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https://www.readbyqxmd.com/read/28542131/aroclor1254-disrupts-the-blood-testis-barrier-by-promoting-endocytosis-and-degradation-of-junction-proteins-via-p38-mapk-pathway
#1
Xiaoyu Jia, Ying Xu, Weixing Wu, Yunxia Fan, Guoli Wang, Tianbiao Zhang, Wenhui Su
The blood-testis barrier (BTB) constituted by coexisting junction apparatus between Sertoli cells (SCs) plays an important role in spermatogenesis, which is a known target of various environmental toxicants. The commercial polychlorinated biphenyls mixture, Aroclor1254, has been shown to impair male reproduction by decreasing sperm count and affecting SC metabolism. This study was designed to investigate the effects of Aroclor1254 on the BTB integrity and elucidate the underlying mechanisms. We found that Aroclor1254 treatment in rats (1 or 3 mg/kg per day for 21 consecutive days) and in primary cultured SCs (5 or 10 μg/ml for 48 h) could induce BTB disruption via p38 MAPK pathway, concurrently with increments in junction proteins (JAM-A, N-cadherin, and β-catenin) endocytosis, and occludin ubiquitination...
May 25, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28537489/hydrogen-sulfide-as-a-potential-target-in-preventing-spermatogenic-failure-and-testicular-dysfunction
#2
Jing Wang, Wan Wang, Shuangyue Li, Yi Han, Ping Zhang, Guoliang Meng, Yujiao Xiao, Liping Xie, Xin Wang, Jiahao Sha, Qi Chen, Philip K Moore, Rui Wang, Wenpei Xiang, Yong Ji
AIMS: Testis and sperm are particularly susceptible to inflammation and oxidative stress. Although Hydrogen sulfide (H2S) has been considered as an important biological signaling molecule in inflammatory and oxidative stress processes, its role in male reproductive system was poorly understood. The aim of this study was to investigate the role of H2S in the regulation of male reproductive system. RESULTS: We found that both sub-fertile and infertile patients, especially asthenospermic patients, exhibited a decreased concentration of H2S in their seminal plasma and diminished expression of H2S-generating enzyme (cystathionine β-synthase, CBS) in sperm...
May 24, 2017: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28536120/hepatocyte-specific-sirtuin-6-deletion-predisposes-to-nonalcoholic-steatohepatitis-by-up-regulation-of-bach1-an-nrf2-repressor
#3
Sun-O Ka, In Hyuk Bang, Eun Ju Bae, Byung-Hyun Park
Sirtuin (Sirt)6 has been implicated in negative regulation of inflammation and lipid metabolism, although its function in the progression from simple steatosis to nonalcoholic steatohepatitis (NASH) remains to be defined. To explore the role of hepatocyte Sirt6 in NASH development, we generated hepatocyte-specific Sirt6 knockout (KO) mice that were fed a high-fat and high-fructose (HFHF) diet for 16 wk. HFHF-fed KO mice had increased hepatic steatosis and inflammation and aggravated glucose intolerance and insulin resistance compared with wild-type mice...
May 23, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28532992/assessment-of-concurrent-infection-with-bovine-viral-diarrhoea-virus-bvdv-and-mycobacterium-bovis-a-herd-level-risk-factor-analysis-from-northern-ireland
#4
A W Byrne, M Guelbenzu-Gonzalo, S A J Strain, S McBride, J Graham, A Lahuerta-Marin, R Harwood, D A Graham, S McDowell
Bovine viral diarrhoea virus (BVDV) is a significant pathogen of cattle, leading to severe economic and animal-welfare impacts. Furthermore, the pathogen has been associated with impacting the progression or spread of other pathogens (e.g. Mycobacterium bovis, the causative agent of bovine tuberculosis (bTB)). During this study we investigated (i) risk factors for BVDV at a herd-level and (ii) whether there was any association between BVDV and herd-level bTB risk. The data for this study were gathered from a voluntary BVDV control programme in Northern Ireland (2013-2015) based on the identification of virus positive animals through tissue tag testing of calves...
June 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28521256/antibody-detection-tests-improve-the-sensitivity-of-tuberculosis-diagnosis-in-cattle
#5
C Casal, J A Infantes, M A Risalde, A Díez-Guerrier, M Domínguez, I Moreno, B Romero, L de Juan, J L Sáez, R Juste, C Gortázar, L Domínguez, J Bezos
We evaluated the sensitivity (Se) of the single cervical intradermal tuberculin (SIT) test, two interferon-gamma (IFN-γ) assays and three different antibody detection techniques for bovine tuberculosis (bTB) diagnosis in 131 mixed beef breed cattle. The results of the diagnostic techniques performed over the whole herd, and over the animals confirmed as infected based on the presence of lesions compatible with the disease and/or M. bovis isolation were compared to determine apparent prevalence (AP) and Se...
