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https://www.readbyqxmd.com/read/28096464/functional-transformation-of-c-reactive-protein-by-hydrogen-peroxide
#1
Sanjay K Singh, Avinash Thirumalai, Asmita Pathak, Donald N Ngwa, Alok Agrawal
C-reactive protein (CRP) is present at sites of inflammation including amyloid plaques, atherosclerotic lesions and arthritic joints. CRP, in its native pentameric structural conformation, binds to cells and molecules which have exposed phosphocholine (PCh) groups. CRP, in its non-native pentameric structural conformation, binds to a variety of deposited, denatured and aggregated proteins, in addition to binding to PCh-containing substances. In this study, we investigated the effects of hydrogen peroxide (H2O2), a prototypical reactive oxygen species and which is also present at sites of inflammation, on the ligand recognition function of CRP...
January 17, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28073120/nano-pelargonidin-protects-hyperglycemic-induced-l6-cells-against-mitochondrial-dysfunction
#2
Asmita Samadder, Debojyoti Tarafdar, Suresh K Abraham, Kumaresh Ghosh, Anisur Rahman Khuda-Bukhsh
Nano-encapsulation of several natural products has become an important tool in enhancing the bioavailability of some modern drugs against many diseases. Pelargonidin is an anthocyanidin found in many fruits and vegetables. Pelargonidin is loaded with poly-lactide-co-glycolic-acid, a non-toxic biodegradable polymer, to produce nano-pelargonidin. Size, morphology, zeta potential, and planar uniformity of formulated nano-pelargonidin were determined by atomic force microscopy and dynamic light scattering. The time required for cellular entry, folds of nano-pelargonidin, and drug encapsulation efficiency of poly-lactide-co-glycolic-acid were also ascertained...
January 10, 2017: Planta Medica
https://www.readbyqxmd.com/read/28050458/congenital-cystic-adenomatoid-malformation-a-tertiary-care-hospital-experience
#3
Asmita Anilkumar Mehta, Naveen Viswanathan, Anil Kumar Vasudevan, Roopa Paulose, Mohan Abraham
INTRODUCTION: Congenital Cystic Adenomatoid Malformation (CCAM) is an uncommon developmental deformity affecting the terminal respiratory structures. It is characterized by broncho pulmonary foregut malformations. The reason behind it is an arrest in lung development between 4(th) and 7(th) week of fetal life. AIM: The present study was conducted to assess the clinical and radiological profile and also to study the role of surgical intervention in patients with CCAM...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27914571/evaluating-the-anticancer-activity-and-nanoparticulate-nature-of-homeopathic-preparations-of-terminalia-chebula
#4
Kirtee Wani, Nilesh Shah, Asmita Prabhune, Arun Jadhav, Prabhakar Ranjekar, Ruchika Kaul-Ghanekar
BACKGROUND: Breast cancer is the most common cancer diagnosed among women and is the second leading cause of cancer death. Homeopathic medicines are part of the alternative medicines that are given as a supportive therapy in breast cancer. The objective of this study was to investigate the anticancer activity of commercially available homeopathic preparations of Terminalia chebula (TC) and evaluate their nanoparticulate nature. METHODS: Mother tincture (MT) and other homeopathic preparations (3X, 6C and 30C) of TC were tested for their effect on the viability of breast cancer (MDAMB231 and MCF7) and non-cancerous (HEK 293) cell lines by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay...
