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https://www.readbyqxmd.com/read/29667338/variation-in-the-tek-gene-is-not-associated-with-asthma-but-with-allergic-conjunctivitis
#1
L E Fodor, A Gézsi, Z Gál, A Nagy, A Kiss, A Bikov, C Szalai
The Tie2 receptor is an important player in angiogenesis. The Tie2 mRNA and protein are abundantly expressed in the lungs and the associated pathway also has an important role in the development and function of the eye. Tie2 is encoded by the TEK gene in humans. Recently, variations in the TEK gene have been found associated with asthma. The objective of the present study was to investigate whether variations in the TEK gene influenced the susceptibility to pediatric asthma and/or associated phenotypes like GINA status, viral- or exercise-induced asthma, allergic asthma, indoor, outdoor, inhalative allergies, IgE and eosonophil levels, allergic rhinitis and allergic conjunctivitis...
April 18, 2018: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29664197/impact-of-systemic-antimicrobial-therapy-on-mucosal-staphylococci-in-a-population-of-dogs-in-northwest-england
#2
Vanessa M Schmidt, Gina Pinchbeck, Tim Nuttall, Steve Shaw, K Marie McIntyre, Neil McEwan, Susan Dawson, Nicola J Williams
BACKGROUND: Antimicrobial-resistant bacteria are increasingly isolated from veterinary patients. OBJECTIVES: To determine risk factors for antimicrobial resistance (AMR) among canine mucosal staphylococci following routine antimicrobial treatment with cefalexin (CFX), clavulanate-amoxicillin (AC), cefovecin (CVN), clindamycin (CD) or a fluoroquinolone (FQ). ANIMALS: Mucosal swab samples (n = 463) were collected from 127 dogs pre-treatment, immediately, and at one- and three-months post-treatment...
April 17, 2018: Veterinary Dermatology
https://www.readbyqxmd.com/read/29663825/clustering-analysis-in-asthmatic-outpatients-an-experience-in-clinical-practice
#3
Giorgio Ciprandi, Michela Silvestri, Angela Pistorio, Fabio Luigi Massimo Ricciardolo
The present real-life study collected medical data from 186 asthmatics with a median age of 40 years. It gathered information on the asthma onset age, allergic rhinitis, comorbidities, smoking, BMI, and severity of respiratory symptoms. Afterwards, ascending hierarchical clustering analysis was performed and outcomes allowed to characterize three different asthma phenotypes. Interestingly, in clustering of asthma patients the most important factor was GINA asthma control scoring corresponding to the asthma control GINA grading...
April 17, 2018: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/29663554/implant-associated-bacterial-biofilm-and-quorum-sensing-in-periprosthetic-joint-infections
#4
Jake A Mooney, Eric M Pridgen, Robert Manasherob, Gina Suh, Helen E Blackwell, Annelise E Barron, Paul L Bollyky, Stuart B Goodman, Derek F Amanatullah
Periprosthetic joint infection (PJI) continues to be a common complication after total knee arthroplasty and total hip arthroplasty leading to severe morbidity and mortality. With an aging population and increasing prevalence of total joint replacement procedures, the burden of PJI will be felt not only by individual patients, but in increased healthcare costs. Current treatment of PJI is inadequate resulting in incredibly high failure rates. This is believed to be largely mediated by the presence of bacterial biofilms...
April 16, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29663325/a-new-approach-to-the-treatment-of-acute-myeloid-leukaemia-targeting-the-receptor-for-growth-hormone-releasing-hormone
#5
Joaquin J Jimenez, Gina M DelCanto, Petra Popovics, Aymee Perez, Ailin Vila Granda, Irving Vidaurre, Ren-Zhi Cai, Ferenc G Rick, Ronan T Swords, Andrew V Schally
Growth hormone-releasing hormone (GHRH) is secreted by the hypothalamus and acts on the pituitary gland to stimulate the release of growth hormone (GH). GHRH can also be produced by human cancers, in which it functions as an autocrine/paracrine growth factor. We have previously shown that synthetic antagonistic analogues of GHRH are able to successfully suppress the growth of 60 different human cancer cell lines representing over 20 cancers. Nevertheless, the expression of GHRH and its receptors in leukaemias has never been examined...