May 11, 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28512252/epigenetic-regulation-of-zbtb18-promotes-glioblastoma-progression
#6
Vita Fedele, Fangping Dai, Anie Masilamani, Dieter Henrik Heiland, Eva Kling, Ana Gätjens-Sanchez, Roberto Ferrarese, Leonardo Platania, Soroush Doostkam, Hyunsoo Kim, Sven Nelander, Astrid Weyerbrock, Marco Prinz, Andrea Califano, Antonio Iavarone, Markus Bredel, Maria Stella Carro
Glioblastoma (GBM) is comprised of distinct subtypes characterized by their molecular profile. Mesenchymal identity in GBM has been associated with a comparatively unfavorable prognosis, primarily due to inherent resistance of these tumors to current therapies. The identification of molecular determinants of mesenchymal transformation could potentially allow for the discovery of new therapeutic targets. Zinc Finger and BTB Domain Containing 18 (ZBTB18/ZNF238/RP58) is a zinc finger transcriptional repressor with a crucial role in brain development and neuronal differentiation...
May 16, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28487282/regulation-of-spermatogenesis-by-a-local-functional-axis-in-the-testis-role-of-the-basement-membrane-derived-noncollagenous-1-domain-peptide
#7
Haiqi Chen, Dolores D Mruk, Will M Lee, C Yan Cheng
Spermatogenesis takes place in the epithelium of the seminiferous tubules of the testes, producing millions of spermatozoa per day in an adult male in rodents and humans. Thus, multiple cellular events that are regulated by an array of signaling molecules and pathways are tightly coordinated to support spermatogenesis. Here, we report findings of a local regulatory axis between the basement membrane (BM), the blood-testis barrier (BTB), and the apical ectoplasmic specialization (apical ES; a testis-specific, actin-rich adherens junction at the Sertoli cell-spermatid interface) to coordinate cellular events across the seminiferous epithelium during the epithelial cycle...
May 9, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28487230/assessment-of-antigenic-supplementation-of-bovine-purified-protein-derivative-for-diagnosis-of-subclinical-infection-with-mycobacterium-bovis-in-cattle
#8
A H Alvarez, A Gutiérrez-Ortega, V Gómez-Entzin, G Pérez-Mayorga, J Naranjo-Bastién, V González-Martínez, F Milián-Suazo, M Martínez-Velázquez, S Herrera-Rodríguez, E Hinojoza-Loza
Bovine tuberculosis (bTB) is usually diagnosed in vivo and ex vivo on the basis of delayed hypersensitivity reactions with a complex pool of antigens named bovine tuberculin (PPDB). The IFN-γ release assay (IGRA) for bTB is a blood-based assay that improves detection of infected cattle at early stages that escape skin testing. Improvements to IFN-γ testing with specific proteins have been performed to increase sensitivity. DosR regulon-related antigens are well known mycobacterial proteins expressed during the non-replicative phases of infection, this has been useful to improve the diagnosis of subclinical forms of TB in suspected individuals...
May 6, 2017: Microbial Pathogenesis
https://www.readbyqxmd.com/read/28480452/the-prevalence-of-tuberculosis-in-cattle-and-their-handlers-in-north-tongu-volta-region-ghana
#9
Esther A Amemor, S O Sackey, Nathaniel Yebuah, Raphael Deladem Folitse, Benjamin O Emikpe, E Afari, F Wurapa, C Ohuabunwo, K Addo, David Mensah, E Gaglo, Mark-Hansen, S Johnson, William Tasiame, D Amedzovor, D Nkunafa, Frank Bonsu
BACKGROUND: The need to understand the contribution of bovine tuberculosis (BTB) to the general tuberculosis burden in a poor resource setting is paramount. The aim of this study is to determine the burden of BTB among herdsmen and cattle in the North Tongu district of Volta Region in Ghana. MATERIALS AND METHODS: A cross- sectional study was conducted in the North Tongu District of the Volta Region between the period of October 2011- March 2012. A well-structured questionnaire was used to collect socio-demographic information and possible risk factor information on cattle from participants...
