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Dental Biomaterials

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https://www.readbyqxmd.com/read/27909893/osteogain%C3%A2-loaded-onto-an-absorbable-collagen-sponge-induces-attachment-and-osteoblast-differentiation-of-st2-cells-in-vitro
#1
Richard J Miron, Masako Fujioka-Kobayashi, Yufeng Zhang, Anton Sculean, Benjamin Pippenger, Yoshinori Shirakata, Umadevi Kandalam, Maria Hernandez
OBJECTIVES: Dimensional changes of the alveolar bone following tooth extraction are a major challenge in daily dental practice. To limit bone loss, a variety of biomaterials including bone grafts, barrier membranes, and growth factors have been utilized either alone or in combination therapies to increase the speed and quality of new bone formation. The aim of the present in vitro study was to investigate the regenerative potential of Osteogain®, a new liquid carrier system of enamel matrix derivative (EMD) in combination with an absorbable collagen sponge (ACS) specifically designed for extraction socket healing...
December 1, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27872014/the-bone-implant-interface-of-dental-implants-in-humans-on-the-atomic-scale
#2
Gustav Sundell, Christer Dahlin, Martin Andersson, Mattias Thuvander
: Osseointegration of dental implants occurs on a hierarchy of length scales down to the atomic level. A deeper understanding of the complex processes that take place at the surface of an implant on the smallest scale is of interest for the development of improved biomaterials. To date, transmission electron microscopy (TEM) has been utilized for examination of the bone-implant interface, providing details on the nanometer level. In this study we show that TEM imaging can be complemented with atom probe tomography (APT) to reveal the chemical composition of a Ti-based dental implant in a human jaw on the atomic level of resolution...
November 18, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27818690/stem-cells-of-dental-origin-current-research-trends-and-key-milestones-towards-clinical-application
#3
REVIEW
Athina Bakopoulou, Imad About
Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties. Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27806754/-issues-confronted-with-biomaterials-research-and-development-and-market-access-in-craniomaxillofacial-field
#4
M Hu
There are a variety of biomedical materials applied in craniomaxillofacial and dental clinical practice, plastic surgery, otorhinolaryngology and neurosurgery. With the increasing investment for the biomedical materials study, considerable progress has been obtained in biomaterials research. But overall, the field of biomaterials in China is still in a backward state. The development of advanced manufacturing technology has put forward new demands for the research of biological materials and has expanded the application, but at present, there are few biomaterials that meet the requirements...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27796686/biological-evaluation-of-ultrananocrystalline-and-nanocrystalline-diamond-coatings
#5
Shelby A Skoog, Girish Kumar, Jiwen Zheng, Anirudha V Sumant, Peter L Goering, Roger J Narayan
Nanostructured biomaterials have been investigated for achieving desirable tissue-material interactions in medical implants. Ultrananocrystalline diamond (UNCD) and nanocrystalline diamond (NCD) coatings are the two most studied classes of synthetic diamond coatings; these materials are grown using chemical vapor deposition and are classified based on their nanostructure, grain size, and sp(3) content. UNCD and NCD are mechanically robust, chemically inert, biocompatible, and wear resistant, making them ideal implant coatings...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27789947/effects-of-nanoporous-anodic-titanium-oxide-on-human-adipose-derived-stem-cells
#6
Katarzyna Malec, Joanna Góralska, Magdalena Hubalewska-Mazgaj, Paulina Głowacz, Magdalena Jarosz, Pawel Brzewski, Grzegorz D Sulka, Marian Jaskuła, Iwona Wybrańska
The aim of current bone biomaterials research is to design implants that induce controlled, guided, successful, and rapid healing. Titanium implants are widely used in dental, orthopedic, and reconstructive surgery. A series of studies has indicated that cells can respond not only to the chemical properties of the biomaterial, but also, in particular, to the changes in surface topography. Nanoporous materials remain in focus of scientific queries due to their exclusive properties and broad applications. One such material is nanostructured titanium oxide with highly ordered, mutually perpendicular nanopores...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27769674/saving-single-rooted-teeth-with-combined-endodontic-periodontal-lesions
#7
Alexandre Pico-Blanco, Pablo Castelo-Baz, Leticia Caneiro-Queija, Antonio Liñares-González, Pablo Martin-Lancharro, Juan Blanco-Carrión
INTRODUCTION: Teeth affected by combined endodontic-periodontal lesions are usually considered by all prognosis classifications as hopeless teeth. The development of new biomaterials combined with modern endodontic and periodontal regeneration techniques may improve dental prognosis and maintain the affected teeth. Moreover, 1 of the replacement options for those teeth, dental implants, has shown an increasing number of biological and technical complications. METHODS: Five patients were included in this case series study...
