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https://www.readbyqxmd.com/read/28195302/testing-biomechanical-models-of-human-lumbar-lordosis-variability
#1
Eric R Castillo, Connie Hsu, Ross W Mair, Daniel E Lieberman
OBJECTIVES: Lumbar lordosis (LL) is a key adaptation for bipedalism, but factors underlying curvature variations remain unclear. This study tests three biomechanical models to explain LL variability. MATERIALS AND METHODS: Thirty adults (15 male, 15 female) were scanned using magnetic resonance imaging (MRI), a standing posture analysis was conducted, and lumbar range of motion (ROM) was assessed. Three measures of LL were compared. The trunk's center of mass was estimated from external markers to calculate hip moments (Mhip ) and lumbar flexion moments...
February 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28180978/3d-rod-shape-changes-in-adolescent-idiopathic-scoliosis-instrumentation-how-much-does-it-impact-correction
#2
Franck Le Navéaux, Carl-Eric Aubin, Stefan Parent, Peter O Newton, Hubert Labelle
PURPOSE: Flattening of rods is known to reduce the correction capability of the instrumentation, but has not been studied in 3D. The aim is to evaluate the rods shape 3D changes during and immediately after instrumentation, and its effect on 3D correction. METHODS: The 5.5 mm CoCr rods of 35 right thoracic adolescent idiopathic scoliosis patients were measured from rod tracings prior to insertion, and reconstructed in 3D from bi-planar radiographs taken intra-operatively after the correction maneuvers and 1 week post-operatively...
February 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28174019/understanding-idiopathic-scoliosis-a-new-zebrafish-school-of-thought
#3
REVIEW
Curtis W Boswell, Brian Ciruna
Idiopathic scoliosis (IS) refers to a 3D rotation of the spine that occurs in the absence of underlying vertebral anomalies or obvious physiological defects. Despite affecting approximately 4% of the population, the etiology and pathogenesis of IS remain poorly understood, largely due to genetic heterogeneity and historical lack of appropriate developmental models. Recently, zebrafish has emerged as a powerful system for studying IS, owing to well-developed genetic resources and a natural susceptibility to spinal curvatures...
February 4, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28161236/minimally-invasive-decompression-surgery-for-lumbar-spinal-stenosis-with-degenerative-scoliosis-predictive-factors-of-radiographic-and-clinical-outcomes
#4
Akihito Minamide, Munehito Yoshida, Hiroki Iwahashi, Andrew K Simpson, Hiroshi Yamada, Hiroshi Hashizume, Yukihiro Nakagawa, Hiroshi Iwasaki, Shunji Tsutsui, Ryohei Kagotani, Mayumi Sonekatsu, Takahide Sasaki, Kazunori Shinto, Tsuyoshi Deguchi
There is ongoing controversy regarding the most appropriate surgical treatment for lumbar spinal stenosis (LSS) with concurrent degenerative lumbar scoliosis (DLS): decompression alone, decompression with limited spinal fusion, or long spinal fusion for deformity correction. The coexistence of degenerative stenosis and deformity is a common scenario; Nonetheless, selecting the appropriate surgical intervention requires thorough understanding of the patients clinical symptomatology as well as radiographic parameters...
February 1, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28155829/activity-of-dr-j%C3%A3-zef-aleksiewicz-phd-towards-the-development-of-orthopedics-and-rehabilitation-in-lviv-in-the-years-1912-1930
#5
Sławomir Jandziś, Stanisław Zaborniak
The article describes the work of Dr Aleksiewicz towards the development of orthopedics and rehabilitation in Lviv in the years 1912-1930 based on source materials belonging to his family and articles published in medical journals and daily press. In 1919, Dr Aleksiewicz established a Surgical and Orthopedic Department and a factory of prostheses at the Disabled House in Lviv. He also formed a 200-bed division for the visually impaired with basket- and comb-making workshops as well as massage and typing courses...
