keyword
https://read.qxmd.com/read/38133877/microarray-evidence-that-8-cell-human-embryos-express-some-hormone-family-members-including-oxytocin
#21
JOURNAL ARTICLE
Amy Lee Harris, Vasiliki Dinopoulou, Dimitris Loutradis, Peter Drakakis, Ann A Kiessling
OBJECTIVE: This study is to discover hormone pathways active in early cleaving human embryos. METHODS: A list of 152 hormones and receptors were compiled to query the microarray database of mRNAs in 8-cell human embryos, two lines of human embryonic stem cells plus human fibroblasts before and after induced pluripotency. RESULTS: Over half of the 152 hormones and receptors were silent on the arrays of all cell types, and more were detected at high or moderate levels on the 8-cell arrays than on the pluripotent cell or fibroblast arrays...
December 22, 2023: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38108033/monitoring-oxytocin-signaling-in-the-brain-more-than-a-love-story
#22
REVIEW
Inga D Neumann
More than any other neuropeptide, oxytocin (OXT) is attracting the attention of neurobiologists, psychologists, psychiatrists, evolutionary biologists and even economists. It is often called a "love hormone" due to its many prosocial functions described in vertebrates including mammals and humans, especially its ability to support "bonding behaviour". Oxytocin plays an important role in female reproduction, as it promotes labour during parturition, enables milk ejection in lactation and is essential for related reproductive behaviours...
November 2023: Comprehensive psychoneuroendocrinology
https://read.qxmd.com/read/38102481/intranasal-oxytocin-in-a-genetic-animal-model-of-autism
#23
JOURNAL ARTICLE
Jakub Szabó, Matúš Mlynár, Andrej Feješ, Emese Renczés, Veronika Borbélyová, Daniela Ostatníková, Peter Celec
Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders mainly characterized by deficient sociability and repetitive behaviors. Effective treatment for the core symptoms of ASD is still lacking. Behavioral interventions show limited effectiveness, while pharmacotherapy focuses on the amelioration of secondary symptomatology. Oxytocin (OXT) is a neuropeptide known for its prosocial impact, making it a candidate drug for ASD treatment. Its alleviating effect has been and still is widely researched, but outcomes reported by clinical studies are ambiguous...
December 15, 2023: Molecular Psychiatry
https://read.qxmd.com/read/38099201/deschloroclozapine-exhibits-an-exquisite-agonistic-effect-at-lower-concentration-compared-to-clozapine-n-oxide-in-hm3dq-expressing-chemogenetically-modified-rats
#24
JOURNAL ARTICLE
Makiko Shimizu, Mitsuhiro Yoshimura, Kazuhiko Baba, Naofumi Ikeda, Yuki Nonaka, Takashi Maruyama, Tatsushi Onaka, Yoichi Ueta
INTRODUCTION: Within the realm of chemogenetics, a particular form of agonists targeting designer receptors exclusively activated by designer drugs (DREADDs) has emerged. Deschloroclozapine (DCZ), a recently introduced DREADDs agonist, demonstrates remarkable potency in activating targeted neurons at a lower dosage compared to clozapine-N-oxide (CNO). METHODS: We conducted a comparative analysis of the effects of subcutaneously administered CNO (1 mg/kg) and DCZ (0...
2023: Frontiers in Neuroscience
https://read.qxmd.com/read/38093006/control-of-lipolysis-by-a-population-of-oxytocinergic-sympathetic-neurons
#25
JOURNAL ARTICLE
Erwei Li, Luhong Wang, Daqing Wang, Jingyi Chi, Zeran Lin, Gordon I Smith, Samuel Klein, Paul Cohen, Evan D Rosen
Oxytocin (OXT), a nine-amino-acid peptide produced in the hypothalamus and released by the posterior pituitary, has well-known actions in parturition, lactation and social behaviour1 , and has become an intriguing therapeutic target for conditions such as autism and schizophrenia2 . Exogenous OXT has also been shown to have effects on body weight, lipid levels and glucose homeostasis1,3 , suggesting that it may also have therapeutic potential for metabolic disease1,4 . It is unclear, however, whether endogenous OXT participates in metabolic homeostasis...
