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Dental Biomaterials

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https://www.readbyqxmd.com/read/29343729/drug-self-assembly-for-synthesis-of-highly-loaded-antimicrobial-drug-silica-particles
#1
Cameron A Stewart, Yoav Finer, Benjamin D Hatton
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control...
January 17, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29331224/centrifugal-partition-chromatography-enables-selective-enrichment-of-trimeric-and-tetrameric-proanthocyanidins-for-biomaterial-development
#2
Rasika S Phansalkar, Joo-Won Nam, Shao-Nong Chen, James B McAlpine, Ariene A Leme, Berdan Aydin, Ana-Karina Bedran-Russo, Guido F Pauli
Proanthocyanidins (PACs) find wide applications for human use including food, cosmetics, dietary supplements, and pharmaceuticals. The chemical complexity associated with PACs has triggered the development of various chromatographic techniques, with countercurrent separation (CCS) gaining in popularity. This study applied the recently developed DESIGNER (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources) approach for the selective enrichment of trimeric and tetrameric PACs using centrifugal partition chromatography (CPC)...
December 21, 2017: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29316874/liposomal-delivery-of-demineralised-dentine-matrix-for-dental-tissue-regeneration
#3
Genevieve Elizabeth Melling, John Colombo, Steven J Avery, Wayne Ayre, Samuel L Evans, Rachel Jane Waddington, Alastair James Sloan
Current dental restorations have short longevity, consequently there is a need for novel tissue engineering strategies that aim to regenerate the dentine-pulp complex. Dentine matrix contains a myriad of bioactive growth factors and extracellular matrix proteins associated with the recruitment, proliferation and differentiation of dental pulp progenitor cells. Here, we show that demineralised dentine matrix (DDM), from non-carious dentine, can be encapsulated into liposomes for delivery to dental tissue to promote regeneration...
January 9, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29306530/evaluation-of-biocompatibility-and-osteogenic-potential-of-tricalcium-silicate-based-cements-using-human-bone-marrow-derived-mesenchymal-stem-cells
#4
Neha Sultana, Manisha Singh, Ruchika Roongta Nawal, Sarika Chaudhry, Seema Yadav, Sujata Mohanty, Sangeeta Talwar
INTRODUCTION: The success of endodontic regeneration lies in the appropriate combination of stem cells and bioactive materials. Several novel dental materials are available on the market in this regard. Hence, the current study aimed to evaluate the proliferation, differentiation, and osteogenic potential of human bone marrow-derived mesenchymal stem cells (hBMSCs) onto biomaterials like ProRoot MTA (MTA; Dentsply Tulsa Dental, Tulsa, OK), Biodentine (BD; Septodont, Saint Maur de Fosses, France), and EndoSequence Root Repair Material (ERRM; Brasseler USA, Savannah, GA)...
January 3, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29303409/clinical-evaluation-of-a-new-synthetic-resorbable-dental-membrane-a-case-series-study
#5
Hélène Martin Thomé, David Bourdin, Nicolas Strube, Afchine Saffarzadeh, Jean-Francois Morlock, Guillaume Campard, Charles Evanno, Alain Hoornaert, Pierre Layrolle
For the regeneration of small osseous defects, dental membranes are commonly used in oral and maxillofacial surgery. A new synthetic resorbable membrane has recently demonstrated its biocompatibility and bone regeneration capacity in preclinical studies. This membrane is made of poly-D,L-lactic/glycolic acid 85/15 (PLGA), has a bi-layered structure with a dense film to prevent gingival epithelial cell invasion and a micro-fibrous layer to support osteogenic cells and bone healing. This membrane completely degrades by hydrolysis in 4 to 6 months without signs of inflammation...
January 5, 2018: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29279770/dental-biomaterials-for-chairside-cad-cam-state-of-the-art
#6
REVIEW
Hugo Lambert, Jean-Cédric Durand, Bruno Jacquot, Michel Fages
The wide use of chairside CAD/CAM restorations has increased the diversity of the restorative material. For the practitioner, the selection of the appropriate material is difficult amongst the variety offered by the market. Information on the characteristics of the products can be difficult to assess due to the lack of up-to-date classification and the lack of reliability of manufacturer's advertising. The purpose of this article is to structure the data on restorative materials provided by various sources in order for the practitioner to choose the product most suited to the clinical situation...
December 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29274638/bone-regeneration-using-composite-non-demineralized-xenogenic-dentin-with-beta-tricalcium-phosphate-in-experimental-alveolar-cleft-repair-in-a-rabbit-model
#7
Mohammad Kamal, Lars Andersson, Rene Tolba, Adel Al-Asfour, Alexander K Bartella, Felix Gremse, Stefanie Rosenhain, Frank Hölzle, Peter Kessler, Bernd Lethaus
BACKGROUND: Alveolar cleft repair is performed via bone grafting procedure to restore the dental arch continuity. A suitable bone substitute materials should possess osteoinductive and osteoconductive properties, to promote new bone formation, along with a slowly resorbable scaffold that is subsequently replaced with functionally viable bone. Calcium phosphate biomaterials have long proved their efficacy as bone replacement materials. Dentin in several forms has also demonstrated its possibility to be used as bone graft replacement material in several studies...
