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https://www.readbyqxmd.com/read/28498623/interplay-of-electronic-cooperativity-and-exchange-coupling-in-regulating-the-reactivity-of-diiron-iv-oxo-complexes-towards-c-h-and-o-h-bond-activation
#1
Gopalan Rajaraman, Azaj Ansari, Asmita Singha, Mursaleem Ansari
Activation of inert C-H bonds such as those of methane are extremely challenging for chemists but in the nature, soluble methane monooxygenase enzyme readily oxidize methane to methanol using a diiron(IV) species. This has prompted chemists to look for similar model systems. Recently a (μ-oxo)bis(μ-carboxamido)diiron(IV) ([Fe(IV)2O(L)2]2+ L= N,N-bis-(3',5'-dimethyl-4'-methoxypyridyl-2'-methyl)-N'-acetyl- 1,2-diaminoethane) complex has been generated via bulk electrolysis and this species activates an inert C-H bond almost 1000 times faster compared to mononuclear Fe(IV)=O species and at the same time selectively activates O-H bonds of alcohols...
May 12, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28456117/correlation-of-binding-efficacies-of-dna-to-flavonoids-and-their-induced-cellular-damage
#2
Asmita Das, Debashis Majumder, Chabita Saha
Flavonoids are dietary intakes which are bestowed with several health benefits. The most studied property of flavonoids is their antioxidant efficacy. Among the chosen flavonoids Quercetin, Kaempferol and Myricetin is catagorized as flavonols whereas Apigenin and Luteolin belong to the flavone group. In the present study anti-cancer properties of flavonoids are investigated on the basis of their binding efficacy to ct-DNA and their ability to induce cytotoxicity in K562 leukaemic cells. The binding affinities of the flavonoids with calf thymus DNA (ct-DNA) are in the order Quercetin>Myricetin>Luteolin>Kaempferol>Apigenin...
April 19, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28453549/idiosyncratic-recognition-of-uug-uua-codons-by-modified-nucleoside-5-taurinomethyluridine-%C3%AF-m5u-present-at-wobble-position-in-anticodon-loop-of-trnaleu-a-molecular-modeling-approach
#3
Asmita S Kamble, Prayagraj M Fandilolu, Susmit B Sambhare, Kailas D Sonawane
Lack of naturally occurring modified nucleoside 5-taurinomethyluridine (τm5U) at the 'wobble' 34th position in tRNALeu causes mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). The τm5U34 specifically recognizes UUG and UUA codons. Structural consequences of τm5U34 to read cognate codons have not been studied so far in detail at the atomic level. Hence, 50ns multiple molecular dynamics (MD) simulations of various anticodon stem loop (ASL) models of tRNALeu in presence and absence of τm5U34 along with UUG and UUA codons were performed to explore the dynamic behaviour of τm5U34 during codon recognition process...
2017: PloS One
https://www.readbyqxmd.com/read/28446829/experimental-evaluation-of-hi%C3%A1-gv%C3%A4-di-gh%C3%A1-ta-in-behavioral-despair-using-animal-models
#4
Poonam Ashish Gupte, Jayshree Dawane, Asmita Ashish Wele
CONTEXT: Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side effects. Hence, it is imperative to search in Ayurveda for leads. AIM: To evaluate Anti- depressant activity of Hiṅgvādi Ghṛta in vivo ...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28419101/anti-proliferative-effect-of-novel-primary-cetyl-alcohol-derived-sophorolipids-against-human-cervical-cancer-cells-hela
#5
Laxman Nawale, Parul Dubey, Bhushan Chaudhari, Dhiman Sarkar, Asmita Prabhune
Sophorolipids (SLs) are glycolipid biosurfactants that have been shown to display anticancer activity. In the present study, we report anti-proliferative studies on purified forms of novel SLs synthesized using cetyl alcohol as the substrate (referred as SLCA) and their anticancer mechanism in human cervical cancer cells. Antiproliferative effect of column purified SLCA fractions (A, B, C, D, E and F) was examined in panel of human cancer cell lines as well as primary cells. Among these fractions, SLCA B and C significantly inhibited the survival of HeLa and HCT 116 cells without affecting the viability of normal human umbilical vein endothelial cells (HUVEC)...
