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Dental Biomaterials

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https://www.readbyqxmd.com/read/28218482/osteoblastic-differentiation-of-periodontal-ligament-stem-cells-on-non-stoichiometric-calcium-phosphate-and-titanium-surfaces
#1
L Winning, L Robinson, A R Boyd, I A El Karim, F T Lundy, B J Meenan
Bioactive materials offer particular clinical benefits in the field of dental implantology, where differentiation of stem cells towards an osteoblastic lineage is required for osseointegration and appropriate function of implants in vivo. The aim of this study was to evaluate the osteoblastic response of Stro-1+ve periodontal ligament stem cells (PDLSCs) to three well-characterised biomaterial surfaces: an abraded titanium surface (cpTi) control; a polycrystalline titanium surface, with both micro and nano-topography produced by radio frequency magnetron sputtering (TiTi); and the same surface incorporating a sputter deposited calcium phosphate coating (CaP-TiTi)...
February 20, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28215503/biomaterial-shell-bending-with-3d-printed-templates-in-vertical-and-alveolar-ridge-augmentation-a-technical-note
#2
Florian G Draenert, Florian Gebhart, Gergo Mitov, Andreas Neff
OBJECTIVES: Alveolar ridge and vertical augmentations are challenging procedures in dental implantology. Even material blocks with an interconnecting porous system are never completely resorbed. Shell techniques combined with autologous bone chips are therefore the gold standard. Using biopolymers for these techniques is well documented. We applied three-dimensional (3-D) techniques to create an individualized bending model for the adjustment of a plane biopolymer membrane made of polylactide...
January 4, 2017: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/28207942/effect-of-ridge-preservation-for-early-implant-placement-is-there-a-need-to-remove-the-biomaterial
#3
Daniel S Thoma, Nadja Naenni, Goran I Benic, Fernando Munoz, Christoph H F Hämmerle, Ronald E Jung
AIM: to assess i) bone regeneration around implants placed early in sites with or without ridge preservation and i) if the bone substitute material (DBBM-C) has to be removed at implant placement MATERIALS AND METHODS: In eight beagle dogs, three sites were randomly assigned to ridge preservation (DBBM-C plus collagen matrix (CMX)) (two sites; RP) or spontaneous healing (1 site; SH). Four weeks later, in one of the RP sites, dental implants were placed without removing the DBBM-C (RP1), whereas in RP2 and SH sites all non-integrated DBBM-C and/or granulation tissue was removed before implant placement and concomitant GBR...
February 16, 2017: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/28199081/correction-to-a-mesoporous-silica-biomaterial-for-dental-biomimetic-crystallization
#4
Yu-Chih Chiang, Hong-Ping Lin, Hao-Hueng Chang, Ya-Wen Cheng, Hsin-Yen Tang, Wei-Ching Yen, Po-Yen Lin, Kei-Wen Chang, Chun-Pin Lin
No abstract text is available yet for this article.
February 15, 2017: ACS Nano
https://www.readbyqxmd.com/read/28160669/effect-of-sex-hormone-levels-sex-body-mass-index-and-other-host-factors-on-human-craniofacial-bone-regeneration-with-bioactive-tricalcium-phosphate-grafts
#5
Christine Knabe, Aynur Mele, Peter Herbert Kann, Barbara Peleska, Doaa Adel-Khattab, Harald Renz, Alexander Reuss, Marc Bohner, Michael Stiller
Little is known regarding the associations between sex-hormone levels, sex, body mass index (BMI), age, other host factors and biomaterial stimulated bone regeneration in the human craniofacial skeleton. The aim of this study was to elucidate the associations between these factors and bone formation after sinus floor augmentation procedures (SFA) utilizing a bioactive tricalcium phosphate (TCP) bone grafting material. We conducted a prospective study in a human population in which 60 male and 60 female participants underwent SFA and dental implant placement using a staged approach...
