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G Iakimova, S Dimitrova, T Burté
OBJECTIVES: Computer-delivered Cognitive Behavioral Therapies (C-CBT) are emerging as therapeutic techniques which contribute to overcome the barriers of health care access in adult populations with depression. The C-CBTs provide CBT techniques in a highly structured format comprising a number of educational lessons, homework, multimedia illustrations and supplementary materials via interactive computer interfaces. Programs are often administrated with a minimal or regular support provided by a clinician or a technician via email, telephone, online forums, or during face-to-face consultations...
October 10, 2016: L'Encéphale
Juyoung Park, Muna Aryal, Natalia Vykhodtseva, Yong-Zhi Zhang, Nathan McDannold
Drug delivery in brain tumors is challenging because of the presence of blood-brain barrier (BBB) and the blood-tumor barrier (BTB). Focused ultrasound (FUS) combined with microbubbles can enhance the permeability of the BTB in brain tumors, as well as disrupting the BBB in the surrounding tissue. In this study, dynamic contrast-enhanced Magnetic Resonance Imaging (DCE-MRI) was used to characterize FUS-induced permeability changes in a rat glioma model and in the normal brain and to investigate the relationship between these changes and the resulting concentration of the chemotherapy agent doxorubicin (DOX)...
October 11, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
Arata Hidano, Tim E Carpenter, Mark A Stevenson, M Carolyn Gates
Many countries implement regionalisation as a measure to control economically important livestock diseases. Given that regionalisation highlights the difference in disease risk between animal subpopulations, this may discourage herd managers in low-risk areas from purchasing animals from high-risk areas to protect the disease-free status of their herds. Using bovine tuberculosis (bTB) in New Zealand as a case example, we develop a novel network simulation model to predict how much the frequency of cattle movements between different disease control areas (DCAs) could theoretically change if herd managers adopted the safest practices (preferentially purchasing cattle from areas with the lowest risk of bTB), if herd managers adopted the riskiest practices (preferentially purchasing cattle from areas with the greatest risk of bTB), or if herd managers made trade decisions completely at random (purchasing cattle without consideration for bTB disease risk)...
October 1, 2016: Preventive Veterinary Medicine
Zhao Zhang, Emre Turer, Xiaohong Li, Xiaoming Zhan, Mihwa Choi, Miao Tang, Amanda Press, Steven R Smith, Adeline Divoux, Eva Marie Y Moresco, Bruce Beutler
We describe a metabolic disorder characterized by lipodystrophy, hepatic steatosis, insulin resistance, severe diabetes, and growth retardation observed in mice carrying N-ethyl-N-nitrosourea (ENU)-induced mutations. The disorder was ascribed to a mutation of kelch repeat and BTB (POZ) domain containing 2 (Kbtbd2) and was mimicked by a CRISPR/Cas9-targeted null allele of the same gene. Kbtbd2 encodes a BTB-Kelch family substrate recognition subunit of the Cullin-3-based E3 ubiquitin ligase. KBTBD2 targeted p85α, the regulatory subunit of the phosphoinositol-3-kinase (PI3K) heterodimer, causing p85α ubiquitination and proteasome-mediated degradation...
October 5, 2016: Proceedings of the National Academy of Sciences of the United States of America
Ripla Arora, Diana J Laird
Sertoli cells in the adult testis serve a secretory function and have a key structural role in the blood testis barrier (BTB). The BTB prevents meiotic spermatocytes from entering the blood and mounting an immune response. Spermatogonial maturation proceeds from the periphery of the seminiferous tubules towards the lumen, while maintaining constant contact with Sertoli cells. This article is protected by copyright. All rights reserved.
October 3, 2016: Molecular Reproduction and Development
S H Downs, J M Broughan, A V Goodchild, P A Upton, P A Durr
Field surveillance of British cattle using the single intradermal comparative cervical tuberculin (SICCT) test shows a higher incidence rate of bovine tuberculosis (bTB) in dairy compared to beef herds, but a lower probability of post-mortem examination confirmed (PMC) Mycobacterium bovis infection in dairy herds. A cross-sectional study was conducted to compare animal level differences in bTB detection between dairy and non-dairy cattle in Great Britain. During the period from 2002 to 2005, 200 (41% dairy) reactors in the SICCT test (standard interpretation) were randomly selected, and 200 in-contact cattle (43% dairy) were purposively selected from bTB-infected herds...
October 2016: Veterinary Journal
Hang Xu, Bin Zhai, Chun-Shuai Cao, Bin Zhao
A novel three-dimensional lanthanide-organic framework {[Eu(BTB)(phen)]·4.5DMF·2H2O}n (1) has been synthesized. Structural characterization suggests that framework 1 possesses one-dimensional channels with potential pore volume, and the large channels in the framework can capture CO2. Interestingly, investigations on the cycloaddition reaction of CO2 and epoxides reveal that compound 1 can be considered as an efficient catalyst for CO2 fixation with epoxides under 1 atm pressure. Importantly, 1 can be reused at least five times without any obvious loss in catalytic activity...