December 23, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29243801/adverse-reactions-to-denture-resin-materials
#8
M Kostic, A Pejcic, M Igic, N Gligorijevic
Irrespective of the new generation of dental materials, acrylates still have a wide indication field. Although they are classified as biomaterials, acrylates can have both local and systemic side effects. The individual components of the acrylic materials may leave the dental restorations and diffuse into saliva. The aim of this study was to point out the potentially toxic components of acrylic dental materials, as well as their possible adverse effects on oral tissues and the organism in general. The paper was based on the assumption that the appropriate selection of the type of acrylic material and the proper method of their preparation reduce their adverse effects to a minimum, which was proven using literature data...
December 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29240210/three-dimensional-bone-augmentation-and-immediate-implant-placement-via-transcrestal-sinus-lift-five-year-clinical-outcomes
#9
Rosario Rizzo, Alessandro Quaranta, Massimo De Paoli, Giorgio Rappelli, Matteo Piemontese
This study proposed a surgical technique that solves three-dimensional conditions of extreme bone atrophy. A total of 278 surgeries with transcrestal sinus lift and fresh frozen allogenous bone blocks were performed. A total of 1,024 implants were placed. After 60 months of observation, 969 implants were considered grade I (successful), 24 grade II (satisfactory survival), and 8 grade III (compromised survival). The cumulative success and survival rates, respectively, were 94.6% and 97.7%. This innovative procedure is very effective in selected cases...
January 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29229545/fabrication-of-hybrid-crosslinked-network-with-buffering-capabilities-and-autonomous-strengthening-characteristics-for-dental-adhesive
#10
Linyong Song, Qiang Ye, Xueping Ge, Anil Misra, Candan Tamerler, Paulette Spencer
Ingress of bacteria and fluids at the interfacial gaps between the restorative composite biomaterial and the tooth structure contribute to recurrent decay and failure of the composite restoration. The inability of the material to increase the pH at the composite/tooth interface facilitates the outgrowth of bacteria. Neutralizing the microenvironment at the tooth/composite interface offers promise for reducing the damage provoked by cariogenic and aciduric bacteria. We address this problem by designing a dental adhesive composed of hybrid network to provide buffering and autonomous strengthening simultaneously...
December 8, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/29215170/synthetic-light-curable-polymeric-materials-provide-a-supportive-niche-for-dental-pulp-stem-cells
#11
Kyle H Vining, Jacob C Scherba, Alaina M Bever, Morgan R Alexander, Adam D Celiz, David J Mooney
Dental disease annually affects billions of patients, and while regenerative dentistry aims to heal dental tissue after injury, existing polymeric restorative materials, or fillings, do not directly participate in the healing process in a bioinstructive manner. There is a need for restorative materials that can support native functions of dental pulp stem cells (DPSCs), which are capable of regenerating dentin. A polymer microarray formed from commercially available monomers to rapidly identify materials that support DPSC adhesion is used...
December 7, 2017: Advanced Materials
https://www.readbyqxmd.com/read/29208280/formulation-and-biological-actions-of-nano-bioglass-ceramic-particles-doped-with-calcarea-phosphorica-for-bone-tissue-engineering
#12
S Dinesh Kumar, K Mohamed Abudhahir, N Selvamurugan, S Vimalraj, R Murugesan, N Srinivasan, A Moorthi
The improvisation of the treatment procedures for treating the various kind of bone defects such as, bone or dental trauma and for diseases such as osteoporosis, osteomyelitis etc., need the suitable and promising biomaterials with resemblance of bone components. Bioactive glass ceramic (BGC) has recently acquired great attention as the most promising biomaterials; hence it has been widely applied as a filler material for bone tissue regeneration. Because it elicts specific biological responses after implantation in addition more potential in formation of strong interface with both hard and soft tissues by dissolution of calcium and phosphate ions...
February 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29206139/alkaline-materials-and-regenerative-endodontics-a-review
#13
REVIEW
Bill Kahler, Nadia Chugal, Louis M Lin
Periapical health is the primary goal of endodontic treatment in mature and immature teeth. In addition, the goals of treatment of immature teeth with arrested root development include root growth to length and maturation of the apex, as well as thickening of the canal wall. These goals are valid for immature teeth that have been subjected to trauma and dental caries or that are the result of developmental anomalies that expose the tooth to the risk of pulp necrosis and consequently result in the cessation of root maturation...