January 28, 2017: Biomaterials
https://www.readbyqxmd.com/read/28157689/differential-mineralization-of-human-dental-pulp-stem-cells-on-diverse-polymers
#6
Christian Apel, Patricia Buttler, Jochen Salber, Anandhan Dhanasingh, Sabine Neuss
In tissue engineering, biomaterials are used as scaffolds for spatial distribution of specific cell types. Biomaterials can potentially influence cell proliferation and extracellular matrix formation, both in positive and negative ways. The aim of the present study was to investigate and compare mineralized matrix production of human dental pulp stem cells (DPSC), cultured on 17 different well-characterized polymers. Osteogenic differentiation of DPSC was induced for 21 days on biomaterials using dexamethasone, L-ascorbic-acid-2-phosphate, and sodium β-glycerophosphate...
February 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28149193/sheep-as-an-experimental-model-for-biomaterial-implant-evaluation
#7
Suelen Cristina Sartoretto, Marcelo José Uzeda, Fúlvio Borges Miguel, Jhonathan Raphaell Nascimento, Fabio Ascoli, Mônica Diuana Calasans-Maia
OBJECTIVE: Based on a literature review and on our own experience, this study proposes sheep as an experimental model to evaluate the bioactive capacity of bone substitute biomaterials, dental implant systems and orthopedics devices. The literature review covered relevant databases available on the Internet from 1990 until to date, and was supplemented by our own experience. METHODS: For its resemblance in size and weight to humans, sheep are quite suitable for use as an experimental model...
September 2016: Acta Ortopedica Brasileira
https://www.readbyqxmd.com/read/28127534/incorporation-of-silver-nanoparticles-on-the-surface-of-orthodontic-microimplants-to-achieve-antimicrobial-properties
#8
Adith Venugopal, Nallal Muthuchamy, Harsh Tejani, Anantha-Iyengar Gopalan, Kwang-Pill Lee, Heon-Jin Lee, Hee Moon Kyung
OBJECTIVE: Microbial aggregation around dental implants can lead to loss/loosening of the implants. This study was aimed at surface treating titanium microimplants with silver nanoparticles (AgNPs) to achieve antibacterial properties. METHODS: AgNP-modified titanium microimplants (Ti-nAg) were prepared using two methods. The first method involved coating the microimplants with regular AgNPs (Ti-AgNP) and the second involved coating them with a AgNP-coated biopolymer (Ti-BP-AgNP)...
January 2017: Korean Journal of Orthodontics
https://www.readbyqxmd.com/read/28110070/mesoscale-porosity-at-the-dentin-enamel-junction-could-affect-the-biomechanical-properties-of-teeth
#9
Elsa Vennat, Wenlong Wang, Rachel Genthial, Bertrand David, Elisabeth Dursun, Aurélien Gourrier
In this paper, the 3D-morphology of the porosity in dentin is investigated within the first 350μm from the dentin-enamel junction (DEJ) by fluorescence confocal laser scanning microscopy (CLSM). We found that the porous microstructure exhibits a much more complex geometry than classically described, which may impact our fundamental understanding of the mechanical behavior of teeth and could have practical consequences for dental surgery. Our 3D observations reveal numerous fine branches stemming from the tubules which may play a role in cellular communication or mechanosensing during the early stages of dentinogenesis...
January 19, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28109162/odontoblastic-differentiation-of-dental-pulp-stem-cells-from-healthy-and-carious-teeth-on-an-original-pcl-based-3d-scaffold
#10
A Louvrier, E Euvrard, L Nicod, G Rolin, F Gindraux, L Pazart, C Houdayer, P Y Risold, F Meyer, C Meyer
AIMS: To isolate and characterize Dental Pulp Stem Cells (DPSCs) obtained from carious and healthy mature teeth extracted when conservative treatment was not possible or for orthodontic reasons; to evaluate the ability of DPSCs to colonize, proliferate, and differentiate into functional odontoblast-like cells when cultured onto a polycaprolactone cone made by jet-spraying and prototyped into a design similar to a gutta-percha cone. METHODOLOGY: DPSCs were obtained from 9 carious and 12 healthy mature teeth...