April 16, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29661136/effects-of-a-community-health-promotion-program-on-social-factors-in-a-vulnerable-older-adult-population-residing-in-social-housing
#6
Gina Agarwal, Madison Brydges
BACKGROUND: Supporting older adults' health and wellbeing in the community is an important policy goal that can be supported by health promotion. Despite widespread acceptance of the biopsychosocial model of health and its relation to health, many health promotion programs fail to realize this model in program design. Further, there is limited evidence to support program design targeting social determinants of health such as social isolation or connectedness. To fill this gap, we aimed to understand older adult's experiences participating in cardiovascular health promotion program in a subsidized residential building to capture unintended 'spin-off' psychosocial effects...
April 16, 2018: BMC Geriatrics
https://www.readbyqxmd.com/read/29657324/recent-advances-in-cancer-metabolism-a-technological-perspective
#7
REVIEW
Yun Pyo Kang, Nathan P Ward, Gina M DeNicola
Cancer cells are highly dependent on metabolic pathways to sustain both their proliferation and adaption to harsh microenvironments. Thus, understanding the metabolic reprogramming that occurs in tumors can provide critical insights for the development of therapies targeting metabolism. In this review, we will discuss recent advancements in metabolomics and other multidisciplinary techniques that have led to the discovery of novel metabolic pathways and mechanisms in diverse cancer types.
April 16, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29656911/healthcare-empowerment-and-hiv-viral-control-mediating-roles-of-adherence-and-retention-in-care
#8
Tracey E Wilson, Emma Sophia Kay, Bulent Turan, Mallory O Johnson, Mirjam-Colette Kempf, Janet M Turan, Mardge H Cohen, Adaora A Adimora, Margaret Pereyra, Elizabeth T Golub, Lakshmi Goparaju, Lynn Murchison, Gina M Wingood, Lisa R Metsch
INTRODUCTION: This study assessed longitudinal relationships between patient healthcare empowerment, engagement in care, and viral control in the Women's Interagency HIV Study, a prospective cohort study of U.S. women living with HIV. METHODS: From April 2014 to March 2016, four consecutive 6-month visits were analyzed among 973 women to assess the impact of Time 1 healthcare empowerment variables (Tolerance for Uncertainty and the state of Informed Collaboration Committed Engagement) on Time 2 reports of ≥95% HIV medication adherence and not missing an HIV primary care appointment since last visit; and on HIV RNA viral control across Times 3 and 4, controlling for illicit drug use, heavy drinking, depression symptoms, age, and income...
April 12, 2018: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/29656781/observational-and-genetic-associations-of-resting-heart-rate-with-aortic-valve-calcium
#9
Seamus P Whelton, Andreas C Mauer, Karol M Pencina, Joseph M Massaro, Ralph B D'Agostino, Caroline S Fox, Udo Hoffmann, Erin D Michos, Gina M Peloso, Line Dufresne, James C Engert, Sekar Kathiresan, Matthew Budoff, Wendy S Post, George Thanassoulis, Christopher J O'Donnell
It is unknown if lifelong exposure to increased hemodynamic stress from an elevated resting heart rate (HR) may contribute to aortic valve calcium (AVC). We performed multivariate regression analyses using data from 1,266 Framingham Heart Study (FHS) Offspring cohort participants and 6,764 Multi-Ethnic Study of Atherosclerosis (MESA) participants. We constructed a genetic risk score (GRS) for HR using summary-level data in the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) AVC Consortium to investigate if there was evidence in favor of a causal relation...
February 13, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29656344/orthotidal-signal-in-the-electrical-conductivity-of-an-inland-river
#10
Andrei-Emil Briciu, Dumitru Mihăilă, Dinu Iulian Oprea, Petruț-Ionel Bistricean, Liliana Gina Lazurca
An orthotidal signal is a tidal component found in a streamwater parameter when there is no oceanic tidal input, i.e. when the streamwater monitoring point is located far inland and at high elevation. This study analyses various parameters of Cib River in Carpathian Mountains, Romania. This river receives water from a rich karst aquifer when crossing Cib Gorge. Streamwater level, temperature and electrical conductivity were measured in 270 days grouped in three time intervals of consecutive days. The measurements were done every 15 minutes in order to capture any significant periodic variation...
