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Dyslipidaemia

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https://www.readbyqxmd.com/read/29772482/baseline-serum-sitosterol-level-as-predictor-of-adverse-clinical-events-in-acute-coronary-syndrome-patients-with-dyslipidaemia-a-sub-analysis-of-hij-proper
#1
Junichi Yamaguchi, Erisa Kawada-Watanabe, Ryo Koyanagi, Hiroyuki Arashi, Haruki Sekiguchi, Koichi Nakao, Tetsuya Tobaru, Hiroyuki Tanaka, Toshiaki Oka, Yasuhiro Endo, Katsumi Saito, Tatsuro Uchida, Kunihiko Matsui, Hiroshi Ogawa, Nobuhisa Hagiwara
BACKGROUND AND AIMS: We aimed to examine the effect of serum sitosterol, a cholesterol absorption marker, on clinical outcomes in acute coronary syndrome patients with dyslipidaemia. METHODS: This is a sub-analysis of the HIJ-PROPER trial that assesses the effect of aggressive low-density lipoprotein cholesterol (LDL-C) lowering treatment with pitavastatin + ezetimibe in 1734 acute coronary syndrome (ACS) patients with dyslipidaemia. Patients were divided into two groups based on sitosterol level at enrolment (cut-off value was 2...
May 5, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29770749/rosuvastatin-and-atorvastatin-preserve-renal-function-in-hiv-1-infected-patients-with-chronic-kidney-disease-and-hyperlipidaemia
#2
Leonardo Calza, Vincenzo Colangeli, Marco Borderi, Roberto Manfredi, Lorenzo Marconi, Isabella Bon, Maria Carla Re, Pierluigi Viale
BACKGROUND: Hyperlipidaemia is a risk factor for the progression of chronic kidney disease (CKD), which is a frequent comorbidity in patients with HIV-1 infection, but the renal effects of statins remain unclear. METHODS: We performed an observational, prospective study of HIV-infected patients on suppressive antiretroviral therapy, with CKD and hyperlipidaemia, and starting a lipid-lowering treatment with rosuvastatin, atorvastatin or omega-3 fatty acids. CKD was defined as an estimated glomerular filtration rate (eGFR) ≤ 60 mL/min/1...
June 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29770748/the-effect-of-switching-protease-inhibitors-to-raltegravir-on-endothelial-function-in-hiv-infected-patients
#3
Maaike Krikke, Kiki Tesselaar, Guido E L van den Berk, Sigrid A Otto, Laura H Freriks, Steven F L van Lelyveld, Frank J L Visseren, Andy I M Hoepelman, Joop E Arends
Objective Lipid management is one of the cornerstones of cardiovascular risk reduction. Treatment of HIV infection with protease inhibitors (PIs) may cause dyslipidaemia, whilst the integrase inhibitor raltegravir (RAL) has a relatively favorable effect on plasma lipids. We examined the effect of switching from PIs to RAL on endothelial function, and its effect on immunological and inflammatory parameters. Methods We performed a 16-week open-label prospective crossover study: 8 weeks intervention (switch PIs to RAL) and 8 weeks control (unchanged cART regimen)...
April 2018: HIV Clinical Trials
https://www.readbyqxmd.com/read/29764874/resuming-anticoagulants-after-anticoagulation-associated-intracranial-haemorrhage-systematic-review-and-meta-analysis
#4
Zien Zhou, Jie Yu, Cheryl Carcel, Candice Delcourt, Jiehui Shan, Richard I Lindley, Bruce Neal, Craig S Anderson, Maree L Hackett
OBJECTIVE: To determine the adverse outcomes following resumption of anticoagulation in patients with anticoagulation-associated intracranial haemorrhage (ICH). DESIGN: We performed a systematic review and meta-analysis in this clinical population. The Preferred Reporting Items for Systemic Reviews and Meta-Analyses statement was followed, and two authors independently assessed eligibility of all retrieved studies and extracted data. DATA SOURCES: Medline, Embase and the Cochrane Central Register of Controlled Trials, from inception to February 2017...
May 14, 2018: BMJ Open
https://www.readbyqxmd.com/read/29761897/chronic-ethanol-exposure-of-human-pancreatic-normal-ductal-epithelial-cells-induces-cancer-stem-cell-phenotype-through-satb2
#5
Wei Yu, Yuming Ma, Sharmila Shankar, Rakesh K Srivastava
The incidence of pancreatic cancer is on the rise. Risk factors for pancreatic cancer include alcohol toxicity and metabolic conditions such as obesity, hypertension, dyslipidaemia, insulin resistance and type 2 diabetes. However, the molecular mechanism by which chronic alcohol consumption contributes to pancreatic cancer is not well understood. The purpose of the study was to demonstrate the effects of long-term chronic ethanol exposure on the transformation of human pancreatic normal ductal epithelial (HPNE) cells...