2017: PloS One
https://www.readbyqxmd.com/read/28412693/feeding-angptl4-mice-trans-fat-promotes-foam-cell-formation-in-mesenteric-lymph-nodes-without-leading-to-ascites
#6
Antwi Boasiako Oteng, Asmita Bhattacharya, Susanne Brodesser, Ling Qi, Nguan Soon Tan, Sander Kersten
ANGPTL4 regulates plasma triglyceride levels by inhibiting lipoprotein lipase. Inactivation of ANGPTL4 decreases plasma triglycerides and reduces risk of coronary artery disease. Unfortunately, targeting ANGPTL4 for the therapeutic management of dyslipidemia and atherosclerosis is hampered by the observation that mice and monkeys in which ANGPTL4 is inactivated exhibit lipid accumulation in mesenteric lymph nodes. In mice these pathological events exclusively unfold upon feeding a high saturated fatty acid diet and are followed by an ultimately lethal pro-inflammatory response and chylous ascites...
April 15, 2017: Journal of Lipid Research
https://www.readbyqxmd.com/read/28401206/recent-advances-in-carbon-based-nanosystems-for-cancer-theranostics
#7
REVIEW
Shine Augustine, Jay Singh, Manish Srivastava, Monica Sharma, Asmita Das, Bansi D Malhotra
One of the major challenges in our contemporary society is to facilitate healthy life for all human beings. In this context, cancer has become one of the most deadly diseases around the world, and despite many advances in theranostics techniques the treatment of cancer still remains an important problem. With recent advances made in the field of nano-biotechnology, carbon-based nanostructured materials have drawn special attention because of their unique physicochemical properties, giving rise to great potential for the diagnosis and therapy of cancer...
May 2, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/28385486/analysis-and-optimization-of-process-parameters-for-production-of-polyhydroxyalkanoates-along-with-wastewater-treatment-by-serratia-sp-istvkr1
#8
Asmita Gupta, Madan Kumar, Indu Shekhar Thakur
A previously reported biodegrading bacterial strain Serratia sp. ISTVKR1 was studied for polyhydroxyalkanoate (PHA) production along with wastewater contaminant removal. Nile red fluorescence, GC-MS, FT-IR, NMR and TEM confirmed the accumulation of homopolymer poly-3-hydroxyvalerate (PHV) within the bacterial cells. Analysis of culture after 72h of bacterial treatment showed maximum COD removal (8.4-fold), non-detection of organic contaminants such as 1H-Cyclopropa [a] naphthalene (R.T.=10.12) using GC-MS and increased proportion of elements like Cr, Mn, Fe, Ni, Cu, Cd and Pb in the bacterial cell pellets by SEM-EDX analysis...
March 27, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28367029/biofilm-colonization-in-chronic-treatment-refractory-infections-presenting-with-discharging-sinuses-a-study-in-a-tertiary-care-hospital-of-eastern-india
#9
Asmita De, Hirak Jyoti Raj, Jayeeta Haldar, Poulami Mukherjee, Prasanta Kumar Maiti
INTRODUCTION: Treatment refractory chronic recurrent infections mean those chronic infections which recur by same causal agents with similar drug responsiveness after apparent relief following full course of recommended antimicrobial management. MATERIALS AND METHODS: Fifty different samples were collected from patients with chronic surgical site infections, laparoscopic port site infections, anal fistula, mesh hernioplasty, chronic dacryocystitis, chronic osteomyelitis, and chronic burn wounds...
April 2017: Journal of Laboratory Physicians
https://www.readbyqxmd.com/read/28366033/obstructed-labour-due-to-locked-twins-and-role-of-destructive-procedure-in-its-management-a-case-report
#10
Robin Medhi, Asmita Mishra, Indrani Das, Sonika Bawri
No abstract text is available yet for this article.
