Michiaki Kojima, Kanami Machida, Sumie Cho, Daichi Watanabe, Hiroyuki Seki, Miyuki Shimoji, Ayuko Imaoka, Hiroshi Yamazaki, F Peter Guengerich, Katsunori Nakamura, Koujirou Yamamoto, Takeshi Akiyoshi, Hisakazu Ohtani
1. Temperature is considered to affect the activity of drug-metabolizing enzymes; however, no previous studies have compared temperature dependency among cytochrome P450 genetic variants. This study aimed to analyze warfarin 7-hydroxylation by CYP2C9 variants; omeprazole 5-hydroxylation by CYP2C19 variants; and midazolam 1-hydroxylation by CYP3A4 variants at 34 °C, 37 °C, and 40 °C.2. Compared with that seen at 37 °C, the intrinsic clearance rates ( V max / K m ) of CYP2C9...
August 16, 2023: Xenobiotica; the Fate of Foreign Compounds in Biological Systems