December 13, 2023: Nature
https://read.qxmd.com/read/38071956/oxytocin-receptor-expressing-neurons-in-the-medial-preoptic-area-are-essential-for-lactation-whereas-those-in-the-lateral-septum-are-not-critical-for-maternal-behavior
#26
JOURNAL ARTICLE
Shizu Hidema, Keisuke Sato, Hiroaki Mizukami, Yumi Takahashi, Yuko Maejima, Kenju Shimomura, Katsuhiko Nishimori
INTRODUCTION: In nurturing systems, the oxytocin (Oxt)-oxytocin receptor (Oxtr) system is important for parturition, and essential for lactation and parental behavior. Among the nerve nuclei that express Oxtr, the lateral septal nucleus (LS) and medial preoptic area (MPOA) are representative regions that control maternal behavior. METHODS: We investigated the role of Oxtr- and Oxtr-expressing neurons, located in the LS and MPOA, in regulating maternal behavior by regulating Oxtr expression in a region-specific manner using recombinant mice and adeno-associated viruses...
December 10, 2023: Neuroendocrinology
https://read.qxmd.com/read/38066446/causal-associations-between-covid-19-and-childhood-mental-disorders
#27
JOURNAL ARTICLE
Fei Chen, Hongbao Cao, Ancha Baranova, Qian Zhao, Fuquan Zhang
BACKGROUND: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can invade both the peripheral and central nervous systems and impact the function of the brain. Therefore, it is necessary to evaluate the mutual influences between COVID-19 outcomes and childhood mental disorders. METHODS: We examined genetic correlations and potential causalities between three childhood mental disorders and three COVID-19 phenotypes by genetically proxied analyses. The three mental disorders included attention-deficit/hyperactivity disorder (ADHD, N = 292,548), Tourette's syndrome (TS, N = 14,307), and autism spectrum disorder (ASD, N = 46,350)...
December 8, 2023: BMC Psychiatry
https://read.qxmd.com/read/38042639/circulating-biomarkers-and-risk-of-hypertension-a-two-sample-mendelian-randomisation-study
#28
JOURNAL ARTICLE
Jin Li, Yue-Xian Yao, Pei-Sen Yao
OBJECTIVE: This study systematically assessed circulating proteins to identify new serum biomarkers and risk of hypertension using Mendelian randomisation. METHODS: The associations between 4,782 human circulating proteins and the risk of hypertension were evaluated using two-sample Mendelian randomisation. The FinnGen study demonstrated a link between genetic predisposition and hypertension in 85,438 cases and 223,663 controls. RESULTS: Inverse variance weighted and sensitivity analysis revealed nine proteins in circulation that have a causative effect on hypertension...
December 1, 2023: Heart, Lung & Circulation
https://read.qxmd.com/read/38017588/therapeutic-uses-of-oxytocin-in-stress-related-neuropsychiatric-disorders
#29
REVIEW
Sen Zhang, Ying-Dan Zhang, Dong-Dong Shi, Zhen Wang
Oxytocin (OXT), produced and secreted in the paraventricular nucleus and supraoptic nucleus of magnocellular and parvocellular neurons. The diverse presence and activity of oxytocin suggests a potential for this neuropeptide in the pathogenesis and treatment of stress-related neuropsychiatric disorders (anxiety, depression and post-traumatic stress disorder (PTSD)). For a more comprehensive understanding of the mechanism of OXT's anti-stress action, the signaling cascade of OXT binding to targeting stress were summarized...
November 28, 2023: Cell & Bioscience
https://read.qxmd.com/read/38002996/genomic-signatures-of-positive-selection-in-human-populations-of-the-oxt-oxtr-avp-avpr1a-and-avr1b-gene-variants-related-to-the-regulation-of-psychoemotional-response
#30
JOURNAL ARTICLE
Siroj Yu Bakoev, Anna V Korobeinikova, Arina I Mishina, Shuanat Sh Kabieva, Sergey I Mitrofanov, Alexey A Ivashechkin, Alexsandra I Akinshina, Ekaterina A Snigir, Sergey M Yudin, Vladimir S Yudin, Lyubov V Getmantseva, Elmira A Anderzhanova
The neurobiological systems of maintenance and control of behavioral responses result from natural selection. We have analyzed the selection signatures for single nucleotide variants (SNV) of the genes of oxytocin ( OXT , OXTR ) and vasopressin ( AVP , AVPR1A , AVPR1B ) systems, which are associated with the regulation of social and emotional behavior in distinct populations. The analysis was performed using original WGS (whole genome sequencing) data on Eastern Slavs (SlEast), as well as publicly available data from the 1000 Genomes Project on GBR, FIN, IBR, PUR, BEB, CHB, and ACB populations (the latter were taken as reference)...
