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https://www.readbyqxmd.com/read/29028452/atrial-fibrillation-in-women-risks-and-management
#1
Sindhu Prabakaran, Maria Carolina Gongora Nieto, Gina Lundberg
Atrial fibrillation (AF) is one of the most commonly occurring arrhythmias and a major modifiable risk factor for stroke, especially in women. While its prevalence is similar in both men and women, women unfortunately face a greater intrinsic AF-related risk of stroke than men do. This is likely one of the reasons that more women than men die from strokes, in addition to experiencing more new and recurrent strokes. Therefore, in women especially, it is imperative to diagnose and treat AF as early as possible...
October 13, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/29025889/characterisation-of-asthma-subgroups-associated-with-circulating-ykl-40-levels
#2
Jose L Gomez, Xiting Yan, Carole T Holm, Nicole Grant, Qing Liu, Lauren Cohn, Vera Nezgovorova, Deborah A Meyers, Eugene R Bleecker, Gina M Crisafi, Nizar N Jarjour, Linda Rogers, Joan Reibman, Geoffrey L Chupp
The chitinase-like protein YKL-40 mediates airway inflammation and serum levels are associated with asthma severity. However, asthma phenotypes associated with YKL-40 levels have not been precisely defined.We conducted an unsupervised cluster analysis of asthma patients treated at the Yale Center for Asthma and Airways Disease (n=156) to identify subgroups according to YKL-40 level. The resulting YKL-40 clusters were cross-validated in cohorts from the Severe Asthma Research Programme (n=167) and the New York University/Bellevue Asthma Repository (n=341)...
October 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29025819/time-in-therapeutic-range-warfarin-anticoagulation-for-atrial-fibrillation-in-a-community-based-practice
#3
Derek Gateman, Melissa Elizabeth Trojnar, Gina Agarwal
OBJECTIVE: To evaluate the effectiveness of an outpatient, nurse-administered warfarin anticoagulation protocol for the treatment of atrial fibrillation, and to identify clinical or biographical data that predict poor international normalized ratio control. DESIGN: Retrospective cohort study. SETTING: St Paul Family Health Network in Brantford, Ont. PARTICIPANTS: A total of 150 patients with nonvalvular atrial fibrillation...
October 2017: Canadian Family Physician Médecin de Famille Canadien
https://www.readbyqxmd.com/read/29025136/predictors-of-responsivity-to-interdisciplinary-pain-management
#4
Melissa A Day, Melissa Brinums, Nathan Craig, Laurence Geffen, Saul Geffen, Miriam Lovai, Gina Geffen
Objective: This study investigated for whom interdisciplinary pain management (IPM) is most effective. Identification of predictors of treatment responsivity would facilitate development of patient-treatment matching algorithms to optimize outcomes. Design: Repeated measures prospective study of consecutive admissions to a two-week IPM program. Setting: Brisbane Pain Rehabilitation Service in Brisbane, Australia. Subjects: A total of 163 adults referred for chronic pain management...
July 25, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29024622/smoking-cessation-efforts-by-u-s-adult-smokers-with-medical-comorbidities
#5
Sara Kalkhoran, Gina R Kruse, Yuchiao Chang, Nancy A Rigotti
BACKGROUND: Continued cigarette smoking by individuals with chronic medical diseases can adversely impact their symptoms, disease progression, and mortality. We assessed the association between medical comorbidities and smoking cessation efforts among U.S. adult smokers. METHODS: We analyzed cross-sectional data from 12,494 past-year cigarette smokers age ≥18 years from Wave 1 (2013-2014) of the nationally-representative Population Assessment of Tobacco and Health Study...
October 9, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29023191/use-of-nasogastric-feeding-tubes-for-children-at-home-a-template-for-caregiver-education
#6
Beth Lyman, Gina Rempel, Kerrin Windsor, Peggi Guenter
There is a lack of knowledge on the part of caregivers who need to place nasogastric (NG) tubes in children for enteral nutrition therapy. This article provides the rationale, best practices, and a template for caregiver education. Canadian and Australian programs have excellent patient education materials. They have shared these step-by-step procedures for healthcare professionals to provide to caregivers to whom they are teaching placement and care of NG tubes.
