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https://www.readbyqxmd.com/read/27871902/the-effects-of-long-term-estradiol-treatment-on-social-behavior-and-gene-expression-in-adult-female-rats
#1
Alexandra N Garcia, Kelsey Bezner, Christina Depena, Weiling Yin, Andrea C Gore
This study tested the effects of long-term estradiol (E2) replacement on social behavior and gene expression in brain nuclei involved in the regulation of these social behaviors in adult female rats. We developed an ultrasonic vocalization (USV) test and a sociability test to examine communications, social interactions, and social preference, using young adult female cagemates. All rats were ovariectomized (OVX) and implanted with a Silastic capsule containing E2 or vehicle, and housed in same-treatment pairs for a 3-month period...
November 19, 2016: Hormones and Behavior
https://www.readbyqxmd.com/read/27866504/oxytocin-reduces-face-processing-time-but-leaves-recognition-accuracy-and-eye-gaze-unaffected
#2
Kelly Hubble, Katie Daughters, Antony S R Manstead, Aled Rees, Anita Thapar, Stephanie H M van Goozen
OBJECTIVES: Previous studies have found that oxytocin (OXT) can improve the recognition of emotional facial expressions; it has been proposed that this effect is mediated by an increase in attention to the eye-region of faces. Nevertheless, evidence in support of this claim is inconsistent, and few studies have directly tested the effect of oxytocin on emotion recognition via altered eye-gaze Methods: In a double-blind, within-subjects, randomized control experiment, 40 healthy male participants received 24 IU intranasal OXT and placebo in two identical experimental sessions separated by a 2-week interval...
November 21, 2016: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/27862641/association-between-oxytocin-receptor-genotype-maternal-care-and-eating-disorder-behaviours-in-a-community-sample-of-women
#3
Nadia Micali, Marta Crous-Bou, Janet Treasure, Elizabeth A Lawson
This study aimed to investigate associations between oxytocin receptor gene (OXT-R) polymorphisms (rs53576 and rs2254298), their interaction with maternal care (GxE), and ED behaviours in a community sample. We studied 3698 women from the Avon Longitudinal Study of Parents and Children (ALSPAC) who participated in a two-phase prevalence study of lifetime ED and had genotype data. The GG rs53576 genotype was associated with binge eating and purging, and the rs2254298 AG/AA genotype with restrictive eating lifetime...
November 14, 2016: European Eating Disorders Review: the Journal of the Eating Disorders Association
https://www.readbyqxmd.com/read/27829122/opposite-effects-of-central-oxytocin-and-arginine-vasopressin-on-changes-in-gastric-motor-function-induced-by-chronic-stress
#4
Mehmet Bülbül, Osman Sinen, Burcu Gemici, V Nimet İzgüt-Uysal
Hypothalamic oxytocin (OXT) and arginine vasopressin (AVP) are known to act oppositely on hypothalamic-pituitary-adrenal (HPA) axis, stress response and gastrointestinal (GI) motility. In rodents, exposure to restraint stress (RS) delays gastric emptying (GE), however, repeated exposure to the same stressor (chronic homotypic stress (CHS)), the delayed GE is restored to basal level, while hypothalamic OXT is upregulated. In contrast, when rats are exposed to chronic heterotypic stress (CHeS), these adaptive changes are not observed...
November 6, 2016: Peptides
https://www.readbyqxmd.com/read/27818356/association-between-oxytocin-and-receptor-genetic-polymorphisms-and-aggression-in-a-northern-chinese-han-population-with-alcohol-dependence
#5
Ling Yang, Fan Wang, Meiling Wang, Mei Han, Lufeng Hu, Minghua Zheng, Ji Ma, Yimin Kang, Pengxiang Wang, Hongqiang Sun, Wei Zuo, Longteng Xie, Aiju Wang, Dongsheng Yu, Yanlong Liu
OBJECTIVE: Alcohol dependence (AD) is a common chronic brain disorder precipitated by complex interactions between biological, genetic, and environmental risk factors. Aggression often occurs in the context of AD. Previous studies have shown that Oxytocin (OXT) and OXT receptor (OXTR) are involved in the regulation of aggression. The present study investigated whether variations and interactions of OXT and OXTR genes were associated with AD-related aggression in a genetically homogeneous northern Chinese Han population...
