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https://www.readbyqxmd.com/read/28725322/recurrent-body-rash-warranted-second-desensitization-with-acyclovir-in-a-myeloma-patient-a-case-report
#1
Jack T Seki, Pamela Ng, Wallace Lam, Julie Cote, Anca Prica
A 75-year-old woman developed a moderately severe rash about a week and a half after the start of bortezomib (Btb)-based chemotherapy for IgG lambda multiple myeloma; at the time, she was also receiving acyclovir as antiviral prophylaxis in addition to herpes zoster (HZ) vaccination. HZ reactivation rate is high in Btb recipients; therefore, the timing of antiviral prevention is critical in relation to Btb. Attempts were made to identify the offending agent based on the timing of drugs administered and the appearance of skin lesions in relation to other drugs...
August 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28707438/long-term-impact-of-the-endocrine-disruptor-tributyltin-on-male-fertility-following-a-single-acute-exposure
#2
Sumonto Mitra, Ankit Srivastava, Shashi Khandelwal
Declining rate of human fertility is a growing concern, where lifestyle and environmental factors play an important role. We recently demonstrated that tributyltin (TBT), an omnipresent endocrine disruptor, affects testicular cells in vitro. In this study, male Wistar rats were gavaged a single dose of 10, 20, and 30 mg/kg TBT-chloride (TBTC) (to mimic accidental exposure in vivo) and sacrificed on day 3 and day 7, respectively. TBT bioavailability was evaluated by estimating total tin content, and essential metal levels were analyzed along with redox molecules (ROS and GSH/GSSG) to understand the effect on physiological conditions...
July 14, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28706839/suspensory-fixation-device-for-use-with-bone-patellar-tendon-bone-grafts
#3
Philippe Colombet, Nicolas Bouguennec
Good to excellent results at long-term follow-up have been published for bone-patellar tendon-bone (BTB) graft anterior cruciate ligament reconstruction. Fixation using screws historically has been the most common choice for femoral and tibial bone blocks, but screws present several disadvantages, which include the risk of blowout (for which prevention implies having to shift the position of the tunnel anteriorly), as well as lesions of the bone blocks and tendons. This article describes a technique using Pullup BTB adjustable-loop length suspensory fixation (SBM, Lourdes, France) on the femoral and tibial sides...
June 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28704479/dynamic-changes-in-bach1-expression-in-the-kidney-of-rhabdomyolysis-associated-acute-kidney-injury
#4
Masakazu Yamaoka, Hiroko Shimizu, Toru Takahashi, Emiko Omori, Hiroshi Morimatsu
Free heme, a pro-oxidant released from myoglobin, is thought to contribute to the pathogenesis of rhabdomyolysis-associated acute kidney injury (RM-AKI), because renal overexpression of heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, confers protection against RM-AKI. BTB and CNC homology 1 (Bach1) is a heme-responsive transcription factor that represses HO-1. Here, we examined the changes with time in the gene expression of Bach1, HO-1, and δ-aminolevulinate synthase (ALAS1, a heme biosynthetic enzyme) in the rat kidney using an RM-AKI model induced by the injection of 50% glycerol (10 mL/kg body weight) into bilateral limbs...
2017: PloS One
https://www.readbyqxmd.com/read/28701916/the-role-of-hotair-mir-148b-3p-usf1-on-regulating-the-permeability-of-btb
#5
Libo Sa, Yan Li, Lini Zhao, Yunhui Liu, Ping Wang, Libo Liu, Zhen Li, Jun Ma, Heng Cai, Yixue Xue
Homeobox transcript antisense intergenic RNA (HOTAIR), as a long non-coding RNA (lncRNA), has been considered to play critical roles in the biological properties of various tumors. The purposes of this study were to investigate the role and possible molecular mechanisms of HOTAIR in regulating the permeability of blood tumor barrier (BTB) in vitro. Our present study elucidated that the expressions of HOTAIR and upstream stimulatory factor 1 (USF1) was up-regulated, but miR-148b-3p was down-regulated in glioma microvascular endothelial cells (GECs)...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28701473/zbtb7a-induction-in-alveolar-macrophages-is-implicated-in-anti-hla-mediated-lung-allograft-rejection
#6
Deepak K Nayak, Fangyu Zhou, Min Xu, Jing Huang, Moriya Tsuji, Jinsheng Yu, Ramsey Hachem, Andrew E Gelman, Ross M Bremner, Michael A Smith, Thalachallour Mohanakumar
Chronic rejection significantly limits long-term success of solid organ transplantation. De novo donor-specific antibodies (DSAs) to mismatched donor human leukocyte antigen after human lung transplantation predispose lung grafts to chronic rejection. We sought to delineate mediators and mechanisms of DSA pathogenesis and to define early inflammatory events that trigger chronic rejection in lung transplant recipients and obliterative airway disease, a correlate of human chronic rejection, in mouse. Induction of transcription factor zinc finger and BTB domain containing protein 7a (Zbtb7a) was an early response critical in the DSA-induced chronic rejection...
