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Dental Biomaterials

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https://www.readbyqxmd.com/read/28938034/influence-of-partial-o%C3%A2-pressure-on-the-adhesion-proliferation-and-osteogenic-differentiation-of-human-dental-pulp-stem-cells-on-%C3%AE-tricalcium-phosphate-scaffold
#1
Jose Viña-Almunia, Cristina Mas-Bargues, Consuelo Borras, Juan Gambini, Marya El Alami, Jorge Sanz-Ros, Miguel Peñarrocha, Jose Vina
PURPOSE: To analyze, in vitro, the influence of O₂ pressure on the adhesion, proliferation, and osteogenic differentiation of human dental pulp stem cells (DPSC) on β-tricalcium phosphate (β-TCP) scaffold. MATERIALS AND METHODS: DPSC, positive for the molecular markers CD133, Oct4, Nestin, Stro-1, and CD34, and negative for CD45, were isolated from extracted third molars. Experiments were started by seeding 200,000 cells on β-TCP cultured under 3% or 21% O₂ pressure...
September 22, 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/28932309/the-effect-of-three-different-biomaterials-on-proliferation-and-viability-of-human-dental-pulp-stem-cells-in-vitro-study
#2
Dalia A Mohamed, Maha I Abdelfattah, Eman H A Aboulezz
BACKGROUND: Biomaterial cytotoxicity on dental stem cells plays a critical role in managing the regeneration of dental tissue. AIM: The aim of the present study was to evaluate the effect of Nano-hydroxy apatite (NHA), Mineral trioxide aggregate (MTA), and Calcium-enriched mixture (CEM) on the proliferation, and viability of human dental pulp stem cells (hDPSCs) isolated from third molar teeth. METHODS: Cultured DPSCs were characterized and the tested biomaterials were shaped into cylinders then inserted directly on the DPSCs...
August 15, 2017: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28927925/optical-properties-of-zirconia-ceramics-for-esthetic-dental-restorations-a-systematic-review
#3
REVIEW
Reza Shahmiri, Owen Christopher Standard, Judy N Hart, Charles Christopher Sorrell
STATEMENT OF PROBLEM: Yttria-stabilized tetragonal zirconia polycrystal has been used as a dental biomaterial for several decades because the fracture toughness and bend strength are increased by a stress-induced transformation-toughening mechanism. However, its esthetics are compromised by its poor translucency and grayish-white appearance. PURPOSE: The purpose of the present systematic review was to assess information on the mechanical, chemical, and optical requirements of monolithic zirconia dental restorations...
September 16, 2017: Journal of Prosthetic Dentistry
https://www.readbyqxmd.com/read/28866015/chitosan-as-biomaterial-in-drug-delivery-and-tissue-engineering
#4
REVIEW
Saad M Ahsan, Mathai Thomas, Kranthi K Reddy, Sujata Gopal Sooraparaju, Amit Asthana, Ira Bhatnagar
Chitin is one of the most abundant polysaccharide found on earth. The deacetylated form of chitin viz. chitosan has been reported for its various important pharmacological properties and its role in tissue engineering and regenerative medicine is also well documented. Chitosan based bone graft substitutes are biocompatible, biodegradable, osteoconductive, osteoinductive and structurally similar to bone, with excellent mechanical strength and cost effectiveness. Chitosan based hydrogels and wound healing bandages have also found a great market in the field of medicine...
August 30, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28865173/the-extracts-of-bredigite-bioceramics-enhanced-the-pluripotency-of-human-dental-pulp-cellss
#5
Lihong Chen, Lu Liu, Chengtie Wu, Ruiqi Yang, Jiang Chang, Xi Wei
Biomaterials have a profound effect on tissue engineering and regenerative medicine, but few studies have reported the role of extracts from bioceramics in the regulation of stem cell pluripotency. The present study investigated the effects of bioceramics extracts, including silicate bredigite (Ca7 MgSi4 O16 ) and conventional β-tricalcium phosphate (β-TCP), on the pluripotency and the multilineage differentiation potential of human dental pulp cells (hDPCs). Basic fibroblast growth factor (bFGF), which is a known regulator of hDPCs pluripotency, was used as a reference...
