keyword
MENU ▼
Read by QxMD icon Read
search

BTB

keyword
https://www.readbyqxmd.com/read/29679497/ewsr1-patz1-gene-fusion-may-define-a-new-glioneuronal-tumor-entity
#1
Aurore Siegfried, Audrey Rousseau, Claude-Alain Maurage, Sarah Pericart, Yvan Nicaise, Frederic Escudie, David Grand, Alix Delrieu, Anne Gomez-Brouchet, Sophie Le Guellec, Camille Franchet, Sergio Boetto, Matthieu Vinchon, Jean-Christophe Sol, Franck-Emmanuel Roux, Valerie Rigau, Anne-Isabelle Bertozzi, David Tw Jones, Dominique Figarella-Branger, Emmanuelle Uro-Coste
We investigated the challenging diagnostic case of a ventricular cystic glioneuronal tumor with papillary features, by RNA sequencing using the Illumina TruSight RNA Fusion panel. We did not retrieve the SLC44A1-PRKCA fusion gene specific for papillary glioneuronal tumor, but an EWSR1-PATZ1 fusion transcript. RT-PCR followed by Sanger sequencing confirmed the EWSR1-PATZ1 fusion. It matched with canonic EWSR1 fusion oncogene, juxtaposing the entire N terminal transcriptional activation domain of EWSR1 gene and the C terminal DNA binding domain of a transcription factor gene, PATZ1...
April 21, 2018: Brain Pathology
https://www.readbyqxmd.com/read/29678719/carnosic-acid-attenuates-cartilage-degeneration-through-induction-of-heme-oxygenase-1-in-human-articular-chondrocytes
#2
Hiroyuki Ishitobi, Yohei Sanada, Yoshio Kato, Yasunari Ikuta, Sachi Shibata, Satoshi Yamasaki, Martin K Lotz, Kiminori Matsubara, Shigeru Miyaki, Nobuo Adachi
Osteoarthritis (OA) is common age-associated disease, and associated with joint pain, mobility limitations and compromised overall quality of life. OA treatment is currently limited to pain management and joint arthroplasty at end stage disease. Oxidative damage to cartilage extracellular matrix and cells is an important mechanism in joint aging and OA pathogenesis. Evidence from in vitro and in vivo models of OA suggests that pharmaceuticals and natural compounds with antioxidant properties reduce expression of mediators of OA pathogenesis and OA severity in animal models...
April 17, 2018: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29673083/fine-particle-matter-disrupts-the-blood-testis-barrier-by-activating-tgf-%C3%AE-3-p38-mapk-pathway-and-decreasing-testosterone-secretion-in-rat
#3
Jianhui Liu, Lihua Ren, Jialiu Wei, Jin Zhang, Yupeng Zhu, Xiangyang Li, Li Jing, Junchao Duan, Xianqing Zhou, Zhiwei Sun
Fine particle matter (PM) is correlated with male reproductive dysfunction in animals and humans, but the underlying mechanisms remain unknown. To investigate the toxic mechanism of PM, 32 male Sprague-Dawley (SD) rats were exposed to saline or PM2.5 with the doses of 1.8, 5.4, and 16.2 mg/kg.b.w. via intratracheal instillation, respectively, one time every 3 days, in total times for 30 days. Sperm concentration, hormone level, the expressions of BTB-associated protein and the mitogen-activated protein kinase (MAPK) pathway, tumor necrosis factor α and transforming growth factor β3 levels were detected...
April 19, 2018: Environmental Toxicology
https://www.readbyqxmd.com/read/29671801/lumbar-sympathetic-block-with-botulinum-toxin-type-a-and-type-b-for-the-complex-regional-pain-syndrome
#4
Yongki Lee, Chul Joong Lee, Eunjoo Choi, Pyung Bok Lee, Ho-Jin Lee, Francis Sahngun Nahm
A lumbar sympathetic ganglion block (LSB) is a therapeutic method for complex regional pain syndrome (CRPS) affecting the lower limbs. Recently, LSB with botulinum toxin type A and B was introduced as a novel method to achieve longer duration of analgesia. In this study, we compared the botulinum toxin type A (BTA) with botulinum toxin type B (BTB) in performing LSB on patients with CRPS. LSB was performed with either BTA or BTB on patients with CRPS in their lower extremities. The length of time taken for patients to return to the pre-LSB pain score and the adverse effect of LSB with BTA/BTB were investigated...
