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https://www.readbyqxmd.com/read/29767323/prevalence-and-risk-factors-related-to-haloperidol-use-for-delirium-in-adult-intensive-care-patients-the-multinational-aid-icu-inception-cohort-study
#1
Marie O Collet, Jesús Caballero, Romain Sonneville, Fernando A Bozza, Peter Nydahl, Anna Schandl, Hilden Wøien, Giuseppe Citerio, Mark van den Boogaard, Johanna Hästbacka, Matthias Haenggi, Kirsten Colpaert, Louise Rose, Marija Barbateskovic, Theis Lange, Aksel Jensen, Martin B Krog, Ingrid Egerod, Helle L Nibro, Jørn Wetterslev, Anders Perner
PURPOSE: We assessed the prevalence and variables associated with haloperidol use for delirium in ICU patients and explored any associations of haloperidol use with 90-day mortality. METHODS: All acutely admitted, adult ICU patients were screened during a 2-week inception period. We followed the patient throughout their ICU stay and assessed 90-day mortality. We assessed patients and their variables in the first 24 and 72 h in ICU and studied their association together with that of ICU characteristics with haloperidol use...
May 16, 2018: Intensive Care Medicine
https://www.readbyqxmd.com/read/29688246/drug-consumption-and-futile-medication-prescribing-in-the-last-year-of-life-an-observational-study
#2
D Curtin, D O'Mahony, P Gallagher
Background: the last year of life for many older people is associated with high symptom burden and frequent hospitalizations. Hospital physicians have an opportunity to prioritize essential medications and deprescribe potentially futile medications. Objective: to measure medication consumption during hospitalization in the last year of life and the prevalence of potentially inappropriate medications (PIMs) at hospital discharge. Design: retrospective chart review...
April 23, 2018: Age and Ageing
https://www.readbyqxmd.com/read/29670200/effectiveness-of-traditional-chinese-medicineas-as-an-adjunct-therapy-for-refractory-schizophrenia-a-systematic-review-and-meta-analysis
#3
Yan-Yan Wei, Wan-Fu Lin, Tian-Hong Zhang, Yun-Xiang Tang, Ji-Jun Wang, Mao-Feng Zhong
Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-analysis to investigate the effectiveness of TCM in combination with antipsychotics for refractory schizophrenia. Fourteen articles involving 1725 patients published as of December 2016 were included which compared antipsychotic therapies to either TCM alone, or TCM as an adjunctive therapy...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29645261/determinants-of-quality-of-life-among-people-diagnosed-with-schizophrenia-at-outpatient-clinics
#4
Abd Alhadi Hasan, Hussein Tumah
PURPOSE: The study examines the determinants of the quality of life (QoL) among outpatients with schizophrenia in Jordan. DESIGN AND METHODS: A cross-sectional study design was used with 157 people with schizophrenia treated in outpatient clinics. Demographic, clinical and psychosocial variables were examined for their influence on QoL. Data were analysed with descriptive statistics, Pearson product moment correlation and stepwise forward multiple linear regression...
April 12, 2018: Perspectives in Psychiatric Care
https://www.readbyqxmd.com/read/29582531/metabolic-control-of-type-1-diabetes-in-youth-with-autism-spectrum-disorder-a-multicenter-diabetes-patienten-verlaufsdokumentation-analysis-based-on-61-749-patients-up-to-20-years-of-age
#5
J-F Lemay, S Lanzinger, D Pacaud, P L Plener, A Fürst-Burger, T Biester, D Hilgard, E Lilienthal, A Galler, G Berger, R W Holl
BACKGROUND: A paucity of reports in the literature exists concerning the co-existence between autism spectrum disorder (ASD) and type 1 diabetes (T1D). OBJECTIVE: To compare clinical characteristics, diabetes management and metabolic control in youth with T1D and ASD (T1D-ASD) with youth without ASD (T1D-non ASD). METHODS: Using the German/Austrian diabetes patient follow-up registry, this study analyzed aggregated data from the last available year of observation for each patient with T1D, ages 1-20 with consistent data on insulin regimen and glycated hemoglobin (A1C), between January, 2005 and March, 2017...
