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https://www.readbyqxmd.com/read/28731439/antihypertensive-treatment-is-associated-with-mri-derived-markers-of-neurodegeneration-and-impaired-cognition-a-propensity-weighted-cohort-study
#1
Jodi D Edwards, Joel Ramirez, Brandy L Callahan, Sheldon W Tobe, Paul Oh, Courtney Berezuk, Krista Lanctôt, Walter Swardfager, Sean Nestor, Alexander Kiss, Stephen Strother, Sandra E Black
BACKGROUND: Hypertension is an important risk factor for Alzheimer's disease (AD) and cerebral small vessel disease. Angiotensin converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are common anti-hypertensive treatments, but have differential effects on cortical amyloid. OBJECTIVE: The objective of this study was to evaluate associations between anti-hypertensive treatment, brain volume, and cognition, using a propensity-weighted analysis to account for confounding by indication...
July 17, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28729834/white-matter-hyperintensity-in-elderly-patients-with-diabetes-mellitus-is-associated-with-cognitive-impairment-functional-disability-and-a-high-glycoalbumin-glycohemoglobin-ratio
#2
Yoshiaki Tamura, Yoshiyuki Kimbara, Takuya Yamaoka, Ken Sato, Yuki Tsuboi, Remi Kodera, Yuko Chiba, Seijiro Mori, Yoshinori Fujiwara, Aya M Tokumaru, Hideki Ito, Takashi Sakurai, Atsushi Araki
Aims: Although evidence has accumulated that white matter hyperintensity (WMH) is associated with the deterioration of cognitive function and impairment of activities of daily living (ADL), the clinical relevance of WMH in elderly patients with diabetes mellitus (DM) is not still clear. The aim of this study was to examine whether WMH volume is associated with ADL and cognitive function and whether glucose control and glucose variability can affect WMH volume in these patients. Methods: This cross-sectional study investigated the associations of WMH with cognitive function and instrumental ADL (IADL), as well as metabolic and vascular risk factors in a total of 178 elderly patients with diabetes...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28716257/associations-between-white-matter-hyperintensities-and-cognitive-decline-over-three-years-in-non-dementia-older-adults-with-memory-complaints
#3
So Young Moon, Philipe de Souto Barreto, Marie Chupin, Jean François Mangin, Ali Bouyahia, Ludovic Fillon, Sandrine Andrieu, Bruno Vellas
We investigated whether the baseline level and overtime changes of white matter hyperintensities (WMH) would be associated with cognitive decline over three years in non-demented older adults with memory complaints. 109 participants with baseline magnetic resonance imaging (MRI) and follow-up cognitive assessments up to 3-year were included; among them, 82 also had a follow-up MRI assessment over three years. WMH volume was obtained by an automated segmentation algorithm. Baseline WMH volumes and change between baseline and follow-up WMH were related to cognitive scores over time using mixed-effect linear regressions...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28716089/greater-periventricular-white-matter-hyperintensity-severity-in-basilar-artery-branch-atheromatous-disease
#4
Po-Chen Lin, Feng-Chi Chang, Hui-Chi Huang, Jui-Yao Tsai, Yung-Yang Lin, Chih-Ping Chung
BACKGROUND: Basilar artery branch atheromatous disease (BABAD), in which basilar artery atheroma occludes penetrating arteries at their origin, is a common etiology of posterior circulation stroke (PCS). It is currently unknown whether white matter hyperintensity(WMH), a marker of small vessel disease(SVD), is associated with BABAD. METHODS: The present study analyzed data from patients with PCS who were enrolled in the Taipei Veterans General Hospital Stroke Registry between January 1, 2010 and February 28, 2014...
July 17, 2017: BMC Neurology
https://www.readbyqxmd.com/read/28688824/white-matter-lesions-are-associated-with-specific-depressive-symptom-trajectories-among-incident-depression-and-dementia-populations-three-city-dijon-mri-study
#5
Phillip J Tully, Stephanie Debette, Bernard Mazoyer, Christophe Tzourio
OBJECTIVE: Evidence is mixed as to whether periventricular or deep white matter hyperintensities (WMHs) increase the risk for depressive symptoms, partly because of heterogeneity in depression measurement, short follow-up, and confounding by prodromal dementia. The study objective was to evaluate WMH volume in relation to discrete depressive symptoms over 10 years, stratifying by incident depression and dementia. METHODS: In this prospective longitudinal cohort study of a representative population sample from Dijon, France, 1,440 participants aged 65-80 years (median age: 72 years; 59...
