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Dental Biomaterials

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https://www.readbyqxmd.com/read/28087075/cellular-transcriptional-response-to-zirconia-based-implant-materials
#1
Brigitte Altmann, Kerstin Rabel, Ralf J Kohal, Susanne Proksch, Pascal Tomakidi, Erik Adolfsson, Falk Bernsmann, Paola Palmero, Tobias Fürderer, Thorsten Steinberg
OBJECTIVE: To adequately address clinically important issues such as osseointegration and soft tissue integration, we screened for the direct biological cell response by culturing human osteoblasts and gingival fibroblasts on novel zirconia-based dental implant biomaterials and subjecting them to transcriptional analysis. METHODS: Biomaterials used for osteoblasts involved micro-roughened surfaces made of a new type of ceria-stabilized zirconia composite with two different topographies, zirconium dioxide, and yttria-stabilized zirconia (control)...
January 10, 2017: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/28081293/role-of-pyridoxal-5-phosphate-at-the-titanium-implant-interface-in-vivo-increased-hemophilicity-inactive-platelet-adhesion-and-osteointegration
#2
Jung Seung Lee, Kyuri Kim, Joseph P Park, Seung-Woo Cho, Haeshin Lee
Titanium is the most biocompatible inorganic biomaterial with a long history of use in orthopedic and dental implants. However, promoting rapid and effective bone formation and integration onto etched, rough TiO2 surfaces has been a challenging topic. Here, 21 commercially available molecules are examined that met the following criteria: (1) contain phosphonic acid for stable immobilization onto TiO2 surfaces and (2) have a molecular weight less than 500 Da for negligible coating thickness. Of these molecules, the surface immobilization of pyridoxal 5'-phosphate (PLP), an active form of vitamin B6 , dramatically increases the hemophilic property of the surface and accelerated osteointegration in vivo...
January 12, 2017: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/28070691/biological-characteristic-effects-of-human-dental-pulp-stem-cells-on-poly-%C3%AE%C2%B5-caprolactone-biphasic-calcium-phosphate-fabricated-scaffolds-using-modified-melt-stretching-and-multilayer-deposition
#3
Natkrita Wongsupa, Thongchai Nuntanaranont, Suttatip Kamolmattayakul, Nuttawut Thuaksuban
Craniofacial bone defects such as alveolar cleft affect the esthetics and functions that need bone reconstruction. The advanced techniques of biomaterials combined with stem cells have been a challenging role for maxillofacial surgeons and scientists. PCL-coated biphasic calcium phosphate (PCL-BCP) scaffolds were created with the modified melt stretching and multilayer deposition (mMSMD) technique and merged with human dental pulp stem cells (hDPSCs) to fulfill the component of tissue engineering for bone substitution...
February 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28067359/antibacterial-properties-of-nanostructured-cu-tio2-surfaces-for-dental-implants
#4
Jonathan Rosenbaum, Davy Louis Versace, Samir Abbad-Andallousi, Remi Pires, Christophe Azevedo, Pierre Cénédese, Pierre Dubot
The influence of copper derived TiO2 surfaces (nCu-nT-TiO2) on the death of nosocomial Staphylococcus aureus (Sa) and Escherichia coli (Ec), was investigated. TiO2 nanotube (nT-TiO2) arrays were fabricated by anodic oxidation of pure titanium sheets in fluorhydric solutions, leading to surface nanostructuration and creation of specific reactive sites. Copper nanocubes with a mean size of 20 nm have been synthesized and deposited on the nT-TiO2 surface by pulsed electrodeposition from a copper sulphate solution...
January 9, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28050314/biocompatibility-study-of-lithium-disilicate-and-zirconium-oxide-ceramics-for-esthetic-dental-abutments
#5
Céline Brunot-Gohin, Jean-Luc Duval, Sandra Verbeke, Kayla Belanger, Isabelle Pezron, Gérard Kugel, Dominique Laurent-Maquin, Sophie Gangloff, Christophe Egles
PURPOSE: The increasing demand for esthetically pleasing results has contributed to the use of ceramics for dental implant abutments. The aim of this study was to compare the biological response of epithelial tissue cultivated on lithium disilicate (LS2) and zirconium oxide (ZrO2) ceramics. Understanding the relevant physicochemical and mechanical properties of these ceramics will help identify the optimal material for facilitating gingival wound closure. METHODS: Both biomaterials were prepared with 2 different surface treatments: raw and polished...
