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Dental Biomaterials

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https://www.readbyqxmd.com/read/29159178/zinc-containing-hydroxyapatite-enhances-cold-light-activated-tooth-bleaching-treatment-in-vitro
#1
Yi Li, Xinchang Shi, Wei Li
Cold-light bleaching treatment has grown to be a popular tooth whitening procedure in recent years, but its side effect of dental enamel demineralization is a widespread problem. The aim of this study was to synthesize zinc-substituted hydroxyapatite as an effective biomaterial to inhibit demineralization or increase remineralization. We synthesized zinc-substituted hydroxyapatite containing different zinc concentrations and analysed the product using X-ray diffraction (XRD), Fourier transform infrared (FTIR) spectroscopy, and energy dispersive spectrometer (EDS)...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29143221/controlling-streptococcus-mutans-and-staphylococcus-aureus-biofilms-with-direct-current-and-chlorhexidine
#2
Hao Wang, Dacheng Ren
Microbial biofilms formed on biomaterials are major causes of chronic infections. Among them, Gram-positive bacteria Streptococcus mutans and Staphylococcus aureus are important pathogens causing infections associated with dental caries (tooth-decay) and other medical implants. Unfortunately, current antimicrobial approaches are ineffective in disrupting established biofilms and new methods are needed to improve the efficacy. In this study, we report that the biofilm cells of S. mutans and S. aureus can be effectively killed by low-level direct current (DC) and through synergy in concurrent treatment with DC and chlorhexidine (CHX) at low concentrations...
November 15, 2017: AMB Express
https://www.readbyqxmd.com/read/29140371/biofunctionalization-of-titanium-granules-with-simvastatin-for-improving-osteogenic-activity-and-antibacterial-properties-ex-vivo-study
#3
Zahra Gorgin Karaji, Behzad Houshmand, Shahsanam Abbasi, Sara Shafiei, Shahab Faghihi
PURPOSE: Titanium-based biomaterials present good biocompatibility, while their osseointegration and antibacterial properties need to be improved. This study aimed to enhance the bone-bonding ability of titanium-based granules, which are intended to be used as bone graft. MATERIALS AND METHODS: The titanium granules were anodized in ethylene glycol-based electrolyte and subsequently annealed to be loaded separately with simvastatin. The samples were then inspected with attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR) for drug loading...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29130804/is-metal-particle-release-associated-with-peri-implant-bone-destruction-an-emerging-concept
#4
T Fretwurst, K Nelson, D P Tarnow, H-L Wang, W V Giannobile
Peri-implant diseases affecting the surrounding structures of endosseous dental implants include peri-implant mucositis and peri-implantitis. The prevalence of peri-implantitis ranges between 15% and 20% after 10 y, highlighting the major challenge in clinical practice in the rehabilitation of dental implant patients. The widespread nature of peri-implant bone loss poses difficulties in the management of biological complications affecting the long-term success of osseointegrated implant reconstructions. Metal and titanium particles have been detected in peri-implant supporting tissues...
November 1, 2017: Journal of Dental Research
https://www.readbyqxmd.com/read/29091020/do-clinical-and-radiological-assessments-contribute-to-the-understanding-of-biomaterials-results-from-a-prospective-randomized-sinus-augmentation-split-mouth-trial
#5
Jonas Lorenz, Tadas Korzinskas, Poju Chia, Sarah Al Maawi, Katrin Eichler, Robert Sader, Shahram Ghanaati
The present prospective randomized split-mouth trial reports on the 3-year clinical and radiological follow-up investigation of implants placed 7 months after sinus augmentation with two different bone substitute materials. Aim of the study was to complete the histologic observation of the cellular reactions by analysis of the implants and the volumetric changes of the augmented bone substitute materials. A sinus augmentation split-mouth trial was performed in 14 patients with the synthetic bone substitute material Nanobone® (NB) and the xenogeneic Bio-Oss® (BO)...
