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https://www.readbyqxmd.com/read/28222564/neurological-and-functional-recovery-in%C3%A2-tuberculosis-patients-with-spinal-cord%C3%A2-injury-in-the-netherlands
#1
Eva M N Wouda, Ymkje Stienstra, Tjip S van der Werf, Huib Kerstjens, Wiel C M de Lange, Maarten Coppes, Jos Kuijlen, Marga Tepper, Onno W Akkerman
BACKGROUND: Spinal tuberculosis (TB) accounts for approximately 1% to 3% of all TB cases and it can cause a wide range of neurological symptoms, from none to a complete spinal cord injury (SCI), resulting in complete paraplegia or tetraplegia. OBJECTIVES: To describe the functional and neurological outcome of SCI caused by TB. METHODS: Retrospective data on the admission period was combined with prospectively collected data on long-term follow-up...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222563/afferent-electrical-stimulation-during-cycling-improves-spinal-processing-of-sensorimotor-function-after-incomplete-spinal-cord-injury
#2
Stefano Piazza, Diego Serrano-Muñoz, Julio Gómez-Soriano, Diego Torricelli, Antonio Segura-Fragosa, José Luis Pons, Julian Taylor
OBJECTIVE: Appropriate afferent feedback delivery during the execution of motor tasks is important for rehabilitation after incomplete spinal cord injury (iSCI). However, during leg-cycling therapy, the plantar afferent feedback is minimal. We hypothesize that the augmentation of sensory input by combining cycling with a locomotor-like stimulation of plantar cutaneous innervations (ES-cycling), might help to restore proper spinal processing of sensorimotor function. METHODS: 13 non-injured subjects and 10 subjects with iSCI performed 10 minutes of cycling and, on another session, of ES-cycling...
February 10, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222553/dual-afferent-sensory-input-training-for-voluntary-movement-after-stroke-a-pilot-randomized-controlled-study
#3
Seahyun Bae, Kyung-Yoon Kim
BACKGROUND: Stimulation through afferent sensory input is necessary to improve voluntary functional movement in stroke patients. OBJECTIVES: Dual-afferent sensory input, which combines electromyography-triggered functional electric stimulation (ETFES) and action observation, was investigated to determine its effects on voluntary movements in stroke patients. METHODS: This study was conducted on 18 patients with left hemiplegia diagnosed between 6 and 24 months prior...
February 8, 2017: NeuroRehabilitation
https://www.readbyqxmd.com/read/28222441/unusual-occurrence-of-multifocal-desmoplastic-infantile-astrocytoma-a-case-report-and-review-of-the-literature
#4
Vinayak Narayan, Amey R Savardekar, Anita Mahadevan, Arimappamagan Arivazhagan, Lingegowda Appaji
Desmoplastic infantile gliomas are rare, benign tumors of the early infancy period. Two histological subtypes - desmoplastic infantile astrocytoma (DIA) and desmoplastic infantile ganglioglioma - have been described. The characteristic features of DIAs are lobar location, glial histology, and excellent prognosis after complete surgical excision. DIAs usually present as solitary, cortical-surfacing, solid-cystic neoplasms; however, atypical, aggressive, and multifocal variants of DIA have been reported in the literature...
February 22, 2017: Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28222402/impact-of-anchor-type-on-porcine-lumbar-biomechanics-finite-element-modelling-and-in-vitro-validation
#5
Martin Brummund, Vladimir Brailovski, Yvan Petit, Yann Facchinello, Jean-Marc Mac-Thiong
BACKGROUND: Rigid posterior implants used for spinal stabilization can be anchored to the vertebrae using pedicle screws or screws combined with transverse process hooks. In the present study, a finite element model of a porcine lumbar spine instrumented with screws and hooks is presented and validated. METHODS: The porcine lumbar spine model was validated using in-vitro measurements on six porcine specimens. Validation metrics included intervertebral rotations (L1 to L6) and nucleus pressure in the topmost cranial instrumented disc...