March 23, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28139008/oxidative-stress-mediated-developmental-toxicity-induced-by-isoniazide-in-zebrafish-embryos-and-larvae
#6
Yu Zou, Yun Zhang, Liwen Han, Qiuxia He, Hairong Hou, Jian Han, Ximin Wang, Chengyun Li, Juan Cen, Kechun Liu
Isoniazide (INH) is an important first-line drug that is used to treat tuberculosis. However, the effect of INH on fetal growth has not yet been elucidated, and the mechanism of INH-induced developmental toxicity is still unknown. In the present study, we employed zebrafish embryos and larvae to investigate the developmental toxicity of INH. The survival rates of the embryos and larvae as well as the hatching rates of embryos were significantly reduced. Morphological abnormalities, including spinal curvature, yolk retention, swimming bladder absence, tail bending and shorter body lengths were induced by INH...
January 31, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28130805/topologically-preserving-straightening-of-spinal-cord-mri
#7
Benjamin De Leener, Gabriel Mangeat, Sara Dupont, Allan R Martin, Virginie Callot, Nikola Stikov, Michael G Fehlings, Julien Cohen-Adad
PURPOSE: To propose a robust and accurate method for straightening magnetic resonance (MR) images of the spinal cord, based on spinal cord segmentation, that preserves spinal cord topology and that works for any MRI contrast, in a context of spinal cord template-based analysis. MATERIALS AND METHODS: The spinal cord curvature was computed using an iterative Non-Uniform Rational B-Spline (NURBS) approximation. Forward and inverse deformation fields for straightening were computed by solving analytically the straightening equations for each image voxel...
January 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28126356/efficacy-comparison-of-accell-evo3%C3%A2-and-grafton%C3%A2-demineralized-bone-matrix-putties-against-autologous-bone-in-a-rat-posterolateral-spine-fusion-model
#8
Antonio T Brecevich, Paul D Kiely, B Victor Yoon, Joseph T Nguyen, Frank P Cammisa, Celeste Abjornson
BACKGROUND CONTEXT: Spinal fusion procedures are intended to stabilize the spinal column for a multitude of disorders including abnormal curvature, traumatic instability, degenerative instability, and damage from infections or tumors. As an aid in the bone healing response, bone graft materials are utilized to bridge joints for arthrodesis and promote unions in pseudoarthrosis. Currently, the gold standard for stabilizing fusion masses in spinal procedures involves utilizing the osteogenic, osteoinductive, and osteoconductive properties of autologous iliac crest cortico-cancellous bone...
January 23, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28117436/safety-and-efficacy-of-single-stage-surgical-treatment-for-congenital-scoliosis-associated-with-intraspinal-mass
#9
Bo-Bo Zhang, Hui-Ren Tao, Tai-Lin Wu, Lin Wang, Chun-Guang Duan, Tao Zhang, Tao Li, Wei-Zhou Yang, Ming Liu, Jun Ma
For congenital scoliosis associated with intraspinal anomaly, surgical treatment is often advocated. However, the safety and efficacy of single-stage intraspinal mass resection and scoliosis correction remain unclear. The purpose of this study was to retrospectively evaluate the feasibility and risk factors of single-stage surgical treatment for congenital scoliosis associated with intraspinal mass. Patients' clinical records were reviewed for demographic and radiographic data, operating time, intraoperative blood loss, perioperative complications, and postoperative pathologic results...
January 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28116313/the-influence-of-the-straighten-your-back-command-on-the-sagittal-spinal-curvatures-in-children-with-generalized-joint-hypermobility
#10
Dariusz Czaprowski, Paulina Pawłowska, Aleksandra Kolwicz-Gańko, Dominik Sitarski, Agnieszka Kędra
Objectives. The aim of the study was to assess the change of sagittal spinal curvatures in children with generalized joint hypermobility (GJH) instructed with "straighten your back" command (SYB). Methods. The study included 56 children with GJH. The control group consisted of 193 children. Sacral slope (SS), lumbar lordosis (LL), global thoracic kyphosis (TK), lower thoracic kyphosis (LK), and upper thoracic kyphosis (UK) were assessed with Saunders inclinometer both in spontaneous positions (standing and sitting) and after the SYB...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28112560/evaluating-stone-free-status-following-percutaneous-stone-procedures-in-patients-with-spina-bifida-do-anatomical-factors-play-a-role
#11
Rajeev Chaudhry, Katherine Theisen, Heidi Stephany, Francis Schneck, Glenn Cannon, Michael C Ost
PURPOSE: Percutaneous stone surgery can be challenging in spina bifida (SB) patients due to their body habitus and spinal cord anomalies. A safe surgical approach may necessitate acceptance of lower stone-free rates. We seek to determine if anatomic complexity, as measured by spinal cord curvature and torso length, is associated with stone-free rates after percutaneous stone surgery in SB patients. We hypothesize that increasing anatomic complexity is associated with lower stone-free rates following percutaneous stone surgery...
