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https://www.readbyqxmd.com/read/29245067/lin28a-functionally-modulates-bupivacaine-induced-dorsal-root-ganglion-neuron-apoptosis-through-trka-activation
#1
Liangsheng Yu, Yuanxu Jiang, Bin Tang
PURPOSE: Lin-28 Homolog A gene (Lin28a) is an important regulator in nerve system. In this study, we investigated the functional mechanism of Lin28a during the process of bupivacaine (BUP)-induced neuronal apoptosis of spinal cord dorsal root ganglion neurons (DRGNs). METHODS: Young mouse DRGNs were cultured in vitro and treated with series concentrations of BUP. Apoptosis was evaluated by TUNEL assay. Corresponding Lin28a mRNA and protein expressions were evaluated by qRT-PCR and western blot (WB) assays...
December 12, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29244892/alterations-in-the-masticatory-system-in-patients-with-amyotrophic-lateral-sclerosis
#2
Nina Riera-Punet, Jordi Martinez-Gomis, Andrés Paipa, Monica Povedano, Maria Peraire
AIMS: To determine the effect of amyotrophic lateral sclerosis (ALS) on aspects of masticatory function and to assess the relationship between ALS and the prevalence of traumatic mucosal lesions caused by oral self-injury. METHODS: A total of 153 ALS patients and 23 control subjects participated in this cross-sectional study. Clinical characteristics including site of onset, medication, type of feeding, and use of noninvasive mechanical ventilation were recorded...
December 15, 2017: Journal of Oral & Facial Pain and Headache
https://www.readbyqxmd.com/read/29244850/intensity-matters-therapist-dependent-dose-of-spinal-transcutaneous-electrical-nerve-stimulation
#3
Diego Serrano-Muñoz, Julio Gómez-Soriano, Elisabeth Bravo-Esteban, María Vázquez-Fariñas, Julian Taylor, Juan Avendaño-Coy
The intensity used during transcutaneous electrical nerve stimulation (TENS) in both, clinical practice and research studies, is often based on subjective commands such as "strong but comfortable sensation". There is no consensus regarding the effectiveness dose of TENS. The objective was to determine the difference in the effect of spinal TENS on soleus H-reflex modulation when applied by two therapists instructed to apply the stimulation at a "strong but comfortable" intensity. Twenty healthy volunteers divided into two groups: Therapist 1 (n = 10) and Therapist 2 (n = 10)...
2017: PloS One
https://www.readbyqxmd.com/read/29244816/treatment-with-albumin-hydroxyoleic-acid-complex-restores-sensorimotor-function-in-rats-with-spinal-cord-injury-efficacy-and-gene-expression-regulation
#4
Gerardo Avila-Martin, Manuel Mata-Roig, Iriana Galán-Arriero, Julian S Taylor, Xavier Busquets, Pablo V Escribá
Sensorimotor dysfunction following incomplete spinal cord injury (SCI) is often characterized by paralysis, spasticity and pain. Previously, we showed that intrathecal (i.t.) administration of the albumin-oleic acid (A-OA) complex in rats with SCI produced partial improvement of these symptoms and that oral 2-hydroxyoleic acid (HOA, a non-hydrolyzable OA analogue), was efficacious in the modulation and treatment of nociception and pain-related anxiety, respectively. Here we observed that intrathecal treatment with the complex albumin-HOA (A-HOA) every 3 days following T9 spinal contusion injury improved locomotor function assessed with the Rotarod and inhibited TA noxious reflex activity in Wistar rats...
2017: PloS One
https://www.readbyqxmd.com/read/29244790/lentivirus-mediated-silencing-of-the-ptc1-and-ptc2-genes-promotes-recovery-from-spinal-cord-injury-by-activating-the-hedgehog-signaling-pathway-in-a-rat-model
#5
Ya-Dong Zhang, Zhong-Sheng Zhu, Dong Zhang, Zhen Zhang, Bin Ma, Shi-Chang Zhao, Feng Xue
This study aimed to investigate the effect of Patched-1 (PTC1) and PTC2 silencing in a rat model, on Hedgehog (Hh) pathway-mediated recovery from spinal cord injury (SCI). An analytical emphasis on the relationship between the sonic hedgehog (Shh) pathway and nerve regeneration was explored. A total of 126 rats were divided into normal, sham, SCI, negative control (NC), PTC1-RNAi, PTC2-RNAi and PTC1/PTC2-RNAi groups. The Basso, Beattie and Bresnahan (BBB) scale was employed to assess hind limb motor function...