September 2, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28862689/the-efficacy-of-electron-beam-irradiated-bacterial-cellulose-membranes-as-compared-with-collagen-membranes-on-guided-bone-regeneration-in-peri-implant-bone-defects
#6
So-Hyoun Lee, Sung-Jun An, Youn-Mook Lim, Jung-Bo Huh
Bacterial cellulose (BC) is a natural polysaccharide produced by some bacteria, and consists of a linear polymer linked by β-(1,4) glycosidic bonds. BC has been developed as a material for tissue regeneration purposes. This study was conducted to evaluate the efficacy of resorbable electron beam irradiated BC membranes (EI-BCMs) for guided bone regeneration (GBR). The electron beam irradiation (EI) was introduced to control the biodegradability of BC for dental applications. EI-BCMs had higher porosity than collagen membranes (CMs), and had similar wet tensile strengths to CMs...
September 1, 2017: Materials
https://www.readbyqxmd.com/read/28855754/clinical-evaluation-of-mineral-trioxide-aggregate-and-biodentine-as-direct-pulp-capping-agents-in-carious-teeth
#7
Swaroop Hegde, B Sowmya, Sylvia Mathew, Shilpa H Bhandi, Shruthi Nagaraja, K Dinesh
BACKGROUND: Root canal treatment has been a routine treatment option for carious exposure of the dental pulp. In the context of minimally invasive dentistry, direct pulp capping (DPC) procedure with a reliable biomaterial may be considered as an alternative provided the pulp status is favorable. Mineral trioxide aggregate (MTA), a bioactive cement with excellent sealing ability and biocompatibility is capable of regenerating relatively damaged pulp and formation of dentin bridge when used as DPC agent...
March 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/28852742/attachment-and-growth-of-human-osteoblasts-on-different-biomaterial-surfaces
#8
Stefan Bubik, Michael Payer, Gerwin Arnetzl, Heike Kaltenegger, Andreas Leithner, Arnold Klampfl, Birgit Lohberger
OBJECTIVES: To prove the biocompatibility of biomaterials applied in biomedical devices, in vitro testing is crucial to render a material fit for medical application. The material of choice for dental implants is commercially pure titanium (cp-Ti), while other materials such as zirconia and polyetheretherketone (PEEK) are considered highly promising due to their functional and esthetic properties. The aim of this study was to determine whether PEEK with defined mean surface roughness and composition could achieve results equal to titanium or zirconia...
2017: International Journal of Computerized Dentistry
https://www.readbyqxmd.com/read/28837748/tuning-the-response-of-osteoblast-like-cells-to-the-porous-alumina-assisted-mixed-oxide-nano-mound-arrays
#9
Zdenka Fohlerova, Alexander Mozalev
Nanostructuring of biomaterials is used to create an appropriate interfacial layer that promotes stable cellular adhesion, proliferation, and differentiation on orthopedic and dental implants. Here, we synthesize self-organized arrays of composite-oxide nano-mounds through anodizing Al/Ta bilayers sputtered on substrates to cover the "missing" smallest size range of 10-40 nm for structuring an advanced inorganic biomaterial-Al2 O3 -doped Ta2 O5 films. The osteoblast-like cells appear to be able to recognize the finest differences in the film nano-morphologies...
August 24, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28828153/effect-of-polyethelene-oxide-on-the-thermal-degradation-of-cellulose-biofilm-low-cost-material-for-soft-tissue-repair-in-dentistry
#10
Anna Akkus, Rakim Tyler, David Schiraldi, Renato Roperto, Fady Faddoul, Sorin Teich
BACKGROUND: Bio cellulose is a byproduct of sweet tea fermentation known as kombusha. During the biosynthesis by bacteria cellulose chains are polymerized by enzyme from activated glucose. The single chains are then extruded through the bacterial cell wall. Interestingly, a potential of the Kombucha's byproduct bio cellulose (BC) as biomaterial had come into focus only in the past few decades. The unique physical and mechanical properties such as high purity, an ultrafine and highly crystalline network structure, a superior mechanical strength, flexibility, pronounced permeability to gases and liquids, and an excellent compatibility with living tissue that reinforced by biodegradability, biocompatibility, large swelling ratios...