February 14, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28222382/corporeal-illusions-in-chronic-spinal-cord-injuries
#6
Michele Scandola, Salvatore Maria Aglioti, Renato Avesani, Gianettore Bertagnoni, Anna Marangoni, Valentina Moro
While several studies have investigated corporeal illusions in patients who have suffered from a stroke or undergone an amputation, only anecdotal or single case reports have explored this phenomenon after spinal cord injury. Here we examine various different types of bodily misperceptions in a comparatively large group of 49 people with spinal cord injury in the post-acute and chronic phases after the traumatic lesion onset. An extensive battery of questionnaires concerning a variety of body related feelings was administered and the results were correlated to the main clinical variables...
February 17, 2017: Consciousness and Cognition
https://www.readbyqxmd.com/read/28222119/revised-hammersmith-scale-for-spinal-muscular-atrophy-a-sma-specific-clinical-outcome-assessment-tool
#7
Danielle Ramsey, Mariacristina Scoto, Anna Mayhew, Marion Main, Elena S Mazzone, Jacqueline Montes, Roberto de Sanctis, Sally Dunaway Young, Rachel Salazar, Allan M Glanzman, Amy Pasternak, Janet Quigley, Elizabeth Mirek, Tina Duong, Richard Gee, Matthew Civitello, Gihan Tennekoon, Marika Pane, Maria Carmela Pera, Kate Bushby, John Day, Basil T Darras, Darryl De Vivo, Richard Finkel, Eugenio Mercuri, Francesco Muntoni
Recent translational research developments in Spinal Muscular Atrophy (SMA), outcome measure design and demands from regulatory authorities require that clinical outcome assessments are 'fit for purpose'. An international collaboration (SMA REACH UK, Italian SMA Network and PNCRN USA) undertook an iterative process to address discontinuity in the recorded performance of the Hammersmith Functional Motor Scale Expanded and developed a revised functional scale using Rasch analysis, traditional psychometric techniques and the application of clinical sensibility via expert panels...
2017: PloS One
https://www.readbyqxmd.com/read/28221164/positive-and-negative-cues-for-modulating-neurite-dynamics-and-receptor-expression
#8
Melissa Wrobel, Harini Gayathari Sundararaghavan
Many current peripheral nerve repair strategies focus on delivering positive, growth promoting cues (e.g. extracellular matrix, ECM) while eliminating negative, growth inhibiting cues (e.g. chondroitin sulfate proteoglycans, CSPGs) at the injury site. We hypothesized that recapitulating the positive and negative cues of the peripheral nerve injury microenvironment would improve regeneration. First, we tested the effects of a characteristic CSPG, Chondroitin Sulfate A (CSA) on neurite dynamics of dissociated chick embryo dorsal root ganglion (DRG) neurons using time lapse video microscopy...
February 21, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28220824/the-association-between-health-related-quality-of-life-dietary-satisfaction-and-perceived-food-environment-among-japanese-individuals-with-spinal-cord-injury
#9
K Hata, T Inayama, N Yoshiike
STUDY DESIGN: Cross-sectional. OBJECTIVES: To examine the association between health-related quality of life (HRQOL)/dietary satisfaction and perceived food environment in community-dwelling individuals with spinal cord injury (SCI). SETTING: Members of the Spinal Injuries Japan organization. METHODS: Subjects were 2007 Japanese individuals with SCI. A questionnaire conducted in 2015 included items addressing sociodemographic characteristics, HRQOL, dietary satisfaction and eight perceived food environment items...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220823/treatment-of-stress-urinary-incontinence-in-men-with-spinal-cord-injury-minimally-invasive-minimally-effective
#10
J Pannek, J Wöllner
STUDY DESIGN: Retrospective chart review. OBJECTIVES: To assess the outcome of minimally invasive treatment of stress urinary incontinence with alloplastic slings in patients with neurogenic lower urinary tract dysfunction. SETTING: Switzerland. METHODS: The patient database of a tertiary urologic referral center was screened for male patients with SCI who underwent implantation of a suburethral sling between June 2009 and December 2015...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220822/pulmonary-outcomes-following-specialized-respiratory-management-for-acute-cervical-spinal-cord-injury-a-retrospective-analysis
