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https://www.readbyqxmd.com/read/28723581/the-structure-and-function-of-cell-membranes-studied-by-atomic-force-microscopy
#1
REVIEW
Yan Shi, Mingjun Cai, Lulu Zhou, Hongda Wang
The cell membrane, involved in almost all communications of cells and surrounding matrix, is one of the most complicated components of cells. Lack of suitable methods for the detection of cell membranes in vivo has sparked debates on the biochemical composition and structure of cell membranes over half a century. The development of single molecule techniques, such as AFM, SMFS, and TREC, provides a versatile platform for imaging and manipulating cell membranes in biological relevant environments. Here, we discuss the latest developments in AFM and the progress made in cell membrane research...
July 16, 2017: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/28721754/a-model-of-adaptation-for-families-of-elderly-patients-with-dementia-focusing-on-family-resilience
#2
Geun Myun Kim, Ji Young Lim, Eun Joo Kim, Sang Suk Kim
OBJECTIVES: We constructed a model explaining families' positive adaptation in chronic crisis situations such as the problematic behavior of elderly patients with dementia and attendant caregiving stress, based on the family resilience model. Our aim was to devise an adaptation model for families of elderly patients with dementia. METHOD: A survey of problematic behavior in elderly patients with dementia, family stress, family resilience, and family adaptation was conducted with 292 consenting individuals...
July 19, 2017: Aging & Mental Health
https://www.readbyqxmd.com/read/28719247/telehealth-in-schools-using-a-systematic-educational-model-based-on-fiction-screenplays-interactive-documentaries-and-three-dimensional-computer-graphics
#3
Diogo Julien Miranda, Chao Lung Wen
BACKGROUND: Preliminary studies suggest the need of a global vision in academic reform, leading to education re-invention. This would include problem-based education using transversal topics, developing of thinking skills, social interaction, and information-processing skills. We aimed to develop a new educational model in health with modular components to be broadcast and applied as a tele-education course. MATERIALS AND METHODS: We developed a systematic model based on a "Skills and Goals Matrix" to adapt scientific contents on fictional screenplays, three-dimensional (3D) computer graphics of the human body, and interactive documentaries...
July 18, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
https://www.readbyqxmd.com/read/28718963/peer-support-for-families-of-children-with-complex-needs-development-and-dissemination-of-a-best-practice-toolkit
#4
J Schippke, C Provvidenza, S Kingsnorth
BACKGROUND: Benefits of peer support interventions for families of children with disabilities and complex medical needs have been described in the literature. An opportunity to create an evidence-informed resource to synthesize best practices in peer support for program providers was identified. The objective of this paper is to describe the key activities used to develop and disseminate the Peer Support Best Practice Toolkit. METHODS: This project was led by a team of knowledge translation experts at a large pediatric rehabilitation hospital using a knowledge exchange framework...
July 18, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28716793/the-realities-of-partnership-in-person-centred-care-a-qualitative-interview-study-with-patients-and-professionals
#5
Axel Wolf, Lucy Moore, Doris Lydahl, Öncel Naldemirci, Mark Elam, Nicky Britten
OBJECTIVE: Although conceptual definitions of person-centred care (PCC) vary, most models value the involvement of patients through patient-professional partnerships. While this may increase patients' sense of responsibility and control, research is needed to further understand how this partnership is created and perceived. This study aims to explore the realities of partnership as perceived by patients and health professionals in everyday PCC practice. DESIGN: Qualitative study employing a thematic analysis of semistructured interviews with professionals and patients...
July 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28716434/training-midwives-to-perform-basic-obstetric-point-of-care-ultrasound-in-rural-areas-using-a-tablet-platform-and-mobile-phone-transmission-technology-a-wfumb-coe-project
#6
Sudhir Vinayak, Joyce Sande, Harvey Nisenbaum, Christian Pállson Nolsøe
Point-of-care ultrasound (POCUS) has become a topical subject and can be applied in a variety of ways with differing outcomes. The cost of all diagnostic procedures including obstetric ultrasound examinations is a major factor in the developing world and POCUS is only useful if it can be equated to good outcomes at a lower cost than a routine obstetric examination. The aim of this study was to assess a number of processes including accuracy of images and reports generated by midwives, performance of a tablet-sized ultrasound scanner, training of midwives to complete ultrasounds, teleradiology solution transmissions of images via internet, review of images by a radiologist, communication between midwife and radiologist, use of this technique to identify high-risk patients and improvement of the education and teleradiology model components...
July 14, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28715477/the-rhlr-quorum-sensing-receptor-controls-pseudomonas-aeruginosa-pathogenesis-and-biofilm-development-independently-of-its-canonical-homoserine-lactone-autoinducer
#7
Sampriti Mukherjee, Dina Moustafa, Chari D Smith, Joanna B Goldberg, Bonnie L Bassler
Quorum sensing (QS) is a bacterial cell-to-cell communication process that relies on the production, release, and response to extracellular signaling molecules called autoinducers. QS controls virulence and biofilm formation in the human pathogen Pseudomonas aeruginosa. P. aeruginosa possesses two canonical LuxI/R-type QS systems, LasI/R and RhlI/R, which produce and detect 3OC12-homoserine lactone and C4-homoserine lactone, respectively. Here, we use biofilm analyses, reporter assays, RNA-seq studies, and animal infection assays to show that RhlR directs both RhlI-dependent and RhlI-independent regulons...
