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https://www.readbyqxmd.com/read/28207662/expression-of-mirna-124a-in-cd4-cells-reflects-response-to-a-multidisciplinary-treatment-program-in-patients-with-chronic-low-back-pain
#1
Benjamin Luchting, Jens Heyn, Ludwig Christian Hinske, Shahnaz Christina Azad
STUDY DESIGN: A prospective evaluation of microRNA (miRNA) expression in patients with chronic low back pain (CLBP). OBJECTIVE: The aim of this study was to evaluate whether pain- and T cell-related miRNAs are differentially expressed in CLBP when compared with healthy volunteers and whether these miRNAs may distinguish between responders and nonresponders to a multidisciplinary treatment program. SUMMARY OF BACKGROUND DATA: CLBP is a common health problem worldwide...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28186946/gabapentinoids-for-chronic-low-back-pain-a-protocol-for-systematic-review-and-meta-analysis-of-randomised-controlled-trials
#2
Harsha Shanthanna, Ian Gilron, Lehana Thabane, Philip J Devereaux, Mohit Bhandari, Rizq AlAmri, Manikandan Rajarathinam, Sriganesh Kamath
INTRODUCTION: Chronic low back pain (CLBP) is a common condition and causes significant pain, distress and disability across the world. It is multifactorial in aetiology and is challenging to manage. Although the underlying mechanism of pain is predominantly non-specific, many argue that there is a substantial neuropathic pain element. Neuropathic pain is more severe, with significant disability. Gabapentinoids, including gabapentin and pregabalin, have proven efficacy in some neuropathic pain conditions...
November 10, 2016: BMJ Open
https://www.readbyqxmd.com/read/28167168/effects-of-a-16-week-pilates-exercises-training-program-for-isometric-trunk-extension-and-flexion-strength
#3
Irina Kliziene, Saule Sipaviciene, Jovita Vilkiene, Audrone Astrauskiene, Gintautas Cibulskas, Sarunas Klizas, Ginas Cizauskas
OBJECTIVE: To evaluate the effects of Pilates exercises designed to improve isometric trunk extension and flexion strength of muscles in women with chronic low back pain (cLBP). PARTICIPANTS: Female volunteers with cLBP were divided into an experimental group (EG; n = 27) and a control group (CG; n = 27). INTERVENTION: Pilates exercises were performed twice per week by the EG; the duration of each session was 60 min. The program lasted for 16 weeks; thus patients underwent a total of 32 exercise sessions...
January 2017: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/28160750/repetitive-peripheral-magnetic-neurostimulation-of-multifidus-muscles-combined-with-motor-training-influences-spine-motor-control-and-chronic-low-back-pain
#4
Hugo Massé-Alarie, Louis-David Beaulieu, Richard Preuss, Cyril Schneider
OBJECTIVE: The study tested whether combining repetitive peripheral magnetic stimulation (RPMS) and motor training of the superficial multifidus muscle (MF) better improved the corticomotor control of spine than training alone in chronic low back pain (CLBP). METHODS: Twenty-one participants with CLBP were randomly allocated to [RPMS+training] and [Sham+training] groups for three sessions (S1-S3) over a week where MF was stimulated before training (volitional contraction)...
December 28, 2016: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28144457/alexander-technique-training-coupled-with-an-integrative-model-of-behavioral-prediction-in-teachers-with-low-back-pain
#5
Tahereh Kamalikhah, Mohammad Ali Morowatisharifabad, Farid Rezaei-Moghaddam, Mohammad Ghasemi, Mohammad Gholami-Fesharaki, Salma Goklani
BACKGROUND: Individuals suffering from chronic low back pain (CLBP) experience major physical, social, and occupational disruptions. Strong evidence confirms the effectiveness of Alexander technique (AT) training for CLBP. OBJECTIVES: The present study applied an integrative model (IM) of behavioral prediction for improvement of AT training. METHODS: This was a quasi-experimental study of female teachers with nonspecific LBP in southern Tehran in 2014...
