keyword
https://read.qxmd.com/read/37108713/in-silico-design-of-a-chimeric-humanized-l-asparaginase
#21
JOURNAL ARTICLE
Alejandro Pedroso, Lisandra Herrera Belén, Jorge F Beltrán, Rodrigo L Castillo, Adalberto Pessoa, Enrique Pedroso, Jorge G Farías
Acute lymphoblastic leukemia (ALL) is the most common cancer among children worldwide, characterized by an overproduction of undifferentiated lymphoblasts in the bone marrow. The treatment of choice for this disease is the enzyme L-asparaginase (ASNase) from bacterial sources. ASNase hydrolyzes circulating L-asparagine in plasma, leading to starvation of leukemic cells. The ASNase formulations of E. coli and E. chrysanthemi present notorious adverse effects, especially the immunogenicity they generate, which undermine both their effectiveness as drugs and patient safety...
April 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36770891/targeting-proliferation-signals-and-the-cell-cycle-machinery-in-acute-leukemias-novel-molecules-on-the-horizon
#22
REVIEW
Andrea Ghelli Luserna di Rorà, Mouna Jandoubi, Giovanni Martinelli, Giorgia Simonetti
Uncontrolled proliferative signals and cell cycle dysregulation due to genomic or functional alterations are important drivers of the expansion of undifferentiated blast cells in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) cells. Therefore, they are largely studied as potential therapeutic targets in the field. We here present the most recent advancements in the evaluation of novel compounds targeting cell cycle proteins or oncogenic mechanisms, including those showing an antiproliferative effect in acute leukemia, independently of the identification of a specific target...
January 26, 2023: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/36261335/acute-undifferentiated-leukemia-limited-to-neck-lymph-nodes-and-a-large-mediastinal-mass
#23
JOURNAL ARTICLE
Kenta Hayashino, Masayuki Matsuda, Keigo Fujishita, Jun Iwata, Miki Mizobuchi, Munenori Uemura, Kenji Yorita, Akiko Maeshima, Toshi Imai
In the 2016 update of the World Health Organization (WHO) classification of myeloid neoplasms, acute undifferentiated leukemia (AUL) was defined by a lack of lineage-specific markers. AUL has very poor prognosis and no established therapies due to its rarity. We report a case of a 31-year-old man with AUL who showed complete molecular response to an acute lymphoblastic leukemia (ALL)-based regimen and received allogeneic hematopoietic stem cell transplantation. The patient's blast cells were CD7-positive and localized to lymph nodes in the neck and to a large mediastinal mass; there was also rearrangement of the T-cell receptor delta locus...
December 28, 2022: Journal of Clinical and Experimental Hematopathology: JCEH
https://read.qxmd.com/read/36232559/genomic-landscape-of-mixed-phenotype-acute-leukemia
#24
JOURNAL ARTICLE
Marah Hennawi, Nagehan Pakasticali, Hammad Tashkandi, Mohammad Hussaini
Mixed-phenotype leukemia (MPAL) is a type of acute leukemia in which the blast population shows mixed features of myeloid, T-lymphoid, and/or B-lymphoid differentiation. MPALs are rare and carry a poor prognosis, thus, often pose both a diagnostic and therapeutic challenge. Conventionally, the diagnosis of MPAL requires either a single blast population with a lineage-defining phenotypic expression of multiple lineages (myeloid, B-cell and/or T-cell) (biphenotypic) or two distinct blast populations that each independently satisfy criteria for designation as AML, B-ALL, and/or T-ALL (bilineage)...
September 24, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36228424/insulin-like-growth-factor-1-regulates-follicle-selection-of-hens-by-promoting-proliferation-and-inhibiting-apoptosis-of-granulosa-cells-in-prehierarchical-follicles-in-vitro
#25
JOURNAL ARTICLE
Mengqi Zhu, Dan Wang, Kexin Zou, Fang Wang, Zechun Zhang, Xinru Song, Cunling Jia, Zehui Wei
During the reproduction stage of poultry, a single follicle is selected from a cohort of 6-8 mm small yellow follicles to initiate rapid growth and final ovulation almost daily. In the process, follicle-stimulating hormone (FSH) plays a pivotal role by interacting with intraovarian factors, including insulin-like growth Factor 1 (IGF1). The objective of this study was to analyze whether IGF1 coordinates with FSH to affect the characteristics of granulosa cells from prehierarchical follicles. After treating granulosa cells with 50 ng/mL FSH and 200 ng/mL IGF1, we detected the proliferation and apoptosis of granulosa cells using flow cytometry...