October 1, 2017: Nutrition in Clinical Practice
https://www.readbyqxmd.com/read/29021235/oral-analgesics-utilization-for-children-with-musculoskeletal-injury-ouch-trial-an-rct
#7
Sylvie Le May, Samina Ali, Amy C Plint, Benoit Mâsse, Gina Neto, Marie-Christine Auclair, Amy L Drendel, Ariane Ballard, Christelle Khadra, Edith Villeneuve, Stefan Parent, Patrick J McGrath, Grégoire Leclair, Serge Gouin
BACKGROUND: Musculoskeletal injuries (MSK-Is) are a common and painful condition among children that remains poorly treated in the emergency department (ED). We aimed to test the efficacy of a combination of an anti-inflammatory drug with an opioid for pain management of MSK-I in children presenting to the ED. METHODS: In this randomized, double-blinded, placebo-controlled trial, we enrolled children between 6 and 17 years presenting to the ED with an MSK-I and a pain score >29 mm on the visual analog scale (VAS)...
October 11, 2017: Pediatrics
https://www.readbyqxmd.com/read/29020384/fibrosis-as-measured-by-the-biomarker-tissue-inhibitor-metalloproteinase-1-predicts-mortality-in-age-gene-environment-susceptibility-reykjavik-ages-reykjavik-study
#8
Gina LaRocca, Thor Aspelund, Anders M Greve, Gudny Eiriksdottir, Tushar Acharya, Gudmundur Thorgeirsson, Tamara B Harris, Lenore J Launer, Vilmundur Gudnason, Andrew E Arai
Background: Fibrosis is a key pathological process in many chronic inflammatory disease states. Aims: We hypothesized that tissue inhibitor metalloproteinase-1 and matrix metalloproteinase-9 (TIMP-1 and MMP-9), biomarkers of fibrosis, would predict all-cause mortality and we assessed the incremental value of these biomarkers when adjusting for clinical and other biomarkers. Methods: The cohort included 5511 community-dwelling participants in the AGES-Reykjavik Study...
August 29, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29020340/relationship-between-viremia-and-specific-organ-damage-in-ebola-patients-a-cohort-study
#9
Simone Lanini, Gina Portella, Francesco Vairo, Gary P Kobinger, Antonio Pesenti, Martin Langer, Soccoh Kabia, Giorgio Brogiato, Jackson Amone, Concetta Castilletti, Rossella Miccio, Maria Rosaria Capobianchi, Gino Strada, Alimuddin Zumla, Antonino Di Caro, Giuseppe Ippolito
Background: Pathogenesis of Ebola virus disease remains poorly understood. We used concomitant determination of routine laboratory biomarkers and Ebola viremia to explore the potential role of viral replication in specific organ damage. Methods: We recruited patients with detectable Ebola viremia admitted to the EMERGENCY ONG ONLUS Ebola Treatment Center in Sierra Leone. Repeated measure of Ebola viremia, ALT, AST, bilirubin, CPK, LDH, aPTT, INR, creatinine and BUN were recorded...
August 20, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29020206/concordance-with-prevention-guidelines-and-subsequent-cancer-cardiovascular-disease-and-mortality-a-longitudinal-study-of-older-adults
#10
Heather Greenlee, Garrett Strizich, Gina S Lovasi, Robert C Kaplan, Mary L Biggs, Christopher I Li, John Richardson, Gregory L Burke, Annette L Fitzpatrick, Amanda M Fretts, Bruce M Psaty, Linda P Fried
Reports on the association between multiple clinical and behavioral health indicators and major health outcomes among older adults are scarce. We prospectively examined concordance with American Cancer Society and American Heart Association disease prevention guidelines in relation to cancer, cardiovascular disease (CVD) and mortality among Cardiovascular Health Study enrollees age 65-98 years who at baseline assessment in 1989-1996 (n = 3,491) were free of CVD and cancer. Total and cause-specific mortality, as well as incidence of cancer and CVD, were lower with increased guideline concordance...