#11
E C Zakrasek, J L Nielson, J J Kosarchuk, J D Crew, A R Ferguson, S L McKenna
STUDY DESIGN: Retrospective analysis. OBJECTIVES: To identify multivariate interactions of respiratory function that are sensitive to spinal cord injury level and pharmacological treatment to promote strategies that increase successful liberation from mechanical ventilation. SETTING: United States regional spinal cord injury (SCI) treatment center. METHODS: Retrospective chart review of patients consecutively admitted to Santa Clara Valley Medical Center between May 2013 and December 2014 for ventilator weaning with C1-C5 American Spinal Injury Association Impairment Scale (AIS) A or B SCI, <3 months from injury and who had a tracheostomy in place...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220821/satisfaction-with-upper-limb-reconstructive-surgery-in-individuals-with-tetraplegia-the-development-and-reliability-of-a-swedish-self-reported-satisfaction-questionnaire
#12
L Bunketorp-Käll, J Wangdell, C Reinholdt, J Fridén
STUDY DESIGN: A questionnaire-based survey. OBJECTIVES: To assess satisfaction after upper limb reconstructive surgery in individuals with tetraplegia and to determine the reliability of a Swedish satisfaction questionnaire. SETTING: A center for advanced reconstruction of extremities, Gothenburg, Sweden. METHODS: Seventy-eight individuals with tetraplegia were invited to participate in the survey assessing satisfaction with the result of surgery across various domains...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220820/testicular-responses-to-hcg-stimulation-at-varying-doses-in-men-with-spinal-cord-injury
#13
W A Bauman, M F La Fountaine, C M Cirnigliaro, S C Kirshblum, A M Spungen
STUDY DESIGN: Prospective. OBJECTIVES: To test whether provocative stimulation of the testes identifies men with chronic spinal cord injury (SCI), a population in which serum testosterone concentrations are often depressed, possibly due to gonadal dysfunction. To accomplish this objective, conventional and lower than the conventional doses of human chorionic gonadotropin (hCG) were administered. METHODS: Thirty men with chronic SCI (duration of injury >1 year; 18 and 65 years old; 16 eugonadal (>12...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220819/the-cutoff-value-of-ossification-of-posterior-longitudinal-ligament-opll-for-early-diagnosis-of-myelopathy-using-somatosensory-evoked-potential-in-cervical-opll-patients
#14
S Y Yoon, T H Park, N L Eun, Y G Park
STUDY DESIGN: Retrospective study. OBJECTIVES: The objective of this study was to find out whether ossification of posterior longitudinal ligament (OPLL) characteristics, including size, shape and subtype, can be used to diagnose myelopathy using somatosensory evoked potential (SEP) in cervical OPLL patients. SETTING: Yonsei University College of Medicine, Seoul, Korea. METHODS: We retrospectively reviewed the medical records of 153 cervical OPLL patients who underwent SEP study...
February 21, 2017: Spinal Cord
https://www.readbyqxmd.com/read/28220804/impact-of-symptomatic-skeletal-events-on-health-care-resource-utilization-and-quality-of-life-among-patients-with-castration-resistant-prostate-cancer-and-bone-metastases
#15
R McKay, B Haider, M S Duh, A Valderrama, M Nakabayashi, M Fiorillo, L Ristovska, L Wen, P Kantoff
BACKGROUND: Data regarding the impact of symptomatic skeletal events (SSEs) on health economics and patient-reported outcomes in men with castration-resistant prostate cancer (CRPC) and bone metastases from a clinical setting are lacking. Hence, this study aimed to quantify the effects of SSEs on health-care resource utilization (HRU), health-related quality of life (HRQoL) and pain in men with CRPC metastasized to bone. METHODS: This cohort study included men with CRPC and bone metastasis treated at a tertiary center during December 1996-July 2015...
