necessary, but alone, insufficient factor for carcinogenesis. Anal intraepithelial neoplasia (AIN) may be precursive for SCC, and screening cytology with referral of persons with abnormality for high-resolution anoscopy-guided biopsy, and AIN treatment, has been recommended for prevention...
June 2017: AIDS Patient Care and STDs
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