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Julie Rotival, Youri Yordanov, Pierre-Clément Thiebaud, Nathalie Pelletier-Fleury, Elsa Jacquet, Erwan Debuc, Dominique Pateron, Diane Naouri
Background: Some studies have demonstrated an association between poor continuity of care, high likelihood of 'inappropriate' use of emergency departments (EDs) and avoidable hospitalization. However, we lack data concerning primary care use after an ED visit. Objective: Identify the determinants of a visit to the general practitioner (GP) after an ED visit. Design: Observational study (single-centre cohort). Setting: One emergency department in Paris, France...
June 21, 2018: Family Practice
Renata De Paris, Christian Vahl Quevedo, Duncan D Ruiz, Furia Gargano, Osmar Norberto de Souza
BACKGROUND: In the rational drug design process, an ensemble of conformations obtained from a molecular dynamics simulation plays a crucial role in docking experiments. Some studies have found that Fully-Flexible Receptor (FFR) models predict realistic binding energy accurately and improve scoring to enhance selectiveness. At the same time, methods have been proposed to reduce the high computational costs involved in considering the explicit flexibility of proteins in receptor-ligand docking...
June 22, 2018: BMC Bioinformatics
Patrick J McIntire, Justin T Snow, Brian D Robinson, Rema A Rao, Abha Goyal, Jonas J Heymann, Momin T Siddiqui
BACKGROUND: Urine cytology specimens are essential for screening and monitoring high-grade urothelial carcinomas. However, inconsistent reporting and equivocal diagnostic categories have remained a challenge. The Paris System for Reporting Urinary Cytology (TPS) was developed to provide clear cytomorphologic criteria for urine cytology specimens. Significant correlation between the surgical biopsy diagnosis (SD) and TPS diagnosis (PD) has been established in lower urothelial tract carcinomas, but to the authors' knowledge limited information is available regarding upper urinary tract carcinomas...
June 21, 2018: Cancer Cytopathology
Ronak Sandy, Quentin Hennocq, Johan Nysjö, Guillaume Giran, Martin Friess, Roman Hossein Khonsari
Intentional cranial deformations are the result of external mechanical forces exerted on the skull vault that modify the morphology of various craniofacial structures such as the skull base, the orbits and the zygoma. In this controlled study, we investigated the 3D shape of the orbital inner mould and the orbital volume in various types of intentional deformations and in adult non-operated scaphocephaly - the most common type of craniosynostosis - using dedicated morphometric methods. CT scans were performed on 32 adult skulls with intentional deformations, 21 adult skull with scaphocephaly and 17 non-deformed adult skulls from the collections of the Muséum national d'Histoire naturelle in Paris, France...
June 21, 2018: Journal of Anatomy
Kazuhisa Iwabuchi
Although individuals are constantly exposed to infectious agents, these agents are generally resisted by the innate and acquired immune systems. Both the innate and acquired immune systems protect against invading organisms, but they differ functionally in several ways. The innate immune system is the body's inborn defense mechanism and the first line of defense against invading organisms, such as bacteria, fungi, and viruses. Glycosphingolipids (GSLs), which are expressed on the outer leaflet of plasma membranes (Murate et al...
2018: Methods in Molecular Biology
Rachel Wodarski, Deniz Bagdas, Jason J Paris, Tim Pheby, Wisam Toma, Ruqiang Xu, M Imad Damaj, Pamela E Knapp, Andrew S C Rice, Kurt F Hauser
Introduction: HIV infection is associated with chronic pain states, including sensory neuropathy, which affects greater than 40% of patients. Objectives and Methods: To determine the impact of HIV-Tat induction on nociceptive behaviour in female mice conditionally expressing HIV Tat1-86 protein through a doxycycline (DOX)-driven glial fibrillary acidic protein promoter, intraepidermal nerve fibre density and immune cell activation in the dorsal root ganglion (DRG) and spinal cord were assessed by immunohistochemistry...
May 2018: Pain Reports (Baltimore, Md.)
Manish Rohilla, Priya Singh, Arvind Rajwanshi, Nalini Gupta, Radhika Srinivasan, Pranab Dey, Nandita Kakkar
OBJECTIVES: Urine cytology has a high sensitivity in morphological recognition of high grade urothelial carcinoma (HGUC) as compared to low grade urothelial neoplasms. The Paris system (TPS) was designed to standardise the reporting of HGUC on urine cytology. We evaluated the diagnostic efficacy of urine cytology in routine practice with the cytohistological correlation and application of TPS. METHODS: A retrospective review of urine cytology reported from the year 2014 to 2015 was carried out with cytohistological correlation, wherever available...
