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JOURNAL ARTICLE
Yashes Srinivasan, David Shamritsky, Asmita Bhatta, Ellaine Chou, Trang Pham, Yashi Sanghvi, Lily Woolf, Michael Zhang, Eseosa Odigie, Clemence Chidziva, Erasmus Muganda, Priscilla Zimani, Newton de Faria, Anaïs Rameau
IMPORTANCE: Endoscopes are paramount to the practice of otolaryngology. To provide physicians in low-middle-income countries with adequate tools to treat otolaryngologic problems, it is necessary to create a low-cost sustainable option. OBJECTIVE: To describe the design and usability of an open-source, low-cost flexible laryngoscope that addresses the lack of affordable and accessible methods for otolaryngologic visualization in resource-limited settings. DESIGN, SETTING, AND PARTICIPANTS: This quality improvement study used a mixed-methods approach, including a technical description of device design as well as quantitative and qualitative survey evaluation of device usability...
March 7, 2024: JAMA Otolaryngology—Head & Neck Surgery
#22
JOURNAL ARTICLE
Ravindran Revand, Aditya Dontham, Swarnabha Sarkar, Asmita Patil
Intravenous injection of capsaicin produces vagal-mediated protective cardio-pulmonary (CP) reflexes manifesting as tachypnea, bradycardia, and triphasic blood pressure (BP) response in anesthetized rats. Particulate matter from diesel engine exhaust has been reported to attenuate these reflexes. However, the effects of gaseous constituents of diesel exhaust are not known. Therefore, the present study was designed to investigate the effects of gaseous pollutants in diesel exhaust, on capsaicin-induced CP reflexes in rat model...
March 7, 2024: Cardiovascular Toxicology
#23
Asmita Pal, Soumee Sengupta, Rita Kundu
No abstract text is available yet for this article.
March 2, 2024: Journal of Ethnopharmacology
#24
JOURNAL ARTICLE
Filip Ionescu, Jerel C David, Apoorva Ravichandran, David A Sallman, Kendra Sweet, Rami S Komrokji, Onyee Chan, Andrew Kuykendall, Eric Padron, Rawan Faramand, Nelli Bejanyan, Farhad Khimani, Hany Elmariah, Joseph Pidala, Asmita Mishra, Lia Perez, Taiga Nishihori, Jeffrey E Lancet
BACKGROUND: Hypomethylating agent + venetoclax is an effective frontline combination for acute myeloid leukemia, but its efficacy and safety in post-allogeneic hematopoietic cell transplant (alloHCT) relapse remain underexplored. Outcomes have been poor for this population, with no standard treatment. PATIENTS AND METHODS: We retrospectively analyzed 72 Ven-naïve patients who received hypomethylating agents + venetoclax at relapse following alloHCT and aimed to evaluate the rates of complete remission with or without hematologic recovery (CR/CRi) and minimal residual disease (MRD) negativity, CR/CRi duration, and overall survival...
February 12, 2024: Clinical Lymphoma, Myeloma & Leukemia
#25
JOURNAL ARTICLE
Asmita Ghimire, Poonam Koirala, Hima Rijal, Anita Chamlagain, Padam Raj Pant
INTRODUCTION: Proteinuria is usually related with preeclampsia during pregnancy, although it can also be caused by other conditions such as renal disease or isolated proteinuria. Proteinuria during pregnancy can result in adverse fetomaternal outcomes. The study aimed to find the prevalence of proteinuria among pregnant women admitted to the Department of Obstetrics and Gynaecology of a tertiary care centre. METHODS: A descriptive cross-sectional study was carried out among pregnant women in the Department of Obstetrics and Gynaecology after obtaining ethical approval from the Institutional Review Committee...
January 2, 2024: JNMA; Journal of the Nepal Medical Association
#26
JOURNAL ARTICLE
Jemina Onimowo, Nino Dieseru, Asmita Chatterjee, Lewis Isaacs, Kirsty Ashton, Rosemary Medlock
No abstract text is available yet for this article.
