keyword
MENU ▼
Read by QxMD icon Read
search

GINA

keyword
https://www.readbyqxmd.com/read/28821740/irs4-a-novel-modulator-of-bmp-smad-and-akt-signalling-during-early-muscle-differentiation
#1
Gina Dörpholz, Arunima Murgai, Jerome Jatzlau, Daniel Horbelt, Mohammad Poorgholi Belverdi, Christina Heroven, Isabelle Schreiber, Gisela Wendel, Karen Ruschke, Sigmar Stricker, Petra Knaus
Elaborate regulatory networks of the Bone Morphogenetic Protein (BMP) pathways ensure precise signalling outcome during cell differentiation and tissue homeostasis. Here, we identified IRS4 as a novel regulator of BMP signal transduction and provide molecular insights how it integrates into the signalling pathway. We found that IRS4 interacts with the BMP receptor BMPRII and specifically targets Smad1 for proteasomal degradation consequently leading to repressed BMP/Smad signalling in C2C12 myoblasts while concomitantly activating the PI3K/Akt axis...
August 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28819540/use-of-global-initiative-for-asthma-gina-guidelines-in-asthma-management-among-paediatric-residents-in-a-sub-saharan-african-country-a-cross-sectional-descriptive-study
#2
Adaeze Chikaodinaka Ayuk, Agozie Ubesie, Chioma Laura Odimegwu, Kenechukwu Iloh
INTRODUCTION: Clinical practice guidelines are systematically developed statements to assist practitioner and patient decisions about appropriate health care for specific clinical circumstances. Despite abundance of asthma guidelines, prevalence has continued to increase globally. There is need to assess how the contents of asthma guidelines are put to clinical use by doctors in the management of children with asthma. This study aims at evaluating the clinical practice of paediatric residents in applying GINA guidelines...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28815007/appropriate-selection-for-omalizumab-treatment-in-patients-with-severe-asthma
#3
Leo Nygaard, Daniel Pilsgaard Henriksen, Hanne Madsen, Jesper Rømhild Davidsen
Background: Omalizumab improves asthma control in patients with uncontrolled severe allergic asthma; however, appropriate patient selection is crucial. Information in this field is sparse. Objective: We aimed to estimate whether potential omalizumab candidates were appropriately selected according to guidelines, and the clinical effect of omalizumab treatment over time. Design: We performed a retrospective observational study on adult patients with asthma treated with omalizumab during 2006-2015 at the Department of Respiratory Medicine at Odense University Hospital (OUH), Denmark...
2017: European Clinical Respiratory Journal
https://www.readbyqxmd.com/read/28814674/rilonacept-maintains-long-term-inflammatory-remission-in-patients-with-deficiency-of-the-il-1-receptor-antagonist
#4
Megha Garg, Adriana A de Jesus, Dawn Chapelle, Paul Dancey, Ronit Herzog, Rafael Rivas-Chacon, Theresa L Wampler Muskardin, Ann Reed, James C Reynolds, Raphaela Goldbach-Mansky, Gina A Montealegre Sanchez
BACKGROUND: Deficiency of IL-1 receptor antagonist (DIRA) is a rare autoinflammatory disease that presents with life-threatening systemic inflammation, aseptic multifocal osteomyelitis, and pustulosis responsive to IL-1-blocking treatment. This study was performed (a) to investigate rilonacept, a long-acting IL-1 inhibitor, in maintaining anakinra-induced inflammatory remission in DIRA patients, (b) to determine doses needed to maintain remission, and (c) to evaluate the safety and pharmacokinetics of rilonacept in young children (<12 years)...
August 17, 2017: JCI Insight
https://www.readbyqxmd.com/read/28814418/comparing-glaucomatous-disc-change-using-stereo-disc-viewing-and-the-matchedflicker-programme-in-glaucoma-experts-and-trainees
#5
Jamie L Schaefer, Alissa M Meyer, Cooper D Rodgers, Nicole C Rosenberg, Anthony J Leoncavallo, Zachary L Lukowski, Anthony B Greer, Gina M Martorana, Baiming Zou, Jonathan J Shuster, L Jay Katz, Joel S Schuman, Michael A Kass, Mark B Sherwood
BACKGROUND/AIMS: The objective of this study is to evaluate the accuracy and speed of trainees and experienced glaucoma specialists using the MatchedFlicker software against the manual examination of stereoscopic disc photographs for detecting glaucomatous optic disc change. METHODS: Three experienced glaucoma specialists, two resident ophthalmologists and one glaucoma fellow from multiple institutions independently evaluated the same 140 image pairs from 100 glaucomatous/ocular hypertensive eyes using a handheld stereo viewer and the MatchedFlicker programme...
