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https://www.readbyqxmd.com/read/29783145/electrochemical-biosensor-system-using-a-cmos-microelectrode-array-provides-high-spatially-and-temporally-resolved-images
#1
William Tedjo, Jasmine E Nejad, Rachel Feeny, Lang Yang, Charles S Henry, Stuart Tobet, Tom Chen
The ability to view biological events in real time has contributed significantly to research in the life sciences. While video capture of real time changes in anatomical relationships is important, it is equally important to visualize real time changes in the chemical communications that drive cell behaviors. This paper describes an electrochemical imaging system capable of capturing changes in chemical gradients in live tissue slices. The system consists of a CMOS microchip with 8192 configurable Pt surface electrodes, on-chip potentiostat, on-chip control logic, and a microfluidic device designed to interface with the CMOS chip to support ex vivo tissue experimentation...
April 10, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29781980/disclosure-coaching-an-ask-tell-ask-model-to-support-clinicians-in-disclosure-conversations
#2
Jo Shapiro, Lynne Robins, Pamela Galowitz, Thomas H Gallagher, Sigall Bell
Error disclosure is a high-stakes, emotionally charged interaction for patients and families as well as clinicians. A failed disclosure can result in emotional distress, reduced patient and family trust, litigation, and lost opportunities to learn from and prevent subsequent errors. However, many clinicians have little expertise in handling these challenging interactions and can inadvertently make a bad situation worse. Even those clinicians who have had formal disclosure training may have trouble remembering what they were taught when faced with the need to actually discuss an error with patients...
May 16, 2018: Journal of Patient Safety
https://www.readbyqxmd.com/read/29781173/discourse-and-cognition-in-speakers-with-acquired-brain-injury-abi-a-systematic-review
#3
REVIEW
Elizabeth Hill, Mary Claessen, Anne Whitworth, Mark Boyes, Roslyn Ward
BACKGROUND: Cognitive impairment, particularly of executive functioning, has been implicated in deficits in spoken discourse production following acquired brain injury (ABI). However, due to variation in the methodologies and heterogeneity of findings across studies, the nature and extent of this association is not well understood. AIMS: This review aims to synthesize the literature investigating associations between cognitive deficits and discourse impairment after ABI...
May 20, 2018: International Journal of Language & Communication Disorders
https://www.readbyqxmd.com/read/29777324/a-dependable-massive-storage-service-for-medical-imaging
#4
Marco Antonio Núñez-Gaona, Ricardo Marcelín-Jiménez, Josefina Gutiérrez-Martínez, Heriberto Aguirre-Meneses, José Luis Gonzalez-Compean
We present the construction of Babel, a distributed storage system that meets stringent requirements on dependability, availability, and scalability. Together with Babel, we developed an application that uses our system to store medical images. Accordingly, we show the feasibility of our proposal to provide an alternative solution for massive scientific storage and describe the software architecture style that manages the DICOM images life cycle, utilizing Babel like a virtual local storage component for a picture archiving and communication system (PACS-Babel Interface)...
May 18, 2018: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/29777138/shining-light-on-molecular-mechanism-for-odor-selectivity-of-cnt-immobilized-olfactory-receptor
#5
Liyun Zhang, Yuan Yuan, Tian Ren, Yanzhi Guo, Chuan Li, Xuemei Pu
Olfactory receptor (OR)-based bioelectronic nose is a new type of bio-affinity sensor applied for detecting numerous odorant molecules. In order to elucidate the effect of the adsorption of nanomaterial carriers on the receptor structure and its selectivity to odors, we used a systematic computation-scheme to study two OR models immobilized onto carbon nanotube. Our result indicates that there is a multistep OR-adsorption process driven by hydrophobic interaction. Many allosteric communication pathways exist between the absorbed residues and the pocket ones, leading to a significant shrinkage of the pocket...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29773979/efficient-coding-and-energy-efficiency-are-promoted-by-balanced-excitatory-and-inhibitory-synaptic-currents-in-neuronal-network
#6
Lianchun Yu, Zhou Shen, Chen Wang, Yuguo Yu
Selective pressure may drive neural systems to process as much information as possible with the lowest energy cost. Recent experiment evidence revealed that the ratio between synaptic excitation and inhibition (E/I) in local cortex is generally maintained at a certain value which may influence the efficiency of energy consumption and information transmission of neural networks. To understand this issue deeply, we constructed a typical recurrent Hodgkin-Huxley network model and studied the general principles that governs the relationship among the E/I synaptic current ratio, the energy cost and total amount of information transmission...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29773700/implications-of-involving-pharmacy-technicians-in-obtaining-a-best-possible-medication-history-from-the-perspectives-of-pharmaceutical-medical-and-nursing-staff-a-qualitative-study
#7
Andrea Niederhauser, Chantal Zimmermann, Liat Fishman, David L B Schwappach
OBJECTIVES: In recent years, the involvement of pharmacy technicians in medication reconciliation has increasingly been investigated. The aim of this study was to assess the implications on professional roles and collaboration when a best possible medication history (BPMH) at admission is obtained by pharmacy technicians. DESIGN: Qualitative study with semistructured interviews. Data were analysed using a qualitative content analysis approach. SETTING: Internal medicine units in two mid-sized Swiss hospitals...