October 8, 2022: Animal Reproduction Science
https://read.qxmd.com/read/36163769/aml-131-erg-from-a-fortuitous-discovery-to-potential-treatment-for-aml
#26
JOURNAL ARTICLE
Eitan Kugler, Shreyas Madiwale, Darren Yong, Yehudit Birger, Julie Ai Thoms, David B Sykes, Muhammad Yassin, Nasma Aqaqe, Avigail Rein, Hila Fishman, Ifat Geron, Chun-Wei Chen, Brian Raught, Qiao Liu, Michael Milyavsky, John Pimanda, Gilbert G Privé, Shai Izraeli
BACKGROUND: The ETS transcription factor ERG is essential for the maintenance of hematopoietic stem cells. However, it has also been implicated as an oncogene in the development of acute leukemia. Our studies and those of others have demonstrated that ERG directly contributes to the initiation and maintenance of lymphoid and myeloid acute leukemia subtypes. Nevertheless, ERG co-factors critically involved in leukemogenesis remain largely uncharacterized. AIMS: Here we report a critical role for the conserved amino-acid proline at position 199, at the 3' end of the PNT domain, for ERG's leukemogenic activity...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36163734/all-257-detection-of-deletion-in-the-ikzf1-gene-and-the-notch1-signaling-pathway-in-patients-with-t-cell-acute-lymphoblastic-leukemia-data-of-the-rall-study-group
#27
JOURNAL ARTICLE
Anastasia N Vasileva, Olga A Aleshina, Andrey B Sudarikov, Bella V Biderman, Galina A Isinova, Ekaterina S Kotova, Elena N Parovichnikova
BACKGROUND: Mutation in the NOTCH1 is the most frequent event in patients with T-acute lymphoblastic leukemia (ALL). This mutation is associated with a favorable prognosis. Deletion of the IKZF1 gene, occurring in patients with T-ALL in about 10% of cases, is a prognostically unfavorable anomaly. AIM: To evaluate the survival of patients with T-ALL depending on the immunophenotype, as well as to analyze the frequency of occurrence of anomalies in the NOTCH1 and IKZF1 genes...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36070230/amplification-of-runx1-in-a-patient-with-aml
#28
JOURNAL ARTICLE
Rodrigo Hurtado, Stalin Tello, Juan Juarez, Carlos A Tirado
Acute myeloid leukemia (AML) is a heterogeneous disease, characterized by clonal expansion of undifferentiated myeloid precursors, leading to alterations in hematopoiesis and bone marrow failure. Characteristic chromosomal abnormalities in AML are translocations t(8;21), inv(16), t(15;17), t(9;22), as well as mutations of genes that regulate proliferation and survival (FLT 3, PTPN 11, ETV 6/PDGFB), or genes responsible for differentiation and apoptosis (RUNX-1/RUNX1T1, PML/RARA, KMT2A, CEBPA and CBFB). Amplification of RUNX1 is a rare event in AML...