February 21, 2017: Prostate Cancer and Prostatic Diseases
https://www.readbyqxmd.com/read/28220638/a-novel-clinical-framework-the-use-of-dispositions-in-clinical-practice-a-person-centred-approach
#16
Matthew Low
This paper explores a novel clinical framework that is underpinned by a specific philosophical perspective of causation and its utility in clinical practice. A dispositional theory of causation may overcome challenges that clinicians face in complex clinical presentations including those that are medically unexplained. Dispositionalism identifies causes not as regular events necessitating an effect but rather phenomena, which are highly complex, context-sensitive, and which tend toward an effect. Diagnostic uncertainty and causal explanation are significant challenges in terms of clinical reasoning, communication, and the overall therapeutic outcome...
February 21, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/28220607/neurological-and-spinal-manifestations-of-the-ehlers-danlos-syndromes
#17
Fraser C Henderson, Claudiu Austin, Edward Benzel, Paolo Bolognese, Richard Ellenbogen, Clair A Francomano, Candace Ireton, Petra Klinge, Myles Koby, Donlin Long, Sunil Patel, Eric L Singman, Nicol C Voermans
The Ehlers-Danlos syndromes (EDS) are a heterogeneous group of heritable connective tissue disorders characterized by joint hypermobility, skin extensibility, and tissue fragility. This communication briefly reports upon the neurological manifestations that arise including the weakness of the ligaments of the craniocervical junction and spine, early disc degeneration, and the weakness of the epineurium and perineurium surrounding peripheral nerves. Entrapment, deformation, and biophysical deformative stresses exerted upon the nervous system may alter gene expression, neuronal function and phenotypic expression...
February 21, 2017: American Journal of Medical Genetics. Part C, Seminars in Medical Genetics
https://www.readbyqxmd.com/read/28220601/multiple-sclerosis-and-nephrolithiasis-a-matched-case-comparative-study
#18
Vishnu Ganesan, Wen Min Chen, Rajat Jain, Shubha De, Manoj Monga
OBJECTIVE: To compare stone composition and serum/urine biochemistries in stone formers with multiple sclerosis (MS) against stone formers without MS and to examine the association between mobility, methods of bladder emptying, and stone formation. MATERIALS AND METHODS: In this retrospective case-control study, we identified patients diagnosed with multiple sclerosis and kidney stone disease who were seen at our institution between 2001 and 2016. For the first part of the study, up to 2 controls (stone formers without a history of MS) were identified for each case and matched on age, body mass index (BMI), and sex...
February 20, 2017: BJU International
https://www.readbyqxmd.com/read/28220287/the-yield-of-initial-conventional-mri-in-115-cases-of-angiographically-confirmed-spinal-vascular-malformations
#19
Amgad El Mekabaty, Carlos A Pardo, Philippe Gailloud
MRI is the primary screening tool for patients with myelopathy. The decision to obtain additional imaging, notably spinal angiography, is generally based on initial MRI findings. This study retrospectively analyzed the yield of initial MRI in a cohort of patients with angiographically confirmed vascular malformations. MRI obtained at symptom onset was available in 115 patients with either high-flow (29 cases) or low-flow (86 cases) vascular malformations. MRI was classified as "positive" when the report mentioned a vascular malformation or "negative" when considered normal or when another diagnosis was suggested...
February 20, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28220067/shared-and-task-specific-muscle-synergies-during-normal-walking-and-slipping
#20
Mohammad Moein Nazifi, Han Ul Yoon, Kurt Beschorner, Pilwon Hur
Falling accidents are costly due to their prevalence in the workplace. Slipping has been known to be the main cause of falling. Understanding the motor response used to regain balance after slipping is crucial to developing intervention strategies for effective recovery. Interestingly, studies on spinalized animals and studies on animals subjected to electrical microstimulation have provided major evidence that the Central Nervous System (CNS) uses motor primitives, such as muscle synergies, to control motor tasks...
2017: Frontiers in Human Neuroscience
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