September 2016: Iranian Red Crescent Medical Journal
https://www.readbyqxmd.com/read/28138782/clinical-classes-of-injured-workers-with-chronic-low-back-pain-a-latent-class-analysis-with-relationship-to-working-status
#6
Lisa C Carlesso, Y Raja Rampersaud, Aileen M Davis
PURPOSE: To determine (a) clinical classes of injured workers with chronic low back pain (CLBP), (b) predictors of class membership and (c) associations of classes with baseline work status. METHODS: Patients with CLBP from a tertiary care outpatient clinic in Toronto, Canada were sampled. Latent class analysis was applied to determine class structure using physical, psychological and coping indicators. Classes were interpreted by class-specific means and analyzed for predictors of membership...
January 31, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28126358/self-reported-disability-according-to-the-international-classification-of-functioning-disability-and-health-low-back-pain-core-set-test-retest-agreement-and-reliability
#7
Karl S Bagraith, Jenny Strong, Pamela J Meredith, Steven M McPhail
BACKGROUND: The International Classification of Functioning, Disability and Health (ICF) Low Back Pain Core Set (LBP-CS) has been proposed as a tool to facilitate the description and measurement of chronic low back pain (CLBP) related disability. Patient ratings of ICF categories may serve as a practical and effective method for acquiring patient input on activity limitations and participation restrictions. OBJECTIVE: To investigate the test-retest agreement and reliability of patient ratings of activity and participation according to the LBP-CS...
January 6, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28119771/usefulness-of-four-commonly-used-neuropathic-pain-screening-questionnaires-in-patients-with-chronic-low-back-pain-a-cross-sectional-study
#8
Kapil Gudala, Babita Ghai, Dipika Bansal
BACKGROUND: Recently symptoms-based screening questionnaires have gained attention for screening for a neuropathic pain component (NePC) in various chronic pain conditions. The present study assessed the usefulness of four commonly used NePC screening questionnaires including the Self-completed douleur neuropathique 4 (S-DN4), the ID Pain, the painDETECT questionnaire (PDQ), and the Self-completed Leeds Assessment of neuropathic Symptoms and Signs (S-LANSS) questionnaire in patients with chronic low back pain (CLBP) to assess the presence of NePC...
January 2017: Korean Journal of Pain
https://www.readbyqxmd.com/read/28119210/comparison-of-the-trunk-pelvis-and-lower-extremities-sagittal-plane-inter-segmental-coordination-and-variability-during-walking-in-persons-with-and-without-chronic-low-back-pain
#9
Samaneh Ebrahimi, Fahimeh Kamali, Mohsen Razeghi, Seyyed Arash Haghpanah
Inter-segmental coordination can be influenced by chronic low back pain (CLBP). The sagittal plane lower extremities inter-segmental coordination pattern and variability, in conjunction with the pelvis and trunk, were assessed in subjects with and without non-specific CLBP during free-speed walking. Kinematic data were collected from 10 non-specific CLBP and 10 non-CLBP control volunteers while the subjects were walking at their preferred speed. Sagittal plane time-normalized segmental angles and velocities were used to calculate continuous relative phase for each data point...
January 21, 2017: Human Movement Science
https://www.readbyqxmd.com/read/28118259/comparisons-in-muscle-function-and-training-rehabilitation-outcomes-between-avoidance-endurance-model-subgroups
#10
Elisabeth Fehrmann, Kerstin Tuechler, Thomas Kienbacher, Patrick Mair, Juliane Spreitzer, Linda Fischer, Josef Kollmitzer, Gerold Ebenbichler
OBJECTIVES: Evidence suggests that chronic low back pain (cLBP) patients with fear-avoidance or endurance behavior are at risk of treatment failure and pain maintenance, with bodily over- or underuse being assumed as mediating mechanisms for pain chronification. This study sought to examine whether or not the avoidance-endurance model (AEM)-subgroups: fear-avoiders (FAR), distress-endurers (DER), eustress-endurers (EER), and adaptive responders (AR), differed in physical measures and outcomes after training therapy...
