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quantitative image analysis

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https://www.readbyqxmd.com/read/28636919/monitoring-quantitative-ultrasound-parameter-changes-in-a-cell-pellet-model-of-cell-starvation
#1
Lauren A Wirtzfeld, Elizabeth S L Berndl, Gregory J Czarnota, Michael C Kolios
Although it has previously been shown that the spectral analysis of ultrasound backscatter data is sensitive to the cellular changes caused by apoptosis, the sensitivity of spectral analysis to oncosis or ischemic cell death had not previously been studied. Whereas many anticancer treatments induce apoptosis, others induce cell starvation, or oncosis. HT-29 colon adenocarcinoma cells were formed into pellets and covered in phosphate-buffered saline at room temperature for 56 h. The pellets were imaged every 8 h with high-frequency (55 MHz) ultrasound and the raw radio-frequency data processed...
June 20, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28633840/changes-in-pore-size-distribution-inside-sludge-under-various-ultrasonic-conditions
#2
Fang Zhao, Daolai Cheng
The pore size distribution is quite significant for determining the transport capacity of heat and moisture in sludge during the drying process. It is crucial to investigate the transformation of the pore size in sludge under sonication. In this paper, the microstructures of pores inside sludge before and after ultrasonic treatment with various ultrasonic conditions were observed using a microscope. Fractal geometry and image analysis were combined to quantitatively identify the evolution of pore size in sludge undergoing various acoustic energy densities and treatment times...
September 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28633438/sandpuma-ensemble-predictions-of-nonribosomal-peptide-chemistry-reveals-biosynthetic-diversity-across-actinobacteria
#3
Marc G Chevrette, Fabian Aicheler, Oliver Kohlbacher, Cameron R Currie, Marnix H Medema
Summary: Nonribosomally synthesized peptides (NRPs) are natural products with widespread applications in medicine and biotechnology. Many algorithms have been developed to predict the substrate specificities of nonribosomal peptide synthetase adenylation (A) domains from DNA sequences, which enables prioritization and dereplication, and integration with other data types in discovery efforts. However, insufficient training data and a lack of clarity regarding prediction quality have impeded optimal use...
June 19, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28632688/high-quality-3-dimensional-1h-magnetic-resonance-spectroscopic-imaging-of-the-prostate-without-endorectal-receive-coil-using-a-semi-laser-sequence
#4
Nassim Tayari, Isabell K Steinseifer, Kirsten M Selnæs, Tone F Bathen, Marnix C Maas, Arend Heerschap
OBJECTIVES: Inclusion of 3-dimensional H magnetic resonance spectroscopic imaging (3D-H-MRSI) in routine multiparametric MRI of the prostate requires good quality spectra and easy interpretable metabolite maps of the whole organ obtained without endorectal coil in clinically feasible acquisition times. We evaluated if a semi-LASER pulse sequence with gradient offset independent adiabaticity refocusing pulses (GOIA-sLASER) for volume selection can meet these requirements. MATERIALS AND METHODS: Thirteen patients with suspicion of prostate cancer and 1 patient known to have prostate cancer were examined at 3 T with a multichannel body-receive coil...
June 19, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28631633/significance-of-vascular-endothelial-growth-factor-and-cd31-and-morphometric-analysis-of-microvessel-density-by-cd31-receptor-expression-as-an-adjuvant-tool-in-diagnosis-of-psoriatic-lesions-of-skin
#5
Nitika Chawla, Sant Prakash Kataria, Kamal Aggarwal, Pardeep Chauhan, Dinesh Kumar
BACKGROUND: Pathogenesis of psoriasis is a debated issue. Several mechanisms have been proposed to identify the etiology and pathogenesis so that specific treatments can be given to patients with psoriasis. AIMS: (1) To compare pattern and distribution of vascular endothelial growth factor (VEGF) and CD31 in patients with psoriasis and other psoriasiform lesions of skin. (2) To study the correlation between VEGF and CD31 expression, clinical severity, and histopathology of psoriasiform lesions of skin...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28630930/real-time-quantitative-analysis-of-metabolic-flux-in-live-cells-using-a-hyperpolarized-micromagnetic-resonance-spectrometer
#6
Sangmoo Jeong, Roozbeh Eskandari, Sun Mi Park, Julio Alvarez, Sui Seng Tee, Ralph Weissleder, Michael G Kharas, Hakho Lee, Kayvan R Keshari
Metabolic reprogramming is widely considered a hallmark of cancer, and understanding metabolic dynamics described by the conversion rates or "fluxes" of metabolites can shed light onto biological processes of tumorigenesis and response to therapy. For real-time analysis of metabolic flux in intact cells or organisms, magnetic resonance (MR) spectroscopy and imaging methods have been developed in conjunction with hyperpolarization of nuclear spins. These approaches enable noninvasive monitoring of tumor progression and treatment efficacy and are being tested in multiple clinical trials...