August 16, 2017: British Journal of Ophthalmology
https://www.readbyqxmd.com/read/28812409/tumor-reduction-and-symptom-relief-after-electrochemotherapy-in-a-patient-with-aggressive-fibromatosis-a-case-report
#6
Joanna Vitfell-Rasmussen, Rikke Mulvad Sandvik, Karin Dahlstrøm, Gina Al-Farra, Anders Krarup-Hansen, Julie Gehl
No abstract text is available yet for this article.
August 16, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28808559/reproductive-cycles-in-tropical-intertidal-gastropods-are-timed-around-tidal-amplitude-cycles
#7
Rachel Collin, Kecia Kerr, Gina Contolini, Isis Ochoa
Reproduction in iteroparous marine organisms is often timed with abiotic cycles and may follow lunar, tidal amplitude, or daily cycles. Among intertidal marine invertebrates, decapods are well known to time larval release to coincide with large amplitude nighttime tides, which minimizes the risk of predation. Such bimonthly cycles have been reported for few other intertidal invertebrates. We documented the reproduction of 6 gastropod species from Panama to determine whether they demonstrate reproductive cycles, whether these cycles follow a 2-week cycle, and whether cycles are timed so that larval release occurs during large amplitude tides...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28808554/arthropod-communities-on-hybrid-and-parental-cottonwoods-are-phylogenetically-structured-by-tree-type-implications-for-conservation-of-biodiversity-in-plant-hybrid-zones
#8
Karl J Jarvis, Gerard J Allan, Ashley J Craig, Rebecca K Beresic-Perrins, Gina Wimp, Catherine A Gehring, Thomas G Whitham
Although hybridization in plants has been recognized as an important pathway in plant speciation, it may also affect the ecology and evolution of associated communities. Cottonwood species (Populus angustifolia and P. fremontii) and their naturally occurring hybrids are known to support different plant, animal, and microbial communities, but no studies have examined community structure within the context of phylogenetic history. Using a community composed of 199 arthropod species, we tested for differences in arthropod phylogenetic patterns within and among hybrid and parental tree types in a common garden...
August 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/28807788/adolescent-binge-ethanol-exposure-alters-specific-forebrain-cholinergic-cell-populations-and-leads-to-selective-functional-deficits-in-the-prefrontal-cortex
#9
Gina M Fernandez, Lisa M Savage
Adolescence has been identified as a vulnerable developmental time period during which exposure to drugs can have long-lasting, detrimental effects. Although adolescent binge-like ethanol (EtOH) exposure leads to a significant reduction of forebrain cholinergic neurons, EtOH's functional effect on acetylcholine (ACh) release during behavior has yet to be examined. Using an adolescent intermittent ethanol exposure model (AIE), rats were exposed to binge-like levels of EtOH from postnatal day (PD) 25-55. Three weeks following the final EtOH exposure, cholinergic functioning was assessed during a spontaneous alternation protocol...
August 11, 2017: Neuroscience
https://www.readbyqxmd.com/read/28806687/mineralization-defects-are-comparable-in-fluorotic-impacted-human-teeth-and-fluorotic-mouse-incisors
#10
Rozita Jalali, Franck Guy, Samaneh Ghazanfari, Don Lyaruu, Leo van Ruijven, Pamela DenBesten, Stefania Martignon, Gina Castiblanco, Antonius L J J Bronckers
OBJECTIVE: Fluoride excess of 0.05-0.07mgF/kgbw/day in water or food additives like salt is the principal cause of endemic dental fluorosis. How fluoride causes these defects is not clear yet. Recent studies in rodents suggest that development of enamel fluorosis is associated with insufficient neutralization of protons released during the formation of hypermineralized lines. DESIGN: Here we examined whether hypermineralization could also be assessed by MicroCT in developing molar enamel of humans exposed to fluoride...