January 21, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28108318/response-inhibition-set-shifting-and-complex-executive-function-in-patients-with-chronic-lower-back-pain
#11
Rytis Masiliūnas, Dalia Vitkutė, Edgaras Stankevičius, Vaidas Matijošaitis, Kęstutis Petrikonis
OBJECTIVE: The aim of our study was to evaluate how response inhibition, set shifting, and complex executive function (represented by risky decision-making) are altered in chronic lower back pain patients. MATERIALS AND METHODS: A total of 29 patients with chronic lower back pain (CLBP >6 months) aged 49-69 years and 30 healthy volunteers matched for age, gender, and education were enrolled in a case-control study. The study was conducted in the Departments of Neurology and Neurosurgery of Panevėžys Regional Hospital, Lithuania...
January 2, 2017: Medicina
https://www.readbyqxmd.com/read/28073085/effect-of-investigator-observation-on-gait-parameters-in-individuals-with-and-without-chronic-low-back-pain
#12
Joshua Vickers, Austin Reed, Robert Decker, Bryan P Conrad, Marissa Olegario-Nebel, Heather K Vincent
Despite the ubiquity of gait assessment in clinic and research, it is unclear how observation impacts gait, particularly in persons with chronic pain and psychological stress. We compared temporal spatial gait patterns in people with and without chronic low back pain (CLBP) when they were aware and unaware of being observed. This was a repeated-measures, deception study in 55 healthy persons (32.0±12.4 yr, 24.2±2.7kg/m(2)) and persons with CLBP (51.9±17.9 yr, 27.8±4.4kg/m(2)). Participants performed one condition in which they were unaware of observation (UNW), and three conditions under investigator observation: (1) aware of observation (AWA), (2) investigators watching cadence, (3) investigators watching step length...
January 3, 2017: Gait & Posture
https://www.readbyqxmd.com/read/28072801/vitamin-d-supplementation-in-patients-with-chronic-low-back-pain-an-open-label-single-arm-clinical-trial
#13
Babita Ghai, Dipika Bansal, Raju Kanukula, Kapil Gudala, Naresh Sachdeva, Saravdeep Singh Dhatt, Vishal Kumar
BACKGROUND: Vitamin-D deficiency may possibly be related to chronic low back pain (CLBP). OBJECTIVE: The study is aimed to assess the impact of vitamin-D supplementation on pain intensity, functional disability, and vitamin-D levels in patients with CLBP. STUDY DESIGN: Single arm open-label study. SETTING: Outpatient pain clinic of a tertiary care hospital. METHODS: Sixty-eight eligible patients (CLBP for = 3 months, pain score = 50 on visual analogue scale (VAS) and plasma 25-Hydroxyvitamin D3 levels < 30 ng/mL) were enrolled...
January 2017: Pain Physician
https://www.readbyqxmd.com/read/28052444/cortical-thickness-and-functional-connectivity-abnormality-in-chronic-headache-and-low-back-pain-patients
#14
Qing Yang, Zewei Wang, Lixia Yang, Yonghua Xu, Li Min Chen
This study aims to characterize the psychological wellbeing of chronic headache (CH) patients, to identify cortical structural abnormalities and any associations of those abnormalities with resting state functional connectivity (rsFC), and to determine whether such rsFC abnormality is specific to CH patients. Compared with healthy controls (CONCH ), CH patients suffered from mild depression, sleep disturbances, and relatively poor quality of life. CH patients also exhibited widespread cortical thickness (CT) abnormalities in left premotor (BA6), right primary somatosensory (S1) and right prefrontal (BA10) cortices, as well as in regions of default mode and executive control networks...
January 4, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28025357/deconstructing-chronic-low-back-pain-in-the-older-adult-step-by-step-evidence-and-expert-based-recommendations-for-evaluation-and-treatment-part-xii-leg-length-discrepancy
#15
Mark Havran, Joel D Scholten, Paula Breuer, Jennifer Lundberg, Gary Kochersberger, Dave Newman, Debra K Weiner
 To present the last in a 12-part series designed to deconstruct chronic low back pain (CLBP) in older adults. This article focuses on leg length discrepancy (LLD) and presents an algorithm outlining approaches to diagnosis and management of LLD in older adults, along with a representative clinical case. METHODS : Using a modified Delphi approach, the LLD evaluation and treatment algorithm was developed by a multidisciplinary expert panel representing expertise in physical therapy, geriatric medicine, and physical medicine and rehabilitation...
