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https://www.readbyqxmd.com/read/28291378/magnetic-resonance-spectroscopic-analysis-of-multifidus-muscles-lipid-content-and-association-with-spino-pelvic-malalignment-in-chronic-low-back-pain
#1
Izaya Ogon, Tsuneo Takebayashi, Hiroyuki Takashima, Tomonori Morita, Mitsunori Yoshimoto, Yoshinori Terashima, Toshihiko Yamashita
OBJECTIVE: To analyze intramyocellular lipids (IMCLs) and extramyocellular lipids (EMCLs) of the multifidus muscle (Mm) using MR spectroscopy (MRS) in chronic low back pain (CLBP) and control groups and to identify correlations with spino-pelvic alignment. METHODS: Forty (16 males, 24 females; mean age, 62.9 ± 1.9 years) patients whose visual analog scale scores were >30 mm for CLBP were included. Further, 40 control participants matched with the CLBP group subjects by sample size, gender and age (17 males, 23 females; mean age, 65...
March 14, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28277866/treatment-for-chronic-low-back-pain-the-focus-should-change-to-multimodal-management-that-reflects-the-underlying-pain-mechanisms
#2
Gerhard Müller-Schwefe, Bart Morlion, Karsten Ahlbeck, Eli Alon, Stefano Coaccioli, Flaminia Coluzzi, Frank Huygen, Wolfgang Jaksch, Eija Kalso, Magdalena Kocot-Kępska, Hans-Georg Kress, Ana Cristina Mangas, Cesar Margarit Ferri, Philippe Mavrocordatos, Andrew Nicolaou, Concepción Pérez Hernández, Joseph Pergolizzi, Michael Schaefer, Patrick Sichère
Chronic pain is the most common cause for people to utilize healthcare resources and has a considerable impact upon patients' lives. The most prevalent chronic pain condition is chronic low back pain (CLBP). CLBP may be nociceptive or neuropathic, or may incorporate both components. The presence of a neuropathic component is associated with more intense pain of longer duration, and a higher prevalence of co-morbidities. However, many physicians' knowledge of chronic pain mechanisms is currently limited and there are no universally accepted treatment guidelines, so the condition is not particularly well managed...
February 22, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28248895/the-quebec-serve-protect-low-back-pain-study-a-web-based-cross-sectional-investigation-of-prevalence-and-functional-impact-among-police-officers
#3
Nabiha Benyamina Douma, Charles Côté, Anaïs Lacasse
STUDY DESIGN: . Web-based cross-sectional study. OBJECTIVE: Describe the prevalence and the burden of low back pain (LBP) and chronic low back pain (CLBP) amongQuebec police officers. SUMMARY OF BACKGROUND DATA: Police officers have work-related factors associated with LBP, but chronicity and impacts of this condition have been little exploredamong this population. METHODS: Between May and October 2014, a web-based cross-sectional study was conducted among police officers working in the province of Quebec (Canada)...
February 28, 2017: Spine
https://www.readbyqxmd.com/read/28242487/the-likelihood-of-reaching-substantial-clinical-benefit-following-an-interlaminar-dynamic-spacer-for-chronic-low-back-pain-a-clinical-and-radiological-analysis-of-a-prospective-cohort
#4
Junseok Bae, Shih Min Lee, Sang-Ho Lee, Sang-Ha Shin, Ho-Jin Kim, Kyung-Hwan Kim
PURPOSE: Chronic low back pain (CLBP) often causes disabling pain that impairs a patient's quality of life. Surgical treatment is recommended for patients who do not respond to conservative treatments lasting more than six months. The purpose of this study is to present results after the use of an interlaminar dynamic spacer for CLBP. MATERIALS AND METHODS: We enrolled consecutive patients with CLBP irresponsive to more than six months of conservative treatment into the present study...
