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https://www.readbyqxmd.com/read/27697453/the-functional-analysis-of-distinct-tospovirus-movement-proteins-nsm-reveals-different-capabilities-in-tubule-formation-cell-to-cell-and-systemic-virus-movement-among-the-tospovirus-species
#1
Mikhail O Leastro, Vicente Pallás, Renato O Resende, Jesús A Sánchez-Navarro
The lack of infectious tospovirus clones to address reverse genetic experiments has compromised the functional analysis of viral proteins. In the present study we have performed a functional analysis of the movement proteins (NSM) of four tospovirus species Bean necrotic mosaic virus (BeNMV), Chrysanthemum stem necrosis virus (CSNV), Tomato chlorotic spot virus (TCSV) and Tomato spotted wilt virus (TSWV), which differ biologically and molecularly, by using the Alfalfa mosaic virus (AMV) model system. All NSM proteins were competent to: i) support the cell-to-cell and systemic transport of AMV, ii) generate tubular structures on infected protoplast and iii) transport only virus particles...
January 2, 2017: Virus Research
https://www.readbyqxmd.com/read/27604673/inferior-vena-cava-resection-and-reconstruction-for-tumoral-recurrence-after-right-nephrectomy
#2
Pv-H Botianu, R Chirtes, C Marcu, H Kosza, M Stoian, O Brusnic, Amv Botianu, A Dobre
We report a 60 years old patient who was admitted for a local recurrence after a right nephrectomy performed 2 years ago (papillary renal carcinoma with areas of sarcomatoid differentiation - pT3a). CT scan showed a retroperitoneal mass with invasion of the inferior vena cava. We performed a complete en-bloque excision of the tumor with the infrarenal portion of the inferior vena cava and lympha-denectomy. The vascular reconstruction was performed by the interposition of a 20 mm diameter Dacron prosthesis. The postoperative course was complicated due to an episode of digestive bleeding (duodenal ulcer) which stopped after conservative treatment (antisecretory and hemostatics, including rFVIIa), but eventually favourable...
July 2016: Chirurgia
https://www.readbyqxmd.com/read/27494171/a-comparison-study-of-single-echo-susceptibility-weighted-imaging-and-combined-multi-echo-susceptibility-weighted-imaging-in-visualizing-asymmetric-medullary-veins-in-stroke-patients
#3
Chao Wang, Tiantian Qiu, Ruirui Song, Yerfan Jiaerken, Linglin Yang, Shaoze Wang, Minming Zhang, Xinfeng Yu
BACKGROUND: Asymmetric medullary veins (AMV) are frequently observed in stroke patients and single-echo susceptibility weighted imaging (SWIs) is the main technique in detecting AMV. Our study aimed to investigate which echo time (TE) on single-echo susceptibility is the optimal echo for visualizing AMV and to compare the ability in detecting AMV in stroke patients between SWIs and multi-echo susceptibility weighted imaging (SWIc). MATERIALS AND METHODS: Twenty patients with middle cerebral artery stroke were included...
2016: PloS One
https://www.readbyqxmd.com/read/27471367/latent-left-ventricular-outflow-tract-obstruction-due-to-accessory-mitral-valve-in-a-12-year-old-boy
#4
Kyung Won Yun, Yong Hyun Park, Sang Hyun Lee, Jeong Su Kim, June Hong Kim, Kook Jin Chun
Accessory mitral valve (AMV) is a rare congenital anomaly which can cause left ventricular outflow tract (LVOT) obstruction. Patients with isolated AMV usually present with exertional dyspnea, chest pain, or syncope during the first ten years of life. In patients with AMV, detection of latent LVOT obstruction can be clinically challenging. We here present a case of AMV causing latent LVOT obstruction in an adolescent, which was diagnosed by echocardiography with dobutamine provocation and finally treated by successful surgical resection...
July 2016: Acta Cardiologica Sinica
https://www.readbyqxmd.com/read/27430471/endovascular-treatment-of-arteriovenous-malformations
#5
Orlando Diaz, Robert Scranton
Cerebral arteriovenous malformations (AVM) are tangles of blood vessels that permit shunting of blood from the arterial to venous phase without intervening capillaries. The malformation's arterialization of a low-pressure system creates a risk of rupture that is substantially higher when associated with an aneurysm. The annual hemorrhage rate is 2.2% per year as reported in the randomized trial of unruptured brain AVMs (ARUBA; rupture risk is increased after the first event. Ruptured AVMs have a 10% mortality rate and 20%-30% morbidity rate...
