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https://www.readbyqxmd.com/read/28526874/radiopaque-resorbable-inferior-vena-cava-filter-infused-with-gold-nanoparticles
#1
Li Tian, Patrick Lee, Burapol Singhana, Aaron Chen, Yang Qiao, Linfeng Lu, Jonathan O Martinez, Ennio Tasciotti, Adam Melancon, Steven Huang, Mitch Eggers, Marites P Melancon
Failure to remove a retrievable inferior vena cava (IVC) filter can cause severe complications with high treatment costs. Polydioxanone (PPDO) has been shown to be a good candidate material for resorbable IVC filters. However, PPDO is radioluscent under conventional imaging modalities. Thus, the positioning and integrity of these PPDO filters cannot be monitored by computed tomography (CT) or x-ray. Here we report the development of radiopaque PPDO IVC filters based on gold nanoparticles (AuNPs). Commercially available PPDO sutures were infused with AuNPs...
May 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28526627/dynamic-fatigue-measurement-of-human-erythrocytes-using-dielectrophoresis
#2
Yuhao Qiang, Jia Liu, E Du
Erythrocytes must undergo severe deformation to pass through narrow capillaries and submicronic splenic slits for several hundred thousand times in their normal lifespan. Studies of erythrocyte biomechanics have been mainly focused on cell deformability and rheology measured from a single application of stress and mostly under a static or quasi-static state using classical biomechanical techniques, such as optical tweezers and micropipette aspiration. Dynamic behavior of erythrocytes in response to cyclic stresses that contributes to the membrane failure in blood circulation is not fully understood...
May 16, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28524066/a-flight-phase-terrain-following-control-strategy-for-stable-and-robust-hopping-of-a-one-legged-robot-under-large-terrain-variations
#3
Natan Shemer, Amir Degani
This work demonstrates a simple, once per step, flight-phase control method for robots running on a planar unknown rough-terrain environment. The robot used to exemplify these control strategies is the ParkourBot, a Spring-Loaded Inverted Pendulum (SLIP)-based robot. The SLIP model is widely used for the description of humans and animals running motion and has been the basis for many robots. A known control scheme for increasing robustness of the conservative, SLIP model is the Swing Leg Retraction (SLR) method...
May 19, 2017: Bioinspiration & Biomimetics
https://www.readbyqxmd.com/read/28523364/-structured-patient-handovers-in-perioperative-medicine-rationale-and-implementation-in-clinical-practice
#4
M J Merkel, V von Dossow, B Zwißler
Clear and consistent communication is pivotal for well-functioning teamwork, in operating theatres as well as intensive care units. However, patient handovers significantly vary between specialties and locations. If communication is not well structured, it might increase the risk for mishaps and malpractice. Therefore, implementing structured handover protocols is pivotal. The perioperative setting is a high-risk environment that is prone to communication failures due to operational design (frequent change of shift due to working time restrictions) and a high work load and multitasking (operating room management, short surgery times, concurrent emergencies)...
May 18, 2017: Der Anaesthesist
https://www.readbyqxmd.com/read/28522238/biomechanical-comparison-of-four-coupled-fixation-systems-for-acl-reconstruction-with-bone-socket-or-full-tunnel-on-the-tibial-side
#5
Edoardo Monaco, Mattia Fabbri, Riccardo Maria Lanzetti, Andrea Del Duca, Luca Labianca, Andrea Ferretti
BACKGROUND: To compare in an animal model the biomechanical properties of four coupled fixation devices currently used in ACL reconstruction. Three out of four devices used a full tibial tunnel with an interference screw, while the other one system used a tibial socket and an adjustable loop suspension device. The null hypothesis is that there are no biomechanical differences between all the techniques tested. METHODS: Thirty two femur-graft-tibia complexes were mounted on a tensile machine using bovine digital extensor tendons, porcine knees and four different fixation device combinations: After a preconditioning with a tensile load of 90N for five minutes, 1000cycles between 0 and 150N were applied to the complex before the final pulled to failure...