August 17, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/28994298/human-aortic-endothelial-cells-respond-to-shear-flow-in-well-plate-microfluidic-devices
#11
Om Makwana, Hannah Flockton, Gary P Watters, Rizwan Nisar, Gina A Smith, Wanda Fields, Betsy Bombick
Although chronic progressive cardiovascular diseases such as atherosclerosis are often challenging to fully model in vitro, it has been shown that certain in vitro methods can effectively evaluate some aspects of disease progression. This has been demonstrated in in vitro and in vivo studies of endothelial cells that have illustrated the effects of nitric oxide (NO) production, filamentous actin (F-actin) formation, and cell and actin angle alignment on vascular function and homeostasis. Systems utilising shear flow have been established, in order to create a physiologically relevant environment for cells that require shear flow for homeostasis...
September 2017: Alternatives to Laboratory Animals: ATLA
https://www.readbyqxmd.com/read/28994035/survivorchess-to-increase-physical-activity-in-colon-cancer-survivors-can-we-get-them-moving
#12
Deborah K Mayer, Gina Landucci, Lola Awoyinka, Amy K Atwood, Cindy L Carmack, Wendy Demark-Wahnefried, Fiona McTavish, David H Gustafson
PURPOSE: This randomized controlled trial evaluated the impact of SurvivorCHESS, an eHealth intervention, on physical activity in colon cancer survivors and to explore the impact of SurvivorCHESS on quality of life and distress. METHODS: This was a two-arm single-blinded multi-site randomized controlled trial comparing a control group to an intervention group receiving a smartphone with the SurvivorCHESS program. RESULTS: Participants using SurvivorCHESS (n = 144) increased their moderate to vigorous physical activities from 19...
October 9, 2017: Journal of Cancer Survivorship: Research and Practice
https://www.readbyqxmd.com/read/28993944/palliative-care-content-on-cancer-center-websites
#13
Laura B Vater, Gina Rebesco, Yael Schenker, Alexia M Torke, Gregory Gramelspacher
PURPOSE: Professional guidelines recommend that palliative care begin early in advanced cancer management, yet integration of palliative and cancer care remains suboptimal. Cancer centers may miss opportunities to provide palliative care information online. In this study, we described the palliative care content on cancer center websites. METHODS: We conducted a systematic content analysis of 62 National Cancer Institute- (NCI) designated cancer center websites...
October 9, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28993934/successful-nuclear-dna-profiling-of-rootless-hair-shafts-a-novel-approach
#14
Kelly S Grisedale, Gina M Murphy, Hiromi Brown, Mark R Wilson, Sudhir K Sinha
Historically, rootless hair shaft samples submitted to a forensic laboratory for DNA analysis are reserved for mitochondrial DNA (mtDNA) analysis due to the presence of highly degraded as well as insufficient amounts of nuclear DNA. Although mtDNA has been very successful in obtaining results from rootless hair, this system has its limitations, namely, it is a lineage marker that cannot differentiate between maternally related genotypes. Given the high incidence of hairs as forensic evidence, there is a need for the use of a nuclear DNA test system capable of producing reliable results for hair shaft forensic evidence...
October 9, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28992737/asenapine-iloperidone-and-lurasidone-exposures-in-young-children-reported-to-u-s-poison-centers
#15
Gina Stassinos, Wendy Klein-Schwartz
CONTEXT: Asenapine, iloperidone and lurasidone are relatively new atypical antipsychotics. There is limited information on toxicity on pediatric exposures to these drugs. The objective of this study was to compare toxicity associated with asenapine, iloperidone and lurasidone exposures in young children. METHODS: A retrospective study of U.S. National Poison Data System from 2010 to 2015 of single substance exposures to asenapine, iloperidone or lurasidone in children <6 years of age that were followed to known outcome was performed...
