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https://www.readbyqxmd.com/read/29784017/investigating-aquifer-contamination-and-groundwater-quality-in-eastern-terai-region-of-nepal
#1
Sanjay Mahato, Asmita Mahato, Pankaj Kumar Karna, Nisha Balmiki
OBJECTIVE: This study aims at assessing the groundwater quality of the three districts of Eastern Terai region of Nepal viz. Morang, Jhapa, Sunsari using physicochemical characteristics and statistical approach so that possible contamination of water reservoir can be understood. pH, temperature, conductivity, turbidity, color, total dissolved solids, fluorides, ammonia, nitrates, chloride, total hardness, calcium hardness, calcium, magnesium, total alkalinity, iron, manganese, arsenic have to be analyzed to know the present status of groundwater quality...
May 21, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29723040/role-of-the-blood-coagulation-cascade-in-hepatic-fibrosis
#2
Asmita Pant, Anna K Kopec, James P Luyendyk
Liver is the primary source of numerous proteins critical for normal function of the blood coagulation cascade. Because of this, diseases of the liver, particularly when affiliated with severe complications like cirrhosis, are associated with abnormalities of blood clotting. Although conventional interpretation has inferred cirrhosis as a disorder of uniform bleeding risk, it is now increasingly appreciated as a disease wherein the coagulation cascade is precariously rebalanced. Moreover, prothrombotic risk factors are also associated with a more rapid progression of fibrosis in humans, suggesting that coagulation proteases participate in disease pathogenesis...
May 3, 2018: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/29717300/an-unusual-case-of-acute-abdomen-ovarian-vein-thrombosis
#3
Asmita Ghimire, Meeta Singh, Kesang Dikki Bista, Neebha Ojha, Sunita Bajracharya, Neeta Katuwal
Ovarian vein thrombosis is one of the rare causes for acute abdomen. Occult presentation of this disease may lead to diagnostic dilemma. A sixteen years female who was operated as a case of ectopic pregnancy was finally diagnosed as having ovarian vein thrombosis. She was successfully treated with anticoagulant.
March 13, 2018: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/29695981/cardiac-restoration-stemming-from-the-placenta-tree-insights-from-fetal-and-perinatal-cell-biology
#4
REVIEW
Sveva Bollini, Antonietta R Silini, Asmita Banerjee, Susanne Wolbank, Carolina Balbi, Ornella Parolini
Efficient cardiac repair and ultimate regeneration still represents one of the main challenges of modern medicine. Indeed, cardiovascular disease can derive from independent conditions upsetting heart structure and performance: myocardial ischemia and infarction (MI), pharmacological cardiotoxicity, and congenital heart defects, just to name a few. All these disorders have profound consequences on cardiac tissue, inducing the onset of heart failure over time. Since the cure is currently represented by heart transplantation, which is extremely difficult due to the shortage of donors, much effort is being dedicated to developing innovative therapeutic strategies based on stem cell exploitation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29670210/phase-i-trial-of-histone-deacetylase-inhibitor-panobinostat-in-addition-to-glucocorticoids-for-primary-therapy-of-acute-graft-versus-host-disease
#5
Lia Perez, Hugo Fernandez, Pedro Horna, Marcie Riches, Frederick Locke, Teresa Field, John Powers, Eva Sahakian, Alejandro Villagra, Asmita Mishra, Brian Betts, Mohamed Kharfan-Dabaja, Francisca Beato, Leonel Ochoa-Bayona, Joseph Pidala, Claudio Anasetti
Glucocorticoids for primary therapy of acute GVHD have limited responses. A phase I/II trial tested 4 weeks of deacetylase inhibitor panobinostat started within 48 h of glucocorticoids (1 mg/kg/day prednisone or equivalent) as primary treatment for patients with either classic acute GVHD (n = 16) or acute GVHD overlapping with chronic (n = 6). Four patients received 2.5 mg/m2 IV three times a week (TIW). Subsequent to discontinuation of IV panobinostat, patients received oral doses (PO). Two patients treated with 10 mg TIW (PO level 1) had progressive GVHD, after which patients were treated with 5 mg TIW (PO level -1; n = 16); 31/41 adverse events were possibly related, including thrombocytopenia (n = 13), leukopenia (n = 7), hypercholesterolemia (n = 3), hypertriglyceridemia (n = 5), anemia (n = 1), fatigue (n = 1), and hepatobiliary disorder (n = 1)...