May 15, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29759006/interplay-between-hypercholesterolaemia-and-inflammation-in-atherosclerosis-translating-experimental-targets-into-clinical-practice
#6
José Tuñón, Magnus Bäck, Lina Badimón, Marie-Luce Bochaton-Piallat, Bertrand Cariou, Mat J Daemen, Jesus Egido, Paul C Evans, Sheila E Francis, Daniel Fj Ketelhuth, Esther Lutgens, Christian M Matter, Claudia Monaco, Sabine Steffens, Erik Stroes, Cécile Vindis, Christian Weber, Imo E Hoefer
Dyslipidaemia and inflammation are closely interconnected in their contribution to atherosclerosis. In fact, low-density lipoprotein (LDL)-lowering drugs have anti-inflammatory effects. The Canakinumab Antiinflammatory Thrombosis Outcome Study (CANTOS) has shown that interleukin (IL)-1β blockade reduces the incidence of cardiovascular events in patients with previous myocardial infarction and C-reactive protein levels >2 mg/L. These data confirm the connection between lipids and inflammation, as lipids activate the Nod-like receptor protein 3 inflammasome that leads to IL-1β activation...
January 1, 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29754571/reference-intervals-for-serum-lipids-and-prevalence-of-dyslipidaemia-in-6-12-year-old-children-the-health-oriented-pedagogical-project-hopp
#7
Martin Frank Strand, Per Morten Fredriksen, Ole Petter Hjelle, Morten Lindberg
AIMS: Elevated serum lipid concentrations in childhood are thought to be risk factors for the development of cardiovascular disease later in life. The present study aims to provide age- and gender-related reference intervals for total cholesterol (TC), high-density lipoprotein (HDL) cholesterol, and non-HDL cholesterol in healthy school children. We also investigated the prevalence of dyslipidaemia using the published criteria for these biomarkers. METHODS: Venous blood and anthropometric data were collected from 1340 children in the HOPP study, aged between 6 and 12 years...
May 2018: Scandinavian Journal of Public Health
https://www.readbyqxmd.com/read/29747663/the-lipid-lowering-effects-of-danhong-and-huangqi-injections-a-meta-analysis-of-clinical-controlled-trials
#8
Liuqin Yu, Chunyang Zhou, Zhi Luo, Wei Zeng, Feiya Lai, Gangjie Han, Yongyan Song
BACKGROUND: Dyslipidaemia is a major risk factor for coronary heart disease (CHD). Danhong and Huangqi injections, two traditional Chinese medicine prescriptions, have been widely studied regarding their lipid-lowering properties. However, the results were inconsistent and inconclusive. Thus, we conducted this meta-analysis of clinical controlled trials to clarify the lipid-lowering effects of Danhong and Huangqi injections. METHODS: The databases including PubMed, Google Scholar, Web of Science, Cochrane Library, Wanfang Database, CNKI and VIP were searched...
May 10, 2018: Lipids in Health and Disease
https://www.readbyqxmd.com/read/29737587/the-glycaemic-benefits-of-a-very-low-carbohydrate-ketogenic-diet-in-adults-with-type-1-diabetes-mellitus-may-be-opposed-by-increased-hypoglycaemia-risk-and-dyslipidaemia
#9
Z Z X Leow, K J Guelfi, E A Davis, T W Jones, P A Fournier
AIMS: To investigate whether very-low-carbohydrate high-fat diets, typical of ketogenic diets, can improve glycaemic control without causing any ill health effects in adults with Type 1 diabetes. METHODS: In this observational study, 11 adults with Type 1 diabetes (seven men, four women, mean ± sd age 36.1± 6.8 years, mean ± sd duration of diabetes 12.8 ± 10.3 years), who followed a ketogenic diet (< 55 g carbohydrate per day) for a mean ± sd of 2.6 ± 3...