December 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28017604/effect-of-the-abdominal-hollowing-and-bracing-maneuvers-on-activity-pattern-of-the-lumbopelvic-muscles-during-prone-hip-extension-in-subjects-with-or-without-chronic-low-back-pain-a-preliminary-study
#16
Amir H Kahlaee, Leila Ghamkhar, Amir M Arab
OBJECTIVE: The purpose of this study was to compare the effect of abdominal hollowing (AH) and abdominal bracing (AB) maneuvers on the activity pattern of lumbopelvic muscles during prone hip extension (PHE) in participants with or without nonspecific chronic low back pain (CLBP). METHODS: Twenty women with or without CLBP participated in this cross-sectional observational study. The electromyographic activity (amplitude and onset time) of the contralateral erector spinae (CES), ipsilateral erector spinae (IES), gluteus maximus, and biceps femoris muscles was measured during PHE with and without abdominal maneuvers...
December 22, 2016: Journal of Manipulative and Physiological Therapeutics
https://www.readbyqxmd.com/read/28001268/the-evolving-role-of-physical-therapists-in-the-long-term-management-of-chronic-low-back-pain-longitudinal-care-using-assisted-self-management-strategies
#17
Paul F Beattie, Sheri P Silfies, Max Jordon
Background: Longitudinal studies have shown that the symptoms of chronic low back pain (CLBP) will follow an episodic trajectory characterized by periods of high and low pain intensity that can persist for many years. There is a growing belief that the contemporary approach of limiting physical therapy to short, but intense courses of treatment for (CLBP) may be sub-optimal because these limited "windows" of clinical care are not congruent with the natural history of this condition. Recent research has suggested that people with CLBP undergo substantial, and individualized long-term variations in the neural processing of nociception over time...
November 2016: Brazilian Journal of Physical Therapy
https://www.readbyqxmd.com/read/27939886/clbm-is-a-versatile-cation-promiscuous-mate-transporter-found-in-the-colibactin-biosynthetic-gene-cluster
#18
Jarrod J Mousa, Rachel C Newsome, Ye Yang, Christian Jobin, Steven D Bruner
Multidrug transporters play key roles in cellular drug resistance to toxic molecules, yet these transporters are also involved in natural product transport as part of biosynthetic clusters in bacteria and fungi. The genotoxic molecule colibactin is produced by strains of virulent and pathobiont Escherichia coli and Klebsiella pneumoniae. In the biosynthetic cluster is a multidrug and toxic compound extrusion protein (MATE) proposed to transport the prodrug molecule precolibactin across the cytoplasmic membrane, for subsequent cleavage by the peptidase ClbP and cellular export...
January 22, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27934011/a-mechanistic-model-for-colibactin-induced-genotoxicity
#19
Alan R Healy, Herman Nikolayevskiy, Jaymin R Patel, Jason M Crawford, Seth B Herzon
Precolibactins and colibactins represent a family of natural products that are encoded by the clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E. coli. clb(+) E. coli induce megalocytosis and DNA double-strand breaks in eukaryotic cells, but paradoxically, this gene cluster is found in the probiotic Nissle 1917. Evidence suggests precolibactins are converted to genotoxic colibactins by colibactin peptidase (ClbP)-mediated cleavage of an N-acyl-d-Asn side chain, and all isolation efforts have employed ΔclbP strains to facilitate accumulation of precolibactins...
December 7, 2016: Journal of the American Chemical Society
https://www.readbyqxmd.com/read/27920977/neurochemical-changes-in-patients-with-chronic-low-back-pain-detected-by-proton-magnetic-resonance-spectroscopy-a-systematic-review
#20
REVIEW
Xianjing Zhao, Maosheng Xu, Kristen Jorgenson, Jian Kong
BACKGROUND: Low back pain is a highly prevalent health problem around the world, affecting 50% to 85% of people at some point in life. The purpose of this systematic review is to summarize the previous proton magnetic resonance spectroscopy studies on brain chemical changes in patients with chronic low back pain (CLBP). METHODS: We identified relevant studies from a literature search of PubMed and EMBASE from 1980 to March 2016. Data extraction was performed on the subjects' characteristics, MRS methods, spectral analyses, cerebral metabolites and perceptual measurements...
2017: NeuroImage: Clinical
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