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https://www.readbyqxmd.com/read/28526154/an-analysis-of-new-approaches-and-drug-formulations-for-treatment-of-chronic-low-back-pain
#1
REVIEW
Karishma Patel Bhangare, Alan D Kaye, Nebojsa Nick Knezevic, Kenneth D Candido, Richard D Urman
The prevalence of chronic low back pain (CLBP) is increasing. Treatment is effective in less than 50% of patients after 1 year. This review investigates new treatments for CLBP. An extensive literature review focuses on new treatments for CLBP. Their safety and efficacy were evaluated and are described in detail in this review. The investigation identified new treatments for CLBP including chemonucleolysis, platelet-rich plasma injections, artemin, tanezumab, and stem cells. Further research and innovation are needed to implement these methods into practice and assess clinical significance...
June 2017: Anesthesiology Clinics
https://www.readbyqxmd.com/read/28495243/validation-of-topographic-hybrid-spect-ct-scan-in-patients-with-and-without-non-specific-chronic-low-back-pain-a-prospective-comparative-study
#2
Erik Van de Kelft, Gino Verleye, An-Sofie Van de Kelft, Koen Melis, Johan Van Goethem
Background/context The evidence for the treatment for non-specific chronic low back pain (ns CLBP) is very weak. Besides the complexity of the pain experience, a good biological marker or tool enabling identification of a pain generator is lacking. Hybrid imaging, combining Single Photon Emission Computerized Tomography (SPECT) with Computerized Tomography (CT)-scan, has been proposed as useful in the diagnostic workup of CLBP patients. Purpose To evaluate the sensitivity of SPECT-CT in patients with ns CLBP (group I) as compared to patients without CLBP (Group II)...
May 8, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28481838/contribution-of-endocannabinoid-gene-expression-and-genotype-on-low-back-pain-susceptibility-and-chronicity
#3
Divya Ramesh, Amy D'Agata, Angela Starkweather, Erin Young
A major research emphasis has been focused on defining the molecular changes that occur from acute to chronic pain in order to identify potential therapeutic targets for chronic pain. As the endocannabinoid system is dynamically involved in pain signaling, a plausible mechanism that may contribute to chronic pain vulnerability involves alterations in the amount of circulating endocannabinoids. Therefore, this study sought to examine cannabinoid type-1 (CNR1), type-2 (CNR2) receptors, fatty acid amide hydrolase (FAAH) and the vanilloid receptor (TRPV1) gene expression profiles among individuals with acute and chronic LBP at their baseline visit...
May 5, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28463868/application-of-primary-care-guideline-for-chronic-low-back-pain-in-the-emergency-department
#4
Rebeca M Tacy, Sherry Donaworth, Kathleen Ballman
Chronic low back pain (CLBP) is a primary care condition that overflows into the emergency department (ED). No ED-specific practice guideline exists for the management of patients with CLBP in the ED setting. Back pain is a common chief complaint, with cases of CLBP making up to 50% of the patients seen with back pain in an urban, freestanding ED affiliated with a multicampus health system in the Midwest where 25% of patients live below the poverty line and 21.8% do not have primary care. Kolcaba's Theory of Comfort guides the implementation of an evidence-based practice application project...
April 2017: Advanced Emergency Nursing Journal
https://www.readbyqxmd.com/read/28461765/the-efficacy-of-a-preparatory-phase-of-a-touch-based-approach-in-treating-chronic-low-back-pain-a-randomized-controlled-trial
#5
Federico Zangrando, Giulia Piccinini, Clara Tagliolini, Gabriella Marsilli, Marco Iosa, Maria Chiara Vulpiani, Teresa Paolucci
BACKGROUND: Massage therapy is an important element of rehabilitation in the treatment of chronic low back pain (CLBP). The objective of this study was to determine the relative efficacy of massage therapy between traditional massage and a new massage approach for CLBP. We also examined whether any reduction in pain was linked to interoceptive awareness and parasympathetic activation. METHODS: A single-blind, randomized, controlled trial of 51 patients who were allocated into a traditional massage therapy group (TMG; N=24, mean age: 50...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28461229/electromyographic-and-kinematic-analysis-of-trunk-and-limb-muscles-during-a-holding-task-in-chronic-low-back-pain-individuals-and-healthy-controls
#6
Júlia Jubany, Michel Marina, Rosa Angulo-Barroso
BACKGROUND: Chronic low back pain (CLBP) affects a large proportion of the population and has been associated with different muscle dysfunctions. However, there is no consensus regarding muscle electromyography and kinematic patterns during fatiguing tasks. OBJECTIVE: To examine whether trunk and limb muscle fatigability and activation patterns of individuals suffering CLBP differ from those of healthy participants during a holding task. DESIGN: Cross-sectional study...
