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https://www.readbyqxmd.com/read/28945000/rosmarinic-acid-down-regulates-no-and-pge2-expression-via-mapk-pathway-in-rat-chondrocytes
#1
We-Ping Chen, Guo-Jun Jin, Yan Xiong, Peng-Fei Hu, Jia-Peng Bao, Li-Dong Wu
Rosmarinic acid (RosA) is a water-soluble polyphenol, which can be isolated from many herbs such as orthosiphon diffuses and rosmarinus officinalis. Previous studies have shown that RosA possesses various biological properties. In this study, we investigate the anti-osteoarthritic effects of RosA in rat articular chondrocytes. Chondrocytes were pre-treated with RosA, followed by the stimulation of IL-1β. Real-time PCR and Western blot were performed to detect the expression of matrix metalloproteinase (MMP)-1, MMP-3 and MMP-13...
September 25, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28944864/halofuginone-attenuates-articular-cartilage-degeneration-by-inhibition-of-elevated-tgf%C3%A2-%C3%AE-1-signaling-in-articular-cartilage-in-a-rodent-osteoarthritis-model
#2
Wenbo Mu, Boyong Xu, Hairong Ma, Baochao Ji, Zhendong Zhang, Jiao Li, Abdusami Amat, Li Cao
Osteoarthritis (OA) is the most common degenerative condition of the weight‑bearing joints worldwide without effective medical therapy. In order to investigate whether administration of halofuginone (HF) may attenuate OA, the present study allocated 3‑month‑old male mice into Sham group, vehicle‑treated anterior cruciate ligament transection (ACLT) group and HF‑treated ACLT group. The present study determined that HF treatment reduced the expression of matrix metallopeptidase‑13 and collagen X in articular cartilage...
September 20, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28944439/hyperintense-signal-alteration-in-the-suprapatellar-fat-pad-on-mri-is-associated-with-degeneration-of-the-patellofemoral-joint-over-48%C3%A2-months-data-from-the-osteoarthritis-initiative
#3
Benedikt J Schwaiger, John Mbapte Wamba, Alexandra S Gersing, Michael C Nevitt, Luca Facchetti, Charles E McCulloch, Thomas M Link
OBJECTIVE: To analyze associations of suprapatellar fat pad (SPFP) hyperintense signal alterations and mass effect with progression of patellofemoral osteoarthritis (OA) and clinical symptoms over 48 months. MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative (n = 426; 51.8 ± 3.8 years; 49.8% women) without radiographic tibiofemoral OA underwent 3T-MRI of their right knees and clinical evaluation using the Knee Injury and Osteoarthritis Outcome Score at baseline and at 48 months...
September 24, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28943099/a-systematic-review-of-the-effects-of-platelet-rich-plasma-on-outcomes-for-patients-with-knee-osteoarthritis-and-following-total-knee-arthroplasty
#4
REVIEW
Tendai Aswad Muchedzi, Simon B Roberts
INTRODUCTION: Platelet rich plasma (PRP) has been suggested to be effective in the management of knee osteoarthritis. Review of current literature reveals conflicting evidence regarding the benefits of PRP in treating knee OA. Preclinical evidence supports the use of PRP injections to promote a favorable environment for joint tissue healing, targeting not only cartilage but also synovial and meniscal tissues which has a positive effect on delaying the progression of OA. Growth factors found in platelet granules are postulated to influence outcomes in knee OA and after total knee arthroplasty (TKA)...
September 21, 2017: Surgeon: Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland
https://www.readbyqxmd.com/read/28942549/the-effect-of-vitamin-d-status-on-pain-lower-limb-strength-and-knee-function-during-balance-recovery-in-people-with-knee-osteoarthritis-an-exploratory-study
#5
Pazit Levinger, Rezaul Begg, Kerrie M Sanders, Hanatsu Nagano, Calum Downie, Aaron Petersen, Alan Hayes, Flavia Cicuttini
The association between vitamin D and muscle function associated with balance recovery and falls in people with knee osteoarthritis is unclear. Those with vitamin D insufficiency demonstrated poorer knee function during balance recovery, greater pain and locomotor dysfunction. Vitamin D insufficiency may have an adverse effect on muscle power function. PURPOSE: Low vitamin D status in people with knee osteoarthritis (OA) is often reported to be associated with increased pain and locomotor dysfunction...
