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https://www.readbyqxmd.com/read/28453911/validation-of-biomechanical-deformable-image-registration-in-the-abdomen-thorax-and-pelvis-in-a-commercial-radiotherapy-treatment-planning-system
#1
Michael Velec, Joanne L Moseley, Stina Svensson, Björn Hårdemark, David A Jaffray, Kristy K Brock
PURPOSE: The accuracy of deformable image registration tools can vary widely between imaging modalities and specific implementations of the same algorithms. A biomechanical model-based algorithm initially developed in-house at an academic institution was translated into a commercial radiotherapy treatment planning system and validated for multiple imaging modalities and anatomic sites. METHODS: Biomechanical deformable registration (Morfeus) is a geometry driven algorithm based on the finite element method...
April 28, 2017: Medical Physics
https://www.readbyqxmd.com/read/28453347/drill-penetration-injury-to-extensor-tendons-a-biomechanical-analysis
#2
Jared M Mahylis, Anora K Burwell, Laura Bonneau, Lynn M Marshall, Adam J Mirarchi
BACKGROUND: Little is known about extensor tendon failure following drill injury at the time of volar plate fixation. Our goals were to analyze extensor tendon injury following simulated drill penetration, and change in tendon displacement during cyclic loading following simulated drill penetration injury. METHODS: Extensor pollicis longus (EPL) and extensor carpi radialis brevis (ECRB) tendons were harvested from 9 fresh frozen cadaveric arms. Eighteen EPL and 18 ECRB samples were created from harvested tendons...
May 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28449528/the-link-between-tuberculosis-and-body-mass-index
#3
EDITORIAL
Aaron R Casha, Marco Scarci
The evidence behind the strong correlation between reactivation of tuberculosis (TB) and low body mass index (BMI) was reviewed. This strong association between TB and BMI occurred only with pulmonary TB and not extra-pulmonary TB, indicating that a low-BMI body build may in some way predispose to TB reactivation in the lungs. A possible explanation may be the congenital apical lung bullae that occur in 15% of the population and are likely to enlarge in young low-BMI males since biomechanical modeling of pleural stress has shown a massive 40x increase in apical pleural stress in low antero-posterior (AP) diameter chests associated with a low-BMI build...
March 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/28448908/biological-impacts-of-glyphosate-on-morphology-embryo-biomechanics-and-larval-behavior-in-zebrafish-danio-rerio
#4
Shuhui Zhang, Jia Xu, Xiangyu Kuang, Shibao Li, Xiang Li, Dongyan Chen, Xin Zhao, Xizeng Feng
All of these days, residues of herbicides such as glyphosate are widely distributed in the environment. The ubiquitous use of glyphosate has drawn extensive attention to its toxicity as an organic pollutant. In this study, we employed larval zebrafish as an animal model to evaluate the effect of different concentrations of glyphosate on early development via morphological, biomechanics, behavioral and physiological analyses. Morphological results showed that an obvious delay occurred in the epiboly process and body length, eye and head area were reduced at concentrations higher than 10 mg/L...
April 21, 2017: Chemosphere
https://www.readbyqxmd.com/read/28448167/standardized-error-severity-score-ess-ratings-to-quantify-risk-associated-with-child-restraint-system-crs-and-booster-seat-misuse
#5
Christina M Rudin-Brown, Chelsea Kramer, Robin Langerak, Andrea Scipione, Shelley Kelsey
OBJECTIVE: Although numerous research studies have reported high levels of error and misuse of child restraint systems (CRS) and booster seats in experimental and real world scenarios, conclusions are limited because they provide little information regarding which installation issues pose the highest risk and thus should be targeted for change. Beneficial to legislating bodies and researchers alike would be a standardized, globally relevant, assessment of the potential injury risk associated with more common forms of CRS and booster seat misuse, which could be applied with observed error frequency, for example, in car seat clinics or during prototype user testing, to better identify and characterize the installation issues of greatest risk to safety...