March 26, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29570875/adenosine-a-2a-receptors-modulate-the-dopamine-d-2-receptor-mediated-inhibition-of-synaptic-transmission-in-the-mouse-prefrontal-cortex
#6
Joana I Real, Ana Patrícia Simões, Rodrigo A Cunha, Samira G Ferreira, Daniel Rial
Prefrontal cortex (PFC) circuits are modulated by dopamine acting on D1 - and D2 -like receptors, which are pharmacologically exploited to manage neuropsychiatric conditions. Adenosine A2A receptors (A2 A R), also control PFC-related responses and A2 A R antagonists are potential anti-psychotic drugs. Since tight antagonistic A2 A R-D2 R and synergistic A2 A R-D1 R interactions occur in other brain regions, we now investigated the cross-talk between A2 A R and D1 /D2 R controlling synaptic transmission between layers II/III and V in mouse PFC coronal slices...
March 23, 2018: European Journal of Neuroscience
https://www.readbyqxmd.com/read/29559372/a-double-dissociation-between-two-psychotic-phenotypes-periodic-catatonia-and-cataphasia
#7
Foucher Jack René, Zhang Yi Fan, Roser Mathilde, Lamy Julien, De Sousa Paulo Loureiro, Weibel Sébastien, Vidailhet Pierre, Mainberger Olivier, Berna Fabrice
Schizophrenia as a single liability model was confronted to the multiple psychotic phenotypes model proposed by the Wernicke-Kleist-Leonhard school, focusing on two: periodic catatonia (PC) and cataphasia (C). Both are stable and heritable psychotic phenotypes with no crossed liability and are coming with the buildup of specific residual symptoms: impairment of psychomotricity for PC and a specific disorganization of thought and language in C. Regional cerebral blood flow (rCBF) was used as a biomarker. We attempted to refute the single phenotype model by looking at relevant and specific rCBF anomalies for PC and C, that would exceed anomalies in common relative to controls (CTR), i...
March 17, 2018: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29464048/src-is-the-primary-target-of-aripiprazole-an-atypical-antipsychotic-drug-in-its-anti-tumor-action
#8
Mi Seon Kim, Byong Chul Yoo, Woo Seok Yang, Sang Yun Han, Deok Jeong, Jun Min Song, Kyung Hee Kim, Adithan Aravinthan, Ji Hye Kim, Jong-Hoon Kim, Seung Cheol Kim, Jae Youl Cho
Aripiprazole (ARP) is an atypical anti-psychotic drug widely used to treat schizophrenia and bipolar disorder. The pharmacological effects of ARP on cancer cells are still poorly understood. In this study, anti-cancer effects of ARP on various malignant tumor cells and its molecular mechanism were further carefully examined by using cell proliferation assay, xenograft mouse model, immunoblotting analysis, migration assay, luciferase reporter gene assay, kinase assay, and overexpression strategy. Treatment with ARP induced cytotoxicity in U251 glioma cells, MKN-1 gastric adenosquamous carcinoma cells, and CT26 colon carcinoma cells...
January 19, 2018: Oncotarget
https://www.readbyqxmd.com/read/29438977/post-transcriptional-regulation-of-ugt2b10-hepatic-expression-and-activity-by-alternative-splicing
#9
Adrien Labriet, Eric P Allain, Michèle Rouleau, Yannick Audet-Delage, Lyne Villeneuve, Chantal Guillemette
The detoxification enzyme UDP-glucuronosyltransferase UGT2B10 is specialized in the N-linked glucuronidation of many drugs and xenobiotics. Preferred substrates possess tertiary aliphatic amines and heterocyclic amines, such as tobacco carcinogens and several antidepressants and antipsychotics. We hypothesized that alternative splicing (AS) constitutes a means to regulate steady-state levels of UGT2B10 and enzyme activity. We established the transcriptome of UGT2B10 in normal and tumoral tissues of multiple individuals...
May 2018: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/29422863/-n-n-butyl-haloperidol-iodide-a-derivative-of-the-anti-psychotic-haloperidol-antagonizes-hypoxia-reoxygenation-injury-by-inhibiting-an-egr-1-ros-positive-feedback-loop-in-h9c2-cells
#10
Ting Sun, Yanmei Zhang, Shuping Zhong, Fenfei Gao, Yicun Chen, Bin Wang, Wenfeng Cai, Zhaojing Zhang, Weiqiu Li, Shishi Lu, Fuchun Zheng, Ganggang Shi
Early growth response-1 (Egr-1), a transcription factor which often underlies the molecular basis of myocardial ischemia/reperfusion (I/R) injury, and oxidative stress, is key to myocardial I/R injury. Silent information regulator of transcription 1(SIRT1) not only interacts with and is inhibited by Egr-1, but also downregulates reactive oxygen species (ROS) via the Forkhead box O1(FOXO1)/manganese superoxide dismutase (Mn-SOD) signaling pathway. N -n-butyl haloperidol iodide (F2 ), a new patented compound, protects the myocardium against myocardial I/R injury in various animal I/R models in vivo and various heart-derived cell hypoxia/reoxygenation (H/R) models in vitro ...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29387559/inadvertent-placement-of-a-urinary-catheter-into-the-ureter-a-report-of-3-cases-and-review-of-the-literature
#11
Rui Luo, Song Liang Lee, Foo Cheong Ng, Li-Tsa Koh
We describe three cases of inadvertent placement of the urinary catheter into the ureter. An 85-year-old gentleman on long-term indwelling catheter (IDC) for neurogenic bladder presented with fever and right flank pain. CT of abdomen and pelvis demonstrated the tip of the IDC to be located within the right vesicoureteric junction with acute right hydronephrosis and acute pyelonephritis. A 74-year-old woman, on long-term IDC for neurogenic bladder was found to have hydronephrosis on ultrasound imaging. Contrast-enhanced CT intravenous pyelography done subsequently showed the IDC was in the right distal ureter...
