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https://www.readbyqxmd.com/read/28630404/activation-of-d1r-pka-mtor-signaling-cascade-in-medial-prefrontal-cortex-underlying-the-antidepressant-effects-of-l-spd
#1
Bing Zhang, Fei Guo, Yuqin Ma, Yingcai Song, Rong Lin, Fu-Yi Shen, Guo-Zhang Jin, Yang Li, Zhi-Qiang Liu
Major depressive disorder (MDD) is a common neuropsychiatric disorder characterized by diverse symptoms. Although several antidepressants can influence dopamine system in the medial prefrontal cortex (mPFC), but the role of D1R or D2R subtypes of dopamine receptor during anti-depression process is still vague in PFC region. To address this question, we investigate the antidepressant effect of levo-stepholidine (l-SPD), an antipsychotic medication with unique pharmacological profile of D1R agonism and D2R antagonism, and clarified its molecular mechanisms in the mPFC...
June 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28606822/genistein-a-dietary-soy-isoflavone-exerts-antidepressant-like-effects-in-mice-involvement-of-serotonergic-system
#2
Pei Hu, Li Ma, Yan-Gui Wang, Feng Ye, Chuang Wang, Wen-Hua Zhou, Xin Zhao
Genistein, a principal isoflavone property of soybeans, possesses multiple pharmacological activities such as neuroprotection. Recently, it was reported that genistein exerted antidepressant-like effects in animal models, but the mechanism of action remains ambiguous. The purpose of this study was to investigate the antidepressant-like effect of genistein in mice and explore the underlying mechanism(s), using two mouse models of depression, i.e. forced swim test (FST) and tail suspension test (TST). Chronic, but not acute (single dose), genistein treatment (5, 15 or 45 mg/kg, p...
June 9, 2017: Neurochemistry International
https://www.readbyqxmd.com/read/28601589/sharpsports-mental-health-awareness-research-project-prevalence-and-risk-factors-of-depressive-symptoms-and-life-stress-in-elite-athletes
#3
Sarah Beable, Mark Fulcher, Arier C Lee, Bruce Hamilton
OBJECTIVES: Our study aims to estimate the prevalence of symptoms of depression and daily life hassles in elite athletes. DESIGN: A cross-sectional prospective epidemiological study design. METHODS: An online anonymous survey was administered during a 2-month period from May to July 2015. Athletes 18 years of age (or older) who were members of the High Performance Sport New Zealand programme were invited to participate. Of 370 potential participants, 187 completed responses were received (51%)...
May 17, 2017: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/28585192/rsk2-knockout-affects-emotional-behavior-in-the-intellicage
#4
Matthias Fischer, Victoria Cabello, Sandy Popp, Sven Krackow, Leif Hommers, Jürgen Deckert, Klaus-Peter Lesch, Angelika G Schmitt-Böhrer
Ribosomal s6 kinase 2 is a growth factor activated serine/threonine kinase and member of the ERK signaling pathway. Mutations in the Rsk2 gene cause Coffin-Lowry syndrome, a rare syndromic form of intellectual disability. The Rsk2 KO mouse model was shown to have learning and memory defects. We focused on the investigation of the emotional behavioral phenotype of Rsk2 KO mice mainly in the IntelliCage. They exhibited an anti-depressive, sucrose reward seeking phenotype and showed reduced anxiety. Spontaneous activity was increased in some conventional tests...
June 6, 2017: Behavior Genetics
https://www.readbyqxmd.com/read/28579928/single-cell-amperometry-reveals-curcuminoids-modulate-the-release-of-neurotransmitters-during-exocytosis-from-pc12-cells
#5
Xianchan Li, Amir Saeid Mohammadi, Andrew G Ewing
We used single cell amperometry to examine whether curcumin and bisdemethoxycurcumin (BDMC), substances that are suggested to affect learning and memory, can modulate monoamine release from PC12 cells. Our results indicate both curcumin and BDMC need long-term treatment (72 h in this study) to influence exocytosis effectively. By analyzing the parameters calculated from single exocytosis events, it can be concluded that curcumin and BDMC affect exocytosis through different mechanisms. Curcumin accelerates the event dynamics with no significant change of the monoamine amount released from single exocytotic events, whereas BDMC attenuates the amount from single exocytotic event with no significant change of the event dynamics...
