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https://www.readbyqxmd.com/read/29139161/cognitive-abilities-brain-white-matter-hyperintensity-volume-and-structural-network-connectivity-in-older-age
#1
Stewart J Wiseman, Tom Booth, Stuart J Ritchie, Simon R Cox, Susana Muñoz Maniega, Maria Del C Valdés Hernández, David Alexander Dickie, Natalie A Royle, John M Starr, Ian J Deary, Joanna M Wardlaw, Mark E Bastin
OBJECTIVE: To assess brain structural connectivity in relation to cognitive abilities in healthy ageing, and the mediating effects of white matter hyper-intensity (WMH) volume. METHODS: MRI data were analysed in 558 members of the Lothian Birth Cohort 1936. Brains were segmented into 85 regions and combined with tractography to generate structural connectomes. WMH volume was quantified. Relationships between whole-brain connectivity, assessed using graph theory metrics, and four major domains of cognitive ability (visuospatial reasoning, verbal memory, information processing speed and crystallized ability) were investigated, as was the mediating effects of WMH volume on these relationships...
November 14, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/29132940/bullseye-s-representation-of-cerebral-white-matter-hyperintensities
#2
Carole H Sudre, Beatriz Gomez Anson, Indran Davagnanamd, Anne Schmitt, Alex F Mendelson, Ferran Prados, Lorna Smith, David Atkinson, Alun David Hughes, Nish Chaturvedi, M Jorge Cardoso, Frederik Barkhof, Hans Rolf Jaeger, Sébastien Ourselin
BACKGROUND AND PURPOSE: Visual rating scales have limited capacities to depict the regional distribution of cerebral white matter hyperintensities (WMH). We present a regional-zonal volumetric analysis alongside a visualization tool to compare and deconstruct visual rating scales. MATERIALS AND METHODS: 3D T1-weighted, T2-weighted spin-echo and FLAIR images were acquired on a 3T system, from 82 elderly participants in a population-based study. Images were automatically segmented for WMH...
November 10, 2017: Journal of Neuroradiology. Journal de Neuroradiologie
https://www.readbyqxmd.com/read/29119266/civilians-in-world-war-ii-and-dsm-iv-mental-disorders-results-from-the-world-mental-health-survey-initiative
#3
Rochelle Frounfelker, Stephen E Gilman, Theresa S Betancourt, Sergio Aguilar-Gaxiola, Jordi Alonso, Evelyn J Bromet, Ronny Bruffaerts, Giovanni de Girolamo, Semyon Gluzman, Oye Gureje, Elie G Karam, Sing Lee, Jean-Pierre Lépine, Yutaka Ono, Beth-Ellen Pennell, Daniela G Popovici, Margreet Ten Have, Ronald C Kessler
PURPOSE: Understanding the effects of war on mental disorders is important for developing effective post-conflict recovery policies and programs. The current study uses cross-sectional, retrospectively reported data collected as part of the World Mental Health (WMH) Survey Initiative to examine the associations of being a civilian in a war zone/region of terror in World War II with a range of DSM-IV mental disorders. METHODS: Adults (n = 3370) who lived in countries directly involved in World War II in Europe and Japan were administered structured diagnostic interviews of lifetime DSM-IV mental disorders...
November 8, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/29115734/more-extensive-white-matter-hyperintensity-is-linked-with-higher-risk-of-remote-intracerebral-hemorrhage-after-intravenous-thrombolysis
#4
Yi Chen, Shenqiang Yan, Mengjun Xu, Genlong Zhong, David S Liebeskind, Min Lou
BACKGROUND AND PURPOSES: Remote intracerebral hemorrhage (rICH) is infrequent after intravenous thrombolysis (IVT) and its mechanism remains poorly understood. We aim to assess its frequency and possible relationship with the severity of white matter hyperintensity (WMH) in acute ischemic stroke (AIS) patients. METHODS: We prospectively analyzed data from consecutive AIS patients with MRI and IVT. WMH volume was quantitatively measured. rICH was defined as intracranial hemorrhage that appears in brain regions without visible ischemic changes on 24h follow-up imaging...
November 8, 2017: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/29114731/association-of-cardiac-hemodynamic-factors-with-severity-of-white-matter-hyperintensities-in-chronic-valvular-heart-disease
#5
Woo-Jin Lee, Keun-Hwa Jung, Young Jin Ryu, Jeong-Min Kim, Soon-Tae Lee, Kon Chu, Manho Kim, Sang Kun Lee, Jae-Kyu Roh
Importance: The cerebral white matter hyperintensity (WMH) is frequently noted in patients with chronic heart disease. Long-term alteration of cardiac hemodynamics might have an influence on the mechanism of cerebral WMH. Objective: To investigate the association between chronically altered cardiac hemodynamics and severity of cerebral WMH in patients with chronic valvular heart disease. Design, Setting, and Participants: This cross-sectional analysis identified 303 consecutive patients at a tertiary referral center between 2008 and 2016 who were 50 years or older, and diagnosed with severe chronic valvular heart disease and underwent cardiac catherization, echocardiography, and received brain magnetic resonance imaging...