February 24, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28240912/domain-targeted-metabolomics-delineates-the-heterocycle-assembly-steps-of-colibactin-biosynthesis
#5
Eric P Trautman, Alan R Healy, Emilee E Shine, Seth B Herzon, Jason M Crawford
Modular polyketide synthases (PKSs) and nonribosomal peptide synthetases (NRPSs) comprise giant multidomain enzymes responsible for the "assembly line" biosynthesis of many genetically encoded small molecules. Site-directed mutagenesis, protein biochemical, and structural studies have focused on elucidating the catalytic mechanisms of individual multidomain proteins and protein domains within these megasynthases. However, probing their functions at the cellular level typically has invoked the complete deletion (or overexpression) of multidomain-encoding genes or combinations of genes and comparing those mutants with a control pathway...
March 10, 2017: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/28207662/expression-of-mirna-124a-in-cd4-cells-reflects-response-to-a-multidisciplinary-treatment-program-in-patients-with-chronic-low-back-pain
#6
Benjamin Luchting, Jens Heyn, Ludwig Christian Hinske, Shahnaz Christina Azad
STUDY DESIGN: A prospective evaluation of microRNA (miRNA) expression in patients with chronic low back pain (CLBP). OBJECTIVE: The aim of this study was to evaluate whether pain- and T cell-related miRNAs are differentially expressed in CLBP when compared with healthy volunteers and whether these miRNAs may distinguish between responders and nonresponders to a multidisciplinary treatment program. SUMMARY OF BACKGROUND DATA: CLBP is a common health problem worldwide...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28186946/gabapentinoids-for-chronic-low-back-pain-a-protocol-for-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#7
Harsha Shanthanna, Ian Gilron, Lehana Thabane, Philip J Devereaux, Mohit Bhandari, Rizq AlAmri, Manikandan Rajarathinam, Sriganesh Kamath
INTRODUCTION: Chronic low back pain (CLBP) is a common condition and causes significant pain, distress and disability across the world. It is multifactorial in aetiology and is challenging to manage. Although the underlying mechanism of pain is predominantly non-specific, many argue that there is a substantial neuropathic pain element. Neuropathic pain is more severe, with significant disability. Gabapentinoids, including gabapentin and pregabalin, have proven efficacy in some neuropathic pain conditions...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28167168/effects-of-a-16-week-pilates-exercises-training-program-for-isometric-trunk-extension-and-flexion-strength
#8
Irina Kliziene, Saule Sipaviciene, Jovita Vilkiene, Audrone Astrauskiene, Gintautas Cibulskas, Sarunas Klizas, Ginas Cizauskas
OBJECTIVE: To evaluate the effects of Pilates exercises designed to improve isometric trunk extension and flexion strength of muscles in women with chronic low back pain (cLBP). PARTICIPANTS: Female volunteers with cLBP were divided into an experimental group (EG; n = 27) and a control group (CG; n = 27). INTERVENTION: Pilates exercises were performed twice per week by the EG; the duration of each session was 60 min. The program lasted for 16 weeks; thus patients underwent a total of 32 exercise sessions...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28160750/repetitive-peripheral-magnetic-neurostimulation-of-multifidus-muscles-combined-with-motor-training-influences-spine-motor-control-and-chronic-low-back-pain
#9
Hugo Massé-Alarie, Louis-David Beaulieu, Richard Preuss, Cyril Schneider
OBJECTIVE: The study tested whether combining repetitive peripheral magnetic stimulation (RPMS) and motor training of the superficial multifidus muscle (MF) better improved the corticomotor control of spine than training alone in chronic low back pain (CLBP). METHODS: Twenty-one participants with CLBP were randomly allocated to [RPMS+training] and [Sham+training] groups for three sessions (S1-S3) over a week where MF was stimulated before training (volitional contraction)...