May 17, 2018: BMJ Open
https://www.readbyqxmd.com/read/29771550/daily-communication-conflict-resolution-and-marital-quality-in-chinese-marriage-a-three-wave-cross-lagged-analysis
#8
Xiaomin Li, Hongjian Cao, Nan Zhou, Xiaoyan Ju, Jing Lan, Qinyi Zhu, Xiaoyi Fang
Based on three annual waves of data obtained from 268 Chinese couples in the early years of marriage and using a three-wave, cross-lagged approach, the present study examined the associations among daily marital communication, marital conflict resolution, and marital quality. Results indicated unidirectional associations linking daily marital communication or marital conflict resolution to marital quality (instead of reciprocal associations); and when considered simultaneously in a single model, daily marital communication and marital conflict resolution explained variance in marital quality above and beyond each other...
May 17, 2018: Journal of Family Psychology: JFP
https://www.readbyqxmd.com/read/29771359/neural-bases-of-social-communicative-intentions-in-speech
#9
Nele Hellbernd, Daniela Sammler
Our ability to understand others' communicative intentions in speech is key to successful social interaction. Indeed, misunderstanding an "excuse me" as apology, while meant as criticism, may have important consequences. Recent behavioural studies have provided evidence that prosody, i.e., vocal tone, is an important indicator for speakers' intentions. Using a novel audio-morphing paradigm, the present fMRI study examined the neurocognitive mechanisms that allow listeners to 'read' speakers' intents from vocal-prosodic patterns...
May 16, 2018: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29770356/nonvolatile-infrared-memory-in-mos-2-pbs-van-der-waals-heterostructures
#10
Qisheng Wang, Yao Wen, Kaiming Cai, Ruiqing Cheng, Lei Yin, Yu Zhang, Jie Li, Zhenxing Wang, Feng Wang, Fengmei Wang, Tofik Ahmed Shifa, Chao Jiang, Hyunsoo Yang, Jun He
Optoelectronic devices for information storage and processing are at the heart of optical communication technology due to their significant applications in optical recording and computing. The infrared radiations of 850, 1310, and 1550 nm with low energy dissipation in optical fibers are typical optical communication wavebands. However, optoelectronic devices that could convert and store the infrared data into electrical signals, thereby enabling optical data communications, have not yet been realized. We report an infrared memory device using MoS2 /PbS van der Waals heterostructures, in which the infrared pulse intrigues a persistent resistance state that hardly relaxes within our experimental time scales (more than 104 s)...
April 2018: Science Advances
https://www.readbyqxmd.com/read/29763271/adults-with-developmental-disabilities-a-comprehensive-approach-to-medical-care
#11
Clarissa Kripke
Developmental disabilities are attributable to a cognitive impairment, physical impairment, or both. They manifest during the developmental period from birth to early adulthood, and are likely to continue indefinitely. The life expectancy of most persons with developmental disabilities now approaches that of the general population. According to the neurodiversity model of care, developmental disability is accepted as a valued part of human neurologic diversity. The social model focuses on improving participation in society with accommodations such as adaptive equipment or improvements to the social and physical environment...
May 15, 2018: American Family Physician
https://www.readbyqxmd.com/read/29762793/a-qualitative-study-of-the-communication-process-for-medical-acupuncture-in-family-medicine
#12
Christy J W Ledford, Carla L Fisher, Paul Crawford
BACKGROUND AND OBJECTIVES: As evidence establishes the efficacy of medical acupuncture, more family physicians and family medicine residents may receive medical acupuncture training and need to know how to effectively communicate about the treatment option with patients. By identifying how physicians talk about acupuncture treatment with their patients, we aimed to develop a model for physician training that could enhance their ability to integrate and practice medical acupuncture in conventional clinical settings...
May 2018: Family Medicine
https://www.readbyqxmd.com/read/29757818/surrogates-experiences-of-engaging-in-physician-orders-for-life-sustaining-treatment-discussions-for-persons-with-advanced-dementia
#13
Hyejin Kim, Christine Bradway, Susan E Hickman, Mary Ersek
BACKGROUND AND PURPOSE: Little is known about surrogates' experiences of engaging in Physician Orders for Life-Sustaining Treatment (POLST) discussions. This study describes family surrogates' experiences when engaging in POLST discussions with primary care providers. METHODS: Semistructured interviews were conducted with 10 family surrogates of individuals with advanced dementia who were enrolled in a Program of All-Inclusive Care for the Elderly or resided in a nursing home...
February 2018: Journal of the American Association of Nurse Practitioners
https://www.readbyqxmd.com/read/29755226/bioenergy-and-its-implication-for-yoga-therapy
#14
Chathapuram Rajan Narayanan, Konstantin Korotkov, Thaiyar Madabusi Srinivasan
Electro photonic imaging (EPI) is being researched relative to its application for yoga therapy. Three parameters of interest in EPI measurements are as follows: Communication energy (C), integral or normalized area (IA), and Entropy (E). It is important to note that C indicates the total energy of communication for the organ system; IA is an indication of total amount of energy that is available for the organ system while entropy is an indication of the amount of coherence of the energy. Coherence and entropy are inversely related; this means less the entropy, more the coherence and vice versa...
