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https://www.readbyqxmd.com/read/29231978/impact-of-a-shift-in-nuchal-translucency-measurements-on-the-detection-rate-of-first-trimester-down-syndrome-screening-a-population-based-study
#1
Nicolas Fries, Laurent J Salomon, Françoise Muller, Sophie Dreux, Véronique Houfflin-Debarge, Philippe Coquel, Pascale Kleinfinger, Marc Dommergues
No abstract text is available yet for this article.
December 12, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29229936/identification-of-a-gene-signature-for-discriminating-metastatic-from-primary-melanoma-using-a-molecular-interaction-network-approach
#2
Rahul Metri, Abhilash Mohan, Jérémie Nsengimana, Joanna Pozniak, Carmen Molina-Paris, Julia Newton-Bishop, David Bishop, Nagasuma Chandra
Understanding the biological factors that are characteristic of metastasis in melanoma remains a key approach to improving treatment. In this study, we seek to identify a gene signature of metastatic melanoma. We configured a new network-based computational pipeline, combined with a machine learning method, to mine publicly available transcriptomic data from melanoma patient samples. Our method is unbiased and scans a genome-wide protein-protein interaction network using a novel formulation for network scoring...
December 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29225887/a-prospective-longitudinal-study-of-men-with-borderline-personality-disorder-with-and-without-comorbid-antisocial-personality-disorder
#3
Marie-Pier Robitaille, Dave Checknita, Frank Vitaro, Richard E Tremblay, Joel Paris, Sheilagh Hodgins
Background: Some evidence suggests that the prevalence of Borderline Personality Disorder (BPD) is elevated among male criminal offenders. It is not presently known whether offending, and violent offending, are limited to those presenting comorbid Antisocial Personality Disorder (ASPD) who have a childhood history of conduct problems and whether offending is linked to psychopathic traits. Methods: A community sample of 311 males followed from age 6 to 33 years, one third of whom had a criminal charge between ages 18 and 24, completed diagnostic interviews and the Psychopathy Checklist-Revised interview...
2017: Borderline Personality Disorder and Emotion Dysregulation
https://www.readbyqxmd.com/read/29223514/need-for-integrative-thinking-to-fight-against-emerging-infectious-diseases-proceedings-of-the-5th-seminar-on-emerging-infectious-diseases-march-22-2016-%C3%A2-current-trends-and-proposals
#4
C Burdet, J-F Guégan, X Duval, M Le Tyrant, H Bergeron, J-C Manuguerra, J Raude, C Leport, P Zylberman
We present here the proceedings of the 5th seminar on emerging infectious diseases, held in Paris on March 22nd, 2016, with seven priority proposals that can be outlined as follows: encourage research on the prediction, screening and early detection of new risks of infection; develop research and surveillance concerning transmission of pathogens between animals and humans, with their reinforcement in particular in intertropical areas ("hot-spots") via public support; pursue aid development and support in these areas of prevention and training for local health personnel, and foster risk awareness in the population; ensure adapted patient care in order to promote adherence to treatment and to epidemic propagation reduction measures; develop greater awareness and better education among politicians and healthcare providers, in order to ensure more adapted response to new types of crises; modify the logic of governance, drawing from all available modes of communication and incorporating new information-sharing tools; develop economic research on the fight against emerging infectious diseases, taking into account specific driving factors in order to create a balance between preventive and curative approaches...
December 6, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/29223197/an-estimation-of-a-nonlinear-dynamic-process-using-latent-class-extended-mixed-models-affect-profiles-after-terrorist-attacks
#5
Roberto Burro, Daniela Raccanello, Margherita Pasini, Margherita Brondino
Conceptualizing affect as a complex nonlinear dynamic process, we used latent class extended mixed models (LCMM) to understand whether there were unobserved groupings in a dataset including longitudinal measures. Our aim was to identify affect profiles over time in people vicariously exposed to terrorism, studying their relations with personality traits. The participants were 193 university students who completed online measures of affect during the seven days following two terrorist attacks (Paris, November 13, 2015; Brussels, March 22, 2016); Big Five personality traits; and antecedents of affect...
January 2018: Nonlinear Dynamics, Psychology, and Life Sciences
https://www.readbyqxmd.com/read/29222035/carriage-of-esbl-producing-enterobacteriaceae-in-french-hospitals-the-portablse-study
#6
B Pilmis, V Cattoir, D Lecointe, A Limelette, I Grall, A Mizrahi, G Marcade, I Poilane, T Guillard, N Bourgeois Nicolaos, J-R Zahar, A Le Monnier
BACKGROUND: Currently, contact precautions are recommended for patients colonized or infected with extended spectrum beta-lactamase producing enterobacteriaceae (ESBL-PE). Recent studies have challenged this strategy. This study aimed to assess the rate of ESBL-PE faecal carriage among hospitalized patients according to type of hospital ward, and to identify risk factors associated with carriage. METHODS: We conducted a point prevalence study in five different types of hospital wards (medical, surgical, intensive care unit (ICU), after care and rehabilitation and geriatric) in 8 French hospitals...