April 18, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29645002/proteomics-analysis-reveals-a-potential-new-target-protein-for-the-lipid-lowering-effect-of-berberine8998
#6
Cheng-Yin Yu, Gang-Yi Liu, Xiao-Hui Liu, Yu-Zhou Gui, Hai-Ming Liu, Hong-Chao Zheng, Darek C Gorecki, Asmita V Patel, Chen Yu, Yi-Ping Wang
Berberine8998 is a newly synthesized berberine derivative with better lipid-lowering activity and improved absorption. The objective of this study was to investigate the effects of berberine8998 on serum cholesterol and lipid levels in vivo and to examine the mechanisms involved. Hamsters on high-fat diet (HFD) were administered berberine or berberine8998 (50 mg·kg-1 ·d-1 , ig) for 3 weeks. Berberine8998 administration significantly lowered the total cholesterol, triglycerides and LDL-C levels in HFD hamsters...
April 12, 2018: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/29623853/repositioning-of-difluorinated-propanediones-as-inhibitors-of-histone-methyltransferases-and-their-biological-evaluation-in-human-leukemic-cell-lines
#7
Tanushree Pal, Asmita Sharda, Bharat Khade, C S Ramaa, Sanjay Gupta
Cancer chemotherapy is associated with limitations like dose dependent host-tissue toxicity, multiple drug resistance and tumor heterogeneity. Hence, it is imperative to unearth novel targets to cure cancer. At present, 'pharmaco-epigenomics' constitutes the hope in cancer treatment owing to epigenetic deregulation- a reversible process, suspected of playing a role in malignancy. In this research work, we have used the fundamentals of drug repurposing for a set of our previously synthesized difluorinated propanediones and evaluated them for their histone methyltransferase inhibitory potential in leukemic cell lines...
April 4, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29621315/molecular-evolution-of-dnmt1-in-vertebrates-duplications-in-marsupials-followed-by-positive-selection
#8
David Alvarez-Ponce, María Torres-Sánchez, Felix Feyertag, Asmita Kulkarni, Taylen Nappi
DNA methylation is mediated by a conserved family of DNA methyltransferases (Dnmts). The human genome encodes three active Dnmts (Dnmt1, Dnmt3a and Dnmt3b), the tRNA methyltransferase Dnmt2, and the regulatory protein Dnmt3L. Despite their high degree of conservation among different species, genes encoding Dnmts have been duplicated and/or lost in multiple lineages throughout evolution, indicating that the DNA methylation machinery has some potential to undergo evolutionary change. However, little is known about the extent to which this machinery, or the methylome, varies among vertebrates...
2018: PloS One
https://www.readbyqxmd.com/read/29607832/morphological-and-dimensional-characteristics-of-dental-arch-in-children-with-beta-thalassemia-major
#9
Disha Kumar, Anant Gopal Nigam, Nikhil Marwah, Puneet Goenka, Asmita Sharma
Background and Objectives: The aim of this study was to examine the arch dimensions of beta thalassemia major patients in comparison with normal individuals. Materials and Methods: Dental arch dimensions were compared between thalassemic patients and normal individuals in the age group of 12-16 years in the maxillary and mandibular arch corresponding to each other regarding age, sex and Angle's molar relationship. A total number of sixty cases in each group were taken...
January 2018: Journal of the Indian Society of Pedodontics and Preventive Dentistry
https://www.readbyqxmd.com/read/29562784/cellular-and-site-specific-mitochondrial-characterization-of-vital-human-amniotic-membrane
#10
Asmita Banerjee, Andrea Lindenmair, Simone Hennerbichler, Philipp Steindorf, Ralf Steinborn, Andrey V Kozlov, Heinz Redl, Susanne Wolbank, Adelheid Weidinger
Over a century ago, clinicians started to use the human amniotic membrane for coverage of wounds and burn injuries. To date, literally thousands of different clinical applications exist for this biomaterial almost exclusively in a decellularized or denuded form. Recent reconsiderations for the use of vital human amniotic membrane for clinical applications would take advantage of the versatile cells of embryonic origin including the entirety of their cell organelles. Recently, more and more evidence was found, showing mitochondria to be involved in most fundamental cellular processes, such as differentiation and cell death...