2016: Handbook of Clinical Neurology
https://www.readbyqxmd.com/read/27323147/a-single-nucleotide-polymorphism-in-gabaa-receptor-isoforms-is-potentially-responsible-for-isoflurane-sensitivity-in-mice
#6
X Wang, Z G Song, D X Huang, H Gao, Q Wang, Z P Wang
GABAA receptors are chloride channels in the brain that are activated by binding with g-aminobutyric acid (GABA). The cDNA sequences of GABAA receptor subunits from two strains of mice with different sensitivities to isoflurane were compared to identify nucleotide mutations. Included 80 mice from two strains with different sensitivities to isoflurane on C57BL/6 background. Forty mice were from an isoflurane-sensitive strain (S group) and 40 mice were from a resistant strain (R group). RNA was extracted from brains of the mice, and cDNA were reverse transcribed using AMV reverse transcriptase...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27235428/anaplasma-marginale-actively-modulates-vacuolar-maturation-during-intracellular-infection-of-its-tick-vector-dermacentor-andersoni
#7
Forgivemore Magunda, Chelsea Wright Thompson, David A Schneider, Susan M Noh
UNLABELLED: Tick-borne transmission of bacterial pathogens in the order Rickettsiales is responsible for diverse infectious diseases, many of them severe, in humans and animals. Transmission dynamics differ among these pathogens and are reflected in the pathogen-vector interaction. Anaplasma marginale has been shown to establish and maintain infectivity within Dermacentor spp. for weeks to months while escaping the complex network of vacuolar peptidases that are responsible for digestion of the tick blood meal...
August 1, 2016: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/26973816/the-pathogen-occupied-vacuoles-of-anaplasma-phagocytophilum-and-anaplasma-marginale-interact-with-the-endoplasmic-reticulum
#8
Hilary K Truchan, Chelsea L Cockburn, Kathryn S Hebert, Forgivemore Magunda, Susan M Noh, Jason A Carlyon
The genus Anaplasma consists of tick-transmitted obligate intracellular bacteria that invade white or red blood cells to cause debilitating and potentially fatal infections. A. phagocytophilum, a human and veterinary pathogen, infects neutrophils to cause granulocytic anaplasmosis. A. marginale invades bovine erythrocytes. Evidence suggests that both species may also infect endothelial cells in vivo. In mammalian and arthropod host cells, A. phagocytophilum and A. marginale reside in host cell derived pathogen-occupied vacuoles (POVs)...
2016: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/26951288/a-role-for-the-anteromedial-thalamic-nucleus-in-the-acquisition-of-contextual-fear-memory-to-predatory-threats
#9
Miguel Antonio Xavier de Lima, Marcus Vinicius C Baldo, Newton Sabino Canteras
Previous studies from our group have shown that cytotoxic lesions in the ventral portion of the anteromedial thalamic nucleus (AMv), one of the main targets of the hypothalamic predator-responsive circuit, strongly impairs contextual fear responses to an environment previously associated with a predator. The AMv is in a position to convey information to cortico-hippocampal-amygdalar circuits involved in the processing of fear memory. However, it remains to be determined whether the nucleus is involved in the acquisition or subsequent expression of contextual fear...
March 7, 2016: Brain Structure & Function
https://www.readbyqxmd.com/read/26929142/the-coat-protein-of-alfalfa-mosaic-virus-interacts-and-interferes-with-the-transcriptional-activity-of-the-bhlh-transcription-factor-ilr3-promoting-salicylic-dependent-defense-signaling-response
#10
Frederic Aparicio, Vicente Pallás
During virus infection, the specific viral components-host factors interaction elicits transcriptional reprogramming of diverse cellular pathways. Alfalfa mosaic virus (AMV) establishes a compatible interaction in tobacco and Arabidopsis hosts. We show that the coat protein (CP) of AMV directly interacted with transcription factor (TF) ILR3 of both species. ILR3 is a basic helix-loop-helix (bHLH) family member of TFs, previously proposed to participate in diverse metabolic pathways. ILR3 has been shown to regulate NEET in Arabidopsis, a critical protein in plant development, senescence, iron metabolism and reactive oxygen species (ROS) homeostasis...