December 2016: Journal of Periodontal & Implant Science
https://www.readbyqxmd.com/read/28000273/evolution-of-loading-protocols-in-implant-dentistry-for-partially-dentate-arches
#6
REVIEW
Dean Morton, Adrien Pollini
Better outcomes for patients receiving dental implants as part of oral rehabilitation remains a constant goal. Advances in implant design, clinical protocols and biomaterials provide opportunities to accelerate treatment, increasing efficiency, predictability and patient satisfaction. It is important to understand that these changes can result in negative outcomes and increased risk. This article reviews the existing published evidence relating to accelerated clinical protocols and patient outcomes. Subsequent to the review, clinical recommendations are offered...
February 2017: Periodontology 2000
https://www.readbyqxmd.com/read/27987682/porous-magnesium-based-scaffolds-for-tissue-engineering
#7
REVIEW
Mostafa Yazdimamaghani, Mehdi Razavi, Daryoosh Vashaee, Keyvan Moharamzadeh, Aldo R Boccaccini, Lobat Tayebi
Significant amount of research efforts have been dedicated to the development of scaffolds for tissue engineering. Although at present most of the studies are focused on non-load bearing scaffolds, many scaffolds have also been investigated for hard tissue repair. In particular, metallic scaffolds are being studied for hard tissue engineering due to their suitable mechanical properties. Several biocompatible metallic materials such as stainless steels, cobalt alloys, titanium alloys, tantalum, nitinol and magnesium alloys have been commonly employed as implants in orthopedic and dental treatments...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27987667/effect-of-preconditioning-cobalt-and-nickel-based-dental-alloys-with-bacillus-sp-extract-on-their-surface-physicochemical-properties-and-theoretical-prediction-of-candida-albicans-adhesion
#8
Mounyr Balouiri, Samira Bouhdid, Moulay Sadiki, Wessal Ouedrhiri, Hassan Barkai, Omar El Farricha, Saad Koraichi Ibnsouda, El Houssaine Harki
Biofilm formation on dental biomaterials is implicated in various oral health problems. Thus the challenge is to prevent the formation of this consortium of microorganisms using a safe approach such as antimicrobial and anti-adhesive natural products. Indeed, in the present study, the effects of an antifungal extract of Bacillus sp., isolated from plant rhizosphere, on the surface physicochemical properties of cobalt and nickel based dental alloys were studied using the contact angle measurements. Furthermore, in order to predict the adhesion of Candida albicans to the treated and untreated dental alloys, the total free energy of adhesion was calculated based on the extended Derjaguin-Landau-Verwey-Overbeek approach...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27978808/molecular-cellular-and-pharmaceutical-aspects-of-biomaterials-in-dentistry-and-oral-and-maxillofacial-surgery-an-internationalization-of-higher-education-and-research-perspective
#9
Lidia M Wisniewska, David M Dohan Ehrenfest, Pablo Galindo-Moreno, Jesús Domingo Segovia, Francesco Inchingolo, Hom-Lay Wang, Manuel Fernándes-Cruz
In dentistry and oral and maxillofacial surgery, the development of implantable biomaterials and the understanding of their molecular, cellular and pharmaceutical aspects are currently major fields of research and education, with a considerable impact on the daily clinical practice and the evolution of therapeutic strategies. In the era of globalized economy of knowledge and science, this scientific domain needs the development of global cooperation and a paradigm evolution in the organizational culture of the dental sciences and related dental industry...
December 13, 2016: Current Pharmaceutical Biotechnology
https://www.readbyqxmd.com/read/27941125/histatin-1-enhances-cell-adhesion-to-titanium-in-an-implant-integration-model
#10
I A van Dijk, A F Beker, W Jellema, K Nazmi, G Wu, D Wismeijer, P M Krawczyk, J G M Bolscher, E C I Veerman, J Stap
Cellular adhesion is essential for successful integration of dental implants. Rapid soft tissue integration is important to create a seal around the implant and prevent infections, which commonly cause implant failure and can result in bone loss. In addition, soft tissue management is important to obtain good dental aesthetics. We previously demonstrated that the salivary peptide histatin 1 (Hst1) causes a more than 2-fold increase in the ability of human adherent cells to attach and spread on a glass surface...