November 15, 2016: Journal of Electroanalytical Chemistry
https://www.readbyqxmd.com/read/28554064/driving-under-the-influence-of-drugs-perceptions-and-attitudes-of-new-zealand-drivers
#6
Neha Malhotra, Nicola J Starkey, Samuel G Charlton
This study explored the patterns of drug driving in New Zealand by investigating 1) drivers' perceptions about impairment caused by legal and illegal drugs 2) countermeasures employed by drivers when under the influence of drugs (e.g., decisions not to drive) 3) drivers' attitudes about police enforcement of drug driving and 4) the factors that predict the likelihood of engaging in drug driving. Participants (n=434) were licensed drivers who completed an online questionnaire. Results of the questionnaire indicated that drivers rated hallucinogens and opiates as being the illegal drugs producing the highest level of driving impairment and cannabis the lowest...
May 26, 2017: Accident; Analysis and Prevention
https://www.readbyqxmd.com/read/28538206/spectroscopic-far-or-terahertz-mid-infrared-and-raman-investigation-thermal-analysis-and-biological-activity-of-piplartine
#7
Anubha Srivastava, T Karthick, B D Joshi, Rashmi Mishra, Poonam Tandon, A P Ayala, Javier Ellena
Research in the field of medicinal plants including Piper species like long pepper (Piper longum L.- Piperaceae) is increasing all over the world due to its use in traditional and Ayurvedic medicine. Piplartine (piperlongumine, 5,6-dihydro-1-[(2E)-1-oxo-3-(3,4,5-trimethoxyphenyl)-2-propenyl]-2(1H)-pyridinone), a biologically active alkaloid/amide was isolated from the phytochemical investigations of Piper species, as long pepper. This alkaloid has cytotoxic, anti-fungal, anti-diabetic, anti-platelet aggregation, anti-tumoral, anxiolytic, anti-depressant, anti-leishmanial, and genotoxic activities, but, its anticancer property is the most promising and has been widely explored...
May 5, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28503523/treadmill-exercise-ameliorates-depressive-symptoms-through-increasing-serotonin-expression-in-postpartum-depression-rats
#8
Eun-Sang Ji, Jae-Min Lee, Tae-Woon Kim, You-Mi Kim, Yeon-Soo Kim, Kijeong Kim
Postpartum depression (PPD) is defined as the depressive symptoms that occur from the moment of delivery until 12 months after delivery. PPD symptoms are closely associated with reduced activity of the serotonergic system. Serotonin (5-hydroxytryptamine, 5-HT) plays an important role in the pathogenesis of depression. Tryptophan hydroxylase (TPH) catalyzes the rate-limiting step of 5-HT biosynthesis in the serotonergic neurons. Exercise exerts anti-depressive effect on depression patients as well as on animal models of depression...
April 2017: Journal of Exercise Rehabilitation
https://www.readbyqxmd.com/read/28503402/physical-exercise-for-treatment-of-mood-disorders-a-critical-review
#9
C M Hearing, W C Chang, K L Szuhany, T Deckersbach, A A Nierenberg, L G Sylvia
PURPOSE OF THE REVIEW: The purpose of this review is to critically assess the evidence for exercise as an adjunct intervention for major depressive disorder and bipolar disorder, chronic conditions characterized by frequent comorbid conditions as well as interepisodic symptoms with poor quality of life and impaired functioning. Individuals with these mood disorders are at higher risk of cardiovascular disease and premature death in part because of increased rates of obesity, inactivity, and diabetes mellitus compared to the general population...
December 2016: Current Behavioral Neuroscience Reports
https://www.readbyqxmd.com/read/28501680/dilated-virchow-robin-spaces-in-the-hippocampus-impact-behaviors-and-effects-of-anti-depressant-treatment-in-model-of-depressed-rats
#10
Yuefeng Li, Jinchuan Yan, Xiaolan Zhu, Yan Zhu, Shun Yao, Yuhao Xu, Shenghong Ju
The occurrences of dilated Virchow-Robin spaces (dVRSs) and inflammatory factors were closely related with development of depression and antidepressants. The present study indicated accumulation of inflammatory factors in dVRSs played a practical role in behaviors and the treatment-resistant in rats with depression. Eighty-one male Wistar rats were exposed to chronic unpredictable mild stress (CUMS) until the model was successfully established. According to the detection of dVRSs on 7 T structural magnetic resonance imaging (MRI), rats were divided into two groups (45 CUMS(non-dVRSs) rats and 36 CUMS(dVRSs) rats)...
