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Antithrombin III

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https://www.readbyqxmd.com/read/28060110/antithrombin-iii-as-the-indicator-of-l-asparaginase-activity-in-children-treated-for-acute-lymphoblastic-leukemia
#1
Małgorzata Czogała, Walentyna Balwierz, Krystyna Sztefko, Iwona Rogatko
L-asparaginase (ASP) is widely used in the treatment of acute lymphoblastic leukemia (ALL) in children. Monitoring its activity is necessary because of the risk of drug inactivation as the result of an immune reaction. Besides allergic reactions, another frequent side effect of ASP treatment is coagulopathy, especially deficiency of antithrombin III (ATIII). The aim of this study was to analyze the relationship between ASP and ATIII activities and the possibility of ATIII activity use in an indirect ASP activity assessment...
January 5, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/28039291/can-recombinant-human-thrombomodulin-increase-survival-among-patients-with-severe-septic-induced-disseminated-intravascular-coagulation-a-single-centre-open-label-randomised-controlled-trial
#2
Akiyoshi Hagiwara, Noriko Tanaka, Tatsuki Uemura, Wataru Matsuda, Akio Kimura
OBJECTIVE: To determine whether treatment with recombinant human thrombomodulin (rhTM) increases survival among patients with severe septic-induced disseminated intravascular coagulation (DIC). DESIGN: Single-centre, open-label, randomised controlled trial. SETTING: Single tertiary hospital. PARTICIPANT: 92 patients with severe septic-induced DIC. INTERVENTIONS: Patients with DIC scores ≥4, as defined by the Japanese Association of Acute Medicine, were diagnosed with DIC...
December 30, 2016: BMJ Open
https://www.readbyqxmd.com/read/28036282/sulodexide-pretreatment-attenuates-renal-ischemia-reperfusion-injury-in-rats
#3
Jianyong Yin, Weibin Chen, Fenfen Ma, Zeyuan Lu, Rui Wu, Guangyuan Zhang, Niansong Wang, Feng Wang
Sulodexide is a potent antithrombin agent, however, whether it has beneficial effects on renal ischemia-reperfusion injury (IRI) remains unknown. In the present study, we assessed the therapeutic effects of sulodexide in renal IRI and tried to investigate the potential mechanism. One dose of sulodexide was injected intravenously in Sprague-Dawley rats 30 min before bilateral kidney ischemia for 45 min. The animals were sacrificed at 3h and 24h respectively. Our results showed that sulodexide pretreatment improved renal dysfunction and alleviated tubular pathological injury at 24h after reperfusion, which was accompanied with inhibition of oxidative stress, inflammation and cell apoptosis...
December 27, 2016: Oncotarget
https://www.readbyqxmd.com/read/28007564/structural-analysis-of-heparin-derived-3-o-sulfated-tetrasaccharides-antithrombin-binding-site-variants
#4
Yin Chen, Lei Lin, Isaac Agyekum, Xing Zhang, Kalib St Ange, Yanlei Yu, Fuming Zhang, Jian Liu, I Jonathan Amster, Robert J Linhardt
Heparin is a polysaccharide that is widely used as an anticoagulant drug. The mechanism for heparin's anticoagulant activity is primarily through its interaction with a serine protease inhibitor, antithrombin III (AT), that enhances its ability to inactivate blood coagulation serine proteases, including thrombin (factor IIa) and factor Xa. The AT-binding site in the heparin is one of the most well-studied carbohydrate-protein binding sites and its structure is the basis for the synthesis of the heparin pentasaccharide drug, fondaparinux...
December 20, 2016: Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28005013/antithrombin-iii-deficiency-concomitant-with-atrial-fibrillation-causes-thrombi-in-all-chambers-2d-and-3d-echocardiographic-evaluation
#5
Mert İlker Hayıroğlu, Muhammed Keskin, Cevdet Dönmez, Muhammed Burak Günay, Şennur Ünal Dayı
No abstract text is available yet for this article.
