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https://www.readbyqxmd.com/read/28086954/a-comparative-analysis-between-sequential-boost-and-integrated-boost-intensity-modulated-radiation-therapy-with-concurrent-chemotherapy-for-locally-advanced-head-and-neck-cancer
#1
Gregory Vlacich, Mark J Stavas, Praveen Pendyala, Shaeu-Chiann Chen, Yu Shyr, Anthony J Cmelak
BACKGROUND: Planning and delivery of IMRT for locally advanced head and neck cancer (LAHNC) can be performed using sequential boost or simultaneous integrated boost (SIB). Whether these techniques differ in treatment-related outcomes including survival and acute and late toxicities remain largely unexplored. METHODS: We performed a single institutional retrospective matched cohort analysis on patients with LAHNC treated with definitive chemoradiotherapy to 69.3 Gy in 33 fractions...
January 13, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/28077159/concurrent-chemoradiotherapy-combined-with-enteral-nutrition-support-a-radical-treatment-strategy-for-esophageal-squamous-cell-carcinoma-patients-with-malignant-fistulae
#2
Li Ma, Guang-Yu Luo, Yu-Feng Ren, Bo Qiu, Hong Yang, Chun-Xia Xie, Song-Ran Liu, Shi-Liang Liu, Zhao-Lin Chen, Qun Li, Jian-Hua Fu, Meng-Zhong Liu, Yong-Hong Hu, Wen-Feng Ye, Hui Liu
BACKGROUND: Concurrent chemoradiotherapy (CCRT) significantly increases the survival rate of esophageal squamous cell carcinoma (ESCC) patients with malignant fistulae. Recent clinical evidence has shown the benefits of enteral nutrition for malnourished cancer patients. In this study, we aimed to validate that, with the support of enteral nutrition, ESCC patients who develop malignant fistulae might be able to complete CCRT and achieve long-term survival. METHODS: We reviewed the medical records of 652 patients with ESCC who received definitive CCRT at Sun Yat-sen University Cancer Center between January 2010 and December 2012...
January 11, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28046941/su-g-iep3-13-real-time-patient-and-staff-dose-monitoring-in-fluoroscopy-guided-interventions
#3
L Vergoossen, A Sailer, L Paulis, J Wildberger, C Jeukens
PURPOSE: Interventional radiology procedures involve the use of X-rays, which can pose a large radiation burden on both patients and staff. Although some reports on radiation dose are available, most studies focus on limited types of procedures and only report patient dose. In our cathlabs a dedicated real-time patient and staff monitoring system was installed in November 2015. The aim of this study was to investigate the patient and staff dose exposure for different types of interventions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28040717/predictors-of-the-use-of-specific-critical-care-therapies-in-patients-with-metastatic-cancer
#4
Kah Poh Loh, Ankit Kansagra, Meng-Shiou Shieh, Penelope Pekow, Peter Lindenauer, Mihaela Stefan, Tara Lagu
OBJECTIVE: Understanding which factors are associated with the use of critical care therapies (CCTs) can help with clinical decision-making and goals of care discussion. The goal of this study was to describe the predictors of CCT use (eg, mechanical ventilation, tracheostomy, percutaneous endoscopic gastrostomy tube, total parenteral nutrition, acute use of dialysis) in hospitalized patients with metastatic cancer. METHODS: We used the 2010 California State Inpatient Databases sponsored by the Agency for Healthcare Research and Quality to identify all hospitalizations with a diagnosis of metastatic cancer (patients aged ≥18 years)...
January 2017: Journal of the National Comprehensive Cancer Network: JNCCN
https://www.readbyqxmd.com/read/28039644/incidence-of-abdominal-wall-metastases-following-percutaneous-endoscopic-gastrostomy-placement-in-patients-with-head-and-neck-cancer
#5
Eleanor Fung, David S Strosberg, Edward L Jones, Rebecca Dettorre, Andrew Suzo, Michael P Meara, Vimal K Narula, Jeffrey W Hazey
INTRODUCTION: Percutaneous endoscopic gastrostomy (PEG) tubes are an effective modality for enteral nutrition in patients with head and neck cancer; however, there have been documented case reports of "seeding" of the abdominal wall by the theoretic risk of dragging the tube along the tumor during PEG placement. The objective of this study is to determine the incidence and contributing risk factors leading to metastasis to the abdominal wall following PEG placement in patients with head and neck cancer...