2022: Journal of the Association of Genetic Technologists
https://read.qxmd.com/read/36042201/multi-omics-analysis-defines-highly-refractory-ras-burdened-immature-subgroup-of-infant-acute-lymphoblastic-leukemia
#29
JOURNAL ARTICLE
Tomoya Isobe, Masatoshi Takagi, Aiko Sato-Otsubo, Akira Nishimura, Genta Nagae, Chika Yamagishi, Moe Tamura, Yosuke Tanaka, Shuhei Asada, Reina Takeda, Akiho Tsuchiya, Xiaonan Wang, Kenichi Yoshida, Yasuhito Nannya, Hiroo Ueno, Ryo Akazawa, Itaru Kato, Takashi Mikami, Kentaro Watanabe, Masahiro Sekiguchi, Masafumi Seki, Shunsuke Kimura, Mitsuteru Hiwatari, Motohiro Kato, Shiro Fukuda, Kenji Tatsuno, Shuichi Tsutsumi, Akinori Kanai, Toshiya Inaba, Yusuke Shiozawa, Yuichi Shiraishi, Kenichi Chiba, Hiroko Tanaka, Rishi S Kotecha, Mark N Cruickshank, Fumihiko Ishikawa, Tomohiro Morio, Mariko Eguchi, Takao Deguchi, Nobutaka Kiyokawa, Yuki Arakawa, Katsuyoshi Koh, Yuki Aoki, Takashi Ishihara, Daisuke Tomizawa, Takako Miyamura, Eiichi Ishii, Shuki Mizutani, Nicola K Wilson, Berthold Göttgens, Satoru Miyano, Toshio Kitamura, Susumu Goyama, Akihiko Yokoyama, Hiroyuki Aburatani, Seishi Ogawa, Junko Takita
KMT2A-rearranged infant acute lymphoblastic leukemia (ALL) represents the most refractory type of childhood leukemia. To uncover the molecular heterogeneity of this disease, we perform RNA sequencing, methylation array analysis, whole exome and targeted deep sequencing on 84 infants with KMT2A-rearranged leukemia. Our multi-omics clustering followed by single-sample and single-cell inference of hematopoietic differentiation establishes five robust integrative clusters (ICs) with different master transcription factors, fusion partners and corresponding stages of B-lymphopoietic and early hemato-endothelial development: IRX-type differentiated (IC1), IRX-type undifferentiated (IC2), HOXA-type MLLT1 (IC3), HOXA-type MLLT3 (IC4), and HOXA-type AFF1 (IC5)...
August 30, 2022: Nature Communications
https://read.qxmd.com/read/35990601/hedgehog-gli-signaling-in-hematopoietic-development-and-acute-myeloid-leukemia-from-bench-to-bedside
#30
REVIEW
Suzana Tesanovic, Peter W Krenn, Fritz Aberger
While the underlying genetic alterations and biology of acute myeloid leukemia (AML), an aggressive hematologic malignancy characterized by clonal expansion of undifferentiated myeloid cells, have been gradually unraveled in the last decades, translation into clinical treatment approaches has only just begun. High relapse rates remain a major challenge in AML therapy and are to a large extent attributed to the persistence of treatment-resistant leukemic stem cells (LSCs). The Hedgehog (HH) signaling pathway is crucial for the development and progression of multiple cancer stem cell driven tumors, including AML, and has therefore gained interest as a therapeutic target...
2022: Frontiers in Cell and Developmental Biology
https://read.qxmd.com/read/35857043/does-hand-mirror-morphology-a-useful-diagnostic-tool-for-the-treatment-decision-of-acute-undifferentiated-leukemia-at-admission
#31
JOURNAL ARTICLE
U Atas, S Turgut, T Ulas, U Iltar, O Salim, S B Karauzum, L Undar
It is difficult how to manage acute undifferentiated leukemia in daily practice, but generally, hand mirror morphology provides ease to treat these patients. Thirty-nine years old male patient was admitted to with the complaints of echymosis, and pain at his left buttock due to an intramuscular injection for the treatment of previously diagnosed of the lower respiratory infection. Peripheral blood smear revealed >%50 blasts cells with a moderate nuclear: cytoplasmic ratio and one or more nucleoli. The blast cells showed a hand-mirror morphology and not harboring auer rods...
July 2022: La Clinica Terapeutica
https://read.qxmd.com/read/35775438/how-i-diagnose-acute-leukemia-of-ambiguous-lineage
#32
REVIEW
Olga K Weinberg, Daniel A Arber
OBJECTIVES: Classification of acute leukemia involves assigning lineage by resemblance to normal progenitor cells. This approach provides descriptive information about the blast cells that is useful for disease monitoring, provides clues to pathogenesis, and can help clinicians select effective chemotherapeutic regimens. Acute leukemias of ambiguous lineage (ALALs) are those leukemias that either fail to show evidence of myeloid, B-, or T-lymphoid lineage commitment or show evidence of commitment to more than 1 lineage...