October 3, 2016: Inorganic Chemistry
Kosaku Sawada, Richard J Miron, Dominic Leiser, Jordi Caballé-Serrano, Dieter D Bosshardt, Benoit Schaller, Daniel Buser, Reinhard Gruber
Extracorporeal irradiation sterilizes resected tumor bone used as autografts in reconstruction surgery. Therapeutic irradiation is a standard technique in head and neck cancer therapy that aims to preserve organ function. Bone irradiation has a complex, mostly inhibitory, effect on remodeling and regeneration, although the underlying mechanisms are still not fully understood. It remains unclear if extracorporeal irradiation affects the paracrine-like activity of the corresponding autografts. We recently reported that bone-conditioned medium from autogenous bone chips contains a number of factors that might affect cell activity...
2016: Journal of Oral Science
Qiang Zhao, Yi-Ran Ren, Qing-Jie Wang, Xiao-Fei Wang, Chun-Xiang You, Yu-Jin Hao
Fe homeostasis is crucial for plant growth and development. A network of bHLH transcription factors (TFs) positively regulates Fe uptake during iron deficiency. However, their upregulation or overexpression leads to Fe overload and ROS generation, thereby damaging the plants. Here, we found that two BTB/TAZ proteins, MdBT1 and MdBT2, interact with the MbHLH104 protein in apple. In addition, the function of MdBT2 was characterized as a regulator of MdbHLH104 degradation via ubiquitination and the 26S proteosome pathway, thereby controlling the activity of plasma membrane H+-ATPases and the acquisition of iron...
September 22, 2016: Plant Physiology
Tomomi Kotoku, Koji Kosaka, Miki Nishio, Yasumasa Ishida, Masashi Kawaichi, Eishou Matsuda
The molecular mechanisms underlying mesodermal and cardiac specification from embryonic stem cells (ESCs) are not fully understood. Here, we showed that the BTB domain-containing zinc finger protein CIBZ is expressed in mouse ESCs but is dramatically downregulated during ESC differentiation. CIBZ deletion in ESCs induced specification toward mesoderm phenotypes and their differentiation into cardiomyocytes, whereas overexpression of CIBZ delayed these processes. During ESC differentiation, CIBZ loss-and-gain-of-function data indicate that CIBZ negatively regulates the expressions of Brachyury (T) and Mesp1, the key transcriptional factors responsible for the specification of mammalian mesoderm and cardiac progenitors, respectively...
2016: Scientific Reports
Jizhou Shi, Wanzhen Li, Xiping Ding
BACKGROUND: The protein encoded by ZBTB20 is a member of the POK family, whose members function as transcriptional repressors through interactions mediated by their conserved C2H2 Krüppel-type zinc finger and BTB/POZ domains. Polymorphisms in ZBTB20 appeared to be associated with gastric and esophageal cancer susceptibility in biological models, but the results of these studies were inconclusive. Therefore, we conducted a meta-analysis by pooling all available data to assess the exact association between the ZBTB20 rs9841504 polymorphism and gastric and esophageal cancer susceptibility...
September 9, 2016: International Journal of Biological Markers
Ying Gao, C Yan Cheng
Cell polarity is crucial to development since apico-basal polarity conferred by the 3 polarity protein modules (or complexes) is essential during embryogenesis, namely the Par (partition defective)-, the CRB (Crumbs)-, and the Scribble-based polarity protein modules. While these protein complexes and their component proteins have been extensively studied in Drosophila and C. elegans and also other mammalian tissues and/or cells, their presence and physiological significance in the testis remain unexplored until the first paper on the Par-based protein published in 2008...
May 2016: Spermatogenesis
Ricardo César Tavares Carvalho, Sidra Ezidio Gonçalves Vasconcellos, Marina de Azevedo Issa, Paulo Martins Soares Filho, Pedro Moacyr Pinto Coelho Mota, Flábio Ribeiro de Araújo, Ana Carolina da Silva Carvalho, Harrison Magdinier Gomes, Philip Noel Suffys, Eduardo Eustáquio de Souza Figueiredo, Vânia Margaret Flosi Paschoalin
Mycobacterium bovis is the causative agent of bovine tuberculosis (BTB), the pathogen responsible for serious economic impact on the livestock sector. In order to obtain data on isolated M. bovis strains and assist in the control and eradication program for BTB, a cross sectional descriptive molecular epidemiology study in the Brazilian Midwest was conducted. Through spoligotyping and 24-loci MIRU-VNTR methods, 37 clinical isolates of M. bovis circulating in the region were analyzed, 10 isolated from the state of Mato Grosso, 12 from the state of Mato Grosso do Sul and 15 from the state of Goiás...