November 1, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29068426/preparation-and-characterization-of-resorbable-bacterial-cellulose-membranes-treated-by-electron-beam-irradiation-for-guided-bone-regeneration
#6
Sung-Jun An, So-Hyoun Lee, Jung-Bo Huh, Sung In Jeong, Jong-Seok Park, Hui-Jeong Gwon, Eun-Sook Kang, Chang-Mo Jeong, Youn-Mook Lim
Bacterial cellulose (BC) is an excellent biomaterial with many medical applications. In this study, resorbable BC membranes were prepared for guided bone regeneration (GBR) using an irradiation technique for applications in the dental field. Electron beam irradiation (EI) increases biodegradation by severing the glucose bonds of BC. BC membranes irradiated at 100 kGy or 300 kGy were used to determine optimal electron beam doses. Electron beam irradiated BC membranes (EI-BCMs) were evaluated by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermal gravimetric analysis (TGA), and using wet tensile strength measurements...
October 25, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29061354/odontogenic-potential-of-parathyroid-hormone-related-protein-107-111-alone-or%C3%A2-in%C3%A2-combination-with-mineral-trioxide-aggregate%C3%A2-in-human-dental-pulp-cells
#7
Jeong-Won Han, Bin-Na Lee, Se-Min Kim, Jeong-Tae Koh, Kyung-San Min, Yun-Chan Hwang
INTRODUCTION: Parathyroid hormone-related protein plays an important role in bone remodeling. Its N-terminal domain parathyroid hormone-related protein (107-111) is called osteostatin (OST). OST has demonstrated osteogenic potential when combined with biomaterials such as hydroxyapatite or bioceramics. However, the odontogenic potential of OST has not yet been reported. Therefore, the aim of this study was to determine whether OST has an odontogenic effect or a synergistic effect with mineral trioxide aggregate (MTA) in human dental pulp cells (hDPCs) and to examine the underlying signaling mechanisms involved in OST-mediated odontogenic differentiation...
October 20, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29056869/engineered-peptide-repairs-defective-adhesive-dentin-interface
#8
Qiang Ye, Paulette Spencer, Esra Yuca, Candan Tamerler
Failure of dental composite restorations is primarily due to recurrent decay at the tooth-composite interface. At this interface, the adhesive and its bond with dentin is the barrier between the restored tooth and the oral environment. In vivo degradation of the bond formed at the adhesive/dentin (a/d) interface follows a cascade of events leading to weakening of the composite restoration. Here, a peptide-based approach is developed to mineralize deficient dentin matrices at the a/d interface. Peptides that have an inherent capacity to self-assemble on dentin and to induce calcium-phosphate remineralization are anchored at the interface...
May 2017: Macromolecular Materials and Engineering
https://www.readbyqxmd.com/read/29045789/nano-hydroxyapatite-stimulation-of-gene-expression-requires-fgf-receptor-phosphate-transporter-and-erk1-2-signaling
#9
Shin-Woo Ha, Jonathan Park, Mark M Habib, George R Beck
Hydroxyapatite (HAp) is critical to health both as the main structural material of the skeleton and storage material of calcium and phosphate. Nanosized HAp (nHAp) is naturally produced by mineralizing cells during bone formation and remodeling and is the main constituent of the skeleton. As such, HAp is currently being investigated as a therapeutic biomaterial for orthopedic and dental purposes. Recent studies have suggested that extracellular nHAp can influence osteoblast lineage commitment and cell function through changes in gene expression; however, the mechanisms remain to be elucidated...
October 31, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29032813/light-cured-tricalcium-silicate-toxicity-to-the-dental-pulp
#10
Charlotte Jeanneau, Patrick Laurent, Charlotte Rombouts, Thomas Giraud, Imad About
INTRODUCTION: Numerous studies reported dentin bridge formation after pulp capping with tricalcium silicates. By contrast, pulp capping with resins leads to pulp toxicity and inflammation. Hybrid materials made up of tricalcium silicates and resins have also been developed to be used in direct pulp capping. This work was designed to study the consequences of adding resins to tricalcium silicates by investigating TheraCal (BISCO, Lançon De Provence, France) and Biodentine (Septodont, Saint Maur des Fosses, France) interactions with the dental pulp...
