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Dental Biomaterials

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https://www.readbyqxmd.com/read/28527850/complement-activation-by-pulp-capping-materials-plays-a-significant-role-in-both-inflammatory-and-pulp-stem-cells-recruitment
#1
Thomas Giraud, Pierre Rufas, Fanny Chmilewsky, Charlotte Rombouts, Jacques Dejou, Charlotte Jeanneau, Imad About
INTRODUCTION: The role of complement, especially through the C5a fragment, is well-known for the initiation of inflammation. Its involvement in regeneration has been shown more recently by the recruitment of mesenchymal stem cells. C5a can be produced locally by the pulp fibroblasts in response to injury or infection. This work aims to investigate the effect of different pulp capping biomaterials on complement activation and its possible influence on inflammatory and pulp stem cell recruitment...
May 17, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28526091/a-pre-therapeutic-coating-for-medical-devices-that-prevents-the-attachment-of-candida-albicans
#2
Diego Vargas-Blanco, Aung Lynn, Jonah Rosch, Rony Noreldin, Anthony Salerni, Christopher Lambert, Reeta P Rao
BACKGROUND: Hospital acquired fungal infections are defined as "never events"-medical errors that should never have happened. Systemic Candida albicans infections results in 30-50% mortality rates. Typically, adhesion to abiotic medical devices and implants initiates such infections. Efficient adhesion initiates formation of aggressive biofilms that are difficult to treat. Therefore, inhibitors of adhesion are important for drug development and likely to have a broad spectrum efficacy against many fungal pathogens...
May 19, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28513133/antibacterial-property-of-a-polyethylene-glycol-grafted-dental-material
#3
Liying Peng, Li Chang, Xi Liu, Jiuxiang Lin, Hongliang Liu, Bing Han, Shutao Wang
Dental materials often cause bacterial adhesion and promote bacterial biofilm formation, which brings a series of long-standing and significant problems in oral health. However, the current development of antibacterial research in dental devices is limited by the lack of materials endowed with good antibacterial properties against oral bacteria. Here, we present a new strategy for reducing the initial adhesion of bacterial on dental biomaterials by chemically bonding long-chain polyethylene glycol. Our work represents an important step toward solving the problem of bacterial accumulation on dental devices...
May 17, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28512498/treatment-outcomes-of-full-pulpotomy-as-an-alternative-to-tooth-extraction-in-molars-with-hyperplastic-irreversible-pulpitis-a-case-report
#4
Saeed Asgary, Prashant Verma, Ali Nosrat
Root canal therapy (RCT) is a common and successful treatment for irreversible pulpitis due to carious pulp exposure in mature permanent teeth. However, it is often an expensive procedure, may require multiple appointments, and requires a high level of training and clinical skill, specifically in molars. Uninsured patients, low-income patients, and patients with limited access to specialist care often elect for extraction of restorable teeth with irreversible pulpitis. There is a need for an alternative affordable treatment option to preserve their teeth and maintain chewing function...
2017: Iranian Endodontic Journal
https://www.readbyqxmd.com/read/28501354/calcium-orthophosphates-capo4-occurrence-and-properties
#5
REVIEW
S V Dorozhkin
The present overview is intended to point the readers' attention to the important subject of calcium orthophosphates (CaPO4). This type of materials is of the special significance for the human beings because they represent the inorganic part of major normal (bones, teeth and antlers) and pathological (those appearing due to various diseases) calcified tissues of mammals. For example, atherosclerosis results in blood vessel blockage caused by a solid composite of cholesterol with CaPO4, while dental caries (tooth decay) and osteoporosis (a low bone mass with microarchitectural changes) mean a partial decalcification of teeth and bones, respectively, that results in replacement of a less soluble and harder biological apatite by more soluble and softer calcium hydrogenorthophosphates...
