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https://www.readbyqxmd.com/read/29910546/comparision-of-analgesic-efficacy-of-tramadol-infusion-versus-tramadol-plus-ondansetron-infusion-in-medical-intensive-care-unit
#1
Surya Prakash Yarramalle, Kartik Munta, S Manimala Rao, Pradeep Marur Venkategowda, Sagar Sunka, Sai Kiran Dudam
Background: Tramadol, a preferred analgesic due to its less respiratory depression. It also has a central action that blocks the reuptake and enhances the release of serotonin at spinal antinociceptive pathways. Ondansetron, an antiemetic is a serotonin receptor antagonist. Due to the contradictory actions of the two drugs, co-administration of these drugs resulted in higher usage of tramadol. All these studies were done in the postoperative period. Aim: The aim of this study is to evaluate the analgesic efficacy of tramadol infusion versus tramadol plus ondansetron infusion in Medical Intensive Care Unit (ICU) patients...
May 2018: Indian Journal of Critical Care Medicine
https://www.readbyqxmd.com/read/29910055/arterioventricular-interaction-after-coarctation-repair
#2
Elles J Dijkema, Martijn G Slieker, Tim Leiner, Heynric B Grotenhuis
BACKGROUND: Hypertension is common in patients with coarctation of the aorta (CoA), even after successful repair. Increased aortic stiffness has been implicated in the pathology of CoA-associated hypertension. This study aimed to investigate aortic vascular function and its relationship with hypertension in well-repaired CoA-patients at long-term follow-up. Furthermore, we assessed the additive effect of hypertension to adverse arterioventricular coupling associated with increased aortic stiffness...
July 2018: American Heart Journal
https://www.readbyqxmd.com/read/29904286/utility-of-venous-blood-gases-in-severe-sepsis-and-septic-shock
#3
Heath D White, Alfredo Vazquez-Sandoval, Pedro F Quiroga, Juhee Song, Shirley F Jones, Alejandro C Arroliga
Acid-base status is frequently assessed in severe sepsis and septic shock. Venous blood gas sampling is proposed as a less-invasive modality but lacks evidence within this population. The objective of this study was to evaluate the correlation and agreement between arterial blood gas (ABG), peripheral venous blood gas (pVBG), and central venous blood gas (cVBG) in severe sepsis and septic shock. We conducted a prospective, observational cohort study in subjects admitted to the medical intensive care unit. Simultaneous blood gas samples, including ABG, pVBG, and cVBG, were analyzed for correlation and agreement...
July 2018: Proceedings of the Baylor University Medical Center
https://www.readbyqxmd.com/read/29900347/endothelial-microparticles-and-vascular-parameters-in-subjects-with-and-without-arterial-hypertension-and-coronary-artery-disease
#4
Roberto Sansone, Maximilian Baaken, Patrick Horn, Dominik Schuler, Ralf Westenfeld, Nicolas Amabile, Malte Kelm, Christian Heiss
Endothelial microparticles (EMPs) are markers of endothelial injury and activation. The role of EMPs in arterial hypertension is not well understood and EMPs are increased both in arterial hypertension and coronary artery disease (CAD). The data presented here show EMPs as defined by CD31+ /41- , CD62e+ , and CD144+ surface markers and vascular hemodynamic parameters including office and central blood pressure, heart rate, aortic augmentation index, pulse wave velocity, flow-mediated dilation, nitroglycerin-mediated dilation, brachial artery diameter, hyperemic wall shear stress, and laser Doppler perfusion of the cutaneous microcirculation of normotensives and hypertensives with and without CAD...
August 2018: Data in Brief
https://www.readbyqxmd.com/read/29898246/evaluation-of-pulse-pressure-variation-and-pleth-variability-index-to-predict-fluid-responsiveness-in-mechanically-ventilated-isoflurane-anesthetized-dogs
#5
Hiroki Sano, Joonbum Seo, Paul Wightman, Nick J Cave, Mike A Gieseg, Craig B Johnson, Paul Chambers
OBJECTIVE: To evaluate whether pulse pressure variation (PPV) and pleth variability index (PVI) are more accurate than central venous pressure (CVP) for predicting fluid responsiveness in mechanically ventilated isoflurane-anesthetized dogs after premedication with acepromazine. DESIGN: Prospective experimental trial. SETTING: University teaching hospital. ANIMALS: Twelve Harrier hound dogs. INTERVENTIONS: Each dog was anesthetized and had a fluid challenge performed...
