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Dental Biomaterials

Yingzhi Gu, Yuxing Bai, Dongliang Zhang
The aim of the present study was to construct and compare gelatin-HA-TCP scaffolds with a gelatin-only scaffold and to investigate the effect of the scaffold on osteogenic differentiation of human dental pulp stem cells. We developed a novel scaffold for bone tissue engineering via a solution casting/particle washing method, and the physical and mechanical properties of the scaffolds were examined using scanning electron microscopy and a universal testing machine, respectively. Scaffold cytotoxicity toward hDPSCs was evaluated with the CCK8 method, and hDPSC differentiation was evaluated with an alkaline phosphatase activity assay, alizarin red S staining, and real-time PCR...
March 9, 2018: Journal of Biomedical Materials Research. Part A
Ranran Zhang, Xujie Liu, Zhiyuan Xiong, Qianli Huang, Xing Yang, Hao Yan, Jing Ma, Qingling Feng, Zhijian Shen
Micro/nanostructured TiO2 /ZnO coating has been shown to possess multiple functions, including antibacterial activity and bioactivity. Osteoblast-like SaOS-2 cells were employed for evaluating the in vitro osteogenic capacity of this coating and positive results were obtained. However, traditional principles of osseointegration focus only on the osteogenic differentiation alone. The effects of immunomodulation on the osteogenic activity have been largely ignored. In this study, the inflammatory responses of macrophages on the micro/nanostructured TiO2 /ZnO coating were investigated...
March 8, 2018: Artificial Cells, Nanomedicine, and Biotechnology
Pinar Ercal, Gorke Gurel Pekozer, Gamze Torun Kose
The treatment of bone that is impaired due to disease, trauma or tumor resection creates a challenge for both clinicians and researchers. Critical size bone defects are conventionally treated with autografts which are associated with risks such as donor site morbidity and limitations like donor shortage. Bone tissue engineering has become a promising area for the management of critical size bone defects by the employment of biocompatible materials and the discovery of novel stem cell sources. Mesenchymal stem cells (MSCs) can be isolated with ease from various dental tissues including dental pulp stem cells, stem cells from apical papilla, dental follicle stem cells, stem cells from human exfoliated deciduous teeth, periodontal ligament stem cells, gingival stem cells and tooth germ derived stem cells...
March 2, 2018: Advances in Experimental Medicine and Biology
Bo Huang, Walter Siqueira, Dennis G Cvitkovitch, Yoav Finer
OBJECTIVES: To identify and characterize specific esterases from S. mutans with degradative activity toward methacrylate-based resin monomers. METHODS: Out of several putative esterases, an esterase encoded in an Open Reading Frame as SMU_118c (The National Center for Biotechnology Information, NCBI), was found to have true hydrolase activities. SMU_118c was cloned, expressed, purified and further characterized for its respective hydrolytic activity towards ester-containing nitrophenyl substrates and the universal resin monomers bis-phenyl-glycidyl-dimethacrylate (bisGMA) and triethyleneglycol dimethacrylate (TEGDMA) at neutral (7...
February 26, 2018: Acta Biomaterialia
Peter Fairbairn, Minas Leventis, Chas Mangham, Robert Horowitz
This case report highlights the use of a novel in situ hardening synthetic (alloplastic), resorbable, bone grafting material composed of beta tricalcium phosphate and calcium sulfate, for alveolar ridge preservation. A 35-year-old female patient was referred by her general dentist for extraction of the mandibular right first molar and rehabilitation of the site with a dental implant. The nonrestorable tooth was "atraumatically" extracted without raising a flap, and the socket was immediately grafted with the synthetic biomaterial and covered with a hemostatic fleece...
2018: Case Reports in Dentistry
A D Anastasiou, S Strafford, C L Thomson, J Gardy, T J Edwards, M Malinowski, S A Hussain, N K Metzger, A Hassanpour, C T A Brown, A P Brown, M S Duggal, A Jha
A radical new methodology for the exogenous mineralization of hard tissues is demonstrated in the context of laser-biomaterials interaction. The proposed approach is based on the use of femtosecond pulsed lasers (fs) and Fe3+ -doped calcium phosphate minerals (specifically in this work fluorapatite powder containing Fe2 O3 nanoparticles (NP)). A layer of the synthetic powder is applied to the surface of eroded bovine enamel and is irradiated with a fs laser (1040 nm wavelength, 1 GHz repetition rate, 150 fs pulse duration and 0...
February 17, 2018: Acta Biomaterialia
R B Price, J L Ferracane
No abstract text is available yet for this article.