April 28, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28459826/validation-of-standard-operating-procedures-in-a-multicenter-retrospective-study-to-identify-omics-biomarkers-for-chronic-low-back-pain
#7
Concetta Dagostino, Manuela De Gregori, Christian Gieger, Judith Manz, Ivan Gudelj, Gordan Lauc, Laura Divizia, Wei Wang, Moira Sim, Iain K Pemberton, Jane MacDougall, Frances Williams, Jan Van Zundert, Dragan Primorac, Yurii Aulchenko, Leonardo Kapural, Massimo Allegri
Chronic low back pain (CLBP) is one of the most common medical conditions, ranking as the greatest contributor to global disability and accounting for huge societal costs based on the Global Burden of Disease 2010 study. Large genetic and -omics studies provide a promising avenue for the screening, development and validation of biomarkers useful for personalized diagnosis and treatment (precision medicine). Multicentre studies are needed for such an effort, and a standardized and homogeneous approach is vital for recruitment of large numbers of participants among different centres (clinical and laboratories) to obtain robust and reproducible results...
2017: PloS One
https://www.readbyqxmd.com/read/28458149/altered-spatiotemporal-characteristics-of-gait-in-older-adults-with-chronic-low-back-pain
#8
Gregory E Hicks, J Megan Sions, Peter C Coyle, Ryan T Pohlig
Previous studies in older adults have identified that chronic low back pain (CLBP) is associated with slower gait speed. Given that slower gait speed is a predictor of greater morbidity and mortality among older adults, it is important to understand the underlying spatiotemporal characteristics of gait among older adults with CLBP. The purposes of this study were to determine (1) if there are differences in spatiotemporal parameters of gait between older adults with and without CLBP during self-selected and fast walking and (2) whether any of these gait characteristics are correlated with performance of a challenging walking task, e...
April 23, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28456669/lumbar-muscle-structure-and-function-in-chronic-versus-recurrent-low-back-pain-a-cross-sectional-study
#9
Dorien Goubert, Robby De Pauw, Mira Meeus, Tine Willems, Barbara Cagnie, Stijn Schouppe, Jessica Van Oosterwijck, Evy Dhondt, Lieven Danneels
BACKGROUND CONTEXT: Heterogeneity exists within the low back pain population. Some patients recover after every pain episode, whereas others suffer daily from LBP complaints. Until now, studies rarely make a distinction between recurrent low back pain (RLBP) and chronic low back pain (CLBP), although both are characterized by a different clinical picture. Clinical experiences also indicate that heterogeneity exists within the CLBP population. Muscle degeneration, like atrophy, fat infiltration, alterations in muscle fiber type and altered muscle activity, compromises proper biomechanics and motion of the spinal units in low back pain (LBP) patients...
April 26, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28449303/brief-intervention-physical-exercise-and-cognitive-behavioural-group-therapy-for-patients-with-chronic-low-back-pain-the-cins-trial
#10
A Harris, T F Moe, H R Eriksen, T Tangen, S A Lie, T H Tveito, S E Reme
BACKGROUND AND OBJECTIVE: Cognitive-behavioural treatments (CBT) and physical group exercise (PE) have both shown promising effects in reducing disability and increasing work participation among chronic low back pain (CLBP) patients. A brief cognitive intervention (BI) has previously been demonstrated to reduce work disability in CLBP. The aim of this study was to test if the effect of BI could be further increased by adding either group CBT or group PE. METHODS: A total of 214 patients, all sick listed 2-10 months due to CLBP, were randomized to BI (n = 99), BI + group CBT (n = 55) or BI + group PE (n = 60)...