July 5, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28685621/white-matter-hyperintensities-associated-with-small-vessel-disease-impair-social-cognition-beside-attention-and-memory
#6
Jana Kynast, Leonie Lampe, Tobias Luck, Stefan Frisch, Katrin Arelin, Karl-Titus Hoffmann, Markus Loeffler, Steffi G Riedel-Heller, Arno Villringer, Matthias L Schroeter
Age-related white matter hyperintensities (WMH) are a manifestation of white matter damage seen on magnetic resonance imaging (MRI). They are related to vascular risk factors and cognitive impairment. This study investigated the cognitive profile at different stages of WMH in a large community-dwelling sample; 849 subjects aged 21 to 79 years were classified on the 4-stage Fazekas scale according to hyperintense lesions seen on individual T2-weighted fluid-attenuated inversion recovery MRI scans. The evaluation of cognitive functioning included seven domains of cognitive performance and five domains of subjective impairment, as proposed by the DSM-5...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/28676986/incidental-findings-on-cerebral-mri-in-twins-the-older-australian-twins-study
#7
Rebecca Koncz, Adith Mohan, Laughlin Dawes, Anbupalam Thalamuthu, Margaret Wright, David Ames, Teresa Lee, Julian Trollor, Wei Wen, Perminder Sachdev
Incidental findings on structural cerebral magnetic resonance imaging (MRI) are common in healthy subjects, and the prevalence increases with age. There is a paucity of data regarding incidental cerebral findings in twins. We examined brain MRI data acquired from community-dwelling older twins to determine the prevalence and concordance of incidental cerebral findings, as well as the associated clinical implications. Participants (n = 400) were drawn from the Older Australian Twins Study. T1-weighted and T2-weighted fluid-attenuated inversion recovery (FLAIR) cerebral MRI scans were systematically reviewed by a trained, blinded clinician...
July 4, 2017: Brain Imaging and Behavior
https://www.readbyqxmd.com/read/28672181/corpus-callosum-macro-and-microstructure-in-late-life-depression
#8
Louise Emsell, Christopher Adamson, François-Laurent De Winter, Thibo Billiet, Daan Christiaens, Filip Bouckaert, Katarzyna Adamczuk, Rik Vandenberghe, Marc L Seal, Pascal Sienaert, Stefan Sunaert, Mathieu Vandenbulcke
BACKGROUND: Differences in corpus callosum (CC) morphology and microstructure have been implicated in late-life depression and may distinguish between late and early-onset forms of the illness. However, a multimodal approach using complementary imaging techniques is required to disentangle microstructural alterations from macrostructural partial volume effects. METHODS: 107 older adults were assessed: 55 currently-depressed patients without dementia and 52 controls without cognitive impairment...
November 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28659787/better-correlation-of-cognitive-function-to-white-matter-integrity-than-to-blood-supply-in-subjects-with-leukoaraiosis
#9
Genlong Zhong, Ruiting Zhang, Yerfan Jiaerken, Xinfeng Yu, Ying Zhou, Chang Liu, Longting Lin, Lusha Tong, Min Lou
Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged from 43 to 85 years, with mean white matter hyperintensities (WMH) volume 30.69 ± 24.35 mL. Among them, 19(25.33%) subjects presented with cerebral microbleeds (CMB) and 40 (53...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28653212/higher-blood-brain-barrier-permeability-is-associated-with-higher-white-matter-hyperintensities-burden
#10
Yue Li, Man Li, Xiaoyu Zhang, Qinglei Shi, Shuna Yang, Huimin Fan, Wei Qin, Lei Yang, Junliang Yuan, Tao Jiang, Wenli Hu
The pathogenesis of white matter hyperintensities (WMH) is incompletely understood but blood-brain barrier (BBB) dysfunction may play a key role. This study aimed to investigate the relationship between BBB permeability and the severity of WMH burden. Consecutive participants without symptomatic stroke history presented for physical examination were recruited in this cross-sectional study and divided into three WMH burden groups according to total Fazekas scores. They received dynamic contrast-enhanced-magnetic resonance imaging to measure BBB permeability, and received Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)...