December 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/28000366/hemocompatiblilty-evaluation-of-poly-1-8-octanediol-citrate-blend-polyethersulfone-membranes
#6
Muhamad Zulhilmi Zailani, Ahmad Fauzi Ismail, Siti Hamimah Sheikh Abdul Kadir, Mohd Hafiz Dzarfan Othman, Pei Sean Goh, Hasrinah Hasbullah, Mohd Sohaimi Abdullah, Be Cheer Ng, Fatmawati Kamal
In this study, poly (1,8- octanediol citrate) (POC) was used to modify polyethersufone (PES) based membrane to enhance its hemocompatibility. Different compositions of POC (0-3%) were added into the polyethersulfone (PES) dope solutions and polyvinylpyrrolidone (PVP) was used as pore forming agent. The hemocompatible POC modified PES membranes were fabricated through phase-inversion technique. The prepared membranes were characterized using attenuated total reflectance-fourier transform infrared (ATR-FTIR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Atomic-force microscopy (AFM), contact angle, Zeta-potential, membrane porosity and pore size and pure water flux (PWF) and BSA rejection...
December 21, 2016: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/27993201/antithrombin-iii-improved-neutrophil-extracellular-traps-in-lung-after-the-onset%C3%A2-of%C3%A2-endotoxemia
#7
Michiko Ishikawa, Hayato Yamashita, Nobuki Oka, Takahiro Ueda, Keisuke Kohama, Atsunori Nakao, Joji Kotani
BACKGROUND: Coagulation and inflammation are closely linked during acute inflammatory conditions, such as sepsis. Antithrombin (AT) is an anticoagulant that also has anti-inflammatory activities. The effects of therapeutically administering AT III after the onset of endotoxemia or sepsis were not clear. Here, we studied the effects of administering AT III after inducing lethal endotoxemia in mice. METHODS: Mice were injected intraperitoneally with lipopolysaccharide (LPS) to induce endotoxemia...
February 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/27898408/sulodexide-protects-contrast-induced-nephropathy-in-sprague-dawley-rats
#8
Qing Zhao, Jianyong Yin, Zeyuan Lu, Yiwei Kong, Guangyuan Zhang, Binghui Zhao, Feng Wang
BACKGROUND: Sulodexide is a powerful antithrombin agent with reno-protective property. However, whether it has beneficial effects on Contrast-Induced Nephropathy (CIN) remained elusive. In the current study, we evaluated the therapeutic effects of Sulodexide on CIN and investigated the potential mechanisms. METHODS: CIN model was induced by intravenous injection of indomethacin, followed by Ioversol and L-NAME. Sprague-Dawley rats were divided into 4 groups: control group, CIN group, CIN+vehicle group (CIN rats pretreated with vehicle) and CIN+ Sulodexide (CIN rats pretreated with Sulodexide)...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27894965/an-application-of-mass-spectrometry-for-quality-control-of-biologicals-highly-sensitive-profiling-of-plasma-residuals-in-human-plasma-derived-immunoglobulin
#9
Franck Limonier, Katleen Van Steendam, Geneviève Waeterloos, Koen Brusselmans, Myriam Sneyers, Dieter Deforce
: Thromboembolic events (TEE) associated to trace amounts of plasmatic activated coagulation factor XI (FXIa) in administrated immunoglobulin (Ig) have recently raised concerns and hence there is a need for highly sensitive profiling of residual plasma source proteins. This study aims to consider LC-ESI-QTOF data-dependent acquisition in combination with sample fractionation for this purpose. Sample fractionation proved mandatory to enable identification of plasma residuals. Two approaches were compared: Ig depletion with protein G - protein A affinity chromatography and low-abundant protein enrichment with a combinatorial peptide ligand library (ProteoMiner™, Bio-Rad)...
