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https://www.readbyqxmd.com/read/29339024/nrf2-are-pathway-attenuates-oxidative-and-apoptotic-response-in-human-osteoarthritis-chondrocytes-by-activating-erk1-2-elk1-p70s6k-p90rsk-signaling-axis
#1
Nazir M Khan, Imran Ahmad, Tariq M Haqqi
Nrf2, a redox regulated transcription factor, has recently been shown to play a role in cartilage integrity but the mechanism remains largely unknown. Osteoarthritis (OA) is a multifactorial disease in which focal degradation of cartilage occurs. Here, we studied whether Nrf2 exerts chondroprotective effects by suppressing the oxidative stress and apoptosis in IL-1β stimulated human OA chondrocytes. Expression of Nrf2 and its target genes HO-1, NQO1 and SOD2 was significantly high in OA cartilage compared to normal cartilage and was also higher in damaged area compared to smooth area of OA cartilage of the same patient...
January 12, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29337871/influence-of-kartogenin-on-chondrogenic-differentiation-of-human-bone-marrow-derived-mscs-in-2d-culture-and-in-co-cultivation-with-oa-osteochondral-explant
#2
Timea Spakova, Jana Plsikova, Denisa Harvanova, Marek Lacko, Stefan Stolfa, Jan Rosocha
Articular cartilage has limited capacity for natural regeneration and repair. In the present study, we evaluated kartogenin (KGN), a bioactive small heterocyclic molecule, for its effect on in vitro proliferation and chondrogenic differentiation of human bone marrow-derived mesenchymal stromal cells (hBMSCs) in monolayer culture and in co-culture models in vitro. OA osteochondral cylinders and hBMSCs were collected during total knee replacement. The effect of KGN on hBMSCs during 21 days of culture was monitored by real-time proliferation assay, immunofluorescence staining, histological assay, scanning electron microscopy (SEM) (imaging and multiplex enzyme-linked immunosorbent assay) ELISA assay...
January 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29336685/seroprevalence-of-q-fever-among-the-indigenous-people-orang-asli-of-peninsular-malaysia
#3
Chee-Sieng Khor, Nurul-Farhana Mohd-Rahim, Habibi Hassan, Josephine Rebecca Chandren, Siti-Sarah Nore, Jefree Johari, Shih-Keng Loong, Juraina Abd-Jamil, Jing-Jing Khoo, Hai-Yen Lee, Brian L Pike, Li Ping Wong, Yvonne Ai-Lian Lim, Keivan Zandi, Sazaly AbuBakar
Q fever is a disease caused by Coxiella burnetii. It is a disease of public health concern in many parts of the world. In this study, we described the seroprevalence of Q fever among selected populations of Orang Asli (OA), indigenous people, many of whom live within the forest fringe areas of Peninsular Malaysia. Serum samples were obtained from 887 OA participants from selected villages. Samples were analyzed for the presence of IgG antibodies reactive against C. burnetii by enzyme-linked immunosorbent assay...
January 16, 2018: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/29336527/sustainable-synthesis-of-oxalic-and-succinic-acid-via-aerobic-oxidation-of-c6-polyols-by-using-m-cnt-ncnt-m-fe-v-based-catalysts-in-mild-conditions
#4
Angela Dibenedetto, Maria Ventura, David Williamson, Francesco Lobefaro, Matthew D Jones, Davide Mattia, Francesco Nocito, Michele Aresta
Sustainable chemical industry encompasses the shift from fossil carbon to renewable carbon. The synthesis of chemicals from non-edible biomass (cellulosic or oily) represents one of the key steps for "greening" the chemical industry. In this paper we report the aerobic oxidation-cleavage of C6 polyols (5-HMF, glucose, fructose, sucrose) in water to oxalic acid-OA (and succinic acid-SA) under mild conditions using M@CNT/NCNT (M=Fe, V; CNT=carbon nanotubes; NCNT= N-doped CNT), which, under suitable conditions, are recoverable and reusable without any loss of efficiency...