December 30, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/28039511/increased-morbidity-and-mortality-in-cardiac-patients-undergoing-fundoplication
#6
Heather L Short, Curtis Travers, Courtney McCracken, Mark L Wulkan, Matthew S Clifton, Mehul V Raval
BACKGROUND: Infants with congenital cardiac disease (CCD) often require gastrostomy tube placement (GT) and need antireflux procedures, such as fundoplications. Our purpose was to compare morbidity/mortality rates among infants with CCD undergoing GT, fundoplication, or both. METHODS: Using the NSQIP-Pediatric, we identified 4070 patients <1-year-old who underwent GT and/or fundoplication from 2012 to 2014. 2346 infants (58%) had CCD categorized as minor, major or severe...
December 30, 2016: Pediatric Surgery International
https://www.readbyqxmd.com/read/28027240/gastrostomy-placement-rates-in-infants-with-pierre-robin-sequence-a-comparison-of-tongue-lip-adhesion-and-mandibular-distraction-osteogenesis
#7
Srinivas M Susarla, Gerhard S Mundinger, Christopher C Chang, Edward W Swanson, Denver Lough, S Alex Rottgers, Richard J Redett, Anand R Kumar
BACKGROUND: This study was conducted to compare the gastrostomy rates in infants with Pierre Robin sequence treated with tongue-lip adhesion or mandibular distraction osteogenesis. METHODS: This was a retrospective study of symptomatic plastic and reconstructive surgery patients treated over an 8-year period. The primary predictor variable was surgical intervention (tongue-lip adhesion or distraction osteogenesis). Secondary predictor variables were categorized as demographic and clinical factors...
January 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28012691/multicentre-survey-on-the-current-surgical-management-of-oesophageal-atresia-in-belgium-and-luxembourg
#8
Helena Reusens, Lucas Matthyssens, Charlotte Vercauteren, Katrien van Renterghem
INTRODUCTION: The surgical management of oesophageal atresia (OA) differs between pediatric surgical teams without consensus. We aimed to describe the current practice of OA treatment in Belgium and Luxembourg and compare this to the literature. MATERIALS AND METHODS: A questionnaire was created and sent to all 18 hospitals (14 pediatric surgical units) performing OA surgery in Belgium and Luxembourg. The results were compared to the literature. RESULTS: Most units treat an average of 2-5 OA+TOF (71%) and ≤1 pure OA (pOA) per year (86%)...
November 14, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28009454/direct-estimation-for-adaptive-treatment-length-policies-methods-and-application-to-evaluating-the-effect-of-delayed-peg-insertion
#9
Xin Lu, Brent A Johnson
Dysphagia is a primary cause of death among patients diagnosed with amyotrophic lateral sclerosis (ALS), and percutaneous endoscopic gastrostomy (PEG) is a procedure to insert a tube into the stomach to assist or replace oral feeding. It is believed that PEG is beneficial and, generally, earlier insertion is preferable to later. However, gathering clinical evidence to support these beliefs on the use and timing of PEG is challenging because controlled clinical trials are not feasible and clinical endpoints are confounded with PEG in observational data...
December 23, 2016: Biometrics
https://www.readbyqxmd.com/read/28008626/outcomes-of-surgically-treated-human-papillomavirus-related-oropharyngeal-squamous-cell-carcinoma-with-n3-disease
#10
Joseph Zenga, Bruce H Haughey, Ryan S Jackson, Douglas R Adkins, John Aranake-Chrisinger, Neel Bhatt, Hiram A Gay, Dorina Kallogjeri, Eliot J Martin, Eric J Moore, Randal C Paniello, Jason T Rich, Wade L Thorstad, Brian Nussenbaum
OBJECTIVES/HYPOTHESIS: To evaluate outcomes for patients with pathological N3 (pN3) neck disease from human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (OPSCC) and determine variables predictive of survival. STUDY DESIGN: Retrospective case series with chart review. METHODS: This study was conducted between 1998 and 2013 and included patients with HPV-related OPSCC treated with surgery with or without adjuvant therapy and who had pN3 nodal disease...