February 1, 2018: Journal of Dental Research
Fan Liang, Hyuma Leland, Breanna Jedrzejewski, Allyn Auslander, Seija Maniskas, Jordan Swanson, Mark Urata, Jeffrey Hammoudeh, William Magee
Alveolar cleft reconstruction has historically relied on autologous iliac crest bone grafting (ICBG), but donor site morbidity, pain, and prolonged hospitalization have prompted the search for bone graft substitutes. The authors evaluated bone graft substitutes with the highest levels of evidence, and highlight the products that show promise in alveolar cleft repair and in maxillary augmentation. This comprehensive review guides the craniofacial surgeon toward safe and informed utilization of biomaterials in the alveolar cleft...
February 14, 2018: Journal of Craniofacial Surgery
José Luis Calvo Guirado, Pilar Cegarra Del Pino, Lari Sapoznikov, Rafael Arcesio Delgado Ruíz, Manuel Fernández Dominguez, Sérgio Alexandre Gehrke
OBJECTIVES: To investigate freshly extracted dental particulate used to graft post-extraction sockets in dogs, comparing new bone formation at experimental and control sites. MATERIAL AND METHODS: Bilateral premolars P2, P3, P4 and first mandibular molars were extracted atraumatically from six American Fox Hound dogs. The teeth were ground immediately using a 'Smart Dentin Grinder.' The dentin particulate was sieved to ensure a grain size of 300-1200μm and immersed in an alcohol cleanser to dissolve organic debris and bacteria, followed by washing in sterile saline buffer solution...
February 15, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
Li Yao, Nikol Flynn
BACKGROUND CONTEXT: Advances in the development of biomaterials and stem cell therapy provide a promising approach to regenerating degenerated discs. The normal nucleus pulposus (NP) cells exhibit the similar phenotype as chondrocytes. Because dental pulp stem cells (DPSCs) can be differentiated into chondrogenic cells, the DPSCs and DPSCs-derived chondrogenic cells encapsulated in type I and type II collagen hydrogels can potentially be transplanted into degenerated nucleus pulposus (NP) to repair damaged tissue...
February 13, 2018: Spine Journal: Official Journal of the North American Spine Society
Eduardo Anitua, María Troya, Mar Zalduendo
The field of tissue engineering is emerging as a multidisciplinary area with promising potential for regenerating new tissues and organs. This approach requires the involvement of three essential components: stem cells, scaffolds and growth factors. To date, dental pulp stem cells have received special attention because they represent a readily accessible source of stem cells. Their high plasticity and multipotential capacity to differentiate into a large array of tissues can be explained by its neural crest origin, which supports applications beyond the scope of oral tissues...
February 12, 2018: Cytotherapy
P Bargavi, S Chitra, D Durgalakshmi, P Rajashree, S Balakumar
Bioglass 45S5 (45% SiO2-24.5% NaO-24.5% CaO-6% P2O5) is a unique bioactive material, which is being used for bone and dental substitution. This system has been highly preferred for its osteoconductive and osteoinductive performance. Despite its attractive bioactivity, there are limitations in using this material for orthopedic and dental applications due to its poor processability and mechanical strength. To improve the load-sharing and stress distribution, TiO2 nanoparticles have been introduced into the nanoBioglass (nBG) by sol-gel method...
July 1, 2018: Journal of Nanoscience and Nanotechnology
Amber A Miller, Koyo Takimoto, James Wealleans, Anibal Diogenes
INTRODUCTION: There is a complex interaction between biomaterials placed as a coronal barrier with stem cells and dentin in regenerative procedures. In this study, the effect of Biodentine (BD; Septodont, Saint-Maurdes-Fossés, France), Endosequence BC Root Repair Material-Putty (ES; Brasseler, Savannah, GA), Endosequence BC Root Repair Material-Putty Fast set (ES-fast, Brasseler), and ProRoot (Dentsply Tulsa Dental Specialties, Johnson City, TN) mineral trioxide aggregate (MTA) on the viability and differentiation of stem cells of the apical papilla (SCAP) was evaluated using an ex vivo dentin disk model...
February 6, 2018: Journal of Endodontics
Rafał Pokrowiecki, Krzysztof Pałka, Agnieszka Mielczarek
AIM: The studies on tooth structure provided basis for nanotechnology-based dental treatment approaches known as nanodentistry which aims at detection and treatment of oral pathologies, such as dental caries and periodontal diseases, insufficiently being treated by conventional materials or drugs. This review aims at defining the role of nanodentistry in the medical area, its potential and hazards. MATERIALS & METHODS: To validate these issues, current literature on nanomaterials for dental applications was critically reviewed...
