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https://www.readbyqxmd.com/read/29051820/vqmapkkk38-is-essential-for-stilbene-accumulation-in-grapevine
#1
Yuntong Jiao, Dan Wang, Lan Wang, Changyue Jiang, Yuejin Wang
Vitis species, including grapevine, produce a class of secondary metabolites called stilbenes that are important for plant disease resistance and can have positive effects on human health. Mitogen-activated protein kinase (MAPK) signaling cascades not only play key roles in plant defense responses but also contribute to stilbene biosynthesis in grapevine. MAPKKKs function at the upper level of the MAPK network and initiate signaling through this pathway. In this study, a Raf-like MAPKKK gene, VqMAPKKK38, was identified and functionally characterized from the Chinese wild grapevine V...
2017: Horticulture Research
https://www.readbyqxmd.com/read/29051662/improving-phenolic-bioactive-linked-anti-hyperglycemic-functions-of-dark-germinated-barley-sprouts-hordeum-vulgare-l-using-seed-elicitation-strategy
#2
Ramnarain Ramakrishna, Dipayan Sarkar, Avani Manduri, Shreyas Ganesan Iyer, Kalidas Shetty
Sprouts of cereal grains, such as barley (Hordeum vulgare L.), are a good source of beneficial phenolic bioactives. Such health relevant phenolic bioactives of cereal sprouts can be targeted to manage chronic hyperglycemia and oxidative stress commonly associated with type 2 diabetes (T2D). Therefore improving phenolic bioactives by stimulating plant endogenous defense responses such as protective pentose phosphate pathway (PPP) during sprouting has significant merit. Based on this metabolic rationale, this study aimed to enhance phenolic bioactives and associated antioxidant and anti-hyperglycemic functions in dark germinated barley sprouts using exogenous elicitor treatments...
October 2017: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29050987/gill-transcriptomes-reveal-involvement-of-cytoskeleton-remodeling-and-immune-defense-in-ammonia-stress-response-in-the-banana-shrimp-fenneropenaeus-merguiensis
#3
Wei Wang, Shiping Yang, Chenggui Wang, Lili Shi, Hui Guo, Siuming Chan
The banana shrimp, Fenneropenaeus merguiensis, is an important fishery species in the Indo-West Pacific region. As the shrimp is very sensitive to stressors such as ammonia stress in water, understanding the molecular mechanisms of stress tolerance in F. merguiensis is of pivotal importance for improving its farming performance. In the current study, by using the RNA sequencing platform and comparative transcriptomic analysis, we conducted a comprehensive study on the transcriptomic changes of F. merguiensis in response to ammonia stress...
October 16, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/29050337/comprehensive-immune-transcriptomic-analysis-in-bladder-cancer-reveals-subtype-specific-immune-gene-expression-patterns-of-prognostic-relevance
#4
Runhan Ren, Kathrin Tyryshkin, Charles H Graham, Madhuri Koti, D Robert Siemens
Recent efforts on genome wide profiling of muscle invasive bladder cancer (MIBC) have led to its classification into distinct genomic and transcriptomic molecular subtypes that exhibit variability in prognosis. Evolving evidence from recent immunotherapy trials has demonstrated the significance of pre-existing tumour immune profiles that could guide treatment decisions. To identify immune gene expression patterns associated with the molecular subtypes, we performed a comprehensive in silico immune transcriptomic profiling, utilizing transcriptomic data from 347 MIBC cases from The Cancer Genome Atlas (TCGA)...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29048113/salicylic-acid-dependent-immunity-contributes-to-resistance-against-rhizoctonia-solani-a-necrotrophic-fungal-agent-of-sheath-blight-in-rice-and-brachypodium-distachyon
#5
Yusuke Kouzai, Mamiko Kimura, Megumi Watanabe, Kazuki Kusunoki, Daiki Osaka, Tomoko Suzuki, Hidenori Matsui, Mikihiro Yamamoto, Yuki Ichinose, Kazuhiro Toyoda, Takakazu Matsuura, Izumi C Mori, Takashi Hirayama, Eiichi Miami, Yoko Nishizawa, Komaki Inoue, Yoshihiko Onda, Keiichi Mochida, Yoshiteru Noutoshi
Rhizoctonia solani is a soil-borne fungus causing sheath blight. In consistent with its necrotrophic life style, no rice cultivars fully resistant to R. solani are known, and agrochemical plant defense activators used for rice blast, which upregulate a phytohormonal salicylic acid (SA)-dependent pathway, are ineffective towards this pathogen. As a result of the unavailability of genetics, the infection process of R. solani remains unclear. We used the model monocotyledonous plants Brachypodium distachyon and rice, and evaluated the effects of phytohormone-induced resistance to R...