January 16, 2018: ChemSusChem
https://www.readbyqxmd.com/read/29336368/glycosaminoglycan-content-of-the-lateral-compartment-cartilage-in-knees-conforming-to-the-indications-for-oxford-medial-unicompartmental-knee-arthroplasty
#5
Fu-Yin Wan, Ju-An Yue, Wan-Shou Guo, Lu-Yao Ma, Ran Yan, Qi-Dong Zhang, Li-Ming Cheng
BACKGROUND: The quality of the lateral compartment cartilage is important to preoperative evaluation and prognostic prediction of unicompartmental knee arthroplasty (UKA). Delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) enables noninvasive assessment of glycosaminoglycan (GAG) content in cartilage. This study aimed to determine the GAG content of the lateral compartment cartilage in knees scheduled to undergo Oxford medial UKA. METHODS: From December 2016 to May 2017, twenty patients (20 osteoarthritic knees) conforming to the indications for Oxford medial UKA were included as the osteoarthritis (OA) group, and 20 healthy volunteers (20 knees) paired by sex, knee side, age (±3 years), and body mass index (BMI) (±3 kg/m2) were included as the control group...
January 20, 2018: Chinese Medical Journal
https://www.readbyqxmd.com/read/29335849/differential-expression-of-adipokines-in-knee-osteoarthritis-patients-with-and-without-metabolic-syndrome
#6
Ning Dong, Yu-Hang Gao, Bo Liu, Cheng-Wu Zhao, Chen Yang, Shu-Qiang Li, Jian-Guo Liu, Xin Qi
PURPOSE: The purpose of this study was to compare adipokines levels in plasma and synovial fluid (SF) between knee osteoarthritis (OA) patients with and without metabolic syndrome (MetS), and to evaluate the associations between adipokines levels and clinical severity of knee osteoarthritis. METHODS: Eighty female patients with knee osteoarthritis were enrolled in the study. These patients were divided into two groups: patients with and without MetS. Clinical severity was evaluated according to visual analogue scale (VAS) pain scores and Western Ontario McMaster University Osteoarthritis Index (WOMAC) scores...
January 15, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29335493/biophysical-feedbacks-mediate-carbonate-chemistry-in-coastal-ecosystems-across-spatiotemporal-gradients
#7
Nyssa J Silbiger, Cascade J B Sorte
Ocean acidification (OA) projections are primarily based on open ocean environments, despite the ecological importance of coastal systems in which carbonate dynamics are fundamentally different. Using temperate tide pools as a natural laboratory, we quantified the relative contribution of community composition, ecosystem metabolism, and physical attributes to spatiotemporal variability in carbonate chemistry. We found that biological processes were the primary drivers of local pH conditions. Specifically, non-encrusting producer-dominated systems had the highest and most variable pH environments and the highest production rates, patterns that were consistent across sites spanning 11° of latitude and encompassing multiple gradients of natural variability...
January 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29334672/oxidative-and-interactive-challenge-of-cadmium-and-ocean-acidification-on-the-smooth-scallop-flexopecten-glaber
#8
Alessandro Nardi, Maura Benedetti, Daniele Fattorini, Francesco Regoli
Ocean acidification (OA) may affect sensitivity of marine organisms to metal pollution modulating chemical bioavailability, bioaccumulation and biological responsiveness of several cellular pathways. In this study, the smooth scallop Flexopecten glaber was exposed to various combinations of reduced pH (pH/pCO2 7.4/∼3000 μatm) and Cd (20 μg/L). The analyses on cadmium uptake were integrated with those of a wide battery of biomarkers including metallothioneins, single antioxidant defenses and total oxyradical scavenging capacity in digestive gland and gills, lysosomal membrane stability and onset of genotoxic damage in haemocytes...
January 8, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29332761/exercise-on-balance-and-function-for-knee-osteoarthritis-a%C3%A2-randomized-controlled-trial
#9
Roberta de Matos Brunelli Braghin, Elisa Cavalheiro Libardi, Carina Junqueira, Marcello Henrique Nogueira-Barbosa, Daniela Cristina Carvalho de Abreu
OBJECTIVES: To assess balance and function of symptomatic and asymptomatic subjects with knee osteoarthritis (OA) and investigate the influence of physical exercise. DESIGN: Subjects were divided into three groups: Group 1 (n = 15), symptomatic knee OA; Group 2 (n = 11), asymptomatic knee OA; and Group 3 (n = 16), knee OA and no intervention. History of falls, the WOMAC questionnaire, balance and functionality were assessed. RESULTS: After intervention, there was a significant difference in the total WOMAC score and in the pain and function domains only in Group 1...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332754/conservative-management-of-thumb-carpometacarpal-osteoarthritis-an-italian-survey-of-current-clinical-practice
#10
Jorge Hugo Villafañe, Kristin Valdes, Virginia O'Brien, Monica Seves, Raquel Cantero-Téllez, Pedro Berjano
OBJECTIVE: The purpose of this study was to elucidate expert opinion on the conservative treatment of thumb carpometacarpal (CMC) joint osteoarthritis (OA). METHODS: A 21-item survey to determine the practice patterns of Italian hand therapists who treat arthritis of the CMC joint was developed and distributed through a professional online survey service to assure confidentiality and anonymity. RESULTS: Of the respondents, 80.8% were physical therapists; the remaining 19...