May 15, 2017: Knee
https://www.readbyqxmd.com/read/28521719/virological-suppression-and-patterns-of-resistance-amongst-patients-on-antiretroviral-therapy-at-4-nigerian-military-hospitals
#6
Keshinro Babajide, Ayemoba Ojor, Terfa Kene, Ake Julie, Crowell Trevor A, Adamu Yakubu, Mohammed Tahir, Okoye Ifeanyi, Odeyemi Sunday, Crawford Keith, Hughes Lindsay, Akintunde Ezekiel, Umar Tahir, Hamm Tiffany E, Njoku Ogbonnaya S
BACKGROUND: In resource-constrained settings, plasma HIV-1 RNA quantification has not been routinely available for the monitoring of response to antiretroviral therapy. This study evaluated virological suppression rates amongst patients on first-line ART in four Nigerian military hospitals. METHODS: We conducted a cross-sectional study of 325 randomly selected adult clinic clients (≥18 years old) on first-line ART regimens at four Nigerian military hospitals. Plasma HIV-1 RNA was assayed using a Roche COBAS TaqMan48 with High Pure System...
May 16, 2017: Current HIV Research
https://www.readbyqxmd.com/read/28520618/defining-a-cut-off-for-atazanavir-in-hair-samples-associated-with-virological-failure-among-adolescents-failing-second-line-antiretroviral-treatment
#7
Tariro Dianah Chawana, Monica Gandhi, Kusum Nathoo, Bernard Ngara, Alexander Louie, Howard Horng, David Katzenstein, John Metcalfe, Charles Fungai Brian Nhachi
BACKGROUND: Adequate antiretroviral exposure is crucial for virological suppression. We assessed the relationship between atazanavir hair levels with self-reported adherence, virological outcomes, and the effect of a home-based adherence intervention in HIV-infected adolescents failing 2-line antiretroviral treatment in Zimbabwe. METHODS: HIV-infected adolescents on atazanavir/ritonavir-based 2-line treatment for ≥6 months with viral load (VL) >1,000 copies/ml were randomised to either standard care (control) or standard care plus modified directly administered antiretroviral therapy (mDAART) (intervention)...
May 17, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28520458/anchored-transosseous-equivalent-versus-anchorless-transosseous-rotator-cuff-repair-a-biomechanical-analysis-in-a-cadaveric-model
#8
Kelly G Kilcoyne, Stanley G Guillaume, Catherine V Hannan, Evan R Langdale, Stephen M Belkoff, Uma Srikumaran
BACKGROUND: The original approach for the repair of torn rotator cuffs involved an open technique with sutures passing through the greater tuberosity and tendon. The development of suture anchors allowed for an all-arthroscopic approach with anchor configurations attempting to re-create a transosseous fixation pattern. Presently, an arthroscopic approach can be combined with a transosseous suture configuration without using anchors. PURPOSE: To evaluate cyclic loading, ultimate load to failure, and the failure mechanisms of transosseous-equivalent (TOE) repair with anchors and anchorless transosseous (AT) repair of rotator cuff tears...
May 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28515495/the-failure-envelope-concept-applied-to-the-bone-dental-implant-system
#9
R Korabi, K Shemtov-Yona, A Dorogoy, D Rittel
Dental implants interact with the jawbone through their common interface. While the implant is an inert structure, the jawbone is a living one that reacts to mechanical stimuli. Setting aside mechanical failure considerations of the implant, the bone is the main component to be addressed. With most failure criteria being expressed in terms of stress or strain values, their fulfillment can mean structural flow or fracture. However, in addition to those effects, the bony structure is likely to react biologically to the applied loads by dissolution or remodeling, so that additional (strain-based) criteria must be taken into account...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28512702/an-intracardiac-soft-robotic-device-for-augmentation-of-blood-ejection-from-the-failing-right-ventricle
#10
Markus A Horvath, Isaac Wamala, Eric Rytkin, Elizabeth Doyle, Christopher J Payne, Thomas Thalhofer, Ignacio Berra, Anna Solovyeva, Mossab Saeed, Sara Hendren, Ellen T Roche, Pedro J Del Nido, Conor J Walsh, Nikolay V Vasilyev
We introduce an implantable intracardiac soft robotic right ventricular ejection device (RVED) for dynamic approximation of the right ventricular (RV) free wall and the interventricular septum (IVS) in synchrony with the cardiac cycle to augment blood ejection in right heart failure (RHF). The RVED is designed for safe and effective intracardiac operation and consists of an anchoring system deployed across the IVS, an RV free wall anchor, and a pneumatic artificial muscle linear actuator that spans the RV chamber between the two anchors...
