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https://www.readbyqxmd.com/read/29230403/farmer-and-veterinarian-attitudes-towards-the-bovine-tuberculosis-eradication-programme-in-spain-what-is-going-on-in-the-field
#1
Giovanna Ciaravino, Patricia Ibarra, Ester Casal, Sergi Lopez, Josep Espluga, Jordi Casal, Sebastian Napp, Alberto Allepuz
The effectiveness of health interventions against bovine tuberculosis (bTB) is influenced by several "non-biological" factors that may hamper bTB detection and control. Although the engagement of stakeholders is a key factor for the eradication programme's success, social factors have been often ignored in the control programmes of animal diseases, especially in developed countries. In this study, we used a qualitative approach to investigate perceptions, opinions, attitudes, and beliefs of farmers, and veterinarians who may influence the effectiveness of the Spanish bTB eradication programme...
2017: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29222143/consulting-on-btb-in-northern-ireland
#2
(no author information available yet)
No abstract text is available yet for this article.
December 2017: Veterinary Record
https://www.readbyqxmd.com/read/29212913/molecular-characterisation-of-mycobacterium-caprae-strains-isolated-in-poland
#3
Monika Krajewska-Wędzina, Monika Kozińska, Blanka Orłowska, Marcin Weiner, Krzysztof Szulowski, Ewa Augustynowicz-Kopeć, Krzysztof Anusz, Noel H Smith
Bovine tuberculosis (bovine TB, bTB) is caused by bovine bacilli: Mycobacterium bovis and M caprae The studies conducted in Poland, in the National Bovine Tuberculosis Reference Laboratory in the Department of Microbiology of the National Veterinary Research Institute in Pulawy, show that animal tuberculosis in Poland is also caused by M caprae We here describe the identification and genotypic assessment of 52 isolates of M caprae obtained from Polish cattle and wild animals over the last five years. We show that strains isolated from bison have significant genotypic diversity and are distinct compared with the genotypes of strains isolated from cattle...
December 6, 2017: Veterinary Record
https://www.readbyqxmd.com/read/29208072/risk-based-strategies-for-surveillance-of-tuberculosis-infection-in-cattle-for-low-risk-areas-in-england-and-scotland
#4
L C M Salvador, M Deason, J Enright, P R Bessell, R R Kao
Disease surveillance can be made more effective by either improving disease detection, providing cost savings, or doing both. Currently, cattle herds in low-risk areas (LRAs) for bovine tuberculosis (bTB) in England are tested once every 4 years. In Scotland, the default herd testing frequency is also 4 years, but a risk-based system exempts some herds from testing altogether. To extend this approach to other areas, a bespoke understanding of at-risk herds and how risk-based surveillance can affect bTB detection is required...
December 6, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/29207095/upregulation-of-zbtb7a-exhibits-a-tumor-suppressive-role-in-gastric-cancer-cells
#5
Guang Sun, Bo Peng, Quan Xie, Jianwen Ruan, Xianwen Liang
Gastric cancer presents as a complex solid tumor and is the third leading cause of global cancer‑associated mortality. The genetic alterations in gastric cancer remain unclear and deserve further investigation. Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival. ZBTB7A belongs to the POZ/BTB and Kruppel transcription factor family...
November 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29205877/molecular-epidemiology-of-mycobacterium-tuberculosis-complex-strains-isolated-from-livestock-and-wild-animals-in-italy-suggests-the-need-for-a-different-eradication-strategy-for-bovine-tuberculosis
#6
B Amato, V Di Marco Lo Presti, E Gerace, M T Capucchio, M Vitale, P Zanghì, M L Pacciarini, C Marianelli, M B Boniotti
Bovine tuberculosis (bTB) is an important zoonosis, which has been re-emerging in different ecological scenarios. In Sicily, Italy, from 2004 to 2014, an anatomopathological survey for tuberculosis-like lesions both in farmed and wild animals was performed. The isolates were genotyped using spoligotyping and Mycobacterial Interspersed Repetitive Units-Variable Number of Tandem Repeats (MIRU-VNTR) techniques. High prevalence of lesions was observed for cattle (4%), pigs (4.9%) and wild boars (6.8%), and a total of 625 Mycobacterium bovis isolates were identified...