February 8, 2018: Nanomedicine
Alethea Liens, Aurélien Etiemble, Pascaline Rivory, Sandra Balvay, Jean-Marc Pelletier, Sandrine Cardinal, Damien Fabrègue, Hidemi Kato, Philippe Steyer, Tais Munhoz, Jerome Adrien, Nicolas Courtois, Daniel J Hartmann, Jérôme Chevalier
Ti40Zr10Cu36Pd14 Bulk Metallic Glass (BMG) appears very attractive for future biomedical applications thanks to its high glass forming ability, the absence of toxic elements such as Ni, Al or Be and its good mechanical properties. For the first time, a complete and exhaustive characterization of a unique batch of this glassy alloy was performed, together with ISO standard mechanical tests on machined implant-abutment assemblies. The results were compared to the benchmark Ti-6Al-4V ELI (Extra-Low-Interstitial) to assess its potential in dental implantology...
February 6, 2018: Materials
Xi Liu, Liying Peng, Jingxin Meng, Zhongpeng Zhu, Bing Han, Shutao Wang
Biomedical materials, such as orthopedic biomaterials, have a great impact on improving life quality and self-esteem of human beings. However, the usage of fixed appliances during dental treatment often increases the difficulty of oral cleaning and enlarges the adhesion opportunity of oral bacteria. Furthermore, the existing anti-adhesion coatings, such as polyethylene glycol derivatives and zwitterionic polymers, have not been universally accepted in the oral environment due to their intrinsic problems. Herein, inspired by the anti-adhesion capability of bovine serum albumin, we report a facile protein-based anti-bacterial surface, showing excellent anti-adhesion performance toward oral bacteria...
January 26, 2018: Nanoscale
Ludwig Stanislas Loison-Robert, Mathilde Tassin, Eric Bonte, Tsouria Berbar, Juliane Isaac, Ariane Berdal, Stéphane Simon, Benjamin P J Fournier
BACKGROUND: Calcium silicate-based cements are biomaterials with calcium oxide and carbonate filler additives. Their properties are close to those of dentin, making them useful in restorative dentistry and endodontics. The aim of this study was to evaluate the in vitro biological effects of two such calcium silicate cements, Biodentine (BD) and Bioroot (BR), on dental stem cells in both direct and indirect contact models. The two models used aimed to mimic reparative dentin formation (direct contact) and reactionary dentin formation (indirect contact)...
2018: PloS One
André Boziki Xavier do Carmo, Suelen Cristina Sartoretto, Adriana Terezinha Neves Novellino Alves, José Mauro Granjeiro, Fúlvio Borges Miguel, Jose Calasans-Maia, Monica Diuana Calasans-Maia
This study aimed to evaluate bone repair in rat dental sockets after implanting nanostructured carbonated hydroxyapatite/sodium alginate (CHA) and nanostructured carbonated hydroxyapatite/sodium alginate containing 5% strontium microspheres (SrCHA) as bone substitute materials. Twenty male Wistar rats were randomly divided into two experimental groups: CHA and SrCHA (n=5/period/group). After one and 6 weeks of extraction of the right maxillary central incisor and biomaterial implantation, 5 μm bone blocks were obtained for histomorphometric evaluation...
January 18, 2018: Journal of Applied Oral Science: Revista FOB
Cameron A Stewart, Yoav Finer, Benjamin D Hatton
Antimicrobial drug release from biomaterials for orthopedic repair and dental restorations can prevent biofilm growth and caries formation. Carriers for drug incorporation would benefit from long-term drug storage, controlled release, and structural stability. Mesoporous silica, synthesized through a co-assembly of silica and surfactant template, is an ideal drug encapsulation scaffold that maintains structural integrity upon release. However, conventional loading of drug within meso-silica pores via concentration-gradient diffusion limits the overall payload, concentration uniformity, and drug release control...
January 17, 2018: Scientific Reports
Rasika S Phansalkar, Joo-Won Nam, Shao-Nong Chen, James B McAlpine, Ariene A Leme, Berdan Aydin, Ana-Karina Bedran-Russo, Guido F Pauli
Proanthocyanidins (PACs) find wide applications for human use including food, cosmetics, dietary supplements, and pharmaceuticals. The chemical complexity associated with PACs has triggered the development of various chromatographic techniques, with countercurrent separation (CCS) gaining in popularity. This study applied the recently developed DESIGNER (Depletion and Enrichment of Select Ingredients Generating Normalized Extract Resources) approach for the selective enrichment of trimeric and tetrameric PACs using centrifugal partition chromatography (CPC)...
December 21, 2017: Journal of Chromatography. A
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