2017: African Journal of Infectious Diseases
https://www.readbyqxmd.com/read/28461702/bach-transcription-factors-in-innate-and-adaptive-immunity
#10
REVIEW
Kazuhiko Igarashi, Tomohiro Kurosaki, Rahul Roychoudhuri
BTB and CNC homology (BACH) proteins are transcriptional repressors of the basic region leucine zipper (bZIP) transcription factor family. Recent studies indicate widespread roles of BACH proteins in controlling the development and function of the innate and adaptive immune systems, including the differentiation of effector and memory cells of the B and T cell lineages, CD4(+) regulatory T cells and macrophages. Here, we emphasize similarities at a molecular level in the cell-type-specific activities of BACH factors, proposing that competitive interactions of BACH proteins with transcriptional activators of the bZIP family form a common mechanistic theme underlying their diverse actions...
May 2, 2017: Nature Reviews. Immunology
https://www.readbyqxmd.com/read/28460744/the-performance-of-the-interferon-gamma-assay-when-used-as-a-diagnostic-or-quality-assurance-test-in-mycobacterium-bovis-infected-herds
#11
T A Clegg, M Good, M Doyle, A Duignan, S J More, E Gormley
There are two different contexts in the Irish bTB eradication programme in which the interferon-gamma assay (IFN-γ) is applied. Firstly, the IFN-γ assay is applied routinely to high risk cohorts in herds with four or more reactors to the SICTT. The IFN-γ test is then carried out on blood samples submitted to the laboratory within 8h of collection (diagnostic testing). Secondly, the use of the IFN-γ assay has recently been extended to test SICTT reactors as part of a general quality assurance (QA) scheme to monitor the performance of the SICTT...
May 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28454655/toll-like-receptor-tlr-diversity-influences-mycobacterial-growth-in-african-buffalo
#12
Nikki le Roex, Anna Jolles, Brianna Beechler, Paul van Helden, Eileen Hoal
Understanding the role of wildlife in the maintenance or spread of emerging infectious diseases is a growing priority across the world. Bovine tuberculosis (BTB) is a chronic, infectious disease caused by Mycobacterium bovis (M. bovis). BTB is widespread within game reserves in southern Africa, and within these ecosystems the primary wildlife host of this disease is the African buffalo. We used a modified bacterial killing assay for mycobacteria to investigate the effect of Toll-like receptor (TLR) genetic diversity and demographic parameters on the ability of African buffalo to restrict mycobacterial growth...
May 2017: Tuberculosis
https://www.readbyqxmd.com/read/28450047/signaling-pathways-regulating-blood-tissue-barriers-lesson-from-the-testis
#13
REVIEW
Qing Wen, Elizabeth I Tang, Ying Gao, Tito T Jesus, Darren S Chu, Will M Lee, Chris K C Wong, Yi-Xun Liu, Xiang Xiao, Bruno Silvestrini, C Yan Cheng
Signaling pathways that regulate blood-tissue barriers are important for studying the biology of various blood-tissue barriers. This information, if deciphered and better understood, will provide better therapeutic management of diseases particularly in organs that are sealed by the corresponding blood-tissue barriers from systemic circulation, such as the brain and the testis. These barriers block the access of antibiotics and/or chemotherapeutical agents across the corresponding barriers. Studies in the last decade using the blood-testis barrier (BTB) in rats have demonstrated the presence of several signaling pathways that are crucial to modulate BTB function...
April 25, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28448585/impact-of-temperature-and-soil-type-on-mycobacterium-bovis-survival-in-the-environment
#14
Elodie Barbier, Murielle Rochelet, Laurent Gal, Maria Laura Boschiroli, Alain Hartmann
Mycobacterium bovis, the causative agent of the bovine tuberculosis (bTB), mainly affects cattle, its natural reservoir, but also a wide range of domestic and wild mammals. Besides direct transmission via contaminated aerosols, indirect transmission of the M. bovis between wildlife and livestock might occur by inhalation or ingestion of environmental substrates contaminated through infected animal shedding. We monitored the survival of M. bovis in two soil samples chosen for their contrasted physical and-chemical properties (i...