October 19, 2017: New Phytologist
https://www.readbyqxmd.com/read/29047092/redox-signaling-and-persistent-pulmonary-hypertension-of-the-newborn
#6
Megha Sharma, Adeleye J Afolayan
Reactive oxygen species (ROS) are redox-signaling molecules that are critically involved in regulating endothelial cell functions, host defense, aging, and cellular adaptation. Mitochondria are the major sources of ROS and important sources of redox signaling in pulmonary circulation. It is becoming increasingly evident that increased mitochondrial oxidative stress and aberrant signaling through redox-sensitive pathways play a direct causative role in the pathogenesis of many cardiopulmonary disorders including persistent pulmonary hypertension of the newborn (PPHN)...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046976/the-complement-system-and-preeclampsia
#7
REVIEW
Jean F Regal, Richard M Burwick, Sherry D Fleming
PURPOSE OF REVIEW: Preeclampsia affects 3-4% of pregnancies with few treatment options to reduce maternal and fetal harm. Recent evidence that targeting the complement system may be an effective therapeutic strategy in prevention or treatment of preeclampsia will be reviewed. RECENT FINDINGS: Studies in humans confirm the safety and efficacy of C5 blockade in complement-mediated disorders of pregnancy, including preeclampsia. Animal models mimic the placental abnormalities and/or the maternal symptoms which characterize preeclampsia...
October 18, 2017: Current Hypertension Reports
https://www.readbyqxmd.com/read/29046870/salmonella-populations-inside-host-cells
#8
REVIEW
Sónia Castanheira, Francisco García-Del Portillo
Bacteria of the Salmonella genus cause diseases ranging from gastroenteritis to life-threatening typhoid fever and are among the most successful intracellular pathogens known. After the invasion of the eukaryotic cell, Salmonella exhibits contrasting lifestyles with different replication rates and subcellular locations. Although Salmonella hyper-replicates in the cytosol of certain host cell types, most invading bacteria remain within vacuoles in which the pathogen proliferates at moderate rates or persists in a dormant-like state...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29046679/overexpression-of-npr1-in-brassica-juncea-confers-broad-spectrum-resistance-to-fungal-pathogens
#9
Sajad Ali, Zahoor A Mir, Anshika Tyagi, Hailay Mehari, Rajendra P Meena, Javaid A Bhat, Prashant Yadav, Pradeep Papalou, Sandhya Rawat, Anita Grover
Brassica juncea (Indian mustard) is a commercially important oil seed crop, which is highly affected by many biotic stresses. Among them, Alternaria leaf blight and powdery mildew are the most devastating diseases leading to huge yield losses in B. juncea around the world. In this regard, genetic engineering is a promising tool that may possibly allow us to enhance the B. juncea disease resistance against these pathogens. NPR1 (non-expressor of pathogen-related gene 1) is a bonafide receptor of salicylic acid (SA) which modulates multiple immune responses in plants especially activation of induced and systemic acquired resistance (SAR)...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29046440/innate-sensing-of-influenza-a-virus-hemagglutinin-glycoproteins-by-the-host-endoplasmic-reticulum-er-stress-pathway-triggers-a-potent-antiviral-response-via-er-associated-protein-degradation
#10
Dylan A Frabutt, Bin Wang, Sana Riaz, Richard C Schwartz, Yong-Hui Zheng
Innate immunity provides an immediate defense against infection after host cells sense "danger" signals from microbes. Endoplasmic reticulum (ER) stress arises from accumulation of misfolded/unfolded proteins when protein load overwhelms the ER folding capacity, which activates the unfolded protein response (UPR) to restore the ER homeostasis. Here, we show that a mechanism for antiviral innate immunity is triggered after the ER stress pathway senses viral glycoproteins. When hemagglutinin (HA) glycoproteins from influenza A virus (IAV) are expressed in cells, ER stress is induced, resulting in rapid HA degradation via proteasomes...