July 1, 2022: American Journal of Clinical Pathology
https://read.qxmd.com/read/35673665/myeloid-sarcoma-of-the-skull-base-a-case-report-and-systematic-literature-review
#33
Prazwal Athukuri, A Basit Khan, Ron Gadot, Monira Haque, Sungho Lee, K Kelly Gallagher, Martha P Mims, Gustavo A Rivero, Andreia Barbieri, Akash J Patel, Ali Jalali
Background: Myeloid sarcoma (MS), or chloroma, is a rare extramedullary malignant tumor that consists of undifferentiated granulocytic cells, and it is most commonly associated with acute myeloid leukemia (AML). Intracranial MS accounts for 0.4% of MS cases, and involvement of the skull base and visual dysfunction is rarely reported. However, the optimal treatment and response to treatment of skull base MS in the presence of visual symptoms is unknown. Case Description: A 30-year-old male with a history of AML presented with rapidly progressive vision loss and a sellar and parasellar mass with bilateral cavernous sinus and optic nerve encasement...
2022: Surgical Neurology International
https://read.qxmd.com/read/35626090/diphenyleneiodonium-triggers-cell-death-of-acute-myeloid-leukemia-cells-by-blocking-the-mitochondrial-respiratory-chain-and-synergizes-with-cytarabine
#34
JOURNAL ARTICLE
Hassan Dakik, Maya El Dor, Jérôme Bourgeais, Farah Kouzi, Olivier Herault, Fabrice Gouilleux, Kazem Zibara, Frédéric Mazurier
Acute myeloid leukemia (AML) is characterized by the accumulation of undifferentiated blast cells in the bone marrow and blood. In most cases of AML, relapse frequently occurs due to resistance to chemotherapy. Compelling research results indicate that drug resistance in cancer cells is highly dependent on the intracellular levels of reactive oxygen species (ROS). Modulating ROS levels is therefore a valuable strategy to overcome the chemotherapy resistance of leukemic cells. In this study, we evaluated the efficiency of diphenyleneiodonium (DPI)-a well-known inhibitor of ROS production-in targeting AML cells...
May 18, 2022: Cancers
https://read.qxmd.com/read/35512442/multiple-cells-of-origin-in-common-with-various-types-of-mouse-n-myc-acute-leukemia
#35
JOURNAL ARTICLE
Haitao Bai, Qingyun Zhang, Sen Zhang, Jinhong Wang, Bingqing Luo, Yan Dong, Jianzhao Gao, Tao Cheng, Fang Dong, Hideo Ema
Little is known regarding whether the cell of origin differs among different leukemia types. To address this fundamental issue, we determined the cell of origin in five distinct types of acute leukemia induced by N-Myc overexpression in mice. CD150+ CD48- CD41- CD34- c-Kit+ Sca-1+ Lin- (KSL) (HSC1) cells, CD150- CD48- CD41- CD34- KSL (HSC2) cells, CD150+ CD41+ CD34- KSL (HPC1) cells, CD150+ CD41+ CD34+ KSL (HPC2) cells, and CD150- CD41- CD34+ KSL (HPC3) cells were purified from the bone marrow of adult C57BL/6 mice, transduced with the N-Myc retrovirus vector, and transplanted into lethally irradiated mice...
June 2022: Leukemia Research
https://read.qxmd.com/read/35476984/hypoxic-glycolytic-metabolism-is-a-vulnerability-of-b-acute-lymphoblastic-leukemia-initiating-cells
#36
JOURNAL ARTICLE
Vivian Morris, Dahai Wang, Zhiheng Li, William Marion, Travis Hughes, Patricia Sousa, Taku Harada, Shannan Ho Sui, Sergey Naumenko, Jérémie Kalfon, Prerana Sensharma, Marcelo Falchetti, Renan Vinicius da Silva, Tito Candelli, Pauline Schneider, Thanasis Margaritis, Frank C P Holstege, Yana Pikman, Marian Harris, Ronald W Stam, Stuart H Orkin, Angela N Koehler, Alex K Shalek, Trista E North, Maxim Pimkin, George Q Daley, Edroaldo Lummertz da Rocha, R Grant Rowe
High-risk forms of B-acute lymphoblastic leukemia (B-ALL) remain a therapeutic challenge. Leukemia-initiating cells (LICs) self-renew and spark relapse and therefore have been the subject of intensive investigation; however, the properties of LICs in high-risk B-ALL are not well understood. Here, we use single-cell transcriptomics and quantitative xenotransplantation to understand LICs in MLL-rearranged (MLL-r) B-ALL. Compared with reported LIC frequencies in acute myeloid leukemia (AML), engraftable LICs in MLL-r B-ALL are abundant...