January 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29515826/photophysical-studies-on-curcumin-sophorolipid-nanostructures-applications-in-quorum-quenching-and-imaging
#11
Sahana Vasudevan, Asmita A Prabhune
Sophorolipid biosurfactants are biodegradable, less toxic and FDA approved. The purified acidic form of sophorolipid is stimuli-responsive with self-assembling properties and used for solubilizing hydrophobic drugs. This study encapsulated curcumin (CU) with acidic sophorolipid (ASL) micelles and analysed using photophysical studies like UV-visible spectroscopy, photoluminescence (PL) spectroscopy and time-correlated single photon counting (TCSPC). TEM images have revealed ellipsoid micelles of approximately 100 nm size and were confirmed by dynamic light scattering...
February 2018: Royal Society Open Science
https://www.readbyqxmd.com/read/29499904/the-hungarian-initiative-for-ayurveda-european-institute-of-ayurvedic-sciences
#12
Asmita Wele
No abstract text is available yet for this article.
February 27, 2018: Journal of Ayurveda and Integrative Medicine
https://www.readbyqxmd.com/read/29459887/role-of-brca-mutations-in-the-modulation-of-response-to-platinum-therapy
#13
REVIEW
Sanghamitra Mylavarapu, Asmita Das, Monideepa Roy
Recent years have seen cancer emerge as one of the leading cause of mortality worldwide with breast cancer being the second most common cause of death among women. Individuals harboring BRCA mutations are at a higher risk of developing breast and/or ovarian cancers. This risk is much greater in the presence of germline mutations. BRCA1 and BRCA2 play crucial role in the DNA damage response and repair pathway, a function that is critical in preserving the integrity of the genome. Mutations that interfere with normal cellular function of BRCA not only lead to onset and progression of cancer but also modulate therapy outcome of treatment with platinum drugs...
2018: Frontiers in Oncology
https://www.readbyqxmd.com/read/29454747/plasminogen-activator-inhibitor-1-reduces-tissue-type-plasminogen-activator-dependent-fibrinolysis-and-intrahepatic-hemorrhage-in-experimental-acetaminophen-overdose
#14
Asmita Pant, Anna K Kopec, Kevin S Baker, Holly Cline-Fedewa, Daniel A Lawrence, James P Luyendyk
Acetaminophen (APAP)-induced liver injury in mice is associated with activation of the coagulation cascade and deposition of fibrin in liver. Plasminogen activator inhibitor-1 (PAI-1) is an important physiological inhibitor of tissue-type plasminogen activator (tPA) and plays a critical role in fibrinolysis. PAI-1 expression is increased in both experimental APAP-induced liver injury and patients with acute liver failure. Prior studies have shown that PAI-1 prevents intrahepatic hemorrhage and mortality after APAP challenge, but the downstream mechanisms are not clear...
May 2018: American Journal of Pathology
https://www.readbyqxmd.com/read/29442084/comparative-evaluation-of-antiplaque-and-antigingivitis-effects-of-an-herbal-and-chlorine-dioxide-mouthwashes-a-clinicomicrobiological-study
#15
Srinivasa T Siddeshappa, Shruti Bhatnagar, Ramreddy K Yeltiwar, Humera Parvez, Asmita Singh, Saket Banchhor
Aim: The aim of the present study was to compare the efficacy of herbal mouthwash and chlorine dioxide mouthwash in reduction of plaque and gingivitis. Settings and Design: In a randomized clinical trial, forty patients were randomly selected and divided equally into two groups. Materials and Methods: After professional oral prophylaxis, the clinical parameters plaque index, gingival index, and modified sulcular bleeding index were recorded at baseline, 7th day, 14th day, and 21st day...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29382819/rassf1a-uncouples-wnt-from-hippo-signalling-and-promotes-yap-mediated-differentiation-via-p73
#16
Angelos Papaspyropoulos, Leanne Bradley, Asmita Thapa, Chuen Yan Leung, Konstantinos Toskas, Delia Koennig, Dafni-Eleftheria Pefani, Cinzia Raso, Claudia Grou, Garth Hamilton, Nikola Vlahov, Anna Grawenda, Syed Haider, Jagat Chauhan, Ludovico Buti, Alexander Kanapin, Xin Lu, Francesca Buffa, Grigory Dianov, Alex von Kriegsheim, David Matallanas, Anastasia Samsonova, Magdalena Zernicka-Goetz, Eric O'Neill
Transition from pluripotency to differentiation is a pivotal yet poorly understood developmental step. Here, we show that the tumour suppressor RASSF1A is a key player driving the early specification of cell fate. RASSF1A acts as a natural barrier to stem cell self-renewal and iPS cell generation, by switching YAP from an integral component in the β-catenin-TCF pluripotency network to a key factor that promotes differentiation. We demonstrate that epigenetic regulation of the Rassf1A promoter maintains stemness by allowing a quaternary association of YAP-TEAD and β-catenin-TCF3 complexes on the Oct4 distal enhancer...