October 18, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29046251/mycobacterium-tuberculosis-esat6-induces-ifn-%C3%AE-gene-expression-in-macrophages-via-tlrs-mediated-signaling
#11
Ah-Ra Jang, Joo-Hee Choi, Sung Jae Shin, Jong-Hwan Park
Mycobacterium tuberculosis is a highly virulent bacterium that causes tuberculosis. It infects about one third of the world's population. Type I interferons (IFNs) play a detrimental role in host defense against M. tuberculosis infection. Proteins secreted by M. tuberculosis through ESX-1 secretion system contribute to type I IFNs production. However, the precise mechanism by which 6-kDa early secretory antigen target (ESAT6), one of ESX-1-mediated secretory proteins, induces type I IFNs production in host cells is currently unclear...
October 15, 2017: Cytokine
https://www.readbyqxmd.com/read/29045565/cigarette-sidestream-smoke-delays-nucleotide-excision-repair-inhibited-accumulation-of-repair-proteins-at-dna-lesions
#12
Guang Yang, Yuko Ibuki
Cigarette sidestream smoke (CSS) contains many carcinogens that induce DNA damage. DNA damage plays an important role in the initiation of cancer and several diseases, and repair is the major defense mechanism; however, the relationship between CSS and the repair of DNA damage remains unclear. We herein investigated whether CSS influences nucleotide excision repair (NER) in vivo and in vitro. HR-1 hairless mouse skin treated with CSS was exposed to UVB, as a result of which pyrimidine dimers (cyclobutane pyrimidine dimers (CPDs) and pyrimidine(6-4)pyrimidone photoproducts (6-4PPs)) were formed and repaired via the NER pathway...
October 13, 2017: Carcinogenesis
https://www.readbyqxmd.com/read/29044225/microrna-181b-is-increased-in-cystic-fibrosis-cells-and-impairs-lipoxin-a4-receptor-dependent-mechanisms-of-inflammation-resolution-and-antimicrobial-defense
#13
Anna Maria Pierdomenico, Sara Patruno, Marilina Codagnone, Felice Simiele, Veronica Cecilia Mari, Roberto Plebani, Antonio Recchiuti, Mario Romano
The involvement of microRNA (miR) in cystic fibrosis (CF) pathobiology is rapidly emerging. We previously documented that miR-181b controls the expression of the ALX/FPR2 receptor, which is recognized by the endogenous proresolution ligand, lipoxin (LX)A4. Here, we examined whether the miR-181b-ALX/FPR2 circuit was altered in CF. We examined human airways epithelial cells, normal (16HBE14o-), carrying the ΔF508 mutation (CFBE41o-) or corrected for this mutation (CFBE41o-/CEP-CFTR wt 6.2 kb), as well as monocyte-derived macrophages (MΦs) from CF patients...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29044181/a-novel-%C3%AE-adaptin-c-myc-complex-formation-modulated-by-oxidative-stress-in-the-control-of-the-cell-cycle-in-macrophages-and-its-implication-in-atherogenesis
#14
Victor García-González, Jaime Mas-Oliva
Our study tested the proposal that c-Myc activation in macrophages is differentially carried out dependent on the intracellular oxidative state of cells and potentially associated to the process of atherogenesis. Under our experimental conditions, the generation of reactive oxygen species carried out by the presence of oxidized low density lipoproteins (oxLDL) or Gram negative bacterial lipopolysaccharides (LPS) modifies the expression of cellular adhesion molecules such as c-Abl, calcium transport proteins such as the plasma membrane Ca(2+)-ATPase (PMCA), CD47, procaspase-7, CASP7, CHOP, transcriptional activators such as c-Jun and c-Myc and molecules that participate in the process of endocytosis like α- and β-adaptin...
October 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042627/tipe2-negatively-regulates-mycoplasma-pneumonia-triggered-immune-response-via-mapk-signaling-pathway
#15
Yuanyuan Zhang, Shufen Mei, Yunlian Zhou, Dehua Yang, Ting Pan, Zhimin Chen, Qingqing Wang
Excessive immune responses played an important role in pathophysiology of mycoplasma pneumonia (MP) infection. Tumor necrosis factor-α-induced protein 8-like 2 (TIPE2) is a negative regulator of immune response. This study investigated the expression change of TIPE2 and its role in immune defense against MP infection, as well as the underlying mechanisms. Expressions of TIPE2 both in patients and in macrophages in vitro after MP infection were measured. We further studied cytokine production and mitogen-activated protein kinase (MAPK) signaling function in macrophages with interfered expression of TIPE2 upon MP infection...