July 17, 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28709194/effects-of-communication-burstiness-on-consensus-formation-and-tipping-points-in-social-dynamics
#8
C Doyle, B K Szymanski, G Korniss
Current models for opinion dynamics typically utilize a Poisson process for speaker selection, making the waiting time between events exponentially distributed. Human interaction tends to be bursty though, having higher probabilities of either extremely short waiting times or long periods of silence. To quantify the burstiness effects on the dynamics of social models, we place in competition two groups exhibiting different speakers' waiting-time distributions. These competitions are implemented in the binary naming game and show that the relevant aspect of the waiting-time distribution is the density of the head rather than that of the tail...
June 2017: Physical Review. E
https://www.readbyqxmd.com/read/28708093/real-time-communication-support-for-underwater-acoustic-sensor-networks-%C3%A2
#9
Rodrigo Santos, Javier Orozco, Matias Micheletto, Sergio F Ochoa, Roc Meseguer, Pere Millan, And Carlos Molina
Underwater sensor networks represent an important and promising field of research due to the large diversity of underwater ubiquitous applications that can be supported by these networks, e.g., systems that deliver tsunami and oil spill warnings, or monitor submarine ecosystems. Most of these monitoring and warning systems require real-time communication in wide area networks that have a low density of nodes. The underwater communication medium involved in these networks is very harsh and imposes strong restrictions to the communication process...
July 14, 2017: Sensors
https://www.readbyqxmd.com/read/28704594/critical-diagnoses-in-cytopathology-experience-at-a-large-medical-center
#10
Juan Xing, Lindsey Seigh, Sara E Monaco, N Paul Ohori, Samuel A Yousem, Rajnikant Amin, Liron Pantanowitz
BACKGROUND: Critical values have been well established and accepted in laboratory medicine, but to the authors' knowledge are less well accepted in anatomic pathology. Herein, the authors used a reporting process whereby reports with critical diagnoses were coded to ensure that the patient's clinical team was promptly notified electronically of this finding. The aim of the current study was to determine whether this coding mechanism was used appropriately for critical cytopathology diagnoses in the study health care system...
July 13, 2017: Cancer
https://www.readbyqxmd.com/read/28704128/commune-health-workers-methadone-maintenance-treatment-mmt-knowledge-and-perceived-difficulties-providing-decentralized-mmt-services-in-vietnam
#11
Chunqing Lin, Nguyen Anh Tuan, Li Li
BACKGROUND: With the initial establishment of countrywide methadone maintenance therapy (MMT) system, Vietnam is in the process of expanding and decentralizing the MMT program to community-based healthcare settings. OBJECTIVE: The study aimed to measure the MMT-related knowledge and perceived difficulties in treating patient who use drugs (PWUD) among community-based healthcare providers, e.g., commune health workers (CHW), and examine its correlated factors. METHODS: A total of 300 CHW from 60 communes in two provinces of Vietnam completed a survey using Audio Computer-Assisted Self-Interview (ACASI) method...
July 13, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28701946/the-nest-dry-run-mode-efficient-dynamic-analysis-of-neuronal-network-simulation-code
#12
Susanne Kunkel, Wolfram Schenck
NEST is a simulator for spiking neuronal networks that commits to a general purpose approach: It allows for high flexibility in the design of network models, and its applications range from small-scale simulations on laptops to brain-scale simulations on supercomputers. Hence, developers need to test their code for various use cases and ensure that changes to code do not impair scalability. However, running a full set of benchmarks on a supercomputer takes up precious compute-time resources and can entail long queuing times...
2017: Frontiers in Neuroinformatics
https://www.readbyqxmd.com/read/28700688/four-simple-rules-that-are-sufficient-to-generate-the-mammalian-blastocyst
#13
Silas Boye Nissen, Marta Perera, Javier Martin Gonzalez, Sophie M Morgani, Mogens H Jensen, Kim Sneppen, Joshua M Brickman, Ala Trusina
Early mammalian development is both highly regulative and self-organizing. It involves the interplay of cell position, predetermined gene regulatory networks, and environmental interactions to generate the physical arrangement of the blastocyst with precise timing. However, this process occurs in the absence of maternal information and in the presence of transcriptional stochasticity. How does the preimplantation embryo ensure robust, reproducible development in this context? It utilizes a versatile toolbox that includes complex intracellular networks coupled to cell-cell communication, segregation by differential adhesion, and apoptosis...