April 19, 2018: Toxins
https://www.readbyqxmd.com/read/29665387/the-essential-player-in-adipogenesis-grp78-is-a-novel-kctd15-interactor
#5
Giovanni Smaldone, Luciano Pirone, Angela Capolupo, Luigi Vitagliano, Maria Chiara Monti, Sonia Di Gaetano, Emilia Pedone
KCTD15 is a member of the K+ Channel Tetramerization Domain family, implicated in crucial physio-pathological processes. Recent evidences suggest that KCTD15 is an obesity-linked protein in humans and its Drosophila homologue is involved in food uptake. KCTD15 molecular mechanism in these processes is still unknown. To fill this gap, KCTD15 was biophysically characterized showing a folded, pentameric region endowed with a remarkable thermal stability. Notably, the C-terminal domain significantly contributes to the stabilization of the BTB N-terminal domain...
April 14, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29664901/genetic-profiling-of-mycobacterium-bovis-strains-from-slaughtered-cattle-in-eritrea
#6
Michael Kahsay Ghebremariam, Tiny Hlokwe, Victor P M G Rutten, Alberto Allepuz, Simeon Cadmus, Adrian Muwonge, Suelee Robbe-Austerman, Anita L Michel
Mycobacterium bovis (M.bovis) is the main causative agent for bovine tuberculosis (BTB) and can also be the cause of zoonotic tuberculosis in humans. In view of its zoonotic nature, slaughterhouse surveillance, potentially resulting in total or partial condemnation of the carcasses and organs, is conducted routinely.Spoligotyping, VNTR profiling, and whole genome sequencing (WGS)ofM. bovis isolated from tissues with tuberculosis-like lesions collected from 14 cattle at Eritrea's largest slaughterhouse in the capital Asmara, were conducted...
April 17, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29664133/coordinated-regulation-of-the-dorsal-ventral-and-anterior-posterior-patterning-of-xenopus-embryos-by-the-btb-poz-zinc-finger-protein-zbtb14
#7
Kimiko Takebayashi-Suzuki, Hidenori Konishi, Tatsuo Miyamoto, Tomoko Nagata, Misa Uchida, Atsushi Suzuki
During early vertebrate embryogenesis, bone morphogenetic proteins (BMPs) belonging to the transforming growth factor-β (TGF-β) family of growth factors play a central role in dorsal-ventral (DV) patterning of embryos, while other growth factors such as Wnt and fibroblast growth factor (FGF) family members regulate formation of the anterior-posterior (AP) axis. Although the establishment of body plan is thought to require coordinated formation of the DV and AP axes, the mechanistic details underlying this coordination are not well understood...
April 2018: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/29663013/bone-to-bone-integrations-were-complete-within-5-months-after-anatomical-rectangular-tunnel-anterior-cruciate-ligament-reconstruction-using-a-bone-patellar-tendon-bone-graft
#8
Hironari Masuda, Shuji Taketomi, Hiroshi Inui, Naoya Shimazaki, Nobuhiro Nishihara, Seikai Toyooka, Hirotaka Kawano, Takumi Nakagawa
PURPOSE: Anterior cruciate ligament (ACL) reconstruction using a bone-patellar tendon-bone (BTB) graft is known to provide secure fixation due to the direct bone-to-bone integration of the bone plug and bone tunnel. It is important to know the time required for bone integration when designing the postoperative rehabilitation protocol or deciding when the patient can return to competition-level activity, especially if the patient is an athlete. However, because reports are scarce, the period necessary for bone-to-bone integration after ACL reconstruction using a BTB graft remains unclear...
April 16, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29651960/targeting-brain-tumors-with-nanomedicines-overcoming-challenges-of-blood-brain-barrier
#9
Nagendra S Ningaraj, Polluru L Reddy, Divya Khaitan
This review elucidates ongoing research, which show improved delivery of anticancer drugs alone and/ or enclosed in carriers collectively called nanomedicines to cross the Blood brain barrier (BBB) / blood-brain tumor barrier (BTB) to kill tumor cells and impact patient survival. We highlighted various advances in understanding the mechanism of BTB function that impact on anticancer therapeutics delivery. We discussed latest breakthroughs in developing pharmaceutical strategies, including nanomedicines and delivering them across BTB for brain tumor management and treatment...
April 12, 2018: Current Clinical Pharmacology
https://www.readbyqxmd.com/read/29628393/in-vivo-genetic-manipulation-of-spermatogonial-stem-cells-and-their-microenvironment-by-adeno-associated-viruses
#10
Satoshi Watanabe, Mito Kanatsu-Shinohara, Narumi Ogonuki, Shogo Matoba, Atsuo Ogura, Takashi Shinohara
Adeno-associated virus (AAV) penetrates the blood-brain barrier, but it is unknown whether AAV penetrates other tight junctions. Genetic manipulation of testis has been hampered by the basement membrane of seminiferous tubules and the blood-testis barrier (BTB), which forms between Sertoli cells and divides the tubules into basal and adluminal compartments. Here, we demonstrate in vivo genetic manipulation of spermatogonial stem cells (SSCs) and their microenvironment via AAV1/9. AAV1/9 microinjected into the seminiferous tubules penetrated both the basement membrane and BTB, thereby transducing not only Sertoli cells and SSCs but also peritubular cells and Leydig cells...