December 3, 2017: Transboundary and Emerging Diseases
https://www.readbyqxmd.com/read/29186807/the-poz-btb-and-at-hook-containing-zinc-finger-1-patz1-transcription-regulator-physiological-functions-and-disease-involvement
#7
REVIEW
(no author information available yet)
PATZ1 is a zinc finger protein, belonging to the POZ domain Krüppel-like zinc finger (POK) family of architectural transcription factors, first discovered in 2000 by three independent groups. Since that time accumulating evidences have shown its involvement in a variety of biological processes (i.e., embryogenesis, stemness, apoptosis, senescence, proliferation, T-lymphocyte differentiation) and human diseases. Here we summarize these studies with a focus on the PATZ1 emerging and controversial role in cancer, where it acts as either a tumor suppressor or an oncogene...
November 24, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29183964/regulation-of-blood-testis-barrier-assembly-in-vivo-by-germ-cells
#8
Xiao-Yu Li, Yan Zhang, Xiu-Xia Wang, Cheng Jin, Yu-Qian Wang, Tie-Cheng Sun, Jian Li, Ji-Xin Tang, Alia Batool, Shou-Long Deng, Su-Ren Chen, C Yan Cheng, Yi-Xun Liu
The assembly of the blood-testis barrier (BTB) during postnatal development is crucial to support meiosis. However, the role of germ cells in BTB assembly remains unclear. Herein, KitW/KitWV mice were used as a study model. These mice were infertile, failing to establish a functional BTB to support meiosis due to c-Kit mutation. Transplantation of undifferentiated spermatogonia derived from normal mice into the testis of KitW/KitWV mice triggered functional BTB assembly, displaying cyclic remodeling during the epithelial cycle...
November 28, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29179619/urban-fine-particulate-matter-pm2-5-exposure-destroys-blood-testis-barrier-btb-integrity-through-excessive-ros-mediated-autophagy
#9
Yi Wei, Xi-Ning Cao, Xiang-Liang Tang, Lian-Ju Shen, Tao Lin, Da-Wei He, Sheng-de Wu, Guang-Hui Wei
BACKGROUND: Blood-testis barrier (BTB), constituted by tight junctions, adherens junctions and gap junctions, is important for spermatogenesis. PM2.5, is known to impair testicular functions and reproduction. However, its effects on BTB and the underlying mechanisms remain obscure. METHODS: In this study, we constructed a rat model to investigate the roles of autophagy in BTB toxicity induced by PM2.5. Sprague-Dawley rats were developmentally exposed to normal saline (NS) or PM2...
November 27, 2017: Toxicology Mechanisms and Methods
https://www.readbyqxmd.com/read/29179463/olaquindox-disrupts-tight-junction-integrity-and-cytoskeleton-architecture-in-mouse-sertoli-cells
#10
Di Wu, Chun-Jie Huang, Xiao-Fei Jiao, Zhi-Ming Ding, Jia-Yu Zhang, Fan Chen, Yong-Sheng Wang, Xiang Li, Li-Jun Huo
Sertoli cells, by creating an immune-privileged and nutrition supporting environment, maintain mammalian spermatogenesis and thereby holds the heart of male fertility. Olaquindox, an effective feed additive in livestock industry, could potentially expose human into the risk of biological hazards due to its genotoxicity and cytotoxicity, highlighting the significance of determining its bio-safety regarding human reproduction. Herein, we deciphered the detrimental effects of olaquindox on male fertility by mechanistically unraveling how olaquindox intervenes blood-testis barrier in mouse...