January 30, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/27861430/the-use-of-recombinant-antithrombin-iii-in-pediatric-and-neonatal-ecmo-patients
#10
Deanna R Todd Tzanetos, John Myers, Terri Wells, Dan Stewart, Jeffrey J Fanning, Janice E Sullivan
A retrospective review of 77 pediatric and neonatal extracorporeal membranous oxygenation (ECMO) patients who received recombinant antithrombin III (ATIII) for ATIII activity greater than 80% was conducted. Anticoagulation management was per institutional protocol. An ATIII activity greater than 80% was targeted. Diagnosis, reason for ECMO cannulation, blood product usage, heparin dosing, ATIII activity and doses, thrombotic and bleeding complications, hours on ECMO, and mortality were recorded. We calculated patient-level summary statistics and assessed differences between groups using χ tests (categorical variables) and Wilcoxon rank sum tests (continuous variables)...
January 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27853070/edoxaban-was-effective-for-the-treatment-of-deep-vein-thrombosis-and-pulmonary-thromboembolism-in-a-cancer-patient-with-antithrombin-iii-deficiency
#11
Hiroaki Kawano, Koji Maemura
A 57-year-old man with antithrombin III deficiency with deep vein thrombosis and pulmonary thromboembolism after surgery for colon cancer was managed with warfarin and inferior vena cava filtration. After starting chemotherapy for liver metastasis, the control of his prothrombin time-international normalized ratio in response to warfarin began to fluctuate. Warfarin was changed to edoxaban (an oral direct Factor Xa inhibitor), and he had no recurrence of venous thromboembolism or bleeding for approximately 1 year...
2016: Internal Medicine
https://www.readbyqxmd.com/read/27851127/1491-antithrombin-iii-deficiency-relates-to-mortality-in-sepsis
#12
Noriko Saito, Ayumi Kawasaki, Noboru Akizuki, Mizuho Namiki, Munekazu Takeda, Arino Yaguchi
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27850493/855-antithrombin-iii-supplementation-for-pediatric-patients-on-ecmo-and-heparin-anticoagulation
#13
Caroline Heyrend, Jared Olson, Chanelle Stidham, Brent Kay
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27847121/outcomes-following-routine-antithrombin-iii-replacement-during-neonatal-extracorporeal-membrane-oxygenation
#14
Brian K Stansfield, Linda Wise, P Benson Ham, Pinkal Patel, Malinda Parman, Chan Jin, Sunil Mathur, Gregory Harshfield, Jatinder Bhatia
BACKGROUND: We sought to examine the effect of routine antithrombin III (AT3) infusion on hemorrhagic and thrombotic complications, blood product utilization, and circuit lifespan in neonatal extracorporeal membrane oxygenation (ECMO). METHODS: We performed a retrospective cohort study of 162 infants placed on ECMO for hypoxic respiratory failure. Infants requiring ECMO for primary cardiac support were excluded. Demographic data, time on ECMO, blood product usage, coagulation profile, and complications were compared between 90 control patients and 72 patients treated with AT3...
October 30, 2016: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/27799851/low-molecular-weight-heparin-can-benefit-women-with-recurrent-pregnancy-loss-and-sole-protein-s-deficiency-a-historical-control-cohort-study-from-taiwan
#15
Ming-Ching Shen, Wan-Ju Wu, Po-Jen Cheng, Gwo-Chin Ma, Wen-Chu Li, Jui-Der Liou, Cheng-Shyong Chang, Wen-Hsiang Lin, Ming Chen
BACKGROUND: Heritable thrombophilias are assumed important etiologies for recurrent pregnancy loss. Unlike in the Caucasian populations, protein S and protein C deficiencies, instead of Factor V Lieden and Prothrombin mutations, are relatively common in the Han Chinese population. In this study we aimed to investigate the therapeutic effect of low molecular weight heparin upon women with recurrent pregnancy loss and documented protein S deficiency. METHODS: During 2011-2016, 68 women with recurrent pregnancy loss (RPL) and protein S deficiency (both the free antigen and function of protein S were reduced) were initially enrolled...