April 2, 2018: Stem Cell Reports
https://www.readbyqxmd.com/read/29611649/bovine-tuberculosis-outbreak-in-farmed-american-bison-bison-bison-in-poland
#11
M Krajewska-Wędzina, W Olech, M Kozińska, E Augustynowicz-Kopeć, M Weiner, K Szulowski
Poland has been an officially bovine tuberculosis (bTB) free country for the last seven years. The problem currently observed is the increasing number of new cases of bTB in wild species, kept in a farmed herd and free-living herd: European bison (Bison bonasus), wild boar (Sus scrofa), wolves (Canis lupus) and red deer (Cervus elaphus). This article presents the case of Mycobacterium caprae transmission to an American bison (Bison bison) herd kept on a private farm in Eastern Poland.
December 2017: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/29590647/mir-142-3p-inhibits-tgf-%C3%AE-3-induced-blood-testis-barrier-impairment-by-targeting-lethal-giant-larvae-homolog-2
#12
Ying Xu, Weixing Wu, Yunxia Fan, Shuyi Jiang, Xiaoyu Jia, Wenhui Su
BACKGROUND/AIMS: Transforming growth factor-β3 (TGF-β3) has been proved to perturb the blood-testis barrier (BTB) by accelerating junction protein endocytosis in Sertoli cells (SCs) to accommodate the traversing of preleptotene spermatocytes across the BTB around stage VIII in rat. Yet the molecular network underlying the impairment of TGF-β3 on BTB integrity is not fully elucidated. Our study herein was designed to investigate the participation of microRNA-142-3p (miR-142-3p), which has been reported to affect TGF-β3 signaling via different pathways, during BTB dynamics and the corresponding mechanisms...
March 22, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29587386/co%C3%A2-and-co%C3%A2-mixed-cluster-secondary-building-unit-approach-toward-a-three-dimensional-metal-organic-framework-with-permanent-porosity
#13
Meng-Yao Chao, Wen-Hua Zhang, Jian-Ping Lang
Large and permanent porosity is the primary concern when designing metal-organic frameworks (MOFs) for specific applications, such as catalysis and drug delivery. In this article, we report a MOF Co11 (BTB)₆(NO₃)₄(DEF)₂(H₂O)14 ( 1 , H₃BTB = 1,3,5-tris(4-carboxyphenyl)benzene; DEF = N , N -diethylformamide) via a mixed cluster secondary building unit (SBU) approach. MOF 1 is sustained by a rare combination of a linear trinuclear Co₃ and two types of dinuclear Co₂ SBUs in a 1:2:2 ratio. These SBUs are bridged by BTB ligands to yield a three-dimensional (3D) non-interpenetrated MOF as a result of the less effective packing due to the geometrically contrasting SBUs...
March 25, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29584698/loss-of-one-or-two-patz1-alleles-has-a-critical-role-in-the-progression-of-thyroid-carcinomas-induced-by-the-ret-ptc1-oncogene
#14
Mario Monaco, Giuseppe Palma, Michela Vitiello, Anna Capiluongo, Barbara D'Andrea, Emilia Vuttariello, Antonio Luciano, Laura Cerchia, Gennaro Chiappetta, Claudio Arra, Alfredo Fusco, Monica Fedele
POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) is an emerging cancer-related gene that is downregulated in different human malignancies, including thyroid cancer, where its levels gradually decrease going from papillary thyroid carcinomas (PTC) to poorly differentiated and undifferentiated highly aggressive anaplastic carcinomas (ATC). The restoration of PATZ1 expression in thyroid cancer cells reverted their malignant phenotype by inducing mesenchymal-to-epithelial transition, thus validating a tumor suppressor role for PATZ1 and suggesting its involvement in thyroid cancer progression...
March 27, 2018: Cancers
https://www.readbyqxmd.com/read/29567192/mof-based-fluorescent-assay-of-xanthine-oxidase-for-rapid-inhibitor-screening-with-real-time-kinetics-monitoring
#15
Lan Chang, Xi-Yuan Yao, Qiao Liu, Di Ning, Qian Wang, Xiao-Meng Du, Wen-Juan Ruan, Yue Li
The activity assay of xanthine oxidase (XO) is of great application value in clinical diagnosis because the abnormal level of this enzyme is related to a series of pathological states. In this work, a Zr based metal-organic framework (BTB-MOF) with stable photoluminescence in pure water and buffer solution was synthesized. The examination about the fluorescent responses of this material to xanthine and its oxidation product, uric acid, showed that, although both of them affected the emission of BTB-MOF in quenching form, the efficiencies presented much difference...