June 19, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
Jean-Baptiste Cazauran, Lucas Pâris, Pascal Rousset, Frédéric Mercier, Vahan Kepenekian, Anthony Viste, Guillaume Passot
BACKGROUND: Surgery remains the gold standard both for delimited hepatocellular carcinoma by selective anatomic liver segentectomy and for colorectal liver metastases by parenchymal sparing liver resection. Right anterior sector (RAS) (segments V-VIII; Couinaud) is the largest and most difficult sector to operate on. A better knowledge of its segmentation could prevent postoperative remnant liver ischemia and its impacts on patient's survival. METHODS: A literature search was conducted in PubMed for papers on anatomy and surgery of the right anterior sector...
June 18, 2018: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
Shai Rosenberg, Iva Simeonova, Franck Bielle, Maite Verreault, Bertille Bance, Isabelle Le Roux, Mailys Daniau, Arun Nadaradjane, Vincent Gleize, Sophie Paris, Yannick Marie, Marine Giry, Marc Polivka, Dominique Figarella-Branger, Marie-Hélène Aubriot-Lorton, Chiara Villa, Alexandre Vasiljevic, Emmanuèle Lechapt-Zalcman, Michel Kalamarides, Ariane Sharif, Karima Mokhtari, Stefano Maria Pagnotta, Antonio Iavarone, Anna Lasorella, Emmanuelle Huillard, Marc Sanson
Chordoid glioma (ChG) is a characteristic, slow growing, and well-circumscribed diencephalic tumor, whose mutational landscape is unknown. Here we report the analysis of 16 ChG by whole-exome and RNA-sequencing. We found that 15 ChG harbor the same PRKCA D463H mutation. PRKCA encodes the Protein kinase C (PKC) isozyme alpha (PKCα) and is mutated in a wide range of human cancers. However the hot spot PRKCA D463H mutation was not described in other tumors. PRKCA D463H is strongly associated with the activation of protein translation initiation (EIF2) pathway...
June 18, 2018: Nature Communications
Raphaël Le Bouc, Frédéric Clarençon, Elena Meseguer, Bertrand Lapergue, Arturo Consoli, Guillaume Turc, Olivier Naggara, Duc Long Duong, Jerome Servan, Peggy Reiner, Marc Antoine Labeyrie, Mathieu Fisselier, Raphaël Blanc, Wassim Farhat, Christine Pires, Mathieu Zuber, Michael Obadia, Mikael Mazighi, Fernando Pico, Jean-Louis Mas, Pierre Amarenco, Yves Samson
BACKGROUND AND PURPOSE: Efficacy of endovascular treatment (EVT) for ischemic stroke because of large vessel occlusion may depend on patients' age and stroke severity; we, therefore, developed a prognosis score based on these variables and examined whether EVT efficacy differs between patients with good, intermediate, or poor prognostic score. METHODS: A total of 4079 patients with an acute ischemic stroke were identified from the Paris Stroke Consortium registry...
June 18, 2018: Stroke; a Journal of Cerebral Circulation
Gro Killi Haugstad, Unni Kirste, Siv Leganger, Elin Haakonsen, Tor S Haugstad
Historic background and development of our somatocognitive approach Mensendieck physiotherapy of the Oslo School is a tradition of physiotherapy founded by the American physician Bess Mensendieck, a contemporary and fellow student of Sigmund Freud at the Paris School of Neurology. It builds on the principles of functional anatomy and the theories of motor learning. We have further developed the theory and practice from this physiotherapy tradition, challenged by the enormous load of patients with longstanding, incapacitating pain on western health care systems, by seeking to incorporate inspirational ideas from body oriented dynamic psychotherapy and cognitive psychotherapy...
December 29, 2017: Scandinavian Journal of Pain
Antonia V Seligowski, Erin Bondy, Paris Singleton, Holly K Orcutt, Kerry J Ressler, Randy P Auerbach
Fear-potentiated startle (FPS) paradigms provide insight into fear learning mechanisms that contribute to impairment among individuals with posttraumatic stress symptoms (PTSS). Electrophysiology also has provided insight into these mechanisms through the examination of event-related potentials (ERPs) such as the P100 and LPP. It remains unclear, however, whether the P100 and LPP may be related to fear learning processes within the FPS paradigm. To this end, we tested differences in ERP amplitudes for conditioned stimuli associated (CS+) and not associated (CS-) with an aversive unconditioned stimulus (US) during fear acquisition...
June 11, 2018: Psychiatry Research
David Duroy, Olivier Sabbagh, Ariane Baudel, Michel Lejoyeux
Compulsive buying is associated with significant psychiatric comorbidity, such as personality disorders. Few studies have focused on the dimensional model of personality disorders in compulsive buying. We aimed to assess the eventual presence of personality dysfunctions in compulsive buying according to the Diagnostic and Statistical Manual of Mental Disorder, 5th edition (DSM-5) dimensional conception of personality disorders. We screened online compulsive buying (QABB), characterized purchasing behavior and explored DSM-5 personality trait domains (Personality Inventory for DSM-5-Brief Form [PID-5-BF]) in 233 Paris psychology students using an online self-reporting questionnaire...
