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Obesity and surgery

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https://www.readbyqxmd.com/read/29331535/estrogen-deprivation-aggravates-cardiometabolic-dysfunction-in-obese-insulin-resistant-rats-through-the-impairment-of-cardiac-mitochondrial-dynamics
#1
Wanitchaya Minta, Siripong Palee, Duangkamol Mantor, Wissuta Sutham, Thidarat Jaiwongkum, Sasiwan Kerdpoo, Wasana Pratchayasakul, Sirinart Kumfu, Siriporn C Chattipakorn, Nipon Chattipakorn
The incidence of cardiovascular disease and metabolic syndrome increases after the onset of menopause, suggesting estrogen has a vital role in their prevention. Mitochondrial dynamics are known to play an important role in the maintenance of cardiac physiological function. However, the effects of estrogen deprivation on cardiometabolic status and cardiac mitochondrial dynamics under conditions of obese-insulin resistance have never been investigated. We hypothesized that estrogen deprivation aggravates cardiac dysfunction through increased cardiac mitochondrial fission in obese-insulin resistant rats...
January 10, 2018: Experimental Gerontology
https://www.readbyqxmd.com/read/29330917/mitochondrial-respiratory-capacity-remains-stable-despite-a-comprehensive-and-sustained-increase-in-insulin-sensitivity-in-obese-patients-undergoing-gastric-bypass-surgery
#2
Michael T Lund, Steen Larsen, Merethe Hansen, Julie Courraud, Andrea K Floyd, Mikael Støckel, Jørn W Helge, Flemming Dela
AIM: It has been proposed, but not yet demonstrated by convincing evidence in published articles, that insulin resistance and mitochondrial respiratory function are causally-related physiological phenomena. Here, we tested the prediction that weight loss induced increase in insulin sensitivity will correlate with a corresponding change in mitochondrial respiratory capacity over the same time period. METHODS: Insulin sensitivity was evaluated using the hyperinsulinaemic-euglycemic clamp technique and skeletal muscle mitochondrial respiratory capacity was evaluated by high-resolution respirometry in 26 patients with obesity...
January 13, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29330678/-quality-indicators-with-reference-values-and-threshold-limits-in-general-and-visceral-surgery-for-obesity-and-metabolic-pancreatic-colon-carcinoma-and-rectal-carcinoma-surgery
#3
EDITORIAL
H J Buhr, J Hardt, C Klinger, F Seyfried, A Wiegering, A Dietrich, D K Bartsch, D Lorenz, S Post, C T Germer, T Keck, U Wellner
No abstract text is available yet for this article.
January 2018: Der Chirurg; Zeitschrift Für Alle Gebiete der Operativen Medizen
https://www.readbyqxmd.com/read/29330654/risk-prediction-model-for-severe-postoperative-complication-in-bariatric-surgery
#4
Erik Stenberg, Yang Cao, Eva Szabo, Erik Näslund, Ingmar Näslund, Johan Ottosson
BACKGROUND: Factors associated with risk for adverse outcome are important considerations in the preoperative assessment of patients for bariatric surgery. As yet, prediction models based on preoperative risk factors have not been able to predict adverse outcome sufficiently. OBJECTIVE: This study aimed to identify preoperative risk factors and to construct a risk prediction model based on these. METHODS: Patients who underwent a bariatric surgical procedure in Sweden between 2010 and 2014 were identified from the Scandinavian Obesity Surgery Registry (SOReg)...
January 12, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29329975/risk-of-suicide-and-non-fatal-self-harm-after-bariatric-surgery-results-from-two-matched-cohort-studies
#5
Martin Neovius, Gustaf Bruze, Peter Jacobson, Kajsa Sjöholm, Kari Johansson, Fredrik Granath, Johan Sundström, Ingmar Näslund, Claude Marcus, Johan Ottosson, Markku Peltonen, Lena M S Carlsson
BACKGROUND: Bariatric surgery reduces mortality, but might have adverse effects on mental health. We assessed the risk of suicide and self-harm after bariatric surgery compared with non-surgical obesity treatment. METHODS: Suicide and non-fatal self-harm events retrieved from nationwide Swedish registers were examined in two cohorts. The non-randomised, prospective Swedish Obese Subjects (SOS) study compared bariatric surgery (n=2010; 1369 vertical-banded gastroplasty, 376 gastric banding, and 265 gastric bypass) with usual care (n=2037; recruitment 1987-2001)...