April 15, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29656008/identification-of-mirnas-linked-with-the-drought-response-of-tef-eragrostis-tef-zucc-trotter
#11
Federico Martinelli, Gina Cannarozzi, Bipin Balan, Fredy Siegrist, Annett Weichert, Regula Blösch, Zerihun Tadele
Tef [Eragrostis tef (Zucc.) Trotter], a staple food crop in the Horn of Africa and particularly in Ethiopia, has several beneficial agronomical and nutritional properties, including waterlogging and drought tolerance. In this study, we performed microRNA profiling of tef using the Illumina HiSeq 2500 platform, analyzing both shoots and roots of two tef genotypes, one drought-tolerant (Tsedey) and one drought-susceptible (Alba). We obtained more than 10 million filtered reads for each of the 24 sequenced small cDNA libraries...
March 29, 2018: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29652828/can-a-simple-dietary-index-derived-from-a-sub-set-of-questionnaire-items-assess-diet-quality-in-a-sample-of-australian-adults
#12
Alexia Bivoltsis, Georgina S A Trapp, Matthew Knuiman, Paula Hooper, Gina L Ambrosini
Large, longitudinal surveys often lack consistent dietary data, limiting the use of existing tools and methods that are available to measure diet quality. This study describes a method that was used to develop a simple index for ranking individuals according to their diet quality in a longitudinal study. The RESIDential Environments (RESIDE) project (2004-2011) collected dietary data in varying detail, across four time points. The most detailed dietary data were collected using a 24-item questionnaire at the final time point ( n = 555; age ≥ 25 years)...
April 13, 2018: Nutrients
https://www.readbyqxmd.com/read/29651696/diversity-of-the-midstream-urine-microbiome-in-adults-with-chronic-kidney-disease
#13
Holly Kramer, Gina Kuffel, Krystal Thomas-White, Alan J Wolfe, Kavitha Vellanki, David J Leehey, Vinod K Bansal, Linda Brubaker, Robert Flanigan, Julia Koval, Anuradha Wadhwa, Michael J Zilliox
PURPOSE: To examine the characteristics of the midstream urine microbiome in adults with stage 3-5 non-dialysis-dependent chronic kidney disease (CKD). METHODS: Patients with non-dialysis-dependent CKD (estimated glomerular filtration rate [eGFR] < 60 ml/min/1.73 m2 ) and diuretic use were recruited from outpatient nephrology clinics. Midstream voided urine specimens were collected using the clean-catch method. The bacterial composition was determined by sequencing the hypervariable (V4) region of the bacterial 16S ribosomal RNA gene...
April 12, 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29650110/targets-for-glycemic-control
#14
S Ali Imran, Gina Agarwal, Harpreet S Bajaj, Stuart Ross
No abstract text is available yet for this article.
April 2018: Canadian Journal of Diabetes
https://www.readbyqxmd.com/read/29649334/urinary-cgmp-predicts-major-adverse-renal-events-in-patients-with-mild-renal-impairment-and-or-diabetes-mellitus-before-exposure-to-contrast-medium
#15
Lyubov Chaykovska, Fabian Heunisch, Gina von Einem, Carl-Friedrich Hocher, Oleg Tsuprykov, Mira Pavkovic, Peter Sandner, Axel Kretschmer, Chang Chu, Saban Elitok, Johannes-Peter Stasch, Berthold Hocher
BACKGROUND: The use of iodine-based contrast agents entails the risk of contrast induced nephropathy (CIN). Radiocontrast agents elicit the third most common cause of nephropathy among hospitalized patients, accounting for 11-12% of cases. CIN is connected with clinically significant consequences, including increased morbidity, prolonged hospitalization, increased risk of complications, potential need for dialysis, and increased mortality rate. The number of in-hospital examinations using iodine-based contrast media has been significantly increasing over the last decade...
2018: PloS One
https://www.readbyqxmd.com/read/29649035/pharmacological-characterization-of-levorphanol-a-g-protein-biased-opioid-analgesic
#16
Valerie Le Rouzic, Ankita Narayan, Amanda Hunkle, Gina F Marrone, Zhigang Lu, Susruta Majumdar, Jin Xu, Ying-Xian Pan, Gavril W Pasternak
BACKGROUND: Levorphanol is a potent analgesic that has been used for decades. Most commonly used for acute and cancer pain, it also is effective against neuropathic pain. The recent appreciation of the importance of functional bias and the uncovering of multiple µ opioid receptor splice variants may help explain the variability of patient responses to different opioid drugs. METHODS: Here, we evaluate levorphanol in a variety of traditional in vitro receptor binding and functional assays...