October 24, 2017: Oncotarget
https://www.readbyqxmd.com/read/29163184/silencing-of-nac1-expression-induces-cancer-cells-oxidative-stress-in-hypoxia-and-potentiates-the-therapeutic-activity-of-elesclomol
#11
Yi-Jie Ren, Xiao-Hui Wang, Cheng Ji, Yi-Di Guan, Xian-Jiu Lu, Xian-Rong Liu, Hong-Han Zhang, Ling-Chuan Guo, Qiong-Hua Xu, Wei-Dong Zhu, Zhi-Jun Ming, Jin-Ming Yang, Yan Cheng, Yi Zhang
In order to survive under conditions of low oxygen, cancer cells can undergo a metabolic switch to glycolysis and suppress mitochondrial respiration in order to reduce oxygen consumption and prevent excessive amounts of reactive oxygen species (ROS) production. Nucleus accumbens-1 (NAC1), a nuclear protein of the BTB/POZ gene family, has pivotal roles in cancer development. Here, we identified that NAC1-PDK3 axis as necessary for suppression of mitochondrial function, oxygen consumption, and more harmful ROS generation and protects cancer cells from apoptosis in hypoxia...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29158871/effects-of-novel-nitric-oxide-releasing-molecules-against-oxidative-stress-on-retinal-pigmented-epithelial-cells
#12
Valeria Pittalà, Annamaria Fidilio, Francesca Lazzara, Chiara Bianca Maria Platania, Loredana Salerno, Roberta Foresti, Filippo Drago, Claudio Bucolo
Oxidative stress is a hallmark of retinal degenerations such as age-related macular degeneration and diabetic retinopathy. Enhancement of heme oxygenase-1 (HO-1) activity in the retina would exert beneficial effects by protecting cells from oxidative stress, therefore promoting cell survival. Because a crosstalk exists between nitric oxide (NO) and HO-1 in promotion of cell survival under oxidative stress, we designed novel NO-releasing molecules also capable to induce HO-1. Starting from curcumin and caffeic acid phenethyl ester (CAPE), two known HO-1 inducers, the molecules were chemically modified by acylation with 4-bromo-butanoyl chloride and 2-chloro-propanoyl chloride, respectively, and then treated in the dark with AgNO3 to obtain the nitrate derivatives VP10/12 and VP10/39...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29158629/overexpression-of-lhsornpr1-a-npr1-like-gene-from-the-oriental-hybrid-lily-sorbonne-conferred-enhanced-resistance-to-pseudomonas-syringae-pv-tomato-dc3000-in-arabidopsis
#13
Le Wang, Zhihong Guo, Yubao Zhang, Yajun Wang, Guo Yang, Liu Yang, Li Wang, Ruoyu Wang, Zhongkui Xie
The non-expressor of the pathogenesis-related genes 1 (NPR1) is a master regulator in defense signaling of plants and plays a key role in basal and systemic acquired resistance. In this study, we isolated a NPR1-like gene from the oriental hybrid lily 'Sorbonne' (designated as LhSorNPR1) using rapid amplification of cDNA ends (RACE). The open reading frame of LhSorNPR1 consisted of 1854 bp, encoding a protein of 617 amino acids. Multiple sequence alignment revealed that LhSorNPR1 shares high similarity to NPR1-like proteins and characteristics of the BTB/POZ domain and ankyrin repeats...
October 2017: Physiology and Molecular Biology of Plants: An International Journal of Functional Plant Biology
https://www.readbyqxmd.com/read/29157368/livestock-as-sentinels-for-an-infectious-disease-in-a-sympatric-or-adjacent-living-wildlife-reservoir-host
#14
D P Anderson, A M Gormley, M Bosson, P G Livingstone, G Nugent
A central question to address in managing wildlife diseases is how much effort and resources are required to reduce infection prevalence to below a requisite threshold? This requires surveillance for infection in at least one species involved in the infection cycle, a process that is often expensive and time-consuming but one which could be enhanced using additional sources of readily-obtainable surveillance data. We demonstrate how surveillance data from ruminant livestock monitored for bovine tuberculosis (bTB) in New Zealand can be employed in spatially-explicit modelling to help predict the probability of freedom from Mycobacterium bovis infection in a sympatric wildlife reservoir species, the brushtail possum (Trichosurus vulpecula)...
December 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29155877/immune-response-profiles-of-calves-following-vaccination-with-live-bcg-and-inactivated-mycobacterium-bovis-vaccine-candidates
#15
E M D L van der Heijden, J Chileshe, J C M Vernooij, C Gortazar, R A Juste, I Sevilla, J E Crafford, V P M G Rutten, A L Michel
Conventional control and eradication strategies for bovine tuberculosis (BTB) face tremendous difficulties in developing countries; countries with wildlife reservoirs, a complex wildlife-livestock-human interface or a lack of veterinary and veterinary public health surveillance. Vaccination of cattle and other species might in some cases provide the only suitable control strategy for BTB, while in others it may supplement existing test-and-slaughter schemes. However, the use of live BCG has several limitations and the global rise of HIV/AIDS infections has furthermore warranted the exploration of inactivated vaccine preparations...