November 3, 2016: Neuroscience Letters
https://www.readbyqxmd.com/read/27790153/nerve-growth-factor-brain-derived-neurotrophic-factor-and-osteocalcin-gene-relationship-in-energy-regulation-bone-homeostasis-and-reproductive-organs-analyzed-by-mrna-quantitative-evaluation-and-linear-correlation-analysis
#6
Claudia Camerino, Elena Conte, Maria Cannone, Roberta Caloiero, Adriano Fonzino, Domenico Tricarico
Nerve Growth Factor (NGF)/Brain-derived Neurotrophic Factor (BDNF) and osteocalcin share common effects regulating energy, bone mass, reproduction and neuronal functions. To investigate on the gene-relationship between NGF, BDNF, and Osteocalcin we compared by RT-PCR the transcript levels of Ngf, Bdnf and Osteocalcin as well as of their receptors p75NTR/NTRK1, NTRK2, and Gprc6a in brain, bone, white/brown adipose tissue (WAT/BAT) and reproductive organs of 3 months old female and male mice. Brain and bone were used as positive controls for NGF/BDNF and Osteocalcin respectively...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27785749/revealing-the-neuroendocrine-response-after-remoxipride-treatment-using-multi-biomarker-discovery-and-quantifying-it-by-pk-pd-modeling
#7
Willem J van den Brink, Yin C Wong, Berfin Gülave, Piet H van der Graaf, Elizatbeth C M de Lange
To reveal unknown and potentially important mechanisms of drug action, multi-biomarker discovery approaches are increasingly used. Time-course relationships between drug action and multi-biomarker profiles, however, are typically missing, while such relationships will provide increased insight in the underlying body processes. The aim of this study was to investigate the effect of the dopamine D2 antagonist remoxipride on the neuroendocrine system. Different doses of remoxipride (0, 0.7, 5.2, or 14 mg/kg) were administered to rats by intravenous infusion...
October 26, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27773348/endometrial-prostaglandin-synthases-ovarian-steroids-and-oxytocin-receptors-in-mares-with-oxytocin-induced-luteal-maintenance
#8
Maria R Rebordão, António Galvão, Pedro Pinto-Bravo, Joana Pinheiro, Sandra Gamboa, Elisabete Silva, Luísa Mateus, Graça Ferreira-Dias
Oxytocin (OXT) has been used to prolong the luteal phase in mares, but its mechanism of action is unknown. The aim of this study was to evaluate the effect of chronic exogenous OXT administration to mid-luteal phase mares on luteal maintenance. Also, endometrial expression of prostaglandin endoperoxide synthase 2 (PTGS2), prostaglandin F2α, E2 and I2 synthases (AKR1C3, PTGES, and PTGIS), oxytocin receptor (OXTR), progesterone receptor (PGR), and estrogen receptors 1 (ESR1) and 2 (ESR2) were assessed in mares experiencing luteal maintenance 2 weeks after chronic exogenous OXT administration...
September 8, 2016: Theriogenology
https://www.readbyqxmd.com/read/27752839/levels-of-metabolic-markers-in-drug-naive-prediabetic-and-type-2-diabetic-patients
#9
Amal Akour, Violet Kasabri, Nailya Boulatova, Yasser Bustanji, Randa Naffa, Dana Hyasat, Nahla Khawaja, Haidar Bustanji, Ayman Zayed, Munther Momani
AIMS: Type 2 diabetes mellitus (T2DM) and prediabetes (pre-DM) are associated with changes in levels of metabolic markers. The main aim of this study is to compare the levels of omentin, irisin, endothelin-1, nesfatin, hepatocyte growth factor (HGF), fibroblast growth factor, and oxytocin (OXT) between normoglycemic and pre-DM/T2DM obese Jordanian patients. METHODS: One hundred and ninety-eight adult Jordanian subjects were recruited. Demographic data and clinical parameters were collected...
October 18, 2016: Acta Diabetologica
https://www.readbyqxmd.com/read/27743608/effects-of-chronic-restraint-stress-on-social-behaviors-and-the-number-of-hypothalamic-oxytocin-neurons-in-male-rats
#10
Jin Li, Han-Xia Li, Xiao-Jing Shou, Xin-Jie Xu, Tian-Jia Song, Song-Ping Han, Rong Zhang, Ji-Sheng Han
Oxytocin (OXT) and vasopressin (AVP) are considered to be related to mammalian social behavior and the regulation of stress responses. The present study investigated the effects of chronic homotypic restraint stress (CHRS) on social behaviors and anxiety, as well as its repercussions on OXT- and AVP-positive neurons in the paraventricular nucleus (PVN) and supraoptic nucleus (SON) nuclei in rat. Male Sprague-Dawley rats receiving CHRS were exposed to repeated restraint stress of 30min per day for 10days. Changes in social approach behaviors were evaluated with the three-chambered social approach task...