2017: PloS One
https://www.readbyqxmd.com/read/28447546/application-of-an-indicator-immobilized-gel-sheet-for-measuring-the-ph-surrounding-a-calcium-phosphate-based-biomaterial
#15
Taisuke Masuda, Hisataka Maruyama, Fumihito Arai, Takahisa Anada, Kaori Tsuchiya, Toshio Fukuda, Osamu Suzuki
The present study was designed to investigate the local microenvironment of octacalcium phosphate in a granule form upon biomolecules adsorption utilizing an indicator-immobilized-gel-sheet for measuring pH. We previously showed that octacalcium phosphate enhances bone regeneration during its progressive hydrolysis into hydroxyapatite if implanted in bone defects. The gel-sheet was made from a photocrosslinkable prepolymer solution, which can easily immobilize a pH indicator (bromothymol blue; BTB) in the hydrogel...
April 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28446721/senp3-grants-tight-junction-integrity-and-cytoskeleton-architecture-in-mouse-sertoli-cells
#16
Di Wu, Chun-Jie Huang, Faheem Ahmed Khan, Xiao-Fei Jiao, Xiao-Ming Liu, Nuruliarizki Shinta Pandupuspitasari, Rahim Dad Brohi, Li-Jun Huo
Germ cells develop in a sophisticated immune privileged microenvironment provided by specialized junctions contiguous the basement membrane of the adjacent Sertoli cells that constituted the blood-testis barrier (BTB) in seminiferous epithelium of testis in mammals. Deciphering the molecular regulatory machinery of BTB activity is central to improve male fertility and the role of post-translational modification including SUMOylation pathway is one of the key factors. Herein, we unveiled the mystery of the SUMO-2/3 specific protease SENP3 (Sentrin-specific protease 3) in BTB dynamics regulation...
April 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28439067/perfluorooctanesulfonate-pfos-induced-sertoli-cell-injury-through-a-disruption-of-f-actin-and-microtubule-organization-is-mediated-by-akt1-2
#17
Ying Gao, Haiqi Chen, Xiang Xiao, Wing-Yee Lui, Will M Lee, Dolores D Mruk, C Yan Cheng
PFOS (perfluorooctanesulfonate, or perfluorooctane sulfonic acid) is an anthropogenic fluorosurfactant widely used in consumer products. While its use in Europe, Canada and the U.S. has been banned due to its human toxicity, it continues to be used in China and other developing countries as a global pollutant. Herein, using an in vitro model of Sertoli cell blood-testis barrier (BTB), PFOS was found to induce Sertoli cell injury by perturbing actin cytoskeleton through changes in the spatial expression of actin regulatory proteins...
April 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28438684/two-spliced-isoforms-of-the-sex-determination-gene-fruitless-in-the-chinese-mitten-crab-eriocheir-sinensis
#18
Peiyao Li, Yuan Liu, Danli Luo, Chengwen Song, Zhaoxia Cui
The fruitless (fru) gene plays an important role in the sex determination pathway and courtship behavior of Drosophila melanogaster. In the present study, two fru isoforms (Esfru1 and Esfru2) were identified from the Chinese mitten crab Eriocheir sinensis. Sequence analysis showed that Esfru1 and Esfru2 were encoded by the same genomic locus and generated by alternative splicing of pre-mRNA. Esfru1 had all introns completely spliced out, while Esfru2 had a longer exon1 with an additional 78bp sequence. They both contained a conserved BTB domain which was also found in D...
April 22, 2017: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/28426770/correction-risk-factors-for-bovine-tuberculosis-btb-in-cattle-in-ethiopia
#19
Sintayehu W Dejene, Ignas M A Heitkönig, Herbert H T Prins, Fitsum A Lemma, Daniel A Mekonnen, Zelalem E Alemu, Tessema Z Kelkay, Willem F de Boer
[This corrects the article DOI: 10.1371/journal.pone.0159083.].
2017: PloS One
https://www.readbyqxmd.com/read/28420366/pirfenidone-attenuates-bleomycin-induced-pulmonary-fibrosis-in-mice-by-regulating-nrf2-bach1-equilibrium
#20
Yuan Liu, Fuai Lu, Lirong Kang, Zhihua Wang, Yongfu Wang
BACKGROUND: Oxidative stress is one of the important factors involved in the pathogenesis of idiopathic pulmonary fibrosis (IPF). The equilibrium of Nuclear factor-erythroid-related factor 2 (Nrf2)/[BTB (broad-complex, tramtrack and bric-a-brac) and CNC (cap'n'collar protein) homology 1, Bach1] determines the expression level of antioxidant factors, further regulating the function of oxidation/antioxidation capacity. Pirfenidone (PFD) is one of two currently for IPF therapy approved drugs...
April 18, 2017: BMC Pulmonary Medicine
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