December 15, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29244782/efficacy-of-blunt-force-trauma-a-novel-mechanical-cervical-dislocation-device-and-a-non-penetrating-captive-bolt-device-for-on-farm-euthanasia-of-pre-weaned-kits-growers-and-adult-commercial-meat-rabbits
#6
Jessica L Walsh, Aaron Percival, Patricia V Turner
The commercial meat rabbit industry is without validated on-farm euthanasia methods, potentially resulting in inadequate euthanasia protocols. We evaluated blunt force trauma (BFT), a mechanical cervical dislocation device (MCD), and a non-penetrating captive bolt device (NPCB) for euthanasia of pre-weaned kits, growers, and adult rabbits. Trials were conducted on three commercial meat rabbit farms using 170 cull rabbits. Insensibility was assessed by evaluating absence of brainstem and spinal reflexes, rhythmic breathing, and vocalizations...
December 15, 2017: Animals: An Open Access Journal From MDPI
https://www.readbyqxmd.com/read/29244699/acute-and-rapid-development-of-spontaneous-spinal-epidural-hematoma-associated-with-combined-aspirin-dipyridamole-therapy-a-case-report
#7
Kent Yamaguchi, Justin Mathew, James M Lhi, Don Young Park
CASE: Spontaneous spinal epidural hematoma (SSEH) is a known, although rare, clinical entity that may be challenging to diagnose. This case report describes the rapid development of a large SSEH in an elderly patient on aspirin-dipyridamole combination therapy after she shifted her position in bed. Magnetic resonance imaging obtained 4 hours after the onset of symptoms demonstrated a large spinal epidural hematoma that extended from T4 to L1. CONCLUSION: With early diagnosis, the patient was successfully treated with a laminectomy and evacuation of the hematoma, and there was full neurological recovery...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244696/selective-spinal-fusion-for-neuromuscular-scoliosis-in-a-patient-with-pompe-disease-a-case-report-and-review-of-the-literature
#8
Atsushi Tanida, Shinji Tanishima, Tokumitsu Mihara, Aya Narita, Yoshihiro Maegaki, Hideki Nagashima
CASE: A 16-year-old girl with Pompe disease underwent surgery for scoliosis. She had been able to walk without any assistance, and kept her balance by swinging her waist. Therefore, we performed posterior selective spinal correction and fusion to avoid any adverse effects on walking ability that could occur with immobilization of the lumbosacral spine. After surgery, she was highly satisfied with her ability to perform the activities of daily living. CONCLUSION: For nonambulatory patients with scoliosis and Pompe disease, long fusion from the upper thoracic spine to the pelvis is generally required...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244695/recurrent-hip-dislocation-following-total-hip-arthroplasty-treatment-with-sagittal-spinal-deformity-correction-a-case-report
#9
Yoon-Je Cho, Jung-Hee Lee, Sung Joon Shin, Kyung-Chung Kang
CASE: A 63-year-old woman with lumbar degenerative kyphosis who had undergone total hip arthroplasty 34 months previously presented after having multiple episodes of anterior hip dislocation; evaluation also revealed progressive osteoarthritis in the contralateral hip joint. The patient was managed with sagittal correction with pedicle subtraction osteotomy, which resulted in optimal positioning of the acetabular component and an upright posture. The patient had had no additional dislocation events in the involved hip and had reduced pain in the contralateral hip at the time of the 2-year follow-up...
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244682/spinal-epidural-hematoma-rare-but-potentially-devastating
#10
Ronald W Lindsey, Allan Harper
No abstract text is available yet for this article.