February 29, 2016: Molecular Plant Pathology
https://www.readbyqxmd.com/read/26788935/cerebrospinal-fluid-velocity-amplitudes-within-the-cerebral-aqueduct-in-healthy-children-and-patients-with-chiari-i-malformation
#11
J Rajiv Bapuraj, Frank J Londy, Nader Delavari, Cormac O Maher, Hugh J L Garton, Bryn A Martin, Karin M Muraszko, El-Sayed H Ibrahim, Douglas J Quint
PURPOSE: To assess the effects of cerebrospinal fluid (CSF) bidirectional motion in Chiari malformation type I (CMI), we monitored CSF velocity amplitudes on phase contrast MRI (PC-MRI) in patients before and after surgery; and in healthy volunteers. MATERIALS AND METHODS: 10 pediatric volunteers and 10 CMI patients participated in this study. CMI patients underwent PC-MRI scans before and approximately 14 months following surgery. Two parameters-amplitude of mean velocity (AMV) and amplitude of peak velocity (APV) of CSF-were derived from the data...
August 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/26593402/remote-influence-of-atlantic-multidecadal-variability-on-siberian-warm-season-precipitation
#12
Cheng Sun, Jianping Li, Sen Zhao
The time series of 20th century Siberian warm season (May to October) precipitation (SWP) shows variations over decadal timescales, including a wetting trend since the 1970s. Here, it is shown that the Atlantic multidecadal variability (AMV) can be implicated as a remote driver of the decadal-scale variations in SWP. Observational analysis identifies a significant in-phase relationship between the AMV and SWP, and the SWP decadal variability can be largely explained by the AMV. The physical mechanism for this relationship is investigated using both observations and numerical simulations...
2015: Scientific Reports
https://www.readbyqxmd.com/read/26470967/how-better-is-random-blinded-re-checking-results-in-revised-national-tb-control-programme-india
#13
B N Sharath, Amv Kumar, R Ranjini, S Anand, H Sundaram, S K Singh, P Kumar
BACKGROUND: The Revised National Tuberculosis Control Programme (RNTCP) is implementing the External Quality assurance (EQA) and Random blinded re-checking (RBRC) as one of its important component. This nationwide study was conducted to determine (1) the number and types of RBRC errors and (2) the sensitivity and specificity among rechecked slides. MATERIALS AND METHODS: The study was based on the monthly RBRC reports submitted by ~13,000 designated microscopy centres (DMCs) across the country under routine programmatic settings in 2010...
October 2015: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/26458128/-determination-of-hypercapnic-ventilatory-response-in-copd-patients
#14
K Sohrabi, M Scholtes, L Mursina, A Weissflog, W Hildebrandt, O Hildebrandt, V Gross, U Koehler
Previous studies showed a reduced hypercapnic ventilatory response (HCVR) in patients with COPD. However, the association between HCVR and COPD GOLD stages is unknown. The measurement of the HCVR is a methodological option to test the function of the breathing feedback cycle. The aim of this feasibility study was to present a new automatic and standardized device (MATAM) to measure and interpret the HCVR. This device determines if exposure to CO2 leads to an adequate increase in breathing frequency and tidal volume...
November 2015: Pneumologie
https://www.readbyqxmd.com/read/26095193/a-fluorescent-adenosine-analogue-as-a-substrate-for-an-a-to-i-rna-editing-enzyme
#15
Rena A Mizrahi, Dongwon Shin, Renatus W Sinkeldam, Kelly J Phelps, Andrea Fin, Dean J Tantillo, Yitzhak Tor, Peter A Beal
Adenosine to inosine RNA editing catalyzed by ADAR enzymes is common in humans, and altered editing is associated with disease. Experiments using substrate RNAs with adenosine analogues at editing sites are useful for defining features of the ADAR reaction mechanism. The reactivity of ADAR2 was evaluated with RNA containing the emissive adenosine analogue thieno[3,4-d]-6-aminopyrimidine ((th)A). This nucleoside was incorporated into a mimic of the glutamate receptor B (GluR B) mRNA R/G editing site. We found that (th)A is recognized by AMV reverse transcriptase as A, and is deaminated rapidly by human ADAR2 to give (th)I...
July 20, 2015: Angewandte Chemie
https://www.readbyqxmd.com/read/25959333/a-field-study-on-thermal-comfort-in-an-italian-hospital-considering-differences-in-gender-and-age
#16
S Del Ferraro, S Iavicoli, S Russo, V Molinaro
The hospital is a thermal environment where comfort must be calibrated by taking into account two different groups of people, that is, patients and medical staff. The study involves 30 patients and 19 medical staff with a view to verifying if Predicted Mean Vote (PMV) index can accurately predict thermal sensations of both groups also taking into account any potential effects of age and gender. The methodology adopted is based on the comparison between PMV values (calculated according to ISO 7730 after having collected environmental data and estimated personal parameters) and perceptual judgments (Actual Mean Vote, AMV), expressed by the subjects interviewed...