December 23, 2016: Laryngoscope
https://www.readbyqxmd.com/read/27990013/intraoperative-gastric-intramural-hematoma-a-rare-complication-of-percutaneous-endoscopic-gastrostomy
#11
Chi Chan Lee, Sharmila Ravindranathan, Vivek Choksi, Jestin Pudussery Kattalan, Uday Shankar, Steven Kaplan
BACKGROUND Intramural hematomas primarily present in the esophagus or duodenum. We report a case of intramural hematoma in the gastric wall (GIH) secondary to percutaneous endoscopic gastrostomy (PEG) tube placement in a setting of platelet dysfunction. CASE REPORT This case study reviews the hospitalization of a 73-year-old male with a history of chronic kidney disease who was admitted for coronary artery bypass graft surgery and mitral valve repair. During his complicated hospital course, he inadvertently required the placement of a PEG tube...
December 19, 2016: American Journal of Case Reports
https://www.readbyqxmd.com/read/27986517/comparison-of-nutritional-and-clinical-outcomes-in-patients-with-head-and-neck-cancer-undergoing-chemoradiotherapy-utilizing-prophylactic-versus-reactive-nutrition-support-approaches
#12
Teresa E Brown, Merrilyn D Banks, Brett G M Hughes, Charles Y Lin, Lizbeth M Kenny, Judith D Bauer
BACKGROUND: The optimal method of tube feeding for patients with head and neck cancer remains unclear. A validated protocol is available that identifies high-nutritional-risk patients who would benefit from prophylactic gastrostomy tube placement. Adherence to this protocol is ultimately determined by clinical team discretion or patient decision. OBJECTIVE: The study aim was to compare outcomes after adherence and nonadherence to this validated protocol, thus comparing a prophylactic and reactive approach to nutrition support in this patient population...
December 13, 2016: Journal of the Academy of Nutrition and Dietetics
https://www.readbyqxmd.com/read/27979610/salivary-bypass-tube-placement-in-esophageal-stricture-a-technical-note-and-report-of-three-cases
#13
Giancarlo Tirelli, Roberto Baruca, Francesca Boscolo Nata
Hypopharyngeal and cervical esophageal strictures can be caused by advanced malignancies, ingestion of caustic materials, or can follow surgery or radiation therapy. They cause marked dysphagia and consequently patients need nasogastric or gastrostomy tube feeding, with a remarkable impact on quality of life. To restore oral feeding, the stenosis can be progressively dilated by using rubber bougies of increasing diameter, and a Montgomery(®) Salivary Bypass Tube can then be inserted to maintain the obtained calibre...
December 12, 2016: Auris, Nasus, Larynx
https://www.readbyqxmd.com/read/27965848/a-feasibility-study-incorporating-a-pilot-randomised-controlled-trial-of-oral-feeding-plus-pre-treatment-gastrostomy-tube-versus-oral-feeding-plus-as-needed-nasogastric-tube-feeding-in-patients-undergoing-chemoradiation-for-head-and-neck-cancer-tube-trial-study
#14
Vinidh Paleri, Joshua Wood, Joanne Patterson, Deborah D Stocken, Mike Cole, Luke Vale, Jeremy Franks, Teresa Guerrero-Urbano, Rachael Donnelly, Stewart Barclay, Tim Rapley, Nikki Rousseau
BACKGROUND: There are 7000 new cases of head and neck squamous cell cancers (HNSCC) treated by the NHS each year. Stage III and IV HNSCC can be treated non-surgically by radio therapy (RT) or chemoradiation therapy (CRT). CRT can affect eating and drinking through a range of side effects with 90 % of patients undergoing this treatment requiring nutritional support via gastrostomy (G) or nasogastric (NG) tube feeding. Long-term dysphagia following CRT is a primary concern for patients...
2016: Pilot and Feasibility Studies
https://www.readbyqxmd.com/read/27965711/the-buried-bumper-syndrome-external-bumper-extraction-after-radial-mini-incisions-and-replacement-through-an-adjacent-tract
#15
M A Benatta
Although considered as a safe method to provide long-term nutritional support, percutaneous endoscopic gastrostomy (PEG) may be complicated by a buried bumper syndrome (BBS), a life-threatening condition. Removal of the PEG tube with its buried bumper and reinsertion of a new PEG tube is often necessary. Since its description in 1988, less than 50 cases of BBS managed by external extraction of the buried bumper have been reported. We report a case of buried bumper that was removed by external traction without the need for endoscopic or laparoscopic treatment but with the need of two radial millimeter skin incisions after abdominal CT study and finally immediate PEG replacement but through an adjacent site...
