keyword
MENU ▼
Read by QxMD icon Read
search

Silent Cerebral Infarction

keyword
https://www.readbyqxmd.com/read/29120564/developmental-venous-anomaly-serving-as-a-draining-vein-of-brain-arteriovenous-malformation
#1
Lukas Rasulić, Filip Vitošević, Krešimir Rotim, Svetlana Milošević Medenica, Dragoslav Nestorović
Developmental venous anomalies are cerebral vascular malformations that present normal venous drainage of cerebral tissue. With increased and accessible usage of modern diagnostic tools, they are now one of the most commonly diagnosed cerebral vascular malformations. Although developmental venous anomalies are considered to be benign lesions, association with arteriovenous malformation renders malignant potential to this combined pathology. In the case presented, these malformations were clinically silent and diagnosed accidentally, so they were not treated either with surgery, endovascular surgery or radiosurgery, considering the possible complications such as venous infarction of the brain, and because there was no obvious neurologic deficit related to this pathology...
March 2017: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29107441/real-life-experience-with-hydroxyurea-in-sickle-cell-disease-a-multicenter-study-in-a-cohort-of-patients-with-heterogeneous-descent
#2
Paolo Rigano, Lucia De Franceschi, Laura Sainati, Antonio Piga, Frédéric B Piel, Maria Domenica Cappellini, Carmelo Fidone, Nicoletta Masera, Giovanni Palazzi, Barbara Gianesin, Gian Luca Forni
We conducted the first nation-wide cohort study of sickle cell disease (SCD) in Italy, a Southern European country exposed to intense recent flux migration from endemic areas for SCD. We evaluate the impact of hydroxyurea on a total of 652 pediatric and adult patients from 33 Reference Centers for SCD (mean age 24.5±15years, 51.4% males). Hydroxyurea median treatment duration was 7years (range: <1year to 29years) at a mean therapeutic dose of 18±4.7mg/kg/day. Hydroxyurea was associated with a significant increase in mean total and fetal hemoglobin and a significant decrease in mean hemoglobin S, white blood and platelet counts, and lactate dehydrogenase levels...
October 9, 2017: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/29061396/increased-level-of-procalcitonin-is-associated-with-total-mri-burden-of-cerebral-small-vessel-disease-in-patients-with-ischemic-stroke
#3
Guangzong Li, Chen Zhu, Jing Li, Xiangming Wang, Qingbin Zhang, Hongjia Zheng, Cheng Zhan
BACKGROUND: Procalcitonin (PCT) has been found to be associated with subclinical cerebrovascular damage. The relationship between PCT levels and cerebral small vessel disease (cSVD), especially cSVD burden, has not been fully understood. This study aimed to investigate the association between PCT levels and cSVD in patients with first-ever acute ischemic stroke or transient ischemic attack (TIA). METHODS: Two hundred and seventy-eight consecutive patients were prospectively recruited during Jan 2016 to Jun 2017...
October 20, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29046363/serum-neurofilament-light-is-sensitive-to-active-cerebral-small-vessel-disease
#4
Thomas Gattringer, Daniela Pinter, Christian Enzinger, Thomas Seifert-Held, Markus Kneihsl, Simon Fandler, Alexander Pichler, Christian Barro, Svenya Gröbke, Margarete Voortman, Lukas Pirpamer, Edith Hofer, Stefan Ropele, Reinhold Schmidt, Jens Kuhle, Franz Fazekas, Michael Khalil
OBJECTIVE: To explore whether serum neurofilament light chain protein (NfL) levels are increased in patients with MRI-confirmed recent small subcortical infarcts (RSSI) compared to healthy controls and to determine the subsequent course and determinants of NfL levels in a longitudinal manner. METHODS: In a prospectively collected group of symptomatic patients with an RSSI (n = 79, mean age 61 ± 11 years, 67% male), we analyzed brain MRI and serum NfL using a Single Molecule Array (Simoa) assay at baseline and at 3 and 15 months after stroke...
October 18, 2017: Neurology
https://www.readbyqxmd.com/read/29018134/neuronal-sirt1-silent-information-regulator-2-homologue-1-regulates-glycolysis-and-mediates-resveratrol-induced-ischemic-tolerance
#5
Kevin B Koronowski, Nathalie Khoury, Isabel Saul, Zachary B Loris, Charles H Cohan, Holly M Stradecki-Cohan, Kunjan R Dave, Juan I Young, Miguel A Perez-Pinzon
BACKGROUND AND PURPOSE: Resveratrol, at least in part via SIRT1 (silent information regulator 2 homologue 1) activation, protects against cerebral ischemia when administered 2 days before injury. However, it remains unclear if SIRT1 activation must occur, and in which brain cell types, for the induction of neuroprotection. We hypothesized that neuronal SIRT1 is essential for resveratrol-induced ischemic tolerance and sought to characterize the metabolic pathways regulated by neuronal Sirt1 at the cellular level in the brain...
