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Multiple organ system failure

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https://www.readbyqxmd.com/read/29054504/proteomics-in-plasma-of-ovariectomized-rats-and-those-exposed-to-estradiol-valerate
#1
Hai Jiang, Wenpei Bai, Wenjuan Wang, Ke Wang, Jing Jia, Jing Zhang, He Diao, Lihua Qin
The menopausal period, an inevitable physiological process for women, is frequently associated with physiological and psychological dysfunction attributable to substantial fluctuation and gradual decrease in female hormones induced by ovarian failure, leading to corresponding symptoms and diseases that impact multiple systems in the body to varying degrees. As prior studies have focused primarily on menopausal syndrome-related pathophysiological changes and hormone replacement therapy effects, here we approached menopausal disease incidence risk and pathogenesis through systemic plasma proteomics analysis...
October 17, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29052064/determinants-of-variability-in-management-of-acute-calculous-cholecystitis
#2
Philippe Paci, Nancy E Mayo, Pepa A Kaneva, Julio F Fiore, Gerald M Fried, Liane S Feldman
BACKGROUND: While evidence supports early compared to delayed cholecystectomy as optimal management of acute calculous cholecystitis (ACC), significant variability in practice remains. The purpose of this study was to identify variables associated with early cholecystectomy, to target opportunities to improve adherence to best practices. METHODS: Adult patients admitted to surgical units with ACC at two hospitals in a university hospital network between June 2010 and January 2015 were reviewed...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29027919/shiga-toxins-induce-apoptosis-and-er-stress-in-human-retinal-pigment-epithelial-cells
#3
Jun-Young Park, Yu-Jin Jeong, Sung-Kyun Park, Sung-Jin Yoon, Song Choi, Dae Gwin Jeong, Su Wol Chung, Byung Joo Lee, Jeong Hun Kim, Vernon L Tesh, Moo-Seung Lee, Young-Jun Park
Shiga toxins (Stxs) produced by Shiga toxin-producing bacteria Shigella dysenteriae serotype 1 and select serotypes of Escherichia coli are the most potent known virulence factors in the pathogenesis of hemorrhagic colitis progressing to potentially fatal systemic complications such as acute renal failure, blindness and neurological abnormalities. Although numerous studies have defined apoptotic responses to Shiga toxin type 1 (Stx1) or Shiga toxin type 2 (Stx2) in a variety of cell types, the potential significance of Stx-induced apoptosis of photoreceptor and pigmented cells of the eye following intoxication is unknown...
October 13, 2017: Toxins
https://www.readbyqxmd.com/read/29023881/review-article-the-role-of-the-microcirculation-in-liver-cirrhosis
#4
REVIEW
T Davies, S Wythe, J O'Beirne, D Martin, E Gilbert-Kawai
BACKGROUND: Intrahepatic microvascular derangements and microcirculatory dysfunction are key in the development of liver cirrhosis and its associated complications. While much has been documented relating to cirrhosis and the dysfunction of the microcirculation in the liver parenchyma, far less is known about the state of the extrahepatic microcirculation and the role this may have in the pathogenesis of multiple organ failure in end stage liver cirrhosis. AIM: To provide an update on the role of the microcirculation in the pathophysiology of cirrhosis and its associated complications and briefly discuss some of the imaging techniques which may be used to directly investigate the microcirculation...
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29022266/cardiac-aging-benefits-of-exercise-nrf2-activation-and-antioxidant-signaling
#5
Madhusudhanan Narasimhan, Namakkal-Soorappan Rajasekaran
Cardiovascular dysfunction and heart failure associated with aging not only impairs the cardiac function but also the quality of life eventually decreasing the life expectancy of the elderly. Notably, cardiac tissue can prematurely age under certain conditions such as genetic mutation, persistent redox stress and overload, aberrant molecular signaling, DNA damage, telomere attrition, and other pathological insults. While cardiovascular-related morbidity and mortality is on the rise and remains a global health threat, there has been only little to moderate improvements in its medical management...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29018518/cardiac-effects-of-lightning-strikes
#6
Theodoros Christophides, Sarosh Khan, Mahmood Ahmad, Hossam Fayed, Richard Bogle
Lightning strikes are a common and leading cause of morbidity and mortality. Multiple organ systems can be involved, though the effects of the electrical current on the cardiovascular system are one of the main modes leading to cardiorespiratory arrest in these patients. Cardiac effects of lightning strikes can be transient or persistent, and include benign or life-threatening arrhythmias, inappropriate therapies from cardiac implantable electronic devices, cardiac ischaemia, myocardial contusion, pericardial disease, aortic injury, as well as cardiomyopathy with associated ventricular failure...