September 23, 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/28942368/dxa-derived-hip-shape-is-related-to-osteoarthritis-findings-from-in-the-mros-cohort
#6
Benjamin G Faber, Denis Baird, Celia L Gregson, Jenny S Gregory, Rebecca J Barr, Richard M Aspden, John Lynch, Michael C Nevitt, Nancy E Lane, Eric Orwoll, Jonathan H Tobias
OBJECTIVE: Statistical shape modeling (SSM) of radiographs has been used to explore relationships between altered joint shape and hip osteoarthritis (OA). We aimed to apply SSM to Dual-energy X-ray Absorptiometry (DXA) hip scans, and examine associations between resultant hip shape modes (HSMs), radiographic hip OA (RHOA), and hip pain, in a large population based cohort. METHOD: SSM was performed on baseline hip DXA scans from the Osteoporotic Fractures in Men (MrOS) Study...
September 20, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28942223/baicalin-suppresses-il-1%C3%AE-induced-expression-of-inflammatory-cytokines-via-blocking-nf-%C3%AE%C2%BAb-in-human-osteoarthritis-chondrocytes-and-shows-protective-effect-in-mice-osteoarthritis-models
#7
Chunhui Chen, Chuanxu Zhang, Leyi Cai, Huanguang Xie, Wei Hu, Te Wang, Di Lu, Hua Chen
Osteoarthritis (OA) is a degenerative joint disease with an inflammatory component that drives the degradation of cartilage extracellular matrix. Baicalin, a predominant flavonoid isolated from the dry root of Scutellaria baicalensis Georgi, has been reported to have anti-inflammatory effects. However, the anti-inflammatory effects of baicalin on OA have not been reported. Our study aimed to investigate the effect of baicalin on OA both in vitro and in vivo. In vitro, human OA chondrocytes were pretreated with baicalin (10, 50, 100μM) for 2h and subsequently stimulated with IL-1β for 24h...
September 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28941815/effect-of-protonation-on-the-mechanism-of-phosphate-monoester-hydrolysis-and-comparison-with-the-hydrolysis-of-nucleoside-triphosphate-in-biomolecular-motors
#8
Hammad Ali Hassan, Sadaf Rani, Tabeer Fatima, Farooq Ahmad Kiani, Stefan Fischer
Hydrolysis of phosphate groups is a crucial reaction in living cells. It involves the breaking of two strong bonds, i.e. the OaH bond of the attacking water molecule, and the POl bond of the substrate (Oa and Ol stand for attacking and leaving oxygen atoms). Mechanism of the hydrolysis reaction can proceed either by a concurrent or a sequential mechanism. In the concurrent mechanism, the breaking of OaH and POl bonds occurs simultaneously, whereas in the sequential mechanism, the OaH and POl bonds break at different stages of the reaction...
August 15, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28941045/transthyretin-deposition-promotes-progression-of-osteoarthritis
#9
Tokio Matsuzaki, Yukio Akasaki, Merissa Olmer, Oscar Alvarez-Garcia, Natalia Reixach, Joel N Buxbaum, Martin K Lotz
Deposition of amyloid is a common aging-associated phenomenon in several aging-related diseases. Osteoarthritis (OA) is the most prevalent joint disease, and aging is its major risk factor. Transthyretin (TTR) is an amyloidogenic protein that is deposited in aging and OA-affected human cartilage and promotes inflammatory and catabolic responses in cultured chondrocytes. Here, we investigated the role of TTR in vivo using transgenic mice overexpressing wild-type human TTR (hTTR-TG). Although TTR protein was detected in cartilage in hTTR-TG mice, the TTR transgene was highly overexpressed in liver, but not in chondrocytes...
September 22, 2017: Aging Cell
https://www.readbyqxmd.com/read/28940779/knee-alignment-is-quantitatively-related-to-periarticular-bone-morphometry-and-density-especially-in-those-with-osteoarthritis
#10
Grace H Lo, Mehveen Merchant, Jeffrey B Driban, Jeffrey Duryea, Lori Lyn Price, Charles B Eaton, Timothy E McAlindon
OBJECTIVE: Static alignment influences knee loading and predicts osteoarthritis (OA) progression. Periarticular bone is important in dispersing forces across the knee. And there is substantial evidence for molecular crosstalk between cartilage and subchondral bone. Our objective was to evaluate the relationship of periarticular trabecular morphology and bone mineral density (BMD) with knee alignment. METHODS: This was a cross-sectional analysis of Osteoarthritis Initiative (OAI) Bone Ancillary Study participants...