January 2018: Journal of Bodywork and Movement Therapies
https://www.readbyqxmd.com/read/29332602/nanoemulsion-strategy-for-ursolic-and-oleanic-acids-isolates-from-plumeria-obtusa-improves-antioxidant-and-cytotoxic-activity-in-melanoma-cells
#11
Helen L Alvarado, Ana C Calpena, Maria L Garduno-Ramirez, Raul Ortiz, Consolacion Melguizo, Jose M Prados, Beatriz Clares
BACKGROUND: Triterpenoids are an important class of natural bioactive products present in many medicinal plants. OBJECTIVE: The aim of present study is to investigate the antioxidant and anticarcinogenic potential of oleanolic acid (OA) and ursolic acid (UA) on B16 murine melanoma cell line isolated from Plumeria obtusa, free and loaded in a nanoemulsion (NEm) system. METHOD: The nanoemulsion was characterized by dynamic light scattering, transmission electron microscopy...
January 11, 2018: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29332174/a-friend-in-knee-ccn3-may-inhibit-osteoarthritis-progression
#12
Alex Peidl
Osteoarthritis (OA) is a major clinical problem among the ageing population, yet no disease-modifying treatments currently exist. This issue arises, in part, due to the complex processes occurring in the microenvironment of articular cartilage that lead to osteoarthritic changes. Gaining a better understanding of these processes is crucial in developing a viable therapy for OA. A recent report in Journal of Bone Mineral Metabolism by Janune et al. (J Bone Miner Metab 35:582-597, 2016) suggests a novel role for CCN3 in maintaining the differentiated phenotype of articular cartilage...
January 13, 2018: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/29331994/acl-and-meniscal-injuries-increase-the-risk-of-primary-total-knee-replacement-for-osteoarthritis-a-matched-case-control-study-using-the-clinical-practice-research-datalink-cprd
#13
Tanvir Khan, Abtin Alvand, Daniel Prieto-Alhambra, David J Culliford, Andrew Judge, William F Jackson, Brigitte E Scammell, Nigel K Arden, Andrew James Price
OBJECTIVES: The aim of this study was to investigate whether ACL injury (ACLi) or meniscal injury increases the risk of end-stage osteoarthritis (OA) resulting in total knee replacement (TKR). METHODS: A matched case-control study of all TKRs performed in the UK between January 1990 and July 2011 and recorded in the Clinical Practice Research Datalink (CPRD) was undertaken. The CPRD contains longitudinal data on approximately 3.6 million patients. Two controls were selected for each case of TKR, matched on age, sex and general practitioner location as a proxy for socioeconomic status...
January 13, 2018: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/29331857/baicalin-alleviates-il-1%C3%AE-induced-inflammatory-injury-via-down-regulating-mir-126-in-chondrocytes
#14
Xirui Yang, Qi Zhang, Zhaomeng Gao, Chunyan Yu, Lei Zhang
Baicalin is a flavonoid extracted from Scutellaria baicalensis Georgi, with anti-inflammatory and anti-apoptotic activities. The objective of this study was to explore the effect and mechanism of baicalin on chondrocyte inflammatory response in OA. Different concentrations of IL-1β (0, 0.1, 2, 5 and 10 ng/mL) were used to simulate inflammatory injury in CHON-001 cells. The expression of miR-126 was altered by transfection with miR-126 mimic. Thereafter, cells were treated with baicalin, and cell viability, apoptosis, the expressions of apoptosis-related protein and pro-inflammatory factors were respectively detected using CCK-8 assay, flow cytometry, qRT-PCR and western blot analysis...
January 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29331740/development-and-validation-of-a-new-population-based-simulation-model-of-osteoarthritis-in-new-zealand
#15
Ross Wilson, J Haxby Abbott
OBJECTIVE: To describe the construction and preliminary validation of a new population-based microsimulation model developed to analyse the health and economic burden and cost-effectiveness of treatments for knee osteoarthritis (OA) in New Zealand (NZ). METHOD: We developed the New Zealand Management of Osteoarthritis (NZ-MOA) model, a discrete-time state-transition microsimulation model of the natural history of radiographic knee OA. In this article, we report on the model structure, derivation of input data, validation of baseline model parameters against external data sources, and validation of model outputs by comparison of the predicted population health loss with previous estimates...
