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https://www.readbyqxmd.com/read/29331505/successful-treatment-of-anti-angiotensin-ii-type-1-receptor-antibody-associated-rejection-in-kidney-transplantation-a-case-report
#1
P Wiwattanathum, A Ingsathit, D Thammanichanond, S Worawichawong
Angiotensin II type 1 receptor (AT1R) antibody, a non-HLA antibody, has been found to have a detrimental effect on kidney allografts. Similarly to HLA antibodies, recipients who have AT1R antibodies are at risk for allograft rejection and poor long-term graft outcome. Besides mediating allograft rejections via direct effects on endothelial and vascular smooth muscle without complement activation, AT1R antibodies may lead to accelerated hypertension via the renin-angiotensin pathway. There has been no definite level of AT1R antibody that predicts allograft rejection...
January 10, 2018: Transplantation Proceedings
https://www.readbyqxmd.com/read/29330517/iron-induced-calcification-in-human-aortic-vascular-smooth-muscle-cells-through-interleukin-24-il-24-with-without-tnf-alpha
#2
Sayuri Kawada, Yasuyuki Nagasawa, Mutsuki Kawabe, Hideki Ohyama, Aritoshi Kida, Nahoko Kato-Kogoe, Masayoshi Nanami, Yukiko Hasuike, Takahiro Kuragano, Hiromitsu Kishimoto, Keiji Nakasho, Takeshi Nakanishi
In CKD patients, arteriosclerotic lesions, including calcification, can occur in vascular smooth muscle cells in a process called Moenckeberg's medial arteriosclerosis. Iron overload induces several complications, including the acceleration of arteriosclerosis. However, the relationship between Moenckeberg's arteriosclerosis in vascular smooth muscle cells and iron accumulation has remained unknown. We tested the accelerated effect of iron on calcification in cultured human aortic vascular smooth muscle cells (HASMCs)...
January 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29330066/regulation-of-vascular-tone-homeostasis-by-no-and-h2s-implications-in-hypertension
#3
REVIEW
Sevda Gheibi, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi
Nitric oxide (NO) and hydrogen sulfide (H2S) are two gasotransmitters that are produced in the vasculature and contribute to the regulation of vascular tone. NO and H2S are synthesized in both vascular smooth muscle and endothelial cells; NO functions primarily through the sGC/cGMP pathway, and H2S mainly through activation of the ATP-dependent potassium channels; both leading to relaxation of vascular smooth muscle cells. A deficit in the NO/H2S homeostasis is involved in the pathogenesis of various cardiovascular diseases, especially hypertension...
January 9, 2018: Biochemical Pharmacology
https://www.readbyqxmd.com/read/29328431/bioinformatic-analysis-of-gene-expression-profiling-of-intracranial-aneurysm
#4
Lijuan Bo, Bo Wei, Zhanfeng Wang, Chaohui Li, Zheng Gao, Zhuang Miao
Intracranial aneurysm (IA) is a severe clinical condition of primary concern and currently, there is no effective therapeutic reagent. The present study aimed to investigate the molecular mechanism of IA via bioinformatic analysis. Various gene expression profiles (GSE26969) were downloaded from the Gene Expression Omnibus database, including 3 IA and 3 normal superficial temporal artery samples. Firstly, the limma package in R language was used to identify differentially expressed genes (DEGs; P‑value <0...
December 29, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29327677/autologous-smooth-muscle-progenitor-cells-enhance-regeneration-of-tissue-engineered-bladder
#5
Liuhua Zhou, Jiadong Xia, Pengji Wang, Ruipeng Jia, Jun Hua Zheng, Xudong Yao, Yun Chen, Yutian Dai, Bin Yang
Tissue engineering techniques provide a great potential to de novo construct a histological bladder. Smooth muscle regeneration is extremely important for the functional recovery of engineered neo-bladder. However, many challenges remain for the use of bladder smooth muscle cells (SMCs) as the cell sources. Recent evidences showed that smooth muscle progenitor cells (SPCs) in the peripheral blood have the capacity of differentiating into SMCs, while their use for bladder regeneration hasn't yet been reported...