October 9, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/29029850/surface-characteristics-of-dental-implants-a-review
#11
REVIEW
F Rupp, L Liang, J Geis-Gerstorfer, L Scheideler, F Hüttig
OBJECTIVES: During the last decades, several changes of paradigm have modified our view on how biomaterials' surface characteristics influence the bioresponse. After becoming aware of the role of a certain microroughness for improved cellular contact and osseointegration of dental titanium implants, the likewise important role of surface energy and wettability was increasingly strengthened. Very recently, synergistic effects of nanoscaled topographical features and hydrophilicity at the implant/bone interface have been reported...
October 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29026693/platelet-rich-fibrin-a-paradigm-in-periodontal-therapy-a-systematic-review
#12
REVIEW
Umesh Pratap Verma, Rakesh Kumar Yadav, Manisha Dixit, Abhaya Gupta
Periodontal tissue regeneration has always been a challenge for the periodontists owing to its structural complexity. Although with tissue engineering as a growing multidisciplinary field, this aim has partially been fulfilled. In recent years, platelet-rich fibrin (PRF) has gained wide attention for its utilization as a biocompatible regenerative material not only in dental but also in medical fields. The following systematic review has gathered all the currently available in vitro, animal, and clinical studies utilizing PubMed electronic database from January 2006 to August 2016 highlighting PRF for soft and hard tissue regeneration and/or wound healing...
September 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29023390/electrospun-zein-gelatin-scaffold-enhanced-cell-attachment-and-growth-of-human-periodontal-ligament-stem-cells
#13
Fanqiao Yang, Yingling Miao, Yan Wang, Li-Ming Zhang, Xuefeng Lin
Periodontitis is a widespread dental disease affecting 10 to 15% of worldwide adult population, yet the current treatments are far from satisfactory. The human periodontal ligament stem cell is a promising potential seed cell population type in cell-based therapy and tissue regeneration, which require appropriate scaffold to provide a mimic extracellular matrix. Zein, a native protein derived from corn, has an excellent biodegradability, and therefore becomes a hotspot on research and application in the field of biomaterials...
October 12, 2017: Materials
https://www.readbyqxmd.com/read/29021982/autologous-periosteum-derived-micrografts-and-plga-ha-enhance-the-bone-formation-in-sinus-lift-augmentation
#14
Ruggero Rodriguez Y Baena, Riccardo D'Aquino, Antonio Graziano, Letizia Trovato, Antonio C Aloise, Gabriele Ceccarelli, Gabriella Cusella, André A Pelegrine, Saturnino M Lupi
Sinus lift augmentation is a procedure required for the placement of a dental implant, whose success can be limited by the quantity or quality of available bone. To this purpose, the first aim of the current study was to evaluate the ability of autologous periosteum-derived micrografts and Poly(lactic-co-glycolic acid) (PLGA) supplemented with hydroxyl apatite (HA) to induce bone augmentation in the sinus lift procedure. Secondly, we compared the micrograft's behavior with respect to biomaterial alone, including Bio-Oss® and PLGA/HA, commercially named Alos...
2017: Frontiers in Cell and Developmental Biology
https://www.readbyqxmd.com/read/28970865/understanding-biomaterial-tissue-interface-quality-combined-in-vitro-evaluation
#15
REVIEW
Michael Gasik
One of the greatest challenges in the development of new medical products and devices remains in providing maximal patient safety, efficacy and suitability for the purpose. A 'good quality' of the tissue-implant interface is one of the most critical factors for the success of the implant integration. In this paper this challenge is being discussed from the point of view of basic stimuli combination to experimental testing. The focus is in particular on bacterial effects on tissue-implant interaction (for different materials)...