April 27, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/28447742/bone-morphogenetic-protein-9-stimulates-callus-formation-in-osteoporotic-rats-during-fracture-healing
#6
Xing Wang, Jun Huang, Fan Huang, Jian-Chun Zong, Xi Tang, Yang Liu, Qiong-Fang Zhang, Yang Wang, Liang Chen, Liang-Jun Yin, Bai-Cheng He, Zhong-Liang Deng
Fracture healing involves the coordinated actions of multiple cytokines. Bone morphogenetic protein 9 (BMP9) is an important factor in bone formation. The present study aimed to investigate the osteogenic potential of bone marrow stem cells (BMSCs) in response to adenoviral (Ad)BMP9, and the early fracture repair properties of AdBMP9 in surgically‑created fractures in osteoporotic rats. Alkaline phosphatase (ALP) activity was assayed and matrix mineralization was examined by Alizarin Red S staining. mRNA and protein expression levels of BMP9, runt‑related transcription factor 2 (RUNX2) and type 1 collagen (COL‑1) were detected in vitro and in vivo...
March 9, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28447404/potential-biomechanical-roles-of-risk-factors-in-the-evolution-of-thrombus-laden-abdominal-aortic-aneurysms
#7
Lana Virag, John S Wilson, Jay D Humphrey, Igor Karšaj
Abdominal aortic aneurysms (AAAs) typically harbour an intraluminal thrombus (ILT), yet most prior computational models neglect biochemomechanical effects of thrombus on lesion evolution. We recently proposed a growth and remodelling model of thrombus-laden AAAs that introduced a number of new constitutive relations and associated model parameters. Because values of several of these parameters have yet to be elucidated by clinical data, and could vary significantly from patient to patient, the aim of this study was to investigate the possible extent to which these parameters influence AAA evolution...
April 26, 2017: International Journal for Numerical Methods in Biomedical Engineering
https://www.readbyqxmd.com/read/28447127/bone-adaptation-of-a-biologically-reconstructed-femur-after-ewing-sarcoma-long-term-morphological-and-densitometric-evolution
#8
Giordano Valente, Fulvia Taddei, Andrea Roncari, Enrico Schileo, Marco Manfrini
Combining bone allografts and vascularized fibular autografts in intercalary reconstructions after resection of bone sarcomas is of particular interest in young patients as it facilitates bone healing and union and helps reduce fractures. However, adverse events related to bone adaptation still occur. Bone adaptation is driven by mechanical loading, but no quantitative biomechanical studies exist that would help surgical planning and rehabilitation. We analyzed the bone adaptation of a successful femoral reconstruction after Ewing sarcoma during 76-month follow-up using a novel methodology that allows CT-based quantification of morphology and density...
April 26, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28446767/two-photon-autofluorescence-lifetime-imaging-of-human-skin-papillary-dermis-in-vivo-assessment-of-blood-capillaries-and-structural-proteins-localization
#9
Evgeny A Shirshin, Yury I Gurfinkel, Alexander V Priezzhev, Victor V Fadeev, Juergen Lademann, Maxim E Darvin
The papillary dermis of human skin is responsible for its biomechanical properties and for supply of epidermis with chemicals. Dermis is mainly composed of structural protein molecules, including collagen and elastin, and contains blood capillaries. Connective tissue diseases, as well as cardiovascular complications have manifestations on the molecular level in the papillary dermis (e.g. alteration of collagen I and III content) and in the capillary structure. In this paper we assessed the molecular structure of internal and external regions of skin capillaries using two-photon fluorescence lifetime imaging (FLIM) of endogenous compounds...