June 2017: Science Advances
https://www.readbyqxmd.com/read/28629954/high-resolution-myelin-water-imaging-incorporating-local-tissue-susceptibility-analysis
#7
Zhe Wu, Hongjian He, Yi Sun, Yiping Du, Jianhui Zhong
Quantitative myelin water imaging (MWI) from signal T2* decay acquired with multiple Gradient-Recalled Echo (mGRE) sequence has been widely used since its first report. A recent study showed that with low resolution data (2mm isotropic voxels), direct application of complex fitting to a three-pool WM model with frequency shift terms could produce more stable parameter estimation for myelin water fraction mapping. MWI maps of higher spatial resolution resulting in more detailed tissue structures and reduced partial volume effects around white matter/gray matter (WM/GM) interface, however, is more desirable...
June 16, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/28629625/what-exactly-regression-of-atherosclerosis-or-foreign-body-reaction-with-hyaline-arteriosclerosis-drives-transient-scaffolding-of-coronary-arteries-a-pooled-analysis-of-observational-absorb-studies-with-a-serial-multimodality-imaging-substudy-of-absorb-cohort
#8
Alexander N Kharlamov, John A Feinstein, John A Cramer, John A Boothroyd
OBJECTIVES: We aimed to estimate the trends of the artery remodeling after transient scaffolding. BACKGROUND: At least 2.62% reduction of the per cent atheroma volume (PAV) or plaque burden (PB) performed in ABSORB B trial at 60months. METHODS: The detailed multiple serial imaging evaluation was performed by intravascular ultrasound (IVUS) in comparison with quantitative coronary angiography (QCA), multislice CT (MSCT) and optical coherence tomography (OCT) thru 24months in the ABSORB cohort B1 trial (n=45) with the pooled analysis in ABSORB A and B trials (n=131)...
June 6, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28629416/ct-texture-features-are-associated-with-overall-survival-in-pancreatic-ductal-adenocarcinoma-a-quantitative-analysis
#9
Armin Eilaghi, Sameer Baig, Yucheng Zhang, Junjie Zhang, Paul Karanicolas, Steven Gallinger, Farzad Khalvati, Masoom A Haider
BACKGROUND: To assess whether CT-derived texture features predict survival in patients undergoing resection for pancreatic ductal adenocarcinoma (PDAC). METHODS: Thirty patients with pre-operative CT from 2007 to 2012 for PDAC were included. Tumor size and five texture features namely uniformity, entropy, dissimilarity, correlation, and inverse difference normalized were calculated. Mann-Whitney rank sum test was used to compare tumor with normal pancreas. Receiver operating characteristics (ROC) analysis, Cox regression and Kaplan-Meier tests were used to assess association of texture features with overall survival (OS)...
June 19, 2017: BMC Medical Imaging
https://www.readbyqxmd.com/read/28629003/a-simple-semi-quantitative-approach-studying-the-in-vivo-degradation-of-regenerated-silk-fibroin-scaffolds-with-different-pore-sizes
#10
Yongwei Guo, Zhongchun Chen, Jianchuan Wen, Minghui Jia, Zhengzhong Shao, Xia Zhao
The biocompatibility and in vivo degradation rate of biomaterials represent critical control points in the long-term success of scaffolds for tissue restoration. In this study, new three-dimensional (3D) regenerated silk fibroin scaffolds (RSFs) were prepared by the freezing-defrosting procedure, and then were implanted beneath the dorsal skin of rats. This study aims to develop a kinetic semi-quantitative approach to assess in vivo degradation rate and biocompatibility of this kind of RSFs with different pore sizes for the first time, and to evaluate the relationship between the biodegradation and tissue responses by measuring the thickness of residual scaffolds, fibrous capsules and infiltrated tissues through integrated techniques of histology, optical imaging and image analysis...
