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https://www.readbyqxmd.com/read/29929175/kyphoplasty-with-purified-silicone-vk100-elastoplasty-to-treat-spinal-lytic-lesions-in-cancer-patients-a-retrospective-evaluation-of-41-cases
#1
Stefano Telera, Alfredo Pompili, Francesco Crispo, Maddalena Giovannetti, Andrea Pace, Veronica Villani, Alessandra Fabi, Isabella Sperduti, Laura Raus
OBJECTIVES: Balloon Kyphoplasty (BKP) for vertebral compression fractures (VCFs) in cancer patients is more challenging than for osteoporotic ones. Cord compressions are frequent and the incidence of complications ten-fold greater. Polymethylmetacrylate (PMMA) is the gold standard material for BKP but has disadvantages: exothermic reaction, short working time, rapid solidification, absence of osteoconduction. VK100 is a mixture of Dimethyl Methylvinyl siloxane and Barium Sulphate. It is elastic, adhesive to bone, leaves 30 min before solidification without exothermic reaction, and shows a stiffness close to the intact vertebrae...
June 15, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29929081/decellularized-peripheral-nerve-supports-schwann-cell-transplants-and-axon-growth-following-spinal-cord-injury
#2
Susana R Cerqueira, Yee-Shuan Lee, Robert C Cornelison, Michaela W Mertz, Rebecca A Wachs, Christine E Schmidt, Mary Bartlett Bunge
Schwann cell (SC) transplantation has been comprehensively studied as a strategy for spinal cord injury (SCI) repair. SCs are neuroprotective and promote axon regeneration and myelination. Nonetheless, substantial SC death occurs post-implantation, which limits therapeutic efficacy. The use of extracellular matrix (ECM)-derived matrices, such as Matrigel, supports transplanted SC survival and axon growth, resulting in improved motor function. Because appropriate matrices are needed for clinical translation, we test here the use of an acellular injectable peripheral nerve (iPN) matrix...
May 28, 2018: Biomaterials
https://www.readbyqxmd.com/read/29929033/central-herniation-induced-by-craniotomy-prompting-air-replacement-for-subdural-fluid-collection-due-to-cerebrospinal-fluid-hypovolemia-a-case-report
#3
Takahide Haku, Yasushi Motoyama, Yoshiaki Takamura, Shuichi Yamada, Ichiro Nakagawa, Young-Su Park, Hiroyuki Nakase
BACKGROUND: Chronic subdural hematoma (CSDH) often occurs in association with cerebrospinal fluid (CSF) hypovolemia. Many cases with CSDH due to CSF hypovolemia and treated by burr-hole surgery have been reported to present with paradoxical deterioration. However, the mechanisms and pathology of deterioration after surgery for CSDH due to CSF hypovolemia remain obscure. CASE DESCRIPTION: We report herein a 62-year-old man with gait disturbance due to subdural fluid collection (SDFC) who underwent burr-hole irrigation and additional craniotomy, in which postoperative deterioration resulted from rapidly progressing central herniation with large amount of air accumulation...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929032/sciatica-caused-by-venous-varix-compression-of-the-sciatic-nerve
#4
Mark A Pacult, Fraser C Henderson, Mathew D Wooster, Abhay K Varma
The authors report the case of a 76 year-old woman presenting with leg pain, numbness and weakness mimicking a lumbosacral radiculopathy. Lumbar spine magnetic resonance imaging (MRI) demonstrated mild root compression but lumbar decompression afforded only transient symptomatic relief. Post-operative MRI of the lumbosacral plexus and sciatic nerve revealed a gluteal venous varix compressing the sciatic nerve just distal to the piriformis muscle. Neurolysis and surgical resection of the offending varix resulted in resolution of her symptoms...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929027/percutaneous-pedicle-screw-fixation-with-bone-cement-augmentation-under-epidural-anesthesia-for-the-treatment-of-k%C3%A3-mmell-s-disease-at-extremely-old-age-a-case-report
#5
Keun Lee, Nitin Adsul, Hyeun-Sung Kim, Yong-Hun Pee, Kwang Lae Lee, Il-Tae Jang
BACKGROUND: In cases of Kümmell's disease without neuro deficit, percutaneous vertebroplasty or Kyphoplasty have achieved short-term favorable outcomes. In the long term, re-collapse of the augmented vertebral body and aggravation of the kyphosis at the index level is often reported. On the other hand, owing to medical comorbidities, the elderly are often not suited for extensive open spine surgery under general anesthesia. CASE DESCRIPTION: A 95-year-old man presented with a one-month history of intractable back pain and gait disturbance...