July 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28638719/abnormal-amplitude-of-low-frequency-fluctuations-and-functional-connectivity-of-resting-state-functional-magnetic-resonance-imaging-in-patients-with-leukoaraiosis
#11
Rongchuan Cheng, Honglin Qi, Yong Liu, Shifu Zhao, Chuanming Li, Chen Liu, Jian Zheng
INTRODUCTION: This study aimed to investigate the cerebral function deficits in patients with leukoaraiosis (LA) and the correlation with white matter hyperintensity (WMH) using functional MRI (fMRI) technology. MATERIALS AND METHODS: Twenty-eight patients with LA and 30 volunteers were enrolled in this study. All patients underwent structural MRI and resting-state functional MRI (rs-fMRI) scanning. The amplitude of low-frequency fluctuations (ALFF) of rs-fMRI signals for the two groups was compared using two-sample t tests...
June 2017: Brain and Behavior
https://www.readbyqxmd.com/read/28602597/performance-comparison-of-10-different-classification-techniques-in-segmenting-white-matter-hyperintensities-in-aging
#12
Mahsa Dadar, Josefina Maranzano, Karen Misquitta, Cassandra J Anor, Vladimir S Fonov, M Carmela Tartaglia, Owen T Carmichael, Charles Decarli, D Louis Collins
INTRODUCTION: White matter hyperintensities (WMHs) are areas of abnormal signal on magnetic resonance images (MRIs) that characterize various types of histopathological lesions. The load and location of WMHs are important clinical measures that may indicate the presence of small vessel disease in aging and Alzheimer's disease (AD) patients. Manually segmenting WMHs is time consuming and prone to inter-rater and intra-rater variabilities. Automated tools that can accurately and robustly detect these lesions can be used to measure the vascular burden in individuals with AD or the elderly population in general...
June 10, 2017: NeuroImage
https://www.readbyqxmd.com/read/28600458/structural-mri-markers-of-brain-aging-early-after-ischemic-stroke
#13
Emilio Werden, Toby Cumming, Qi Li, Laura Bird, Michele Veldsman, Heath R Pardoe, Graeme Jackson, Geoffrey A Donnan, Amy Brodtmann
OBJECTIVE: To examine associations between ischemic stroke, vascular risk factors, and MRI markers of brain aging. METHODS: Eighty-one patients (mean age 67.5 ± 13.1 years, 31 left-sided, 61 men) with confirmed first-ever (n = 66) or recurrent (n = 15) ischemic stroke underwent 3T MRI scanning within 6 weeks of symptom onset (mean 26 ± 9 days). Age-matched controls (n = 40) completed identical testing. Multivariate regression analyses examined associations between group membership and MRI markers of brain aging (cortical thickness, total brain volume, white matter hyperintensity [WMH] volume, hippocampal volume), normalized against intracranial volume, and the effects of vascular risk factors on these relationships...
July 11, 2017: Neurology
https://www.readbyqxmd.com/read/28600443/prevalence-risk-factors-and-consequences-of-cerebral-small-vessel-diseases-data-from-three-asian-countries
#14
Saima Hilal, Vincent Mok, Young Chul Youn, Adrian Wong, Mohammad Kamran Ikram, Christopher Li-Hsian Chen
BACKGROUND: Cerebral small vessel disease (SVD) has been suggested to be more common in Asians compared with Caucasians. However, data from population-based studies in Asia are lacking. We report on the prevalence, risk factors and consequences of SVD from contemporary studies in three Asian countries using 3-Tesla MRI for the evaluation of SVD. METHODS: Clinical, cognitive and 3-Tesla brain MRI assessments were performed among participants of three studies from Singapore, Hong Kong and Korea...
August 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28596452/effect-of-long-term-vascular-care-on-progression-of-cerebrovascular-lesions-magnetic-resonance-imaging-substudy-of-the-prediva-trial-prevention-of-dementia-by-intensive-vascular-care
#15
Jan Willem van Dalen, Eric P Moll van Charante, Matthan W A Caan, Philip Scheltens, Charles B L M Majoie, Aart J Nederveen, Willem A van Gool, Edo Richard
BACKGROUND AND PURPOSE: This study aimed to evaluate the effect of a nurse-led multidomain cardiovascular intervention on white matter hyperintensity (WMH) progression and incident lacunar infarcts in community-dwelling elderly with hypertension. METHODS: The preDIVA trial (Prevention of Dementia by Intensive Vascular Care) was an open-label, cluster-randomized controlled trial in community-dwelling individuals aged 70 to 78 years. General practices were assigned by computer-generated randomization to 6-year nurse-led, multidomain intensive vascular care or standard care...