October 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29042403/plastic-transcriptomes-stabilize-immunity-to-pathogen-diversity-the-jasmonic-acid-and-salicylic-acid-networks-within-the-arabidopsis-botrytis-pathosystem
#16
Wei Zhang, Jason A Corwin, Daniel Copeland, Julie Feusier, Robert Eshbaugh, Fang Chen, Susanna Atwell, Daniel J Kliebenstein
To respond to pathogen attack, selection and associated evolution has led to the creation of plant immune system that are a highly effective and inducible defense system. Central to this system are the plant defense hormones jasmonic acid (JA) and salicylic acid (SA) and crosstalk between the two, which may play an important role in defense responses to specific pathogens or even genotypes. Here, we used the Arabidopsis-B. cinerea pathosystem to test how the host's defense system functions against genetic variation in a pathogen...
October 17, 2017: Plant Cell
https://www.readbyqxmd.com/read/29042289/current-evidence-on-the-effect-of-dietary-polyphenols-intake-on-chronic-diseases
#17
REVIEW
Chiara Costa, Aristidis Tsatsakis, Charalampos Mamoulakis, Michele Teodoro, Giusi Briguglio, Emanuela Caruso, Dimitris Tsoukalas, Denisa Margina, Efthimios Dardiotis, Demetrios Kouretas, Concettina Fenga
Polyphenols are secondary metabolites of plants. They comprise several antioxidant compounds and they are generally considered to be involved in the defense against human chronic diseases. During the last years, there has been growing scientific interest in their potential health benefits. In this comprehensive review, we focus on the current evidence defining the position of their dietary intake in the prevention/treatment of human chronic diseases, including prostate cancer and other types of cancer, cardiovascular diseases, diabetes mellitus and neurodegenerative diseases such as Alzheimer's and Parkinson's disease; we also discuss their ability to modulate multiple signalling transduction pathways involved in the pathophysiology of these diseases...
October 14, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29042027/too-much-of-a-good-thing-how-modulating-ltb4-actions-restore-host-defense-in-homeostasis-or-disease
#18
REVIEW
Stephanie L Brandt, C Henrique Serezani
The ability to regulate inflammatory pathways and host defense mechanisms is critical for maintaining homeostasis and responding to infections and tissue injury. While unbalanced inflammation is detrimental to the host; inadequate inflammation might not provide effective signals required to eliminate pathogens. On the other hand, aberrant inflammation could result in organ damage and impair host defense. The lipid mediator leukotriene B4 (LTB4) is a potent neutrophil chemoattractant and recently, its role as a dominant molecule that amplifies many arms of phagocyte antimicrobial effector function has been unveiled...
October 2017: Seminars in Immunology
https://www.readbyqxmd.com/read/29040362/prediction-of-protein-protein-interactions-between-fungus-magnaporthe-grisea-and-rice-oryza-sativa-l
#19
Shiwei Ma, Qi Song, Huan Tao, Andrew Harrison, Shaobo Wang, Wei Liu, Shoukai Lin, Ziding Zhang, Yufang Ai, Huaqin He
Rice blast disease caused by the fungus Magnaporthe grisea (M. grisea) is one of the most serious diseases for the cultivated rice Oryza sativa (O. sativa). A key factor causing rice blast disease and defense might be protein-protein interactions (PPIs) between rice and fungus. In this research, we have developed a computational pipeline to predict PPIs between blast fungus and rice. After cross-prediction by interolog-based and domain-based method, we achieved 532 potential PPIs between 27 fungus proteins and 236 rice proteins...
October 11, 2017: Briefings in Bioinformatics
https://www.readbyqxmd.com/read/29039783/quantitative-phosphoproteomic-analysis-provides-insight-into-the-response-to-short-term-drought-stress-in-ammopiptanthus-mongolicus-roots
#20
Huigai Sun, Bolin Xia, Xue Wang, Fei Gao, Yijun Zhou
Drought is one of the major abiotic stresses that negatively affects plant growth and development. Ammopiptanthus mongolicus is an ecologically important shrub in the mid-Asia desert region and used as a model for abiotic tolerance research in trees. Protein phosphorylation participates in the regulation of various biological processes, however, phosphorylation events associated with drought stress signaling and response in plants is still limited. Here, we conducted a quantitative phosphoproteomic analysis of the response of A...
October 17, 2017: International Journal of Molecular Sciences
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