August 2017: Arrhythmia & Electrophysiology Review
https://www.readbyqxmd.com/read/28988067/the-effect-of-resuscitation-strategy-on-the-longitudinal-immuno-inflammatory-response-to-blunt-trauma
#7
Alexander Bonde, Ask Tybjærg Nordestgaard, Rasmus Kirial, Peter Svenningsen, Martin Sillesen
INTRODUCTION: Resuscitation strategies following blunt trauma have been linked to immuno-inflammatory complications leading to systemic inflammatory syndrome (SIRS), sepsis and multiple organ failure (MOF). The effect of resuscitation strategy on longitudinal inflammation marker trajectories is, however, unknown. We hypothesized that the effect of resuscitation strategy extends beyond the trauma-related coagulopathy, perhaps affecting the longitudinal immuno-inflammatory response to injury...
September 28, 2017: Injury
https://www.readbyqxmd.com/read/28983256/targeting-microrna-function-in-acute-pancreatitis
#8
REVIEW
Hong Xiang, Xufeng Tao, Shilin Xia, Jialin Qu, Huiyi Song, Jianjun Liu, Dong Shang
Acute pancreatitis (AP) is a common gastrointestinal disorder that featured by acute inflammatory responses leading to systemic inflammatory response syndrome (SIRS) or multiple organ failure. A worldwide increase in annual incidence has been observed during the past decade with high acute hospitalization and mortality. Lack of any specific treatment for AP, even to this day, is a reminder that there is much to be learned about the exact pathogenesis of AP. Fortunately, the discovery of microRNA (miRNA) has started an entirely new thought process regarding the molecular mechanism associated with the disease processes...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28977260/prevalence-of-multiple-organ-dysfunction-in-the-pediatric-intensive-care-unit-pediatric-risk-of-mortality-iii-versus-pediatric-logistic-organ-dysfunction-scores-for-mortality-prediction
#9
Azza Abd Elkader El Hamshary, Seham Awad El Sherbini, HebatAllah Fadel Elgebaly, Samah Abdelkrim Amin
OBJECTIVES: To assess the frequency of primary multiple organ failure and the role of sepsis as a causative agent in critically ill pediatric patients; and calculate and evaluate the accuracy of the Pediatric Risk of Mortality III (PRISM III) and Pediatric Logistic Organ Dysfunction (PELOD) scores to predict the outcomes of critically ill children. METHODS: Retrospective study, which evaluated data from patients admitted from January to December 2011 in the pediatric intensive care unit of the Children's Hospital of the University of Cairo...
April 2017: Revista Brasileira de Terapia Intensiva
https://www.readbyqxmd.com/read/28977204/tadalafil-protective-action-against-the-development-of-multiple-organ-failure-syndrome
#10
Granville G de Oliveira, Samer A H de Oliveira, Paulo Henrique H Botelho, Marcos Aurelio Barboza de Oliveira, Ka Bian, Ferid Murad
INTRODUCTION: Multiple organ failure syndrome (MOFS) is a pathology associated to unspecified and severe trauma, characterized by elevated morbidity and mortality. The complex inflammatory MOFS-related reactions generate important ischemia-reperfusion responses in the induction of this syndrome. Nitric oxide elevation, through the activation of cyclic guanosine monophosphate (cGMP), has the potential of counteracting the typical systemic vasoconstriction, and platelet-induced hypercoagulation...
July 2017: Brazilian Journal of Cardiovascular Surgery
https://www.readbyqxmd.com/read/28975653/analysis-of-skeletal-muscle-microcirculation-in-a-porcine-polytrauma-model-with-haemorrhagic-shock
#11
Zhi Qiao, Klemens Horst, Michel Teuben, Johannes Greven, Luxu Yin, Yannik Kalbas, René H Tolba, Hans-Christoph Pape, Frank Hildebrand, Roman Pfeifer
Polytraumatised patients with haemorrhagic shock are prone to develop systemic complications, such as SIRS (systemic inflammatory response syndrome), ARDS (acute respiratory distress syndrome) and MOF (multiple organ failure). The pathomechanism of severe complications following trauma is multifactorial, and it is believed that microcirculatory dysfunction plays an important role. The aim of this study was to determine the changes in the microcirculation in musculature over time during shock and subsequent resuscitation in a porcine model of haemorrhagic shock and polytrauma...
