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https://www.readbyqxmd.com/read/29443485/effectiveness-of-the-canrisk-tool-in-the-identification-of-dysglycemia-in-first-nations-and-m%C3%A3-tis-in-canada
#1
Gina Agarwal, Ying Jiang, Susan Rogers Van Katwyk, Chantal Lemieux, Heather Orpana, Yang Mao, Brandan Hanley, Karen Davis, Laurel Leuschen, Howard Morrison
INTRODUCTION: First Nations/Métis populations develop diabetes earlier and at higher rates than other Canadians. The Canadian diabetes risk questionnaire (CANRISK) was developed as a diabetes screening tool for Canadians aged 40 years or over. The primary aim of this paper is to assess the effectiveness of the existing CANRISK tool and risk scores in detecting dysglycemia in First Nations/Métis participants, including among those under the age of 40. A secondary aim was to determine whether alternative waist circumference (WC) and body mass index (BMI) cut-off points improved the predictive ability of logistic regression models using CANRISK variables to predict dysglycemia...
February 2018: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/29441827/urinary-bisphenol-a-concentrations-in-relation-to-asthma-in-a-sample-of-egyptian-children
#2
M M Youssef, Ems El-Din, M M AbuShady, N R El-Baroudy, T A Abd El Hamid, A F Armaneus, A S El Refay, J Hussein, D Medhat, Y A Latif
BACKGROUND: Bronchial asthma is one of the top disabling diseases in pediatrics. Limited research has been studied the association of the widely used plastic monomer bisphenol A (BPA) with childhood asthma. OBJECTIVE: To compare the levels of urinary BPA in asthmatic and control children and to investigate the implication of BPA among other risk factors for the development of asthma. SUBJECTS AND METHODS: This case-control study included 97 children (45 asthmatic and 52 healthy controls) aged 3-8 years...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29439927/characterization-of-pharmacists-interventions-in-asthma-management-a-systematic-review
#3
REVIEW
Carmen Crespo-Gonzalez, Fernando Fernandez-Llimos, Inajara Rotta, Cassyano J Correr, Shalom I Benrimoj, Victoria Garcia-Cardenas
OBJECTIVE: Pharmacists have adopted an active role in asthma management. This review aimed to analyze the intervention dose, understood as the "amount of program delivered," and core components of the intervention provided by pharmacists in asthma management. DATA SOURCES: A literature search was conducted in December 2016 using PubMed. STUDY SELECTION: A 2-stage approach was used. At the first stage, systematic reviews of pharmacists' interventions in asthma management were identified...
February 10, 2018: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/29439404/high-fat-diet-induced-obesity-produces-spontaneous-ventricular-arrhythmias-and-increases-the-activity-of-ryanodine-receptors-in-mice
#4
Gina Sánchez, Felipe Araneda, Juan Pedro Peña, José Pablo Finkelstein, Jaime A Riquelme, Luis Montecinos, Genaro Barrientos, Paola Llanos, Zully Pedrozo, Matilde Said, Ricardo Bull, Paulina Donoso
Ventricular arrhythmias are a common cause of sudden cardiac death, and their occurrence is higher in obese subjects. Abnormal gating of ryanodine receptors (RyR2), the calcium release channels of the sarcoplasmic reticulum, can produce ventricular arrhythmias. Since obesity promotes oxidative stress and RyR2 are redox-sensitive channels, we investigated whether the RyR2 activity was altered in obese mice. Mice fed a high fat diet (HFD) became obese after eight weeks and exhibited a significant increase in the occurrence of ventricular arrhythmias...
February 10, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29437984/differences-in-experiences-of-barriers-to-sti-testing-between-clients-of-the-internet-based-diagnostic-testing-service-getcheckedonline-com-and-an-sti-clinic-in-vancouver-canada
#5
Mark Gilbert, Kimberly Thomson, Travis Salway, Devon Haag, Troy Grennan, Christopher K Fairley, Chris Buchner, Mel Krajden, Perry Kendall, Jean Shoveller, Gina Ogilvie
OBJECTIVES: Internet-based STI testing programmes may overcome barriers posed by in-clinic testing, though uptake could reflect social gradients. The role these services play in comparison to clinical testing services is unknown. We compared experiences of testing barriers between STI clinic clients to clients of GetCheckedOnline.com (GCO; where clients take a printed lab form to a lab). METHODS: Our 10-month cross-sectional study was conducted after GCO was promoted to STI clinic clients and men who have sex with men (MSM)...