May 2018: International Journal of Yoga
https://www.readbyqxmd.com/read/29753862/new-insights-into-microglia-neuron-interactions-a-neuron-s-perspective
#15
REVIEW
Balázs Pósfai, Csaba Cserép, Barbara Orsolits, Ádám Dénes
Microglia are the primary immune cells of the central nervous system. However, recent data indicate that microglia also contribute to diverse physiological and pathophysiological processes that extend beyond immune-related functions and there is a growing interest to understand the mechanisms through which microglia interact with other cells in the brain. In particular, the molecular processes that contribute to microglia-neuron communication in the healthy brain and their role in common brain diseases have been intensively studied during the last decade...
May 10, 2018: Neuroscience
https://www.readbyqxmd.com/read/29753478/short-communication-development-of-an-equation-for-estimating-methane-emissions-of-dairy-cows-from-milk-fourier-transform-mid-infrared-spectra-by-using-reference-data-obtained-exclusively-from-respiration-chambers
#16
A Vanlierde, H Soyeurt, N Gengler, F G Colinet, E Froidmont, M Kreuzer, F Grandl, M Bell, P Lund, D W Olijhoek, M Eugène, C Martin, B Kuhla, F Dehareng
Evaluation and mitigation of enteric methane (CH4 ) emissions from ruminant livestock, in particular from dairy cows, have acquired global importance for sustainable, climate-smart cattle production. Based on CH4 reference measurements obtained with the SF6 tracer technique to determine ruminal CH4 production, a current equation permits evaluation of individual daily CH4 emissions of dairy cows based on milk Fourier transform mid-infrared (FT-MIR) spectra. However, the respiration chamber (RC) technique is considered to be more accurate than SF6 to measure CH4 production from cattle...
May 9, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29753181/weighted-regularized-statistical-shape-space-projection-for-breast-3d-model-reconstruction
#17
Guillermo Ruiz, Eduard Ramon, Jaime García, Federico M Sukno, Miguel A González Ballester
The use of 3D imaging has increased as a practical and useful tool for plastic and aesthetic surgery planning. Specifically, the possibility of representing the patient breast anatomy in a 3D shape and simulate aesthetic or plastic procedures is a great tool for communication between surgeon and patient during surgery planning. For the purpose of obtaining the specific 3D model of the breast of a patient, model-based reconstruction methods can be used. In particular, 3D morphable models (3DMM) are a robust and widely used method to perform 3D reconstruction...
May 2, 2018: Medical Image Analysis
https://www.readbyqxmd.com/read/29752645/a-tale-of-two-countries-innovation-and-collaboration-aimed-at-changing-the-culture-of-medicine-in-uruguay
#18
Juan J Dapueto, Mercedes Viera, Charles Samenow, William H Swiggart, Jeffrey Steiger
This is a case study of a program to address professionalism at the Universidad de la República in Uruguay. We describe a five-year ongoing international collaboration. Relevant characteristics of the context, the program components, activities, and results were analyzed. The expected outcomes were to introduce standards of professional practices in the curricula of medical students and residents and the implementation of a program that might lead to a significant change in the culture of medicine in the University...
May 11, 2018: HEC Forum: An Interdisciplinary Journal on Hospitals' Ethical and Legal Issues
https://www.readbyqxmd.com/read/29751558/connexin-communication-compartments-and-wound-repair-in-epithelial-tissue
#19
REVIEW
Marc Chanson, Masakatsu Watanabe, Erin M O'Shaughnessy, Alice Zoso, Patricia E Martin
Epithelial tissues line the lumen of tracts and ducts connecting to the external environment. They are critical in forming an interface between the internal and external environment and, following assault from environmental factors and pathogens, they must rapidly repair to maintain cellular homeostasis. These tissue networks, that range from a single cell layer, such as in airway epithelium, to highly stratified and differentiated epithelial surfaces, such as the epidermis, are held together by a junctional nexus of proteins including adherens, tight and gap junctions, often forming unique and localised communication compartments activated for localised tissue repair...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29749223/organic-electrochemical-transistors-for-the-detection-of-cell-surface-glycans
#20
Lizhen Chen, Ying Fu, Naixiang Wang, Anneng Yang, Yuanzhe Li, Jie Wu, Huangxian Ju, Feng Yan
Cell surface glycans play critical roles in diverse biological processes, such as cell-cell communication, immunity, infection, development and differentiation. Their expressions are closely related to cancer growth and metastasis. This work demonstrates an organic electrochemical transistor (OECT) -based biosensor for the detection of glycan expression on living cancer cells. Using mannose on human breast cancer cells (MCF-7) as a target model, the gate electrode of the OECT is modified with concanavalin A that can specifically bind cell surface mannose and capture the cancer cells...
May 11, 2018: ACS Applied Materials & Interfaces
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