June 8, 2018: Psychiatry Research
Emmanuel Roze, Yulia Worbe, Céline Louapre, Aurélie Méneret, Cécile Delorme, Eavan McGovern, Marta Ruiz, Jean Capron, Raphaël Le Bouc, Stéphane Epelbaum, Sonia Alamowitch, Alexandre Duguet, Marie-Christine Renaud, Olivier Palombi, Tamara M Pringsheim, Constance Flamand-Roze, Olivier Steichen
Basic examination and diagnostic skills in neurology are important for every graduating medical student. However, a majority of medical students consider neurology as complex and difficult to master. We evaluate the impact a learner-friendly, innovative simulation-based training programme has on long-term retention and delayed recall of neurological semiology amongst third-year medical students from the University Pierre et Marie Curie in Paris, France. The 2013 class received standard teaching in neurological semiology...
June 7, 2018: Journal of the Neurological Sciences
Bruno Halioua
Seventy-five years ago, the Vel' d'Hiv Roundup (commonly called in French the "Rafle du Vel' d'Hiv"), was a Nazi decreed raid and mass arrest of Jewish in Paris by the French police on 16 and 17 July 1942. During the action, 13,152 Jews including 4115 children were captured and placed in hellish conditions in the Paris Velodrome to be delivered to the Nazi killing machine. A team of doctors and nurses of the Red Cross, assisted by Jewish doctors, ensured the medical care of the internees of the Vél'd'Hiv with unusual dedication...
June 13, 2018: La Presse Médicale
Roy La Touche, Mónica Grande-Alonso, Ferran Cuenca-Martínez, Luis Gónzalez-Ferrero, Luis Suso-Martí, Alba Paris-Alemany
BACKGROUND: Low back pain (LBP) is the most prevalent musculoskeletal problem among adults. It has been observed that patients with chronic pain have maladaptive neuroplastic changes and difficulty in imagination processes. OBJECTIVE: To assess the ability of patients with chronic LBP (CLBP) to generate kinesthetic and visual motor images and the time they spent on this mental task compared with asymptomatic participants. DESIGN: Prospective, A cross-sectional study...
June 14, 2018: PM & R: the Journal of Injury, Function, and Rehabilitation
T Xu, A S M Alharthi, F Batistel, A Helmbrecht, C Parys, E Trevisi, X Shen, J J Loor
The study investigated whether methionine supply during late pregnancy is associated with liver mammalian target of rapamycin (MTOR) pathway phosphorylation, plasma biomarkers, and growth in heifer calves born to cows fed a control diet (CON) or the control diet plus ethylcellulose rumen-protected methionine (MET; 0.09% of dry matter intake) for the last 28 d prepartum. Calves were fed and managed similarly during the first 56 d of age. Plasma was harvested at birth and 2, 7, 21, 42, and 50 d of age and was used for biomarker profiling...
June 13, 2018: Journal of Dairy Science
L Han, F Batistel, Y Ma, A S M Alharthi, C Parys, J J Loor
The periparturient period is the most critical period during the lactation cycle of dairy cows and is characterized by increased oxidative stress status. The objective of this experiment was to evaluate the effect of supplementing rumen-protected methionine on nuclear factor erythroid 2-like 2 (NFE2L2, formerly NRF2) protein and target gene expression in the mammary gland during the early postpartal period. Multiparous Holstein cows were used in a block design experiment with 30 cows per treatment. Treatments consisting of a basal control diet (control) or the basal diet plus rumen-protected methionine (methionine) were fed from d -28 to 60 relative to parturition...
June 13, 2018: Journal of Dairy Science
Martijn Kerkhofs, Bruno Seitaj, Hristina Ivanova, Giovanni Monaco, Geert Bultynck, Jan B Parys
Ca2+ signaling governs a diverse range of cellular processes and, as such, is subject to tight regulation. A main component of the complex intracellular Ca2+ -signaling network is the inositol 1,4,5-trisphosphate (IP3 ) receptor (IP3 R), a tetrameric channel that mediates Ca2+ release from the endoplasmic reticulum (ER) in response to IP3 . IP3 R function is controlled by a myriad of factors, such as Ca2+ , ATP, kinases and phosphatases and a plethora of accessory and regulatory proteins. Further complexity in IP3 R-mediated Ca2+ signaling is the result of the existence of three main isoforms (IP3 R1, IP3 R2 and IP3 R3) that display distinct functional characteristics and properties...
June 12, 2018: Biochimica et Biophysica Acta
Francesca Schiano di Cola, Elisa Pari, Salvatore Caratozzolo, Chiara Mancinelli, Paolo Liberini, Renata Rao, Alessandro Padovani
No abstract text is available yet for this article.
June 2018: Neurological Sciences
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