2016: PloS One
Shari Fell, Stephanie Bröckl, Mathias Büttner, Anna Rettinger, Pia Zimmermann, Reinhard K Straubinger
BACKGROUND: Bovine tuberculosis (bTB), which is caused by Mycobacterium bovis and M. caprae, is a notifiable animal disease in Germany. Diagnostic procedure is based on a prescribed protocol that is published in the framework of German bTB legislation. In this protocol small sample volumes are used for DNA extraction followed by real-time PCR analyses. As mycobacteria tend to concentrate in granuloma and the infected tissue in early stages of infection does not necessarily show any visible lesions, it is likely that DNA extraction from only small tissue samples (20-40 mg) of a randomly chosen spot from the organ and following PCR testing may result in false negative results...
2016: BMC Microbiology
F J Salguero, S Gibson, W Garcia-Jimenez, J Gough, T S Strickland, H M Vordermeier, B Villarreal-Ramos
Cattle vaccination against bovine tuberculosis (bTB) has been proposed as a supplementary method to help control the incidences of this disease. Bacillus Calmette-Guérin (BCG) is currently the only viable candidate vaccine for immunization of cattle against bTB, caused by Mycobacterium bovis (M. bovis). In an attempt to characterize the differences in the immune response following M. bovis infection between BCG-vaccinated and non-vaccinated animals, a combination of gross pathology, histopathology and immunohistochemical (IHC) analyses was used...
September 11, 2016: Transboundary and Emerging Diseases
Ying Gao, Dolores D Mruk, Wing-Yee Lui, Will M Lee, C Yan Cheng
During the release of sperm at spermiation, a biologically active F5-peptide, which can disrupt the Sertoli cell tight junction (TJ) permeability barrier, is produced at the site of the degenerating apical ES (ectoplasmic specialization). This peptide coordinates the events of spermiation and blood-testis barrier (BTB) remodeling at stage VIII of the epithelial cycle, creating a local apical ES-BTB axis to coordinate cellular events across the epithelium. The mechanism(s) by which F5-peptide perturbs BTB restructuring, and its involvement in apical ES dynamics remain unknown...
September 7, 2016: Oncotarget
Zhepeng Liu, Feifei Song, Zhi-Li Ma, Qiushuang Xiong, Jingwen Wang, Deyin Guo, Guihong Sun
Potassium channel tetramerization domain containing 1 (KCTD1) family members have a BTB/POZ domain, which can facilitate protein-protein interactions involved in the regulation of different signaling pathways. KCTD proteins have potential Zn(2+)/Cu(2+) binding sites with currently unknown structural and functional roles. We investigated potential Cu(2+)-specific effects on KCTD1 using circular dichroism, turbidity measurement, fluorescent dye binding, proteinase K (PK) digestion, cell proliferation and apoptosis assays...
2016: Scientific Reports
Jun Li, Stefano Gottardi, Leonid Solianyk, Juan Carlos Moreno-López, Meike Stöhr
The self-assembly of 1,3,5-benzenetribenzoic acid (BTB) molecules on both Cu(111) and epitaxial graphene grown on Cu(111) were studied by scanning tunneling microscopy (STM) and low-energy electron diffraction (LEED) under ultrahigh vacuum conditions. On Cu(111), the BTB molecules were found to mainly arrange in close-packed structures through H-bonding between the (partially) deprotonated carboxylic acid groups. In addition, porous structures formed by intact BTB molecules-and also based on H-bonding-were observed...
August 18, 2016: Journal of Physical Chemistry. C, Nanomaterials and Interfaces
Noriyuki Suetsugu, Atsushi Takemiya, Sam-Geun Kong, Takeshi Higa, Aino Komatsu, Ken-Ichiro Shimazaki, Takayuki Kohchi, Masamitsu Wada
In green plants, the blue light receptor kinase phototropin mediates various photomovements and developmental responses, such as phototropism, chloroplast photorelocation movements (accumulation and avoidance), stomatal opening, and leaf flattening, which facilitate photosynthesis. In Arabidopsis, two phototropins (phot1 and phot2) redundantly mediate these responses. Two phototropin-interacting proteins, NONPHOTOTROPIC HYPOCOTYL 3 (NPH3) and ROOT PHOTOTROPISM 2 (RPT2), which belong to the NPH3/RPT2-like (NRL) family of BTB (broad complex, tramtrack, and bric à brac) domain proteins, mediate phototropism and leaf flattening...
September 13, 2016: Proceedings of the National Academy of Sciences of the United States of America
Yuefeng Zhu, Jie Shen, Qun Cheng, Yongqian Fan, Weilong Lin
OBJECTIVE: To study the relationship of plasma homocysteine (Hcy), bone turnover biomarkers (BTB), and bone mineral density (BMD) with osteoporotic fracture (OPF) in elderly people. METHODS: Eighty-two patients (aged 65 years or older) admitted to our orthopedics department between October 2014 and May 2015 were randomly divided into three groups: 1) OPF group: 39 cases with the mean age 81.82±5.49 years, which included 24 females and 15 males; 2) high-energy fracture (HEF) group: 22 cases with the mean age 78...
2016: Clinical Interventions in Aging
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