October 3, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28974669/non-exertional-heatstroke-a-case-report-and-review-of-the-literature
#12
Chiara Mozzini, Giovanni Xotta, Ulisse Garbin, Anna Maria Fratta Pasini, Luciano Cominacini
BACKGROUND Heatstroke (HS) is a life-threatening condition characterized by an elevation of the core body temperature above 40°C, central nervous system dysfunction, and possible multi-organ failure. HS can trigger systemic inflammation, disseminated intravascular coagulation (DIC), rhabdomyolysis, cerebral edema and seizures, pulmonary edema, heart dysfunctions, and renal and hepatic failure. CASE REPORT We report the case of a 41-year-old Romanian woman with a history of alcoholism who developed HS after arriving by bus in Verona, Italy in June 2016...
October 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28974562/autophagy-and-mitochondrial-biogenesis-impairment-contributes-to-age-dependent-liver-injury-in-experimental-sepsis-dysregulation-of-amp-activated-protein-kinase-pathway
#13
Yu Inata, Satoshi Kikuchi, Ravi S Samraj, Paul W Hake, Michael O'Connor, John R Ledford, James O'Connor, Patrick Lahni, Vivian Wolfe, Giovanna Piraino, Basilia Zingarelli
Age is an independent risk factor of multiple organ failure in patients with sepsis. However, the age-related mechanisms of injury are not known. AMPK is a crucial regulator of energy homeostasis, which controls mitochondrial biogenesis by activation of peroxisome proliferator-activated receptor-γ coactivator-α (PGC-1α) and disposal of defective organelles by autophagy. We investigated whether AMPK dysregulation might contribute to age-dependent liver injury in young (2-3 mo) and mature male mice (11-13 mo) subjected to sepsis...
October 3, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28971835/the-pump-the-exchanger-and-the-holy-spirit-origins-of-the-endogenous-ouabain-hypertension-hypothesis-and-its-40-year-evolution
#14
Mordecai P Blaustein
Two prescient 1953 publications set the stage for elucidating a novel endocrine system: Schatzmann's report that cardiotonic steroids (CTSs) are all Na(+) pump inhibitors, and Szent-Gyorgi's suggestion that there is an endogenous "missing screw" in heart failure that CTSs like digoxin may replace. In 1977 I postulated that an endogenous Na(+) pump inhibitor acts as a natriuretic hormone and simultaneously elevates blood pressure (BP) in salt-dependent hypertension. This hypothesis was based on the idea that excess renal salt retention promoted the secretion of a CTS-like hormone that inhibits renal Na(+) pumps and salt reabsorption...
September 27, 2017: American Journal of Physiology. Cell Physiology
https://www.readbyqxmd.com/read/28968277/vasculotide-an-angiopoietin-1-mimetic-restores-microcirculatory-perfusion-and-microvascular-leakage-and-decreases-fluid-resuscitation-requirements-in-hemorrhagic-shock
#15
Michelle Trieu, Matijs van Meurs, Anoek L I van Leeuwen, Paul Van Slyke, Van Hoang, Leo M G Geeraedts, Christa Boer, Charissa E van den Brom
BACKGROUND: Microcirculatory dysfunction is associated with multiple organ failure and unfavorable patient outcome. We investigated whether therapeutically targeting the endothelial angiopoietin/Tie2 system preserves microvascular integrity during hemorrhagic shock. METHODS: Rats were treated with the angiopoietin-1 mimetic Vasculotide and subjected to hemorrhagic shock and fluid resuscitation. Microcirculatory perfusion and leakage were assessed with intravital microscopy (n = 7 per group) and Evans blue dye extravasation (n = 8 per group), respectively...