January 9, 2018: Lancet Diabetes & Endocrinology
https://www.readbyqxmd.com/read/29329881/defining-and-mitigating-the-challenges-of-an-older-and-obese-population-in-minimally-invasive-gynecologic-cancer-surgery
#6
Andrea R Hagemann, Carolyn K McCourt, Swarup S Varaday, Kathleen N Moore
The incidence of endometrial cancer (EC) is steadily increasing due in large part to an aging world population and rise in rates of obesity. Patients with obesity and advancing age can be seen as vulnerable populations, as they are both often subject to physician bias regarding surgical choices and assumptions regarding long-term outcomes. As we operate on an older and/or obese patient population, it is increasingly important that we adopt peri-operative management strategies and surgical techniques to best serve this complex patient population...
January 9, 2018: Gynecologic Oncology
https://www.readbyqxmd.com/read/29329689/pediatric-obesity-current-concepts
#7
REVIEW
Donald E Greydanus, Marisha Agana, Manmohan K Kamboj, Saad Shebrain, Neelkamal Soares, Ransome Eke, Dilip R Patel
This discussion reflects on concepts of obesity in children and adolescents in the early 21st century. It includes reflections on its history, definition, epidemiology, diagnostic perspectives, psychosocial considerations, musculoskeletal complications, endocrine complications and principles of management. In addition to emphasis on diet and exercise, research and clinical applications in the second decade of the 21st century emphasize the increasing use of pharmacotherapy and bariatric surgery for adolescent and adult populations with critical problems of overweight and obesity...
January 9, 2018: Disease-a-month: DM
https://www.readbyqxmd.com/read/29327298/the-impact-of-obesity-on-outcomes-for-patients-undergoing-mastectomy-using-the-acs-nsqip-data-set
#8
Mary Garland, Fang-Chi Hsu, Clancy Clark, Akiko Chiba, Marissa Howard-McNatt
PURPOSE: According to the World Health Organization (WHO), 34.7% of females in the United States are obese (BMI ≥ 30) in 2014, compared to 32.5% in 2010. The previous research has demonstrated high BMI as an independent risk factor for surgical complications after breast surgery. As more patients become obese, we sought to examine whether increasing obesity had an effect on outcomes of women who underwent a unilateral mastectomy without breast reconstruction. METHODS: The study reviewed the 2007-2012 ACS-NSQIP database and identified all patients who underwent a unilateral mastectomy without reconstruction...
January 11, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29327184/efficacy-of-forced-air-warming-to-prevent-perioperative-hypothermia-in-morbidly-obese-versus-non-obese-patients
#9
Raphael Okoué, Daniela Calabrese, Pascal Nzé, Simon Msika, Hawa Keita
BACKGROUND: Hypothermia is associated with an increased postoperative morbidity and mortality. Forced-air warming systems are the most effective methods for its prevention. When using a mattress, a reduction in the area of diffusion of warm air by crushing due to excess weight cannot be ruled out. METHODS: We designed a prospective study to compare the efficacy of a forced-air warming mattress (Bair Hugger® 585) to prevent hypothermia (core temperature (CT°) < 36 °C) in morbidly obese (group MO, body mass index (BMI) ≥ 40 kg/m2) and non-obese patients (group NO, BMI < 30 kg/m2)...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29327182/changes-in-iron-absorption-after-roux-en-y-gastric-bypass
#10
Wendy Schijns, Marjolein A P Ligthart, Frits J Berends, Ignace M C Janssen, Cees J H M van Laarhoven, Edo O Aarts, Hans de Boer
INTRODUCTION: Iron deficiency is one of the most common deficiencies that may occur after Roux-en-Y gastric bypass (RYGB). Little is known about the optimal treatment of post-RYGB iron deficiency. AIM: The aim of this study is to evaluate the changes in iron absorption characteristics after RYGB for two oral iron formulations, one presented in tablet form and one as in the form of a solution. METHOD: Iron absorption in 24 obese women was studied before and 1 month after RYGB...