July 29, 2017: Archives of Oral Biology
https://www.readbyqxmd.com/read/28805811/caveolin-1-dependent-nanoscale-organization-of-the-bcr-regulates-b-cell-tolerance
#11
Susana Minguet, Kathrin Kläsener, Anna-Maria Schaffer, Gina J Fiala, Teresa Osteso-Ibánez, Katrin Raute, Inmaculada Navarro-Lérida, Frederike A Hartl, Maximilian Seidl, Michael Reth, Miguel A Del Pozo
Caveolin-1 (Cav1) regulates the nanoscale organization and compartmentalization of the plasma membrane. Here we found that Cav1 controlled the distribution of nanoclusters of isotype-specific B cell antigen receptors (BCRs) on the surface of B cells. In mature B cells stimulated with antigen, the immunoglobulin M BCR (IgM-BCR) gained access to lipid domains enriched for GM1 glycolipids, by a process that was dependent on the phosphorylation of Cav1 by the Src family of kinases. Antigen-induced reorganization of nanoclusters of IgM-BCRs and IgD-BCRs regulated BCR signaling in vivo...
August 14, 2017: Nature Immunology
https://www.readbyqxmd.com/read/28803368/political-affiliation-spirituality-and-religiosity-links-to-emerging-adults-life-satisfaction-and-optimism
#12
Cansu Berivan Ozmen, Gina M Brelsford, Caili R Danieu
The goal of this study was to extend the existing literature regarding the intersection between belief systems shaping psychological processes and subjective well-being among emerging adults. A nationwide sample of 3966 college students reported on their political affiliation, spirituality, and religiosity in relation to their subjective well-being. Multivariate analyses demonstrated that politically conservative participants were significantly more optimistic and satisfied with life than their liberal counterparts and Republican emerging adults reported significantly higher life satisfaction than Democrats...
August 12, 2017: Journal of Religion and Health
https://www.readbyqxmd.com/read/28801057/mothers-loss-of-control-over-eating-during-pregnancy-in-relation-to-their-infants-appetitive-traits
#13
Rachel P Kolko, Rachel H Salk, Gina M Sweeny, Marsha D Marcus, Michele D Levine
No abstract text is available yet for this article.
August 8, 2017: Appetite
https://www.readbyqxmd.com/read/28800337/the-new-zealand-neuromuscular-disease-patient-registry-five-years-and-a-thousand-patients
#14
Miriam J Rodrigues, Gina L O'Grady, Graeme Hammond-Tooke, Alexa Kidd, Donald O Love, Ronelle K Baker, Richard H Roxburgh
The New Zealand Neuromuscular Disease Patient Registry has been recruiting for five years. Its primary aim is to enable people with neuromuscular disease to participate in research including clinical trials. It has contributed data to large anonymised cohort studies and many feasibility studies, and has provided practical information and advice to researchers wanting to work with people with neuromuscular conditions. 1019 people have enrolled since the Registry's launch in August 2011 with over 70 different diagnoses...
August 11, 2017: Journal of Neuromuscular Diseases
https://www.readbyqxmd.com/read/28798148/ubiquitination-of-basal-vegfr2-regulates-signal-transduction-and-endothelial-function
#15
Gina A Smith, Gareth W Fearnley, Izma Abdul-Zani, Stephen B Wheatcroft, Darren C Tomlinson, Michael A Harrison, Sreenivasan Ponnambalam
Cell surface receptors can undergo recycling or proteolysis but the cellular decision-making events that sort between these pathways remain poorly defined. Vascular endothelial growth factor A (VEGF-A) and vascular endothelial growth factor receptor 2 (VEGFR2) regulates signal transduction and angiogenesis but how signaling and proteolysis is regulated is not well understood. Here, we provide evidence that a pathway requiring the E1 ubiquitin-activating enzyme UBA1 controls basal VEGFR2 levels, hence metering plasma membrane receptor availability for the VEGF-A-regulated response by endothelial cells...