November 2023: Future Healthcare Journal
#27
Souvik Mukherjee, Asmita Sakpal, Megha Mehrotra, Pratham Phadte, Bharat Rekhi, Pritha Ray
In the original publication [...].
February 6, 2024: Cancers
#28
JOURNAL ARTICLE
Asmita Kamble, Rajkumar Singh, Harinder Singh
Phytate, also known as myoinositol hexakisphosphate, exhibits anti-nutritional properties and possesses a negative environmental impact. Phytase enzymes break down phytate, showing potential in various industries, necessitating thorough biochemical and computational characterizations. The present study focuses on Obesumbacterium proteus phytase (OPP), indicating its similarities with known phytases and its potential through computational analyses. Structure, functional, and docking results shed light on OPP's features, structural stability, strong and stable interaction, and dynamic conformation, with flexible sidechains that could adapt to different temperatures or specific functions...
February 23, 2024: Molecular Biotechnology
#29
JOURNAL ARTICLE
Shraddha Paniya, Asmita Dileep Gaonkar, Kiran Vankayala
Hybrid water electrolysis (HyWES) with iodide oxidation as non-OER for energy-saving H2 production is demonstrated using self-supported sulfate ion modified Ni,Fe(oxy)hydroxide as the anode. The sulfate ions adsorbed on the catalyst show a promoting effect in achieving high electrochemical activity. The HyWES requires a voltage as low as 1.36 V to achieve the bechmark current density of 10 mA cm-2 .
February 23, 2024: Chemical Communications: Chem Comm
#30
REVIEW
Amit Mathur, Ritu, Prakash Chandra, Asmita Das
Autophagy, a highly regulated cellular process, assumes a dual role in the context of cancer. On the one hand, it functions as a crucial homeostatic pathway, responsible for degrading malfunctioning molecules and organelles, thereby maintaining cellular health. On the other hand, its involvement in cancer development and regression is multifaceted, contingent upon a myriad of factors. This review meticulously examines the intricacies of autophagy, from its molecular machinery orchestrated by Autophagy-Related Genes (ATG) initially discovered in yeast to the various modes of autophagy operative within cells...
March 2024: 3 Biotech
#31
JOURNAL ARTICLE
Loukas Ieremias, Mads H Kaspersen, Asmita Manandhar, Katrine Schultz-Knudsen, Christina Ioanna Vrettou, Rina Pokhrel, Christoffer V Heidtmann, Laura Jenkins, Christina Kanellou, Sara Marsango, Yueming Li, Hans Bräuner-Osborne, Elisabeth Rexen Ulven, Graeme Milligan, Trond Ulven
GPR84 is a putative medium-chain fatty acid receptor that is implicated in regulation of inflammation and fibrogenesis. Studies have indicated that GPR84 agonists may have therapeutic potential in diseases such as Alzheimer's disease, atherosclerosis, and cancer, but there is a lack of quality tool compounds to explore this potential. The fatty acid analogue LY237 ( 4a ) is the most potent GPR84 agonist disclosed to date but has unfavorable physicochemical properties. We here present a SAR study of 4a . Several highly potent agonists were identified with EC50 down to 28 pM, and with SAR generally in excellent agreement with structure-based modeling...
February 21, 2024: Journal of Medicinal Chemistry
#32
JOURNAL ARTICLE
Shweta Gulia, Prakash Chandra, Asmita Das
OBJECTIVE: The study aimed to explore the crucial genes involved in cancer-related biological processes, including EMT, autophagy, apoptosis, anoikis, and metastasis. It also sought to identify common genes among the pathways linked to these biological processes, determine the level of Bcl-2 expression in various types of cancers, and find a potent inhibitor of Bcl-2 among natural compounds. METHODS: Common genes involved in the pathways related to EMT, autophagy, apoptosis, anoikis, and metastasis were explored, and the level of the most frequently overexpressed gene that was Bcl-2, in various types of cancers was analyzed by gene expression analysis...