February 7, 2018: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29437940/the-effect-of-text-messaging-on-latent-tuberculosis-treatment-adherence-a-randomised-controlled-trial
#6
James C Johnston, Mia L van der Kop, Kirsten Smillie, Gina Ogilvie, Fawziah Marra, Mohsen Sadatsafavi, Kamila Romanowski, Matthew A Budd, Jan Hajek, Victoria Cook, Richard T Lester
There is limited high-quality evidence available to inform the use of text messaging to improve latent tuberculosis infection (LTBI) treatment adherence.We performed a parallel, randomised controlled trial at two sites to assess the effect of a two-way short message service on LTBI adherence. We enrolled adults initiating LTBI therapy from June 2012 to September 2015 in British Columbia, Canada. Participants were randomised in a 1:1 ratio to standard LTBI treatment (control) or standard LTBI treatment plus two-way weekly text messaging (intervention)...
February 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29436764/environmental-variation-shifts-the-relationship-between-trees-and-scatterhoarders-along-the-continuum-from-mutualism-to-antagonism
#7
Gina M Sawaya, Adam S Goldberg, Michael A Steele, Harmony J Dalgleish
The conditional mutualism between scatterhoarders and trees varies on a continuum from mutualism to antagonism and can change across time, space, and among species. We examined four tree species (red oak [Quercus rubra], white oak [Q. alba], American chestnut [Castanea dentata] and hybrid chestnut [C. dentata x C. mollissima) across five sites and three years to quantify the variability in this conditional mutualism. We used a published model to compare the rates of seed emergence with and without burial to the probability that seeds will be cached and left uneaten by scatterhoarders in order to quantify variation in the conditional mutualism that can be explained by environmental variation among sites, years, species, and seed provenance within species...
February 13, 2018: Integrative Zoology
https://www.readbyqxmd.com/read/29433321/structural-characterization-of-self-assembling-hybrid-nanoparticles-for-bisphosphonate-delivery-in-tumors
#8
Sandra Ristori, Isabelle Grillo, Sara Lusa, Jana Thamm, Gina Valentino, Virginia Campani, Michele Caraglia, Frank Steiniger, Paola Luciani, Giuseppe De Rosa
Hybrid self-assembling nanoparticles (hsaNPs) encapsulating bisphosphonates (BPs) recently showed very promising results in preclinic experiments for the treatment of brain tumor. However, the poor knowledge on the architecture of hybrid nanovectors is certainly one of the main reasons hampering further clinical and industrial development of these technologies. Here we propose to combine different techniques, i.e. Small Angle Neutron Scattering (SANS) and X-ray Scattering (SAXS), with cryo-Electron Transmission Microscopy (cryo-TEM) to study the architecture of the final hsaNPs as well as of the four components before the assembling process...
February 12, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29431450/advanced-nmr-based-structural-investigation-of-glucosinolates-and-desulfoglucosinolates
#9
Nada Ibrahim, Ingrid Allart-Simon, Gina R De Nicola, Renato Iori, Jean-Hugues Renault, Patrick Rollin, Jean-Marc Nuzillard
Glucosinolates (GLs) constitute a class of plant secondary metabolites that are characteristic of the order Brassicales. They each contain a common hydrophilic moiety connected to a mostly hydrophobic side chain whose constitution is the most frequent structural variant. Their transformations by myrosinases lead to intensively studied and highly reactive compounds of biological relevancy. In other respects, the enzymatic desulfation of GLs produces derivatives (DS-GLs) that are useful for GL analysis. A collection of 31 compounds, GLs and DS-GLs, representing 17 different side chains was established in order to report accurate descriptions of the molecules' 1H-, 13C-, and 15N-NMR parameters...
February 12, 2018: Journal of Natural Products
https://www.readbyqxmd.com/read/29429747/treatment-of-corneal-chemical-alkali-burns-with-a-crosslinked-thiolated-hyaluronic-acid-film
#10
Gina L Griffith, Barbara Wirostko, Hee-Kyoung Lee, Lauren E Cornell, Jennifer S McDaniel, David O Zamora, Anthony J Johnson
PURPOSE: The study objective was to test the utilization of a crosslinked, thiolated hyaluronic acid (CMHA-S) film for treating corneal chemical burns. METHODS: Burns 5.5mm in diameter were created on 10 anesthetized, male New Zealand white rabbits by placing a 1N NaOH soaked circular filter paper onto the cornea for 30s. Wounds were immediately rinsed with balanced salt solution (BSS). CMHA-S films were placed in the left inferior fornix of five injured and five uninjured animals...