March 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28144457/alexander-technique-training-coupled-with-an-integrative-model-of-behavioral-prediction-in-teachers-with-low-back-pain
#10
Tahereh Kamalikhah, Mohammad Ali Morowatisharifabad, Farid Rezaei-Moghaddam, Mohammad Ghasemi, Mohammad Gholami-Fesharaki, Salma Goklani
BACKGROUND: Individuals suffering from chronic low back pain (CLBP) experience major physical, social, and occupational disruptions. Strong evidence confirms the effectiveness of Alexander technique (AT) training for CLBP. OBJECTIVES: The present study applied an integrative model (IM) of behavioral prediction for improvement of AT training. METHODS: This was a quasi-experimental study of female teachers with nonspecific LBP in southern Tehran in 2014...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28138782/clinical-classes-of-injured-workers-with-chronic-low-back-pain-a-latent-class-analysis-with-relationship-to-working-status
#11
Lisa C Carlesso, Y Raja Rampersaud, Aileen M Davis
PURPOSE: To determine (a) clinical classes of injured workers with chronic low back pain (CLBP), (b) predictors of class membership and (c) associations of classes with baseline work status. METHODS: Patients with CLBP from a tertiary care outpatient clinic in Toronto, Canada were sampled. Latent class analysis was applied to determine class structure using physical, psychological and coping indicators. Classes were interpreted by class-specific means and analyzed for predictors of membership...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28126358/self-reported-disability-according-to-the-international-classification-of-functioning-disability-and-health-low-back-pain-core-set-test-retest-agreement-and-reliability
#12
Karl S Bagraith, Jenny Strong, Pamela J Meredith, Steven M McPhail
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) Low Back Pain Core Set (LBP-CS) has been proposed as a tool to facilitate the description and measurement of chronic low back pain (CLBP) related disability. Patient ratings of ICF categories may serve as a practical and effective method for acquiring patient input on activity limitations and participation restrictions. OBJECTIVE: To investigate the test-retest agreement and reliability of patient ratings of activity and participation according to the LBP-CS...
January 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28119771/usefulness-of-four-commonly-used-neuropathic-pain-screening-questionnaires-in-patients-with-chronic-low-back-pain-a-cross-sectional-study
#13
Kapil Gudala, Babita Ghai, Dipika Bansal
BACKGROUND: Recently symptoms-based screening questionnaires have gained attention for screening for a neuropathic pain component (NePC) in various chronic pain conditions. The present study assessed the usefulness of four commonly used NePC screening questionnaires including the Self-completed douleur neuropathique 4 (S-DN4), the ID Pain, the painDETECT questionnaire (PDQ), and the Self-completed Leeds Assessment of neuropathic Symptoms and Signs (S-LANSS) questionnaire in patients with chronic low back pain (CLBP) to assess the presence of NePC...
January 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28119210/comparison-of-the-trunk-pelvis-and-lower-extremities-sagittal-plane-inter-segmental-coordination-and-variability-during-walking-in-persons-with-and-without-chronic-low-back-pain
#14
Samaneh Ebrahimi, Fahimeh Kamali, Mohsen Razeghi, Seyyed Arash Haghpanah
Inter-segmental coordination can be influenced by chronic low back pain (CLBP). The sagittal plane lower extremities inter-segmental coordination pattern and variability, in conjunction with the pelvis and trunk, were assessed in subjects with and without non-specific CLBP during free-speed walking. Kinematic data were collected from 10 non-specific CLBP and 10 non-CLBP control volunteers while the subjects were walking at their preferred speed. Sagittal plane time-normalized segmental angles and velocities were used to calculate continuous relative phase for each data point...
January 21, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28118259/comparisons-in-muscle-function-and-training-rehabilitation-outcomes-between-avoidance-endurance-model-subgroups
#15
Elisabeth Fehrmann, Kerstin Tuechler, Thomas Kienbacher, Patrick Mair, Juliane Spreitzer, Linda Fischer, Josef Kollmitzer, Gerold Ebenbichler
OBJECTIVES: Evidence suggests that chronic low back pain (cLBP) patients with fear-avoidance or endurance behavior are at risk of treatment failure and pain maintenance, with bodily over- or underuse being assumed as mediating mechanisms for pain chronification. This study sought to examine whether or not the avoidance-endurance model (AEM)-subgroups: fear-avoiders (FAR), distress-endurers (DER), eustress-endurers (EER), and adaptive responders (AR), differed in physical measures and outcomes after training therapy...
