keyword
MENU ▼
Read by QxMD icon Read
search

defense pathways

keyword
https://www.readbyqxmd.com/read/29653456/hesperidin-prevents-high-glucose-induced-damage-of-retinal-pigment-epithelial-cells
#1
Wayne Young Liu, Shorong-Shii Liou, Tang-Yao Hong, I-Min Liu
The present study aimed to determine whether hesperidin, a plant-based active flavanone found in citrus fruits, can prevent high glucose-induced retinal pigment epithelial (RPE) cell impairment. Cultured human RPE cells (ARPE-19) were exposed to a normal glucose concentration (5.5 mM) for 4 d and then soaked in either normal (5.5 mM) or high (33.3 mM) concentrations of D-glucose with or without different concentrations of hesperidin (10, 20, or 40 µM) for another 48 h. The survival rates of the cells were measured using a 3-(4,5-dimethyl thiazol-2-yl)-2,5-diphenyl tetrazolium bromide reduction assay...
April 13, 2018: Planta Medica
https://www.readbyqxmd.com/read/29652796/expressing-osmpk4-impairs-plant-growth-but-enhances-the-resistance-of-rice-to-the-striped-stem-borer-chilo-suppressalis
#2
Xiaoli Liu, Jiancai Li, Liping Xu, Qi Wang, Yonggen Lou
Mitogen-activated protein kinases (MPKs) play a central role not only in plant growth and development, but also in plant responses to abiotic and biotic stresses, including pathogens. Yet, their role in herbivore-induced plant defenses and their underlying mechanisms remain largely unknown. Here, we cloned a rice MPK gene, OsMPK4 , whose expression was induced by mechanical wounding, infestation of the striped stem borer (SSB) Chilo suppressalis , and treatment with jasmonic acid (JA), but not by treatment with salicylic acid (SA)...
April 13, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29651660/comparative-analysis-of-transcriptome-in-two-wheat-genotypes-with-contrasting-levels-of-drought-tolerance
#3
Jitendra Kumar, Samatha Gunapati, Shahryar F Kianian, Sudhir P Singh
Drought tolerance is a complex trait that is governed by multiple genes. The study presents differential transcriptome analysis between drought-tolerant (Triticum aestivum Cv. C306) and drought-sensitive (Triticum aestivum Cv. WL711) genotypes, using Affymetrix GeneChip® Wheat Genome Array. Both genotypes exhibited diverse global transcriptional responses under control and drought conditions. Pathway analysis suggested significant induction or repression of genes involved in secondary metabolism, nucleic acid synthesis, protein synthesis, and transport in C306, as compared to WL711...
April 12, 2018: Protoplasma
https://www.readbyqxmd.com/read/29649215/mobile-phone-specific-electromagnetic-fields-induce-transient-dna-damage-and-nucleotide-excision-repair-in-serum-deprived-human-glioblastoma-cells
#4
Halh Al-Serori, Franziska Ferk, Michael Kundi, Andrea Bileck, Christopher Gerner, Miroslav Mišík, Armen Nersesyan, Monika Waldherr, Manuel Murbach, Tamara T Lah, Christel Herold-Mende, Andrew R Collins, Siegfried Knasmüller
Some epidemiological studies indicate that the use of mobile phones causes cancer in humans (in particular glioblastomas). It is known that DNA damage plays a key role in malignant transformation; therefore, we investigated the impact of the UMTS signal which is widely used in mobile telecommunications, on DNA stability in ten different human cell lines (six brain derived cell lines, lymphocytes, fibroblasts, liver and buccal tissue derived cells) under conditions relevant for users (SAR 0.25 to 1.00 W/kg)...
2018: PloS One
https://www.readbyqxmd.com/read/29649063/ganoderma-lucidum-polysaccharide-peptide-attenuates-skin-flap-ischemia-reperfusion-injury-in-a-thioredoxin-dependent-manner
#5
Huiwen Ren, Xiangbo Meng, Jian Yin, Jingyan Sun, Qingfeng Huang, Zhuming Yin
BACKGROUND: Thioredoxin-1 (Trx-1) plays an important role in defensing the skin flap ischemia-reperfusion injury. Ganoderma lucidum polysaccharide peptide (GLPP) is the major component of Ganoderma lucidum, which possesses potent antioxidant and antiapoptotic activity. Our study aims to determine whether GLPP could attenuate the skin flap ischemia-reperfusion injury and investigate possible mechanisms involved. METHODS: The dermoprotective effect and mechanisms were assessed by an in vivo mouse ischemia-reperfusion flap model and an in vitro epithelial skin cell hypoxia/reoxygenation model...