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29929025/rod-fracture-following-apparently-solid-radiographic-fusion-in-adult-spinal-deformity-patients
#6
Alan H Daniels, J Mason DePasse, Wesley Durand, D Kojo Hamilton, Peter Passias, Han Jo Kim, Themistocles Protopsaltis, Daniel B C Reid, Virginie LaFage, Justin S Smith, Christopher Shaffrey, Munish Gupta, Eric Klineberg, Frank Schwab, Doug Burton, Shay Bess, Christopher Ames, Robert A Hart Issg
No abstract text is available yet for this article.
June 18, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29928993/urate-mitigates-oxidative-stress-and-motor-neuron-toxicity-of-astrocytes-derived-from-als-linked-sod1-g93a-mutant-mice
#7
Rachit Bakshi, Yuehang Xu, Kaly A Mueller, Xiqun Chen, Eric Granucci, Sabrina Paganoni, Ghazaleh Sadri-Vakili, Michael A Schwarzschild
Dominant mutations in an antioxidant enzyme superoxide dismutase-1 (SOD1) cause amyotrophic lateral sclerosis (ALS), an adult-onset neurodegenerative disease characterized by loss of motor neurons. Oxidative stress has also been linked to many of the neurodegenerative diseases and is likely a central mechanism of motor neuron death in ALS. Astrocytes derived from mutant SOD1G93A mouse models or patients play a significant role in the degeneration of spinal motor neurons in ALS through a non-cell-autonomous process...
June 18, 2018: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/29928964/spinal-interleukin-10-produces-antinociception-in-neuropathy-through-microglial-%C3%AE-endorphin-expression-separated-from-antineuroinflammation
#8
Hai-Yun Wu, Xiao-Fang Mao, Xue-Qi Tang, Usman Ali, Evhy Apryani, Hao Liu, Xin-Yan Li, Yong-Xiang Wang
Interleukin 10 (IL-10) is antinociceptive in various animal models of pain without induction of tolerance, and its mechanism of action was generally believed to be mediated by inhibition of neuroinflammation. Here we reported that intrathecal IL-10 injection dose dependently attenuated mechanical allodynia and thermal hyperalgesiain male and female neuropathic rats, with ED50 values of 40.8 ng and 24 ng, and Emax values of 61.5% MPE and 100% MPE in male rats. Treatment with IL-10 specifically increased expression of the β-endorphin (but not prodynorphin) gene and protein in primary cultures of spinal microglia but not in astrocytes or neurons...
June 18, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29928949/impaired-local-translation-of-%C3%AE-actin-mrna-in-ighmbp2-deficient-motoneurons-implications-for-spinal-muscular-atrophy-with-respiratory-distress-smard1
#9
Verena Surrey, Caren Zöller, Alicia Andrea Lork, Mehri Moradi, Stefanie Balk, Benjamin Dombert, Lena Saal-Bauernschubert, Michael Briese, Silke Appenzeller, Utz Fischer, Sibylle Jablonka
Spinal muscular atrophy with respiratory distress type 1 (SMARD1) is a fatal motoneuron disorder in children with unknown etiology. The disease is caused by mutations in the IGHMBP2 gene, encoding a Super Family 1 (SF1)-type RNA/DNA helicase. IGHMBP2 is a cytosolic protein that binds to ribosomes and polysomes, suggesting a role in mRNA metabolism. Here we performed morphological and functional analyses of isolated Ighmbp2 deficient motoneurons to address the question whether the SMARD1 phenotype results from de-regulation of protein biosynthesis...
