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Dental Biomaterials

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https://www.readbyqxmd.com/read/28727999/drug-ion-co-delivery-multi-functional-nanocarrier-to-regenerate-infected-tissue-defect
#1
Jung-Hwan Lee, Ahmed El-Fiqi, Nandin Mandakhbayar, Hae-Hyoung Lee, Hae-Won Kim
Regeneration of infected tissues is a globally challenging issue in medicine and dentistry. Common clinical therapies involving a complete removal of infected areas together with a treatment of antimicrobial drugs are often suboptimal. Biomaterials with anti-bacterial and pro-regenerative potential can offer a solution to this. Here we design a novel nanocarrier based on a mesoporous silicate-calcium glass by doping with Ag ions and simultaneously loading antimicrobial drugs onto mesopores. The nanocarriers could controllably release multiple ions (silver, calcium, and silicate) and drugs (tetracycline or chlorohexidine) to levels therapeutically relevant, and effectively internalize to human dental stem cells (∼90%) with excellent viability, ultimately stimulating odontogenic differentiation...
July 12, 2017: Biomaterials
https://www.readbyqxmd.com/read/28714053/the-influence-of-surface-texture-and-wettability-on-initial-bacterial-adhesion-on-titanium-and-zirconium-oxide-dental-implants
#2
Torsten Wassmann, Stefan Kreis, Michael Behr, Ralf Buergers
BACKGROUND: This study aims to investigate bacterial adhesion on different titanium and ceramic implant surfaces, to correlate these findings with surface roughness and surface hydrophobicity, and to define the predominant factor for bacterial adhesion for each material. METHODS: Zirconia and titanium specimens with different surface textures and wettability (5.0 mm in diameter, 1.0 mm in height) were prepared. Surface roughness was measured by perthometer (R a ) and atomic force microscopy, and hydrophobicity according to contact angles by computerized image analysis...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28711686/hydrogel-elasticity-and-microarchitecture-regulate-dental-derived-mesenchymal-stem-cells-host-immune-system-cross-talk
#3
Sahar Ansari, Chider Chen, Mohammad Mahdi Hasani-Sadrabadi, Bo Yu, Homayoun H Zadeh, Benjamin M Wu, Alireza Moshaverinia
The host immune system (T-lymphocytes and their pro-inflammatory cytokines) has been shown to compromise bone regeneration ability of mesenchymal stem cells (MSCs). We have recently shown that hydrogel, used as an encapsulating biomaterial affects the cross-talk among host immune cells and MSCs. However, the role of hydrogel elasticity and porosity in regulation of cross-talk between dental-derived MSCs and immune cells is unclear. In this study, we demonstrate that the modulus of elasticity and porosity of the scaffold influence T-lymphocyte-dental MSC interplay by regulating the penetration of inflammatory T cells and their cytokines...
July 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28683765/periodontal-regenerative-therapy-with-enamel-matrix-derivative-in-the-treatment-of-intrabony-defects-a-prospective-2-year-study
#4
Fumi Seshima, Hideto Aoki, Takahiro Takeuchi, Eiichi Suzuki, Daisuke Irokawa, Asako Makino-Oi, Hiroki Sugito, Sachiyo Tomita, Atsushi Saito
OBJECTIVE: To date, enamel matrix derivative (EMD) has been considered to be one of the few biomaterials for clinical use capable of demonstrating true periodontal regeneration. The aim of this two-center prospective clinical study was to evaluate 2-year outcome of periodontal regenerative therapy using EMD in the treatment of intrabony defects, performed as an 'advanced medical treatment' under the national healthcare system in Japan. RESULTS: Patients with chronic periodontitis who have completed initial periodontal therapy at either of the two dental school clinics were enrolled...