February 8, 2018: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/29428621/the-chss-complete-atrioventricular-septal-defect-cohort-baseline-pre-intervention-echocardiographic-characteristics
#11
James M Meza, Paul J Devlin, David M Overman, David Gremmels, Gina Baffa, Meryl S Cohen, Michael D Quartermain, Christopher A Caldarone, Kamal Pourmoghadam, William M DeCampli, Cheryl T Fackoury, Luc Mertens
OBJECTIVE: Quantifying unbalance, the threshold for single ventricle palliation vs biventricular repair in patients with unbalanced complete atrioventricular septal defect (AVSD), is challenging. Utilizing a core lab review of baseline echocardiograms, we sought to assess the correlations among commonly used measures of unbalance and common atrioventricular valve (AVV) and ventricular sizes. METHODS: A single reviewer evaluated baseline echocardiograms from an inception cohort of babies < age 1 year with complete AVSD admitted to one of 25 CHSS institutions...
February 8, 2018: Seminars in Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29425781/single-fluid-filled-intragastric-balloon-safe-and-effective-for-inducing-weight-loss-in-a-real-world-population
#12
Eric J Vargas, Carl M Pesta, Ahmad Bali, Eric Ibegbu, Fateh Bazerbachi, Rachel L Moore, Vivek Kumbhari, Reem Z Sharaiha, Trace W Curry, Gina DosSantos, Ramsey Schmitz, Abhishek Agnihotri, Aleksey A Novikov, Tracy Pitt, Margo K Dunlap, Andrea Herr, Louis Aronne, Erin Ledonne, Hoda C Kadouh, Lawrence J Cheskin, Manpreet S Mundi, Andres Acosta, Christopher J Gostout, Barham K Abu Dayyeh
BACKGROUND & AIMS: The Orbera Intragastric Balloon (OIB) is a single fluid-filled intra-gastric balloon approved for induction of weight loss and treatment of obesity. However, little is known about the effectiveness and safety of outside clinical trials, and since approval, the Food and Drug Administration has issued warnings to healthcare providers about risk of balloon hyper-inflation requiring early removal, pancreatitis, and death. We analyzed data on patients who have received the OIB since its approval determine its safety, effectiveness, and tolerance in real-world clinical settings...
February 6, 2018: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29423380/firewalls-prevent-systemic-dissemination-of-vectors-derived-from-human-adenovirus-type-5-and-suppress-production-of-transgene-encoded-antigen-in-a-murine-model-of-oral-vaccination
#13
Julien Revaud, Yves Unterfinger, Nicolas Rol, Muhammad Suleman, Julia Shaw, Sandra Galea, Françoise Gavard, Sandrine A Lacour, Muriel Coulpier, Nicolas Versillé, Menzo Havenga, Bernard Klonjkowski, Gina Zanella, Stéphane Biacchesi, Nathalie Cordonnier, Blaise Corthésy, Juliette Ben Arous, Jennifer P Richardson
To define the bottlenecks that restrict antigen expression after oral administration of viral-vectored vaccines, we tracked vectors derived from the human adenovirus type 5 at whole body, tissue, and cellular scales throughout the digestive tract in a murine model of oral delivery. After intragastric administration of vectors encoding firefly luciferase or a model antigen, detectable levels of transgene-encoded protein or mRNA were confined to the intestine, and restricted to delimited anatomical zones. Expression of luciferase in the form of multiple small bioluminescent foci in the distal ileum, cecum, and proximal colon suggested multiple crossing points...
2018: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29420415/delayed-presentation-of-cecal-perforation-with-tension-free-vaginal-tape
#14
Allison C Mayhew, Alexcis T Ford, Gina M Northington, Virginia O Shaffer, Robert S Kelley
BACKGROUND: Tension-free vaginal tape (TVT) is a popular operative treatment for stress urinary incontinence (SUI). It has a low risk of adverse events, and injuries, particularly to the bowel, are rare. Case reports that have previously discussed these injuries and subsequent removal of TVT have not provided additional insight into management of SUI after these injuries occur. CASE: A postmenopausal woman with persistent SUI presented more than 1 year after TVT placement with bowel perforation incidentally discovered on routine screening colonoscopy...