June 18, 2018: Neuroscience
https://www.readbyqxmd.com/read/29928887/lipopolysaccharide-mediated-inflammatory-priming-potentiates-painful-post-traumatic-trigeminal-neuropathy
#10
Yves Boucher, Nathan Moreau, Annie Mauborgne, Wisam Dieb
We explored the molecular and behavioral effects of a perineural Lipopolysaccharide (LPS)-mediated inflammatory priming on the development and maintenance of painful post-traumatic trigeminal neuropathy (PPTTN) following infra-orbital nerve chronic constriction injury (CCI-IoN) in rats. Rats were pretreated with repetitive perineural injections in the vicinity of the IoN of either LPS or vehicle (Vhcl) before being submitted to CCI-IoN. Orofacial pain-like behaviors (response to Von Frey Filament testing and spontaneous isolated face grooming) were measured during the period of LPS injections (three weeks) and following CCI-IoN surgery (two weeks)...
June 18, 2018: Physiology & Behavior
https://www.readbyqxmd.com/read/29928656/long-term-phase-1-2-intraspinal-stem-cell-transplantation-outcomes-in-als
#11
Stephen A Goutman, Morton B Brown, Jonathan D Glass, Nicholas M Boulis, Karl Johe, Tom Hazel, Merit Cudkowicz, Nazem Atassi, Lawrence Borges, Parag G Patil, Stacey A Sakowski, Eva L Feldman
Objective: Intraspinal human spinal cord-derived neural stem cell (HSSC) transplantation is a potential therapy for amyotrophic lateral sclerosis (ALS); however, previous trials lack controls. This post hoc analysis compared ambulatory limb-onset ALS participants in Phase 1 and 2 (Ph1/2) open-label intraspinal HSSC transplantation studies up to 3 years after transplant to matched participants in Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) and ceftriaxone datasets to provide required analyses to inform future clinical trial designs...
June 2018: Annals of Clinical and Translational Neurology
https://www.readbyqxmd.com/read/29928515/validation-and-cross-cultural-adaptation-of-the-van-lieshout-test-in-an-italian-population-with-cervical-spinal-cord-injury-a-psychometric-study
#12
Giovanni Galeoto, Anna Berardi, Rita De Santis, Laura Di Valentini, Rosmara Beccasio, Maria Auxiliadora Marquez, Maria Luisa Giordano, Domenico Guarino, Marco Tofani
Study design: Psychometric study. Objective: To assess the reliability and validity of the Italian-translated and adapted version of the Van Lieshout test (VLT) in a population of people with cervical spinal cord injury (C-SCI). Setting: Multicenter study in multiple hospitals in Italy. Methods: The original scale was translated from English to Italian according to international guidelines. The internal consistency, test-retest reliability, and responsiveness of the Italian version of the VLT (IT-VLT) were examined...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29928514/direct-withdrawal-of-a-knife-in-the-lumbar-spinal-canal-in-a-patient-without-neurological-deficit-case-report-and-review-of-the-literature
#13
Francisco Ismael Villarreal-García, Pedro Martin Reyes-Fernández, Oscar Armando Martínez-Gutiérrez, Víctor Manuel Peña-Martínez, Rodolfo Morales-Ávalos
Introduction: Stab-wound injuries to the spinal cord are rare and currently, do not have a well-established management in the literature despite its strong association with neurological injury. Case presentation: We report a case of a patient with a stab-wound injury with a knife in the lumbar region, who underwent direct removal in the operating room without surgical exploration. Upon admission, the patient had no neurological deficit. The X-rays and CT scan before removal showed the involvement of >50% of the intramedullary canal at L2...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29928513/characterization-of-spinal-cord-diffusion-tensor-imaging-metrics-in-clinically-asymptomatic-pediatric-subjects-with-incidental-congenital-lesions
#14
Sona Saksena, Mahdi Alizadeh, Devon M Middleton, Chris J Conklin, Laura Krisa, Adam Flanders, M J Mulcahey, Feroze B Mohamed, Scott H Faro
Study design: Retrospective study. Objectives: To perform quantitative DTI measurements of the entire cervical and thoracic spinal cord (SC) in typically developing (TD) pediatric subjects with incidental findings of syringomyelia or hydromyelia on conventional MRI and in a TD population without any abnormalities. Setting: USA. Methods: 26 TD recruited as part of large SC DTI study, four of these had incidental findings...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29928449/primary-cauda-equina-lymphoma-diagnosed-by-nerve-biopsy-a-case-report-and-literature-review
#15
Kayo Suzuki, Taketoshi Yasuda, Toshihito Hiraiwa, Masahiko Kanamori, Tomoatsu Kimura, Yoshiharu Kawaguchi