2016: Thrombosis Journal
https://www.readbyqxmd.com/read/27795523/diagnosis-and-management-of-dic-complicated-by-hematological-malignancies
#16
Takayuki Ikezoe
The clinical features noted in individuals with disseminated intravascular coagulation (DIC) complicated by hematological malignancies include life threatening hemorrhage that is associated with thrombocytopenia and consumptive deficiency of coagulation factors. Exacerbation of DIC after the initiation of chemotherapy is also related to fatal hemorrhage. The Japanese Society of Thrombosis and Hemostasis recently proposed provisional DIC diagnostic criteria allowing evaluation of hypercoagulable markers such as soluble fibrin and thrombin-antithrombin complex to help physicians to diagnose DIC and initiate treatment in the early phase of coagulopathy...
2016: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/27790498/massive-pulmonary-embolism-in-a-patient-using-warfarin-at-therapeutic-dose
#17
Sunnetcioglu Aysel, Esen Ramazan, Arisoy Ahmet
Warfarin sodium is commonly used for the prevention and treatment of thromboembolism. The efficacy of warfarin therapy depends on maintaining the International Normalised Ratio (INR) within the target range for the indication. A 56-year-old male presented to the emergency department with dyspnea and chest pain, together with pain and swelling in both legs. The patient had been taking warfarin at the therapeutic dose since having undergone an aortic valve replacement four years ago. His vital signs were an arterial pressure of 60/30 heart rate of 138 beats per minute, respiratory rate of 30 per minute and oxygen saturation of 60%...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27765880/evaluating-the-potential-of-routine-blood-tests-to-identify-the-risk-of-deep-vein-thrombosis-a-1-year-monocenter-cohort-study
#18
Salvatore Santo Signorelli, Fiore Valerio, Castrogiovanni Davide, Gea Oliveri Conti, Fiore Maria, Morana Ignazio, Ferrante Margherita
Study on 295 consecutive medical patients to evaluate the potential of routine blood tests to identify the risk of deep vein thrombosis (DVT). The tests included in a DVT risk stratification model system were erythrocyte sedimentation rate, antithrombin III, C-reactive protein, D-dimer, and N-terminal pro-brain natriuretic peptide. The DVT risk stratification system was moderately prognostic (area under the curve: 0.838; 95% confidence interval: 0.771-0.904; P < .001), whereas its performance was as follows-sensitivity, 100%; specificity, 20%; positive predictive value, 21%; and negative predictive value, 100%...
October 20, 2016: Angiology
https://www.readbyqxmd.com/read/27762592/fibrin-nanostructures-for-biomedical-applications
#19
Z Riedelová-Reicheltová, E Brynda, T Riedel
Fibrin is a versatile biopolymer that has been extensively used in tissue engineering. In this paper fibrin nanostructures prepared using a technique based on the catalytic effect of fibrin-bound thrombin are presented. This technique enables surface-attached thin fibrin networks to form with precisely regulated morphology without the development of fibrin gel in bulk solution. Moreover, the influence of changing the polymerization time, along with the antithrombin III and heparin concentrations on the morphology of fibrin nanostructures was explored...
October 20, 2016: Physiological Research
https://www.readbyqxmd.com/read/27749296/massive-fulminant-thrombosis-during-liver-transplantation-in-a-patient-with-a-previously-unknown-antithrombin-pathway-mutation
#20
Dmitri Bezinover, Shigekazu Sugino, Yuka Imamura-Kawasawa, Matthew S Bell, Zakiyah Kadry, Piotr K Janicki
We describe a case of fulminant intraoperative thrombosis during deceased donor liver transplantation. Despite significant medical bleeding, the patient suddenly developed diffuse thrombosis in all chambers of the heart and pulmonary vasculature resulting in intraoperative death. The patient's postmortem genetic analysis demonstrated a deleterious missense mutation in a coagulation pathway gene, SERPINC1, which codes for antithrombin III. The level of antithrombin III was not available to directly prove the causality of thrombosis, but our findings suggest that this mutation, in combination with antifibrinolytic administration in a hypercoagulable cirrhotic patient, might have contributed to the development of this catastrophic thrombotic event...
December 1, 2016: A & A Case Reports
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