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https://www.readbyqxmd.com/read/28342993/teratogenic-responses-of-zebrafish-embryos-to-decabromodiphenyl-ether-bde-209-in-the-presence-of-nano-sio2-particles
#1
Shu-Ju Chao, Chin Pao Huang, Pei-Chung Chen, Chihpin Huang
This study investigated the influence of nano-SiO2 particles (nSiO2) on the teratogenic responses of zebrafish embryos to decabromodiphenyl ether (BDE-209). Zebrafish embryos were exposed to BDE-209 in the absence and presence of nSiO2 for 96 h post fertilization (hpf). Results showed that formation of nSiO2-BDE-209 associates promoted both extracellular and intracellular uptake of BDE-209 by zebrafish embryos, thereby increasing the bioconcentration of BDE-209 on the chorion surface and the embryos. Results also showed embryos delay hatching temporarily when co-exposure to BDE-209 and nSiO2 at 60 hpf...
March 20, 2017: Chemosphere
https://www.readbyqxmd.com/read/28330796/chronic-low-back-pain-after-lumbosacral-fracture-due-to-sagittal-and-frontal-vertebral-imbalance
#2
L Boyoud-Garnier, M Boudissa, S Ruatti, G Kerschbaumer, P Grobost, J Tonetti
PROBLEM AND HYPOTHESIS: Over time, some patients with unilateral or bilateral lumbosacral injuries experience chronic low back pain. We studied the sagittal and frontal balance in a population with these injuries to determine whether mismatch in the pelvic and lumbar angles are associated with chronic low back pain. PATIENTS AND METHODS: Patients with posterior pelvic ring fractures (Tile C1, C2, C3 and A3.3) that had healed were included. Foreign patients and those with an associated spinal or acetabular fracture or nonunion were excluded...
March 19, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28326550/from-neuron-to-behavior-sensory-motor-coordination-of-zebrafish-turning-behavior
#3
REVIEW
Keiko Umeda, Wataru Shoji
Recent development of optogenetics brought non-invasive neural activation in living organisms. Transparent zebrafish larva is one of the suitable animal models for this technique, which enables us to investigate neural circuits for behaviors based on a whole individual nervous system. In this article we review our recent finding that suggests sensory-motor coordination in larval zebrafish escape behavior. When water vibration stimulates mechanosensory Rohon-Beard (RB) neurons, intra-spinal reflex circuit launches contralateral trunk muscle contraction that makes rapid body curvature for turning...
March 21, 2017: Development, Growth & Differentiation
https://www.readbyqxmd.com/read/28324184/early-outcomes-of-spinal-growth-tethering-for-idiopathic-scoliosis-with-a-novel-device-a-prospective-study-with-2-years-of-follow-up
#4
M Boudissa, A Eid, E Bourgeois, J Griffet, A Courvoisier
QUESTIONS/PURPOSES: Adolescent idiopathic scoliosis is a 3D spine deformity that worsens during the whole growth. New methods for spinal growth modulation with flexible spinal implants have been described to avoid progression of the deformity during growth spurt. The main limitations are that no specific ancillaries and devices are available, which makes the surgery technically demanding. METHODS: We have developed a new method of spinal growth tethering using minimal invasive videothoracoscopic approach...
March 21, 2017: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/28322758/increased-seat-dump-angle-in-a-manual-wheelchair-is-associated-with-changes-in-thoracolumbar-lordosis-and-scapular-kinematics-during-propulsion
#5
Beth A Cloud, Kristin D Zhao, Arin M Ellingson, Ahmad Nassr, Anthony J Windebank, Kai-Nan An
OBJECTIVE: To quantify and compare spinal curvature and shoulder kinematics throughout the manual wheelchair propulsion cycle for individuals with spinal cord injury (SCI) who were seated at 2 different seat dump angles. DESIGN: Single-group, repeated-measures study. SETTING: Academic medical center. PARTICIPANTS: Twenty-eight individuals completed the telephone screening; 21 were eligible and completed the study. INTERVENTIONS: Participants' personal manual wheelchairs were modified to have seat dump angles of 0° or 14°, with a vertical backrest...