July 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28822139/confocal-raman-mapping-of-collagen-cross-link-and-crystallinity-of-human-dentin-enamel-junction
#11
Amel Slimani, Fares Nouioua, Alban Desoutter, Bernard Levallois, Frédéric J G Cuisinier, Hervé Tassery, Elodie Terrer, Hamideh Salehi
The separation zone between enamel and dentin [dentin-enamel junction (DEJ)] with different properties in biomechanical composition has an important role in preventing crack propagation from enamel to dentin. The understanding of the chemical structure (inorganic and organic components), physical properties, and chemical composition of the human DEJ could benefit biomimetic materials in dentistry. Spatial distribution of calcium phosphate crystallinity and the collagen crosslinks near DEJ were studied using confocal Raman microscopy and calculated by different methods...
August 2017: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/28817668/titanium-biomaterials-with-complex-surfaces-induced-aberrant-peripheral-circadian-rhythms-in-bone-marrow-mesenchymal-stromal-cells
#12
Nathaniel Hassan, Kirstin McCarville, Kenzo Morinaga, Cristiane M Mengatto, Peter Langfelder, Akishige Hokugo, Yu Tahara, Christopher S Colwell, Ichiro Nishimura
Circadian rhythms maintain a high level of homeostasis through internal feed-forward and -backward regulation by core molecules. In this study, we report the highly unusual peripheral circadian rhythm of bone marrow mesenchymal stromal cells (BMSCs) induced by titanium-based biomaterials with complex surface modifications (Ti biomaterial) commonly used for dental and orthopedic implants. When cultured on Ti biomaterials, human BMSCs suppressed circadian PER1 expression patterns, while NPAS2 was uniquely upregulated...
2017: PloS One
https://www.readbyqxmd.com/read/28773240/metallic-biomaterials-current-challenges-and-opportunities
#13
REVIEW
Karthika Prasad, Olha Bazaka, Ming Chua, Madison Rochford, Liam Fedrick, Jordan Spoor, Richard Symes, Marcus Tieppo, Cameron Collins, Alex Cao, David Markwell, Kostya Ken Ostrikov, Kateryna Bazaka
Metallic biomaterials are engineered systems designed to provide internal support to biological tissues and they are being used largely in joint replacements, dental implants, orthopaedic fixations and stents. Higher biomaterial usage is associated with an increased incidence of implant-related complications due to poor implant integration, inflammation, mechanical instability, necrosis and infections, and associated prolonged patient care, pain and loss of function. In this review, we will briefly explore major representatives of metallic biomaterials along with the key existing and emerging strategies for surface and bulk modification used to improve biointegration, mechanical strength and flexibility of biometals, and discuss their compatibility with the concept of 3D printing...
July 31, 2017: Materials
https://www.readbyqxmd.com/read/28772963/chitosan-biomaterials-for-current-and-potential-dental-applications
#14
REVIEW
Shehriar Husain, Khalid H Al-Samadani, Shariq Najeeb, Muhammad S Zafar, Zohaib Khurshid, Sana Zohaib, Saad B Qasim
Chitosan (CHS) is a very versatile natural biomaterial that has been explored for a range of bio-dental applications. CHS has numerous favourable properties such as biocompatibility, hydrophilicity, biodegradability, and a broad antibacterial spectrum (covering gram-negative and gram-positive bacteria as well as fungi). In addition, the molecular structure boasts reactive functional groups that provide numerous reaction sites and opportunities for forging electrochemical relationships at the cellular and molecular levels...
May 31, 2017: Materials
https://www.readbyqxmd.com/read/28772863/current-insights-into-the-modulation-of-oral-bacterial-degradation-of-dental-polymeric-restorative-materials
#15
REVIEW
Ning Zhang, Yansong Ma, Michael D Weir, Hockin H K Xu, Yuxing Bai, Mary Anne S Melo
Dental polymeric composites have become the first choice for cavity restorations due to their esthetics and capacity to be bonded to the tooth. However, the oral cavity is considered to be harsh environment for a polymeric material. Oral biofilms can degrade the polymeric components, thus compromising the marginal integrity and leading to the recurrence of caries. Recurrent caries around restorations has been reported as the main reason for restoration failure. The degradation of materials greatly compromises the clinical longevity...
