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High resolution anoscopy

Robert N Goldstone, Shirin R Hasan, Steven Drury, Teresa M Darragh, Annemieke van Zante, Stephen E Goldstone
PURPOSE: Radiofrequency ablation (RFA) effectively treats esophageal high-grade dysplasia, but its efficacy in treating anal canal high-grade squamous intraepithelial lesions (HSILs) is unsubstantiated. This prospective study assessed the safety and efficacy of applying hemi-circumferential RFA to anal canal HSIL. METHODS: Twenty-one HIV-negative participants with HSIL occupying ≤ half the anal canal circumference were treated with hemi-circumferential anal canal RFA...
October 21, 2016: International Journal of Colorectal Disease
J B Repiso Jiménez, L Padilla España, T Fernández Morano, M de Troya Martín
No abstract text is available yet for this article.
September 3, 2016: Actas Dermo-sifiliográficas
Richard John Hillman, Tamzin Cuming, Teresa Darragh, Mayura Nathan, Michael Berry-Lawthorn, Stephen Goldstone, Carmella Law, Joel Palefsky, Luis F Barroso, Elizabeth A Stier, Céline Bouchard, Justine Almada, Naomi Jay
OBJECTIVES: To define minimum standards for provision of services and clinical practice in the investigation of anal cancer precursors. METHODS: After initial face to face meetings of experts at the International Papillomavirus meeting in Lisbon, September 17 to 21, 2015, a first version was drafted and sent to key stakeholders. A complete draft was reviewed by the Board of the International Anal Neoplasia Society (IANS) and uploaded to the IANS Web site for all members to provide comments...
October 2016: Journal of Lower Genital Tract Disease
Jill Tinmouth, Valentina Peeva, Henok Amare, Sandra Blitz, Janet Raboud, Marie Sano, Leah Steele, Irving E Salit
BACKGROUND: High-grade intraepithelial neoplasia is known to progress to invasive squamous-cell carcinoma of the anus. There are limited reports on the rate of progression from high-grade intraepithelial neoplasia to anal cancer in HIV-positive men who have sex with men. OBJECTIVES: The purpose of this study was to describe in HIV-positive men who have sex with men with perianal high-grade intraepithelial neoplasia the rate of progression to anal cancer and the factors associated with that progression...
September 2016: Diseases of the Colon and Rectum
Darin Ruanpeng, Suwat Chariyalertsak, Quanhathai Kaewpoowat, Taweewat Supindham, Jongkolnee Settakorn, Kornkanok Sukpan, Utaiwan Utaipat, Toshiyuki Miura, Natthapol Kosashunhanan, Pongpun Saokhieo, Radchanok Songsupa, Antika Wongthanee
BACKGROUND: Anal cancer, one of human papillomavirus (HPV) related malignancies, has increased in recent decades, particularly among men who have sex with men (MSM) and HIV-infected (HIV+) persons. We aimed to explore the prevalence of anal squamous intraepithelial lesions (ASIL) using Papanicolau (Pap) screening among MSM in northern Thailand and its associated factors. METHODS: Two hundreds MSM aged ≥18 years reporting receptive anal intercourse in the prior 6 months were recruited from July 2012 through January 2013...
2016: PloS One
Dorothy A Machalek, I Mary Poynten, Fengyi Jin, Richard J Hillman, David J Templeton, Carmella Law, Jennifer M Roberts, Sepehr N Tabrizi, Suzanne M Garland, Annabelle Farnsworth, Christopher K Fairley, Andrew E Grulich
BACKGROUND: There is debate about the accuracy of anal cytology and high-resolution anoscopy (HRA), in the diagnosis of anal human papillomavirus (HPV)-related squamous intraepithelial lesions (SIL). Few studies have performed both simultaneously in a large sample of high-risk individuals. METHODS: At baseline in a community-based cohort of HIV-infected and uninfected homosexual men ages ≥35 years in Sydney, Australia, all men underwent anal swabbing for cytology and HPV genotyping, and HRA-guided biopsy...
July 2016: Cancer Epidemiology, Biomarkers & Prevention
Jennifer M Roberts, Fengyi Jin, Julia K Thurloe, Deborah Ekman, Marjorie K Adams, Ross L McDonald, Clare Biro, I Mary Poynten, Andrew E Grulich, Annabelle Farnsworth
BACKGROUND: In a cytology-based screening program intended to prevent anal cancer, the anal transformation zone (TZ) should be adequately sampled because it is the site most susceptible to the development of the cancer precursor, high-grade squamous intraepithelial lesion (HSIL). An adequate TZ component is defined as comprising at least 10 rectal columnar or squamous metaplastic cells. In the current study, the authors examined whether the presence of a TZ component in anal cytology correlated with the detection of histological HSIL...