April 27, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28441294/effects-of-myofascial-release-in-nonspecific-chronic-low-back-pain-a-randomized-clinical-trial
#11
María D Arguisuelas, Juan Francisco Lisón, Daniel Sánchez-Zuriaga, Isabel Martínez-Hurtado, Julio Doménech-Fernández
STUDY DESIGN: Double-blind, randomized parallel sham-controlled trial with concealed allocation and intention-to treat analysis. OBJECTIVE: To investigate the effects of an isolate myofascial release (MFR) protocol on pain, disability, and fear-avoidance beliefs in patients with chronic low back pain (CLBP). SUMMARY OF BACKGROUND DATA: MFR is a form of manual medicine widely used by physiotherapists in the management of different musculoskeletal pathologies...
May 1, 2017: Spine
https://www.readbyqxmd.com/read/28440001/treating-low-back-pain-with-combined-cerebral-and-peripheral-electrical-stimulation-a-randomized-double-blind-factorial-clinical-trial
#12
F A Hazime, A F Baptista, D G de Freitas, R L Monteiro, R L Maretto, R H Hasue, S M A João
BACKGROUND: Recent evidence suggests that chronic low back pain is associated with plastic changes in the brain that can be modified by neuromodulation strategies. This study investigated the efficacy of transcranial direct current stimulation (tDCS) combined simultaneously with peripheral electrical stimulation (PES) for pain relief, disability and global perception in patients with chronic low back pain (CLBP). METHODS: Ninety-two patients with CLBP were randomized to receive 12 sessions on nonconsecutive days of anodal tDCS (primary motor cortex, M1), 100 Hz sensory PES (lumbar spine), tDCS + PES or sham tDCS + PES...
April 25, 2017: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/28422409/validation-of-the-japanese-version-of-the-fremantle-back-awareness-questionnaire-in-patients-with-low-back-pain
#13
Tomokiko Nishigami, Akira Mibu, Katsuyoshi Tanaka, Yuh Yamashita, Michele Eisemann Shimizu, Bennedict Wand, Mark J Catley, Tasha R Stanton, G Lorimer Moseley
BACKGROUND: There is a growing interest in the role of disturbed body perception in people with persistent pain problems such as chronic low back pain (CLBP). A questionnaire, the Fremantle Back Awareness Questionnaire (FreBAQ), was recently developed as a simple and quick way of assessing disturbed perceptual awareness of the back in people with CLBP and appears to have acceptable psychometric properties. The aim of the present study was to develop a Japanese version of the FreBAQ (FreBAQ-J) and evaluate its psychometric properties in a sample of Japanese people with low back pain (LBP)...
April 18, 2017: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/28420353/the-influence-of-fatigue-and-chronic-low-back-pain-on-muscle-recruitment-patterns-following-an-unexpected-external-perturbation
#14
Júlia Jubany, Lieven Danneels, Rosa Angulo-Barroso
BACKGROUND: Chronic low back pain (CLBP) has been associated with altered trunk muscle responses as well as increased muscle fatigability. CLBP patients and fatigued healthy subjects could experience similar neuromuscular strategies to attempt to protect the spine. The current study examined muscle activation differences between healthy and CLBP subjects following a perturbation. In addition, the possible role of muscle fatigue was evaluated by investigating the healthy control subjects in a non-fatigued and a fatigued condition...
April 19, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28413219/contemporary-biopsychosocial-exercise-prescription-for-chronic-low-back-pain-questioning-core-stability-programs-and-considering-context
#15
Peter Stilwell, Katherine Harman
This commentary explores the importance of considering the biopsychosocial model and contextual factors when prescribing exercise. Diverse exercise programs for patients with chronic low back pain (CLBP) produce similar outcomes, without one specific exercise protocol demonstrating clear superiority. One clear barrier to positive outcomes is poor exercise adherence. We suggest that there are certain common contextual factors present in all exercise prescription scenarios that may impact adherence and health-related outcomes...