May 6, 2017: Materials
https://www.readbyqxmd.com/read/28764283/fabrication-and-appraisal-of-poly-lactic-co-glycolic-acid-moxifloxacin-nanoparticles-using-vitamin-e-tpgs-a-potential-intracanal-drug-delivery-agent
#16
Hardik Makkar, Gaurav Patri
INTRODUCTION: Nanotechnology is gaining momentum in the search for ideal biomaterials by dental researchers. The expansible nature of Endodontology deems exploration, learning and scrutinizing newer avenues which have the potential to be applied and investigated. The popularity of polymers as drug delivery vehicles has opened avenues for their application in the root canal system. This study utilized application of biodegradable polymers as potential drug delivery vehicles against Enterococcus faecalis, one of the main reasons for post treatment disease...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28761445/in-vitro-and-in-vivo-dentinogenic-efficacy-of-human-dental-pulp-derived-cells-induced-by-demineralized-dentin-matrix-and-ha-tcp
#17
Kyung-Jung Kang, Min Suk Lee, Chan-Woong Moon, Jae-Hoon Lee, Hee Seok Yang, Young-Joo Jang
Human dental pulp cells have been known to have the stem cell features such as self-renewal and multipotency. These cells are differentiated into hard tissue by addition of proper cytokines and biomaterials. Hydroxyapatite-tricalcium phosphates (HA-TCPs) are essential components of hard tissue and generally used as a biocompatible material in tissue engineering of bone. Demineralized dentin matrix (DDM) has been reported to increase efficiency of bone induction. We compared the efficiencies of osteogenic differentiation and in vivo bone formation of HA-TCP and DDM on human dental pulp stem cells (hDPSCs)...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28758916/effect-of-a-particulate-and-a-putty-like-tricalcium-phosphate-based-bone-grafting-material-on-bone-formation-volume-stability-and-osteogenic-marker-expression-after-bilateral-sinus-floor-augmentation-in-humans
#18
Christine Knabe, Doaa Adel-Khattab, Esther Kluk, Rainer Struck, Michael Stiller
This study examines the effect of a hyaluronic acid (HyAc) containing tricalcium phosphate putty scaffold material (TCP-P) and of a particulate tricalcium phosphate (TCP-G) graft on bone formation, volume stability and osteogenic marker expression in biopsies sampled 6 months after bilateral sinus floor augmentation (SFA) in 7 patients applying a split-mouth design. 10% autogenous bone chips were added to the grafting material during surgery. The grain size of the TCP granules was 700 to 1400 µm for TCP-G and 125 to 250 µm and 500 to 700 µm (ratio 1:1) for TCP-P...
July 29, 2017: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/28757934/applications-of-biomaterials-for-bone-augmentation-of-jaws-clinical-outcomes-and-in-vitro-studies
#19
L Tettamanti, M Andreasi Bassi, G Trapella, V Candotto, A Tagliabue
Partially or totally edentulous jaws frequently undergoes from moderate to severe bone atrophy with problems of prosthetic rehabilitation. The inability to make a prosthetic rehabilitation on implants may led to the use of a partial or total removable denture with difficulties in eating and speech, ulcerations of the oral mucosa and loss of facial vertical dimension. These problems may be solved performing bone augmentation procedures. Bone grafts and distraction osteogenesis brought implant dentistry from an experimental practice to become a consolidate dental procedure...
January 2017: Oral & Implantology
https://www.readbyqxmd.com/read/28753925/pilot-study-using-a-chitosan-hydroxyapatite-implant-for-guided-alveolar-bone-growth-in-patients-with-chronic-periodontitis
#20
Fabiola Vaca-Cornejo, Héctor Macías Reyes, Sergio H Dueñas Jiménez, Ricardo A Llamas Velázquez, Judith M Dueñas Jiménez
Periodontitis is an infectious and inflammatory disease associated with significant loss of alveolar crest and soft tissue attached to the teeth. Chitosan and hydroxyapatite are biomaterials used for bone tissue repair because of their biodegradability and biocompatibility in nature. The present study evaluated the effects of chitosan (CH) in combination with hydroxyapatite (HAP) to promote alveolar bone growth. A chitosan implant mixed with hydroxyapatite was implanted into the affected area of 9 patients suffering chronic periodontitis...
July 19, 2017: Journal of Functional Biomaterials
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