January 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29331588/antagonism-of-cysteinyl-leukotriene-receptor-1-cysltr1-by-montelukast-suppresses-cell-senescence-of-chondrocytes
#16
Wei Song, Yumin Zhang, Jun Wang, Tao Ma, Linjie Hao, Kunzheng Wang
Aging is closely associated with osteoarthritis (OA). Although its underlying mechanisms remain unknown, cellular senescence in chondrocytes has become an important therapeutic target for the treatment of OA. Cysteinyl leukotriene receptors (cysLTRs) mediate the pathobiological function of cysteinyl leukotrienes (cysLTs). However, the roles of cysLTRs in the pathogenesis of OA have not been reported before. In the current study, we found that cysLTR1 but not cysLTR2 is expressed in human primary chondrocytes...
January 10, 2018: Cytokine
https://www.readbyqxmd.com/read/29331302/bone-matrix-microdamage-and-vascular-changes-characterize-bone-marrow-lesions-in-the-subchondral-bone-of-knee-osteoarthritis
#17
Dzenita Muratovic, David M Findlay, Flavia M Cicuttini, Anita E Wluka, Yea-Rin Lee, Julia S Kuliwaba
INTRODUCTION: Bone marrow lesions (BMLs) in the subchondral bone in osteoarthritis (OA) are suggested to be multifactorial, although the pathogenic mechanisms are unknown. Bone metabolism and cardiovascular risk factors associate with BML in epidemiologic studies. However, there are no studies at the tissue level investigating the relationship between these processes and BML. The aim of this study was to investigate the relationship between BMLs in the tibial plateau (TP) of knee OA and bone matrix microdamage, osteocyte density and vascular changes...
January 10, 2018: Bone
https://www.readbyqxmd.com/read/29331208/wrist-a-wrist-image-segmentation-toolkit-for-carpal-bone-delineation-from-mri
#18
Brent Foster, Anand A Joshi, Marissa Borgese, Yasser Abdelhafez, Robert D Boutin, Abhijit J Chaudhari
Segmentation of the carpal bones from 3D imaging modalities, such as magnetic resonance imaging (MRI), is commonly performed for in vivo analysis of wrist morphology, kinematics, and biomechanics. This crucial task is typically carried out manually and is labor intensive, time consuming, subject to high inter- and intra-observer variability, and may result in topologically incorrect surfaces. We present a method, WRist Image Segmentation Toolkit (WRIST), for 3D semi-automated, rapid segmentation of the carpal bones of the wrist from MRI...
December 28, 2017: Computerized Medical Imaging and Graphics: the Official Journal of the Computerized Medical Imaging Society
https://www.readbyqxmd.com/read/29331039/expression-of-chemerin-in-the-synovial-fluid-of-patients-with-temporomandibular-joint-disorders
#19
Göksel Şimşek Kaya, Günay Yapıcı Yavuz, Ahmet Kızıltunç
The synovial membrane and fluid are significantly involved in the pathogenesis of temporomandibular joint (TMJ) disorders. This study aimed to investigate the relation between levels of chemerin in the synovial fluid (SF) of patients with TMJ disorder and their relationship. Sixty samples of SF were obtained from patients with an internal derangement (ID) or osteoarthritis (OA). Chemerin in the SF was examined by enzyme-linked immunosorbent assay (ELISA). The results showed greater levels of chemerin in the SF of patients with OA than ID...
January 13, 2018: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/29330103/osteoarthritis-year-in-review-2017-rehabilitation-and-outcomes
#20
REVIEW
Dieuwke Schiphof, Jacoline J van den Driest, Jos Runhaar
OBJECTIVE: The purpose of this systematic review was to describe studies examining rehabilitation for people with osteoarthritis (OA) and to summarize findings from selected key systematic reviews (SRs) and randomized controlled trials (RCTs). DESIGN: A systematic search was performed using Pubmed, Embase and Cochrane databases from April 1st 2016 to May 15th 2017 using the terms 'osteoarthritis', 'randomized controlled trial', and 'systematic review'. Inclusion criteria were: clinically or radiologically diagnosed patients with osteoarthritis, rehabilitation treatment, RCT or SRs...
January 9, 2018: Osteoarthritis and Cartilage
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