October 10, 2017: Clinical Toxicology
https://www.readbyqxmd.com/read/28991435/a-space-confined-earth-abundant-bifunctional-electrocatalyst-for-high-efficiency-water-splitting
#16
Yanqun Tang, Xiaoyu Fang, Xin Zhang, Gina Fernandes, Yong Yan, Dongpeng Yan, Xu Xiang, Jing He
Hydrogen generation from water splitting could be an alternative way to meet increasing energy demands while also balancing the impacts of energy being supplied by fossil fuels. The efficacy of water splitting is strongly dependent on the performance of electrocatalysts. Herein, we report a unique space-confined earth abundant bifunctional electrocatalyst for both the hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) leading to high-efficiency water splitting. Outperforming Pt/C or RuO2 catalysts, this mesoscopic, space-confined, bifunctional configuration is constructed from a monolithic zeolitic imidazolate framework@layered double hydroxides (ZIF@LDH) precursor on Ni foam...
October 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28990121/climatic-water-deficit-and-surplus-between-the-carpathian-mountains-and-the-dniester-river-1961-2012
#17
Dumitru Mihăilă, Petruț-Ionel Bistricean, Liliana Gina Lazurca, Andrei-Emil Briciu
The study addresses the climatic water deficit (WD) and surplus (WE) in the area located between the heights of the Eastern Carpathians (Romania) and the Dniester River (Moldova). The objective of this study is to discover the trend of WD/WE (past and future) and its variation in space. WD and WE were calculated as the difference between the amounts of precipitation (P) and the reference evapotranspiration (ET0). The P-ET0 trend, analyzed through Mann-Kendall and t tests, was negative for 83 and 80% of the analyzed stations and the Sen's slope had values between - 0...
October 8, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28987203/informing-intervention-strategies-to-reduce-energy-drink-consumption-in-young-people-findings-from-qualitative-research
#18
Jacinta Francis, Karen Martin, Beth Costa, Hayley Christian, Simmi Kaur, Amelia Harray, Ann Barblett, Wendy Hazel Oddy, Gina Ambrosini, Karina Allen, Gina Trapp
OBJECTIVE: To determine young people's knowledge of energy drinks (EDs), factors influencing ED consumption, and intervention strategies to decrease ED consumption in young people. DESIGN: Eight group interviews with young people (aged 12-25 years). SETTING: Community groups and secondary schools in Perth, Western Australia. PARTICIPANTS: Forty-one young people, 41% of whom were male and 73% of whom consumed EDs. PHENOMENON OF INTEREST: Factors influencing ED consumption and intervention strategies informed by young people to reduce ED consumption...
October 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28986550/pterostilbene-a-natural-phenolic-compound-synergizes-the-antineoplastic-effects-of-megestrol-acetate-in-endometrial-cancer
#19
Wei Wen, Gina Lowe, Cai M Roberts, James Finlay, Ernest S Han, Carlotta A Glackin, Thanh H Dellinger
Endometrial cancer is the most common gynecologic cancer in the United States and its incidence and mortality has been rising over the past decade. Few treatment options are available for patients with advanced and recurring endometrial cancers. Novel therapies, which are frequently toxic, are difficult to establish in this patient population which tends to be older and plagued by comorbidities such as diabetes mellitus and hypertension. Therefore, novel, non-toxic therapies are urgently needed. Megestrol acetate is a frequently used drug in endometrial cancer patients...
October 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28986525/non-invasive-assessment-of-hepatic-mitochondrial-metabolism-by-positional-isotopomer-nmr-tracer-analysis-pinta
#20
Rachel J Perry, Liang Peng, Gary W Cline, Gina M Butrico, Yongliang Wang, Xian-Man Zhang, Douglas L Rothman, Kitt Falk Petersen, Gerald I Shulman
Hepatic mitochondria play a central role in the regulation of intermediary metabolism and maintenance of normoglycemia, and there is great interest in assessing rates of hepatic mitochondrial citrate synthase flux (V CS) and pyruvate carboxylase flux (V PC) in vivo. Here, we show that a positional isotopomer NMR tracer analysis (PINTA) method can be used to non-invasively assess rates of V CS and V PC fluxes using a combined NMR/gas chromatography-mass spectrometry analysis of plasma following infusion of [3-(13)C]lactate and glucose tracer...
October 6, 2017: Nature Communications
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