2017: PloS One
https://www.readbyqxmd.com/read/29152098/toxic-metabolites-sertoli-cells-and-y-chromosome-related-genes-are-potentially-linked-to-the-reproductive-toxicity-induced-by-mequindox
#16
Qianying Liu, Zhixin Lei, Menghong Dai, Xu Wang, Zonghui Yuan
Mequindox (MEQ) is a relatively new synthetic antibacterial agent widely applied in China since the 1980s. However, its reproductive toxicity has not been adequately performed. In the present study, four groups of male Kunming mice (10 mice/group) were fed diets containing MEQ (0, 25, 55 and 110 mg/kg in the diet) for up to 18 months. The results show that M4 could pass through the blood-testis barrier (BTB), and demonstrate that Sertoli cells (SCs) are the main toxic target for MEQ to induce spermatogenesis deficiency...
October 20, 2017: Oncotarget
https://www.readbyqxmd.com/read/29150642/rescue-of-pfos-induced-human-sertoli-cell-injury-by-overexpressing-a-p-fak-y407e-phosphomimetic-mutant
#17
Haiqi Chen, Ying Gao, Dolores D Mruk, Xiang Xiao, Constance M John, Paul J Turek, Wing-Yee Lui, Will M Lee, Bruno Silvestrini, C Yan Cheng
PFOS induces Sertoli cell injury using testicular cells isolated from rodent testes, but it remains unknown if PFOS has similar effects in humans. Herein, we maintained human Sertoli cells in a mitotically active state in vitro, thus enabling transfection experiments that altered gene expression to explore the molecular mechanism(s) underlying toxicant-induced cell injury. Human Sertoli cells obtained from men at ages 15, 23, 36 and 40 were cultured in vitro. These differentiated Sertoli cells remained mitotically active when cultured in the presence of 10% FBS (fetal bovine serum), with a replication time of ~1-3 weeks...
November 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29140403/klhl6-is-preferentially-expressed-in-germinal-center-derived-b-cell-lymphomas
#18
Christian A Kunder, Giovanna Roncador, Ranjana H Advani, Gabriela Gualco, Carlos E Bacchi, Jean M Sabile, Izidore S Lossos, Kexin Nie, Robert John Tibshirani, Michael R Green, Ash A Alizadeh, Yasodha Natkunam
Objectives: KLHL6 is a recently described BTB-Kelch protein with selective expression in lymphoid tissues and is most strongly expressed in germinal center B cells. Methods: Using gene expression profiling as well as immunohistochemistry with an anti-KLHL6 monoclonal antibody, we have characterized the expression of this molecule in normal and neoplastic tissues. Protein expression was evaluated in 1,058 hematopoietic neoplasms. Results: Consistent with its discovery as a germinal center marker, KLHL6 was positive mainly in B-cell neoplasms of germinal center derivation, including 95% of follicular lymphomas (106/112)...
November 20, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29137378/trastuzumab-distribution-in-an-in-vivo-and-in-vitro-model-of-brain-metastases-of-breast-cancer
#19
Tori B Terrell-Hall, Mohamed Ismail Nounou, Fatema El-Amrawy, Jessica I G Griffith, Paul R Lockman
Background: Drug and antibody delivery to brain metastases has been highly debated in the literature. The blood-tumor barrier (BTB) is more permeable than the blood-brain barrier (BBB), and has shown to have highly functioning efflux transporters and barrier properties, which limits delivery of targeted therapies. Methods: We characterized the permeability of (125)I-trastuzumab in an in-vivo, and fluorescent trastuzumab-Rhodamine123 (t-Rho123) in a novel microfluidic in-vitro, BBB and BTB brain metastases of breast cancer model...
October 13, 2017: Oncotarget
https://www.readbyqxmd.com/read/29128526/functional-analysis-of-cullin-3-e3-ligases-in-tumorigenesis
#20
REVIEW
Ji Cheng, Jianping Guo, Zhiwei Wang, Brian J North, Kaixiong Tao, Xiangpeng Dai, Wenyi Wei
Cullin 3-RING ligases (CRL3) play pivotal roles in the regulation of various physiological and pathological processes, including neoplastic events. The substrate adaptors of CRL3 typically contain a BTB domain that mediates the interaction between Cullin 3 and target substrates to promote their ubiquitination and subsequent degradation. The biological implications of CRL3 adaptor proteins have been well described where they have been found to play a role as either an oncogene, tumor suppressor, or can mediate either of these effects in a context-dependent manner...
November 8, 2017: Biochimica et Biophysica Acta
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