November 6, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/29110998/total-small-vessel-disease-burden-and-brain-network-efficiency-in-cerebral-amyloid-angiopathy
#6
Raffaella Valenti, Yael D Reijmer, Andreas Charidimou, Gregoire Boulouis, Sergi Ramirez Martinez, Li Xiong, Panagiotis Fotiadis, Michael Jessel, Alison Ayres, Grace Riley, Leonardo Pantoni, M Edip Gurol, Steven M Greenberg, Anand Viswanathan
BACKGROUND: Cerebral amyloid angiopathy (CAA) is associated with hemorrhagic and nonhemorrhagic markers small vessel disease (SVD). A composite score to quantify the total burden of SVD on MRI specifically for CAA patients was recently developed. Brain network alterations related to individual MRI markers of SVD in CAA were demonstrated. OBJECTIVES: Considering diffusion based network measures sensitive to detect different relevant SVD-related brain injury, we investigated if increased overall SVD injury on MRI corresponds to worse global brain connectivity in CAA...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29106439/increased-diastolic-blood-pressure-is-associated-with-mri-biomarkers-of-dementia-related-brain-pathology-in-normative-ageing
#7
Christopher J McNeil, Phyo Kyaw Myint, Anca-Larisa Sandu, John F Potter, Roger Staff, Lawrence J Whalley, Alison D Murray
Background: hypertension is a risk for brain ageing, but the mechanisms underlying this effect remain unclear. Magnetic resonance imaging (MRI) detected biomarkers of brain ageing include white matter hyperintensities (WMHs), a marker of cerebrovascular disease, and hippocampal volume, a marker of Alzheimer's disease pathology. Objective: to examine relationships between blood pressure (BP) components and brain pathology in older adults. Subjects: two hundred and twenty-seven members of the Aberdeen 1936 Birth Cohort between ages 64 and 68 years...
July 4, 2017: Age and Ageing
https://www.readbyqxmd.com/read/29106319/lesion-location-matters-the-relationships-between-white-matter-hyperintensities-on-cognition-in-the-healthy-elderly
#8
Leonie Lampe, Shahrzad Kharabian-Masouleh, Jana Kynast, Katrin Arelin, Christopher J Steele, Markus Löffler, A Veronica Witte, Matthias L Schroeter, Arno Villringer, Pierre-Louis Bazin
White matter hyperintensities (WMH) are associated with cognitive decline. We aimed to identify the spatial specificity of WMH impact on cognition in non-demented, healthy elderly. We quantified WMH volume among healthy participants of a community dwelling cohort ( n = 702, age range 60 - 82 years, mean age = 69.5 years, 46% female) and investigated the effects of WMH on cognition and behavior, specifically for executive function, memory, and motor speed performance. Lesion location influenced their effect on cognition and behavior: Frontal WMH in the proximity of the frontal ventricles mainly affected executive function and parieto-temporal WMH in the proximity of the posterior horns deteriorated memory, while WMH in the upper deep white matter-including the corticospinal tract-compromised motor speed performance...
January 1, 2017: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29100854/white-matter-hyperintensity-associated-blood-brain-barrier-disruption-and-vascular-risk-factors
#9
Nidhi Gupta, Alexis N Simpkins, Emi Hitomi, Christian Dias, Richard Leigh
BACKGROUND: White matter hyperintensities (WMH), the hallmark of vascular cognitive impairment, are associated with vascular risk factors (VRF). WMH can also be associated with blood-brain barrier (BBB) disruption. The purpose of this study was to look for associations between VRF and BBB disruption in stroke patients with WMH. METHODS: Magnetic resonance images of stroke patients were reviewed for the presence of WMH. Blood-brain permeability images were retrospectively generated...
October 31, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29096697/race-modifies-the-relationship-between-cognition-and-alzheimer-s-disease-cerebrospinal-fluid-biomarkers
#10
Jennifer C Howell, Kelly D Watts, Monica W Parker, Junjie Wu, Alexander Kollhoff, Thomas S Wingo, Cornelya D Dorbin, Deqiang Qiu, William T Hu
BACKGROUND: African Americans have been reported to have a higher prevalence of Alzheimer's disease (AD) than Caucasians, but etiology-specific AD biomarkers have not been systematically analyzed in older African Americans. Coexisting cerebrovascular disease may also contribute to this increased prevalence. We hypothesized that cerebrospinal fluid (CSF) biomarkers of amyloid, neurodegeneration, and endothelial dysfunction would differ between older African Americans and Caucasians with normal cognition and cognitive impairment associated with AD...