February 19, 2024: Current Computer-aided Drug Design
#33
JOURNAL ARTICLE
Asmita Dawadi, Manoj Humagain, Simant Lamichhane, Birat Sapkota
BACKGROUND: Excessive gingival display (EGD), also known as a gummy smile, is characterized by overexposure of the maxillary gingiva on smiling. EGD can cause embarrassment and reduce patient satisfaction. This study aimed to evaluate the clinical and psychological effects of lip repositioning surgery on the management of EGD. METHODOLOGY: This experimental study enrolled 14 patients with EGD who had undergone a modified lip repositioning technique, which comprised moving two strips of mucosa bilaterally to the maxillary labial frenum and repositioning the new mucosal margin coronally...
January 2024: Saudi Dental Journal
#34
JOURNAL ARTICLE
Shallu Dhingra, Santosh Prasad Gupta, Asmita Shah, Dharmendra Pratap Singh, Santanu Kumar Pal
π-Conjugated pyrene-thiophene-based room-temperature discotic liquid crystals armed with four peripheral aliphatic chains are reported to study their potential use in a hole-transporting organic semiconductor. The charge carrier mobility studies using the ToF method revealed room temperature hole mobility in the order of 10-4 cm2 V-1 s-1 for both mesogens. However, the mobility values for compound 1a were observed in the order of 10-3 cm2 V-1 s-1 at high temperatures. Such molecular systems can potentially be used in nonlinear organic electronic applications...
February 19, 2024: Chemical Communications: Chem Comm
#35
JOURNAL ARTICLE
Unraveling Dengue Dynamics: In-Depth Epidemiological and Entomological Analyses in Bengaluru, India.
Vani H C, Sujit Nath N, Jaiswal M K, Tiwari R P, Bharathi P, Asmita B, Shankar G, Jithen C, Pallavi V D, Srinivas V, Ashok M, Mahamood Shariff, Renuka S, Shrinivasa B M
In view of the increased number of detected dengue cases in Bengaluru, a request for situation analysis was received from local health authorities in the selected area. The study included epidemiological and entomological assessments to understand the same. The immature forms collected were allowed to emerge, pooled, and processed for vector incrimination. In the surveyed population (347), 20 (5.8%) reported fever cases and 12 (3.5%) were confirmed as dengue cases among the 102 families. Stegomyia indices were high...
2024: Journal of Tropical Medicine
#36
JOURNAL ARTICLE
Asmita Mishra, B C Meikap
The current study explores the co-pyrolysis of waste motor oil (WMO) and rice stubble in a designed lab-scale pyrolyzer to produce alternative energy fuels. The parameter screening was followed by optimization utilizing the Box-Behnken design (BBD). Reactor temperature (TR ), mixing ratio (M), and holding time (t) affected the co-pyro-oil yield substantially. A maximum co-pyro-oil yield of 90.3% was achieved at a TR = 485 °C, t = 12.5 min, and M = 5% rice stubble to waste motor oil, which was further characterized and compared with the commercial diesel fuel properties...