November 8, 2023: Genes
https://read.qxmd.com/read/37999545/carbetocin-inhibits-behavioral-sensitization-to-ethanol-in-male-and-female-mice-independent-of-corticosterone-levels
#31
JOURNAL ARTICLE
Beatriz Yamada Costa, Luana Gasparini Santos, Priscila Marianno, Mariana Rae, Marina Gomes de Almeida, Malcon Carneiro de Brito, Rosângela Eichler, Rosana Camarini
Oxytocin (OXT), a pro-social peptide, is increasingly recognized as a potential protective substance against drug addiction. In the context of ethanol, previous research has shown OXT's properties in reducing self-administration, alleviating motor impairment in rodents, and reducing craving in humans. However, its role in behavioral sensitization, a neuroadaptive response resulting from repeated drug exposure linked to an increased drug incentive, remains unexplored. OXT is recognized for its role in regulating the hypothalamic-pituitary-adrenal (HPA) axis, in which corticosterone is acknowledged as a significant factor in the development of behavioral sensitization...
October 31, 2023: Toxics
https://read.qxmd.com/read/37990750/intranasal-oxytocin-in-pediatric-populations-exploring-the-potential-for-reducing-irritability-and-modulating-neural-responses-a-mini-review
#32
JOURNAL ARTICLE
Kennet Sorenson, Emilee Kendall, Hannah Grell, Minjoo Kang, Christopher Shaffer, Soonjo Hwang
Endogenous neuropeptide Oxytocin (OXT) plays a crucial role in modulating pro-social behavior and the neural response to social/emotional stimuli. Intranasal administration is the most common method of delivering OXT. Intranasal OXT has been implemented in clinical studies of various psychiatric disorders with mixed results, mainly related to lack of solid pharmacodynamics and pharmacokinetics model. Due to intranasal OXT's mechanism of reducing the activation of neural areas implicated in emotional responding and emotion regulation, a psychopathology with this target mechanism could be potentially excellent candidate for future clinical trial...
2023: Journal of Psychiatry and Brain Science
https://read.qxmd.com/read/37971993/oxytocinergic-projection-from-the-hypothalamus-to-supramammillary-nucleus-drives-recognition-memory-in-mice
#33
JOURNAL ARTICLE
Junpei Takahashi, Daisuke Yamada, Wakana Nagano, Yoshitake Sano, Teiichi Furuichi, Akiyoshi Saitoh
Oxytocin (OXT) neurons project to various brain regions and its receptor expression is widely distributed. Although it has been reported that OXT administration affects cognitive function, it is unclear how endogenous OXT plays roles in cognitive function. The present study examined the role of endogenous OXT in mice cognitive function. OXT neurons were specifically activated by OXT neuron-specific excitatory Designer Receptors Exclusively Activated by Designer Drug expression system and following administration of clozapine-N-oxide (CNO)...
2023: PloS One
https://read.qxmd.com/read/37961356/natural-variation-in-oxytocin-receptor-signaling-causes-widespread-changes-in-brain-transcription-a-link-to-the-natural-killer-gene-complex
#34
Arjen J Boender, Zachary V Johnson, George W Gruenhagen, Kengo Horie, Brianna E Hegarty, Jeffrey T Streelman, Hasse Walum, Larry J Young
Oxytocin (OXT) is a highly conserved neuropeptide that modulates social cognition, and variation in its receptor gene ( Oxtr ) is associated with divergent social phenotypes. The cellular mechanisms connecting Oxtr genotype to social phenotype remain obscure. We exploit an association between Oxtr polymorphisms and striatal-specific OXTR density in prairie voles to investigate how OXTR signaling influences the brain transcriptome. We discover widespread, OXTR signaling- dependent transcriptomic changes. Interestingly, OXTR signaling robustly modulates gene expression of C-type lectin-like receptors (CTLRs) in the natural killer gene complex, a genomic region associated with immune function...
October 27, 2023: bioRxiv
https://read.qxmd.com/read/37907193/exposure-to-different-pm-2-5-extracts-induces-gliosis-and-changes-behavior-in-male-rats-similar-to-autism-spectrum-disorders-features
#35
JOURNAL ARTICLE
Masoumeh Rahmatinia, Anoushiravan Mohseni-Bandpei, Fariba Khodagholi, Mohammad-Amin Abdollahifar, Mehdi Amouei Torkmahalleh, Meysam Hassani Moghaddam, Philip K Hopke, Ehsan Ghavimehr, Shahriyar Bazzazpour, Abbas Shahsavani
Epidemiological studies have documented that exposure to fine particulate matter (PM2.5 ) could affect neurodevelopment, thereby leading to autism spectrum disorders (ASD). Nevertheless, there is little laboratory data to support this epidemiological evidence. In the current study, we carried out a series of experiments to assess whether developmental exposures to different extracts of PM2.5 can result in ASD-like behavioral, biochemical, and immunohistochemical characteristics in male rat offspring. PM2.5 samples were collected daily for a year, and monthly composites were extracted with an acetone-hexane mixture...