September 29, 2017: Anesthesiology
https://www.readbyqxmd.com/read/28968251/hypothermia-does-not-influence-liver-damage-and-function-in-a-porcine-polytrauma-model
#16
D Eschbach, K Horst, M Sassen, J Andruszkow, J Mohr, F Debus, N Vogt, T Steinfeldt, F Hildebrand, K Schöller, E Uhl, H Wulf, S Ruchholtz, H Pape, M Frink
BACKGROUND: Previous studies revealed evidence that induced hypothermia attenuates ischemic organ injuries after severe trauma. In the present study, the effect of hypothermia on liver damage was investigated in a porcine long term model of multi-system injury, consisting of blunt chest trauma, penetrating abdominal trauma, musculoskeletal injury, and hemorrhagic shockMETHODS: In 30 pigs, a standardized polytrauma including blunt chest trauma, penetrating abdominal trauma, musculoskeletal injury, and hemorrhagic shock of 45% of total blood volume was induced...
September 15, 2017: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/28967709/liver-fibrosis-score-predicts-mortality-in-heart-failure-patients-with-preserved-ejection-fraction
#17
Akiomi Yoshihisa, Yu Sato, Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Shu-Ichi Saitoh, Yasuchika Takeishi
AIMS: Heart failure with preserved ejection fraction (HFpEF) has several pathophysiological aspects, including stiffness and/or congestion of multiple organs. Poor prognosis is expected in heart failure patients with liver stiffness, which has recently been assessed by non-alcoholic fatty liver disease fibrosis score (NFS; based on aspartate aminotransferase to alanine aminotransferase ratio, platelet counts, and albumin). We aimed to investigate the impact of NFS on prognosis of HFpEF patients, with consideration for the peripheral collagen markers such as procollagen type III peptide (PIIIP), type IV collagen 7S, and hyaluronic acid...
October 2, 2017: ESC Heart Failure
https://www.readbyqxmd.com/read/28965489/barriers-and-facilitators-of-the-hiv-care-continuum-in-southern-new-england-for-people-with-drug-or-alcohol-use-and-living-with-hiv-aids-perspectives-of-hiv-surveillance-experts-and-service-providers
#18
Lauretta E Grau, Abbie Griffiths-Kundishora, Robert Heimer, Marguerite Hutcheson, Amy Nunn, Caitlin Towey, Thomas J Stopka
BACKGROUND: Contemporary studies about HIV care continuum (HCC) outcomes within substance using populations primarily focus on individual risk factors rather than provider- or systems-level influences. Over 25% of people living with HIV (PLWH) have substance use disorders that can alter their path through the HCC. As part of a study of HCC outcomes in nine small cities in Southern New England (population 100,000-200,000 and relatively high HIV prevalence particularly among substance users), this qualitative analysis sought to understand public health staff and HIV service providers' perspectives on how substance use may influence HCC outcomes...
October 2, 2017: Addiction Science & Clinical Practice
https://www.readbyqxmd.com/read/28953013/cutaneous-light-chain-deposition-disease-a-report-of-2-cases-and-review-of-the-literature
#19
Carlo Hendricks, Maite T Fernández Figueras, Julia Liersch, Maria-Teresa Martin-Urdà, Dolores López, Christoph Brochhausen, Christoph Röcken, Jörg Schaller
Light chain deposition disease (LCDD) is a rare systemic disorder with deposition of mostly monoclonal amorphous nonamyloid light chains in multiple organs. Renal involvement with rapidly progressing renal failure presents the dominant manifestation of LCDD. Approximately 20%-30% of patients show symptomatic cardiac or liver involvement. Cutaneous manifestations are extremely rare with only a few published cases. We report 2 additional cases of cutaneous LCDD without detectable systemic disease.
September 20, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28952056/pathophysiology-of-acute-heart-failure-syndrome-a-knowledge-gap
#20
REVIEW
Hani N Sabbah
Although much remains unknown regarding the pathophysiology of acute heart failure (AHF), precipitating events are thought to involve a complex set of interactions between the heart, kidneys, and peripheral vasculature. In addition to these interactions, which are considered the primary abnormalities in patients with AHF, several other organ systems may also be affected and contribute to disease progression. Currently available scientific literature suggests that the natural history and pathophysiology of AHF consists of two phases: (1) an "initiation phase" involving a series of triggering events, and (2) an "amplification phase," in which multiple mechanisms contribute to worsening HF and exacerbate end-organ damage...
September 26, 2017: Heart Failure Reviews
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