July 12, 2017: Science Translational Medicine
https://www.readbyqxmd.com/read/28690461/hospital-for-special-surgery-acl-registry-2-year-outcomes-suggest-low-revision-and-return-to-or-rates
#7
Moira McCarthy, Katherine Mallett, Matthew Abola, Sherrie Vassallo, Joseph Nguyen
BACKGROUND: Anterior cruciate ligament (ACL) injuries are among the most common knee injuries. Patient outcomes, rate of subsequent operations, and rate of subsequent ACL reconstruction following primary ACL reconstruction need to be evaluated. QUESTIONS/PURPOSES: This study was designed to answer the following questions: (1) What is the return to surgery (OR) rate following primary ACL reconstruction and (2) what is the revision ACL reconstruction rate? METHODS: Data was drawn from the Hospital for Special Surgery (HSS) ACL Registry...
July 2017: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/28687044/dual-modified-liposome-codelivery-of-doxorubicin-and-vincristine-improve-targeting-and-therapeutic-efficacy-of-glioma
#8
Yue Zhang, Meifang Zhai, Zhijiang Chen, Xiaoyang Han, Fanglin Yu, Zhiping Li, Xiangyang Xie, Cuiyan Han, Lian Yu, Yang Yang, Xingguo Mei
Therapeutic outcome for the treatment of glioma was often limited due to drug resistance and low permeability of drug across the multiple physiological barriers, including the blood-brain barrier (BBB), and the blood-tumor barrier (BTB). In order to overcome these hurdles, we designed T7 and (D)A7R dual peptides-modified liposomes (abbreviated as T7/(D)A7R-LS) to efficiently co-delivery doxorubicin (DOX) and vincristine (VCR) to glioma in this study. T7 is a seven-peptide ligand of transferrin receptors (TfR) capable of circumventing the BBB and then targeting glioma...
November 2017: Drug Delivery
https://www.readbyqxmd.com/read/28685309/mir-155-enhances-phagocytic-activity-of-%C3%AE-thalassemia-hbe-monocytes-via-targeting-of-bach1
#9
Kanitta Srinoun, Chamnong Nopparatana, Malai Wongchanchailert, Suthat Fucharoen
Abnormal red blood cell (RBC) clearance in β-thalassemia is triggered by activated monocytes. Recent reports indicate that miRNA (miR-) plays a role in monocyte activation. To study phagocytic function, we co-cultured monocytes of normal, non-splenectomized and splenectomized β-thalassemia/HbE individuals with RBCs obtained from normal, non-splenectomized and splenectomized β-thalassemia/HbE individuals. The phagocytic activity of β-thalassemia/HbE monocytes co-cultured with β-thalassemia/HbE RBCs was significantly higher than that of normal monocytes co-cultured with normal RBCs...
July 6, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/28680043/molecular-epidemiology-of-mycobacterium-bovis-in-cameroon
#10
N F Egbe, A Muwonge, L Ndip, R F Kelly, M Sander, V Tanya, V Ngu Ngwa, I G Handel, A Novak, R Ngandalo, S Mazeri, K L Morgan, A Asuquo, B M de C Bronsvoort
We describe the largest molecular epidemiological study of Bovine Tuberculosis (bTB) in a sub-Saharan African country with higher spatial resolution providing new insights into bTB. Four hundred and ninety-nine samples were collected for culture from 201 and 179 cattle with and without bTB-like lesions respectively out of 2,346 cattle slaughtered at Bamenda, Ngaoundere, Garoua and Maroua abattoirs between 2012-2013. Two hundred and fifty-five M. bovis were isolated, identified and genotyped using deletion analysis, Hain® Genotype MTBC, spoligotyping and MIRU-VNTR...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28671497/use-of-whole-genome-sequencing-and-evaluation-of-the-apparent-sensitivity-and-specificity-of-antemortem-tuberculosis-tests-in-the-investigation-of-an-unusual-outbreak-of-mycobacterium-bovis-infection-in-a-michigan-dairy-herd
#11
Colleen S Bruning-Fann, Suelee Robbe-Austerman, John B Kaneene, Bruce V Thomsen, John D Tilden, Jean S Ray, Richard W Smith, Scott D Fitzgerald, Steven R Bolin, Daniel J O'Brien, Thomas P Mullaney, Tod P Stuber, James J Averill, David Marks
OBJECTIVE To describe use of whole-genome sequencing (WGS) and evaluate the apparent sensitivity and specificity of antemortem tuberculosis tests during investigation of an unusual outbreak of Mycobacterium bovis infection in a Michigan dairy herd. DESIGN Bovine tuberculosis (bTB) outbreak investigation. ANIMALS Cattle, cats, dog, and wildlife. PROCEDURES All cattle in the index dairy herd were screened for bTB with the caudal fold test (CFT), and cattle ≥ 6 months old were also screened with a γ-interferon (γIFN) assay...