March 18, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28290481/identification-of-elongated-primary-cilia-with-impaired-mechanotransduction-in-idiopathic-scoliosis-patients
#6
Niaz Oliazadeh, Kristen F Gorman, Robert Eveleigh, Guillaume Bourque, Alain Moreau
The primary cilium is an outward projecting antenna-like organelle with an important role in bone mechanotransduction. The capacity to sense mechanical stimuli can affect important cellular and molecular aspects of bone tissue. Idiopathic scoliosis (IS) is a complex pediatric disease of unknown cause, defined by abnormal spinal curvatures. We demonstrate significant elongation of primary cilia in IS patient bone cells. In response to mechanical stimulation, these IS cells differentially express osteogenic factors, mechanosensitive genes, and signaling genes...
March 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28277386/principal-radiographic-characteristics-for-cervical-spinal-deformity-a-health-related-quality-of-life-analysis
#7
Hongda Bao, Jeffrey Varghese, Renaud Lafage, Barthelemy Liabaud, Bassel Diebo, Subaraman Ramchandran, Louis Day, Cyrus Jalai, Dana Cruz, Thomas Errico, Themistocles Protopsaltis, Peter Passias, Aaron Buckland, Yong Qiu, Frank Schwab, Virginie Lafage
STUDY DESIGN: Retrospective study OBJECTIVE:: To propose radiographic characteristics of patients with cervical disability and to investigate the relevant parameters when assessing cervical alignment. SUMMARY OF BACKGROUND DATA: Although cervical kyphosis is traditionally recognized as presentation of cervical deformity, an increasing number of studies demonstrated that cervical kyphosis may not equal cervical deformity. Therefore, several other differentiating criteria for cervical deformity should be investigated and supported with quality of life scores...
March 8, 2017: Spine
https://www.readbyqxmd.com/read/28266959/morphometric-analysis-of-the-retroperitoneal-vessels-with-respect-to-lateral-access-surgery-in-adult-scoliosis
#8
Heeren S Makanji, Hai Le, Kirkham B Wood, Louis G Jenis, Thomas D Cha
STUDY DESIGN: Cross-sectional study reviewing 62 magnetic resonance imaging or computed tomography scans from consecutive adult patients with scoliotic spinal deformity in the thoracolumbar spine. OBJECTIVE: To investigate the variation in anatomic position of retroperitoneal vessels in relationship to curve direction, location, magnitude, and axial rotation of curves in adult scoliosis. SUMMARY OF BACKGROUND DATA: The minimally invasive lateral approach to the thoracolumbar spine avoids manipulation of abdominal and retroperitoneal structures and decreases risk of injury to paraspinal musculature...
March 6, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28248611/age-related-variations-in-global-spinal-alignment-and-sagittal-balance-in-asymptomatic-japanese-adults
#9
Kunio Yokoyama, Masahiro Kawanishi, Makoto Yamada, Hidekazu Tanaka, Yutaka Ito, Shinji Kawabata, Toshihiko Kuroiwa
OBJECTIVES: The global spinal sagittal alignment varies widely among healthy individuals as it is affected by not only race, but also aging. We investigated age-related changes in the spinal alignment in asymptomatic Japanese individuals. METHODS: The subjects comprised 220 individuals without any spine-related neurological symptoms or treatment history thereof who visited our outpatient clinic. Lateral radiographs of the whole spine were taken for all subjects in the standing position...
March 1, 2017: Neurological Research
https://www.readbyqxmd.com/read/28245271/association-between-vertebral-cross-sectional-area-and-lumbar-lordosis-angle-in-adolescents
#10
Tishya A L Wren, Patricia C Aggabao, Ervin Poorghasamians, Thomas A Chavez, Skorn Ponrartana, Vicente Gilsanz
Lumbar lordosis (LL) is more prominent in women than in men, but the mechanisms responsible for this discrepancy are poorly defined. A recent study indicates that newborn girls have smaller vertebral cross-sectional area (CSA) when compared to boys-a difference that persists throughout life and is independent of body size. We determined the relations between vertebral cross-sectional area (CSA) and LL angle and whether sex differences in lumbar lordosis are related to sex differences in vertebral CSA. Using multi-planar magnetic resonance imaging (MRI), we measured vertebral cross-sectional area (CSA) and vertebral height of the spine of 40 healthy boys and 40 girls, ages 9-13 years...