November 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28983720/symptomatic-and-silent-cerebral-infarction-following-surgical-clipping-of-unruptured-intracranial-aneurysms-incidence-risk-factors-and-clinical-outcome
#6
Maogui Li, Jun Wu, Xin Chen, Pengjun Jiang, Fan Yang, Yonggang Ma, Zhengsong Li, Yong Cao, Shuo Wang
Cerebral infarction (CI) associated with clipping of unruptured intracranial aneurysms (UIAs) has not been completely studied. The role of individual and operative characteristics is not known, and the risk of silent CI has not been well described. To determine the incidence, risk factors, and clinical outcome of postoperative CI, we retrospectively analyzed 388 consecutive patients undergoing clipping of UIAs between January 2012 and December 2015. We reviewed the pre- and postoperative computed tomography (CT) images of each patient...
October 5, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28899518/relationship-between-obstructive-sleep-apnea-and-neuroimaging-signatures-of-cerebral-small-vessel-disease-in-community-dwelling-older-adults-the-atahualpa-project
#7
Oscar H Del Brutto, Robertino M Mera, Mauricio Zambrano, Pablo R Castillo
BACKGROUND/OBJECTIVES: Evidence of a relationship between obstructive sleep apnea (OSA) and neuroimaging signatures of cerebral small vessel disease (SVD) is limited. The present study aimed to evaluate this association in older adults living in rural Ecuador, where small vessel disease is a major pathogenetic mechanism underlying stroke. METHODS: A representative random sample of Atahualpa residents aged ≥60 years enrolled in the Atahualpa Project neuroimaging substudy underwent a single-night diagnostic polysomnography...
September 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28888980/arctigenin-attenuates-ischemic-stroke-via-sirt1-dependent-inhibition-of-nlrp3-inflammasome
#8
Shimeng Zhang, Liangjun Jiang, Fengyuan Che, Yucheng Lu, Zhongxiang Xie, Hao Wang
Arctigenin (ARC), a phenylpropanoid dibenzylbutyrolactone lignan derived from Arctium lappa L, has been reported to protect against cerebral ischemia injury in rats, but the underlying mechanism is unclear. In this study, we investigated whether ARC ameliorated ischemic stroke by inhibiting NLRP3 inflammasome-derived neuroinflammation and whether SIRT1 signaling was involved in this process. ARC (20 mg/kg) or vehicle were intraperitoneally injected to Sprague-Dawley rats for 3 days before middle cerebral artery occlusion (MCAO) surgery performed...
November 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28870552/high-neutrophil-to-lymphocyte-ratio-is-associated-with-white-matter-hyperintensity-in-a-healthy-population
#9
Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Sang Hyuck Kim, Su-Min Jeong, Tae Gon Yoo, Shinhye Kim
High neutrophil to lymphocyte ratio (NLR) is correlated with the occurrence, morbidity and mortality of cerebrovascular disease as a marker of systemic inflammation. However, its effect on cerebral white matter hyperintensity (WMH) is unclear. We investigated high NLR burden as a surrogate marker of WMH volume in a healthy population. Healthy subjects with voluntary health check-ups between January 2006 and December 2013, including brain MRI and laboratory examination, were collected. WMH volumes were rated quantitatively...
September 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28864674/neurologic-complications-of-sickle-cell-disease-in-africa-a-systematic-review-and-meta-analysis
#10
REVIEW
Jean Jacques Noubiap, Michel K Mengnjo, Nicolas Nicastro, Joseph Kamtchum-Tatuene
OBJECTIVE: To summarize prevalence data on the neurologic complications of sickle cell disease (SCD) in Africa. METHODS: We searched EMBASE, PubMed, and African Index Medicus to identify all relevant articles published from inception to May 31, 2016. Each study was reviewed for methodologic quality. A random-effects model was used to estimate the prevalence of neurologic complications of SCD across studies. RESULTS: Thirty-one studies were included...
October 3, 2017: Neurology
https://www.readbyqxmd.com/read/28855432/prospective-study-on-the-incidence-of-cerebrovascular-disease-after-coronary-angiography
#11
Akihiro Tokushige, Masaaki Miyata, Takeshi Sonoda, Ippei Kosedo, Daisuke Kanda, Takuro Takumi, Yuichi Kumagae, Yoshihiko Fukukura, Mitsuru Ohishi
AIM: Previous studies have reported a 10.2%-22% rate of silent cerebral infarction and a 0.1%-1% rate of symptomatic cerebral infarction after coronary angiography (CAG). However, the risk factors of cerebral infarction after CAG have not been fully elucidated. For this reason, we investigated the incidence and risk factors of CVD complications within 48 h after CAG using magnetic resonance imaging (MRI) (Diffusion-weighted MRI) at Kagoshima University Hospital. METHODS: From September 2013 to April 2015, we examined the incidence and risk factors, including procedural data and patients characteristics, of cerebrovascular disease after CAG in consecutive 61 patients who underwent CAG and MRI in our hospital...