January 12, 2018: Tissue Engineering. Part A
https://www.readbyqxmd.com/read/29327345/serum-lipoprotein-a-predicts-acute-coronary-syndromes-in-patients-with-severe-carotid-stenosis
#6
Fabio Rigamonti, Federico Carbone, Fabrizio Montecucco, Aldo Bonaventura, Luca Liberale, Fabienne Burger, Aline Roth, Maria Bertolotto, Giovanni Spinella, Bianca Pane, Domenico Palombo, Aldo Pende, Franco Dallegri, François Mach, Stefano Bertolini, Livia Pisciotta
Different cut-off values of serum lipoprotein(a) [Lp(a)] were recently identified in order to better stratify cardiovascular risk categories. Both pathophysiological and prognostic values of Lp(a) remain unclear. Here, the prognostic value of Lp(a) and its correlation with intraplaque features were assessed in patients with severe carotid artery stenosis undergoing endarterectomy (n=180). The cut-off value of 10 mg/dL for serum Lp(a) was selected to predict 24-month follow-up acute coronary syndrome (ACS). In addition, the association between serum Lp(a) and intraplaque lipids, collagen, inflammatory and vascular cells was assessed...
January 11, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29326878/ten-year-long-enzyme-replacement-therapy-shows-a-poor-effect-in-alleviating-giant-leg-ulcers-in-a-male-with-fabry-disease
#7
Jun Okada, Mohammad Arif Hossain, Chen Wu, Takashi Miyajima, Hiroko Yanagisawa, Keiko Akiyama, Yoshikatsu Eto
Fabry disease is an X-linked lysosomal storage disorder caused by a deficiency of α-galactosidase A (α-gal A), leading to the progressive accumulation of glycosphingolipids. Classical hemizygous males usually present symptoms, including pain and paresthesia in the extremities, angiokeratoma, hypo- or anhidrosis, abdominal pain, cornea verticillata, early stroke, tinnitus, and/or hearing loss, during early childhood or adolescence. Moreover, proteinuria, renal impairment, and cardiac hypertrophy can appear with age...
March 2018: Molecular Genetics and Metabolism Reports
https://www.readbyqxmd.com/read/29326316/fibronectin-containing-extra-domain-a-induces-plaque-destabilization-in-the-innominate-artery-of-aged-apolipoprotein-e-deficient-mice
#8
Prakash Doddapattar, Manish Jain, Nirav Dhanesha, Steven R Lentz, Anil K Chauhan
OBJECTIVE: Fibronectin containing extra domain A (Fn-EDA) is an endogenous ligand of TLR4 (toll-like receptor 4) and is abundant in the extracellular matrix of advanced atherosclerotic lesions in human and mice. Irrespective of sex, deletion of Fn-EDA reduces early atherosclerosis in apolipoprotein E-deficient (Apoe-/-) mice. However, the contribution of Fn-EDA in advanced atherosclerosis remains poorly characterized. We determined the contribution of Fn-EDA in advanced atherosclerotic lesions of aged (1-year-old) Apoe-/- mice...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326312/foxo3a-forkhead-transcription-factor-o-subfamily-member-3a-links-vascular-smooth-muscle-cell-apoptosis-matrix-breakdown-atherosclerosis-and-vascular-remodeling-through-a-novel-pathway-involving-mmp13-matrix-metalloproteinase-13
#9
Haixiang Yu, Adam Fellows, Kirsty Foote, Zhaoqing Yang, Nichola Figg, Trevor Littlewood, Martin Bennett
OBJECTIVE: Vascular smooth muscle cell (VSMC) apoptosis accelerates atherosclerosis and promotes breakdown of the extracellular matrix, but the mechanistic links between these 2 processes are unknown. The forkhead protein FOXO3a (forkhead transcription factor O subfamily member 3a) is activated in human atherosclerosis and induces a range of proapoptotic and other transcriptional targets. We, therefore, determined the mechanisms and consequences of FOXO3a activation in atherosclerosis and arterial remodeling after injury...
January 11, 2018: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29326163/lim-and-cysteine-rich-domains-1-is-required-for-thrombin-induced-smooth-muscle-cell-proliferation-and-promotes-atherogenesis
#10
Jagadeesh Janjanam, Baolin Zhang, Arul M Mani, Nikhlesh K Singh, James G Traylor, A Wayne Orr, Gadiparthi N Rao
Restenosis arises after vascular injury and is characterized by arterial wall thickening and decreased arterial lumen space. Vascular injury induces the production of thrombin, which in addition to its role in blood clotting, acts as a mitogenic and chemotactic factor. In exploring the molecular mechanisms underlying restenosis, here we identified LIM and cysteine-rich domains 1 (LMCD1) as a gene highly responsive to thrombin in human aortic smooth muscle cells (HASMCs). Of note, LMCD1 depletion inhibited proliferation of human but not murine vascular smooth muscle cells...