December 5, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29221985/hotair-mediated-reciprocal-regulation-of-ezh2-and-dnmt1-contribute-to-polyphyllin-i-inhibited-growth-of-castration-resistant-prostate-cancer-cells-in-vitro-and-in-vivo
#7
SongTao Xiang, PeiLiang Zou, Qing Tang, Fang Zheng, JingJing Wu, ZhiQiang Chen, Swei Sunny Hann
BACKGROUND: Polyphyllin I (PPI), one of the steroidal saponins in paris polyphylla, has been reported to exhibit antitumor effects. However, the detailed molecular mechanism underlying this has not been elucidated. METHODS: Cell viability and cell cycle distribution were measured using 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and Flow cytometry assays, respectively. Cell invasion and migration were examined by Transwell invasion and wound healing assays...
December 5, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/29220784/physiological-effects-caused-by-microcystin-producing-and-non-microcystin-producing-microcystis-aeruginosa-on-medaka-fish-a%C3%A2-proteomic-and-metabolomic-study-on-liver
#8
Séverine Le Manach, Benoit Sotton, Hélène Huet, Charlotte Duval, Alain Paris, Arul Marie, Claude Yépremian, Arnaud Catherine, Lucrèce Mathéron, Joelle Vinh, Marc Edery, Benjamin Marie
Cyanobacterial blooms have become a common phenomenon in eutrophic freshwater ecosystems worldwide. Microcystis is an important bloom-forming and toxin-producing genus in continental aquatic ecosystems, which poses a potential risk to Human populations as well as on aquatic organisms. Microcystis is known to produce along with various bioactive peptides, the microcystins (MCs) that have attracted more attention notably due to their high hepatotoxicity. To better understand the effects of cyanobacterial blooms on fish, medaka fish (Oryzias latipes) were sub-chronically exposed to either non-MC-producing or MC-producing living strains and, for this latter, to its subsequent MC-extract of Microcystis aeruginosa...
December 5, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29220537/milder-disease-stage-in-patients-with-primary-biliary-cholangitis-over-a-44-year-period-a-changing-natural-history
#9
Fiorella Murillo Perez, Jorn C Goet, Willem J Lammers, Aliya Gulamhusein, Henk R van Buuren, Cyriel Y Ponsioen, Marco Carbone, Andrew Mason, Christophe Corpechot, Pietro Invernizzi, Marlyn J Mayo, Pier Maria Battezzati, Annarosa Floreani, Albert Pares, Frederik Nevens, Kris V Kowdley, Tony Bruns, George N Dalekos, Douglas Thorburn, Gideon Hirschfield, Nicholas F LaRusso, Keith D Lindor, Kalliopi Zachou, Raoul Poupon, Palak J Trivedi, Xavier Verhelst, Harry L A Janssen, Bettina E Hansen
Changes over time in the presenting features and clinical course of patients with primary biliary cholangitis (PBC) are poorly described. We sought to describe temporal trends in patient and disease characteristics over a 44-year period across a large international PBC cohort of 4805 patients diagnosed between 1970 and 2014, from 17 centers across Europe and North America. Patients were divided into five cohorts according to their year of diagnosis: 1970-1979 (n=143), 1980-1989 (n=858), 1990-1999 (n=1754), 2000-2009 (n=1815), ≥2010 (n=235)...