April 11, 2018: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/29649002/jak1-2-inhibition-with-baricitinib-in-the-treatment-of-autoinflammatory-interferonopathies
#17
Gina A Montealegre Sanchez, Adam Reinhardt, Suzanne Ramsey, Helmut Wittkowski, Philip J Hashkes, Yackov Berkun, Susanne Schalm, Sara Murias, Jason A Dare, Diane Brown, Deborah L Stone, Ling Gao, Thomas Klausmeier, Dirk Foell, Adriana A de Jesus, Dawn C Chapelle, Hanna Kim, Samantha Dill, Robert Colbert, Laura Failla, Bahar Kost, Michelle O'Brien, James C Reynolds, Les R Folio, Katherine R Calvo, Scott M Paul, Nargues Weir, Alessandra Brofferio, Ariane Soldatos, Angélique Biancotto, Edward W Cowen, John G Digiovanna, Massimo Gadina, Andrew J Lipton, Colleen Hadigan, Steven M Holland, Joseph Fontana, Ahmad S Alawad, Rebecca J Brown, Kristina I Rother, Theo Heller, Kristina M Brooks, Parag Kumar, Stephen R Brooks, Meryl Waldman, Harsharan K Singh, Volker Nickeleit, Maria Silk, Apurva Prakash, Jonathan M Janes, Seza Ozen, Paul G Wakim, Paul A Brogan, William L Macias, Raphaela Goldbach-Mansky
BACKGROUND: Monogenic Interferon (IFN)-mediated autoinflammatory diseases present in infancy with systemic inflammation, an IFN-response-gene-signature (IRS), inflammatory organ damage and high mortality. We used the janus kinase (JAK) inhibitor baricitinib with IFN-blocking activity in vitro, to ameliorate disease. METHODS: Between October 2011 and February 2017, 10 patients with CANDLE (chronic atypical neutrophilic dermatosis with lipodystrophy and elevated temperatures), 4 with SAVI (Stimulator of IFN genes (STING)-associated vasculopathy with onset in infancy), and 4 patients with other interferonopathies were enrolled in an Expanded Access Program...
April 12, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29648924/operative-treatment-of-isolated-meniscus-injuries-in-adolescent-patients-a-meta-analysis-and-review
#18
Gina M Mosich, Virginia Lieu, Edward Ebramzadeh, Jennifer J Beck
CONTEXT: With the rise in sports participation and increased athleticism in the adolescent population, there is an ever-growing need to better understand adolescent meniscus pathology and treatment. OBJECTIVE: To better understand the operative management of meniscus tears in the adolescent population. DATA SOURCES: A systematic review of PubMed (MEDLINE) and Google Scholar was performed for all archived years. STUDY SELECTION: Studies that reported on isolated meniscus tears in adolescent patients (age, 10-19 years) were included...
April 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29642759/cannabis-use-and-knowledge-among-medical-students-at-the-university-of-the-free-state-bloemfontein-south-africa
#19
Roshini Jain, Ch Chiech Chang, Mpho A Koto, Alden N Geldenhuys, Richard J Nichol, Gina Joubert
OBJECTIVE: The study aimed to investigate the prevalence of cannabis use among undergraduate medical students of the University of the Free State (UFS), and the extent of their knowledge about the substance. METHOD: This cross-sectional study included five year groups of undergraduate medical students. A self-administered, anonymous questionnaire was used. RESULTS: Of the 643 medical students, 541 (84.1%) completed the questionnaire. In total, 161 (30...
April 11, 2018: Journal of Child and Adolescent Mental Health
https://www.readbyqxmd.com/read/29642744/evaluation-of-continuous-infusion-vancomycin-administration-in-a-critically-ill-trauma-population
#20
Brittany D Bissell, Gina Riggi, Christopher Morrison
Vancomycin is a first-line antibiotic for empiric treatment of gram-positive infections in the trauma intensive care unit. When dosed intermittently, difficulties arise from trough collection and drug monitoring. The objective of this study was to evaluate time to goal vancomycin levels comparing a continuous infusion protocol when compared to standard intermittent infusion dosing. This was a retrospective cohort of patients admitted to the trauma intensive care unit between July 2011 and July 2015 receiving vancomycin for at least 48 hours...
January 1, 2018: Journal of Intensive Care Medicine
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