January 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244666/natural-correction-and-adaptation-of-a-severely-deformed-sacral-dome-in-an-adolescent-with-isthmic-spondylolisthesis-a-case-report
#11
Kazuta Yamashita, Kosaku Higashino, Toshinori Sakai, Yoichiro Takata, Akihiro Nagamachi, Koichi Sairyo
CASE: A spinal deformity with wedging of L5 and rounding of the surface of the sacral dome is very common in pediatric patients with spondylolisthesis at the L5 vertebral level, and it has been well documented that severe spondylolisthesis is a good indication for spinal arthrodesis. We report the natural correction and adaptation of a severely deformed sacral dome with slippage (40.8%) in a pediatric patient with nonoperative treatment. CONCLUSION: Vertebral deformity in children can be reversible...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244663/scapular-winging-caused-by-combined-palsy-of-the-spinal-accessory-nerve-and-the-long-thoracic-nerve-a-case-report
#12
Kentaro Ago, Noboru Matsumura, Takuji Iwamoto, Kazuki Sato, Masaya Nakamura, Morio Matsumoto
CASE: A 37-year-old man with scapular winging, caused by combined palsy of the spinal accessory nerve and the long thoracic nerve, was successfully treated with a pectoralis major transfer to substitute for the serratus anterior muscle, and with levator scapulae and rhomboid muscle transfers to substitute for the trapezius muscle. CONCLUSION: The serratus anterior paralysis was thought to have occurred secondary to traction of the long thoracic nerve by the unsupported scapula following the spinal accessory nerve palsy...
April 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244235/new-therapy-for-refractory-chronic-mechanical-low-back-pain-restorative-neurostimulation-to-activate-the-lumbar-multifidus-one-year-results-of-a-prospective-multicenter-clinical-trial
#13
REVIEW
Kristiaan Deckers, Kris De Smedt, Bruce Mitchell, David Vivian, Marc Russo, Peter Georgius, Matthew Green, John Vieceli, Sam Eldabe, Ashish Gulve, Jean-Pierre van Buyten, Iris Smet, Vivek Mehta, Shankar Ramaswamy, Ganesan Baranidharan, Richard Sullivan, Robert Gassin, James Rathmell, Chris Gilligan
OBJECTIVES: The purpose of the international multicenter prospective single arm clinical trial was to evaluate restorative neurostimulation eliciting episodic contraction of the lumbar multifidus for treatment of chronic mechanical low back pain (CMLBP) in patients who have failed conventional therapy and are not candidates for surgery or spinal cord stimulation (SCS). MATERIALS AND METHODS: Fifty-three subjects were implanted with a neurostimulator (ReActiv8, Mainstay Medical Limited, Dublin, Ireland)...
December 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29244102/association-of-opioid-usage-with-spinal-cord-stimulation-outcomes
#14
Ashwini D Sharan, Jonathan Riley, Steven Falowski, Jason E Pope, Allison T Connolly, Edward Karst, Nirav Dalal, David A Provenzano
Study Design: Observational study using insurance claims. Objective: To quantify opioid usage leading up to spinal cord stimulation (SCS) and the potential impact on outcomes of SCS. Setting: SCS is an interventional therapy that often follows opioid usage in the care continuum for chronic pain. Methods: This study identified SCS patients using the Truven Health MarketScan databases from January 2010 to December 2014...
December 13, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29244035/interprofessional-collaboration-and-peer-mentors-for-bowel-education-in-spinal-cord-injury-a-case-consultation
#15
Ralph D Cabigon, Elizabeth Wojciechowski, Lisa Rosen, David Miller, Cristina Mix, David Chen
BACKGROUND: Evidence shows that having a bowel management program prevents rehospitalization postacute rehabilitation discharge for persons with a spinal cord injury (SCI). Peer mentors have been used to assist patients in managing their care. PURPOSE: The aim of the study was to illustrate how interprofessional collaboration led to utilizing resources of the inpatient rehabilitation facility's peer mentor program and incorporating peer mentors into bowel education for persons with SCI...