May 10, 2017: Morphologie: Bulletin de L'Association des Anatomistes
https://www.readbyqxmd.com/read/28499630/effect-of-surface-alkali-based-treatment-of-titanium-implants-on-ability-to-promote-in-vitro-mineralization-and-in-vivo-bone-formation
#6
Winston A Camargo, Shinji Takemoto, Jan Willem Hoekstra, Sander C G Leeuwenburgh, John A Jansen, Jeroen J J P van den Beucken, Hamdan S Alghamdi
This study investigated whether a novel alkali-based surface modification enhances in-vitro mineralization as well as in-vivo bone formation around titanium (Ti) implants in a femoral condyle model of 36 male Wister rats. All implant surfaces were grit-blasted and then received either acid-etching treatment, alkali-based treatment, or were left untreated (controls). Histological and histomorphometrical analyses were performed on retrieved specimens after 4 and 8 weeks of healing to assess peri-implant bone formation...
May 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28495017/graphene-for-the-development-of-the-next-generation-of-biocomposites-for-dental-and-medical-applications
#7
REVIEW
Han Xie, Tong Cao, Francisco Javier Rodríguez-Lozano, Emma Kim Luong-Van, Vinicius Rosa
OBJECTIVE: Graphene and its derivatives, graphene oxide (GO) and reduced graphene oxide (rGO), are 2D carbon-based materials with remarkable physical, chemical and biological properties. Graphene sheets have high specific surface area and mechanical strength. Moreover, they have been shown to influence the differentiation of stem cells and to improve properties of biomaterials. METHODS: Here, we present the recent achievements on the use of graphene and its derivatives to improve properties and enhance bioactivity of biomaterials...
May 8, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28492746/biocompatibility-of-a-new-dental-glass-ionomer-cement-with-cellulose-microfibers-and-cellulose-nanocrystals
#8
Rafael Menezes-Silva, Fabiano Vargas Pereira, Maria Helena Santos, Janir Alves Soares, Suelleng Maria Cunha Santos Soares, João Luiz de Miranda
Developing new restorative materials should avoid damage to tissue structures. This study evaluated the biocompatibility of a commercial dental glass ionomer cement (GIC) mechanically reinforced with cellulose microfibers (GIC+CM) or cellulose nanocrystals (GIC+CN) by implantation of three test specimens in subcutaneous tissue in the dorsal region of 15 Rattus norvegicus albinus rats. Each rat received one specimen of each cement, resulting in the following groups (n=15): Group GIC (Control), Group GIC+CM and Group GIC+NC...
March 2017: Brazilian Dental Journal
https://www.readbyqxmd.com/read/28482616/hydroxyapatite-bioceramic-with-large-porosity
#9
M Mbarki, P Sharrock, M Fiallo, H ElFeki
Calcium phosphate based biomaterials have been used as bone graft with great success in the last decade. This material is employed in orthopedic and dental applications depending on their specific properties. In this work, we made a bioceramic with a large porosity, then we measured porosity, density and compressive strength of HA bioceramic. The SEM analysis was performed to show the morphology of the structure. The mechanical properties depend on the sintering of the HA bioceramic and the amount of pores...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28482471/comparison-of-the-osteogenic-adipogenic-chondrogenic-and-cementogenic-differentiation-potential-of-periodontal-ligament-cells-cultured-on-different-biomaterials
#10
C C Barrera-Ortega, L Hoz-Rodríguez, H Arzate, A Fonseca-García, J Pérez-Alvarez, S E Rodil
It has been shown that the cellular responses such as adhesion, proliferation and differentiation are influenced by the surface properties, such as the topography or the surface energy. However, less is known about the effect of the chemical composition and type of material on the differentiation potential. The objective of the present paper is to compare the differentiation potential of periodontal ligament cells (HPLC) into adipocytes, osteoblasts, chondroblasts and cementoblasts of three type of materials (metals, ceramics and polymers) without using any biological induction media, but keeping the average roughness values within a limited range of 2...