May 8, 2018: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29729156/correlations-between-lipid-metabolism-indices-in-patients-with-hypertension-and-hypothyroidism
#10
Lyubov V Olenych, Lesya I Pylypiv, Nataliya S Bek, Olena M Radchenko
OBJECTIVE: Introduction: Hypertension is a major reason behind morbidity, disability and mortality. Elevated blood pressure is a huge risk factor for cardio-vascular diseases. Almost 90% of hypertension patients have internal comorbidities, in particular hypothyroidism. For now, however, the specificities of the clinical course of hypertension in hypothyroid patients are understudied and the data on lipid metabolism in patients with primary hypothyroidism and hypertension are inconclusive...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29729003/exercise-prescription-in-patients-with-different-combinations-of-cardiovascular-disease-risk-factors-a-consensus-statement-from-the-expert-working-group
#11
REVIEW
Dominique Hansen, Josef Niebauer, Veronique Cornelissen, Olga Barna, Daniel Neunhäuserer, Christoph Stettler, Cajsa Tonoli, Eugenio Greco, Robert Fagard, Karin Coninx, Luc Vanhees, Massimo F Piepoli, Roberto Pedretti, Gustavo Rovelo Ruiz, Ugo Corrà, Jean-Paul Schmid, Constantinos H Davos, Frank Edelmann, Ana Abreu, Bernhard Rauch, Marco Ambrosetti, Simona Sarzi Braga, Paul Beckers, Maurizio Bussotti, Pompilio Faggiano, Esteban Garcia-Porrero, Evangelia Kouidi, Michel Lamotte, Rona Reibis, Martijn A Spruit, Tim Takken, Carlo Vigorito, Heinz Völler, Patrick Doherty, Paul Dendale
Whereas exercise training is key in the management of patients with cardiovascular disease (CVD) risk (obesity, diabetes, dyslipidaemia, hypertension), clinicians experience difficulties in how to optimally prescribe exercise in patients with different CVD risk factors. Therefore, a consensus statement for state-of-the-art exercise prescription in patients with combinations of CVD risk factors as integrated into a digital training and decision support system (the EXercise Prescription in Everyday practice & Rehabilitative Training (EXPERT) tool) needed to be established...
May 4, 2018: Sports Medicine
https://www.readbyqxmd.com/read/29724488/factors-contributing-to-disability-in-rheumatoid-arthritis-patients-an-egyptian-multicenter-study
#12
Marwa Hammad, Mervat Eissa, Ghada A Dawa
OBJECTIVE: Minimizing disability and enhancing physical function to its optimal levels is still a challenge in management of rheumatoid arthritis (RA). The aim is to identify factors leading to disability in RA. METHODS: This is a cross-sectional Egyptian multicenter study carried out on 215 RA patients attending to our inpatient and outpatient rheumatology clinics during 4 months starting from April to July 2017 who agreed to participate in the study; 170 patients were from Cairo University hospitals and 45 from Zagazig University hospitals...
April 30, 2018: Reumatología Clinica
https://www.readbyqxmd.com/read/29720336/hypothyroidism-affects-lipid-and-glycogen-content-and-peroxisome-proliferator-activated-receptor-expression-in-the-ovary-of-the-rabbit
#13
Julia Rodríguez-Castelán, Maribel Méndez-Tepepa, Jorge Rodríguez-Antolín, Francisco Castelán, Estela Cuevas-Romero
Dyslipidaemia and hyperglycaemia are associated with ovarian failure and both have been related to hypothyroidism. Hypothyroidism promotes anovulation and ovarian cysts in women and reduces the size of follicles and the expression of aromatase in the ovary of rabbits. Considering that ovarian steroidogenesis and ovulation depend on lipid metabolism and signalling, the aim of the present study was to analyse the effect of hypothyroidism on the lipid content and expression of peroxisome proliferator-activated receptor (PPAR) δ in the ovary...
May 3, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29713239/oxysterols-increase-inflammation-lipid-marker-levels-and-reflect-accelerated-endothelial-dysfunction-in-experimental-animals
#14
Tomasz Wielkoszyński, Jolanta Zalejska-Fiolka, Joanna K Strzelczyk, Aleksander J Owczarek, Armand Cholewka, Marcin Furmański, Agata Stanek
Objective: Oxidized cholesterol derivatives are thought to exert atherogenic effect thus adversely affecting vascular endothelium. The aim of the study was to assess the effect of 5 α ,6 α -epoxycholesterol on experimentally induced hypercholesterolemia in rabbits, and the levels of homocysteine (HCY), asymmetric dimethylarginine (ADMA), paraoxonase-1 (PON-1), and inflammatory parameters (IL-6, TNF- α , CRP). Material and methods: The rabbits were divided into 3 groups, 8 animals each, and fed with basic fodder (C), basic fodder plus cholesterol (Ch) or basic fodder plus 5 α ,6 α -epoxycholesterol, and unoxidized cholesterol (ECh)...