June 13, 2018: Journal of Veterinary Emergency and Critical Care
https://www.readbyqxmd.com/read/29897299/carotid-bodies-and-the-integrated-cardiorespiratory-response-to-hypoxia
#6
Bruce G Lindsey, Sarah C Nuding, Lauren S Segers, Kendall F Morris
Advances in our understanding of brain mechanisms for the hypoxic ventilatory response, coordinated changes in blood pressure, and the long-term consequences of chronic intermittent hypoxia as in sleep apnea, such as hypertension and heart failure, are giving impetus to the search for therapies to "erase" dysfunctional memories distributed in the carotid bodies and central nervous system. We review current network models, open questions, sex differences, and implications for translational research...
July 1, 2018: Physiology
https://www.readbyqxmd.com/read/29897263/the-effects-of-long-acting-stimulant-and-nonstimulant-medications-in-children-and-adolescents-with-attention-deficit-hyperactivity-disorder-a-meta-analysis-of-randomized-controlled-trials
#7
Alberto José Cerrillo-Urbina, Antonio García-Hermoso, María Jesús Pardo-Guijarro, Mairena Sánchez-López, José Luis Santos-Gómez, Vicente Martínez-Vizcaíno
OBJECTIVE: The aim of this study was to assess the efficacy and safety of stimulant and nonstimulant medications in children and adolescents using as an outcome measure the Attention-Deficit/Hyperactivity Disorder Rating Scale-IV (ADHD-RS-IV), and to examine the effect of medications in different ADHD subtypes (i.e., inattention and hyperactivity/impulsivity). METHODS: MEDLINE, Scopus, EMBASE, EBSCO (E-journal, CINAHL and SportDiscus), PUBMED, and The Cochrane Central Register of Controlled Trials databases were searched...
June 13, 2018: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/29897100/controlled-hypotension-versus-normotensive-resuscitation-strategy-for-people-with-ruptured-abdominal-aortic-aneurysm
#8
REVIEW
Daniel H Moreno, Daniel G Cacione, Jose Cc Baptista-Silva
BACKGROUND: An abdominal aortic aneurysm (AAA) is the pathological enlargement of the aorta and can develop in both men and women. Progressive aneurysm enlargement can lead to rupture. The rupture of an AAA is frequently fatal and accounts for the death from haemorrhagic shock of at least 45 people per 100,000 population. The outcome of people with ruptured AAA varies among countries and healthcare systems, with mortality ranging from 53% to 90%. Definitive treatment for ruptured AAA includes open surgery or endovascular repair...
June 13, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29897053/listening-in-on-the-microbubble-crowd-advanced-acoustic-monitoring-for-improved-control-of-blood-brain-barrier-opening-with-focused-ultrasound
#9
EDITORIAL
Catherine M Gorick, Natasha D Sheybani, Colleen T Curley, Richard J Price
Non-invasive drug and gene delivery to the brain to treat central nervous system pathologies has long been inhibited by the blood-brain barrier. The activation of microbubbles with focused ultrasound has emerged as a promising non-invasive approach to circumvent this obstacle, by transiently disrupting the blood-brain barrier and permitting passage of systemically administered therapeutics into the tissue. Clinical trials are underway to evaluate the safety of this technique; however, concerns remain regarding the potential for the treatment to induce sterile inflammation or petechiae...
2018: Theranostics
https://www.readbyqxmd.com/read/29894856/the-response-of-peripheral-microcirculation-to-gravity-induced-changes
#10
Zehava Ovadia-Blechman, Ashley Gritzman, Maya Shuvi, Benjamin Gavish, Vered Aharonson, Neta Rabin
BACKGROUND: The peripheral microcirculation supplies fresh blood to the small blood vessels, providing oxygen and nutrients to the tissues, removing waste, and maintaining normal homeostatic conditions. The goal of this study was to characterize the response of the peripheral microcirculation, in terms of blood flow and tissue oxygenation variables, to gravity-induced changes. METHODS: The study included 20 healthy volunteers and the experiment involved monitoring central and peripheral variables with the right hand positioned at different heights...