July 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28474322/%C3%AE-tcp-ha-with-or-without-enamel-matrix-proteins-for-maxillary-sinus-floor-augmentation-a-histomorphometric-analysis-of-human-biopsies
#11
James Carlos Nery, Luís Antônio Violin Dias Pereira, George Furtado Guimarães, Cassio Rocha Scardueli, Fabiana Mantovani Gomes França, Rubens Spin-Neto, Andreas Stavropoulos
BACKGROUND: It is still unclear whether enamel matrix proteins (EMD) as adjunct to bone grafting enhance bone healing. This study compared histomorphometrically maxillary sinus floor augmentation (MSFA) with β-TCP/HA in combination with or without EMD in humans. METHODS: In ten systemically healthy patients needing bilateral MSFA, one side was randomly treated using β-TCP/HA mixed with EMD (BC + EMD) and the other side using only β-TCP/HA (BC). After 6 months, biopsies were harvested from grafted areas during implant installation, being histologically and histomorphometrically analyzed...
December 2017: International Journal of Implant Dentistry
https://www.readbyqxmd.com/read/28456657/topography-of-calcium-phosphate-ceramics-regulates-primary-cilia-length-and-tgf-receptor-recruitment-associated-with-osteogenesis
#12
Jingwei Zhang, Melis Dalbay, Xiaoman Luo, Erik Vrij, Davide Barbieri, Lorenzo Moroni, Joost D de Bruijn, Clemens A van Blitterswijk, Paul Chapple, Martin M Knight, Huipin Yuan
The surface topography of synthetic biomaterials is known to play a role in material-driven osteogenesis. Recent studies show that TGFβ signaling also initiates osteogenic differentiation. TGFβ signaling requires the recruitment of TGFβ receptors (TGFβR) to the primary cilia. In this study, we hypothesize that the surface topography of calcium phosphate ceramics regulates stem cell morphology, primary cilia structure and TGFβR recruitment to the cilium associated with osteogenic differentiation. We developed a 2D system using two types of tricalcium phosphate (TCP) ceramic discs with identical chemistry...
April 26, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28447119/maxillary-sinus-lift-with-beta-tricalcium-phosphate-%C3%AE-tcp-in-edentulous-patients-a-nanotomographic-and-raman-study
#13
Florence Pascaretti-Grizon, Bernard Guillaume, Lisa Terranova, Baptiste Arbez, Hélène Libouban, Daniel Chappard
Sinus lift elevation restores bone mass at the maxilla in edentulate patients before the placement of dental implants. It consists of opening the lateral side of the sinus and grafting beta-tricalcium phosphate granules (β-TCP) under the olfactory membrane. Bone biopsies were obtained in five patients after 60 weeks. They were embedded undecalcified in poly(methyl methacrylate) (pMMA); blocks were analyzed by nanocomputed tomography (nanoCT); specific areas were studied by Raman microspectroscopy. Remnants of β-TCP were osseointegrated and covered with mineralized bone; osteoid tissue was also filling the inner porosity...
April 26, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28430345/healing-response-of-rat-pulp-treated-with-an-injectable-keratin-hydrogel
#14
Lavanya Ajay Sharma, Robert M Love, Mohammad A Ali, Ajay Sharma, Soraia Macari, Avadhoot Avadhani, George J Dias
BACKGROUND: Keratin has shown promising outcomes as a biomaterial due to its inherent bioactivity, biocompatibility and regenerative effects. The effect of keratin on repair and regeneration of dental tissues has never been studied before. Current therapies to treat pulp tissues involve its replacement with inert, synthetic materials that do not have a proper biological function, leading to failure and tooth loss. This study aimed to develop a biocompatible keratin hydrogel (KH) suitable for pulp therapies...