November 2016: Homeopathy: the Journal of the Faculty of Homeopathy
https://www.readbyqxmd.com/read/27893464/the-h3k9-dimethyltransferases-ehmt1-2-protect-against-pathological-cardiac-hypertrophy
#5
Bernard Thienpont, Jan Magnus Aronsen, Emma Louise Robinson, Hanneke Okkenhaug, Elena Loche, Arianna Ferrini, Patrick Brien, Kanar Alkass, Antonio Tomasso, Asmita Agrawal, Olaf Bergmann, Ivar Sjaastad, Wolf Reik, Hywel Llewelyn Roderick
Cardiac hypertrophic growth in response to pathological cues is associated with reexpression of fetal genes and decreased cardiac function and is often a precursor to heart failure. In contrast, physiologically induced hypertrophy is adaptive, resulting in improved cardiac function. The processes that selectively induce these hypertrophic states are poorly understood. Here, we have profiled 2 repressive epigenetic marks, H3K9me2 and H3K27me3, which are involved in stable cellular differentiation, specifically in cardiomyocytes from physiologically and pathologically hypertrophied rat hearts, and correlated these marks with their associated transcriptomes...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27858017/iron-porphyrins-with-a-hydrogen-bonding-cavity-effect-of-weak-interactions-on-their-electronic-structure-and-reactivity
#6
Kaustuv Mittra, Asmita Singha, Abhishek Dey
The electronic structure and reactivity of iron porphyrin complexes bearing 2(nd) sphere hydrogen bonding residues have been investigated over the last few years. The presence of these weak interactions alters the spin ground state, and axial ligand bonding and provides a proton translocation pathway into the active site. Mechanistic investigations in organic as well as aqueous media demonstrate how controlled delivery of protons is fundamental in dictating the selectivity of a multi-electron multi-proton process like the reduction of dioxygen to water...
November 18, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/27854038/biosynthesis-of-glycomonoterpenes-to-attenuate-quorum-sensing-associated-virulence-in-bacteria
#7
Amrita Patil, Kasturi Joshi-Navre, Ruchira Mukherji, Asmita Prabhune
The acquisition of multidrug resistance in bacteria has become a bigger threat of late, mainly due to the bacterial signaling phenomenon, quorum sensing (QS). QS, among a population of bacteria, initiates the formation of biofilms and offers myriad advantages to bacteria. Burgeoning antibiotic resistance in biofilm-producing bacteria has motivated efforts toward finding new alternatives to these traditional antimicrobials. In the present study, we report the increased solubility and additional quorum quenching as well as biofilm disruption activity of glyco-derivatives of monoterpenes (citral and citronellal)...
November 16, 2016: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/27819360/an-active-igf-1r-akt-signaling-imparts-functional-heterogeneity-in-ovarian-csc-population
#8
Ram K Singh, Ajit Dhadve, Asmita Sakpal, Abhijit De, Pritha Ray
Deregulated IGF-1R-AKT signaling influences multiple nodes of cancer cell physiology and assists in migration, metastasis and acquirement of radio/chemoresistance. Enrichment of cancer stem cells (CSC) positively correlates with radio/chemoresistance development in various malignancies. It is unclear though, how IGF-1R-AKT signalling shapes CSC functionality especially in ovarian cancer. Previously we showed that upregulated IGF-1R expression is essential to initiate platinum-taxol resistance at early stage which declines with elevated levels of activated AKT at late resistant stage in ovarian cancer cells...
November 7, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27806027/traditional-chinese-medicine-practitioners-in-new-zealand-differences-associated-with-being-a-practitioner-in-new-zealand-compared-to-china
#9
Asmita Patel, Vahideh Toossi
AIMS: While New Zealand has experienced an increase in the use of traditional Chinese medicine (TCM) based acupuncture, very little is known about the practitioners who provide this type of treatment modality. Therefore, this study was designed to identify differences associated with being a TCM practitioner in New Zealand compared to China. METHODS: Ten Auckland-based TCM practitioners were individually interviewed. The interview schedule comprised of questions that were designed to identify any potential differences in practising TCM in New Zealand compared to China...
October 28, 2016: New Zealand Medical Journal
https://www.readbyqxmd.com/read/27796492/coccinia-grandis-l-voigt-leaf-extract-exhibits-antileishmanial-effect-through-pro-inflammatory-response-an-in-vitro-study
#10
Asmita Pramanik, Dibyendu Paik, Kshudiram Naskar, Tapati Chakraborti
The conventional drugs used for the treatment of human visceral leishmaniasis have concerns about the toxicity and most importantly parasite resistance. To overcome these troubles, more efforts are made for the development of innovative therapeutic agents having effective antileishmanial activity and simultaneously stimulate adaptive immune system of host cells. Hence, search for new leishmanicidal from the natural origin like plants has shown its effectiveness for the treatment of this tropical disease. The aim of this study is to investigate and characterize the antileishmanial efficacy of Coccinia grandis (L...