August 10, 2017: Biology Open
https://www.readbyqxmd.com/read/28798051/role-of-erosions-typical-of-rheumatoid-arthritis-in-the-2010-acr-eular-rheumatoid-arthritis-classification-criteria-results-from-a-very-early-arthritis-cohort
#16
Gina Hetland Brinkmann, Ellen S Norli, Pernille Bøyesen, Désirée van der Heijde Heijde, Lars Grøvle, Anne J Haugen, Halvor Nygaard, Olav Bjørneboe, Cathrine Thunem, Tore K Kvien, Maria D Mjaavatten, Elisabeth Lie
OBJECTIVE: To determine how the European League Against Rheumatism (EULAR) definition of erosive disease (erosion criterion) contributes to the number of patients classified as rheumatoid arthritis (RA) according to the 2010 American College of Rheumatology/EULAR RA classification criteria (2010 RA criteria) in an early arthritis cohort. METHODS: Patients from the observational study Norwegian Very Early Arthritis Clinic with joint swelling ≤16 weeks, a clinical diagnosis of RA or undifferentiated arthritis, and radiographs of hands and feet were included...
August 10, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28794802/healthy-lifestyle-intervention-for-adult-clinic-patients-with-type-2-diabetes-mellitus
#17
Steven S Coughlin, Christos Hatzigeorgiou, Judith Anglin, Ding Xie, Gina M Besenyi, Gianluca De Leo, Jessica Stewart, Thad Wilkins
BACKGROUND: Diet and exercise therapy have been reported to be effective in improving blood glucose control and are an important part of treatment of type 2 diabetes mellitus. OBJECTIVE: The goal of this study is to examine the efficacy of a healthy lifestyle intervention for adult clinic patients with type 2 diabetes mellitus, as measured by Hgb-A1c, cardiovascular indicators, physical activity, weight, and BMI. Also of interest are optimal strategies for subject recruitment, the number of intervention sessions attended, and participant use of the Fitbit watch to monitor their physical activity and track food and beverage consumption...
2017: Diabetes Management
https://www.readbyqxmd.com/read/28792295/medical-care-at-a-large-vertical-running-event
#18
Christopher J Nash, Christopher T Richards, Gina Schwieger, Sanjeev Malik, George T Chiampas
OBJECTIVE: Vertical running events, during which participants race up the stairwells of skyscrapers, are becoming increasingly popular. Such events have unique and specific operational and clinical considerations for event medical directors, but descriptions of the medical care provided at these events are lacking. We sought to perform a descriptive analysis of the medical care delivered at a single, large vertical running event. METHODS: A retrospective chart review of medical encounters at a large vertical running event from 2011-2017 was performed...
August 9, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28792063/youth-homelessness-and-vulnerability-how-does-couch-surfing-fit
#19
Susanna R Curry, Matthew Morton, Jennifer L Matjasko, Amy Dworsky, Gina M Samuels, David Schlueter
Youth homelessness is a problem characterized by high levels of vulnerability. The extent to which couch surfing - moving from one temporary housing arrangement to another - is part of youth homelessness is not well understood. Chapin Hall's Voices of Youth Count, a national research initiative, involves a multicomponent approach to studying youth homelessness. This study reports emerging findings regarding couch surfing and homelessness primarily from a national survey of 13,113 adults with youth ages 13-25 in their households or who are themselves ages 18-25...
August 9, 2017: American Journal of Community Psychology
https://www.readbyqxmd.com/read/28791208/novel-microsatellite-development-and-characterization-for-phacelia-formosula-hydrophyllaceae
#20
James P Riser, Anna L Schwabe, Jennifer Ramp Neale
PREMISE OF THE STUDY: Microsatellite primers were developed to characterize genetic diversity and structuring in the genus Phacelia (Hydrophyllaceae) and to further conservation efforts for P. formosula. METHODS AND RESULTS: Fifteen novel microsatellite primers were developed for P. formosula. These were characterized for genetic variation in three separate P. formosula populations. Two to nine alleles were found per locus. Overall observed heterozygosity and expected heterozygosity ranged from 0...
July 2017: Applications in Plant Sciences
keyword
keyword
70961
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"