January 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29287899/strategizing-for-the-purification-of-a-multiple-big-domain-containing-protein-in-native-conformation-is-worth-it
#17
Asmita D Pawar, Deepshikha Verma, Venu Sankeshi, Rajeev Raman, Yogendra Sharma
The reliability and accuracy of conformational or functional studies of any novel multidomain protein rely on the quality of protein. The bottleneck in structural studies with the complete Big_2 domain containing proteins like LigA, LigB or MpIBP is usually their large molecular size owing to their multidomain (>10-12 domains) architectures. Interestingly, a soil bacterium Paenarthrobacter aurescens TC1, harbours a gene that encodes a protein comprising of four predicted Big_2 domains. We report here the expression and purification of this novel, multiple Big_2 domains containing protein, Arig of P...
May 2018: Protein Expression and Purification
https://www.readbyqxmd.com/read/29243556/preferences-of-aaa-aag-codon-recognition-by-modified-nucleosides-%C3%AF-m-5-s-2-u-34-and-t-6-a-37-present-in-trna-lys
#18
Kailas D Sonawane, Asmita S Kamble, Prayagraj M Fandilolu
Deficiency of 5-taurinomethyl-2-thiouridine, τm5 s2 U at the 34th 'wobble' position in tRNALys causes MERRF (Myoclonic Epilepsy with Ragged Red Fibers), a neuromuscular disease. This modified nucleoside of mt tRNALys , recognizes AAA/AAG codons during protein biosynthesis process. Its preference to identify cognate codons has not been studied at the atomic level. Hence, multiple MD simulations of various molecular models of anticodon stem loop (ASL) of mt tRNALys in presence and absence of τm5 s2 U34 and N6 -threonylcarbamoyl adenosine (t6 A37 ) along with AAA and AAG codons have been accomplished...
December 27, 2017: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/29242294/-in-vivo-il-12-il-23p40-neutralization-blocks-th1-th17-response-after-allogeneic-hematopoietic-cell-transplantation
#19
Joseph Pidala, Francisca Beato, Jongphil Kim, Brian Betts, Heather Jim, Elizabeth Sagatys, John E Levine, James L M Ferrara, Umut Ozbek, Ernesto Ayala, Marco Davila, Hugo F Fernandez, Teresa Field, Mohamed A Kharfan-Dabaja, Divis Khaira, Farhad Khimani, Frederick L Locke, Asmita Mishra, Michael Nieder, Taiga Nishihori, Lia Perez, Marcie Riches, Claudio Anasetti
T-helper 1 and T-helper 17 lymphocytes mediate acute graft- versus -host disease (GvHD). Interleukin 12 is critical for T-helper 1 differentiation and interleukin 23 for T-helper 17 maintenance. Interleukin 12 and 23 are heterodimeric cytokines that share the p40 subunit (IL-12/IL-23p40). In a randomized, blinded, placebo-controlled trial, we examined the biological impact and clinical outcomes following IL-12/IL-23p40 neutralization using ustekinumab. Thirty patients received peripheral blood mobilized hematopoietic cell transplantation (HCT) from HLA-matched sibling or unrelated donors, received sirolimus plus tacrolimus as GvHD prophylaxis, and were randomized to ustekinumab versus placebo with 1:1 allocation after stratification by donor type...
March 2018: Haematologica
https://www.readbyqxmd.com/read/29206915/phylogenetic-distribution-of-cmp-neu5ac-hydroxylase-cmah-the-enzyme-synthetizing-the-proinflammatory-human-xenoantigen-neu5gc
#20
Sateesh Peri, Asmita Kulkarni, Felix Feyertag, Patricia M Berninsone, David Alvarez-Ponce
The enzyme CMP-N-acetylneuraminic acid hydroxylase (CMAH) is responsible for the synthesis of N-glycolylneuraminic acid (Neu5Gc), a sialic acid present on the cell surface proteins of most deuterostomes. The CMAH gene is thought to be present in most deuterostomes, but it has been inactivated in a number of lineages, including humans. The inability of humans to synthesize Neu5Gc has had several evolutionary and biomedical implications. Remarkably, Neu5Gc is a xenoantigen for humans, and consumption of Neu5Gc-containing foods, such as red meats, may promote inflammation, arthritis, and cancer...
January 1, 2018: Genome Biology and Evolution
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