2017: PloS One
https://www.readbyqxmd.com/read/28244135/spinal-loading-patterns-from-biomechanical-modeling-explain-the-high-incidence-of-vertebral-fractures-in-the-thoracolumbar-region
#11
Alexander G Bruno, Katelyn Burkhart, Brett Allaire, Dennis E Anderson, Mary L Bouxsein
Vertebral fractures occur most frequently in the mid-thoracic and thoracolumbar regions of the spine, yet the reasons for this site-specific occurrence are not known. Our working hypothesis is that the locations of vertebral fracture may be explained by the pattern of spine loading, such that during daily activities the mid-thoracic and thoracolumbar regions experience preferentially higher mechanical loading compared to other spine regions. To test this hypothesis, we used a female musculoskeletal model of the full thoracolumbar spine and rib cage to estimate the variation in vertebral compressive loads and associated factor-of-risk (load-to-strength ratio) throughout the spine for 119 activities of daily living, while also parametrically varying spine curvature (high, average, low, and zero thoracic kyphosis models)...
February 27, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28241724/-clinical-analysis-of-cervical-posterior-internal-fixation-titanium-plate-and-silk-suspension-internal-fixation-cervical-spondylosis
#12
X N Xu, H Y Liu
Objective: To evaluate the clinical effect and imaging evaluation of cervical spine myelopathy treated with Centerpiece. Methods: A retrospective study of 60 patients underwent posterior cervical spine surgery because of cervical myelopathy in Spinal Department of Peking University People's Hospital from July 2011 to January 2013.According to the different fixation methods, all patients were divided into cervical posterior open-door Centerpiece fixation group (group A) and cervical posterior open-door silk suspension fixation group (group B)...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28241716/-effect-analysis-of-anterior-cervical-operation-for-severe-cervical-kyphosis
#13
X L Shen, H Q Wu, Z H Hu, Y Liu, X W Wang, H J Chen, P Cao, Y Tian, C Yang, W Yuan
Objective: To determine the feasibility and safety of anterior cervical decompression and fusion in severe cervical kyphosis treatment. Methods: Totally 29 patients with severe cervical kyphosis(Cobb angle>50°) underwent anterior cervical decompression and fusion from June 2008 to May 2016 were studied retrospectively. There were 19 males and 10 females. The average age was 32.6 years ranging from 14 to 53 years. According to the etiology, 12 patients had iatrogenic deformity (11 had post-laminectomy cervical kyphosis, 1 had kyphosis due to anterior graft subsidence), 5 had neurofibromatosis, 4 had infective kyphosis, 8 had idiopathic cervical kyphosis...
March 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28195302/testing-biomechanical-models-of-human-lumbar-lordosis-variability
#14
Eric R Castillo, Connie Hsu, Ross W Mair, Daniel E Lieberman
OBJECTIVES: Lumbar lordosis (LL) is a key adaptation for bipedalism, but factors underlying curvature variations remain unclear. This study tests three biomechanical models to explain LL variability. MATERIALS AND METHODS: Thirty adults (15 male, 15 female) were scanned using magnetic resonance imaging (MRI), a standing posture analysis was conducted, and lumbar range of motion (ROM) was assessed. Three measures of LL were compared. The trunk's center of mass was estimated from external markers to calculate hip moments (Mhip ) and lumbar flexion moments...
February 13, 2017: American Journal of Physical Anthropology
https://www.readbyqxmd.com/read/28180978/3d-rod-shape-changes-in-adolescent-idiopathic-scoliosis-instrumentation-how-much-does-it-impact-correction
#15
Franck Le Navéaux, Carl-Eric Aubin, Stefan Parent, Peter O Newton, Hubert Labelle
PURPOSE: Flattening of rods is known to reduce the correction capability of the instrumentation, but has not been studied in 3D. The aim is to evaluate the rods shape 3D changes during and immediately after instrumentation, and its effect on 3D correction. METHODS: The 5.5 mm CoCr rods of 35 right thoracic adolescent idiopathic scoliosis patients were measured from rod tracings prior to insertion, and reconstructed in 3D from bi-planar radiographs taken intra-operatively after the correction maneuvers and 1 week post-operatively...