April 26, 2022: Cell Reports
https://read.qxmd.com/read/35454781/early-t-cell-precursor-all-and-beyond-immature-and-ambiguous-lineage-t-all-subsets
#37
REVIEW
Eulàlia Genescà, Roberta la Starza
A wide range of immature acute leukemias (AL), ranging from acute myeloid leukemias with minimal differentiation to acute leukemias with an ambiguous lineage, i.e., acute undifferentiated leukemias and mixed phenotype acute leukemia with T- or B-plus myeloid markers, cannot be definitely assigned to a single cell lineage. This somewhat "grey zone" of AL expresses partly overlapping features with the most immature forms of T-cell acute lymphoblastic leukemia (T-ALL), i.e., early T-cell precursor ALL (ETP-ALL), near-ETP-ALL, and pro-T ALL...
April 8, 2022: Cancers
https://read.qxmd.com/read/35442720/acute-leukemia-classification-using-transcriptional-profiles-from-low-cost-nanopore-mrna-sequencing
#38
JOURNAL ARTICLE
Jeremy Wang, Nickhill Bhakta, Vanessa Ayer Miller, Mahler Revsine, Mark R Litzow, Elisabeth Paietta, Yuri Fedoriw, Kathryn G Roberts, Zhaohui Gu, Charles G Mullighan, Corbin D Jones, Thomas B Alexander
PURPOSE: Most cases of pediatric acute leukemia occur in low- and middle-income countries, where health centers lack the tools required for accurate diagnosis and disease classification. Recent research shows the robustness of using unbiased short-read RNA sequencing to classify genomic subtypes of acute leukemia. Compared with short-read sequencing, nanopore sequencing has low capital and consumable costs, making it suitable for use in locations with limited health infrastructure. MATERIALS AND METHODS: We show the feasibility of nanopore mRNA sequencing on 134 cryopreserved acute leukemia specimens (26 acute myeloid leukemia [AML], 73 B-lineage acute lymphoblastic leukemia [B-ALL], 34 T-lineage acute lymphoblastic leukemia, and one acute undifferentiated leukemia)...
April 2022: JCO Precision Oncology
https://read.qxmd.com/read/35385564/vcp-inhibition-induces-an-unfolded-protein-response-and-apoptosis-in-human-acute-myeloid-leukemia-cells
#39
JOURNAL ARTICLE
Paweł P Szczęśniak, Jan B Heidelberger, Hubert Serve, Petra Beli, Sebastian A Wagner
Acute myeloid leukemia (AML) is a heterogeneous malignancy characterized by the accumulation of undifferentiated white blood cells (blasts) in the bone marrow. Valosin-containing protein (VCP) is an abundant molecular chaperone that extracts ubiquitylated substrates from protein complexes and cellular compartments prior to their degradation by the proteasome. We found that treatment of AML cell lines with the VCP inhibitor CB-5083 leads to an accumulation of ubiquitylated proteins, activation of unfolded protein response (UPR) and apoptosis...
2022: PloS One
https://read.qxmd.com/read/35356416/expanding-diagnostic-criteria-multiorgan-t-cell-myeloid-mixed-phenotype-acute-leukemia-with-t-v-11q23-kmt2a-rearrangement-successfully-treated-by-allogeneic-stem-cell-transplant
#40
Suhayb Syed, Amy Song, Mohammad Hussaini
Mixed phenotype acute leukemia (MPAL) consists of a leukemia of two different lineages (myeloid, T, and/or B) co-occurring in the same tissue. KMT2A-rearrangement is rare and usually seen in B/myeloid MPAL. We report a unique case of T/myeloid MPAL with a t(v;11q23) KMT2A-rearrangement, with acute myeloid leukemia (AML) in the bone marrow but concurrent T-cell acute lymphoblastic leukemia (T-ALL) in lymph node and skin. Genomic interrogation suggests an undifferentiated stem cells with KMT2A rearrangement as the founder mutation that acquired additional lineage-specific mutations resulting in AML in the marrow and T-ALL in other sites...
2022: Leukemia Research Reports
keyword
keyword
70934
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.