March 2017: Journal of the Canadian Chiropractic Association
https://www.readbyqxmd.com/read/28395983/effects-of-holding-an-external-load-on-the-standing-balance-of-older-and-younger-adults-with-and-without-chronic-low-back-pain
#16
Leonardo Shigaki, Edgar Ramos Vieira, André Wilson de Oliveira Gil, Cynthia Gobbi Alves Araújo, Mariana Zingari Carmargo, Leandro Amaral Sturion, Marcio Roǵerio de Oliveira, Rubens A da Silva
OBJECTIVE: The purpose of this study was to assess the effect of holding an external load on the standing balance of younger and older adults with and without chronic low back pain (CLBP). METHODS: Twenty participants with and 20 without CLBP participated in the study. Each group contained 10 younger (50% men) and 10 older adults (50% men). Participants were instructed to look straight ahead while standing on a force platform during two 120-second trials with and without holding an external load (10% of body mass)...
April 8, 2017: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28382810/the-predictive-value-of-subsets-of-the-%C3%A3-rebro-musculoskeletal-pain-screening-questionnaire-for-return-to-work-in-chronic-low-back-pain
#17
Emmanuelle Opsommer, Gilles Rivier, Geert Crombez, Roger Hilfiker
BACKGROUND: Studies have shown that positive recovery expectations are associated with positive health outcomes in patients with chronic low back pain (CLBP) such as return to work (RTW) and the time to RTW. AIM: To compare the predictive value for RTW in CLBP using different subsets of the Örebro Musculoskeletal Pain Screening Questionnaire (ÖMPSQ). DESIGN: Longitudinal cohort study. SETTING: Rehabilitation center...
April 4, 2017: European Journal of Physical and Rehabilitation Medicine
https://www.readbyqxmd.com/read/28379056/a-randomized-trial-to-determine-the-duration-of-analgesia-following-a-15-and-a-30-minute-application-of-acupuncture-like-tens-on-patients-with-chronic-low-back-pain
#18
Yannick Tousignant-Laflamme, Claudia Laroche, Christine Beaulieu, Ann-Julie Bouchard, Sabrina Boucher, Mélanie Michaud-Létourneau
BACKGROUND: Acupuncture-like TENS (AL-TENS) has been shown to produce prolonged pain relief, but no study has yet investigated its duration on a population suffering from chronic low back pain (CLPB). OBJECTIVE: Our objective was to quantify the duration and magnitude of analgesia induced by a 15- or 30-minute application of AL-TENS. METHODOLOGY: We recruited a sample of 11 participants presenting with CLBP and conducted a randomized, crossover study, where participants were given AL-TENS for 15 and 30 minutes on two separate occasions...
April 5, 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28376851/chronic-low-back-pain-patients-use-of-level-of-knowledge-of-and-perceived-benefits-of-complementary-medicine-a-cross-sectional-study-at-an-academic-pain-center
#19
Julie Dubois, Emmanuelle Scala, Mohamed Faouzi, Isabelle Decosterd, Bernard Burnand, Pierre-Yves Rodondi
BACKGROUND: Chronic pain patients often use complementary medicine (CM) to alleviate their pain; however, little is known about the use of CM by chronic low back pain (cLBP) patients. We investigated the frequency of use of CM by cLBP patients, the perceived effects of these therapies, patients' knowledge regarding CM, and patient-physician communication regarding CM. METHOD: A cross-sectional survey was conducted from November 2014 to February 2015. A questionnaire was distributed by physicians to 238 consecutive patients consulting for cLBP at the Pain Center of Lausanne University Hospital, Switzerland...
April 4, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28365848/attenuation-of-cortical-activity-triggering-descending-pain-inhibition-in-chronic-low-back-pain-patients-a-functional-magnetic-resonance-imaging-study
#20
Yohei Matsuo, Jiro Kurata, Miho Sekiguchi, Katsuhiro Yoshida, Takuya Nikaido, Shin-Ichi Konno
PURPOSE: A considerable portion of chronic low back pain (cLBP) patients lack anatomical abnormality, resist conventional therapeutic interventions, and their symptoms are often complicated with psychological and social factors. Such patients have been reported to show cerebral abnormalities both in anatomy and function by neuroimaging studies. Here we examined differences in cerebral reactivity to a simulated low back pain stimulus between cLBP patients and healthy controls by functional magnetic resonance imaging (fMRI), and their behavioral correlates from a psychophysical questionnaire...
April 1, 2017: Journal of Anesthesia
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