August 2016: Cancer Cytopathology
Steve Simpson, Penny Blomfield, Alyssa Cornall, Sepehr N Tabrizi, Leigh Blizzard, Richard Turner
BACKGROUND: Anal cancer is a human papillomavirus (HPV)-mediated neoplasia of the anal squamous epithelium. Anal cancer is much more common among women, particularly those with a previous high-grade gynaecological neoplasia. METHODS: Cross-sectional study of women with a previous HPV-mediated gynaecological neoplasia in Tasmania, Australia. Women presenting for follow-up gynaecological care had anal swab samples taken for anal cytology by Hologic Liquid ThinPrep, followed by HPV genotyping...
June 2016: Cancer Epidemiology
Beth Cronin, Amy Bregar, Christine Luis, Steven Schechter, Paul Disilvestro, Latha Pisharodi, C James Sung, Christina Raker, Melissa Clark, Katina Robison
OBJECTIVE: To compare the prevalence of abnormal anal cytology, high-risk anal HPV and biopsy proven anal dysplasia among women with a history of lower genital tract malignancy compared to those with dysplasia. METHODS: A prospective cohort study was performed from December 2012 to February 2014 at outpatient clinics at an academic medical center. Women with a history of high-grade cervical, vulvar, or vaginal dysplasia, or malignancy were recruited. Anal cytology and HPV genotyping were performed...
June 2016: Gynecologic Oncology
Agnès Libois, Francesco Feoli, Marcel Nkuize, Marc Delforge, Deborah Konopnicki, Nathan Clumeck, Stéphane De Wit
OBJECTIVE: HIV-positive men who have sex with men (MSM) are at increased risk of anal cancer. We evaluate the risk factors for anal high-grade squamous intraepithelial lesion (HSIL) (the precursor of anal cancer) in HIV-positive MSM. METHODS: In this cross-sectional study within a cohort, 320 HIV-positive MSM were screened by anal cytology followed by high-resolution anoscopy (HRA) in case of abnormal cytology. Risk factors for anal HSIL were analysed. RESULTS: Men were mostly middle-aged Caucasians with median CD4+ T lymphocytes of 638 cells/µL, 87% on combined antiretroviral therapy (cART) for a median of 5 years...
March 30, 2016: Sexually Transmitted Infections
Kevin C Long, Raman Menon, Amir Bastawrous, Richard Billingham
The prevalence of anal intraepithelial neoplasia has been increasing, especially in high-risk patients, including men who have sex with men, human immunodeficiency virus positive patients, and those who are immunosuppressed. Several studies with long-term follow-up have suggested that rate of progression from high-grade squamous intraepithelial lesions to invasive anal cancer is ∼ 5%. This number is considerably higher for those at high risk. Anal cytology has been used to attempt to screen high-risk patients for disease; however, it has been shown to have very little correlation to actual histology...
March 2016: Clinics in Colon and Rectal Surgery
Fengyi Jin, Andrew E Grulich, I Mary Poynten, Richard J Hillman, David J Templeton, Carmella L H Law, Annabelle Farnsworth, Suzanne M Garland, Christopher K Fairley, Jennifer M Roberts
BACKGROUND: Studies regarding the performance of anal cytology in which both the screening test (cytology) and the diagnostic test (high-resolution anoscopy [HRA]) are performed in all members of a screening population are rare. The authors evaluated the performance of liquid-based anal cytology in a cohort of homosexual men in Sydney, New South Wales, Australia. METHODS: The Study of the Prevention of Anal Cancer (SPANC) is a 3-year prospective study of the natural history of anal human papillomavirus infection in homosexual men aged ≥35 years...
June 2016: Cancer Cytopathology
Joshua Gulvin, David M Aboulafia
People living with HIV/AIDS (PLWHA) are surviving longer, with an increased risk of cancer. Cancer screening strategies in PLWHA are lacking. We describe the case of a woman with a history of AIDS, who had a nondetectable viral load on treatment. She is an activist, promoting HIV care, but had not undergone routine screening for breast, cervical, or colonic neoplasia. She presented with a left groin mass, which on biopsy proved to be a p16 immuno-histochemical positive squamous cell carcinoma. Anal and cervicovaginal examinations did not show invasive cancer, although high-resolution anoscopy identified high-grade anal dysplasia...