November 2, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29080050/development-of-a-women-s-mental-health-curriculum-and-evolution-to-a-women-s-mental-health-area-of-concentration-in-a-psychiatry-residency-program
#11
Priya Gopalan, Jody Glance, Robin Valpey, Heather Joseph, Neeta Shenai
In 2014, the U.S. Department of Health and Human Services' Office on Women's Health emphasized the importance of women's health education, particularly in the realm of behavioral health. In order to support the professional interests of psychiatry trainees, a women's mental health study group (WMHSG) was developed and implemented. The WMHSG aimed primarily to supplement the resident curriculum and promote consideration of careers in women's mental health. After successful implementation, the curriculum was formalized into a Women's Mental Health Area of Concentration within the Department of Psychiatry's residency training program...
October 27, 2017: Archives of Women's Mental Health
https://www.readbyqxmd.com/read/29079684/spaceflight-induced-changes-in-white-matter-hyperintensity-burden-in-astronauts
#12
Noam Alperin, Ahmet M Bagci, Sang H Lee
OBJECTIVE: To assess the effect of weightlessness and the respective roles of CSF and vascular fluid on changes in white matter hyperintensity (WMH) burden in astronauts. METHODS: We analyzed prespaceflight and postspaceflight brain MRI scans from 17 astronauts, 10 who flew a long-duration mission on the International Space Station (ISS) and 7 who flew a short-duration mission on the Space Shuttle. Automated analysis methods were used to determine preflight to postflight changes in periventricular and deep WMH, CSF, and brain tissue volumes in fluid-attenuated inversion recovery and high-resolution 3-dimensional T1-weighted imaging...
October 27, 2017: Neurology
https://www.readbyqxmd.com/read/29075426/trauma-and-ptsd-in-the-who-world-mental-health-surveys
#13
Ronald C Kessler, Sergio Aguilar-Gaxiola, Jordi Alonso, Corina Benjet, Evelyn J Bromet, Graça Cardoso, Louisa Degenhardt, Giovanni de Girolamo, Rumyana V Dinolova, Finola Ferry, Silvia Florescu, Oye Gureje, Josep Maria Haro, Yueqin Huang, Elie G Karam, Norito Kawakami, Sing Lee, Jean-Pierre Lepine, Daphna Levinson, Fernando Navarro-Mateu, Beth-Ellen Pennell, Marina Piazza, José Posada-Villa, Kate M Scott, Dan J Stein, Margreet Ten Have, Yolanda Torres, Maria Carmen Viana, Maria V Petukhova, Nancy A Sampson, Alan M Zaslavsky, Karestan C Koenen
Background: Although post-traumatic stress disorder (PTSD) onset-persistence is thought to vary significantly by trauma type, most epidemiological surveys are incapable of assessing this because they evaluate lifetime PTSD only for traumas nominated by respondents as their 'worst.' Objective: To review research on associations of trauma type with PTSD in the WHO World Mental Health (WMH) surveys, a series of epidemiological surveys that obtained representative data on trauma-specific PTSD. Method: WMH Surveys in 24 countries (n = 68,894) assessed 29 lifetime traumas and evaluated PTSD twice for each respondent: once for the 'worst' lifetime trauma and separately for a randomly-selected trauma with weighting to adjust for individual differences in trauma exposures...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/29069180/work-related-mental-health-surveillance-in-brazil-characteristics-difficulties-and-challenges
#14
Tania Maria Araújo, Tarciso de Figueiredo Palma, Natália do Carmo Araújo
This paper addresses the challenges and difficulties in Work-related Mental Health (WMH) Surveillance in Brazil, based on a review of the bibliographic literature. From the compilation of identified academic research, it seeks to foster reflections about the current landscape of surveillance actions, its main obstacles, and possibilities for improvement. A survey of national publications was carried out using Scielo, Lilacs and PUBMED databases from 2002 until 2017. Systematizing the results allows us to group the following themes: Epidemiology of WMH in Brazil; Policies for WMH and VISAT; Work Environment for Mental Health; and, Actions and Interventions in the VISAT and WMH...
October 2017: Ciência & Saúde Coletiva
https://www.readbyqxmd.com/read/29061091/exploring-the-spectrum-of-subcortical-hyperintensities-and-cognitive-decline
#15
Yi-Chun Chen, Hsien-Hao Tsao, Yi-Chuan Chu, Jiun-Jie Wang, Jiann-Der Lee, Pi-Yueh Chang, Wen-Chuin Hsu
White matter hyperintensities (WMHs) include periventricular WMH (pvWMH) and deep WMH. When hyperintensities in the basal ganglia or brainstem are included, the collective term is subcortical hyperintensities. Both WMH and medial temporal lobe atrophy (MTA) are risk factors for cognitive decline. This prospective study enrolled participants aged 50-85 years and followed their neuropsychological assessments annually for 2 years to explore the interactive effects of WMH and MTA on longitudinal clinical decline...