2018: Mediators of Inflammation
https://www.readbyqxmd.com/read/29712720/metabolic-disorders-during-pregnancy-and-postpartum-cardiometabolic-risk
#15
Angelo Maria Patti, Kalliopi Pafili, Nikolaos Papanas, Manfredi Rizzo
Hormonal changes during pregnancy can trigger gestational diabetes (GDM), which is constantly increasing. Its main characteristic is pronounced insulin resistance, but it appears to be a multifactorial process involving several metabolic factors; taken together, the latter lead to silent or clinically evident cardiovascular (CV) events. Insulin resistance and central adiposity are of crucial importance in the development of metabolic syndrome and they appear to correlate with CV risk factors, including hypertension and atherogenic dyslipidaemia...
April 30, 2018: Endocrine Connections
https://www.readbyqxmd.com/read/29703872/prevalence-risk-factors-and-secondary-prevention-of-stroke-recurrence-in-eight-countries-from-south-east-and-southeast-asia-a-scoping-review
#16
Y Y Chin, H Sakinah, A Aryati, B M Hassan
INTRODUCTION: In most Asian countries, stroke is one of the major causes of mortality. A stroke event is life-changing for stroke survivors, which results in either mortality or disability. Therefore, this study comprehensively focuses on prevalence, risk factors, and secondary prevention for stroke recurrence identified in South, East, and Southeast Asian countries. METHODS: This scoping review uses the methodological framework of Arksey and O'Malley. A comprehensive search of academic journals (English) on this topic published from 2007 to 2017 was conducted...
April 2018: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29701394/ascending-aorta-aneyrysms-over-70mm
#17
Jorge Pinheiro Santos, Álvaro Laranjeira, António Cruz Tomás, Daniela Varela-Afonso, José Fragata
INTRODUCTION: Current guidelines suggest that patients with aortic diameter over 55-60 mm should undergo ascending aorta replacement, depending on associated valve pathology and other comorbidities. Studies show that the risk of aortic rupture over 60 mm is over 30%. Even though, we still receive in our practice patients that present with aneurysms of greater dimensions. The aim of our study is to evaluate the surgical outcomes of patients presenting with ascending aorta with diameter larger than 70 mm...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701390/ascending-aorta-aneurysms-in-octogenarians
#18
Jorge Pinheiro Santos, Álvaro Laranjeira, António Cruz Tomás, Daniela Varela-Afonso, José Fragata
INTRODUCTION: Older age is often regarded as a relative contraindication for open surgery for aortic aneurysms. These individuals often have a greater comorbidity burden that predispose them for development of postoperative complications. The aim of our study is to evaluate the surgical outcomes of selected octogenarians after open aortic surgery. METHODS: We performed a retrospective observational study. We collected data from patients operated on by our team between January of 2012 to September of 2017...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29699712/foetoplacental-epigenetic-changes-associated-with-maternal-metabolic-dysfunction
#19
Bredford Kerr, Andrea Leiva, Marcelo Farías, Susana Contreras-Duarte, Fernando Toledo, Francisca Stolzenbach, Luis Silva, Luis Sobrevia
Metabolic-related diseases are attributed to a sedentary lifestyle and eating habits, and there is now an increased awareness regarding pregnancy as a preponderant window in the programming of adulthood health and disease. The developing foetus is susceptible to the maternal environment; hence, any unfavourable condition will result in foetal physiological adaptations that could have a permanent impact on its health. Some of these alterations are maintained via epigenetic modifications capable of modifying gene expression in metabolism-related genes...
April 12, 2018: Placenta
https://www.readbyqxmd.com/read/29688324/determinants-of-long-term-clinical-outcomes-in-patients-with-angina-but-without-obstructive-coronary-artery-disease-a-systematic-review-and-meta-analysis
#20
Francesco Radico, Marco Zimarino, Fabio Fulgenzi, Fabrizio Ricci, Marta Di Nicola, Lasse Jespersen, Su Min Chang, Karin H Humphries, Mario Marzilli, Raffaele De Caterina
Aims: The long-term prognosis of angina in patients without obstructive coronary artery disease (CAD) is uncertain. To assess the incidence of long-term adverse outcomes in such patients. Methods and results: We searched PubMed, Cochrane Library, the Embase database, and the Clinical Trials Registry for studies published in English until January 2017, assessing the composite primary outcome of all-cause death and non-fatal myocardial infarction using random-effects models to estimate pooled incidences...
April 23, 2018: European Heart Journal
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