April 1, 2017: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28352541/incorporation-of-a-tag-helps-to-overcome-expression-variability-in-a-recombinant-host
#11
Saikat Bhattacharya, Divya Reddy, Raja Reddy, Asmita Sharda, Kakoli Bose, Sanjay Gupta
Epigenetics have witnessed a renewed interest over the past decade and assays with recombinant histones has become an important tool for uncovering various aspects of histone biology. However, at times absence of recombinant histone accumulation in bacteria is encountered which is also commonly observed for many eukaryotic proteins in general. In this study, we have investigated the effect of multiple parameters on heterologous expression of proteins. We show that there is marked variability in the accumulation of H2A...
September 2016: Biotechnology Reports
https://www.readbyqxmd.com/read/28330150/phylogenetic-relationships-of-fluorescent-pseudomonads-deduced-from-the-sequence-analysis-of-16s-rrna-pseudomonas-specific-and-rpod-genes
#12
Asmita Rajwar, Manvika Sahgal
Phylogenetic relationship of 22 FLPs was revealed on the basis of polymorphism in three genes namely 16S rDNA, Pseudomonas-specific and rpoD gene regions. The primers for 16S rDNA, Pseudomonas-specific region and rpoD gene region were amplifying a region of 1492, 990 and 760 bp, respectively, from all the isolates investigated. The RFLP analysis of the PCR products resulted in a classification of these fluorescent pseudomonads which was best answered by rpoD-based RFLP analysis. The 22 FLPs were placed in two major clusters and seven subclusters suggesting that these were genotypically heterogenous and might belong to several species within Pseudomonas sensu stricto...
June 2016: 3 Biotech
https://www.readbyqxmd.com/read/28317802/port-site-infections-by-nontuberculous-mycobacterium-a-retrospective-clinico-microbiological-study
#13
Roumi Ghosh, Soumen Das, Asmita De, Harish Kela, Makhan Lal Saha, Prasanta Kumar Maiti
BACKGROUND: Port-site infection (PSI) is a prevailing, chronic, nagging, treatment refractory complication of laparoscopic surgery (LS). It neutralizes the advantages of minimally invasive surgery and increases morbidity, treatment cost of patient, leading to loss of confidence on operating surgeon. PSIs are preventable with appropriate preoperative, intraoperative, and postoperative measures. Atypical mycobacterium is most commonly associated with nonhealing postlaparoscopic wound infections, causing outbreaks or sporadic cases worldwide...
January 2017: International Journal of Mycobacteriology
https://www.readbyqxmd.com/read/28298336/moonlighting-glycolytic-protein-glyceraldehyde-3-phosphate-dehydrogenase-gapdh-an-evolutionarily-conserved-plasminogen-receptor-on-mammalian-cells
#14
Anoop Singh Chauhan, Manoj Kumar, Surbhi Chaudhary, Anil Patidar, Asmita Dhiman, Navdeep Sheokand, Himanshu Malhotra, Chaaya Iyengar Raje, Manoj Raje
Prokaryotic pathogens establish infection in mammals by capturing the proteolytic enzyme plasminogen (Plg) onto their surface to digest host extracellular matrix (ECM). One of the bacterial surface Plg receptors is the multifunctional glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH). In a defensive response, the host mounts an inflammatory response, which involves infiltration of leukocytes to sites of inflammation. This requires macrophage exit from the blood and migration across basement membranes, a phenomenon dependent on proteolytic remodeling of the ECM utilizing Plg...
March 15, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28296393/mechanism-of-reduction-of-ferric-porphyrins-by-sulfide-identification-of-a-low-spin-fe-iii-sh-intermediate
#15
Kaustuv Mittra, Asmita Singha, Abhishek Dey
The reaction of Fe(III) porphyrin complexes bearing distal hydrogen bonding residues with sulfide/hydrosulfide is kinetically monitored to reveal the presence of an intermediate and a kH/kD of 3.0. This intermediate is trapped at low temperatures and investigated with resonance Raman and electron paramagnetic resonance spectroscopy. The results, corroborated by density functional theory calculations, indicate that this species is a six-coordinate low spin hydrosulfide bound ferric porphyrin. The homolytic cleavage of the Fe(III)-SH bond resulting in the formation of a ferrous porphyrin and hydrosulfide radical (trapped with 5,5-dimethyl-1-pyrrilone-N-oxide) is found to be the overall rate-determining step of the reaction...