January 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28108318/response-inhibition-set-shifting-and-complex-executive-function-in-patients-with-chronic-lower-back-pain
#16
Rytis Masiliūnas, Dalia Vitkutė, Edgaras Stankevičius, Vaidas Matijošaitis, Kęstutis Petrikonis
OBJECTIVE: The aim of our study was to evaluate how response inhibition, set shifting, and complex executive function (represented by risky decision-making) are altered in chronic lower back pain patients. MATERIALS AND METHODS: A total of 29 patients with chronic lower back pain (CLBP >6 months) aged 49-69 years and 30 healthy volunteers matched for age, gender, and education were enrolled in a case-control study. The study was conducted in the Departments of Neurology and Neurosurgery of Panevėžys Regional Hospital, Lithuania...
January 2, 2017: Medicina
https://www.readbyqxmd.com/read/28073085/effect-of-investigator-observation-on-gait-parameters-in-individuals-with-and-without-chronic-low-back-pain
#17
Joshua Vickers, Austin Reed, Robert Decker, Bryan P Conrad, Marissa Olegario-Nebel, Heather K Vincent
Despite the ubiquity of gait assessment in clinic and research, it is unclear how observation impacts gait, particularly in persons with chronic pain and psychological stress. We compared temporal spatial gait patterns in people with and without chronic low back pain (CLBP) when they were aware and unaware of being observed. This was a repeated-measures, deception study in 55 healthy persons (32.0±12.4 yr, 24.2±2.7kg/m(2)) and persons with CLBP (51.9±17.9 yr, 27.8±4.4kg/m(2)). Participants performed one condition in which they were unaware of observation (UNW), and three conditions under investigator observation: (1) aware of observation (AWA), (2) investigators watching cadence, (3) investigators watching step length...
January 3, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28072801/vitamin-d-supplementation-in-patients-with-chronic-low-back-pain-an-open-label-single-arm-clinical-trial
#18
Babita Ghai, Dipika Bansal, Raju Kanukula, Kapil Gudala, Naresh Sachdeva, Saravdeep Singh Dhatt, Vishal Kumar
BACKGROUND: Vitamin-D deficiency may possibly be related to chronic low back pain (CLBP). OBJECTIVE: The study is aimed to assess the impact of vitamin-D supplementation on pain intensity, functional disability, and vitamin-D levels in patients with CLBP. STUDY DESIGN: Single arm open-label study. SETTING: Outpatient pain clinic of a tertiary care hospital. METHODS: Sixty-eight eligible patients (CLBP for = 3 months, pain score = 50 on visual analogue scale (VAS) and plasma 25-Hydroxyvitamin D3 levels < 30 ng/mL) were enrolled...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28052444/cortical-thickness-and-functional-connectivity-abnormality-in-chronic-headache-and-low-back-pain-patients
#19
Qing Yang, Zewei Wang, Lixia Yang, Yonghua Xu, Li Min Chen
This study aims to characterize the psychological wellbeing of chronic headache (CH) patients, to identify cortical structural abnormalities and any associations of those abnormalities with resting state functional connectivity (rsFC), and to determine whether such rsFC abnormality is specific to CH patients. Compared with healthy controls (CONCH ), CH patients suffered from mild depression, sleep disturbances, and relatively poor quality of life. CH patients also exhibited widespread cortical thickness (CT) abnormalities in left premotor (BA6), right primary somatosensory (S1) and right prefrontal (BA10) cortices, as well as in regions of default mode and executive control networks...
January 4, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28025357/deconstructing-chronic-low-back-pain-in-the-older-adult-step-by-step-evidence-and-expert-based-recommendations-for-evaluation-and-treatment-part-xii-leg-length-discrepancy
#20
Mark Havran, Joel D Scholten, Paula Breuer, Jennifer Lundberg, Gary Kochersberger, Dave Newman, Debra K Weiner
 To present the last in a 12-part series designed to deconstruct chronic low back pain (CLBP) in older adults. This article focuses on leg length discrepancy (LLD) and presents an algorithm outlining approaches to diagnosis and management of LLD in older adults, along with a representative clinical case. METHODS : Using a modified Delphi approach, the LLD evaluation and treatment algorithm was developed by a multidisciplinary expert panel representing expertise in physical therapy, geriatric medicine, and physical medicine and rehabilitation...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
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