January 11, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29325741/functional-engineered-mesenchymal-stem-cells-with-fibronectin-gold-composite-coated-catheters-for-vascular-tissue-regeneration
#11
Yun-Wen Chen, Shu-Chen Hsieh, Yi-Chin Yang, Shan-Hui Hsu, Mei-Lang Kung, Pei-Ying Lin, Hsien-Hsu Hsieh, Ching-Hao Lin, Cheng-Ming Tang, Huey-Shan Hung
Vascularization of engineered tissues remains one of the key problems. Here, we described a novel approach to promote vascularization of engineered tissues using fibronectin (FN) incorporated gold nanoparticles (AuNP) coated onto catheters with mesenchymal stem cells (MSCs) for tissue engineering. We found that the FN-AuNP composite with 43.5 ppm of AuNP exhibited better biomechanical properties and thermal stability than pure FN. FN-AuNP composites promoted MSC proliferation and increased the biocompatibility...
January 8, 2018: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29324316/microrna-145-alleviates-high-glucose-induced-proliferation-and-migration-of-vascular-smooth-muscle-cells-through-targeting-rock1
#12
Mantian Chen, Yi Zhang, Wei Li, Jieying Yang
The excessive proliferation and migration of vascular smooth muscle cells (VSMCs) are important steps in atherosclerosis. The present study aimed to investigate whether the high glucose-induced changes of VSCMs are mediated by miR-145 and the potential molecular mechanism involved. We found that loss of miR-145 accompanied with increased proliferation and migration was observed in cultured human VSMCs exposed to high glucose. Exogenous overexpression of miR-145 effectively suppressed the high glucose-induced excessive proliferation and migration of VSMCs...
January 8, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29324062/four-day-pulse-of-sodium-cromoglycate-modulates-pulmonary-vessel-wall-remodeling-during-21-day-hypoxia-in-rats
#13
Tomáš Novotný, Jiří Uhlík, Luděk Vajner
AIM OF THE STUDY: Remodeling of pulmonary resistance arteries in rats due to 4-day hypoxia could be successfully suppressed by sodium cromoglycate. In this study, we tested the difference in the suppression between two distinct time patterns of cromoglycate administration during 21-day hypoxia. In the experiment, we focused on some details in both smooth muscle cells and extracellular matrix of pulmonary arterial walls. METHODS: During 21-day hypoxia, rats were treated with sodium cromoglycate either in the first four days or in the last four days...
January 11, 2018: Experimental Lung Research
https://www.readbyqxmd.com/read/29323138/whole-mount-adult-ear-skin-imaging-reveals-defective-neuro-vascular-branching-morphogenesis-in-obese-and-type-2-diabetic-mouse-models
#14
Tomoko Yamazaki, Wenling Li, Ling Yang, Ping Li, Haiming Cao, Sei-Ichiro Motegi, Mark C Udey, Elise Bernhard, Takahisa Nakamura, Yoh-Suke Mukouyama
Obesity and type 2 diabetes are frequently associated with peripheral neuropathy. Though there are multiple methods for diagnosis and analysis of morphological changes of peripheral nerves and blood vessels, three-dimensional high-resolution imaging is necessary to appreciate the pathogenesis with an anatomically recognizable branching morphogenesis and patterning. Here we established a novel technique for whole-mount imaging of adult mouse ear skin to visualize branching morphogenesis and patterning of peripheral nerves and blood vessels...
January 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321689/analysis-of-combined-transcriptomes-identifies-gene-modules-that-differentially-respond-to-pathogenic-stimulation-of-vascular-smooth-muscle-and-endothelial-cells
#15
Xiaokang Pan, Bowen Wang, Tiezheng Yuan, Mengxue Zhang, K Craig Kent, Lian-Wang Guo
Smooth muscle cells (SMCs) and endothelial cells (ECs) are vital cell types composing the vascular medial wall and the atheroprotective inner lining, respectively. Current treatments for cardiovascular disease inhibit SMC hyperplasia but compromise EC integrity, predisposing patients to thrombosis. Therapeutics targeting SMCs without collateral damage to ECs are highly desirable. However, differential (SMC versus EC) disease-associated regulations remain poorly defined. We conducted RNA-seq experiments to investigate SMC-versus-EC differential transcriptomic dynamics, following treatment of human primary SMCs and ECs with TNFα or IL-1β, both established inducers of SMC hyperplasia and EC dysfunction...