July 6, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28680712/comparative-randomized-double-blind-clinical-study-of-alveolar-ridge-preservation-using-an-extracellular-matrix-based-dental-resorbable-membrane-in-the-extraction-socket
#5
Hyeyoon Chang, Sulhee Kim, Jin Wook Hwang, Sungtae Kim, Ki-Tae Koo, Tae-Il Kim, Yang-Jo Seol, Yong-Moo Lee, Young Ku, Jong-Ho Lee, In-Chul Rhyu
PURPOSE: The aim of this study was to radiographically and clinically compare the effect of extracellular matrix (ECM) membranes on dimensional alterations following a ridge preservation procedure. METHODS: One of 2 different ECM membranes was applied during a ridge preservation procedure. A widely used ECM membrane (WEM; Bio-Gide, Geistlich Biomaterials, Wolhusen, Switzerland) was applied in the treatment group and a newly developed ECM membrane (NEM; Lyso-Gide, Oscotec Inc...
June 2017: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28680554/characterization-and-antimicrobial-efficacy-of-portland-cement-impregnated-with-silver-nanoparticles
#6
Ki Young Nam
PURPOSE: This study investigated the effects of silver nanoparticle (SN) loading into hydraulic calcium silicate-based Portland cement on its mechanical, antibacterial behavior and biocompatibility as a novel dental bone substitute. MATERIALS AND METHODS: Chemically reduced colloidal SN were combined with Portland cement (PC) by the concentrations of 0 (control), 1.0, 3.0, and 5.0 wt%. The physico-mechanical properties of silver-Portland cement nanocomposites (SPNC) were investigated through X-ray diffraction (XRD), setting time, compressive strength, solubility, and silver ion elution...
June 2017: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/28676434/multifunctional-bioactive-glass-and-glass-ceramic-biomaterials-with-antibacterial-properties-for-repair-and-regeneration-of-bone-tissue
#7
REVIEW
João S Fernandes, Piergiorgio Gentile, Ricardo A Pires, Rui L Reis, Paul V Hatton
Bioactive glasses (BGs) and related glass-ceramic biomaterials have been used in bone tissue repair for over 30years. Previous work in this field was comprehensively reviewed including by their inventor Larry Hench, and the key features and properties of BGs are well understood. More recently, attention has focused on their modification to further enhance the osteogenic behaviour, or further compositional changes that may introduce additional properties, such as antimicrobial activity. Evidence is emerging that BGs and related glass-ceramics may be modified in such a way as to simultaneously introduce more than one desirable property...
July 1, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28675640/characterization-of-serum-proteins-attached-to-distinct-sol-gel-hybrid-surfaces
#8
Nuno Araújo-Gomes, Francisco Romero-Gavilán, Ana M Sánchez-Pérez, Marilo Gurruchaga, Mikel Azkargorta, Felix Elortza, María Martinez-Ibañez, Ibon Iloro, Julio Suay, Isabel Goñi
The success of a dental implant depends on its osseointegration, an important feature of the implant biocompatibility. In this study, two distinct sol-gel hybrid coating formulations [50% methyltrimethoxysilane: 50% 3-glycidoxypropyl-trimethoxysilane (50M50G) and 70% methyltrimethoxysilane with 30% tetraethyl orthosilicate (70M30T)] were applied onto titanium implants. To evaluate their osseointegration, in vitro and in vivo assays were performed. Cell proliferation and differentiation in vitro did not show any differences between the coatings...
July 4, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28655657/peptide-functionalized-poly-oligo-ethylene-glycol-methacrylate-brushes-on-dopamine-coated-stainless-steel-for-controlled-cell-adhesion
#9
Guillermo R Alas, Rachit Agarwal, David M Collard, Andrés J García
The modification of the surface of surgical implants with cell adhesion ligands has emerged as a promising approach to improve biomaterial-host interactions. However, these approaches are limited by the non-specific adsorption of biomolecules and uncontrolled presentation of desired bioactive ligands on implant surfaces. This leads to sub-optimal integration with host tissue and delayed healing. Here we present a strategy to grow non-fouling polymer brushes of oligo(ethylene glycol) methacrylate by atom transfer radical polymerization from dopamine-functionalized clinical grade 316 stainless steel...