April 21, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28499312/evidence-for-the-involvement-of-monoaminergic-pathways-in-the-antidepressant-like-activity-of-cymbopogon-citratus-in-mice
#11
Solomon Umukoro, Somtochukwu I Ogboh, Osarume Omorogbe, Abdul-Lateef A Adekeye, Matthew O Olatunde
Objectives Depression is a complex neuropsychiatric disorder, which affects the quality of life of the sufferers and treatment approach is associated with serious adverse effects and sometimes therapeutic failures. Cymbopogon citratus leaf (CC) has been reported to exert anti-depressant effect but its mechanism of action is yet to be elucidated hence, the need for this study. Methods The anti-depressant-like effect of Cymbopogon citratus aqueous leaf was evaluated using forced swim test (FST), tail suspension test (TST) and yohimbine-induced lethality test (YLT) in aggregated mice...
May 12, 2017: Drug Research
https://www.readbyqxmd.com/read/28482013/hydrogen-sulfide-inhibits-chronic-unpredictable-mild-stress-induced-depressive-like-behavior-by-upregulation-of-sirt-1-involvement-in-suppression-of-hippocampal-endoplasmic-reticulum-stress
#12
Shu-Yun Liu, Dan Li, Hai-Ying Zeng, Li-Yuan Kan, Wei Zou, Ping Zhang, Hong-Feng Gu, Xiao-Qing Tang
Background: Hydrogen sulfide (H2S) is a crucial signaling molecule with a wide range of physiological functions. Previously, we have confirmed that stress-induced depression is accompanied with disturbance of H2S generation in hippocampus. The present work attempted to investigate the inhibitory effect of H2S on chronic unpredictable mild stress (CUMS)-induced depressive-like behaviors and the underlying mechanism. Methods: We established the rat model of CUMS to simulate depression...
May 6, 2017: International Journal of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28469194/kai-xin-san-series-formulae-alleviate-depressive-like-behaviors-on-chronic-mild-stressed-mice-via-regulating-neurotrophic-factor-system-on-hippocampus
#13
Yue Zhu, Cheng Chao, Xiuzhu Duan, Xiaoxuan Cheng, Pei Liu, Shulan Su, Jinao Duan, Tina Tingxia Dong, Karl Wah-Keung Tsim
Kai-xin-san (KXS) is a famous Chinese medicinal formula applied for treating stress-related psychiatric diseases with the symptoms such as depression, forgetfulness and dizziness. In clinic, the composition ratio of KXS is always varied and KXS series formulae are created. Here, we aim to compare the anti-depressive effect of different ratios of KXS and reveal its action mechanism on regulation of neurotrophic factor system. Firstly, daily intra-gastric administration of chemically standardized extracts of KXS series formulae for seven days significantly alleviated the depressive symptoms of chronic unpredictable mild stressed mice displayed by enhanced sucrose consumptions and decreased immobile time of forced swimming coupled with increased locomotor activities...
May 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28461003/ginsenoside-rg3-exerts-anti-depressive-effect-on-an-nmda-treated-cell-model-and-a-chronic-mild-stress-animal-model
#14
Hualin Zhang, Zhongliu Zhou, Ziming Chen, Zhiyong Zhong, Zhong Li
Depression is a common mental disorder and a leading cause of disability. At its most severe, it can lead to suicide. Recently, there has been growing interest in the application of natural herbs for the prevention and treatment of depression. In this report, we found that the ginsenoside active component Rg3 has an apparent antidepressant effect. In N-methyl-d-aspartic acid (NMDA)-treated HT22 murine hippocampal neuronal cells, Rg3 recovered proliferation and inhibited apoptosis by altering the cell cycle...
May 2017: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/28460354/suppression-of-pro-inflammatory-cytokine-expression-and-lack-of-anti-depressant-like-effect-of-fluoxetine-in-lipopolysaccharide-treated-old-female-mice
#15
Weronika Duda, Marta Kubera, Grzegorz Kreiner, Katarzyna Curzytek, Jan Detka, Katarzyna Głombik, Joanna Ślusarczyk, Agnieszka Basta-Kaim, Bogusława Budziszewska, Władysław Lasoń, Magdalena Regulska, Monika Leśkiewicz, Adam Roman, Agnieszka Zelek-Molik, Irena Nalepa
Some antidepressants show a significantly lower efficacy in elderly patients, particularly in women. Previous studies have shown that antidepressants administered to young animals reduced depression-like symptoms induced by lipopolysaccharide (LPS). The aim of this study was to find out whether the antidepressant and anti-inflammatory properties of fluoxetine (FLU) can be observed also in old female C57BL/6J mice. A depression-like state was evoked by the administration of LPS (100μg/kg for 4 consecutive days) which was followed by reduction of sucrose preference (anhedonia) and enhancement of immobility-time in the forced swim test (FST)...