January 11, 2018: Obesity Surgery
https://www.readbyqxmd.com/read/29324643/nutritional-status-of-bariatric-surgery-candidates
#11
Aliaa Al-Mutawa, Alfred Kojo Anderson, Salman Alsabah, Mohammad Al-Mutawa
Obesity is a global epidemic affecting populations globally. Bariatric surgery is an effective treatment for morbid obesity, and has increased dramatically. Bariatric surgery candidates frequently have pre-existing nutritional deficiencies that might exacerbate post-surgery. To provide better health care management pre- and post-bariatric surgery, it is imperative to establish the nutritional status of prospective patients before surgery. The aim of this study was to assess and provide baseline data on the nutritional status of bariatric candidates...
January 11, 2018: Nutrients
https://www.readbyqxmd.com/read/29322584/effects-of-fixation-on-electrophysiology-and-structure-of-human-jejunal-villi
#12
Anna Casselbrant, Herbert F Helander
The villi of human jejunum vary in size and shape during different functional conditions. In the base the lamina propria is isotonic with blood, in the tip hyperosmotic. Here we study electrophysiological and morphological effects of incubation in hypotonic, isotonic, or hypertonic solutions, and to test various isotonic fixatives for microscopy. Samples of jejunal mucosae, obtained during surgery in obese patients, were studied in Ussing chambers where electrical parameters were registered during incubation in Krebs solution at various osmolarities, and during fixation in formaldehyde, glutaraldehyde, or osmium tetroxide (OsO4 )...
January 11, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29321243/adipose-depot-specific-effects-of-ileal-interposition-surgery-in-ucd-t2d-rats-unexpected-implications-for-obesity-and-diabetes
#13
Connie Hung, Casey Bronec, Eleonora Napoli, James Graham, Kimber L Stanhope, Ilaria Marsilio, Maria Cecilia Giron, Peter J Havel, Cecilia Giulivi
Ileal interposition (IT) surgery delays the onset of diabetes in a rat model of type-2 diabetes (UCD-T2DM). Here, to gain a deeper understanding of the molecular events underlying the effects of IT surgery, we examined the changes in the proteome of 4 white adipose depots (retroperitoneal, mesenteric, inguinal, and epididymal), and plasma free fatty acid profile in pre-diabetic rats 1.5 months following IT or sham surgery. The IT-mediated changes were exerted mainly in mesenteric fat, and spanned from delayed adipocyte maturation to a neuroendocrine remodeling...
January 10, 2018: Biochemical Journal
https://www.readbyqxmd.com/read/29319834/nordiska-riktlinjer-f%C3%A3-r-kosttillskott-och-uppf%C3%A3-ljning-efter-obesitaskirurgi-monitorering-och-supplementering-med-vitaminer-och-mineraler
#14
Anna Laurenius, Ingmar Näslund, Jorunn Sandvik, Per Videhult, Mikael Wirén
Each year 6,800 bariatric operations are performed in Sweden. Bariatric surgery involves both a reduced intake and a reduced absorption of vitamins and minerals. There has been debate about whose responsibility long-term follow-up is, particularly regarding monitoring vitamin and mineral status. The Swedish Society for Bariatric Surgery and the Norwegian Association for Bariatric Surgery, who oversee their respective national quality registers, have appointed an expert group to develop guidelines for postoperative supplementation and nutritional monitoring of vitamins and minerals, along with a schedule for routine follow-up...
January 9, 2018: Läkartidningen
https://www.readbyqxmd.com/read/29319659/residual-neurological-symptoms-after-peripheral-nerve-blocks-for-pediatric-knee-surgery
#15
Robert J Tamai, Brian T Sullivan, Rushyuan J Lee
BACKGROUND: Peripheral nerve blocks (PNBs) provide excellent pain control and reduce the need for systemic analgesics in orthopaedic surgery. PNBs rarely cause complications; however, a few studies of adults have reported neurological complications during the early postoperative period. We investigated complications associated with the use of PNBs during pediatric knee surgery. METHODS: We reviewed the medical records of all 121 children (aged ≤18 y) who underwent knee surgery by 1 orthopaedic surgeon between October 2014 and September 2016...