August 30, 2017: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/28834316/history-of-parvovirus-b19-infection-is-associated-with-silent-cerebral-infarcts
#12
Foluso J Ogunsile, Kelli L Currie, Mark Rodeghier, Adetola Kassim, Michael R DeBaun, Deva Sharma
BACKGROUND: The relationship between silent cerebral infarcts (SCIs) and history of parvovirus B19 (B19V) has not been systematically evaluated. As an ancillary study from the Silent Cerebral Infarct Trial (SIT) (NCT00072761), we tested the hypothesis that a history of B19V infection is associated with an increased prevalence of SCIs in children with sickle cell anemia. PROCEDURE: We used a retrospective cross-sectional cohort study design; each participant underwent a brain magnetic resonance imaging (MRI) scan and medical record review for prior B19V infection (n = 958)...
August 17, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28821470/design-of-the-drepagreffe-trial-a-prospective-controlled-multicenter-study-evaluating-the-benefit-of-genoidentical-hematopoietic-stem-cell-transplantation-over-chronic-transfusion-in-sickle-cell-anemia-children-detected-to-be-at-risk-of-stroke-by-transcranial
#13
Sylvie Chevret, Suzanne Verlhac, Elisabeth Ducros-Miralles, Jean-Hugues Dalle, Regis Peffault de Latour, Mariane de Montalembert, Malika Benkerrou, Corinne Pondarré, Isabelle Thuret, Corinne Guitton, Emmanuelle Lesprit, Maryse Etienne-Julan, Gisèle Elana, Jean-Pierre Vannier, Patrick Lutz, Bénédicte Neven, Claire Galambrun, Catherine Paillard, Camille Runel, Charlotte Jubert, Cécile Arnaud, Annie Kamdem, Valentine Brousse, Florence Missud, Marie Petras, Lydia Doumdo-Divialle, Claire Berger, Françoise Fréard, Olivier Taieb, Elise Drain, Monique Elmaleh, Manuela Vasile, Yacine Khelif, Myriam Bernaudin, Philippe Chadebech, France Pirenne, Gérard Socié, Françoise Bernaudin
BACKGROUND: Children with sickle cell anemia (SCA) have an 11% risk of stroke by the age of 18. Chronic transfusion applied in patients detected to be at risk by transcranial Doppler allows a significant reduction of stroke risk. However, chronic transfusion exposes to several adverse events, including alloimmunization and iron overload, and is not curative. Hematopoietic stem cell transplantation allows termination of the transfusion program, but its benefit has not been demonstrated...
November 2017: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/28757483/association-of-blood-pressure-control-level-with-left-ventricular-morphology-and-function-and-with-subclinical-cerebrovascular-disease
#14
Koki Nakanishi, Zhezhen Jin, Shunichi Homma, Mitchell S V Elkind, Tatjana Rundek, Aylin Tugcu, Ralph L Sacco, Marco R Di Tullio
BACKGROUND: Left ventricular (LV) hypertrophy and subclinical cerebrovascular disease are early manifestations of cardiac and brain target organ damage caused by hypertension. This study aimed to investigate whether intensive office systolic blood pressure (SBP) control has beneficial effects on LV morphology and function and subclinical cerebrovascular disease in elderly patients with hypertension. METHODS AND RESULTS: We examined 420 patients treated for hypertension without history of heart failure and stroke from the CABL (Cardiovascular Abnormalities and Brain Lesions) study...
July 30, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28716287/kidney-dysfunction-and-silent-brain-infarction-in-generally-healthy-adults
#15
Sang Hyuck Kim, Dong Wook Shin, Jae Moon Yun, Ji Eun Lee, Jae-Sung Lim, Be Long Cho, Hyung-Min Kwon, Jin-Ho Park
BACKGROUND: The association between silent brain infarction (SBI) and estimated glomerular filtration rate (eGFR)-based kidney dysfunction has not yet been definitively confirmed. This study aimed to investigate the association in generally healthy adults without a previous history of stroke or overt kidney disease. METHODS: The data from the screening health check-up program in the Seoul National University Hospital Health Promotion Center from January 1, 2009 to December 31, 2013 were used...