May 2016: Journal of the International Association of Providers of AIDS Care
Ira L Leeds, Sandy H Fang
This review focuses on the early diagnosis of anal cancer and its precursor lesions through routine screening. A number of risk-stratification strategies as well as screening techniques have been suggested, and currently little consensus exists among national societies. Much of the current clinical rationale for the prevention of anal cancer derives from the similar tumor biology of cervical cancer and the successful use of routine screening to identify cervical cancer and its precursors early in the disease process...
January 27, 2016: World Journal of Gastrointestinal Surgery
Alice M Schofield, Laura Sadler, Linsey Nelson, Matthew Gittins, Mina Desai, Alex Sargent, Raymond F T McMahon, James Hill, Emma J Crosbie, Julietta Patnick, Henry C Kitchener
OBJECTIVE: The study sought to establish the feasibility and acceptability of anal screening among men MSM. DESIGN: Prospective cohort study. SETTING: Sexual health clinics in tertiary care. PATIENTS: Known HIV-positive and negative MSM who have anoreceptive intercourse. INTERVENTION: Anal screening with human papilloma virus (HPV) testing, liquid-based cytology and high-resolution anoscopy with biopsy of anoscopic abnormalities...
June 1, 2016: AIDS
W Fuchs, U Wieland, A Skaletz-Rorowski, N H Brockmeyer, J Swoboda, A Kreuter, C Michalik, A Potthoff
BACKGROUND: Human papillomaviruses (HPV) induce condylomata, anogenital cancers and their precursor lesions as anal or penile intraepithelial neoplasia (AIN/PIN). HIV-positive individuals have an increased risk for the development of anogenital HPV-induced lesions. OBJECTIVE: Estimation of the prevalence of HPV-related anogenital benign and malignant lesions in HIV-infected men attending a screening programme. METHODS: Four hundred HIV-positive men [98% men who have sex with men (MSM)] were enrolled in this prospective study from 2008 to 2011...
June 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
Richard J Hillman, Manoji P W Gunathilake, Fengyi Jin, Winnie Tong, Andrew Field, Andrew Carr
UNLABELLED: Background Anal cancer is increasing in incidence, has very high rates in specific populations and shares many similarities with cervical cancer. High-grade squamous intraepithelial lesions (HSIL) are regarded as precursors to anal cancer. High resolution anoscopy (HRA), which is derived from colposcopy, is the only currently available tool that can identify areas of the anal canal for targeted biopsy and identification of HSIL. METHODS: This study investigated the ability over a period of time of a single anoscopist to identify and adequately biopsy HSIL, correlating with contemporary anal cytological findings...
April 2016: Sexual Health
Garazi Elorza, Yolanda Saralegui, Jose María Enríquez-Navascués, Carlos Placer, Leyre Velaz
Anal intraepitelial neoplasia (AIN) constitutes a major health problem in certain risk groups, such as patients with immunosuppression of varied origin, males who have sexual relations with other males, and females with a previous history of vaginal or cervical abnormalities in cytology. Its relationship with the human papillomavirus (HPV) infection has been well documented; however, many of the factors involved in the progression and regression of the viral infection to dysplasia and anal carcinoma are unknown...
January 2016: Revista Española de Enfermedades Digestivas
Gypsyamber DʼSouza, Alicia Wentz, Dorothy Wiley, Nisha Shah, Francine Barrington, Teresa M Darragh, Nancy Joste, Michael Plankey, Susheel Reddy, Elizabeth C Breen, Stephen Young, Ross D Cranston
OBJECTIVE: To evaluate the prevalence of anal cytology (ACyt) abnormalities among HIV-infected and HIV-uninfected men who have sex with men (MSM). DESIGN: Multicenter cohort study of 723 HIV-infected and 788 HIV-uninfected MSM with ACyt, with a second ACyt collected 2 years later. A referral for high-resolution anoscopy was suggested for abnormal ACyt. METHODS: ACyt samples were collected using a polyester swab and liquid cytology media and read in a central laboratory...
April 15, 2016: Journal of Acquired Immune Deficiency Syndromes: JAIDS
Naomi Jay, J Michael Berry, Christine Miaskowski, Misha Cohen, Elizabeth Holly, Teresa M Darragh, Joel M Palefsky
No abstract text is available yet for this article.
December 2015: Papillomavirus Research
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