January 10, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29321388/suppression-of-abdominal-aortic-aneurysm-formation-in-mice-by-teneligliptin-a-dipeptidyl-peptidase-4-inhibitor
#16
Yusuke Takahara, Tomotake Tokunou, Toshihiro Ichiki
AIM: Dipeptidyl peptidase-4 (DPP-4) inhibitors lower blood glucose levels through inhibition of incretin degradation, which stimulates insulin secretion. Recent studies reported that DPP-4 inhibitors suppressed atherogenesis in apolipoprotein E-knockout (ApoEKO) mice. In this study, we investigated whether teneligliptin, a DPP-4 inhibitor, affects the development of abdominal aortic aneurysms (AAA) in ApoEKO mice. METHODS: ApoEKO mice were fed a high-fat diet (HFD) and infused with angiotensin (Ang) II by osmotic mini pumps for 4 weeks to induce AAA with (DPP-4i group) or without (control group) teneligliptin administered orally from 1 week before HFD and Ang II infusion to the end of the experiment...
January 10, 2018: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/29319186/the-large-conductance-voltage-and-ca2-activated-k-channel-and-its-%C3%AE-1-subunit-modulate-mouse-uterine-artery-function-during-pregnancy
#17
Ramón A Lorca, Monali Wakle-Prabagaran, William E Freeman, Meghan K Pillai, Sarah K England
Insufficient vasodilation of the uterine artery (UA) during pregnancy leads to poor utero-placental perfusion, contributing to intrauterine growth restriction and fetal loss. Activity of the large conductance Ca2+ -activated K+ (BKCa ) channel increases in the UA during pregnancy, and its inhibition reduces uterine blood flow, highlighting a role of this channel in UA adaptation to pregnancy. The auxiliary γ1-subunit increases BKCa activation in vascular smooth muscle, but its role in pregnancy-associated UA remodelling is unknown...
January 10, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29317587/-progress-in-the-study-on-roles-of-cathepsin-in-hypertension
#18
Zhouyangfan Peng, Yapei Li, Pingyu Zeng, Xiaohui Li
Cardiovascular remodeling or dysfunction-induced abnormal cardiac output, blood volume and peripheral vascular resistance is an important pathophysiological mechanism for the occurrence and development of hypertension. Cathepsins are widely expressed in human various tissue and cells and they are involved in the pathogenesis of hypertension through activation of renin - angiotensin system, degradation of cytoplasmic matrix, proliferation of smooth muscle cell and hypertrophy of myocyte. The clinical studies have found that cathepsins can be used as a biomarker for hypertension...
December 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/29310814/microarray-expression-profile-analysis-of-long-non-coding-rnas-in-thoracic-aortic-aneurysm
#19
Yang Li, Nan Yang
Thoracic aortic aneurysm (TAA) is a highly lethal vascular disease. Long non-coding RNAs (lncRNAs) are newly discovered as a regulator of protein genes and play critical roles in cardiovascular physio-pathological processes. However, there were a few studies looking at lncRNAs in TAA. In this study, we profiled differential expression of lncRNAs between TAA (TAA group, N = 6) and normal thoracic aorta (control group, n = 6) by third-generation lncRNA microarray. We identified 1352 up-regulated and 1624 down-regulated lncRNAs with differential expression (log fold-change > 2...
January 2018: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29310805/basic-components-of-vascular-connective-tissue-and-extracellular-matrix
#20
Jaroslava Halper
Though the composition of the three layers constituting the blood vessel wall varies among the different types of blood vessels, and some layers may even be missing in capillaries, certain basic components, and properties are shared by all blood vessels, though each histologically distinct layer contains a unique complement of extracellular components, growth factors and cytokines, and cell types as well. The structure and composition of vessel layers informs and is informed by the function of the particular blood vessel...
2018: Advances in Pharmacology
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