May 16, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28512551/consensus-statements-and-clinical-recommendations-on-treatment-indications-surgical-procedures-prosthetic-protocols-and-complications-following-all-on-4-standard-treatment-9th-mozo-grau-ticare-conference-in-quintanilla-spain
#11
REVIEW
Miguel Penarrocha-Diago, María Penarrocha-Diago, Regino Zaragozí-Alonso, David Soto-Penaloza, Meeting On Behalf Of The Ticare Consensus
OBJECTIVES: The present consensus report critically evaluates the scientific evidence based on a comprehensive systematic review of the All-On-4 treatment concept, focusing primarily on the treatment indications, surgical procedures and prosthetic protocols, and secondarily on the mechanical and biological complications involved. MATERIAL AND METHODS: A systematic review was made in advance of the meeting. Consensus statements, treatment guidelines and recommendations for future research were based on within-group as well as plenary debates and discussions of the systematic review...
May 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28511967/a-sliding-hip-screw-augmented-with-2-screws-is-biomechanically-similar-to-an-inverted-triad-of-cannulated-screws-in-repair-of-a-pauwels-type-iii-fracture
#12
B Kemker, K Magone, J Owen, P Atkinson, S Martin, T Atkinson
OBJECTIVE: Pauwels III femoral neck fractures are highly unstable. These fractures are commonly treated with three cannulated screws or sliding hip screw (SHS) implants, however high rates of non-union persist. A hybrid SHS construct has recently been proposed. The objective of the study was to compare this construct to the familiar inverted triad of cannulated screws and to a single SHS. METHODS: Fourth generation biomechanical femur analogs were used to create a highly repeatable injury model...
May 8, 2017: Injury
https://www.readbyqxmd.com/read/28511594/fixation-strength-in-full-and-limited-fixation-of-osteoporotic-distal-radius-fractures
#13
P Kaveh Mansuripur, Joseph A Gil, Dale Cassidy, Patrick Kane, Augusta Kluk, Joseph J Crisco, Edward Akelman
BACKGROUND: The purpose of this investigation is to determine whether osteoporotic intra-articular distal radius fractures surgically treated by filling all 7 distal screws of a volar plate will have a higher load to failure than those treated by filling only 4 distal screws. METHODS: Ten matched pairs of fresh frozen cadaveric forearms were randomized within each pair to be treated by using either all 7 of the distal holes of a volar plate or only 4 distal screws...
May 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28506630/cost-effective-hiv-1-virological-monitoring-in-resource-limited-settings-using-a-modified-commercially-available-qpcr-rna-assay
#14
Jayaseelan Boobalan, Andrea Torti, Thongadi Ramesh Dinesha, Sunil Suhas Solomon, Pachamuthu Balakrishnan, Shanmugam Saravanan
Virological monitoring through plasma viral load (PVL) quantification is essential for clinical management of HIV patients undergoing antiretroviral treatment (ART), and for detecting treatment failure. Quantitative PCR (qPCR)-based tests are the gold standard for measuring PVL. Largely because of their high cost, however, implementation of these tests in low- and middle-income countries fails to cover the testing demand. In this study, we aimed at reducing the running cost of the commercially available Abbott RealTime™ HIV-1 assay by minimizing the reagent consumption...
May 12, 2017: Journal of Virological Methods
https://www.readbyqxmd.com/read/28506489/enhancement-of-rotator-cuff-tendon-bone-healing-with-fibroblast-growth-factor-2-impregnated-in-gelatin-hydrogel-sheets-in-a-rabbit-model
#15
Takuya Tokunaga, Tatsuki Karasugi, Hitoshi Arimura, Ryuji Yonemitsu, Hidetoshi Sakamoto, Junji Ide, Hiroshi Mizuta
BACKGROUND: Application of fibroblast growth factor 2 (FGF-2) may improve the healing response after rotator cuff (RC) surgical repair. This study aimed to determine whether FGF-2-impregnated gelatin hydrogel sheet (GHS) incorporation into the bony trough on the greater tuberosity facilitates healing after RC surgical repair in rabbits. METHODS: We assigned 120 adult male Japanese white rabbits treated with unilateral surgery for supraspinatus tendon repair into the following groups: suture-only group (suture); suture and GHS with phosphate-buffered saline (carrier); suture and GHS with 3 µg of FGF-2 (F3); and suture and GHS with 30 µg of FGF-2 (F30)...