July 15, 2017: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/28668939/selective-atp-hydrolysis-inhibition-in-f1fo-atp-synthase-enhances-radiosensitivity-in-non-small-cell-lung-cancer-cells-a549
#12
Yupei Wang, Qinzheng Hou, Guoqing Xiao, Shifeng Yang, Cuixia Di, Jing Si, Rong Zhou, Yancheng Ye, Yanshan Zhang, Hong Zhang
BACKGROUND: F1Fo-ATP synthase (F1Fo-ATPase) is a reversibly rotary molecular machine whose dual functions of synthesizing or hydrolyzing ATP switch upon the condition of cell physiology. The robust ATP-hydrolyzing activity occurs in ischemia for maintaining the transmembrane proton motive force of mitochondria inner membrane, but the effect of F1Fo-ATPase on X-ray response of non-small-cell lung cancer (NSCLC) cells is unknown. METHODS AND FINDINGS: We studied whether ATP hydrolysis affected X-ray radiation induced cell death...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28657858/screening-for-bovine-tuberculosis-in-african-buffalo-syncerus-caffer-in-ngorongoro-conservation-area-northern-tanzania-implications-for-public-health
#13
Bugwesa Z Katale, Robert D Fyumagwa, Eblate E Mjingo, Kuya Sayalel, Emmanuel K Batamuzi, Mecky I Matee, Julius D Keyyu, Justice Muumba, Maulid Mdaki, Erasto V Mbugi, Mark M Rweyemamu, Donald G Mpanduji
In the Ngorongoro Conservation Area (NCA), Tanzania, where wildlife and livestock interaction is intense, greater potential for intra- and interspecies disease transmission is expected. We assessed the prevalence of bovine tuberculosis in African buffalo (Syncerus caffer) residing on the valley floor of the crater in the NCA. Apparently healthy animals were randomly selected from herds in nine sites of the Ngorongoro Crater. Syncerus caffer buffalo herds were located using very high-frequency radio-aided rangers positioned in various observation points around the crater in the NCA...
June 28, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28657629/fluorescent-sensing-and-selective-adsorption-properties-of-metal-organic-frameworks-with-mixed-tricarboxylate-and-1h-imidazol-4-yl-containing-ligands
#14
Zhi-Qiang Liu, Yue Zhao, Peng Wang, Yan-Shang Kang, Mohammad Azam, Saud I Al-Resayes, Xiao-Hui Liu, Qing-Yi Lu, Wei-Yin Sun
Herein, two metal-organic frameworks (MOFs), [Co4(μ3-OH)2(L)(BTB)2(H2O)3]·5.6H2O (1) and [Cd3(L)2(BTB)2(μ2-H2O)]·7.4H2O (2), based on 1,3-di(1H-imidazol-4-yl)benzene (L) and 1,3,5-tri(4-carboxyphenyl)benzene (H3BTB), respectively, have been achieved. Compound 1 is a porous three-dimensional (3D) framework with butterfly-like tetranuclear clusters as 7-connected nodes, and compund 2 is a 3D net with a different topology. Remarkably, compounds 1 and 2 exhibit selective adsorption of CO2 over N2 and methyl orange (MO) dye molecules...
July 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28650040/synthesis-functionalisation-and-post-synthetic-modification-of-bismuth-metal-organic-frameworks
#15
M Köppen, O Beyer, S Wuttke, U Lüning, N Stock
Two new bismuth metal-organic frameworks (Bi-MOFs) were discovered using high throughput experiments employing bismuth(iii) nitrate pentahydrate and triazine-2,4,6-triyl-tribenzoic acid (H3TATB). The reaction was carried out for long reaction times (∼5 d) in a water/DMF-mixture and resulted in the formation of [Bi2(O)(OH)(TATB)]·H2O (denoted as CAU-35). By switching to short reaction times and a methanol/DMF-mixture as the solvent, an analogue of CAU-7-BTB with the composition [Bi(TATB)]·DMF·6H2O (denoted as CAU-7-TATB) was obtained...