April 3, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28208870/multilocular-mesothelial-cyst-of-the-spleen-mimicking-hydatid-cyst-on-imaging
#16
Asmita Parihar, Usha Rani Singh, Vineeta Rathi, Vivek Agrawal
No abstract text is available yet for this article.
December 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28167277/purification-of-recombinant-c-reactive-protein-mutants
#17
Avinash Thirumalai, Sanjay K Singh, David J Hammond, Toh B Gang, Donald N Ngwa, Asmita Pathak, Alok Agrawal
C-reactive protein (CRP) is an evolutionarily conserved protein, a component of the innate immune system, and an acute phase protein in humans. In addition to its raised level in blood in inflammatory states, CRP is also localized at sites of inflammation including atherosclerotic lesions, arthritic joints and amyloid plaque deposits. Results of in vivo experiments in animal models of inflammatory diseases indicate that CRP is an anti-pneumococcal, anti-atherosclerotic, anti-arthritic and an anti-amyloidogenic molecule...
February 3, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/28155702/molecular-modeling-and-lead-design-of-substituted-zanamivir-derivatives-as-potent-anti-influenza-drugs
#18
Dhwani Dholakia, Sukriti Goyal, Salma Jamal, Aditi Singh, Asmita Das, Abhinav Grover
BACKGROUND: Influenza virus spreads infection by two main surface glycoproteins, namely hemagglutinin (HA) and neuraminidase (NA). NA cleaves the sialic acid receptors eventually releasing newly formed virus particles which then invade new cells. Inhibition of NA could limit the replication of virus to one round which is insufficient to cause the disease. RESULTS: An experimentally reported series of acylguanidine zanamivir derivatives was used to develop GQSAR model targeting NA in different strains of influenza virus, H1N1 and H3N2...
December 22, 2016: BMC Bioinformatics
https://www.readbyqxmd.com/read/28135669/identification-of-genetic-variation-in-nod-like-receptor-2-gene-and-influence-of-polymorphism-on-gene-structure-and-function-in-buffalo-bubalus-bubalis
#19
Asmita Dhiman, S K Mishra, P K Dubey, S Goyal, M Sehgal, S K Niranjan, M Sodhi, B P Mishra, R S Kataria
Nucleotide-binding oligomerization domain (NOD)-like receptor 2 is one of the important mediators of innate as well as adaptive immune response to microbial infections. In this study, NOD-like receptor-2 was characterized by determining the full gene sequence and analyzing genetic diversity in Indian buffaloes. Sequence analysis of buffalo NOD2 revealed 3042 nucleotides long ORF, encoding 1013 amino acids from 12 exons. Domain structure analysis indicated existence of 8 leucine-rich repeat (LRR) domains in buffalo, cattle, sheep and mouse, along with central NACHT/NOD domain and two N-terminal CARD domains...
January 22, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28104702/il-2-promotes-early-treg-reconstitution-after-allogeneic-hematopoietic-cell-transplantation
#20
Brian C Betts, Joseph Pidala, Jongphil Kim, Asmita Mishra, Taiga Nishihori, Lia Perez, Jose Leonel Ochoa-Bayona, Farhad Khimani, Kelly Walton, Ryan Bookout, Michael Nieder, Divis K Khaira, Marco Davila, Melissa Alsina, Teresa Field, Ernesto Ayala, Frederick L Locke, Marcie Riches, Mohamed Kharfan-Dabaja, Hugo Fernandez, Claudio Anasetti
Graft-versus-host disease (GvHD) remains a major cause of transplant-related mortality. Interleukin-2 (IL-2) plus sirolimus (SIR) synergistically reduces acute GvHD in rodents and promotes regulatory T cells. This phase II trial tested the hypothesis that IL-2 would facilitate STAT5 phosphorylation in donor T cells, expand regulatory T cells, and ameliorate GvHD. Between 16(th) April 2014 and 19(th) December 2015, 20 patients received IL-2 (200,000 IU/m(2) thrice weekly, days 0 to +90) with SIR (5-14 ng/mL) and tacrolimus (TAC) (3-7 ng/mL) after HLA-matched related or unrelated allogeneic hematopoietic cell transplantation (HCT)...
May 2017: Haematologica
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