December 1, 2016: Journal of Dental Research
https://www.readbyqxmd.com/read/27909893/osteogain%C3%A2-loaded-onto-an-absorbable-collagen-sponge-induces-attachment-and-osteoblast-differentiation-of-st2-cells-in-vitro
#11
Richard J Miron, Masako Fujioka-Kobayashi, Yufeng Zhang, Anton Sculean, Benjamin Pippenger, Yoshinori Shirakata, Umadevi Kandalam, Maria Hernandez
OBJECTIVES: Dimensional changes of the alveolar bone following tooth extraction are a major challenge in daily dental practice. To limit bone loss, a variety of biomaterials including bone grafts, barrier membranes, and growth factors have been utilized either alone or in combination therapies to increase the speed and quality of new bone formation. The aim of the present in vitro study was to investigate the regenerative potential of Osteogain®, a new liquid carrier system of enamel matrix derivative (EMD) in combination with an absorbable collagen sponge (ACS) specifically designed for extraction socket healing...
December 1, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27872014/the-bone-implant-interface-of-dental-implants-in-humans-on-the-atomic-scale
#12
Gustav Sundell, Christer Dahlin, Martin Andersson, Mattias Thuvander
: Osseointegration of dental implants occurs on a hierarchy of length scales down to the atomic level. A deeper understanding of the complex processes that take place at the surface of an implant on the smallest scale is of interest for the development of improved biomaterials. To date, transmission electron microscopy (TEM) has been utilized for examination of the bone-implant interface, providing details on the nanometer level. In this study we show that TEM imaging can be complemented with atom probe tomography (APT) to reveal the chemical composition of a Ti-based dental implant in a human jaw on the atomic level of resolution...
November 19, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27818690/stem-cells-of-dental-origin-current-research-trends-and-key-milestones-towards-clinical-application
#13
REVIEW
Athina Bakopoulou, Imad About
Dental Mesenchymal Stem Cells (MSCs), including Dental Pulp Stem Cells (DPSCs), Stem Cells from Human Exfoliated Deciduous teeth (SHED), and Stem Cells From Apical Papilla (SCAP), have been extensively studied using highly sophisticated in vitro and in vivo systems, yielding substantially improved understanding of their intriguing biological properties. Their capacity to reconstitute various dental and nondental tissues and the inherent angiogenic, neurogenic, and immunomodulatory properties of their secretome have been a subject of meticulous and costly research by various groups over the past decade...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27806754/-issues-confronted-with-biomaterials-research-and-development-and-market-access-in-craniomaxillofacial-field
#14
M Hu
There are a variety of biomedical materials applied in craniomaxillofacial and dental clinical practice, plastic surgery, otorhinolaryngology and neurosurgery. With the increasing investment for the biomedical materials study, considerable progress has been obtained in biomaterials research. But overall, the field of biomaterials in China is still in a backward state. The development of advanced manufacturing technology has put forward new demands for the research of biological materials and has expanded the application, but at present, there are few biomaterials that meet the requirements...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27796686/biological-evaluation-of-ultrananocrystalline-and-nanocrystalline-diamond-coatings
#15
Shelby A Skoog, Girish Kumar, Jiwen Zheng, Anirudha V Sumant, Peter L Goering, Roger J Narayan
Nanostructured biomaterials have been investigated for achieving desirable tissue-material interactions in medical implants. Ultrananocrystalline diamond (UNCD) and nanocrystalline diamond (NCD) coatings are the two most studied classes of synthetic diamond coatings; these materials are grown using chemical vapor deposition and are classified based on their nanostructure, grain size, and sp(3) content. UNCD and NCD are mechanically robust, chemically inert, biocompatible, and wear resistant, making them ideal implant coatings...