December 5, 2017: Materials
https://www.readbyqxmd.com/read/29159178/zinc-containing-hydroxyapatite-enhances-cold-light-activated-tooth-bleaching-treatment-in-vitro
#14
Yi Li, Xinchang Shi, Wei Li
Cold-light bleaching treatment has grown to be a popular tooth whitening procedure in recent years, but its side effect of dental enamel demineralization is a widespread problem. The aim of this study was to synthesize zinc-substituted hydroxyapatite as an effective biomaterial to inhibit demineralization or increase remineralization. We synthesized zinc-substituted hydroxyapatite containing different zinc concentrations and analysed the product using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive spectrometer (EDS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29143221/controlling-streptococcus-mutans-and-staphylococcus-aureus-biofilms-with-direct-current-and-chlorhexidine
#15
Hao Wang, Dacheng Ren
Microbial biofilms formed on biomaterials are major causes of chronic infections. Among them, Gram-positive bacteria Streptococcus mutans and Staphylococcus aureus are important pathogens causing infections associated with dental caries (tooth-decay) and other medical implants. Unfortunately, current antimicrobial approaches are ineffective in disrupting established biofilms and new methods are needed to improve the efficacy. In this study, we report that the biofilm cells of S. mutans and S. aureus can be effectively killed by low-level direct current (DC) and through synergy in concurrent treatment with DC and chlorhexidine (CHX) at low concentrations...
November 15, 2017: AMB Express
https://www.readbyqxmd.com/read/29140371/biofunctionalization-of-titanium-granules-with-simvastatin-for-improving-osteogenic-activity-and-antibacterial-properties-ex-vivo-study
#16
Zahra Gorgin Karaji, Behzad Houshmand, Shahsanam Abbasi, Sara Shafiei, Shahab Faghihi
PURPOSE: Titanium-based biomaterials present good biocompatibility, while their osseointegration and antibacterial properties need to be improved. This study aimed to enhance the bone-bonding ability of titanium-based granules, which are intended to be used as bone graft. MATERIALS AND METHODS: The titanium granules were anodized in ethylene glycol-based electrolyte and subsequently annealed to be loaded separately with simvastatin. The samples were then inspected with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) for drug loading...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29130804/is-metal-particle-release-associated-with-peri-implant-bone-destruction-an-emerging-concept
#17
T Fretwurst, K Nelson, D P Tarnow, H-L Wang, W V Giannobile
Peri-implant diseases affecting the surrounding structures of endosseous dental implants include peri-implant mucositis and peri-implantitis. The prevalence of peri-implantitis ranges between 15% and 20% after 10 y, highlighting the major challenge in clinical practice in the rehabilitation of dental implant patients. The widespread nature of peri-implant bone loss poses difficulties in the management of biological complications affecting the long-term success of osseointegrated implant reconstructions. Metal and titanium particles have been detected in peri-implant supporting tissues...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29091020/do-clinical-and-radiological-assessments-contribute-to-the-understanding-of-biomaterials-results-from-a-prospective-randomized-sinus-augmentation-split-mouth-trial
#18
Jonas Lorenz, Tadas Korzinskas, Poju Chia, Sarah Al Maawi, Katrin Eichler, Robert Sader, Shahram Ghanaati
The present prospective randomized split-mouth trial reports on the 3-year clinical and radiological follow-up investigation of implants placed 7 months after sinus augmentation with two different bone substitute materials. Aim of the study was to complete the histologic observation of the cellular reactions by analysis of the implants and the volumetric changes of the augmented bone substitute materials. A sinus augmentation split-mouth trial was performed in 14 patients with the synthetic bone substitute material Nanobone® (NB) and the xenogeneic Bio-Oss® (BO)...
November 1, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29068426/preparation-and-characterization-of-resorbable-bacterial-cellulose-membranes-treated-by-electron-beam-irradiation-for-guided-bone-regeneration
#19
Sung-Jun An, So-Hyoun Lee, Jung-Bo Huh, Sung In Jeong, Jong-Seok Park, Hui-Jeong Gwon, Eun-Sook Kang, Chang-Mo Jeong, Youn-Mook Lim
Bacterial cellulose (BC) is an excellent biomaterial with many medical applications. In this study, resorbable BC membranes were prepared for guided bone regeneration (GBR) using an irradiation technique for applications in the dental field. Electron beam irradiation (EI) increases biodegradation by severing the glucose bonds of BC. BC membranes irradiated at 100 kGy or 300 kGy were used to determine optimal electron beam doses. Electron beam irradiated BC membranes (EI-BCMs) were evaluated by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermal gravimetric analysis (TGA), and using wet tensile strength measurements...
October 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29061354/odontogenic-potential-of-parathyroid-hormone-related-protein-107-111-alone-or%C3%A2-in%C3%A2-combination-with-mineral-trioxide-aggregate%C3%A2-in-human-dental-pulp-cells
#20
Jeong-Won Han, Bin-Na Lee, Se-Min Kim, Jeong-Tae Koh, Kyung-San Min, Yun-Chan Hwang
INTRODUCTION: Parathyroid hormone-related protein plays an important role in bone remodeling. Its N-terminal domain parathyroid hormone-related protein (107-111) is called osteostatin (OST). OST has demonstrated osteogenic potential when combined with biomaterials such as hydroxyapatite or bioceramics. However, the odontogenic potential of OST has not yet been reported. Therefore, the aim of this study was to determine whether OST has an odontogenic effect or a synergistic effect with mineral trioxide aggregate (MTA) in human dental pulp cells (hDPCs) and to examine the underlying signaling mechanisms involved in OST-mediated odontogenic differentiation...
October 20, 2017: Journal of Endodontics
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