October 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28628808/quantitative-image-analysis-of-the-shape-and-size-of-circular-wound-sites-generated-by-vertically-stamped-scratches
#11
Tae Young Kim, In Hyuk Jang, Dong Yeol Han, Won Gu Lee
A protocol for quantitative image analysis of wound generation is important to better understand the integrative process of wound healing and the closure mechanism. Here, we present a method for quantitative analysis of microscopic images of circular wound sites generated by vertically stamped scratches. To demonstrate proof-of-concept validation, we used two types of mechanical stamping tools, a mechanical pencil lead (type 1; brittle) and polydimethylsiloxane (PDMS) pillars (type 2; ductile), to create circular wound sites...
June 9, 2017: Micron: the International Research and Review Journal for Microscopy
https://www.readbyqxmd.com/read/28627941/detecting-social-cognitive-deficits-after-traumatic-brain-injury-an-ale-meta-analysis-of-fmri-studies
#12
Hui Xiao, Andre Jacobsen, Ziqian Chen, Yang Wang
PURPOSE: Traumatic brain injury (TBI) can result in significant social dysfunction, which is represented by impairment to social-cognitive abilities (i.e. social cognition, social attention/executive function and communication). This study is aimed to explore brain networks mediating the social dysfunction after TBI and its underlying mechanisms. METHODS: We performed a quantitative meta-analysis using the activation likelihood estimation (ALE) approach on functional magnetic resonance imaging (fMRI) studies of social-cognitive abilities following TBI...
June 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28625242/-clinical-significance-of-combined-detection-of-peripheral-mir-182-and-il-17-in-the-early-diagnosis-of-patients-with-eclampsia-complicated-with-cerebral-infarction-in-icu
#13
Lina Zhang, Tiejun Wu, Dawei Wu, Yanjun Liu, Min Bai, Shuangfeng Chen
OBJECTIVE: To observe the effect of peripheral blood microRNA-182 (miR-182) combined with interleukin-17 (IL-17) in the early diagnosis of cerebral infarction (CI) in patients with eclampsia. METHODS: A prospective non-randomized controlled study was conducted. The patients with eclampsia admitted to intensive care unit (ICU) of Liaocheng People's Hospital from January 1st, 2013 to September 30th 2016 were enrolled. Cerebral imaging was conducted in 7 days after admission to make a definite diagnosis of the occurrence of CI, excluding patients with cerebral hemorrhage...
June 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/28625174/quantification-of-cardiomyocyte-alignment-from-three-dimensional-3d-confocal-microscopy-of-engineered-tissue
#14
William J Kowalski, Fangping Yuan, Takeichiro Nakane, Hidetoshi Masumoto, Marc Dwenger, Fei Ye, Joseph P Tinney, Bradley B Keller
Biological tissues have complex, three-dimensional (3D) organizations of cells and matrix factors that provide the architecture necessary to meet morphogenic and functional demands. Disordered cell alignment is associated with congenital heart disease, cardiomyopathy, and neurodegenerative diseases and repairing or replacing these tissues using engineered constructs may improve regenerative capacity. However, optimizing cell alignment within engineered tissues requires quantitative 3D data on cell orientations and both efficient and validated processing algorithms...
June 19, 2017: Microscopy and Microanalysis
https://www.readbyqxmd.com/read/28624925/liver-fibrosis-in-vivo-evaluation-using-intravoxel-incoherent-motion-derived-histogram-metrics-with-histopathologic-findings-at-3-0-t
#15
Fubi Hu, Ru Yang, Zixing Huang, Min Wang, Hanmei Zhang, Xu Yan, Bin Song
PURPOSE: To retrospectively determine the feasibility of intravoxel incoherent motion (IVIM) imaging based on histogram analysis for the staging of liver fibrosis (LF) using histopathologic findings as the reference standard. METHODS: 56 consecutive patients (14 men, 42 women; age range, 15-76, years) with chronic liver diseases (CLDs) were studied using IVIM-DWI with 9 b-values (0, 25, 50, 75, 100, 150, 200, 500, 800 s/mm(2)) at 3.0 T. Fibrosis stage was evaluated using the METAVIR scoring system...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28624924/evaluation-of-hepatic-fibrosis-a-review-from-the-society-of-abdominal-radiology-disease-focus-panel
#16
REVIEW
Jeanne M Horowitz, Sudhakar K Venkatesh, Richard L Ehman, Kartik Jhaveri, Patrick Kamath, Michael A Ohliger, Anthony E Samir, Alvin C Silva, Bachir Taouli, Michael S Torbenson, Michael L Wells, Benjamin Yeh, Frank H Miller
Hepatic fibrosis is potentially reversible; however early diagnosis is necessary for treatment in order to halt progression to cirrhosis and development of complications including portal hypertension and hepatocellular carcinoma. Morphologic signs of cirrhosis on ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) alone are unreliable and are seen with more advanced disease. Newer imaging techniques to diagnose liver fibrosis are reliable and accurate, and include magnetic resonance elastography and US elastography (one-dimensional transient elastography and point shear wave elastography or acoustic radiation force impulse imaging)...