October 24, 2017: Journal of Neuropsychiatry and Clinical Neurosciences
https://www.readbyqxmd.com/read/29046363/serum-neurofilament-light-is-sensitive-to-active-cerebral-small-vessel-disease
#16
Thomas Gattringer, Daniela Pinter, Christian Enzinger, Thomas Seifert-Held, Markus Kneihsl, Simon Fandler, Alexander Pichler, Christian Barro, Svenya Gröbke, Margarete Voortman, Lukas Pirpamer, Edith Hofer, Stefan Ropele, Reinhold Schmidt, Jens Kuhle, Franz Fazekas, Michael Khalil
OBJECTIVE: To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and to determine the subsequent course and determinants of NfL levels in a longitudinal manner. METHODS: In a prospectively collected group of symptomatic patients with an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI and serum NfL using a Single Molecule Array (Simoa) assay at baseline and at 3 and 15 months after stroke...
October 18, 2017: Neurology
https://www.readbyqxmd.com/read/29046152/cerebral-small-vessel-disease-is-associated-with-genetic-variations-in-cyp2j
#17
Ming Yao, Daping Lv, Jiajia Huo, Zhongwu Sun
BACKGROUND: Cerebral small vessel disease (SVD) can cause cognitive impairment, disability, and dementia. While it's still unclear about the pathogenesis of SVD, several risk factors of SVD have been identified, and studies suggested that hypertension may play a critical role in SVD. Furthermore, studies have demonstrated that CYP2J2 isoform, 50 G>T variant, is associated with increase the risk of ischemic stroke. Thus, we hypothesized that CYP2J2 50 G>T variant is associated with increased risk of cerebral SVD...
October 17, 2017: Current Neurovascular Research
https://www.readbyqxmd.com/read/29042572/diagonal-earlobe-crease-is-a-visible-sign-for-cerebral-small-vessel-disease-and-amyloid-%C3%AE
#18
Jin San Lee, Seongbeom Park, Hee Jin Kim, Yeshin Kim, Hyemin Jang, Ko Woon Kim, Hak Young Rhee, Sung Sang Yoon, Kyoung Jin Hwang, Key-Chung Park, Seung Hwan Moon, Sung Tae Kim, Samuel N Lockhart, Duk L Na, Sang Won Seo
We investigated the frequency and clinical significance of diagonal earlobe crease (DELC) in cognitively impaired patients using imaging biomarkers, such as white matter hyperintensities (WMH) on MRI and amyloid-β (Aβ) PET. A total of 471 cognitively impaired patients and 243 cognitively normal (CN) individuals were included in this study. Compared with CN individuals, cognitively impaired patients had a greater frequency of DELC (OR 1.6, 95% CI 1.1-2.2, P = 0.007). This relationship was more prominent in patients with dementia (OR 1...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29021757/cerebral-small-vessel-disease-burden-is-associated-with-motor-performance-of-lower-and-upper-extremities-in-community-dwelling-populations
#19
Ning Su, Fei-Fei Zhai, Li-Xin Zhou, Jun Ni, Ming Yao, Ming-Li Li, Zheng-Yu Jin, Gao-Lang Gong, Shu-Yang Zhang, Li-Ying Cui, Feng Tian, Yi-Cheng Zhu
Objective: To investigate the correlation between cerebral small vessel disease (CSVD) burden and motor performance of lower and upper extremities in community-dwelling populations. Methods: We performed a cross-sectional analysis on 770 participants enrolled in the Shunyi study, which is a population-based cohort study. CSVD burden, including white matter hyperintensities (WMH), lacunes, cerebral microbleeds (CMBs), perivascular spaces (PVS), and brain atrophy were measured using 3T magnetic resonance imaging...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29019366/moderation-of-hyperuricemia-in-rats-via-consuming-walnut-protein-hydrolysate-diet-and-identification-of-new-antihyperuricemic-peptides
#20
Qingyong Li, Xiaoyan Kang, Chuanchao Shi, Yujuan Li, Kaustav Majumder, Zhengxiang Ning, Jiaoyan Ren
In this study, walnut meal hydrolysates (WMH) and dephenolized walnut meal hydrolysates (DWMH) were found to effectively decrease the serum uric acid level and protect the renal function in potassium oxonate-induced hyperuricemic rats in vivo as well as inhibit xanthine oxidase in vitro. Two novel antihyperuricemic peptides including WPPKN (640.8 Da) and ADIYTE (710.7 Da) were purified from DWMH via Sephadex G-15 gel filtration and reverse-phase high-performance liquid chromatography and identified by LC-ESI-MS/MS...
October 11, 2017: Food & Function
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