June 1, 2018: Talanta
https://www.readbyqxmd.com/read/29560577/bph1-a-novel-substrate-receptor-of-crl3-plays-a-repressive-role-in-aba-signal-transduction
#16
Og-Geum Woo, Soon-Hee Kim, Seok Keun Cho, Sang-Hoon Kim, Han Nim Lee, Taijoon Chung, Seong Wook Yang, Jae-Hoon Lee
BPH1 acts as a substrate receptor of CRL3 complex and negatively regulates ABA-mediated cellular responses. The study on its function provides information that helps further understand the relationship between ABA signaling and UPS. Abscisic acid (ABA) plays a crucial role in a variety of cellular processes, including seed dormancy, inhibition of seedling growth, and drought resistance in plants. Cullin3-RING E3 ligase (CRL3) complex is a type of multi-subunit E3 ligase, and BTB/POZ protein, a component of CRL3 complex, functions as a receptor to determine a specific substrate...
March 21, 2018: Plant Molecular Biology
https://www.readbyqxmd.com/read/29560355/limitations-of-using-il-17a-and-ifn-%C3%AE-induced-protein-10-to-detect-bovine-tuberculosis
#17
Ting Xin, Xintao Gao, Hongjun Yang, Pingjun Li, Qianqian Liang, Shaohua Hou, Xiukun Sui, Xiaoyu Guo, Weifeng Yuan, Hongfei Zhu, Jiabo Ding, Hong Jia
Bovine tuberculosis (bTB) is primarily caused by infection with Mycobacterium bovis , which belongs to the Mycobacterium tuberculosis complex. The airborne route is considered the most common for transmission of M. bovis , and more than 15% of cattle with bTB shed the Mycobacterium , which can be detect by nested PCR to amplify mycobacterial mpb 70 from a nasal swab from a cow. To screen for cytokines fostering early and accurate detection of bTB, peripheral blood mononuclear cells were isolated from naturally M...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29559101/cross-reactive-immune-responses-in-cattle-arising-from-exposure-to-mycobacterium-bovis-and-non-tuberculous-mycobacteria
#18
A O Jenkins, E Gormley, N Gcebe, G T Fosgate, A Conan, C Aagaard, A L Michel, V P M G Rutten
Accurate diagnosis of tuberculosis in cattle may be compromised in areas where there are high rates of exposure to environmental/non-tuberculous mycobacteria (NTM). This cross reaction of immune responses to Mycobacterium bovis antigens shared with NTMs can result in reduced specificity of commonly used diagnostic tests including tuberculin skin tests and the interferon gamma assay (IFN-ɣ). In this study we assessed the cross-reactive immune responses of M. bovis (infected) and NTM exposed animals to M. bovis and M...
April 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29555420/a-genetically-selected-cyclic-peptide-inhibitor-of-bcl6-homodimerization
#19
Eliot L Osher, Francisco Castillo, Nagarajan Elumalai, Michael J Waring, Garry Pairaudeau, Ali Tavassoli
We report an inhibitor of the homodimeric protein-protein interaction of the BCL6 oncoprotein, identified from a genetically encoded SICLOPPS library of 3.2 million cyclic hexapeptides in combination with a bacterial reverse two-hybrid system. This cyclic peptide is shown to bind the BTB domain of BCL6, disrupts its homodimerization, and subsequent binding of the SMRT2 corepressor peptide.
March 9, 2018: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29552479/articulated-bone-block-for-posterior-cruciate-ligament-reconstruction-using-bone-patellar-tendon-bone-autograft-surgical-technique-to-facilitate-graft-passage
#20
Ramón Cugat, Eduard Alentorn-Geli, Xavier Cuscó, Jordi Navarro, Gilbert Steinbacher, Pedro Álvarez-Díaz, Roberto Seijas, David Barastegui, Montse García-Balletbó
Posterior cruciate ligament reconstruction using the transtibial technique provides successful clinical outcomes. However, a bone-patellar tendon-bone (BTB) autograft with the transtibial technique has not been used by some surgeons because of concerns with graft passage from the tibial to the femoral tunnels (sharp turn) that can damage graft fibers. In the present surgical technique, an arthroscopic, transtibial, single-bundle technique for posterior cruciate ligament reconstruction using the BTB autograft with an easy and effective technical tip to facilitate graft passage is presented...
February 2018: Arthroscopy Techniques
keyword
keyword
70991
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"