June 24, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28653139/spreading-proliferation-and-differentiation-of-human-dental-pulp-stem-cells-on-chitosan-scaffolds-immobilized-with-rgd-or-fibronectin
#10
Farzin Asghari Sana, Merve Çapkın Yurtsever, Gökçe Kaynak Bayrak, Ekin Özge Tunçay, Arlin S Kiremitçi, Menemşe Gümüşderelioğlu
Nowadays, human dental pulp stem cells (hDPSCs) became more attractive for therapeutic purposes because of their high proliferation and differentiation potential. Thus, coupling the desired cellular characteristics of hDPSCs with good biomaterial properties of the chitosan scaffolds provide an interesting approach for tissue engineering applications. On the other hand, scaffold surface modification is also needed to promote stem cell adhesion since chitosan lacks adhesion motifs to support direct cell anchorage...
June 26, 2017: Cytotechnology
https://www.readbyqxmd.com/read/28652733/in-vitro-studies-of-nanosilver-doped-titanium-implants-for-oral-and-maxillofacial-surgery
#11
Rafał Pokrowiecki, Tomasz Zaręba, Barbara Szaraniec, Krzysztof Pałka, Agnieszka Mielczarek, Elżbieta Menaszek, Stefan Tyski
The addition of an antibacterial agent to dental implants may provide the opportunity to decrease the percentage of implant failures due to peri-implantitis. For this purpose, in this study, the potential efficacy of nanosilver-doped titanium biomaterials was determined. Titanium disks were incorporated with silver nanoparticles over different time periods by Tollens reaction, which is considered to be an eco-friendly, cheap, and easy-to-perform method. The surface roughness, wettability, and silver release profile of each disc were measured...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28649171/injectable-scaffolds-preparation-and-application-in-dental-and-craniofacial-regeneration
#12
Bei Chang, Neelam Ahuja, Chi Ma, Xiaohua Liu
Injectable scaffolds are appealing for tissue regeneration because they offer many advantages over pre-formed scaffolds. This article provides a comprehensive review of the injectable scaffolds currently being investigated for dental and craniofacial tissue regeneration. First, we provide an overview of injectable scaffolding materials, including natural, synthetic, and composite biomaterials. Next, we discuss a variety of characteristic parameters and gelation mechanisms of the injectable scaffolds. The advanced injectable scaffolding systems developed in recent years are then illustrated...
January 2017: Materials Science & Engineering. R, Reports: a Review Journal
https://www.readbyqxmd.com/read/28644556/sinus-augmentation-using-a-mini-pig-model-effect-of-ceramic-and-allogeneic-bone-biomaterials
#13
Cristiano Susin, Tiago Fiorini, Jaebum Lee, Rubens Moreno de Freitas, Hsien-Chung Chiu, Hari S Prasad, Amanda N Buxton, Ulf Me Wikesjö
BACKGROUND: Present clinical practice broadly relies on off-the-shelf allogeneic, xenogeneic or synthetic bone biomaterials in support of sinus augmentation. Also, recombinant human bone morphogenetic protein-2 in an absorbable collagen sponge carrier (rhBMP-2/ACS) has been shown to support clinically relevant bone formation when used to augment the maxillary sinus. OBJECTIVES: To evaluate local bone formation/dental implant osseointegration following implantation of two particulate bone biomaterials using the mini-pig sinus augmentation model...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28643883/is-ridge-preservation-augmentation-at-periodontally-compromised-extraction-sockets-safe-a-retrospective-study
#14
Jung-Ju Kim, Heithem Ben Amara, Frank Schwarz, Hae-Young Kim, Jung-Won Lee, Ulf Me Wikesjö, Ki-Tae Koo
OBJECTIVES: This study aimed to evaluate the safety of ridge preservation/augmentation procedures when performed at compromised extraction sockets. METHODS: Patients subject to ridge preservation/augmentation at periodontally compromised sockets at Seoul National University Dental Hospital(SNUDH) were evaluated in a chart review. Tooth extractions due to acute infection were not included in our study as chronically formed lesions are the only lesions that can be detected from radiographic images...