June 5, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29892497/fatness-and-fluctuating-body-weight-effect-on-central-vasculature
#11
Zachary S Zeigler, Natasha Birchfield, Karen Moreno, Darith James, Pamela Swan
Weight Cycling (WC) is a prevalent behavior associated with adverse cardiovascular (CV) health. However, a 2010 review on the effects of WC and blood pressure (BP) determined that there was not enough evidence to draw definitive conclusions. Central BP is the principal predictor of CV risk compared to peripheral BP. The influence that WC may have specifically on central BP is unknown. Cross-sectional observation of self-reported history of WC on measures of CV health was undertaken. Seventy-five women completed a Weight and Lifestyle Inventory questionnaire, which is considered a reliable index of WC ( r  = 0...
2018: BioResearch Open Access
https://www.readbyqxmd.com/read/29891878/genetically-driven-adiposity-traits-increase-the-risk-of-coronary-artery-disease-independent-of-blood-pressure-dyslipidaemia-glycaemic-traits
#12
Wan-Qiang Lv, Xue Zhang, Kun Fan, Xin Xia, Qiang Zhang, Hui-Min Liu, Bu-Ying Jiang, Wei-Dong Zhang, Hong-Wen Deng
Adiposity has been associated with the risk of coronary artery disease (CAD) in observational studies, but their association may differ according to specific characteristics of studies. In Mendelian randomization (MR) analyses, genetic variants are used as instrumental variables (IVs) of exposures to examine causal effects to overcome confounding factors and reverse causation. We performed MR analyses for adiposity (n = 322,154) on risk of CAD (60,801 cases and 123,504 controls) based on the currently largest genome-wide association studies...
June 11, 2018: European Journal of Human Genetics: EJHG
https://www.readbyqxmd.com/read/29889821/postexercise-hemodynamic-responses-in-lean-and-obese-men
#13
Zachary S Zeigler, Pamela D Swan, Matthew P Buman, Farouk Mookadam, Glenn A Gaesser, Siddhartha S Angadi
PURPOSE: We assessed resting central/peripheral blood pressure (BP), postexercise BP and hemodynamic responses [stroke volume (SV), cardiac output (CO), systemic vascular resistance (SVR)] after acute exercise and 2 wk of aerobic training in lean and centrally obese men matched for BP. METHODS: Eight lean (body mass index (BMI) <25 kg/m; visceral fat = 279±224 cm) and eight centrally obese (BMI>30 kg/m; visceral fat = 1,471±374 cm) men performed 6 training sessions (3d/wk for 40 min at 65-70%HRmax)...
June 8, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29888569/-asl-based-observation-of-central-nervous-system-responses-to-acupuncture-analgesia-for-people-with-different-sensitivities
#14
Lin Ma, Xue-Zhi Li, Ni-Ni Fu, Xiao-Guang Yang, Xiao-Fang Xi, Fei Liu, Yi Ren
OBJECTIVE: To examine the effects of different sensitivities on the effectiveness of acupuncture analgesia by observing activation change characteristics of cerebral areas resulting from the influences of constitutions on analgesia effects and to discuss the response mechanism of central nervous system (CNS) to determine the factor of constitutions on acupuncture efficacy using cerebral functional magnetic resonance imaging arterial spin labeling (fMRI-ASL). METHODS: Participants with different sensitivities were assessed according to standard screening and grouped into two groups: insensitivity group ( n =24) and sensitivity group ( n =22)...
May 25, 2018: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/29888314/reduced-left-ventricular-dimension-and-function-following-early-life-stress-a-thrifty-phenotype-hypothesis-engendering-risk-for-mood-and-anxiety-disorders
#15
Jeremy D Coplan, Anna V Rozenboym, Sasha L Fulton, Venkatesh Panthangi, Jean Tang, Lakshmi Thiramangalakdi, Tarique D Perera, Yang Liu, Haroon Kamran, Michael J Owens, Charles B Nemeroff, Leonard A Rosenblum, John G Kral, Louis Salciccioli, Jason Lazar
Background: Early life stress (ELS) in macaques in the form of insecure maternal attachment putatively induces epigenetic adaptations resulting in a "thrifty phenotype" throughout the life cycle. For instance, ELS induces persistent increases in insulin resistance, hippocampal and corpus callosum atrophy and reduced "behavioral plasticity", which, taken together, engenders an increased risk for mood and anxiety disorders in humans but also a putative sparing of calories...