December 2016: Neuropeptides
https://www.readbyqxmd.com/read/27740964/beneficial-effects-of-chronic-oxytocin-administration-and-social-co-housing-in-a-rodent-model-of-post-traumatic-stress-disorder
#11
Eric M Janezic, Swetha Uppalapati, Stephanie Nagl, Marco Contreras, Edward D French, Jean-Marc Fellous
Post-traumatic stress disorder (PTSD) is in part due to a deficit in memory consolidation and extinction. Oxytocin (OXT) has anxiolytic effects and promotes prosocial behaviors in both rodents and humans, and evidence suggests that it plays a role in memory consolidation. We studied the effects of administered OXT and social co-housing in a rodent model of PTSD. Acute OXT yielded a short-term increase in the recall of the traumatic memory if administered immediately after trauma. Low doses of OXT delivered chronically had a cumulating anxiolytic effect that became apparent after 4 days and persisted...
October 12, 2016: Behavioural Pharmacology
https://www.readbyqxmd.com/read/27717050/transient-and-persistent-behavioral-and-molecular-changes-in-primiparous-female-wistar-rats
#12
Roshan R Naik, Trynke R de Jong
Motherhood brings about a multitude of behavioral and physiological changes in dams and some of these persist until after weaning. We studied behavioral changes associated with reproductive experience at lactating day (LD)8, at weaning (LD21), and 28 days post-weaning (PW28) compared to nulliparous (NP) females. Furthermore, in another cohort of animals, we quantified mRNA expression of five target genes known to be associated with maternal experience: arginin-vasopressin(Avp) and its 1A receptor(Avpr1a), oxytocin(Oxt) and its receptor(Oxtr), and corticotropin-releasing hormone(Crh) in three key maternal region: the medial preoptic area (MPOA), bed nucleus of the stria terminalis (BNST) and paraventricular hypothalamic nucleus(PVN)...
September 26, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27641503/a-cortical-circuit-for-sexually-dimorphic-oxytocin-dependent-anxiety-behaviors
#13
Kun Li, Miho Nakajima, Ines Ibañez-Tallon, Nathaniel Heintz
The frequency of human social and emotional disorders varies significantly between males and females. We have recently reported that oxytocin receptor interneurons (OxtrINs) modulate female sociosexual behavior. Here, we show that, in male mice, OxtrINs regulate anxiety-related behaviors. We demonstrate that corticotropin-releasing-hormone-binding protein (CRHBP), an antagonist of the stress hormone CRH, is specifically expressed in OxtrINs. Production of CRHBP blocks the CRH-induced potentiation of postsynaptic layer 2/3 pyramidal cell activity of male, but not female, mice, thus producing an anxiolytic effect...
September 22, 2016: Cell
https://www.readbyqxmd.com/read/27633648/effects-of-intranasal-oxytocin-on-long-term-memory-in-healthy-humans-a-systematic-review
#14
Michela Brambilla, Rosa Manenti, Giovanni de Girolamo, Mauro Adenzato, Luisella Bocchio-Chiavetto, Maria Cotelli
Preclinical Research The neuropeptide oxytocin (Oxt) is implicated in complex emotional and social behaviors and appears to play an important role in learning and memory. Animal studies have shown that the effects of exogenous Oxt on memory vary according to the timing of administration, context, gender, and dose and may improve the memory of social, but not nonsocial stimuli. Oxt is intimately involved in a broad array of neuropsychiatric functions and may therefore be a pharmacological target for several psychiatric disorders...
September 16, 2016: Drug Development Research
https://www.readbyqxmd.com/read/27590137/local-interleukin-18-system-in-the-basolateral-amygdala-regulates-susceptibility-to-chronic-stress
#15
Tae-Kyung Kim, Ji-Eun Kim, Juli Choi, Jin-Young Park, Jung-Eun Lee, Eun-Hwa Lee, Yunjin Lee, Bo Yeon Kim, Young J Oh, Pyung-Lim Han
Interleukin-18 (IL18) is a multifunctional cytokine that has been implicated in increased susceptibility to depression; however, the underlying mechanism remains unknown. We found that the IL18 system in the basolateral amygdala (BLA) determined susceptibility to chronic stress. Mice subjected to chronic restraint stress or chronic foot-shock stress demonstrated increased expression of IL18 in the BLA, and exhibited depression-like behaviors, whereas IL18 knockout (KO) mice were resilient to these chronic stresses...