February 15, 2024: Chemosphere
#37
JOURNAL ARTICLE
Alexandra M Huddell, Resham Thapa, Guillermo S Marcillo, Lori J Abendroth, Victoria J Ackroyd, Shalamar D Armstrong, Gautam Asmita, Muthukumar V Bagavathiannan, Kipling S Balkcom, Andrea Basche, Shawn Beam, Kevin Bradley, Lucas Pecci Canisares, Heather Darby, Adam S Davis, Pratap Devkota, Warren A Dick, Jeffery A Evans, Wesley J Everman, Tauana Ferreira de Almeida, Michael L Flessner, Lisa M Fultz, Stefan Gailans, Masoud Hashemi, Joseph Haymaker, Matthew J Helmers, Nicholas Jordan, Thomas C Kaspar, Quirine M Ketterings, Eileen Kladivko, Alexandra Kravchenko, Eugene P Law, Lauren Lazaro, Ramon G Leon, Jeffrey Liebert, John Lindquist, Kristen Loria, Jodie M McVane, Jarrod O Miller, Michael J Mulvaney, Nsalambi V Nkongolo, Jason K Norsworthy, Binaya Parajuli, Christopher Pelzer, Cara Peterson, Hanna Poffenbarger, Pratima Poudel, Mark S Reiter, Matt Ruark, Matthew R Ryan, Spencer Samuelson, John E Sawyer, Sarah Seehaver, Lovreet S Shergill, Yogendra Raj Upadhyaya, Mark VanGessel, Ashley L Waggoner, John M Wallace, Samantha Wells, Charles White, Bethany Wolters, Alex Woodley, Rongzhong Ye, Eric Youngerman, Brian A Needelman, Steven B Mirsky
Winter cover crop performance metrics (i.e., vegetative biomass quantity and quality) affect ecosystem services provisions, but they vary widely due to differences in agronomic practices, soil properties, and climate. Cereal rye (Secale cereale) is the most common winter cover crop in the United States due to its winter hardiness, low seed cost, and high biomass production. We compiled data on cereal rye winter cover crop performance metrics, agronomic practices, and soil properties across the eastern half of the United States...
February 13, 2024: Scientific Data
#38
JOURNAL ARTICLE
Gaurav Kumar Chaubey, Radheshyam Modanwal, Rahul Dilawari, Sharmila Talukdar, Asmita Dhiman, Surbhi Chaudhary, Anil Patidar, Chaaya Iyengar Raje, Manoj Raje
Diabetes mellitus (DM) is a major risk factor for tuberculosis (TB), though the underlying mechanisms linking DM and TB remain ambiguous. Macrophages are a key player in the innate immune response and their phagocytic ability is enhanced in response to microbial infections. Upon infection or inflammation, they also repel invading pathogens by generating; reactive oxygen species (ROS), reactive nitrogen species (RNS), pro-inflammatory cytokines (IL-1β and IL-6), and anti-inflammatory cytokines (IL-10)...
February 12, 2024: Immunologic Research
#39
Kailash Mani Pokhrel, Popular Pokhrel, Utsha Mulmi, Kapil Khanal, Anup Panthi, Suraj Aryal, Asmita Ghimire
INTRODUCTION: Endometrial polyps (EPs) result from the overgrowth of endometrial glands and stroma. Giant endometrial polyps, defined as those exceeding 4 cm, are rare, and their association with phytoestrogen (PE) intake is infrequently reported. CASE PRESENTATION: The authors present a case of a giant endometrial polyp in a 59-year-old post-menopausal woman from Nepal. The patient presented with lower abdominal pain and a history of vaginal spotting. She was not under any drugs or medications, including hormones, but had a regular intake of PE-rich foods...
February 2024: Annals of Medicine and Surgery
#40
JOURNAL ARTICLE
Sananda Dey, Arun Mondal, Asmita Aash, Rimi Mukherjee, Soumya Kolay, Nensina Murmu, Nabendu Murmu, Biplab Giri, Mijanur Rahaman Molla
Breast cancer is the most prevalent and aggressive type of cancer, causing high mortality rates in women globally. Many drawbacks and side effects of the current chemotherapy force us to develop a robust chemotherapeutic system that can deal with off-target hazards and selectively combat cancer growth, invasiveness, and cancer-initiating cells. Here, a pH-responsive cross-linked nanocarrier (140-160 nm) endowed with poly-β-thioester functionality (CBAPTL) has been sketched and fabricated for noncovalent firm encapsulation of anticancer drug, parthenolide (PTL) at physiological pH (7...
February 7, 2024: ACS Applied Bio Materials
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