October 18, 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27763970/evaluation-of-the-biocompatibility-of-new-fiber-reinforced-composite-materials-for-craniofacial-bone-reconstruction
#8
Mădălina-Anca Lazar, Horaţiu Rotaru, Ioana Bâldea, Adina B Boşca, Cristian P Berce, Cristina Prejmerean, Doina Prodan, Radu S Câmpian
This study aims to assess the biocompatibility of new advanced fiber-reinforced composites (FRC) to be used for custom-made cranial implants. Four new formulations of FRC were obtained using polymeric matrices (combinations of monomers bisphenol A glycidylmethacrylate [bis-GMA], urethane dimethacrylate [UDMA], triethylene glycol dimethacrylate [TEGDMA], hydroxyethyl methacrylate [HEMA]) and E-glass fibers (300 g/mp). Every FRC contains 65% E-glass and 35% polymeric matrix. Composition of polymeric matrices are: bis-GMA (21%), TEGDMA (14%) for FRC1; bis-GMA (21%), HEMA (14%) for FRC2; bis-GMA (3...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27740641/tissue-integration-of-a-volume-stable-collagen-matrix-in-an-experimental-soft-tissue-augmentation-model
#9
Luca Ferrantino, Dieter Bosshardt, Myron Nevins, Giacomo Santoro, Massimo Simion, David Kim
Reducing the need for a connective tissue graft by using an efficacious biomaterial is an important task for dental professionals and patients. This experimental study aimed to test the soft tissue response to a volume-stable new collagen matrix. The device demonstrated good stability during six different time points ranging from 0 to 90 days of healing with no alteration of the wound-healing processes. The 90-day histologic specimen demonstrates eventual replacement of most of the matrix with new connective tissue fibers...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27728810/exosomes-as-biomimetic-tools-for-stem-cell-differentiation-applications-in-dental-pulp-tissue-regeneration
#10
Chun-Chieh Huang, Raghuvaran Narayanan, Satish Alapati, Sriram Ravindran
Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use of exosomes as biomimetic tools to induce stem cell differentiation. Working on the hypothesis that cell-type specific exosomes can trigger lineage-specific differentiation of stem cells, we have evaluated the potential of exosomes derived from dental pulp cells cultured on under growth and odontogenic differentiation conditions to induce odontogenic differentiation of naïve human dental pulp stem cells (DPSCs) and human bone marrow derived stromal cells (HMSCs) in vitro and in vivo...
December 2016: Biomaterials
https://www.readbyqxmd.com/read/27688777/the-neurovascular-properties-of-dental-stem-cells-and-their-importance-in-dental-tissue-engineering
#11
REVIEW
Jessica Ratajczak, Annelies Bronckaers, Yörg Dillen, Pascal Gervois, Tim Vangansewinkel, Ronald B Driesen, Esther Wolfs, Ivo Lambrichts, Petra Hilkens
Within the field of tissue engineering, natural tissues are reconstructed by combining growth factors, stem cells, and different biomaterials to serve as a scaffold for novel tissue growth. As adequate vascularization and innervation are essential components for the viability of regenerated tissues, there is a high need for easily accessible stem cells that are capable of supporting these functions. Within the human tooth and its surrounding tissues, different stem cell populations can be distinguished, such as dental pulp stem cells, stem cells from human deciduous teeth, stem cells from the apical papilla, dental follicle stem cells, and periodontal ligament stem cells...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27669885/use-of-platelet-concentrates-in-oral-and-maxillofacial-surgery-an-overview
#12
Zornitsa Mihaylova, Vanyo Mitev, Pavel Stanimirov, Antonia Isaeva, Natalia Gateva, Nikolay Ishkitiev
OBJECTIVE: To describe and provide a comprehensive overview on the development, use and efficacy of autologous platelet concentrates in different in vitro and in vivo studies focusing on oral and maxillofacial pathologies. MATERIALS AND METHODS: Present work employs an extensive critical overview of the literature on the development and application of platelet concentrates. RESULTS: Platelet concentrates are innovative endogenous therapeutic agents which gained a lot of interest in different medical and dental disciplines due to their potential ability to stimulate and increase regeneration of soft and hard tissues...
September 27, 2016: Acta Odontologica Scandinavica
https://www.readbyqxmd.com/read/27660601/effect-of-ag-addition-on-the-electrochemical-performance-of-cu10al-in-artificial-saliva
#13
R J Salgado-Salgado, J Porcayo-Calderon, O Sotelo-Mazon, R A Rodriguez-Diaz, G Salinas-Solano, V M Salinas-Bravo, L Martinez-Gomez
In this work we proposed to evaluate the corrosion resistance of four different alloys by electrochemical techniques, a binary alloy Cu10Al, and three ternary alloys Cu10Al-xAg (x = 5, 10, and 15 wt.%) to be used like biomaterials in dental application. Biomaterials proposed were tested in artificial saliva at 37°C for 48 h. In addition, pure metals Cu, Al, Ag, and Ti as reference materials were evaluated. In general the short time tests indicated that the Ag addition increases the corrosion resistance and reduces the extent of localized attack of the binary alloy...