2016: Case Reports in Medicine
https://www.readbyqxmd.com/read/27965430/timing-of-percutaneous-endoscopic-gastrostomy-for-acute-ischemic-stroke-an-observational-study-from-the-us-nationwide-inpatient-sample
#16
Benjamin P George, Adam G Kelly, George P Albert, David Y Hwang, Robert G Holloway
BACKGROUND AND PURPOSE: Stroke guidelines recommend time-limited trials of nasogastric feeding prior to percutaneous endoscopic gastrostomy (PEG) tube placement. We sought to describe timing of PEG placement and identify factors associated with early PEG for acute ischemic stroke. METHODS: We designed a retrospective observational study to examine time to PEG for ischemic stroke admissions in the Nationwide Inpatient Sample, 2001 to 2011. We defined early PEG placement as 1 to 7 days from admission...
December 13, 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27939123/feeding-methods-at-discharge-predict-long-term-feeding-and-neurodevelopmental-outcomes-in-preterm-infants-referred-for-gastrostomy-evaluation
#17
Sudarshan R Jadcherla, Tanvi Khot, Rebecca Moore, Manish Malkar, Ish K Gulati, Jonathan L Slaughter
OBJECTIVE: To test the hypothesis that oral feeding at first neonatal intensive care unit discharge is associated with less neurodevelopmental impairment and better feeding milestones compared with discharge with a gastrostomy tube (G-tube). STUDY DESIGN: We studied outcomes for a retrospective cohort of 194 neonates <37 weeks' gestation referred for evaluation and management of feeding difficulties between July 2006 and July 2012. Discharge milestones, length of hospitalization, and Bayley Scales of Infant Development-Third Edition scores at 18-24 months were examined...
December 1, 2016: Journal of Pediatrics
https://www.readbyqxmd.com/read/27931635/complications-of-percutaneous-endoscopic-gastrostomy
#18
REVIEW
Tomas Hucl, Julius Spicak
Percutaneous endoscopic gastrostomy (PEG) has become the method of choice for mid-to long-term enteral feeding. The majority of complications that occur are minor, but the rare major complications may be life threatening. Some complications occur soon after tube placement, others develop later, when the gastrostomy tract has matured. Older patients with comorbidities and infections appear to be at a greater risk of developing complications. Apart from being aware of indications and contraindications, proper technique of PEG placement, including correct positioning of the external fixation device, and daily tube care are important preventive measures...
October 2016: Best Practice & Research. Clinical Gastroenterology
https://www.readbyqxmd.com/read/27930732/adjuvant-radiation-therapy-alone-for-hpv-related-oropharyngeal-cancers-with-high-risk-features
#19
William Su, Jerry Liu, Brett A Miles, Eric M Genden, Krzysztof J Misiukiewicz, Marshall Posner, Vishal Gupta, Richard L Bakst
BACKGROUND: Current standard of care for oropharyngeal cancers with positive surgical margins and/or extracapsular extension is adjuvant chemoradiotherapy. It is unknown whether HPV+ oropharyngeal cancer benefits from this treatment intensification. OBJECTIVE: To investigate the outcomes of HPV+ patients treated with adjuvant radiotherapy alone when chemoradiotherapy was indicated based on high risk pathological features. They were compared with high risk HPV+ patients treated with adjuvant chemoradiotherapy...
2016: PloS One
https://www.readbyqxmd.com/read/27929572/what-does-stop-igan-tell-us-about-how-to-treat-iga-nephropathy
#20
S Piracha, J Gnanapragasam, S M Tariq
Bronchoesophageal fistulae are a rare complication of tuberculosis. Traditionally they are managed by either thoracotomy with resection and closure of the fistulous tract or by taking a more conservative approach of giving standard treatment for tuberculosis while ensuring nutritional support through a nasogastric tube. We report a young student with disseminated tuberculosis complicated by a bronchoesophageal fistula. He was managed conservatively with anti-tuberculous chemotherapy and nutrition administered through a percutaneous endoscopic gastrostomy tube...
June 2016: Journal of the Royal College of Physicians of Edinburgh
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