January 2017: Current Microbiology
https://www.readbyqxmd.com/read/27758862/phosphorylation-of-cytochrome-c-threonine-28-regulates-electron-transport-chain-activity-in-kidney-implications-for-amp-kinase
#11
Gargi Mahapatra, Ashwathy Varughese, Qinqin Ji, Icksoo Lee, Jenney Liu, Asmita Vaishnav, Christopher Sinkler, Alexandr A Kapralov, Carlos T Moraes, Thomas H Sanderson, Timothy L Stemmler, Lawrence I Grossman, Valerian E Kagan, Joseph S Brunzelle, Arthur R Salomon, Brian F P Edwards, Maik Hüttemann
Mammalian cytochrome c (Cytc) plays a key role in cellular life and death decisions, functioning as an electron carrier in the electron transport chain and as a trigger of apoptosis when released from the mitochondria. However, its regulation is not well understood. We show that the major fraction of Cytc isolated from kidneys is phosphorylated on Thr(28), leading to a partial inhibition of respiration in the reaction with cytochrome c oxidase. To further study the effect of Cytc phosphorylation in vitro, we generated T28E phosphomimetic Cytc, revealing superior behavior regarding protein stability and its ability to degrade reactive oxygen species compared with wild-type unphosphorylated Cytc Introduction of T28E phosphomimetic Cytc into Cytc knock-out cells shows that intact cell respiration, mitochondrial membrane potential (ΔΨm), and ROS levels are reduced compared with wild type...
January 6, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27722489/the-role-of-sequence-in-altering-the-unfolding-pathway-of-an-rna-pseudoknot-a-steered-molecular-dynamics-study
#12
Asmita Gupta, Manju Bansal
Mechanical unfolding studies on Ribonucleic Acid (RNA) structures are a subject of tremendous interest as they shed light on the principles of higher order assembly of these structures. Pseudoknotting is one of the most elementary ways in which this higher order assembly is achieved as discrete secondary structural units in RNA are brought in close proximity to form a tertiary structure. Using steered molecular dynamics (SMD) simulations, we have studied the unfolding of five RNA pseudoknot structures that differ from each other either by base substitutions in helices or loops...
October 10, 2016: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/27715454/diverse-profiles-of-n-acyl-homoserine-lactones-in-biofilm-forming-strains-of-cronobacter-sakazakii
#13
Niharika Singh, Amrita Patil, Asmita Prabhune, Mamta Raghav, Gunjan Goel
The present study investigates the role of quorum sensing (QS) molecules expressed by C. sakazakii in biofilm formation and extracellular polysaccharide expression. The QS signaling was detected using Chromobacterium violaceum 026 and Agrobacterium tumefaciens NTL4(pZLR4) based bioassay. Long chain N-acyl-homoserine lactones (AHLs) with C6- C18 chain length were identified using High Performance Liquid Chromatography and Liquid Chromatography-High Resolution Mass Spectrometry. A higher Specific Biofilm Formation (SBF) index (p < 0...
October 7, 2016: Virulence
https://www.readbyqxmd.com/read/27678144/bladder-rupture-with-incomplete-rupture-of-the-uterus
#14
Robin Medhi, Asmita Mishra, Jatinkumar Vishnubhai Patel
No abstract text is available yet for this article.