March 29, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29648949/induced-systemic-resistance-against-citrus-canker-disease-by-rhizospheric-bacteria
#6
Nadia Riera, Han Wang, Yong Li, Jinyun Li, Kirsten Pelz-Stelinski, Nian Wang
Citrus canker, caused by Xanthomonas citri subsp. citri (Xcc), is an important citrus disease that causes significant economic losses worldwide. All commercial citrus varieties are susceptible to citrus canker. Currently, chemical control with copper based products is the main approach to control Xcc dispersal and plant colonization. However, extensive use of copper compounds can result in copper-resistant strains and cause adverse effects on the environment. Alternatives to chemical control involve the activation of citrus immunity to control the disease...
April 12, 2018: Phytopathology
https://www.readbyqxmd.com/read/29648614/overexpression-of-ospgip2-confers-sclerotinia-sclerotiorum-resistance-in-brassica-napus-through-increased-activation-of-defense-mechanisms
#7
Zhuanrong Wang, Lili Wan, Qiang Xin, Ye Chen, Xiaohui Zhang, Faming Dong, Dengfeng Hong, Guangsheng Yang
Sclerotinia stem rot (SSR), caused by Sclerotinia sclerotiorum, is the most serious disease affecting the yield of the agriculturally and economically important crop, Brassica napus L. (rapeseed). In this study, Oryza sativa polygalacturonase-inhibiting protein 2 (OsPGIP2) effectively enhanced rapeseed immunity against S. sclerotiorum infection. Leaf extracts of B. napus plants overexpressing OsPGIP2 showed enhanced S. sclerotiorum resistance by delaying pathogen infection. The constitutive expression of OsPGIP2 in rapeseed plants provided a rapid and potentiated defense response, including the production of reactive oxygen species, interaction with S...
April 10, 2018: Journal of Experimental Botany
https://www.readbyqxmd.com/read/29648516/the-phosphodiesterase-4-inhibitor-roflumilast-reverts-proteolysis-in-skeletal-muscle-cells-of-patients-with-copd-cachexia
#8
Esther Barreiro, Ester Puig-Vilanova, Anna Salazar-Degracia, Sergi Pascual-Guardia, Carme Casadevall, Joaquim Gea
Peripheral muscle weakness and mass loss are characteristic features in severe COPD. We hypothesized that the phosphodiesterase-4 inhibitor roflumilast-induced cAMP may ameliorate proteolysis and metabolism in skeletal muscles of COPD patients with severe muscle wasting. In myogenic precursor cells (isolated from muscle biopsies and cultured up to obtain differentiated myotubes) from 10 severe COPD patients and 10 healthy controls, which were treated with 1 microM roflumilast N-oxide (RNO) for three time-cohorts (1h, 6h, and 24h), genes of antioxidant defense and oxidative stress marker, myogenesis and muscle metabolism, proteolysis (tyrosine release assay) and ubiquitin-proteasome system markers, autophagy, and myosin isoforms were analyzed using RT-PCR and immunoblotting...
April 12, 2018: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29643863/mutation-in-rice-abscisic-acid2-results-in-cell-death-enhanced-disease-resistance-altered-seed-dormancy-and-development
#9
Yongxiang Liao, Que Bai, Peizhou Xu, Tingkai Wu, Daiming Guo, Yongbin Peng, Hongyu Zhang, Xiaoshu Deng, Xiaoqiong Chen, Ming Luo, Asif Ali, Wenming Wang, Xianjun Wu
Lesion mimic mutants display spontaneous cell death, and thus are valuable for understanding the molecular mechanism of cell death and disease resistance. Although a lot of such mutants have been characterized in rice, the relationship between lesion formation and abscisic acid (ABA) synthesis pathway is not reported. In the present study, we identified a rice mutant, lesion mimic mutant 9150 ( lmm9150 ), exhibiting spontaneous cell death, pre-harvest sprouting, enhanced growth, and resistance to rice bacterial and blast diseases...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29643242/rlrs-and-tlrs-signaling-pathways-cause-aberrant-production-of-inflammatory-cytokines-chemokines-in-an-sftsv-infection-mouse-model
#10
Shintaro Yamada, Masayuki Shimojima, Ryo Narita, Yuta Tsukamoto, Hiroki Kato, Masayuki Saijo, Takashi Fujita
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a tick-borne phlebovirus of the family Bunyaviridae , the SFTS virus (SFTSV). Wild type and type I interferon (IFN-I) receptor 1-deficient (IFNAR1-/- ) mice have been established as non-lethal and lethal models of SFTSV infection, respectively. However, the mechanisms of IFN-I production in vivo and the factors causing the lethal disease are not well understood. Using bone marrow chimeric mice, we found that IFN-I signaling in hematopoietic cells was essential for survival from lethal SFTSV infection...