October 2017: Asian Journal of Urology
https://www.readbyqxmd.com/read/29358088/isogenic-fus-egfp-ipsc-reporter-lines-enable-quantification-of-fus-stress-granule-pathology-that-is-rescued-by-drugs-inducing-autophagy
#12
Lara Marrone, Ina Poser, Ian Casci, Julia Japtok, Peter Reinhardt, Antje Janosch, Cordula Andree, Hyun O Lee, Claudia Moebius, Ellen Koerner, Lydia Reinhardt, Maria Elena Cicardi, Karl Hackmann, Barbara Klink, Angelo Poletti, Simon Alberti, Marc Bickle, Andreas Hermann, Udai Bhan Pandey, Anthony A Hyman, Jared L Sterneckert
Perturbations in stress granule (SG) dynamics may be at the core of amyotrophic lateral sclerosis (ALS). Since SGs are membraneless compartments, modeling their dynamics in human motor neurons has been challenging, thus hindering the identification of effective therapeutics. Here, we report the generation of isogenic induced pluripotent stem cells carrying wild-type and P525L FUS-eGFP. We demonstrate that FUS-eGFP is recruited into SGs and that P525L profoundly alters their dynamics. With a screening campaign, we demonstrate that PI3K/AKT/mTOR pathway inhibition increases autophagy and ameliorates SG phenotypes linked to P525L FUS by reducing FUS-eGFP recruitment into SGs...
February 13, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29328360/metabolic-side-effects-in-patients-using-atypical-antipsychotic-medications-during-hospitalization
#13
Gül Dikeç, Leyla Baysan Arabaci, Gülçin Bölük Uzunoglu, Selin Demet Mizrak
The current research evaluated metabolic side effects in inpatients (N = 271) using atypical antipsychotic medications in a psychiatric hospital in Turkey between June and December 2016. Data were collected via an information form created after reviewing the literature at the time of patients' hospitalization and discharge. According to the analysis, 73.8% of patients stated they experienced side effects from antipsychotic medications and 20.7% of patients experienced weight gain. A statistical difference was detected among body mass index, waist circumference, diastolic blood pressure, and heart rate during patient hospitalization and discharge...
April 1, 2018: Journal of Psychosocial Nursing and Mental Health Services
https://www.readbyqxmd.com/read/29310919/increased-complications-for-schizophrenia-and-bipolar-disorder-patients-undergoing-total-joint-arthroplasty
#14
Michael M Kheir, You Na P Kheir, Timothy L Tan, Colin T Ackerman, Alexander J Rondon, Antonia F Chen
BACKGROUND: Although it has been shown that anxiety and depression are associated with increased complications after total joint arthroplasty (TJA), the outcomes of TJA in patients with a history of psychosis are unknown. This study evaluated the influence of bipolar and schizophrenic disorders on complications after TJA, particularly aseptic and septic revisions. METHODS: A retrospective review of 156 TJAs (125 primaries and 31 revisions) was performed at a single institution from 2000 to 2015...
December 14, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29247391/trazodone-alleviates-both-dyskinesia-and-psychosis-in-the-parkinsonian-marmoset-model-of-parkinson-s-disease
#15
Adjia Hamadjida, Stephen G Nuara, Jim C Gourdon, Philippe Huot
Trazodone is a clinically available anti-depressant that exhibits affinity for serotonin 1A and 2A receptors, as well as for alpha-adrenoceptors, suggesting that it may be useful to treat L-3,4-dihydroxyphenylalanine (L-DOPA)-induced dyskinesia and psychosis that are encountered in advanced Parkinson's disease (PD). Here, we investigated the anti-dyskinetic and anti-psychotic effects of trazodone in the parkinsonian non-human primate. 6 common marmosets were rendered parkinsonian by administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)...