August 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28704853/rbp4-lp-pla2-netrin-1-signaling-regulation-of-cognitive-dysfunction-in-diabetic-nephropathy-complicated-with-silent-cerebral-infarction
#16
Danyan Chen, Xiaolong Huang, Song Lu, Huacong Deng, Hua Gan, Xiaogang Du, Tang Weixue
Aim To investigate the RBP4/Lp-PLA2/Netrin-1 signal regulation of cognitive function impairment in diabetic nephropathy patients with silent cerebral infarction (SCI). Methods One-hundred patients newly diagnosed with diabetic nephropathy patients were included. The patients were divided into SCI group and NSCI group according to the radiological data. The degrees of cognitive dysfunction were evaluated. Serum RBP4 concentrations were determined by ELISA and protein expressions of Lp-PLA2 and Netrin-1 were determined by Western Blot...
September 2017: Experimental and Clinical Endocrinology & Diabetes
https://www.readbyqxmd.com/read/28663544/plasma-homocysteine-and-cerebral-small-vessel-disease-as-possible-mediators-between-kidney-and-cognitive-functions-in-patients-with-diabetes-mellitus
#17
Mika Sonoda, Tetsuo Shoji, Yukinobu Kuwamura, Yujiro Okute, Toshihide Naganuma, Hideaki Shima, Koka Motoyama, Tomoaki Morioka, Katsuhito Mori, Shinya Fukumoto, Atsushi Shioi, Taro Shimono, Hisako Fujii, Daijiro Kabata, Ayumi Shintani, Masanori Emoto, Masaaki Inaba
Cognitive impairment is more prevalent in those with decreased kidney function. We tested a hypothesis that an increased homocysteine and/or cerebral small vessel diseases (SVDs) mediate the link between kidney and cognitive functions in a cross-sectional study in 143 type 2 diabetes patients without diagnosis of dementia or prior stroke. The exposure and outcome variables were estimated glomerular filtration rate (eGFR) and cognitive performance evaluated with Modified Mini-Mental State (3 MS) examination, respectively...
June 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28631309/obstructive-sleep-apnea-and-silent-cerebral-infarction-in-hypertensive-individuals
#18
José Alvarez-Sabín, Odile Romero, Pilar Delgado, Manuel Quintana, Estevo Santamarina, Alex Ferré, Olga Maisterra, Iolanda Riba-Llena, Joan Montaner, Gabriel Sampol
Obstructive sleep apnea syndrome is very prevalent in hypertensive subjects. Moreover, obstructive sleep apnea syndrome activates multiple processes that might be associated with silent cerebral infarct independently of established risk factors. Our aim is to estimate the frequency of obstructive sleep apnea syndrome in hypertensive patients with and without silent cerebral infarct, and to determine whether obstructive sleep apnea syndrome is an independent risk factor of silent cerebral infarct and/or lacunar silent cerebral infarct in patients with hypertension...
June 20, 2017: Journal of Sleep Research
https://www.readbyqxmd.com/read/28572764/the-effects-of-modified-constraint-induced-movement-therapy-in-acute-subcortical-cerebral-infarction
#19
Changshen Yu, Wanjun Wang, Yue Zhang, Yizhao Wang, Weijia Hou, Shoufeng Liu, Chunlin Gao, Chen Wang, Lidong Mo, Jialing Wu
Background: Constraint-induced movement therapy (CIMT) promotes upper extremity recovery post stroke, however, it is difficult to implement clinically due to its high resource demand and safety of the restraint. Therefore, we propose that modified CIMT (mCIMT) be used to treat individuals with acute subcortical infarction. Objective: To evaluate the therapeutic effects of mCIMT in patients with acute subcortical infarction, and investigate the possible mechanisms underlying the effect. Methods: The role of mCIMT was investigated in 26 individuals experiencing subcortical infarction in the preceding 14 days...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28543314/subclinical-hypothyroidism-and-risk-of-cerebral-small-vessel-disease-a-hospital-based-observational-study
#20
Xiaohao Zhang, Yi Xie, Caixia Ding, Jing Xiao, Yinyan Tang, Xuemei Jiang, Hua Shan, Yuankai Lin, Yujia Zhu, Chuanyou Li, Dan Hu, Zhixiang Ling, Gelin Xu, Lei Sheng
OBJECTIVE: Subclinical hypothyroidism (SCH) has been associated with atherosclerosis and increased risk of ischaemic stroke. However, whether SCH is associated with cerebral small vessel disease (cSVD) remains largely unexplored. This study aimed to investigate the relationship between SCH and total cSVD burden, a composite measurement detected with magnetic resonance imaging (MRI), in patients with minor ischaemic stroke or transient ischaemic attack (TIA). DESIGN: This was a prospective observational cohort study conducted in a tertiary referral hospital...
May 25, 2017: Clinical Endocrinology
keyword
keyword
70988
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"