July 2017: PLoS Biology
https://www.readbyqxmd.com/read/28699891/lunatic-fringe-mediated-notch-signaling-regulates-adult-hippocampal-neural-stem-cell-maintenance
#14
Fatih Semerci, William Tin-Shing Choi, Aleksandar Bajic, Aarohi Thakkar, Juan Manuel Encinas, Frederic Depreux, Neil Segil, Andrew K Groves, Mirjana Maletic-Savatic
Hippocampal neural stem cells (NSCs) integrate inputs from multiple sources to balance quiescence and activation. Notch signaling plays a key role during this process. Here, we report that Lunatic fringe (Lfng), a key modifier of the Notch receptor, is selectively expressed in NSCs, and that Lfng in NSCs along with Notch ligands Delta1 and Jagged1 expressed by their progeny influence NSC recruitment, cell cycle duration and terminal fate. We propose a new model in which Lfng-mediated Notch signaling enables direct communication between a NSC and its descendants, so that progeny can send feedback signals to the "mother" cell to modify its cell cycle status...
July 12, 2017: ELife
https://www.readbyqxmd.com/read/28698129/an-efficient-agro-industrial-complex-in-almer%C3%A3-a-spain-towards-an-integrated-and-sustainable-bioeconomy-model
#15
REVIEW
Francisco J Egea, Roberto G Torrente, Alfredo Aguilar
In the last ten years, bioeconomy strategies and policy-related bioeconomy initiatives have been developed all over the world. Some of them are currently in the process of translation into specific actions. In most cases, the approaches followed have been top-down policy-related initiatives, triggered by the public sector originating a dynamic which can bring together different bioeconomy stakeholders i.e. industry, academia, financial operators and farmers. This article describes a bottom-up situation with unique bioeconomy-related features that deserve specific attention...
July 8, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28697729/the-relevance-of-different-trust-models-for-representation-in-patient-organizations-conceptual-considerations
#16
Helene Gerhards, Karin Jongsma, Silke Schicktanz
BACKGROUND: Trust within organizations is important for ensuring members' acceptance of the organization's activities and to expand their scope of action. Remarkably, Patient Organizations (POs) that often both function as a forum for self-help and represent patients on the health-political level, have been understudied in this respect. This paper analyzes the relation between trust and representation in POs. We distinguish between two models of representation originating from political theory: the trustee and delegate model and between two types of trust: horizontal and vertical trust...
July 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28693897/connexins-important-players-in-the-dissemination-of-prostate-cancer-cells
#17
REVIEW
Jonathan Boucher, Arnaud Monvoisin, Justine Vix, Marc Mesnil, Dominique Thuringer, Françoise Debiais, Laurent Cronier
Over the past 50 years, increasing experimental evidences have established that connexins (Cxs) and gap junctional intercellular communication (GJIC) ensure an important role in both the onset and development of cancerous processes. In the present review, we focus on the impact of Cxs and GJIC during the development of prostate cancer (PCa), from the primary growth mainly localized in acinar glands and ducts to the distant metastasis mainly concentrated in bone. As observed in several other types of solid tumours, Cxs and especially Cx43 exhibit an ambivalent role with a tumour suppressor effect in the early stages and, conversely, a rather pro-tumoral profile for most of invasion and dissemination steps to secondary sites...
July 7, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28691771/a-better-model-of-care-after-surgery-for-early-endometrial-cancer-comprehensive-needs-assessment-and-clinical-handover-to-a-woman-s-general-practitioner
#18
REVIEW
Ines M Rio, Orla McNally
BACKGROUND: Endometrial cancer is the most common invasive gynaecological cancer in Australia. Despite the fact that review after treatment of early endometrial cancer has not been shown to detect recurrent disease, practice at several hospitals brings women back for specialist hospital review for 5 years after definitive cancer surgery. AIM: Implement an improved model of follow-up care following hospital treatment for early endometrial cancer. EVALUATION METHODS: Quantitative and qualitative...
July 10, 2017: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/28691387/cascades-in-compartments-en-route-to-machine-assisted-biotechnology
#19
Kersten S Rabe, Joachim Müller, Marc Skoupi, Christof M Niemeyer
Biological compartmentalization is a fundamental principle of life that allows cells to metabolize, propagate or communicate with their environment. Much research is devoted to the understanding of this basic principle and to harness biomimetic compartments and catalytic cascades as tools for technological processes. We summarize the current state-of-the-art of these developments with a special emphasis on length scales, mass transport phenomena and molecular scaffolding approaches, ranging from small crosslinkers over proteins and nucleic acids to colloids and patterned surfaces...
July 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/28689393/inter-and-intra-observer-variability-of-the-volume-of-cervical-ossification-of-the-posterior-longitudinal-ligament-using-medical-image-processing-software
#20
Dong Ah Shin, Gyu Yeul Ji, Chang Hyun Oh, Keung Nyun Kim, Do Heum Yoon, Hyunchul Shin
OBJECTIVE: Computed tomography (CT)-based method of three dimensional (3D) analysis (MIMICS(®), Materialise, Leuven, Belgium) is reported as very useful software for evaluation of OPLL, but its reliability and reproducibility are obscure. This study was conducted to evaluate the accuracy of MIMICS(®) system, and inter- and intra-observer reliability in the measurement of OPLL. METHODS: Three neurosurgeons independently analyzed the randomly selected 10 OPLL cases with medical image processing software (MIMICS(®)) which create 3D model with Digital Imaging and Communication in Medicine (DICOM) data from CT images after brief explanation was given to examiners before the image construction steps...
July 2017: Journal of Korean Neurosurgical Society
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