2016: Bioinorganic Chemistry and Applications
https://www.readbyqxmd.com/read/27634479/magnetic-nanofiber-scaffold-induced-stimulation-of-odontogenesis-and-pro-angiogenesis-of-human-dental-pulp-cells-through-wnt-mapk-nf-%C3%AE%C2%BAb-pathways
#14
Hyung-Mun Yun, Soo-Kyung Kang, Rajendra K Singh, Jung-Hwan Lee, Hae-Hyoung Lee, Kyung-Ran Park, Jin-Kyu Yi, Deok-Won Lee, Hae-Won Kim, Eun-Cheol Kim
OBJECTIVE: Magnetic biomaterials have recently gained great attention due to their some intriguing cell and tissue responses. However, little attention has been given to the fields of dental tissue regeneration. In this sense, we aim to investigate the effects of magnetic nanofiber scaffolds on the human dental pulp cell (HDPC) behaviors and to elucidate the underlying signaling mechanisms in the events. METHODS: Magnetic nanofiber scaffolds incorporating magnetic nanoparticles at varying contents were prepared into nanofibrous matrices to cultivate cells...
September 12, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27612840/recent-advancements-in-regenerative-dentistry-a-review
#15
REVIEW
Pouya Amrollahi, Brinda Shah, Amir Seifi, Lobat Tayebi
Although human mouth benefits from remarkable mechanical properties, it is very susceptible to traumatic damages, exposure to microbial attacks, and congenital maladies. Since the human dentition plays a crucial role in mastication, phonation and esthetics, finding promising and more efficient strategies to reestablish its functionality in the event of disruption has been important. Dating back to antiquity, conventional dentistry has been offering evacuation, restoration, and replacement of the diseased dental tissue...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27612822/in-vitro-biocompatibility-of-titanium-after-plasma-surface-alloying-with-boron
#16
Mariusz Kaczmarek, Mieczysława U Jurczyk, Andrzej Miklaszewski, Anna Paszel-Jaworska, Aleksandra Romaniuk, Natalia Lipińska, Jakub Żurawski, Paulina Urbaniak, Karolina Jurczyk
Recently, the effect of different sizes of precursor powders during surface plasma alloying modification on the properties of titanium surface was studied. In this work we show in vitro test results of the titanium (α-Ti) after plasma surface alloying with boron (B). Ti-B nanopowders with 2 and 10wt% B were deposited onto microcrystalline Ti substrate. The in vitro cytocompatibility of these biomaterials was evaluated and compared with a conventional microcrystalline Ti. During the studies, established cell line of human gingival fibroblasts and osteoblasts were cultured in the presence of tested materials, and its survival rate and proliferation activity were examined...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27601281/a-quantitative-method-to-measure-biofilm-removal-efficiency-from-complex-biomaterial-surfaces-using-sem-and-image-analysis
#17
N Vyas, R L Sammons, O Addison, H Dehghani, A D Walmsley
Biofilm accumulation on biomaterial surfaces is a major health concern and significant research efforts are directed towards producing biofilm resistant surfaces and developing biofilm removal techniques. To accurately evaluate biofilm growth and disruption on surfaces, accurate methods which give quantitative information on biofilm area are needed, as current methods are indirect and inaccurate. We demonstrate the use of machine learning algorithms to segment biofilm from scanning electron microscopy images...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27593410/promotion-of-cells-to-close-gaps-and-encourage-cell-coverage-by-radio-frequency-glow-discharge-treatment
#18
Hanan Ali, Robert E Baier, Rosemary Dziak, Sebastiano Andreana
Exposure of dental abutments to cleaning and sterilizing Radio Frequency Glow Discharge Treatment (RFGDT) triggered greater degrees of human gingival fibroblast (HGF) attachment and spreading over their surfaces. Enhanced cell growth and metabolic activity of such HGFs were found which might lead to improved cellular margins in the smile-revealing "esthetic zone". This investigation, approved by the Institutional Review Board, employed in vitro studies of HGFs to support in vivo clinical applications of differentially treated titanium healing abutments to demonstrate the possible improvements for tissue growth around dental implants...
January 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27593160/isoexergonic-conformations-of-surface-bound-citrate-regulated-bioinspired-apatite-nanocrystal-growth
#19
Ziqiu Wang, Zhijun Xu, Weilong Zhao, Wei Chen, Toshikazu Miyoshi, Nita Sahai
The superior biomechanical properties of bone and dentin are dictated, in part, by the unique plate-like morphology of hydroxyapatite (HAP) nanocrysals within a hierarchically assembled collagen matrix. Understanding the mechanism of crystal growth and thus morphology is important to the rational design of bioinspired apatite nanocrystals for orthopedic and dental applications. Citrate has long been proposed to modulate apatite crystal growth, but major questions exist regarding the HAP-bound citrate conformations and the identities of the interacting functional groups and HAP surface sites...
October 5, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27546854/effect-of-biomaterials-on-angiogenesis-during-vital-pulp-therapy
#20
Mohammad Ali Saghiri, Armen Asatourian, Franklin Garcia-Godoy, Nader Sheibani
This review intended to provide an overview of the effects of dental materials, used in dentin-pulp complex and dental pulp regeneration, on angiogenesis processes during regenerative endodontic procedures. An electronic search was performed in PubMed and MEDLINE databases via OVID using the keywords mentioned in the PubMed and MeSH headings for English language published articles from January 2005-April 2014 that evaluated the angiogenic properties of different dental materials used in regenerative endodontic procedures...
October 1, 2016: Dental Materials Journal
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