January 21, 2017: International Endodontic Journal
https://www.readbyqxmd.com/read/28087075/cellular-transcriptional-response-to-zirconia-based-implant-materials
#11
Brigitte Altmann, Kerstin Rabel, Ralf J Kohal, Susanne Proksch, Pascal Tomakidi, Erik Adolfsson, Falk Bernsmann, Paola Palmero, Tobias Fürderer, Thorsten Steinberg
OBJECTIVE: To adequately address clinically important issues such as osseointegration and soft tissue integration, we screened for the direct biological cell response by culturing human osteoblasts and gingival fibroblasts on novel zirconia-based dental implant biomaterials and subjecting them to transcriptional analysis. METHODS: Biomaterials used for osteoblasts involved micro-roughened surfaces made of a new type of ceria-stabilized zirconia composite with two different topographies, zirconium dioxide, and yttria-stabilized zirconia (control)...
January 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28081293/role-of-pyridoxal-5-phosphate-at-the-titanium-implant-interface-in-vivo-increased-hemophilicity-inactive-platelet-adhesion-and-osteointegration
#12
Jung Seung Lee, Kyuri Kim, Joseph P Park, Seung-Woo Cho, Haeshin Lee
Titanium is the most biocompatible inorganic biomaterial with a long history of use in orthopedic and dental implants. However, promoting rapid and effective bone formation and integration onto etched, rough TiO2 surfaces has been a challenging topic. Here, 21 commercially available molecules are examined that met the following criteria: (1) contain phosphonic acid for stable immobilization onto TiO2 surfaces and (2) have a molecular weight less than 500 Da for negligible coating thickness. Of these molecules, the surface immobilization of pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 , dramatically increases the hemophilic property of the surface and accelerated osteointegration in vivo...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28070691/biological-characteristic-effects-of-human-dental-pulp-stem-cells-on-poly-%C3%AE%C2%B5-caprolactone-biphasic-calcium-phosphate-fabricated-scaffolds-using-modified-melt-stretching-and-multilayer-deposition
#13
Natkrita Wongsupa, Thongchai Nuntanaranont, Suttatip Kamolmattayakul, Nuttawut Thuaksuban
Craniofacial bone defects such as alveolar cleft affect the esthetics and functions that need bone reconstruction. The advanced techniques of biomaterials combined with stem cells have been a challenging role for maxillofacial surgeons and scientists. PCL-coated biphasic calcium phosphate (PCL-BCP) scaffolds were created with the modified melt stretching and multilayer deposition (mMSMD) technique and merged with human dental pulp stem cells (hDPSCs) to fulfill the component of tissue engineering for bone substitution...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28067359/antibacterial-properties-of-nanostructured-cu-tio2-surfaces-for-dental-implants
#14
Jonathan Rosenbaum, Davy Louis Versace, Samir Abbad-Andallousi, Remi Pires, Christophe Azevedo, Pierre Cénédese, Pierre Dubot
The influence of copper derived TiO2 surfaces (nCu-nT-TiO2) on the death of nosocomial Staphylococcus aureus (Sa) and Escherichia coli (Ec), was investigated. TiO2 nanotube (nT-TiO2) arrays were fabricated by anodic oxidation of pure titanium sheets in fluorhydric solutions, leading to surface nanostructuration and creation of specific reactive sites. Copper nanocubes with a mean size of 20 nm have been synthesized and deposited on the nT-TiO2 surface by pulsed electrodeposition from a copper sulphate solution...