Primary cauda equina lymphoma (CEL) is a rare malignant tumor among various neoplasms that affects the cauda equina nerve roots. The present case report described the case of a 65-year-old man who presented with cauda equina syndrome with progressive motor palsy in the legs and gait disturbance over the last 5 months. Magnetic resonance (MR) images showed enlargement of the cauda equina occupying the dural sac from the L1-S1 level with isointensity to the spinal cord signal on both T1- and T2-weighted imaging...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928277/gestational-hypothyroxinemia-affects-its-offspring-with-a-reduced-suppressive-capacity-impairing-the-outcome-of-the-experimental-autoimmune-encephalomyelitis
#16
Henny Haensgen, Eduardo Albornoz, María C Opazo, Katherinne Bugueño, Evelyn Liliana Jara Fernández, Rebecca Binzberger, Tomás Rivero-Castillo, Luis F Venegas Salas, Felipe Simon, Claudio Cabello-Verrugio, Alvaro A Elorza, Alexis M Kalergis, Susan M Bueno, Claudia A Riedel
Hypothyroxinemia (Hpx) is a thyroid hormone deficiency (THD) condition highly frequent during pregnancy, which although asymptomatic for the mother, it can impair the cognitive function of the offspring. Previous studies have shown that maternal hypothyroidism increases the severity of experimental autoimmune encephalomyelitis (EAE), an autoimmune disease model for multiple sclerosis (MS). Here, we analyzed the immune response after EAE induction in the adult offspring gestated in Hpx. Mice gestated in Hpx showed an early appearance of EAE symptoms and the increase of all parameters of the disease such as: the pathological score, spinal cord demyelination, and immune cell infiltration in comparison to the adult offspring gestated in euthyroidism...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29928256/bilateral-vestibulopathy-in-superficial-siderosis
#17
Sang-Yeon Lee, Dong-Han Lee, Yun Jung Bae, Jae-Jin Song, Ji Soo Kim, Ja-Won Koo
Background: Superficial siderosis (SS) is a rare condition in which hemosiderin, an iron storage complex, is deposited in neural tissues because of recurrent subarachnoid bleeding. Hemosiderin deposition in the vestibulocochlear nerve (CN VIII), brain, spinal cord and peripheral nerve can cause sensorineural hearing loss (SNHL) and postural imbalance, but much remains unknown about the vestibular manifestations of SS. Objectives: To report the clinical course, cochleovestibular status, and patterns of vestibulopathy during follow-up of a relatively large case series, and to discuss the possible pathophysiological mechanism of vestibular deterioration...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29928101/pubic-symphysis-diastasis-sustained-from-a-waterslide-injury
#18
Michael Williamson, Felice Vanacore, Caroline Hing
Pubic symphysis diastasis injuries typically occur following a high velocity force such as road traffic accidents, horse riding, crush injuries and falls from a height. There are reports of a range of injuries caused by waterslides including spinal fractures, head injuries and vaginal injuries. Here we report the case of a 50-year-old female who suffered a pelvic diastasis injury during the use of a waterslide.
June 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29928093/paraspinal-schwannoma-of-dorsal-ramus-nerve-a-case-report
#19
Kunal Ajay Shah, Ajay Chimanlal Shah
Spinal Schwannomas are benign nerve sheath tumors and the most common intradural extramedullary tumors of the spine, mainly occurring in the cervical and lumbar region. The location distinct from the spinal canal is very rare. We report a rare case of a 45year old male with Schwannoma in the dorsal paraspinal musculature. Complete surgical excision of the lesion was performed with clear margins and neuropathological analysis revealed a Schwannoma. There has been no recurrence after 6 months.
June 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29927859/preoperative-sagittal-spinal-profile-of-adolescent-idiopathic-scoliosis-lenke-types-and-non-scoliotic-adolescents-a-systematic-review-and-meta-analysis
#20
Saba Pasha, Keith Baldwin
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: This study aims to determine the differences in sagittal spinopelvic parameters between adolescent idiopathic scoliosis (AIS) Lenke types and non-scoliotic controls through a systematic review and meta-analysis of the available literature. SUMMARY OF BACKGROUND DATA: AIS classification mainly focuses on frontal curve differences; however, the variations in the sagittal spinopelvic alignment in the current classification system is not fully established...
June 20, 2018: Spine
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