May 11, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28505850/damage-cluster-distributions-in-numerical-concrete-at-the-mesoscale
#16
Okan Yılmaz, Peter Michael Derlet, Jean-François Molinari
We investigate the size distribution of damage clusters in concrete under uniaxial tension loading conditions. Using the finite-element method, the concrete is modeled at the mesoscale by a random distribution of elastic spherical aggregates within an elastic mortar paste. The propagation and coalescence of damage zones are then simulated by means of dynamically inserted cohesive elements. Dynamic failure analysis shows that the size distribution of damage clusters follows a power law when a system-spanning cluster is first observed, with an exponent close to that of percolation theory...
April 2017: Physical Review. E
https://www.readbyqxmd.com/read/28504991/tablet-e-logbooks-four-thousand-clinical-cases-and-complications-e-logged-by-14-nondoctor-anesthesia-providers-in-nepal
#17
Shristi Shah, Oliver Ross, Stephen Pickering, Stephen Knoble, Indra Rai
BACKGROUND: To meet the need for essential surgery across rural Nepal, anesthesia at district level is delivered by nondoctor anesthetists. They require support to maintain confidence and competence, and upgraded professional registration to secure their status. To meet these needs, a distance-blended learning course was pioneered and delivered. A core course requirement was to log all clinical cases; these were logged on a new e-logbook. METHODS: Fourteen nondoctor anesthesia providers working in 12 different districts across Nepal were enrolled in the 1-year course...
May 11, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28504263/dehydration-driven-stress-transfer-triggers-intermediate-depth-earthquakes
#18
Thomas P Ferrand, Nadège Hilairet, Sarah Incel, Damien Deldicque, Loïc Labrousse, Julien Gasc, Joerg Renner, Yanbin Wang, Harry W Green Ii, Alexandre Schubnel
Intermediate-depth earthquakes (30-300 km) have been extensively documented within subducting oceanic slabs, but their mechanics remains enigmatic. Here we decipher the mechanism of these earthquakes by performing deformation experiments on dehydrating serpentinized peridotites (synthetic antigorite-olivine aggregates, minerals representative of subduction zones lithologies) at upper mantle conditions. At a pressure of 1.1 gigapascals, dehydration of deforming samples containing only 5 vol% of antigorite suffices to trigger acoustic emissions, a laboratory-scale analogue of earthquakes...
May 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28502885/contra-lateral-bone-loss-at-the-distal-radius-in-postmenopausal-women-after-a-distal-radius-fracture-a-two-year-follow-up-hrpqct-study
#19
Joost J A de Jong, Jacobus J C Arts, Paul C Willems, Sandrine P G Bours, Judith P A Bons, Paul P C A Menheere, Bert van Rietbergen, Piet P Geusens, Joop P W van den Bergh
Opposite to the fracture side, bone mineral density (BMD) measured by DXA at the contra-lateral side does not change after a distal radius fracture. However, it is unknown if also bone micro-architecture and strength at the contralateral side are unaffected. Therefore, the aim of this study was to assess BMD, micro-architecture and bone mechanical properties at the contra-lateral side during two years follow-up after a distal radius fracture using high resolution peripheral quantitative computed tomography (HRpQCT)...
May 11, 2017: Bone
https://www.readbyqxmd.com/read/28502331/risk-factors-and-outcomes-of-acute-kidney-injury-in-patients-with-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#20
Wei Yuan, Yu-Yi Zhang, Zheng-Guo Zhang, Ying Zou, Hong-Zhou Lu, Zhi-Ping Qian
BACKGROUND: Acute kidney injury (AKI) is common in patients with hepatitis B virus (HBV)-related acute-on-chronic liver failure (ACLF); however, few studies concerning the risk factors and recovery patterns of renal function have been published. MATERIALS AND METHODS: A retrospective analysis of 150 patients with HBV-ACLF was performed. The occurrence, risk factors and functional recovery of AKI among patients with HBV-ACLF were investigated. RESULTS: A total of 90 patients (60%) with HBV-ACLF developed AKI...
May 2017: American Journal of the Medical Sciences
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