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https://www.readbyqxmd.com/read/27927893/paraprotein-related-kidney-disease-attack-of-the-killer-m-proteins
#1
Mark A Perazella, Kevin W Finkel
Paraproteins are monoclonal Igs or their components (light or heavy chains) that are produced by a clonal population of mature B cells, most commonly plasma cells. These paraproteins or monoclonal proteins are secreted into the blood and subsequently filtered by the glomerulus before entering into urine, where they can cause various types of kidney disease, including both glomerular and tubulointerstitial injuries. Furthermore, a monoclonal protein that causes a specific glomerular or tubulointerstitial lesion in a human can reproducibly cause the same pathology when injected into an animal, supporting unique paraprotein characteristics...
December 7, 2016: Clinical Journal of the American Society of Nephrology: CJASN
https://www.readbyqxmd.com/read/27672090/initiation-of-erythropoiesis-stimulating-agents-and-outcomes-a-nationwide-observational-cohort-study-in-anaemic-chronic-kidney-disease-patients
#2
Marie Evans, Juan-Jesus Carrero, Rino Bellocco, Peter Barany, Abdul R Qureshi, Astrid Seeberger, Stefan H Jacobson, Britta Hylander-Rössner, Andrea Rotnitzky, Arvid Sjölander
BACKGROUND: In 2012, new clinical guidelines were introduced for use of erythropoiesis-stimulating agents (ESA) in chronic kidney disease (CKD) patients, recommending lower haemoglobin (Hb) target levels and thresholds for ESA initiation. These changes resulted in lower blood levels in these patients. However, there is limited evidence on just when ESA should be initiated and the safety of a low Hb initiation policy. METHODS: In this observational inception cohort study, Swedish, nephology-referred, ESA-naïve CKD patients (n = 6348) were enrolled when their Hb dropped below 12...
September 26, 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26604993/virtual-patients-in-continuing-medical-education-and-residency-training-a-pilot-project-for-acceptance-analysis-in-the-framework-of-a-residency-revision-course-in-pediatrics
#3
Ronny Lehmann, Benjamin Hanebeck, Stephan Oberle, Anke Simon, Daniela Choukair, Burkhard Tönshoff, Sören Huwendiek
AIM: Virtual patients (VPs) are a one-of-a-kind e-learning resource, fostering clinical reasoning skills through clinical case examples. The combination with face-to-face teaching is important for their successful integration, which is referred to as "blended learning". So far little is known about the use of VPs in the field of continuing medical education and residency training. The pilot study presented here inquired the application of VPs in the framework of a pediatric residency revision course...
2015: GMS Zeitschrift Für Medizinische Ausbildung
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