February 8, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28174019/understanding-idiopathic-scoliosis-a-new-zebrafish-school-of-thought
#16
REVIEW
Curtis W Boswell, Brian Ciruna
Idiopathic scoliosis (IS) refers to a 3D rotation of the spine that occurs in the absence of underlying vertebral anomalies or obvious physiological defects. Despite affecting approximately 4% of the population, the etiology and pathogenesis of IS remain poorly understood, largely due to genetic heterogeneity and historical lack of appropriate developmental models. Recently, zebrafish has emerged as a powerful system for studying IS, owing to well-developed genetic resources and a natural susceptibility to spinal curvatures...
February 4, 2017: Trends in Genetics: TIG
https://www.readbyqxmd.com/read/28161236/minimally-invasive-decompression-surgery-for-lumbar-spinal-stenosis-with-degenerative-scoliosis-predictive-factors-of-radiographic-and-clinical-outcomes
#17
Akihito Minamide, Munehito Yoshida, Hiroki Iwahashi, Andrew K Simpson, Hiroshi Yamada, Hiroshi Hashizume, Yukihiro Nakagawa, Hiroshi Iwasaki, Shunji Tsutsui, Ryohei Kagotani, Mayumi Sonekatsu, Takahide Sasaki, Kazunori Shinto, Tsuyoshi Deguchi
There is ongoing controversy regarding the most appropriate surgical treatment for lumbar spinal stenosis (LSS) with concurrent degenerative lumbar scoliosis (DLS): decompression alone, decompression with limited spinal fusion, or long spinal fusion for deformity correction. The coexistence of degenerative stenosis and deformity is a common scenario; Nonetheless, selecting the appropriate surgical intervention requires thorough understanding of the patients clinical symptomatology as well as radiographic parameters...
February 1, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28155829/activity-of-dr-j%C3%A3-zef-aleksiewicz-phd-towards-the-development-of-orthopedics-and-rehabilitation-in-lviv-in-the-years-1912-1930
#18
Sławomir Jandziś, Stanisław Zaborniak
The article describes the work of Dr Aleksiewicz towards the development of orthopedics and rehabilitation in Lviv in the years 1912-1930 based on source materials belonging to his family and articles published in medical journals and daily press. In 1919, Dr Aleksiewicz established a Surgical and Orthopedic Department and a factory of prostheses at the Disabled House in Lviv. He also formed a 200-bed division for the visually impaired with basket- and comb-making workshops as well as massage and typing courses...
March 23, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28139008/oxidative-stress-mediated-developmental-toxicity-induced-by-isoniazide-in-zebrafish-embryos-and-larvae
#19
Yu Zou, Yun Zhang, Liwen Han, Qiuxia He, Hairong Hou, Jian Han, Ximin Wang, Chengyun Li, Juan Cen, Kechun Liu
Isoniazide (INH) is an important first-line drug that is used to treat tuberculosis. However, the effect of INH on fetal growth has not yet been elucidated, and the mechanism of INH-induced developmental toxicity is still unknown. In the present study, we employed zebrafish embryos and larvae to investigate the developmental toxicity of INH. The survival rates of the embryos and larvae as well as the hatching rates of embryos were significantly reduced. Morphological abnormalities, including spinal curvature, yolk retention, swimming bladder absence, tail bending and shorter body lengths were induced by INH...
January 31, 2017: Journal of Applied Toxicology: JAT
https://www.readbyqxmd.com/read/28130805/topologically-preserving-straightening-of-spinal-cord-mri
#20
Benjamin De Leener, Gabriel Mangeat, Sara Dupont, Allan R Martin, Virginie Callot, Nikola Stikov, Michael G Fehlings, Julien Cohen-Adad
PURPOSE: To propose a robust and accurate method for straightening magnetic resonance (MR) images of the spinal cord, based on spinal cord segmentation, that preserves spinal cord topology and that works for any MRI contrast, in a context of spinal cord template-based analysis. MATERIALS AND METHODS: The spinal cord curvature was computed using an iterative Non-Uniform Rational B-Spline (NURBS) approximation. Forward and inverse deformation fields for straightening were computed by solving analytically the straightening equations for each image voxel...
January 27, 2017: Journal of Magnetic Resonance Imaging: JMRI
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