June 23, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28642917/a-new-era-considering-inorganic-trace-elements-and-biological-activity-of-dental-biomaterials-angiogenic-activity
#15
Mohammad Ali Saghiri, Armen Asatourian, Franklin Garcia-Godoy, Nader Sheibani
No abstract text is available yet for this article.
December 2016: Acta Biomaterialia Odontologica Scandinavica
https://www.readbyqxmd.com/read/28642517/green-dentistry-the-art-and-science-of-sustainable-practice
#16
P Mulimani
Dentistry is highly energy and resource intensive with significant environmental impact. Factors inherent in the profession such as enormous electricity demands of electronic dental equipment, voluminous water requirements, environmental effects of biomaterials (before, during and after clinical use), the use of radiation and the generation of hazardous waste involving mercury, lead etc have contributed towards this. With rising temperatures across the world due to global warming, efforts are being made worldwide to mitigate the effects of environmental damage by resorting to sustainability concepts and green solutions in a myriad of ways...
June 23, 2017: British Dental Journal
https://www.readbyqxmd.com/read/28633093/fracture-resistance-of-ceramic-and-polymer-based-occlusal-veneer-restorations
#17
Majed Al-Akhali, Mohamed Sad Chaar, Adham Elsayed, Abdulaziz Samran, Matthias Kern
OBJECTIVES: The purpose of this in vitro study was to evaluate the influence of thermodynamic loading on the durability and fracture resistance behavior of occlusal veneers fabricated from different biomedical dental CAD/CAM materials. METHODS: The occlusal surfaces of 64 extracted premolars were prepared in the enamel layer and restored with occlusal veneers with a fissure/cusp thickness of 0.5/0.8mm made from four different dental CAD/CAM materials: group LD lithium disilicate (e...
June 13, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28621746/biocompatibility-analyses-of-al%C3%A2-o%C3%A2-treated-titanium-plates-tested-with-osteocyte-and-fibroblast-cell-lines
#18
Alberto Smargiassi, Jessika Bertacchini, Marta Checchi, Francesco Cavani, Marzia Ferretti, Carla Palumbo
Osseointegration of a titanium implant is still an issue in dental/orthopedic implants durable over time. The good integration of these implants is mainly due to their surface and topography. We obtained an innovative titanium surface by shooting different-in-size particles of Al₂O₃ against the titanium scaffolds which seems to be ideal for bone integration. To corroborate that, we used two different cell lines: MLO-Y4 (murine osteocytes) and 293 (human fibroblasts) and tested the titanium scaffolds untreated and treated (i...
June 16, 2017: Biomedicines
https://www.readbyqxmd.com/read/28595164/imaging-and-analysis-of-individual-cavitation-microbubbles-around-dental-ultrasonic-scalers
#19
N Vyas, H Dehghani, R L Sammons, Q X Wang, D M Leppinen, A D Walmsley
Cavitation is a potentially effective and less damaging method of removing biofilm from biomaterial surfaces. The aim of this study is to characterise individual microbubbles around ultrasonic scaler tips using high speed imaging and image processing. This information will provide improved understanding on the disruption of dental biofilm and give insights into how the instruments can be optimised for ultrasonic cleaning. Individual cavitation microbubbles around ultrasonic scalers were analysed using high speed recordings up to a million frames per second with image processing of the bubble movement...
November 2017: Ultrasonics
https://www.readbyqxmd.com/read/28561919/current-trends-and-future-perspectives-of-dental-pulp-capping-materials-a-systematic-review
#20
REVIEW
Wellington L O da Rosa, Alexandra R Cocco, Tiago M da Silva, Luana C Mesquita, Arthur Dias Galarça, Adriana F da Silva, Evandro Piva
To systematically review the literature to analyze the current trends and future perspectives of dental pulp capping materials through an analysis of scientific and technological data. This study is reported in accordance with the PRISMA Statement. Nine databases were screened: PubMed (MedLine), Lilacs, IBECS, BBO, Web of Science, Scopus, SciELO, Google Scholar, and The Cochrane Library. Additionally, the following patent applications were searched online in Questel Orbit (Paris, France), USPTO, EPO, JPO, INPI, and Patentscope databases...
May 31, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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