January 23, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28103119/iatrogenic-spinal-cord-injury-in-a-trauma-patient-with-ankylosing-spondylitis
#12
Ahmad Maarouf, Colleen M McQuown, Jennifer A Frey, Rami A Ahmed, Lisa Derrick
BACKGROUND: The recommended practice for over 30 years has been to routinely immobilize patients with unstable cervical spinal injuries using cervical spinal collars. It is shown that patients with Ankylosing spondylitis (AS) are four times more likely to suffer a spinal fracture compared to the general population and have an eleven-fold greater risk of spinal cord injury. Current protocols of spinal immobilization were responsible for secondary neurologic deterioration in some of these patients...
January 19, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28097045/homeopathy-a-safe-much-less-expensive-non-invasive-viable-alternative-for-the-treatment-of-patients-suffering-from-loss-of-lumbar-lordosis
#13
Saiful Haque, Debarsi Das, Saugato Bhattacharya, Tathagato Sarkar, Anisur Rahman Khuda-Bukhsh
OBJECTIVES: Loss of lumbar lordosis causing pain and curvature of the vertebral skeleton to one side is a relatively uncommon disease. To our knowledge, successful treatment of loss of lumbar lordosis with any potentized homeopathic drug diluted above Avogadro's limit (that is, above a potency of 12C) has not been documented so far. In this communication, we intend to document a relatively rare case of loss of lumbar lordosis with osteophytic lippings, disc desiccation, and protrusion, causing a narrowing of secondary spinal canal and a bilateral neural foramina, leading to vertebral column curvature with acute pain in an adolescent boy...
December 2016: Journal of Pharmacopuncture
https://www.readbyqxmd.com/read/28092118/incorporation-of-ct-based-measurements-of-trunk-anatomy-into-subject-specific-musculoskeletal-models-of-the-spine-influences-vertebral-loading-predictions
#14
Alexander G Bruno, Hossein Mokhtarzadeh, Brett T Allaire, Kelsey R Velie, M Clara De Paolis Kaluza, Dennis E Anderson, Mary L Bouxsein
We created subject-specific musculoskeletal models of the thoracolumbar spine by incorporating spine curvature and muscle morphology measurements from computed tomography (CT) scans to determine the degree to which vertebral compressive and shear loading estimates are sensitive to variations in trunk anatomy. We measured spine curvature and trunk muscle morphology using spine CT scans of 125 men, and then created four different thoracolumbar spine models for each person: (i) height and weight adjusted (Ht/Wt models); (ii) height, weight, and spine curvature adjusted (+C models); (iii) height, weight, and muscle morphology adjusted (+M models); and (iv) height, weight, spine curvature, and muscle morphology adjusted (+CM models)...
January 16, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28079273/abnormal-fetal-muscle-forces-result-in-defects-in-spinal-curvature-and-alterations-in-vertebral-segmentation-and-shape
#15
Rebecca A Rolfe, James H Bezer, Tyler Kim, Ahmed Z Zaidon, Michelle L Oyen, James C Iatridis, Niamh C Nowlan
The incidence of congenital spine deformities, including congenital scoliosis, kyphosis and lordosis, may be influenced by the in utero mechanical environment, and particularly by fetal movements at critical time-points. There is a limited understanding of the influence of fetal movements on spinal development, despite the fact that mechanical forces have been shown to play an essential role in skeletal development of the limb. This study investigates the effects of muscle forces on spinal curvature, vertebral segmentation and vertebral shape by inducing rigid or flaccid paralysis in the embryonic chick...