June 17, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28624592/post-anoxic-quantitative-mri-changes-may-predict-emergence-from-coma-and-functional-outcomes-at-discharge
#17
Alexandra S Reynolds, Xiaotao Guo, Elizabeth Matthews, Daniel Brodie, Leroy E Rabbani, David J Roh, Soojin Park, Jan Claassen, Mitchell S V Elkind, Binsheng Zhao, Sachin Agarwal
BACKGROUND: Traditional predictors of neurological prognosis after cardiac arrest are unreliable after targeted temperature management. Absence of pupillary reflexes remains a reliable predictor of poor outcome. Diffusion-weighted imaging has emerged as a potential predictor of recovery, and here we compare imaging characteristics to pupillary exam. METHODS: We identified 69 patients who had MRIs within seven days of arrest and used a semi-automated algorithm to perform quantitative volumetric analysis of apparent diffusion coefficient (ADC) sequences at various thresholds...
June 15, 2017: Resuscitation
https://www.readbyqxmd.com/read/28624025/quantitative-computed-tomography-texture-analysis-for-estimating-histological-subtypes-of-thymic-epithelial-tumors
#18
Koichiro Yasaka, Hiroyuki Akai, Masanori Nojima, Aya Shinozaki-Ushiku, Masashi Fukayama, Jun Nakajima, Kuni Ohtomo, Shigeru Kiryu
OBJECTIVES: To investigate whether high-risk thymic epithelial tumor (TET) (HTET) can be differentiated from low-risk TET (LTET) using computed tomography (CT) quantitative texture analysis. MATERIALS AND METHODS: The data of 39 patients (mean age, 58.6±14.1 years) (39 unenhanced CT (UECT) and 33 contrast-enhanced CT (CECT)) who underwent thymectomy for TET were retrospectively analyzed. A region of interest was placed to include the entire TET within the slice at its maximum diameter...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624017/association-of-pharmacokinetic-and-metabolic-parameters-derived-using-simultaneous-pet-mri-initial-findings-and-impact-on-response-evaluation-in-breast-cancer
#19
Amarnath Jena, Sangeeta Taneja, Aru Singh, Pradeep Negi, Shashi Bhushan Mehta, Aashim Ahuja, Manish Singhal, Ramesh Sarin
PURPOSE: To study relationships among pharmacokinetic and (18)F-fluorodeoxyglucose ((18)F-FDG) PET parameters obtained through simultaneous PET/MRI in breast cancer patients and evaluate their combined potential for response evaluation. METHODS: The study included 41 breast cancer patients for correlation study and 9 patients (pre and post therapy) for response evaluation. All patients underwent simultaneous PET/MRI with dedicated breast imaging. Pharmacokinetic parameters and PET parameters for tumor were derived using an in- house developed and vendor provided softwares respectively...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624012/differentiation-of-small-intrahepatic-mass-forming-cholangiocarcinoma-from-small-liver-abscess-by-dual-source-dual-energy-ct-quantitative-parameters
#20
Ji Eun Kim, Hyun Ok Kim, Kyungsoo Bae, Jae Min Cho, Ho Cheol Choi, Dae Seob Choi
PURPOSE: To investigate the use of dual source dual-energy CT (DECT) quantitative parameters compared with the use of conventional CT for differentiating small (≤3cm) intrahepatic mass-forming cholangiocarcinoma (IMCC) from small liver abscess (LA) during the portal venous phase (PVP). MATERIAL AND METHODS: In this institutional review board-approved, retrospective study, 64 patients with IMCCs and 52 patients with LAs who were imaged in PVP using dual-energy mode were included retrospectively...
July 2017: European Journal of Radiology
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