April 11, 2018: Journal of Virology
https://www.readbyqxmd.com/read/29642651/the-multifunctional-role-of-chitosan-in-horticultural-crops-a-review
#11
REVIEW
Rahat Sharif, Muhammad Mujtaba, Mati Ur Rahman, Abdullah Shalmani, Husain Ahmad, Toheed Anwar, Deng Tianchan, Xiping Wang
Chitosan is a naturally occurring compound and is commercially produced from seafood shells. It has been utilized in the induction of the defense system in both pre and post-harvest fruits and vegetables against fungi, bacteria, viruses, and other abiotic stresses. In addition to that, chitosan effectively improves the physiological properties of plants and also enhances the shelf life of post-harvest produces. Moreover, chitosan treatment regulates several genes in plants, particularly the activation of plant defense signaling pathways...
April 10, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29628931/the-novel-secreted-meloidogyne-incognita-effector-miise6-targets-the-host-nucleus-and-facilitates-parasitism-in-arabidopsis
#12
Qianqian Shi, Zhenchuan Mao, Xiaoping Zhang, Jian Ling, Runmao Lin, Xi Zhang, Rui Liu, Yunsheng Wang, Yuhong Yang, Xinyue Cheng, Bingyan Xie
Meloidogyne incognita is highly specialized parasite that interacts with host plants using a range of strategies. The effectors are synthesized in the esophageal glands and secreted into plant cells through a needle-like stylet during parasitism. In this study, based on RNA-seq and bioinformatics analysis, we predicted 110 putative Meloidogyne incognita effectors that contain nuclear localization signals (NLSs). Combining the Burkholderia glumae -pEDV based screening system with subcellular localization, from 20 randomly selected NLS effector candidates, we identified an effector MiISE6 that can effectively suppress B...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29628888/licochalcone-a-upregulates-nrf2-antioxidant-pathway-and-thereby-alleviates-acetaminophen-induced-hepatotoxicity
#13
Hongming Lv, Qingfei Xiao, Junfeng Zhou, Haihua Feng, Guowen Liu, Xinxin Ci
Acetaminophen (APAP) overdose-induced fatal hepatotoxicity is majorly characterized by overwhelmingly increased oxidative stress while enhanced nuclear factor-erythroid 2-related factor 2 (Nrf2) is involved in prevention of hepatotoxicity. Although Licochalcone A (Lico A) upregulates Nrf2 signaling pathway against oxidative stress-triggered cell injury, whether it could protect from APAP-induced hepatotoxicity by directly inducing Nrf2 activation is still poorly elucidated. This study aims to explore the protective effect of Lico A against APAP-induced hepatotoxicity and its underlying molecular mechanisms...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29628876/korean-red-ginseng-pretreatment-protects-against-long-term-sensorimotor-deficits-after-ischemic-stroke-likely-through-nrf2
#14
Lei Liu, Mary K Vollmer, Victoria M Fernandez, Yasmin Dweik, Hocheol Kim, Sylvain Doré
Endogenous neuroprotective mechanisms by which the brain protects itself against noxious stimuli and recovers from ischemic damage are key targets of stroke research, ultimately facilitating functional recovery. Transcriptional factor Nrf2, enriched in astrocytes, is a master regulator of endogenous defense systems against oxidative stress and inflammation. Korean Red Ginseng (Ginseng), one most widely used herbal medicine, has exhibited promising potentials in neuroprotection. Our study aimed to determine whether the standardized Ginseng extract pretreatment could attenuate acute sensorimotor deficits and improve long-term functional recovery after ischemic stroke though Nrf2 pathway and whether reactive astrogliosis is associated with such effect...
2018: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29627672/cd-resistant-characterization-of-mutant-strain-irradiated-by-carbon-ion-beam
#15
Xin Li, Jie Wang, Zhouliang Tan, Liang Ma, Dong Lu, Wenjian Li, Jufang Wang
Heavy metal pollution is harmful to the environment and to human health. Resistant strains can grow in adverse conditions and store heavy metals to reduce their damage. The Cd2+ resistant mutant strain C2, which was irradiated by the12 C6+ beams, can grow in Cd medium ranging from 20 to 100 mg L-1 when compared with the original strain. Attempting to discern the cause of the resistance, the phenotype and antioxidant defense system were analyzed. SEM images showed that when exposed to Cd2+ , gaps on the cell surface were filled with a complex granular compound...