January 12, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28060179/uniplanar-versus-fixed-pedicle-screws-in-the-correction-of-thoracic-kyphosis-in-the-treatment-of-adolescent-idiopathic-scoliosis-ais
#16
Siddharth A Badve, Ryan C Goodwin, David Gurd, Thomas Kuivila, Swamy Kurra, William F Lavelle
BACKGROUND: The aim of surgical treatment of scoliosis is to obtain fusion of the spinal column, balanced in the coronal and sagittal planes. Great success has been attained with coronal correction; however, the sagittal profile has received less attention, resulting in little correction of sagittal plane alignment. The purpose of this study was to compare uniplanar and fixed pedicle screws in the correction of the thoracic sagittal alignment in the treatment of adolescent idiopathic scoliosis (AIS)...
January 5, 2017: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/28057167/moderate-dose-regular-lifelong-alcohol-intake-changes-the-intestinal-flora-protects-against-aging-and-keeps-spatial-memory-in-the-senescence-accelerated-mouse-prone-8-samp8-model
#17
Chikako Shimizu, Yasuhiro Oki, Yutaka Mitani, Youichi Tsuchiya, Toshitaka Nabeshima
PURPOSE: Heavy and long-term alcohol consumption increase the risk of alcohol-related diseases. Epidemiological studies show moderate drinking reduces the risk of mortality, cardiovascular diseases, and brain infarction in the J-shaped or U-shaped curve effect. However, why moderate drinkers may be healthy and non-drinkers may be ill in diverse populations remains controversial. Herein, we examined the relationship between moderate/lifelong alcohol intake and aging, especially aging-related cognitive functions in senescence-accelerated mouse prone 8 (SAMP8) model...
October 2016: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28050819/preventing-fusion-mass-shift-avoids-postoperative-distal-curve-adding-on-in-adolescent-idiopathic-scoliosis
#18
Hideki Shigematsu, Jason Pui Yin Cheung, Mauro Bruzzone, Hiroaki Matsumori, Kin-Cheung Mak, Dino Samartzis, Keith Dip Kei Luk
BACKGROUND: Surgery for adolescent idiopathic scoliosis (AIS) is only complete after achieving fusion to maintain the correction obtained intraoperatively. The instrumented or fused segments can be referred to as the "fusion mass". In patients with AIS, the ideal fusion mass strategy has been established based on fulcrum-bending radiographs for main thoracic curves. Ideally, the fusion mass should achieve parallel endplates of the upper and lower instrumented vertebra and correct any "shift" for truncal balance...
January 3, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28046323/su-f-t-642-sub-millimeter-accurate-setup-of-more-than-three-vertebrae-in-spinal-sbrt-with-6d-couch
#19
X Wang, Z Zhao, J Yang, J Yang, M McAleer, P Brown, J Li, A Ghia
PURPOSE: To assess the initial setup accuracy in treating more than 3 vertebral body levels in spinal SBRT using a 6D couch. METHODS: We retrospectively analyzed last 20 spinal SBRT patients (4 cervical, 9 thoracic, 7 lumbar/sacrum) treated in our clinic. These patients in customized immobilization device were treated in 1 or 3 fractions. Initial setup used ExacTrac and Brainlab 6D couch to align target within 1 mm and 1 degree, following by a cone beam CT (CBCT) for verification...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046288/we-de-201-06-impact-of-temporal-image-coregistration-methods-on-3d-internal-dose-calculations-in-targeted-radionuclide-therapy
#20
A Besemer, I Marsh, B Bednarz
PURPOSE: The calculation of 3D internal dose calculations in targeted radionuclide therapy requires the acquisition and temporal coregistration of a serial PET/CT or SPECT/CT images. This work investigates the dosimetric impact of different temporal coregistration methods commonly used for 3D internal dosimetry. METHODS: PET/CT images of four mice were acquired at 1, 24, 48, 72, 96, 144 hrs post-injection of (124) I-CLR1404. The therapeutic (131) I-CLR1404 absorbed dose rate (ADR) was calculated at each time point using a Geant4-based MC dosimetry platform using three temporal image coregistration METHODS: (1) no coregistration (NC), whole body sequential CT-CT affine coregistration (WBAC), and individual sequential ROI-ROI affine coregistration (IRAC)...
June 2016: Medical Physics
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