Minako Takagi, Shin Ono, Tatsuro Kumaki, Naoto Nishimura, Hiroaki Murakami, Yumi Enomoto, Takuya Naruto, Hideaki Ueda, Kenji Kurosawa
Pathogenic AGO1 variants have been associated with neurodevelopmental disorders, including autism spectrum disorder, developmental delay, intellectual disability, and dysmorphic facial appearance. In mammalian models, defects in microRNA (miRNA) biogenesis are associated with congenital heart disease and dilated cardiomyopathy. We describe the case of a patient with partial anomalous pulmonary venous return, hypoplastic left lung, bilateral pulmonary sequestration, and dilated myocardiopathy. We identified a de novo pathogenic variant of AGO1, which encodes an Argonaute protein forming a gene-silencing complex with microRNAs...
December 23, 2022: American Journal of Medical Genetics. Part A