March 26, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29626540/supramolecular-assembly-of-human-pulmonary-surfactant-protein-sp-d
#16
R Arroyo, A Martin-González, M Echaide, A Jain, W H Brondyk, J Rosenbaum, F Moreno-Herrero, J Perez-Gil
Pulmonary surfactant protein D (SP-D) is a glycoprotein from the collectin family that is a component of the lung surfactant system. It exhibits host defense and immune regulatory functions in addition to contributing to the homeostasis of the surfactant pool within the alveolar airspaces. It is known that the SP-D monomer forms trimers, which further associate into higher order oligomers. However, the pathway and the interactions involved in the assembly of SP-D oligomers are not clearly understood. In the current study, a recombinant form of full-length human SP-D (rhSP-D) has been qualitatively and quantitatively studied by Atomic Force Microscopy (AFM) and electrophoresis, with the aim to understand the conformational diversity and the determinants defining the oligomerization of the protein...
April 4, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29626489/microrna-repertoire-and-comparative-analysis-of-andrias-davidianus-infected-with-ranavirus-using-deep-sequencing
#17
Yan Meng, Haifeng Tian, Qiaomu Hu, Hongwei Liang, Lingbing Zeng, Hanbing Xiao
Andrias davidianus is a large and economically important amphibian in China. Ranavirus infection causes serious losses in A. davidianus farming industry. MicroRNA mediated host-pathogen interactions are important in antiviral defense. In this study, five small-RNA libraries from ranavirus infected and non-infected A. davidianus spleens were sequenced using high throughput sequencing. The miRNA expression pattern, potential functions, and target genes were investigated. In total, 1356 known and 431 novel miRNAs were discovered...
April 4, 2018: Developmental and Comparative Immunology
https://www.readbyqxmd.com/read/29625033/galectins-control-mtor-in-response-to-endomembrane-damage
#18
Jingyue Jia, Yakubu Princely Abudu, Aurore Claude-Taupin, Yuexi Gu, Suresh Kumar, Seong Won Choi, Ryan Peters, Michal H Mudd, Lee Allers, Michelle Salemi, Brett Phinney, Terje Johansen, Vojo Deretic
The Ser/Thr protein kinase mTOR controls metabolic pathways, including the catabolic process of autophagy. Autophagy plays additional, catabolism-independent roles in homeostasis of cytoplasmic endomembranes and whole organelles. How signals from endomembrane damage are transmitted to mTOR to orchestrate autophagic responses is not known. Here we show that mTOR is inhibited by lysosomal damage. Lysosomal damage, recognized by galectins, leads to association of galectin-8 (Gal8) with the mTOR apparatus on the lysosome...
April 5, 2018: Molecular Cell
https://www.readbyqxmd.com/read/29622793/camp-independent-non-pigmentary-actions-of-variant-melanocortin-1-receptor-akt-mediated-activation-of-protective-responses-to-oxidative-dna-damage
#19
María Castejón-Griñán, Cecilia Herraiz, Conchi Olivares, Celia Jiménez-Cervantes, Jose Carlos García-Borrón
The melanocortin 1 receptor gene (MC1R), a well-established melanoma susceptibility gene, regulates the amount and type of melanin pigments formed within epidermal melanocytes. MC1R variants associated with increased melanoma risk promote the production of photosensitizing pheomelanins as opposed to photoprotective eumelanins. Wild-type (WT) MC1R activates DNA repair and antioxidant defenses in a cAMP-dependent fashion. Since melanoma-associated MC1R variants are hypomorphic in cAMP signaling, these non-pigmentary actions are thought to be defective in MC1R-variant human melanoma cells and epidermal melanocytes, consistent with a higher mutation load in MC1R-variant melanomas...
April 6, 2018: Oncogene
https://www.readbyqxmd.com/read/29622626/triggered-recruitment-of-escrt-machinery-promotes-endolysosomal-repair
#20
Michael L Skowyra, Paul H Schlesinger, Teresa V Naismith, Phyllis I Hanson
Endolysosomes can be damaged by diverse materials. Terminally damaged compartments are degraded by lysophagy, but pathways that repair salvageable organelles are poorly understood. Here we found that the endosomal sorting complex required for transport (ESCRT) machinery, known to mediate budding and fission on endolysosomes, also plays an essential role in their repair. ESCRTs were rapidly recruited to acutely injured endolysosomes through a pathway requiring calcium and ESCRT-activating factors that was independent of lysophagy...
April 6, 2018: Science
keyword
keyword
70969
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"