December 2016: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/27789947/effects-of-nanoporous-anodic-titanium-oxide-on-human-adipose-derived-stem-cells
#16
Katarzyna Malec, Joanna Góralska, Magdalena Hubalewska-Mazgaj, Paulina Głowacz, Magdalena Jarosz, Pawel Brzewski, Grzegorz D Sulka, Marian Jaskuła, Iwona Wybrańska
The aim of current bone biomaterials research is to design implants that induce controlled, guided, successful, and rapid healing. Titanium implants are widely used in dental, orthopedic, and reconstructive surgery. A series of studies has indicated that cells can respond not only to the chemical properties of the biomaterial, but also, in particular, to the changes in surface topography. Nanoporous materials remain in focus of scientific queries due to their exclusive properties and broad applications. One such material is nanostructured titanium oxide with highly ordered, mutually perpendicular nanopores...
2016: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/27769674/saving-single-rooted-teeth-with-combined-endodontic-periodontal-lesions
#17
Alexandre Pico-Blanco, Pablo Castelo-Baz, Leticia Caneiro-Queija, Antonio Liñares-González, Pablo Martin-Lancharro, Juan Blanco-Carrión
INTRODUCTION: Teeth affected by combined endodontic-periodontal lesions are usually considered by all prognosis classifications as hopeless teeth. The development of new biomaterials combined with modern endodontic and periodontal regeneration techniques may improve dental prognosis and maintain the affected teeth. Moreover, 1 of the replacement options for those teeth, dental implants, has shown an increasing number of biological and technical complications. METHODS: Five patients were included in this case series study...
December 2016: Journal of Endodontics
https://www.readbyqxmd.com/read/27763970/evaluation-of-the-biocompatibility-of-new-fiber-reinforced-composite-materials-for-craniofacial-bone-reconstruction
#18
Mădălina-Anca Lazar, Horaţiu Rotaru, Ioana Bâldea, Adina B Boşca, Cristian P Berce, Cristina Prejmerean, Doina Prodan, Radu S Câmpian
This study aims to assess the biocompatibility of new advanced fiber-reinforced composites (FRC) to be used for custom-made cranial implants. Four new formulations of FRC were obtained using polymeric matrices (combinations of monomers bisphenol A glycidylmethacrylate [bis-GMA], urethane dimethacrylate [UDMA], triethylene glycol dimethacrylate [TEGDMA], hydroxyethyl methacrylate [HEMA]) and E-glass fibers (300 g/mp). Every FRC contains 65% E-glass and 35% polymeric matrix. Composition of polymeric matrices are: bis-GMA (21%), TEGDMA (14%) for FRC1; bis-GMA (21%), HEMA (14%) for FRC2; bis-GMA (3...
October 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27740641/tissue-integration-of-a-volume-stable-collagen-matrix-in-an-experimental-soft-tissue-augmentation-model
#19
Luca Ferrantino, Dieter Bosshardt, Myron Nevins, Giacomo Santoro, Massimo Simion, David Kim
Reducing the need for a connective tissue graft by using an efficacious biomaterial is an important task for dental professionals and patients. This experimental study aimed to test the soft tissue response to a volume-stable new collagen matrix. The device demonstrated good stability during six different time points ranging from 0 to 90 days of healing with no alteration of the wound-healing processes. The 90-day histologic specimen demonstrates eventual replacement of most of the matrix with new connective tissue fibers...
November 2016: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/27728810/exosomes-as-biomimetic-tools-for-stem-cell-differentiation-applications-in-dental-pulp-tissue-regeneration
#20
Chun-Chieh Huang, Raghuvaran Narayanan, Satish Alapati, Sriram Ravindran
Achieving and maintaining safe and reliable lineage specific differentiation of stem cells is important for clinical translation of tissue engineering strategies. In an effort to circumvent the multitude of problems arising from the usage of growth factors and growth factor delivery systems, we have explored the use of exosomes as biomimetic tools to induce stem cell differentiation. Working on the hypothesis that cell-type specific exosomes can trigger lineage-specific differentiation of stem cells, we have evaluated the potential of exosomes derived from dental pulp cells cultured on under growth and odontogenic differentiation conditions to induce odontogenic differentiation of naïve human dental pulp stem cells (DPSCs) and human bone marrow derived stromal cells (HMSCs) in vitro and in vivo...
December 2016: Biomaterials
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