June 8, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28588075/cerebral-perfusion-and-the-risk-of-dementia-a-population-based-study
#16
Frank J Wolters, Hazel I Zonneveld, Albert Hofman, Aad van der Lugt, Peter J Koudstaal, Meike W Vernooij, M Arfan Ikram
Background -Cerebral hypoperfusion has previously been associated with mild cognitive impairment and dementia in various cross-sectional studies, but whether hypoperfusion precedes neurodegeneration is unknown. We prospectively determined the association of cerebral perfusion with subsequent cognitive decline and development of dementia. Methods -Between 2005 and 2012, we measured cerebral blood flow by 2D phase-contrast magnetic resonance imaging (MRI) in non-demented participants of the population-based Rotterdam Study...
June 6, 2017: Circulation
https://www.readbyqxmd.com/read/28574812/associations-between-apoe-genotype-and-cerebral-small-vessel-disease-a-longitudinal-study
#17
Xiao Luo, Yerfan Jiaerken, Xinfeng Yu, Peiyu Huang, Tiantian Qiu, Yunlu Jia, Kaicheng Li, Xiaojun Xu, Zhujing Shen, Xiaojun Guan, Jiong Zhou, Minming Zhang, For The Alzheimer's Disease Neuroimaging Initiative Adni
OBJECTIVE: It remains unclear if and how the interactions between APOE genotypes and cerebral small-vessel diseases (CSVD) lead to cognitive decline in the long term. Based on ADNI cohort, this longitudinal study aimed to clarify the potential relationship among APOE genotype, CSVD and cognition by integrating multi-level data. METHOD: There were 135 healthy elderly (including ε2, ε4 allele carriers and ε3 homozygotes) who had completed two years' follow-up. MRI markers of CSVD, including white matter hyperintensities (WMH), dilated perivascular space (dPVS), microbleeds and lacune, were assessed...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28574155/a-systematic-review-of-neuroimaging-in-delirium-predictors-correlates-and-consequences
#18
Anita Nitchingham, Varun Kumar, Susan Shenkin, Karen J Ferguson, Gideon A Caplan
OBJECTIVE: Neuroimaging advances our understanding of delirium pathophysiology and its consequences. A previous systematic review identified 12 studies (total participants N = 764, delirium cases N = 194; years 1989-2007) and found associations with white matter hyperintensities (WMH) and cerebral atrophy. Our objectives were to perform an updated systematic review of neuroimaging studies in delirium published since January 2006 and summarise the available literature on predictors, correlates or outcomes...
June 2, 2017: International Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28566448/disease-progression-and-regression-in-sporadic-small-vessel-disease-insights-from-neuroimaging
#19
REVIEW
Esther M C van Leijsen, Frank-Erik de Leeuw, Anil M Tuladhar
Cerebral small vessel disease (SVD) is considered the most important vascular contributor to the development of dementia. Comprehensive characterization of the time course of disease progression will result in better understanding of aetiology and clinical consequences of SVD. SVD progression has been studied extensively over the years, usually describing change in SVD markers over time using neuroimaging at two time points. As a consequence, SVD is usually seen as a rather linear, continuously progressive process...
June 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28554961/atrial-fibrillation-is-associated-with-anterior-predominant-white-matter-lesions-in-patients-presenting-with-embolic-stroke
#20
Yunis Mayasi, Johanna Helenius, David D McManus, Richard P Goddeau, Adalia H Jun-O'Connell, Majaz Moonis, Nils Henninger
OBJECTIVE: High white matter hyperintensity (WMH) burden is commonly found on brain MRI among patients with atrial fibrillation (AF). However, whether the link between AF and WMH extends beyond a common vascular risk factor profile is uncertain. We sought to determine whether AF relates to a distinct WMH lesion pattern which may suggest specific underlying pathophysiological relationships. METHODS: We retrospectively analysed a cohort of consecutive patients presenting with embolic stroke at an academic hospital and tertiary referral centre between March 2010 and March 2014...
May 27, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
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