September 27, 2016: International Urogynecology Journal
https://www.readbyqxmd.com/read/27660169/nonfluorodeoxyglucose-avid-persistent-splenomegaly-at-time-of-transplantation-delays-neutrophil-and-platelets-engraftment-without-affecting-survival-in-patients-with-lymphomas-undergoing-allogeneic-hematopoietic-cell-transplantation
#15
Farhad Khimani, Daniel K Jeong, Branko Miladinovic, Taiga Nishihori, Ernesto Ayala, Frederick Locke, Asmita Mishra, Julio Chavez, Bijal Shah, Kenneth Gage, Mohamed A Kharfan-Dabaja
It is unclear if persistent splenomegaly in the presence of a negative positron emission tomography (PET) scan before allogeneic hematopoietic cell transplantation (HCT) influences post-transplantation outcomes in patients with lymphoma. We retrospectively reviewed records of 152 patients who underwent allogeneic HCT for various lymphomas. Centralized review of pretransplantation computed tomography (CT) and PET images was performed. Spleen volume (SV) was measured using the freehand volume segmentation tool in AW Workstation software (General Electric, Waukesha, WI)...
September 19, 2016: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/27660080/impact-of-routine-surveillance-imaging-on-outcomes-of-patients-with-diffuse-large-b-cell-lymphoma-after-autologous-hematopoietic-cell-transplantation
#16
Narendranath Epperla, Namrata Shah, Mehdi Hamadani, Kristin Richardson, Jonathan T Kapke, Asmita Patel, Sravanthi P Teegavarapu, George Carrum, Parameswaran N Hari, Sai R Pingali, Reem Karmali, Timothy S Fenske
BACKGROUND: For patients with relapsed or refractory diffuse large B-cell lymphoma (DLBCL), autologous hematopoietic cell transplantation (auto-HCT) is commonly used. After auto-HCT, DLBCL patients are often monitored with surveillance imaging. However, there is little evidence to support this practice. PATIENTS AND METHODS: We performed a multicenter retrospective study of DLBCL patients who underwent auto-HCT (n = 160), who experienced complete remission after transplantation, and who then underwent surveillance imaging...
December 2016: Clinical Lymphoma, Myeloma & Leukemia
https://www.readbyqxmd.com/read/27643890/silk-fibroin-sophorolipid-gelation-deciphering-the-underlying-mechanism
#17
Parul Dubey, Sugam Kumar, Vinod K Aswal, Sapna Ravindranathan, Pattuparambil R Rajamohanan, Asmita Prabhune, Anuya Nisal
Silk fibroin (SF) protein, produced by silkworm Bombyx mori, is a promising biomaterial, while sophorolipid (SL) is an amphiphilic functional biosurfactant synthesized by nonpathogenic yeast Candida bombicola. SL is a mixture of two forms, acidic (ASL) and lactonic (LSL), which when added to SF results in accelerated gelation of silk fibroin. LSL is known to have multiple biological functionalities and hence hydrogels of these green molecules have promising applications in the biomedical sector. In this work, SANS, NMR, and rheology are employed to examine the assembling properties of individual and mixed SLs and their interactions with SF to understand the mechanism that leads to rapid gelation...
October 10, 2016: Biomacromolecules
https://www.readbyqxmd.com/read/27630859/bilateral-xanthogranulomatous-orchiepididymitis-in-a-diabetic-patient
#18
Asmita Parihar, Sonal Sharma
No abstract text is available yet for this article.
July 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27578948/persistent-left-upper-lobe-opacity-in-middle-aged-gentleman
#19
Rajesh Venkitakrishnan, Kallikunnel Sayed Mohamed Aziz, Asmita Mehta
No abstract text is available yet for this article.
July 2016: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/27533914/understanding-nucleosomal-histone-and-dna-interactions-a-biophysical-study
#20
Chabita Saha, Rahul Kumar, Asmita Das
Histones are associated with DNA to form nucleosome essential for chromatin structure and major nuclear processes like gene regulation and expression. Histones consist of H1, H2A, H2B and H3, H4 type proteins. In the present study combined histones from calf thymus were complexed with ct DNA and their binding affinities were measured fluorimetrically. All the five histones were resolved on SDS page and their binding with DNA was visualised. The values of biding affinities varied with pH and salt concentration...
August 17, 2016: Journal of Biomolecular Structure & Dynamics
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