April 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28446697/hydrodynamic-regime-determines-the-feeding-success-of-larval-fish-through-the-modulation-of-strike-kinematics
#10
Victor China, Liraz Levy, Alex Liberzon, Tal Elmaliach, Roi Holzman
Larval fishes experience extreme mortality rates, with 99% of a cohort perishing within days after starting to actively feed. While recent evidence suggests that hydrodynamic factors contribute to constraining larval feeding during early ontogeny, feeding is a complex process that involves numerous interacting behavioural and biomechanical components. How these components change throughout ontogeny and how they contribute to feeding remain unclear. Using 339 observations of larval feeding attempts, we quantified the effects of morphological and behavioural traits on feeding success of Sparus aurata larvae during early ontogeny...
April 26, 2017: Proceedings. Biological Sciences
https://www.readbyqxmd.com/read/28446539/transient-mechanical-strain-promotes-the-maturation-of-invadopodia-and-enhances-cancer-cell-invasion-in-vitro
#11
Alexander N Gasparski, Snehal Ozarkar, Karen A Beningo
Cancer cell invasion is influenced by various biomechanical forces found within the microenvironment. We have previously found that invasion is enhanced in fibrosarcoma cells when transient mechanical stimulation is applied within an in vitro mechano-invasion assay. This enhancement of invasion is dependent on cofilin, a known regulator of invadopodia maturation. Invadopodia are actin-rich structures present in invasive cancer cells that are enzymatically active and degrade the surrounding extracellular matrix to facilitate invasion...
April 26, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28446371/beware-of-the-toilet-the-risk-for-a-deep-tissue-injury-during-toilet-sitting
#12
Maayan Lustig, Ayelet Levy, Kara Kopplin, Zehava Ovadia-Blechman, Amit Gefen
A pressure injury (PrI) compromises quality of life and can be life-threatening. The fundamental cause of PrIs is sustained deformations in weight-bearing soft tissues, e.g., during prolonged sitting on inadequate surfaces such as a toilet seat. In nursing homes and geriatric facilities, patients need assistance using the restroom, and patients being left on the toilet for tens-of-minutes is a real-world scenario, unfortunately. Nevertheless, there are no published studies regarding sustained tissue loads during toilet sitting and their effects on tissue physiology...
April 23, 2017: Journal of Tissue Viability
https://www.readbyqxmd.com/read/28446072/the-influence-of-force-direction-on-the-fracture-pattern-and-fracture-resistance-of-canine-teeth-in-dogs
#13
Stephanie Goldschmidt, Catherine Zimmerman, Caitlyn Collins, Scott Hetzel, Heidi-Lynn Ploeg, Jason W Soukup
Biomechanical studies of the elongated canine tooth of animals are few, and thus our understanding of mechanical and physical properties of animal teeth is limited. The objective of the present study was to evaluate the influence of force direction on fracture resistance and fracture pattern of canine teeth in an ex vivo dog cadaver model. Forty-five extracted canine teeth from laboratory beagle dogs were standardized by hard tissue volume and randomly distributed among 3 force direction groups. The teeth were secured within a universal testing machine and a load was applied at different directions based on testing group...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28445855/speed-dependent-effects-of-laterally-wedged-insoles-on-gait-biomechanics-in-healthy-subjects
#14
Felix Kluge, Sebastian Krinner, Matthias Lochmann, Bjoern M Eskofier
Laterally wedged insoles have been shown to be effective for the reduction of the knee adduction moment and other biomechanical variables that are associated with the pathogenesis of knee osteoarthritis. However, inconclusive results such as adverse effects in individual subjects or even no group-wise wedge effects have been presented in different studies and it has been suggested to identify variables that potentially confound the wedge effect. The main objective of this study was the investigation of interaction effects of lateral wedges with walking speed, as different self-selected speeds have mainly been used in previous studies...