February 5, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29420096/gamma-globulin-replacement-therapy-in-uncontrolled-severe-asthma-associated-with-humoral-immunodeficiency-a-series-of-five-case-reports
#15
Angelica Tiotiu, Yves Martinet, Roger Jankowski, Philippe Devillier
We report on five adult cases of the rare association of asthma with humoral immunodeficiency (huID). All patients had uncontrolled asthma related to recurrent respiratory infections. Asthma was diagnosed according to the Global Initiative for Asthma (GINA) guidelines, and bronchiectasis was ruled out by a CT chest scan. Two men (aged 28 and 60) presented with pollen allergies, chronic rhinosinusitis, and IgG deficiency (7.8 and 7.6 g/L, respectively). Both patients underwent surgery for nasal polyposis but relapsed with acute sinusitis and severe asthma exacerbations requiring treatment with oral corticosteroids and antibiotics...
February 8, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29414685/the-small-intestine-converts-dietary-fructose-into-glucose-and-organic-acids
#16
Cholsoon Jang, Sheng Hui, Wenyun Lu, Alexis J Cowan, Raphael J Morscher, Gina Lee, Wei Liu, Gregory J Tesz, Morris J Birnbaum, Joshua D Rabinowitz
Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical feature of sweets is fructose. Despite strong ties between fructose and disease, the metabolic fate of fructose in mammals remains incompletely understood. Here we use isotope tracing and mass spectrometry to track the fate of glucose and fructose carbons in vivo, finding that dietary fructose is cleared by the small intestine. Clearance requires the fructose-phosphorylating enzyme ketohexokinase. Low doses of fructose are ∼90% cleared by the intestine, with only trace fructose but extensive fructose-derived glucose, lactate, and glycerate found in the portal blood...
February 6, 2018: Cell Metabolism
https://www.readbyqxmd.com/read/29414545/assessing-the-impact-of-caring-for-a-child-with-dravet-syndrome-results-of-a-caregiver-survey
#17
Jonathan D Campbell, Melanie D Whittington, Chong H Kim, Gina R VanderVeen, Kelly G Knupp, Arnold Gammaitoni
OBJECTIVE: The objective of this study was to describe and quantify the impact of caring for a child with Dravet syndrome (DS) on caregivers. METHODS: We surveyed DS caregivers at a single institution with a large population of patient with DS. Survey domains included time spent/difficulty performing caregiving tasks (Oberst Caregiving Burden Scale, OCBS); caregiver health-related quality of life (EuroQoL 5D-5L, EQ-5D); and work/activity impairment (Work Productivity and Activity Impairment questionnaire, WPAI)...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29414539/the-direct-and-indirect-costs-of-dravet-syndrome
#18
Melanie D Whittington, Kelly G Knupp, Gina Vanderveen, Chong Kim, Arnold Gammaitoni, Jonathan D Campbell
OBJECTIVE: The objective of this study was to estimate the annual direct and indirect costs associated with Dravet Syndrome (DS). METHODS: A survey was electronically administered to the caregivers of patients with DS treated at Children's Hospital Colorado. Survey domains included healthcare utilization of the patient with DS and DS caregiver work productivity and activity impairment. Patient healthcare utilization was measured using modified questions from the National Health Interview Survey; caregiver work productivity and activity impairment were measured using modified questions from the Work Productivity and Activity Impairment questionnaire...
February 1, 2018: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/29414311/gene-expression-analysis-subcellular-localization-and-in-planta-antimicrobial-activity-of-rice-oryza-sativa-l-defensin-7-and-8
#19
Kamonwan Weerawanich, Gina Webster, Julian K-C Ma, Waranyoo Phoolcharoen, Supaart Sirikantaramas
Defensins are a group of plant antimicrobial peptides. In a previous study, it was reported that two recombinant rice (Oryza sativa L.) defensin (OsDEF) genes (OsDEF7 and OsDEF8) produced heterologously by bacteria inhibited the growth of several phytopathogen. Here, we analyzed gene expression patterns in Thai jasmine rice (O. sativa L. ssp. indica 'KDML 105') using quantitative reverse transcription-polymerase chain reaction and compared them with those in Japanese rice (O. sativa L. ssp. japonica 'Nipponbare')...
January 30, 2018: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/29412832/alpha-cell-dysfunction-in-type-1-diabetes
#20
REVIEW
Gina L C Yosten
Type 1 diabetes is characterized by selective loss of beta cells and insulin secretion, which significantly impact glucose homeostasis. However, this progressive disease is also associated with dysfunction of the alpha cell component of the islet, which can exacerbate hyperglycemia due to paradoxical hyperglucagonemia or lead to severe hypoglycemia as a result of failed counterregulation. In this review, the physiology of alpha cell secretion and the potential mechanisms underlying alpha cell dysfunction in type 1 diabetes will be explored...
February 2018: Peptides
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