September 21, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28940111/hyperuricemia-is-associated-with-increased-apo-ai-fractional-catabolic-rates-and-dysfunctional-hdl-in-new-zealand-rabbits
#11
Miriam Martínez-Ramírez, Cristóbal Flores-Castillo, L Gabriela Sánchez-Lozada, Rocío Bautista-Pérez, Elizabeth Carreón-Torres, José Manuel Fragoso, José Manuel Rodriguez-Pérez, Fernando E García-Arroyo, Victoria López-Olmos, María Luna-Luna, Gilberto Vargas-Alarcón, Martha Franco, Oscar Pérez-Méndez
The potential cause-effect relationship between uric acid plasma concentrations and HDL functionality remains elusive. Therefore, this study aimed to explore the effect of oxonic acid (OA)-induced hyperuricemia on the HDL size distribution, lipid content of HDL subclasses, and apo AI turnover, as well as HDL functionality in New Zealand white rabbits. Experimental animals received OA 750 mg/kg/day by oral gavage during 21 days. The HDL-apo AI fractional catabolic rate (FCR) was determined by exogenous labeling with (125)I, and HDL subclasses were determined by sequential ultracentrifugation and PAGE...
September 22, 2017: Lipids
https://www.readbyqxmd.com/read/28940031/the-role-of-thermal-balneotherapy-in-the-treatment-of-obese-patient-with-knee-osteoarthritis
#12
Stefano Masiero, Filippo Vittadini, Costanza Ferroni, Anna Bosco, Roberto Serra, Anna Chiara Frigo, Antonio Frizziero
Osteoarthritis (OA) is the most common form of arthritis clinically characterized by joint pain, functional limitation, and reduced quality of life. Several studies have shown a clear link between obesity and higher risk of knee OA. According to the multifactorial OA pathogenesis, the management of this condition requires a multidisciplinary approach. The objective of this study is to evaluate hydrokinesitherapy effects in thermal setting in obese patients with knee OA. Fifty-three patients were assessed for eligibility, of which 33 refused the treatment, while 10 patients dropped out after the enrollment for personal reasons or inability to adhere to the program...
September 22, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28939526/inhibition-of-the-tgf-%C3%AE-1-smad-signaling-pathway-protects-against-cartilage-injury-and-osteoarthritis-in-a-rat-model
#13
Yong-Jian Wang, Min Shen, Shan Wang, Xin Wen, Xin-Rui Han, Zi-Feng Zhang, Hui Li, Fei Wang, Dong-Mei Wu, Jun Lu, Yuan-Lin Zheng
Transforming growth factor-β1 (TGF-β1) in osteoblastic cells triggers pathological changes observed in osteoarthritis (OA). Thus, we hypothesized that the inhibition of the TGF-β1/Smad signaling pathway could act to protect against cartilage injury in rats with OA. After establishment of rat models induced by papain and L-cysteine, rats were subsequently assigned into the TβRI inhibitors, normal control (NC) and OA model groups. RT-qPCR and western blotting were performed to determine mRNA and protein expressions of TGFβ1, Smad2, Smad3 and Activin receptor-like kinase 5 (ALK5), respectively...
September 19, 2017: Life Sciences
https://www.readbyqxmd.com/read/28939011/whole-genome-mrna-transcriptomics-analysis-reveals-different-modes-of-action-of-the-diarrheic-shellfish-poisons-okadaic-acid-and-dinophysis-toxin-1-versus-azaspiracid-1-in-caco-2-cells
#14
Marcia Bodero, Ron L A P Hoogenboom, Toine F H Bovee, Liza Portier, Laura de Haan, Ad Peijnenburg, Peter J M Hendriksen
A study with DNA microarrays was performed to investigate the effects of two diarrhetic and one azaspiracid shellfish poison, okadaic acid (OA), dinophysistoxin-1 (DTX-1) and azaspiracid-1 (AZA-1) respectively, on the whole-genome mRNA expression of undifferentiated intestinal Caco-2 cells. Previously, the most responding genes were used to develop a dedicated array tube test to screen shellfish samples on the presence of these toxins. In the present study the whole genome mRNA expression was analyzed in order to reveal modes of action and obtain hints on potential biomarkers suitable to be used in alternative bioassays...
September 19, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28937705/interventions-for-treating-genital-chlamydia-trachomatis-infection-in-pregnancy
#15
REVIEW
Catherine Cluver, Natalia Novikova, David Oa Eriksson, Kevin Bengtsson, Göran K Lingman
BACKGROUND: Genital Chlamydia trachomatis (C.trachomatis) infection may lead to pregnancy complications such as miscarriage, preterm labour, low birthweight, preterm rupture of membranes, increased perinatal mortality, postpartum endometritis, chlamydial conjunctivitis and C.trachomatis pneumonia.This review supersedes a previous review on this topic. OBJECTIVES: To establish the most efficacious and best-tolerated therapy for treatment of genital chlamydial infection in preventing maternal infection and adverse neonatal outcomes...