December 13, 2017: Rehabilitation Nursing: the Official Journal of the Association of Rehabilitation Nurses
https://www.readbyqxmd.com/read/29243997/transdural-approach-to-resection-of-retro-odontoid-cysts-in-elderly-patients-report-of-3-cases
#16
Karthik Madhavan, Lee Onn Chieng, Brandon G Gaynor, Allan D Levi
Retro-odontoid cysts that arise from the tectorial membrane are uncommon lesions that can occur in elderly patients. They arise secondary to degenerative changes, including calcium pyrophosphate deposition within the ligaments. Surgical treatment is indicated when these lesions result in intractable pain, instability, and/or myelopathy. Several surgical techniques to treat this condition exist, but the optimal approach in elderly patients with comorbidities remains controversial. Here, the authors present a case series of 3 patients who underwent successful resection of a retro-odontoid lesion performed through a transdural approach...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29243804/notalgia-paresthetica-a-review-for-dermatologists
#17
REVIEW
Matthew Howard, Lukas Sahhar, Frank Andrews, Ralph Bergman, Douglas Gin
Notalgia paresthetica (NP) is an underdiagnosed condition that presents with unilateral pruritus medial to the scapula on the midback with or without an associated hyperpigmented or hypopigmented macule. There is a paucity of recent reviews on this chronic cutaneous neuropathy in peer-reviewed journals. Current theories propose the condition is likely multifactorial, including spinal entrapment and muscular compressive neuropathy. An extensive literature review was performed by searching the MEDLINE database to review all published works on notalgia paresthetica...
December 15, 2017: International Journal of Dermatology
https://www.readbyqxmd.com/read/29243586/symptomatic-lumbosacral-transitional-vertebra-a-review-of-the-current-literature-and-clinical-outcomes-following-steroid-injection-or-surgical-intervention
#18
Emil Kongsted Holm, Cody Bünger, Casper Bindzus Foldager
Bertolotti's syndrome (BS) refers to the possible association between the congenital malformation lumbosacral transitional vertebra (LSTV), and low back pain (LBP). Several treatments have been proposed including steroid injections, resections of the LSTV, laminectomy, and lumbar spinal fusion. The aim of this review was to compare the clinical outcomes in previous trials and case reports for these treatments in patients with LBP and LSTV. A PubMed search was conducted. We included English studies of patients diagnosed with LSTV treated with steroid injection, laminectomy, spinal fusion or resection of the transitional articulation...
2017: SICOT-J
https://www.readbyqxmd.com/read/29243458/prevalence-of-life-supporting-prolonged-invasive-ventilation-support-in-finland
#19
Waltteri Siirala, Aki Vainionpää, Annette Kainu, Jaana Korpela, Klaus Olkkola, Riku Aantaa
BACKGROUND: There is no comprehensive data in our country on the prevalence of life-supporting prolonged invasive ventilation support. The objective of the survey was to clarify in all hospital districts of continental Finland the prevalence of patients who were dependent on invasive ventilation support, and the disease leading to the treatment. PATIENTS AND METHODS: The KOTIVEHNO 2015 survey was carried out as population-based cross-sectional study by sending a questionnaire to all doctors in charge of prolonged invasive ventilation support...
2017: Duodecim; Lääketieteellinen Aikakauskirja
https://www.readbyqxmd.com/read/29243319/zebrafish-rfx4-controls-dorsal-and-ventral-midline-formation-in-the-neural-tube
#20
Irina Sedykh, Abigail N Keller, Baul Yoon, Laura Roberson, Oleg V Moskvin, Yevgenya Grinblat
BACKGROUND: Rfx winged-helix transcription factors, best known as key regulators of core ciliogenesis, also play ciliogenesis-independent roles during neural development. Mammalian Rfx4 controls neural tube morphogenesis via both mechanisms. RESULTS: We set out to identify conserved aspects of rfx4 gene function during vertebrate development and to establish a new genetic model in which to analyze these mechanisms further. To this end, we have generated frame-shift alleles in the zebrafish rfx4 locus using CRISPR/Cas9 mutagenesis...
December 15, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
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