February 2018: Neurobiology of Stress
https://www.readbyqxmd.com/read/29886609/-pulmonary-hypertensive-crisis-in-children-with-idiopathic-pulmonary-arterial-hypertension-undergoing-cardiac-catheterization-the-risk-factors-and-clinical-aspects
#16
C Zhang, Y Zhu, Q Q Li, H Gu
Objective: To investigate the risk factors, clinical features, treatments, and prevention of pulmonary hypertensive crisis (PHC) in children with idiopathic pulmonary arterial hypertension (IPAH) undergoing cardiac catheterization. Methods: This retrospective study included 67 children who were diagnosed with IPAH and underwent cardiac catheterization between April 2009 and June 2017 in Beijing Anzhen Hospital. The medical histories, clinical manifestations, treatments, and outcomes were characterized. Statistical analyses were performed using t test, χ(2) test and a multiple Logistic regression analysis...
June 2, 2018: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29886482/differential-stiffening-between-the-abdominal-and-thoracic-aorta-effect-of-salt-loading-in-stroke-prone-hypertensive-rats
#17
George Lindesay, Yvonnick Bézie, Christophe Ragonnet, Véronique Duchatelle, Chandima Dharmasena, Nicole Villeneuve, Christine Vayssettes-Courchay
Central artery stiffening is recognized as a cardiovascular risk. The effects of hypertension and aging have been shown in human and animal models but the effect of salt is still controversial. We studied the effect of a high-salt diet on aortic stiffness in salt-sensitive spontaneously hypersensitive stroke-prone rats (SHRSP). Distensibility, distension, and β-stiffness were measured at thoracic and abdominal aortic sites in the same rats, using echotracking recording of the aortic diameter coupled with blood pressure (BP), in SHRSP-salt (5% salted diet, 5 weeks), SHRSP, and normotensive Wistar-Kyoto (WKY) rats...
June 8, 2018: Journal of Vascular Research
https://www.readbyqxmd.com/read/29886438/associations-between-anthropometric-indices-blood-pressure-and-physical-fitness-performance-in-young-swiss-men-a-cross-sectional-study
#18
Kaspar Staub, Joël Floris, Nikola Koepke, Adrian Trapp, Andreas Nacht, Susanna Schärli Maurer, Frank J Rühli, Nicole Bender
OBJECTIVES: To assess the benefit of waist circumference (WC) measurements during routine conscription medical examination in two military conscription centres in Switzerland. We compared the prevalence of overweight and obesity assessed by body mass index (BMI) with the prevalence of elevated disease risks assessed by WC and waist-to-height ratio (WHtR). We investigated how these measures were associated with systolic blood pressure, physical fitness performance and socioeconomic determinants...
June 9, 2018: BMJ Open
https://www.readbyqxmd.com/read/29884912/sex-specific-contributions-of-endothelin-to-hypertension
#19
REVIEW
Eman Y Gohar, David M Pollock
PURPOSE OF REVIEW: Men and women differ in the prevalence, pathophysiology and control rate of hypertension in an age-dependent manner. The renal endothelin system plays a central role in sex differences in blood pressure regulation by control of sodium excretion and vascular function. Improving our understanding of the sex differences in the endothelin system, especially in regard to blood pressure regulation and sodium homeostasis, will fill a significant gap in our knowledge and may identify sex-specific therapeutic targets for management of hypertension...
June 8, 2018: Current Hypertension Reports
https://www.readbyqxmd.com/read/29883621/association-of-cardiorespiratory-fitness-with-retinal-vessel-diameters-as-a-biomarker-of-cardiovascular-risk
#20
Gioia Braun, Benjamin Hafner, Karsten Königstein, Denis Infanger, Christopher Klenk, Anja Rossmeissl, Arno Schmidt-Trucksäss, Henner Hanssen
OBJECTIVE: We aimed to investigate the association of retinal microvascular health with cardiorespiratory fitness (VO2 peak) and cardiovascular risk factors. METHODS: In a population of 260 obesity-enriched participants we investigated the association of retinal vessel diameters with cardiorespiratory fitness (CRF), body mass index (BMI) and blood pressure (BP). Retinal vessel imaging was performed by use of a fundus camera and a semi-automated processing software, calculating the central retinal arteriolar (CRAE) and venular equivalent (CRVE) as well as the arteriolar-to-venular diameter ratio (AVR)...
June 5, 2018: Microvascular Research
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