January 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28050314/biocompatibility-study-of-lithium-disilicate-and-zirconium-oxide-ceramics-for-esthetic-dental-abutments
#15
Céline Brunot-Gohin, Jean-Luc Duval, Sandra Verbeke, Kayla Belanger, Isabelle Pezron, Gérard Kugel, Dominique Laurent-Maquin, Sophie Gangloff, Christophe Egles
PURPOSE: The increasing demand for esthetically pleasing results has contributed to the use of ceramics for dental implant abutments. The aim of this study was to compare the biological response of epithelial tissue cultivated on lithium disilicate (LS2) and zirconium oxide (ZrO2) ceramics. Understanding the relevant physicochemical and mechanical properties of these ceramics will help identify the optimal material for facilitating gingival wound closure. METHODS: Both biomaterials were prepared with 2 different surface treatments: raw and polished...
December 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28000273/evolution-of-loading-protocols-in-implant-dentistry-for-partially-dentate-arches
#16
REVIEW
Dean Morton, Adrien Pollini
Better outcomes for patients receiving dental implants as part of oral rehabilitation remains a constant goal. Advances in implant design, clinical protocols and biomaterials provide opportunities to accelerate treatment, increasing efficiency, predictability and patient satisfaction. It is important to understand that these changes can result in negative outcomes and increased risk. This article reviews the existing published evidence relating to accelerated clinical protocols and patient outcomes. Subsequent to the review, clinical recommendations are offered...
February 2017: Periodontology 2000
https://www.readbyqxmd.com/read/27987682/porous-magnesium-based-scaffolds-for-tissue-engineering
#17
REVIEW
Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R Boccaccini, Lobat Tayebi
Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987667/effect-of-preconditioning-cobalt-and-nickel-based-dental-alloys-with-bacillus-sp-extract-on-their-surface-physicochemical-properties-and-theoretical-prediction-of-candida-albicans-adhesion
#18
Mounyr Balouiri, Samira Bouhdid, Moulay Sadiki, Wessal Ouedrhiri, Hassan Barkai, Omar El Farricha, Saad Koraichi Ibnsouda, El Houssaine Harki
Biofilm formation on dental biomaterials is implicated in various oral health problems. Thus the challenge is to prevent the formation of this consortium of microorganisms using a safe approach such as antimicrobial and anti-adhesive natural products. Indeed, in the present study, the effects of an antifungal extract of Bacillus sp., isolated from plant rhizosphere, on the surface physicochemical properties of cobalt and nickel based dental alloys were studied using the contact angle measurements. Furthermore, in order to predict the adhesion of Candida albicans to the treated and untreated dental alloys, the total free energy of adhesion was calculated based on the extended Derjaguin-Landau-Verwey-Overbeek approach...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27978808/molecular-cellular-and-pharmaceutical-aspects-of-biomaterials-in-dentistry-and-oral-and-maxillofacial-surgery-an-internationalization-of-higher-education-and-research-perspective
#19
Lidia M Wisniewska, David M Dohan Ehrenfest, Pablo Galindo-Moreno, Jesús Domingo Segovia, Francesco Inchingolo, Hom-Lay Wang, Manuel Fernándes-Cruz
In dentistry and oral and maxillofacial surgery, the development of implantable biomaterials and the understanding of their molecular, cellular and pharmaceutical aspects are currently major fields of research and education, with a considerable impact on the daily clinical practice and the evolution of therapeutic strategies. In the era of globalized economy of knowledge and science, this scientific domain needs the development of global cooperation and a paradigm evolution in the organizational culture of the dental sciences and related dental industry...
December 13, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27941125/histatin-1-enhances-cell-adhesion-to-titanium-in-an-implant-integration-model
#20
I A van Dijk, A F Beker, W Jellema, K Nazmi, G Wu, D Wismeijer, P M Krawczyk, J G M Bolscher, E C I Veerman, J Stap
Cellular adhesion is essential for successful integration of dental implants. Rapid soft tissue integration is important to create a seal around the implant and prevent infections, which commonly cause implant failure and can result in bone loss. In addition, soft tissue management is important to obtain good dental aesthetics. We previously demonstrated that the salivary peptide histatin 1 (Hst1) causes a more than 2-fold increase in the ability of human adherent cells to attach and spread on a glass surface...
December 1, 2016: Journal of Dental Research
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