2017: Science and Technology of Advanced Materials
https://www.readbyqxmd.com/read/28969628/bio-mimicking-nano-and-micro-structured-surface-fabrication-for-antibacterial-properties-in-medical-implants
#16
REVIEW
Alka Jaggessar, Hesam Shahali, Asha Mathew, Prasad K D V Yarlagadda
Orthopaedic and dental implants have become a staple of the medical industry and with an ageing population and growing culture for active lifestyles, this trend is forecast to continue. In accordance with the increased demand for implants, failure rates, particularly those caused by bacterial infection, need to be reduced. The past two decades have led to developments in antibiotics and antibacterial coatings to reduce revision surgery and death rates caused by infection. The limited effectiveness of these approaches has spurred research into nano-textured surfaces, designed to mimic the bactericidal properties of some animal, plant and insect species, and their topographical features...
October 2, 2017: Journal of Nanobiotechnology
https://www.readbyqxmd.com/read/28961487/esr-investigations-of-gamma-irradiated-medical-devices
#17
N Selcan Turker, A Yekta Özer, Şeyda Çolak, Burak Kutlu, Rahime Nohutçu
Guided tissue regeneration (GTR) and guided bone regeneration (GBR) biomaterials have been employed in recent years for periodontal procedures. In the present study, widely used dental GTR/GBR biomaterials (grafts: G1, G2, G3 and membranes: M1, M2, M3, M4) were exposed to gamma irradiation at an absorbed dose range of 0-50kGy and the radiolytic intermediates that have been created in the samples upon irradiation were characterized in detail by Electron Spin Resonance (ESR) spectroscopy. We aimed to standardize the measurement conditions for practical applications of gamma radiation sterilization of GTR/GBR biomaterials...
September 21, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28938034/influence-of-partial-o%C3%A2-pressure-on-the-adhesion-proliferation-and-osteogenic-differentiation-of-human-dental-pulp-stem-cells-on-%C3%AE-tricalcium-phosphate-scaffold
#18
Jose Viña-Almunia, Cristina Mas-Bargues, Consuelo Borras, Juan Gambini, Marya El Alami, Jorge Sanz-Ros, Miguel Peñarrocha, Jose Vina
PURPOSE: To analyze, in vitro, the influence of O₂ pressure on the adhesion, proliferation, and osteogenic differentiation of human dental pulp stem cells (DPSC) on β-tricalcium phosphate (β-TCP) scaffold. MATERIALS AND METHODS: DPSC, positive for the molecular markers CD133, Oct4, Nestin, Stro-1, and CD34, and negative for CD45, were isolated from extracted third molars. Experiments were started by seeding 200,000 cells on β-TCP cultured under 3% or 21% O₂ pressure...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28932309/the-effect-of-three-different-biomaterials-on-proliferation-and-viability-of-human-dental-pulp-stem-cells-in-vitro-study
#19
Dalia A Mohamed, Maha I Abdelfattah, Eman H A Aboulezz
BACKGROUND: Biomaterial cytotoxicity on dental stem cells plays a critical role in managing the regeneration of dental tissue. AIM: The aim of the present study was to evaluate the effect of Nano-hydroxy apatite (NHA), Mineral trioxide aggregate (MTA), and Calcium-enriched mixture (CEM) on the proliferation, and viability of human dental pulp stem cells (hDPSCs) isolated from third molar teeth. METHODS: Cultured DPSCs were characterized and the tested biomaterials were shaped into cylinders then inserted directly on the DPSCs...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28927925/optical-properties-of-zirconia-ceramics-for-esthetic-dental-restorations-a-systematic-review
#20
REVIEW
Reza Shahmiri, Owen Christopher Standard, Judy N Hart, Charles Christopher Sorrell
STATEMENT OF PROBLEM: Yttria-stabilized tetragonal zirconia polycrystal has been used as a dental biomaterial for several decades because the fracture toughness and bend strength are increased by a stress-induced transformation-toughening mechanism. However, its esthetics are compromised by its poor translucency and grayish-white appearance. PURPOSE: The purpose of the present systematic review was to assess information on the mechanical, chemical, and optical requirements of monolithic zirconia dental restorations...
September 16, 2017: Journal of Prosthetic Dentistry
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