April 9, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28445366/biomechanical-integrity-in-craniofacial-surgery-calvarial-reconstruction-in-favorable-and-infected-defects-with-bone-morphogenetic-protein-2
#15
Zoe M MacIsaac, Sarah E Henderson, Sameer Shakir, Sanjay Naran, Darren M Smith, Liliana Camison, James J Cray, Alejandro J Almarza, Gregory M Cooper, Joseph E Losee
BACKGROUND: The limitations of autologous and alloplastic reconstruction for craniofacial bone defects have created a clinical need for viable tissue-engineering strategies. Recombinant human bone morphogenetic protein-2 (rhBMP-2) has shown promise in this setting. The aim of this study was to determine the long-term biomechanical properties of rhBMP-2-mediated calvarial reconstruction. METHODS: Twelve-week-old New Zealand White rabbits underwent subtotal calvarectomy...
May 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28444585/corr-insights-%C3%A2-prediction-of-polyethylene-wear-rates-from-gait-biomechanics-and-implant-positioning-in-total-hip-replacement
#16
Stephen Li
No abstract text is available yet for this article.
April 25, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28444523/iop-measurement-in-silicone-oil-tamponade-eyes-by-corvis-st-tonometer-goldmann-applanation-tonometry-and-non-contact-tonometry
#17
Yang Zhang, Lin Zheng, Ailing Bian, Qi Zhou
PURPOSE: To compare the postoperative intraocular pressure (IOP) of eyes following pars plana vitrectomy (PPV) combined with intravitreal silicone oil (SO) tamponade by Corneal Visualization Scheimpflug Technology (CST), Goldmann applanation tonometry (GAT) and non-contact tonometry (NCT). METHODS: Thirty-eight participants who had undergone PPV combined with SO tamponade to treat vitreoretinal diseases were enrolled. Postoperative IOP measurements were obtained using CST, NCT and GAT...
April 25, 2017: International Ophthalmology
https://www.readbyqxmd.com/read/28444478/the-association-between-geometry-and-wall-stress-in-emergently-repaired-abdominal-aortic-aneurysms
#18
Sathyajeeth S Chauhan, Carlos A Gutierrez, Mirunalini Thirugnanasambandam, Victor De Oliveira, Satish C Muluk, Mark K Eskandari, Ender A Finol
Abdominal aortic aneurysm (AAA) is a prevalent cardiovascular disease characterized by the focal dilation of the aorta, which supplies blood to all the organs and tissues in the systemic circulation. With the AAA increasing in diameter over time, the risk of aneurysm rupture is generally associated with the size of the aneurysm. If diagnosed on time, intervention is recommended to prevent AAA rupture. The criterion to decide on surgical intervention is determined by measuring the maximum diameter of the aneurysm relative to the critical value of 5...
April 25, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28444241/cervical-spine-muscle-tendon-unit-length-differences-between-neutral-and-forward-head-postures-biomechanical-study-using-human-cadaveric-specimens
#19
Saeed Khayatzadeh, Olivia A Kalmanson, Dale Schuit, Robert M Havey, Leonard I Voronov, Alexander J Ghanayem, Avinash G Patwardhan
Background: Forward Head Posture (FHP) may be associated with neck pain and poor health-related quality of life. Literature describes only qualitative muscle length changes associated with FHP. Objective: To quantify how muscle-tendon unit lengths are altered when human cadaveric specimens are placed in alignments representing different severities of FHP. Design: Biomechanical study using 13 fresh-frozen cadaveric cervical spine specimens (Occiput-T1, 54±15yrs)...
April 21, 2017: Physical Therapy
https://www.readbyqxmd.com/read/28443571/numerical-optimization-of-the-position-in-femoral-head-of-proximal-locking-screws-of-proximal-femoral-nail-system-biomechanical-study
#20
Mehmet Nuri Konya, Özgür Verim
BACKGROUND: Proximal femoral fracture rates are increasing due to osteoporosis and traffic accident. Proximal femoral nails are routinely used in the treatment of these fractures on the proximal femur. AIMS: The present study aimed to compare various combination and to determine ideal proximal lag screw (PLS) position on the pertrochanteric fractures (AO classification 31-A1) of femur by using optimised finite element analysis. STUDY DESIGN: Biomechanical Study...
April 6, 2017: Balkan Medical Journal
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