September 2, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/27578619/the-correlation-between-plasma-levels-of-oxytocin-and-betatrophin-in-non-diabetic-and-diabetic-metabolic-syndrome-patients-a-cross-sectional-study-from-jordan
#16
Amani Al-Rawashdeh, Violet Kasabri, Nailya Bulatova, Amal Akour, Ayman Zayed, Munther Momani, Nahla Khawaja, Haider Bustanji, Dana Hyasat
BACKGROUND: Oxytocin (OXT) is a neurohypophyseal hormone that has been recently shown to possess a number of beneficial effects in diabetes and obesity. Betatrophin is a protein expressed in fat and liver that regulates lipid metabolism and promotes pancreatic β-cell proliferation. It is not investigated yet whether OXT and betatrophin levels correlate in metabolic syndrome (MS) or diabetes patients. METHODS: The aim was to assess correlations between plasma betatrophin and OXT levels in MS-diabetic or prediabetic (N=89) as compared to MS-non-diabetic (N=69) patients...
August 22, 2016: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/27571134/impact-of-low-dose-oral-exposure-to-bisphenol-a-bpa-on-the-neonatal-rat-hypothalamic-and-hippocampal-transcriptome-a-clarity-bpa-consortium-study
#17
Sheryl E Arambula, Scott M Belcher, Antonio Planchart, Stephen D Turner, Heather B Patisaul
Bisphenol A (BPA) is an endocrine disrupting, high volume production chemical found in a variety of products. Evidence of prenatal exposure has raised concerns that developmental BPA may disrupt sex-specific brain organization and, consequently, induce lasting changes on neurophysiology and behavior. We and others have shown that exposure to BPA at doses below the no-observed-adverse-effect level can disrupt the sex-specific expression of estrogen-responsive genes in the neonatal rat brain including estrogen receptors (ERs)...
October 2016: Endocrinology
https://www.readbyqxmd.com/read/27562397/progesterone-response-element-variation-in-the-oxtr-promoter-region-and-paternal-care-in-new-world-monkeys
#18
Pedro Vargas-Pinilla, Paul Babb, Leandro Nunes, Pâmela Paré, Gabrielle Rosa, Aline Felkl, Dânae Longo, Francisco M Salzano, Vanessa R Paixão-Côrtes, Gislene Lopes Gonçalves, Maria Cátira Bortolini
Paternal care is a complex social behavior common in primate species with socially monogamous mating systems and twin births. Evolutionary causes and consequences of such behavior are not well understood, nor are their neuroendocrine and genetic bases. However, the neuropeptide oxytocin (OXT) and its receptor (OXTR) are associated with parental care in mammalian lineages. Here we investigated the interspecific variation in the number of progesterone response elements (PREs) in the OXTR promoter region of 32 primate species, correlating genetic data with behavior, social systems, and ecological/life-history parameters, while controlling for phylogeny...
August 25, 2016: Behavior Genetics
https://www.readbyqxmd.com/read/27556112/impaired-social-cognition-processes-in-asperger-syndrome-and-anorexia-nervosa-in-search-for-endophenotypes-of-social-cognition
#19
REVIEW
Beata Joanna Kasperek-Zimowska, Janusz Grzegorz Zimowski, Katarzyna Biernacka, Katarzyna Kucharska-Pietura, Filip Rybakowski
A growing number of publications indicates presence of significant deficits in social cognition in patients with anorexia nervosa (AN). These deficits appear to be comparable in qualitative and quantitative dimension with impairment of the same functions among people with Asperger syndrome (AS). The aim of this study is to identify subject areas in the field of impairment of social cognition processes among people with Asperger syndrome and anorexia nervosa taking into consideration the potential contribution of genetic pathways of oxytocin and vasopressin in the pathogenesis of these diseases...
2016: Psychiatria Polska
https://www.readbyqxmd.com/read/27536785/increased-serum-levels-of-oxytocin-in-treatment-resistant-depression-in-adolescents-trdia-group
#20
Tsuyoshi Sasaki, Kenji Hashimoto, Yasunori Oda, Tamaki Ishima, Madoka Yakita, Tsutomu Kurata, Masaru Kunou, Jumpei Takahashi, Yu Kamata, Atsushi Kimura, Tomihisa Niitsu, Hideki Komatsu, Tadashi Hasegawa, Akihiro Shiina, Tasuku Hashimoto, Nobuhisa Kanahara, Eiji Shimizu, Masaomi Iyo
OBJECTIVE: 'Treatment-resistant depression' is depression that does not respond to an adequate regimen of evidence-based treatment. Treatment-resistant depression frequently becomes chronic. Children with treatment-resistant depression might also develop bipolar disorder (BD). The objective of this study was to determine whether serum levels of oxytocin (OXT) in treatment-resistant depression in adolescents (TRDIA) differ from non-treatment-resistant depression in adolescents (non-TRDIA) or controls...
2016: PloS One
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