October 29, 2023: Environmental Pollution
https://read.qxmd.com/read/37891399/detection-processing-and-reinforcement-of-social-cues-regulation-by-the-oxytocin-system
#36
REVIEW
Rohit Menon, Inga D Neumann
Many social behaviours are evolutionarily conserved and are essential for the healthy development of an individual. The neuropeptide oxytocin (OXT) is crucial for the fine-tuned regulation of social interactions in mammals. The advent and application of state-of-the-art methodological approaches that allow the activity of neuronal circuits involving OXT to be monitored and functionally manipulated in laboratory mammals have deepened our understanding of the roles of OXT in these behaviours. In this Review, we discuss how OXT promotes the sensory detection and evaluation of social cues, the subsequent approach and display of social behaviour, and the rewarding consequences of social interactions in selected reproductive and non-reproductive social behaviours...
December 2023: Nature Reviews. Neuroscience
https://read.qxmd.com/read/37888000/study-of-the-efficiency-of-a-polycation-using-the-diafiltration-technique-in-the-removal-of-the-antibiotic-oxytetracycline-used-in-aquaculture
#37
JOURNAL ARTICLE
Daniel A Palacio, Pablo Oñate, Samir Esquivel, Manuel Meléndrez, Eduardo Pereira, Bernabé L Rivas
The presence of antibiotics in aquatic systems in recent years has become a global environmental and public health concern due to the appearance of strains resistant to these antibiotics. Oxytetracycline (OXT) is a high-impact antibiotic used for both human and veterinary consumption, and it is the second most used antibiotic in aquaculture in Chile. Based on the above, this problem is addressed using a linear polymer whose structure is composed of aromatic rings and quaternary ammonium groups, which will help enhance the removal capacity of this antibiotic...
October 10, 2023: Membranes
https://read.qxmd.com/read/37887270/the-role-of-oxytocin-in-alzheimer-s-disease-and-its-relationship-with-social-interaction
#38
REVIEW
Junpei Takahashi, Daisuke Yamada, Wakana Nagano, Akiyoshi Saitoh
Alzheimer's disease (AD)-the most common cause of dementia in the elderly-is characterized by progressive memory loss and β-amyloid protein (Aβ) accumulation in the brain. Recently, loneliness was found to be a high risk factor for AD, and social isolation has become a major cause of AD. AD. Oxytocin (OXT), the main hormone involved in social bonding, has been implicated in social interactions, notably in building trust and relationships. Moreover, social isolation or social enrichment modulates the activation of neurons related to OXT...
October 10, 2023: Cells
https://read.qxmd.com/read/37871536/chronic-intranasal-oxytocin-increases-acoustic-eavesdropping-and-adult-neurogenesis
#39
JOURNAL ARTICLE
Patrick K Monari, Zachary J Herro, Jessica Bymers, Catherine A Marler
Social information gathering is a complex process influenced by neuroendocrine-modulated neural plasticity. Oxytocin (OXT) is a key regulator of social decision-making processes such as information gathering, as it contextually modulates social salience and can induce long-term structural plasticity, including neurogenesis. Understanding the link between OXT-induced plasticity and communicative awareness is crucial, particularly because OXT is being considered for treatment of social pathologies. We investigated the role of chronic OXT-dependent plasticity in attention to novel social information by manipulating the duration of time following cessation of intranasal treatment to allow for the functional integration of adult-born neurons resulting from OXT treatment...
October 21, 2023: Hormones and Behavior
https://read.qxmd.com/read/37869605/antibiotic-photocatalysis-and-antimicrobial-activity-of-low-cost-multifunctional-fe-3-o-4-hap-nanocomposites
#40
JOURNAL ARTICLE
J Labrag, M Abbadi, M Hnini, C El Bekkali, A Bouziani, D Robert, J Aurag, A Laghzizil, J-M Nunzi
Water contamination by multiple pollutants is a serious environmental issue originating from the many diverse sources of pollution. It has worsened with the appearance of new contaminants, named emerging micropollutants, such as drug residues which are considered a potential threat to human health and/or ecosystems. These require prior treatment before release into the environment. Simultaneous adsorption and photocatalysis as well as solid-liquid separation are promising technologies for water treatment. In order to obtain low cost photoactive nanocomposites, porous and magnetic Fe3 O4 -hydroxyapatite (wFeHAp) nanocomposites were prepared by soft chemistry from the dissociation of natural phosphate into Ca2+ and H3 PO4 precursors, further neutralized by ammonia in the presence of preformed Fe3 O4 particles...
December 2023: Journal of Environmental Health Science & Engineering
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