June 26, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28646863/fine-mapping-host-genetic-variation-underlying-outcomes-to-mycobacterium-bovis-infection-in-dairy-cows
#16
S Wilkinson, S C Bishop, A R Allen, S H McBride, R A Skuce, M Bermingham, J A Woolliams, E J Glass
BACKGROUND: Susceptibility to Mycobacterium bovis infection in cattle is governed in part by host genetics. However, cattle diagnosed as infected with M. bovis display varying signs of pathology. The variation in host response to infection could represent a continuum since time of exposure or distinct outcomes due to differing pathogen handling. The relationships between host genetics and variation in host response and pathological sequelae following M. bovis infection were explored by genotyping 1966 Holstein-Friesian dairy cows at 538,231 SNPs with three distinct phenotypes...
June 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28646151/optimal-surveillance-strategies-for-bovine-tuberculosis-in-a-low-prevalence-country
#17
Kimberly VanderWaal, Eva A Enns, Catalina Picasso, Julio Alvarez, Andres Perez, Federico Fernandez, Andres Gil, Meggan Craft, Scott Wells
Bovine tuberculosis (bTB) is a chronic disease of cattle that is difficult to control and eradicate in part due to the costly nature of surveillance and poor sensitivity of diagnostic tests. Like many countries, bTB prevalence in Uruguay has gradually declined to low levels due to intensive surveillance and control efforts over the past decades. In low prevalence settings, broad-based surveillance strategies based on routine testing may not be the most cost-effective way for controlling between-farm bTB transmission, while targeted surveillance aimed at high-risk farms may be more efficient for this purpose...
June 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28645578/the-electrophilic-character-of-quinones-is-essential-for-the-suppression-of-bach1
#18
Chuanyang Su, Zixuan Liu, Yawen Wang, Yuxin Wang, Erqun Song, Yang Song
The activation of nuclear factor erythroid 2-related factor 2 (Nrf2) is the most important cellular defense mechanisms against oxidative attack. BTB and CNC homology-1 (Bach1), like Kelch-like ECH-associated protein 1 (Keap1), is one of a negative regulator of Nrf2 that control antioxidant response elements (ARE)-dependent gene expressions. In the current study, we found that quinones show greater capacity than hydroquinones in nuclear Bach1 export, as well as ubiquitin-dependent Bach1 degradation in our experimental time frame...
June 20, 2017: Toxicology
https://www.readbyqxmd.com/read/28619756/alpha-particle-enhanced-blood-brain-tumor-barrier-permeabilization-in-glioblastomas-using-integrin-alpha-v-beta-3-targeted-liposomes
#19
Anirudh Sattiraju, Xiaobing Xiong, Darpan N Pandya, Thaddeus J Wadas, Ang Xuan, Yao Sun, Youngkyoo Jung, Kiran Kumar Solingapuram Sai, Jay F Dorsey, King C Li, Akiva Mintz
<span style="font-size: 11.0pt; line-height: 200%; color: windowtext;">Glioblastoma (GBM) is the most common primary malignant astrocytoma characterized by extensive invasion, angiogenesis, hypoxia and micrometastasis. Despite the relatively leaky nature of GBM blood vessels, effective delivery of anti-tumor therapeutics has been a major challenge due to the complications caused by the blood brain barrier (BBB) and the highly torturous nature of newly formed tumor vasculature (blood tumor barrier-BTB)...
June 15, 2017: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/28610788/evaluation-of-antigen-specific-interleukin-1%C3%AE-as-a-biomarker-to-detect-cattle-infected-with-mycobacterium-bovis
#20
Mahmoud M Elnaggar, Gaber S Abdellrazeq, Alaa Elsisy, Asmaa H Mahmoud, Abdelrazeq Shyboub, Martina Sester, Samy A Khaliel, Mahavir Singh, Helmy A Torky, William C Davis
Bovine tuberculosis (bTB) is a major world-wide health problem that has been difficult to control, due to the lack of an effective vaccine and limited ability of the tuberculin skin test (TST) and the ancillary whole blood interferon-gamma (IFN-γ) release assay (IGRA) to detect all infected animals. A 6 h cytokine flow cytometric IFN-γ (CFC) assay was developed in effort to overcome these limitations and expand methods for studying the mechanisms of bTB immunopathogenesis. The present study was conducted to evaluate IL-1β as a biomarker to use in conjunction with the IFN-γ CFC assay to improve the diagnostic accuracy for bTB...
July 2017: Tuberculosis
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