April 20, 2017: Journal of Applied Biomaterials & Functional Materials
https://www.readbyqxmd.com/read/28427322/dental-pulp-pluripotent-like-stem-cells-dppsc-a-new-stem-cell-population-with-chromosomal-stability-and-osteogenic-capacity-for-biomaterials-evaluation
#15
Raquel Núñez-Toldrà, Ester Martínez-Sarrà, Carlos Gil-Recio, Miguel Ángel Carrasco, Ashraf Al Madhoun, Sheyla Montori, Maher Atari
BACKGROUND: Biomaterials are widely used to regenerate or substitute bone tissue. In order to evaluate their potential use for clinical applications, these need to be tested and evaluated in vitro with cell culture models. Frequently, immortalized osteoblastic cell lines are used in these studies. However, their uncontrolled proliferation rate, phenotypic changes or aberrations in mitotic processes limits their use in long-term investigations. Recently, we described a new pluripotent-like subpopulation of dental pulp stem cells derived from the third molars (DPPSC) that shows genetic stability and shares some pluripotent characteristics with embryonic stem cells...
April 21, 2017: BMC Cell Biology
https://www.readbyqxmd.com/read/28416222/dentin-on-the-nanoscale-hierarchical-organization-mechanical-behavior-and-bioinspired-engineering
#16
REVIEW
Luiz E Bertassoni
OBJECTIVE: Knowledge of the structural organization and mechanical properties of dentin has expanded considerably during the past two decades, especially on a nanometer scale. In this paper, we review the recent literature on the nanostructural and nanomechanical properties of dentin, with special emphasis in its hierarchical organization. METHODS: We give particular attention to the recent literature concerning the structural and mechanical influence of collagen intrafibrillar and extrafibrillar mineral in healthy and remineralized tissues...
April 14, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28415544/%C3%AE-pyrophosphate-a-potential-biomaterial-for-dental-applications
#17
A D Anastasiou, S Strafford, O Posada-Estefan, C L Thomson, S A Hussain, T J Edwards, M Malinowski, N Hondow, N K Metzger, C T A Brown, M N Routledge, A P Brown, M S Duggal, A Jha
Tooth hypersensitivity is a growing problem affecting both the young and ageing population worldwide. Since an effective and permanent solution is not yet available, we propose a new methodology for the restoration of dental enamel using femtosecond lasers and novel calcium phosphate biomaterials. During this procedure the irradiated mineral transforms into a densified layer of acid resistant iron doped β-pyrophosphate, bonded with the surface of eroded enamel. Our aim therefore is to evaluate this densified mineral as a potential replacement material for dental hard tissue...
June 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28408957/development-of-technique-for-in-vitro-embryotoxicity-of-dental-biomaterials
#18
REVIEW
Koichi Imai
The Embryonic Stem Cell Test (EST) developed in Germany in 1997 is known as a screening test method capable of predicting the presence of unknown chemicals influencing normal human development. Firstly, we investigated the embryotoxicity of 24 types of monomer including dental monomers and dental alloy-component metal elements using this test. Monomers including Bis-GMA contained in base resin of composite resin exhibited weak embryotoxicity, and the toxicity level varied among dental alloy-component metal elements...
August 2016: Japanese Dental Science Review
https://www.readbyqxmd.com/read/28396865/biomaterials-for-dental-applications
#19
EDITORIAL
Elif Bahar Tuna, Yoshiki Oshida, Bugra Ozen, Elizabeta Gjorgievska, Tamer Tuzuner
No abstract text is available yet for this article.
2017: BioMed Research International
https://www.readbyqxmd.com/read/28389072/the-characteristics-of-mineral-trioxide-aggregate-polycaprolactone-3-dimensional-scaffold-with-osteogenesis-properties-for-tissue-regeneration
#20
Yung-Cheng Chiu, Hsin-Yuan Fang, Tuan-Ti Hsu, Cheng-Yao Lin, Ming-You Shie
INTRODUCTION: The aim of this study was to investigate whether the mineral trioxide aggregate/polycaprolactone (MTA/PCL) hybrid 3-dimensional (3D) scaffold supplies a suitable microenvironment for the osteogenic differentiation of human dental pulp cells (hDPCs) and to further consider the effect of the MTA/PCL composite on the biological performance of hybrid scaffolds. METHODS: MTA was suspended in absolute alcohol and dropped slowly into PCL that was generated with the printable MTA-matrix...
April 4, 2017: Journal of Endodontics
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