September 2015: Applied Ergonomics
https://www.readbyqxmd.com/read/25849958/asymmetry-of-deep-medullary-veins-on-susceptibility-weighted-mri-in-patients-with-acute-mca-stroke-is-associated-with-poor-outcome
#17
Johanna Mucke, Markus Möhlenbruch, Philipp Kickingereder, Pascal J Kieslich, Philipp Bäumer, Christoph Gumbinger, Jan Purrucker, Sibu Mundiyanapurath, Heinz-Peter Schlemmer, Martin Bendszus, Alexander Radbruch
BACKGROUND AND PURPOSE: Due to its sensitivity to deoxyhemoglobin, susceptibility weighted imaging (SWI) enables the visualization of deep medullary veins (DMV) in patients with acute stroke, which are difficult to depict under physiological circumstances. This study assesses the asymmetric appearance of prominent DMV as an independent predictor for stroke severity and outcome. MATERIALS AND METHODS: SWI of 86 patients with acute middle cerebral artery (MCA) stroke were included...
2015: PloS One
https://www.readbyqxmd.com/read/25834804/alteration-of-laboratory-findings-after-radiofrequency-ablation-of-hepatocellular-carcinoma-relationship-to-severity-of-the-underlying-liver-disease-and-the-ablation-volume
#18
Sang-Wook Shin, Woo Kyoung Jeong, Sanghyeok Lim, Yongsoo Kim, Jinoo Kim
BACKGROUND/AIMS: To investigate sequential changes in laboratory markers after radiofrequency ablation (RFA) of hepatocellular carcinoma (HCC) and the relationship of these changes to the severity of the underlying liver disease. METHODS: This retrospective analysis included 65 patients (44 males, 21 females) who underwent RFA of HCC. Hematologic and biochemical markers were assessed at the pre-RFA period and 1 day, 2-3 days, and 1-2 weeks after RFA. We classified the subjects into two groups: Child-Pugh A (n=41) and Child-Pugh B (n=24)...
March 2015: Clinical and Molecular Hepatology
https://www.readbyqxmd.com/read/25667568/cdna-synthesis-for-bcr-abl1-detection-at-the-mmr-level-the-importance-of-using-the-appropriate-kit
#19
Jianxiang Chi, Chryso Pierides, Andrie Mitsidou, Andri Miltiadou, Petroula Gerasimou, Paul Costeas
BACKGROUND: The synthesis of complementary DNA (cDNA) for use in the detection of BCR-ABL1 at the Major Molecular Response (MMR) level is a well-established method used by clinical laboratories world-wide. However, the quality of cDNA provides sensitivity challenges and consequently affects the detection of Minimal Residual Disease (MRD). RESULTS: Herein, we evaluated six commercially available kits for the synthesis of cDNA according to amplification success rate, linearity and ABL1 copy number...
2015: Biological Procedures Online
https://www.readbyqxmd.com/read/25564351/lna-units-present-in-the-2-ome-rna-strand-stabilize-parallel-duplexes-2-ome-rna-all-r-p-ps-dna-and-parallel-triplexes-2-ome-rna-all-r-p-ps-dna-rna-an-improved-tool-for-the-inhibition-of-reverse-transcription
#20
Anna Maciaszek, Agnieszka Krakowiak, Magdalena Janicka, Agnieszka Tomaszewska-Antczak, Milena Sobczak, Barbara Mikołajczyk, Piotr Guga
Homopurine phosphorothioate analogs of DNA, possessing all phosphorus atoms of RP configuration ([All-RP-PS]-DNA), when interact with appropriate complementary RNA or (2'-OMe)-RNA templates, form parallel triplexes or parallel duplexes of very high thermodynamic stability. The present results show that T-LNA or 5-Me-C-LNA units introduced into the parallel Hoogsteen-paired (2'-OMe)-RNA strands (up to four units in the oligomers of 9 or 12 nt in length) stabilize these parallel complexes. At neutral pH, dodecameric parallel duplexes have Tm values of 62-68 °C, which are by 4-10 °C higher than Tm for the reference duplex (with no LNA units present), while for the corresponding triplexes, Tm values exceeded 85 °C...
February 28, 2015: Organic & Biomolecular Chemistry
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