January 9, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29316601/bariatric-surgery-and-infertility-a-prospective-study
#16
Vincenzo Consalvo, Antonio Canero, Vincenzo Salsano
BACKGROUND: Obesity is a worldwide disease affecting 13% of the world's adult female population. The reasons and the fetal risk are still unclear. The effect of weight loss as a result of bariatric surgery seems to induce an improvement in fertility in obese women. The main purpose of this prospective study is to demonstrate if there is an association between bariatric surgery-induced weight loss and an improvement in the fertility of women at reproductive age. MATERIALS AND METHODS: From June 2013 to April 2016, all bariatric female patients from our institutes were prospectively evaluated for suitability in this study...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29316386/changes-in-pain-sensitization-after-bariatric-surgery
#17
Joshua J Stefanik, David T Felson, Caroline M Apovian, Jingbo Niu, M Margaret Clancy, Michael P LaValley, Tuhina Neogi
OBJECTIVE: To evaluate changes in pain (at the knee and elsewhere) and pain sensitization in obese persons with knee pain undergoing bariatric surgery compared with similarly obese persons undergoing medical management. METHODS: Individuals undergoing bariatric surgery and medical management were recruited. Knee pain severity of the more painful knee (index knee) was assessed at baseline and 12 months using the WOMAC. Pressure pain threshold (PPT) was assessed at the index patella and the right wrist...
January 5, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29315584/evaluation-of-extended-antibiotic-prophylaxis-in-patients-undergoing-indicated-non-cosmetic-panniculectomy-at-the-time-of-gynecologic-surgery
#18
Jay R Patibandla, Christina N Kufel, Michael P Hopkins
BACKGROUND: Panniculectomy at time of gynecologic surgery is used to improve visualization and prevent major complications in morbidly obese patients. We examine the role of extended antibiotic prophylaxis in prevention of surgical site infections (SSI), specifically based on patient risk factors (hypertension, diabetes, smoking). METHODS: A prospective cohort study of all women who underwent panniculectomy at the time of gynecologic surgery from September 2014 to March 2016 at a university-affiliated hospital...
January 8, 2018: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29315184/obesity-does-not-increase-operative-time-in-otologic-surgery-an-analysis-of-5125-cases
#19
Thomas Muelleman, Matthew Shew, Robert J Muelleman, Mark Villwock, Kevin Sykes, Hinrich Staecker, James Lin
OBJECTIVES: A large shoulder can impact otologic surgical access. The physical obstruction of a large shoulder may force the surgeon to adjust his or her posture or hand position. We sought to assess the effect of body mass index (BMI) on operative time in tympanoplasties and tympanomastoidectomies. STUDY DESIGN: Cross-sectional analysis. SETTING: National surgical quality improvement program dataset (NSQIP) 2011 to 2014. PATIENTS: Current procedural terminology (CPT) codes were used to identify patients undergoing tympanoplasties and tympanomastoidectomies...
February 2018: Otology & Neurotology
https://www.readbyqxmd.com/read/29315090/incidence-and-risk-factors-for-anastomotic-failure-in-1594-patients-treated-by-transanal-total-mesorectal-excision-results-from-the-international-tatme-registry
#20
Marta Penna, Roel Hompes, Steve Arnold, Greg Wynn, Ralph Austin, Janindra Warusavitarne, Brendan Moran, George B Hanna, Neil J Mortensen, Paris P Tekkis
OBJECTIVE: To determine the incidence of anastomotic-related morbidity following Transanal Total Mesorectal Excision (TaTME) and identify independent risk factors for failure. BACKGROUND: Anastomotic leak and its sequelae are dreaded complications following gastrointestinal surgery. TaTME is a recent technique for rectal resection, which includes novel anastomotic techniques. METHODS: Prospective study of consecutive reconstructed TaTME cases recorded over 30 months in 107 surgical centers across 29 countries...
January 5, 2018: Annals of Surgery
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