September 22, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28937277/injectable-viscoelastic-supplements-a-review-for-radiologists
#16
Dermot J Bowden, Caoimhe A Byrne, Abdullah Alkhayat, Stephen J Eustace, Eoin C Kavanagh
OBJECTIVE: Hyaluronic acid (HA) is increasingly used by musculoskeletal radiologists in the treatment of osteoarthritis (OA). Although the evidence base for its efficacy is controversial, it remains in common use. With initial evidence suggesting its efficacy in the knee, it is now offered for treating OA of the hip, ankle, and elsewhere. CONCLUSION: HA is available in a wide variety of preparations, which may vary in concentration and chemical composition. Clinicians offering intraarticular HA injection should be familiar with the common preparations available and the principal differences between them, its mechanism of action, and the profile of adverse effects associated with its use...
October 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28936682/early-versus-delayed-source-control-in-open-abdomen-management-for-severe-intra-abdominal-infections-a-retrospective-analysis-on-111-cases
#17
Stefano Rausei, Vincenzo Pappalardo, Laura Ruspi, Antonio Colella, Simone Giudici, Vincenzo Ardita, Francesco Frattini, Francesca Rovera, Luigi Boni, Gianlorenzo Dionigi
BACKGROUND: Time to source control plays a determinant prognostic role in patients having severe intra-abdominal infections (IAIs). Open abdomen (OA) management became an effective treatment option for peritonitis. Aim of this study was to analyze the correlation between time to source control and outcome in patients presenting with abdominal sepsis and treated by OA. METHODS: We retrospectively analyzed 111 patients affected by abdominal sepsis and treated with OA from May 2007 to May 2015...
September 21, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28935906/resilience-of-the-larval-slipper-limpet-crepidula-onyx-to-direct-and-indirect-diet-effects-of-ocean-acidification
#18
Elizaldy A Maboloc, Kit Yu Karen Chan
Ocean acidification (OA) is known to directly impact larval physiology and development of many marine organisms. OA also affects the nutritional quality and palatability of algae, which are principal food sources for many types of planktonic larvae. This potential indirect effect of OA via trophic interactions, however, has not been fully explored. In this study, veligers of Crepidula onyx were exposed to different pH levels representing the ambient (as control) and low pH values (pH 7.7 and pH 7.3) for 14 days, and were fed with Isochrysis galbana cultured at these three respective pHs...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28935810/sulfur-dioxide%C3%A2-suppresses-inflammatory-response-by-sulfenylating-nf-%C3%AE%C2%BAb-p65-at-cysteine-38-in-a-rat-model-of-acute-lung-injury
#19
Siyao Chen, Yaqian Huang, Zhiwei Liu, Wen Yu, Heng Zhang, Kun Li, Xiaoqi Yu, Chaoshu Tang, Bin Zhao, Junbao Du, Hongfang Jin
This study was designed to investigate whether endogenous sulfur dioxide (SO2) controlled pulmonary inflammation in a rat model of oleic acid (OA)-induced acute lung injury (ALI). In this model, adenovirus expressing aspartate aminotransferase (AAT) 1 was delivered to the lungs, and the levels of SO2 and pro-inflammatory cytokines in rat lung tissues were measured. In the human alveolar epithelial cell line A549, the nuclear translocation and DNA binding activities of wild-type (wt) and C38S NF-κB p65 were detected...
September 21, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28935435/subchondral-tibial-bone-texture-predicts-the-incidence-of-radiographic-knee-osteoarthritis-data-from-the-osteoarthritis-initiative
#20
T Janvier, R Jennane, H Toumi, E Lespessailles
OBJECTIVES: To evaluate whether trabecular bone texture (TBT) parameters measured on computed radiographs could predict the onset of radiographic knee osteoarthritis (OA). MATERIALS AND METHODS: Subjects from the Osteoarthritis Initiative with no sign of radiographic OA at baseline were included. Cases that developed either a global radiographic OA defined by the Kellgren-Lawrence (KL) scale, a joint space narrowing (JSN) or tibial osteophytes (TOS) were compared with the controls with no changes after 48 months of follow-up...
September 18, 2017: Osteoarthritis and Cartilage
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