December 15, 2017: Journal of Neural Transmission
https://www.readbyqxmd.com/read/29195803/-validation-of-the-french-version-of-the-self-evaluation-of-negative-symptoms-sns
#16
C Hervochon, V Bourgeois, M Rotharmel, J-B Duboc, B Le Goff, P Quesada, D Campion, S Dollfus, O Guillin
INTRODUCTION: Schizophrenia is a disorder affecting 1% of the population and is associated with severe functional impairment. Negative symptoms are responsible for the majority of this impairment, and many patients with schizophrenia have negative symptoms. However, their evaluation is still a challenge. Thus, standardized assessments are needed to facilitate identification of these symptoms. Many tools have been developed, but most are based on observer ratings. Self-evaluation can provide an additional outcome measure and allow patients to be more engaged in their treatment...
November 28, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29192946/-aripiprazole-induced-hyperhidrosis-two-case-reports
#17
Adarsh Vohra
Many drugs including anti-depressants and anti-psychotics are known to cause excessive sweating (hyperhidrosis). Hyperhidrosis may be caused by drugs acting at the hypothalamus, spinal thermoregulatory centres, and sympathetic ganglia or at the eccrine-neuroeffector junction. Hyperhidrosis can be distressing and embarrassing symptom, which if not addressed properly, may lead to non-concordance to medication. Two female patients are reported here who developed hyperhidrosis with aripiprazole. Both the patients stopped experiencing hyperhidrosis after their aripiprazole was discontinued...
2017: Türk Psikiyatri Dergisi, Turkish Journal of Psychiatry
https://www.readbyqxmd.com/read/29165075/preferential-formulation-of-second-generation-antipsychotic-asenapine-as-inclusion-complex-with-sulphobutylether-%C3%AE-cd-captisol-in-vitro-and-in-vivo-evaluation
#18
Amelia Makarand Avachat, Juilee A Kulkarni, Charul M Avachat, Rohan Pradhan, Tushar S Suryawanshi, E M Khan, Elvis A F Martis, Evans C Coutinho, Subhash Padhye
Asenapine is an anti-psychotic agent approved by the US-FDA for treatment of acute schizophrenia and manic or bipolar I disorder in adults. It is poorly absorbed when administered orally, hence exhibits poor oral bioavailability, which limits its use in clinical practice. Consequently, enhancement in its solubility through complexation with three different cyclodextrins, viz. βCD (β cyclodextrin), HPβCD (Hydroxypropyl β cyclodextrin) and sulphobutylether-βCD (Captisol®) was attempted and compared. Kneading method was used for preparation of inclusion complexes which were characterized by FTIR, DSC, and XRD methods...
November 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/29144549/zuclopenthixol-dihydrochloride-for-schizophrenia
#19
REVIEW
Edward J Bryan, Marie Ann Purcell, Ajit Kumar
BACKGROUND: Oral zuclopenthixol dihydrochloride (Clopixol) is an anti-psychotic treatment for people with psychotic symptoms, especially those with schizophrenia. It is associated with neuroleptic malignant syndrome, a prolongation of the QTc interval, extra-pyramidal reactions, venous thromboembolism and may modify insulin and glucose responses. OBJECTIVES: To determine the effects of zuclopenthixol dihydrochloride for treatment of schizophrenia. SEARCH METHODS: We searched the Cochrane Schizophrenia Group's Trials Register (latest search 09 June 2015)...
November 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29128790/the-antipsychotic-like-effects-in-rodents-of-yqa31-involve-dopamine-d3-and-5-ht1a-receptor
#20
Hong-Yan Gou, Xue Sun, Fei Li, Zhi-Yuan Wang, Ning Wu, Rui-Bin Su, Bin Cong, Jin Li
BACKGROUND: We previously reported that YQA31 is a dopamine D3 receptor antagonist with modest 5-HT1A receptor affinity and that it exhibits antipsychotic properties in animal models of schizophrenia. However, the contributions of D3 and 5-HT1A receptors in the anti-psychotic effects of YQA31 are not clear. The current study evaluated the role of these two receptors in the effect of YQA31 on the hyperactivity and novel object recognition deficit in mice. METHODS: We used dopamine D3 receptor knockout mice and 5-HT1A receptor antagonist WAY100635 pretreatment, respectively, to investigate the involvement of these receptors in the effects of YQA31...
December 2017: Pharmacological Reports: PR
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