April 28, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28454575/ziziphi-spinosae-lily-powder-suspension-in-the-treatment-of-depression-like-behaviors-in-rats
#16
Yifang Wang, Mei Huang, Xinyi Lu, Runze Wei, Jinyong Xu
BACKGROUND: Depression is a chronic, recurring and potentially life-threatening illness. Current treatments for depression are characterized by a low success rate and associated with a wide variety of side effects. The aim of the present study was to evaluate the behavioral anti-depressant effect of a novel herbal compounds named ziziphi spinosae lily powder suspension, as well as to investigate its potential mechanisms. METHODS: Except for body weight, depressive-like behaviors were also evaluated using forced swimming test, sucrose consumption test and open field test...
April 28, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28453490/plasma-amyloid-%C3%AE-and-alzheimer-s-disease-related-changes-in-late-life-depression
#17
Chiemi Yamazaki, Toshio Tamaoki, Akihiko Nunomura, Kenichi Tamai, Kazuyuki Yasuda, Nobutaka Motohashi
To elucidate an involvement of amyloid dysmetabolism in the pathophysiology of depression, we investigated associations of plasma amyloid-β (Aβ) levels with Alzheimer's disease-related changes in neuroimaging and cognitive dysfunction in patients with late-life depression. Higher plasma Aβ40, but not Aβ42 nor Aβ40/Aβ42 ratio, was associated with higher degree of parahippocampal atrophy and lower verbal fluency performance. Indeed, high plasma Aβ40 predicted poor cognitive prognosis of depressed patients with mild cognitive impairment...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28450222/probiotic-treatment-protects-against-the-pro-depressant-like-effect-of-high-fat-diet-in-flinders-sensitive-line-rats
#18
Anders Abildgaard, Betina Elfving, Marianne Hokland, Sten Lund, Gregers Wegener
Major depressive disorder (MDD) is highly associated with dysmetabolic conditions, such as obesity and diabetes mellitus type 2, and the gut microbiota may interact with both disease entities. We have previously shown that a high-fat diet (HFD) exacerbated depressive-like behaviour uniquely in Flinders Sensitive Line (FSL) rats that inherently present with an increased level of depressive-like behaviour compared with Flinders Resistant Line (FRL) rats. We therefore investigated whether multispecies probiotics possessed anti-depressant-like effect in FSL rats or protected against the pro-depressant-like effect of HFD...
April 24, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28446829/experimental-evaluation-of-hi%C3%A1-gv%C3%A4-di-gh%C3%A1-ta-in-behavioral-despair-using-animal-models
#19
Poonam Ashish Gupte, Jayshree Dawane, Asmita Ashish Wele
CONTEXT: Depression, a sustained mood disorder caused by selective diminution of specialized cells in brain is increasing at an alarming rate. It will be the second largest morbid illness by next decade and is the leading cause of suicidal deaths. The available antidepressant medications benefit only a third of its recipients and have many side effects. Hence, it is imperative to search in Ayurveda for leads. AIM: To evaluate Anti- depressant activity of Hiṅgvādi Ghṛta in vivo ...
October 2016: Ancient Science of Life
https://www.readbyqxmd.com/read/28438149/anti-depressant-and-anxiolytic-potential-of-acacia-hydaspica-r-parker-aerial-parts-extract-modulation-of-brain-antioxidant-enzyme-status
#20
Tayyaba Afsar, Suhail Razak, Muhammad Rashid Khan, Ali Almajwal
BACKGROUND: Oxidative stress may link to psychiatric disorders, and is being regarded as a plausible mechanism that can affect the regulation of these illnesses. The present study was undertaken to investigate the antidepressant and anxiolytic potential of A. hydaspica R. parkers. Brain oxidative stress enzyme levels were analyzed to correlate depression and stress with brain antioxidant status. METHODS: Antidepressant and anxiolytic effect of methanol extract of A...
April 24, 2017: BMC Complementary and Alternative Medicine
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