December 8, 2017: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
https://www.readbyqxmd.com/read/29218930/-herbal-textual-research-on-origins-of-chonglou
#10
Lu Jiang, Li-Ping Kang, Da-Hui Liu, Hua-Sheng Peng, Jin Xie, Min Chen
Based on the field investigation, this paper researched the germplasms and geoherbs habitat of Chonglou in ancient herbal books systematically. The results showed that, Chonglou in ancient herbal books sometimes referred to certain specific germplasm, while sometimes it referred to many species derived from genus Paris except Sect. Paris. The medicinal material Chonglou in Chinese Materia Medica Bencaotujing and Bencaomengquan was verified as P. polyphylla var. chinensis, which could be P. polyphylla in Xinxiubencao, and it should include P...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218929/-pharmacodynamics-study-on-paris-vietnamensis
#11
Hong-Mei Li, Jian-Hui Sun, Li-Ping Kang, Hai-Ru Huo, Xiao-Qin Li, Yuan-Yuan Huang, Min Chen, Lu-Qi Huang
Paris is commonly used in traditional Chinese medicine and its resource is in shortage, a variety of related plants are acquired as Paris. This study compared pharmacological activity in anti-inflammatory and hemostatic and blood rheology of P. vietnamensis with pharmacopoeial Paridis Rhizoma to expand its range of Paris medicinal resources and protect wild resources of Paris and meet market demand. The experimental study showed that P. vietnamensis and P. polyphylla var. yunnanensis and P. polyphylla var. chinensis had anti-inflammatory and hemostatic effect and improved blood rheolog...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218928/-comparative-pharmacodynamics-study-on-paris-forrestii-and-pharmacopoeial-paridis-rhizoma
#12
Hong-Mei Li, Jian-Hui Sun, Li-Ping Kang, Hai-Ru Huo, Xiao-Qin Li, Yuan-Yuan Huang, Min Chen, Lu-Qi Huang
Paris is a raw material of a variety of Chinese medicines, which has become deficient in resource due to market demand substantial growth and wild Paris resources reducing increasingly and the artificial cultivation slow growth. This study compared pharmacological activity in analgesia and anti-inflammatory and hemostasis effects of P. forrestii with pharmacopoeial Paridis Rhizoma to expand its range of Paris medicinal resources and protect wild resources of Paris and meet market demand. The experimental study showed that P...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218927/-qualitative-and-quantitative-analyses-of-primary-saponins-in-paris-forrestii
#13
Yuan-Yuan Huang, Li-Ping Kang, Hua-Sheng Peng, Da-Hui Liu, Qing-Xiu Hao, Jia-Liu Zhao, Min Chen, Lu-Qi Huang
In order to study whether Paris forrestii could be developed as a substitute of Paridis Rhizome, chemical compositions of P. forrestii and P. polyphylla var. yunnanensis were investigated by UPLC-Q-TOF MS. In addition, the contents of eight primary steroidal saponins in 77 batches of P. forrestii samples from different habitats were simultaneously determined by HPLC-UV. The results showed that P. forrestii and P. polyphylla var. yunnanensis have similar chemical compositions, and all 22 major common peaks were identified as steroid derivatives...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29218926/-determination-of-eight-steroidal-saponins-in-15-kinds-of-genus-paris
#14
Yuan-Yuan Huang, Da-Hui Liu, Hua-Sheng Peng, Qing-Xiu Hao, Mei-Lan Chen, A-Zhong Zhang, Min Chen, Li-Ping Kang, Lu-Qi Huang
The study was established an HPLC method for simultaneous determination of 8 steroidal saponins (polyphyllins Ⅶ, H, Ⅵ, Ⅱ, Ⅰ, and Ⅴ, dioscin, and gracillin) in Paridis Rhizoma, and made an evaluation by determining steroidal saponins in 15 kinds of genus Paris. The analysis was performed on a Waters Acquity H-ClassTM UPLC ultrafine liquid chromatography system coupled with a PDA detector. The chromatographic separation was achieved through a CAPCELL PAK ADME (4.6 mm× 250 mm, 5 μm) column and the optimal mobile phase consisted of acetonitrile and water...
September 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29217826/parkinson-s-disease-the-story-of-an-eponym
#15
REVIEW
Michel Goedert, Alastair Compston
One of the most prevalent neurodegenerative diseases worldwide is still referred to as 'Parkinson's disease'. The condition is named after James Parkinson who, in 1817, described the shaking palsy (paralysis agitans). In the bicentennial year of this publication, we trace when and why the shaking palsy became Parkinson's disease. The term was coined by William Rutherford Sanders of Edinburgh in 1865 and later entered general usage through the influence of Jean-Martin Charcot and the school that he nurtured at the Salpêtrière Hospital in Paris...
December 8, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/29217446/the-use-of-the-profunda-femoral-artery-as-the-sole-target-vessel-to-bypass-aorto-iliac-disease-in-patients-with-critical-limb-ischemia-and-concomitant-unreconstructable-infra-inguinal-disease
#16
Nikolaos Kontopodis, Stella Lioudaki, Christos Chronis, Paris Kalogerakos, George Lazopoulos, Alexandra Papaioannou, Christos V Ioannou
BACKGROUND: Critical limb ischemia (CLI) often results from multilevel occlusive disease. There are occasions where a patent profunda femoral artery (PFA) is the only target artery that can be used as outflow during reconstruction to bypass aorto-iliac disease (AOID), with no further option for infra-inguinal revascularization. We aim to report results of the use of PFA as the sole target vessel for the treatment of these patients. METHODS: This is a retrospective, single-center study including CLI patients treated during 36-months...
December 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29216407/an-open-label-positron-emission-tomography-pet-study-to-evaluate-serotonin-transporter-occupancy-following-escalating-dosing-regimens-of-r-o-desmethylvenlafaxine-and-racemic-o-desmethylvenlafaxine
#17
W Gordon Frankle, Brigitte Robertson, Gary Maier, Jennifer Paris, Deanna Asmonga, Maureen May, Michael L Himes, N Scott Mason, Chester A Mathis, Rajesh Narendran
INTRODUCTION: SEP-227162 [R(-)-O-desmethylvenlafaxine] is an enantiomer of the venlafaxine metabolite O-desmethylvenlafaxine (ODV, Pristiq™, Wyeth). This study compared the serotonin transporter occupancy achieved by SEP-227162 and ODV, at daily doses of 25mg, 50mg, 100mg and 150mg using [11 C]DASB positron emission tomography (PET). METHODS: Sixteen healthy male subjects participated in one of four dose groups (N = 4 per group) during which they were administered two doses of the study drug (SEP-227162 or ODV)...
December 7, 2017: Synapse
https://www.readbyqxmd.com/read/29214289/treated-incidence-of-psychotic-disorders-in-the-multinational-eu-gei-study
#18
Hannah E Jongsma, Charlotte Gayer-Anderson, Antonio Lasalvia, Diego Quattrone, Alice Mulè, Andrei Szöke, Jean-Paul Selten, Caitlin Turner, Celso Arango, Ilaria Tarricone, Domenico Berardi, Andrea Tortelli, Pierre-Michel Llorca, Lieuwe de Haan, Julio Bobes, Miguel Bernardo, Julio Sanjuán, José Luis Santos, Manuel Arrojo, Cristina Marta Del-Ben, Paulo Rossi Menezes, Robin M Murray, Bart P Rutten, Peter B Jones, Jim van Os, Craig Morgan, James B Kirkbride
Importance: Psychotic disorders contribute significantly to the global disease burden, yet the latest international incidence study of psychotic disorders was conducted in the 1980s. Objectives: To estimate the incidence of psychotic disorders using comparable methods across 17 catchment areas in 6 countries and to examine the variance between catchment areas by putative environmental risk factors. Design, Setting, and Participants: An international multisite incidence study (the European Network of National Schizophrenia Networks Studying Gene-Environment Interactions) was conducted from May 1, 2010, to April 1, 2015, among 2774 individuals from England (2 catchment areas), France (3 catchment areas), Italy (3 catchment areas), the Netherlands (2 catchment areas), Spain (6 catchment areas), and Brazil (1 catchment area) with a first episode of nonorganic psychotic disorders (International Statistical Classification of Diseases and Related Health Problems, Tenth Revision [ICD-10] codes F20-F33) confirmed by the Operational Criteria Checklist...
December 6, 2017: JAMA Psychiatry
https://www.readbyqxmd.com/read/29212777/detection-and-monitoring-of-circulating-tumor-dna-in-adrenocortical-carcinoma
#19
Simon Garinet, Juliette Nectoux, Mario Neou, Eric Pasmant, Anne Jouinot, Mathilde Sibony, Lucie Orhant, Juliana Pipoli da Fonseca, Karine Hecale-Perlemoine, Leopoldine Bricaire, Lionel Groussin, Olivier Soubrane, Bertrand Dousset, Rossella Libé, Franck Letourneur, Jerome Bertherat, Guillaume Assié
Adrenocortical carcinomas (ACC) are aggressive tumors with limited prognostic and follow-up biomarkers. Circulating tumor DNA (ctDNA) is an emerging biomarker, now used for several cancer types. This study aimed to reliably detect and quantify ctDNA in ACC patients; to identify parameters impacting detection of ctDNA. A prospective monocentric study conducted in Cochin Hospital and Cochin Institute, Paris, France. Eleven ACC patients were included with either primary tumor or relapse or metastases from 2015 to 2016...
December 6, 2017: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29212665/association-between-individual-and-neighbourhood-socioeconomic-factors-and-masticatory-efficiency-a-cross-sectional-analysis-of-the-paris-prospective-study-3
#20
Adrien Boillot, Xavier Jouven, Hélène Rangé, Marie Cécile Perier, Frédérique Thomas, Catherine Guibout, Bruno Pannier, Pierre Boutouyrie, Jean-Philippe Empana, Philippe Bouchard
BACKGROUND: There is a lack of evidence on the impact of socioeconomic factors on masticatory efficiency. The present study investigates the relationship between individual and neighbourhood socioeconomic factors (main exposure) and the number of masticatory units (MUs) used as surrogate of the masticatory efficiency (main outcome). METHODS: In this cross-sectional study nested in the Paris Prospective Study 3, 4270 adults aged 50-75 and recruited from 13 June 2008 to 31 May 2012 underwent a full-mouth examination...
December 6, 2017: Journal of Epidemiology and Community Health
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