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https://www.readbyqxmd.com/read/29057497/molecular-modeling-studies-to-explore-the-binding-affinity-of-virtually-screened-inhibitor-towards-different-aminoglycoside-kinases-from-diverse-mdr-strains
#1
Rishikesh S Parulekar, Kailas D Sonawane
Antibiotic resistance to aminoglycoside group of antibiotics mainly occurs by aminoglycoside kinases (AKs). Thus, targeting AKs from different multidrug resistant (MDR) strains could result into inhibition of AK enzymes and ultimately the resistance. Therefore, the present study aims to target one of these AKs i.e. APH(3')-Ia from Acinetobacter baumannii through structure based virtual screening (SBVS) and test the binding affinity of the most stable virtually screened inhibitor with AKs from Mycobacterium tuberculosis, Acinetobacter baumannii, Enterococcus gallinarum and Escherichia coli...
October 23, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29053085/rifampicin-resistance-and-multidrug-resistant-tuberculosis-detection-using-xpert-mtb-rif-in-wuhan-china-a-retrospective-study
#2
Hai Huang, Yanlin Zhang, Sheng Li, Jun Wang, Jun Chen, Zhiyun Pan, Hui Gan
BACKGROUND: The Xpert MTB/RIF test (Cepheid, Sunnyvale, CA) can simultaneously detect the Mycobacterium tuberculosis (MTB) complex DNA and rifampicin (RFP) resistance and can rapidly determine RFP resistance and predict multidrug-resistant tuberculosis (MDR-TB). In this study, we analyzed clinical examination results of a hospital specializing in TB treatment in Wuhan, Hubei, China, and examined the use of traditional culture and drug-sensitive test (DST) results as a gold standard to assess the diagnosis value of the Xpert MTB/RIF test in RFP resistance and MDR-TB...
October 20, 2017: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29050769/prevalence-of-beijing-and-haarlem-genotypes-among-multidrug-resistant-mycobacterium-tuberculosis-in-iran-systematic-review-and-meta-analysis
#3
REVIEW
Samira Tarashi, Abolfazl Fateh, Fatemeh Rahimi Jamnani, Seyed Davar Siadat, Farzam Vaziri
Antimicrobial drug resistance creates major problems in the control of tuberculosis (TB). Beijing and Haarlem genotypes of Mycobacterium tuberculosis are the prevalent genotypes responsible for multidrug resistant (MDR) TB worldwide. The aim of this study was to conduct a systematic review using meta-analysis to indicate the prevalence of Beijing and Haarlem genotypes among MDR-TB cases in Iran. Data sources of current study were 311 original articles (2006-2016) that were searched in several databases including Medline, Scopus, Embase, Cochrane library, and Iranian databases...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050755/applied-multiplex-allele-specific-pcr-to-detect-second-line-drug-resistance-among-multidrug-resistant-tuberculosis-in-china
#4
Ya-Ping Liang, Yan Chen, Tong-Yang Xiao, Qiang Xia, Hai-Can Liu, Xiu-Qin Zhao, Chun-Yan Zeng, Li-Li Zhao, Kang-Lin Wan
Rapid detection of resistance to the second-line drugs is essential for early initiation of appropriate anti-tubercular treatment regimen among multi-drug tuberculosis (MDR-TB). In this study, we applied a multiplex allele-specific PCR (MAS-PCR) to identify the mutations on codons 90 and 94 of gyrA and nucleotide 1401 of rrs for detecting ofloxacin (OFX) and kanamycin (KAN) resistance in 139 MDR-TB isolates from China. Using the traditional phenotypic method as the reference, MAS-PCR detected resistance to OFX and KAN with sensitivities of 67...
December 2017: Tuberculosis
https://www.readbyqxmd.com/read/29050672/genetic-diversity-of-multidrug-resistant-mycobacterium-tuberculosis-strains-isolated-from-tuberculosis-patients-in-iran-using-miru-vntr-technique
#5
Azar Dokht Khosravi, Abdolrazagh Hashemi Shahraki, Soolmaz Khandan Dezfuli, Mohammad Hashemzadeh, Hamed Goodarzi, Parviz Mohajeri
Tuberculosis (TB) is considered as one of the most important infectious diseases in the world, and recent rise and spread of multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains, have made the matter worsened. Due to the importance of TB prevalence in Iran, this study was designed to investigate the genetic diversity among MDR strains of MTB by MIRU-VNTR typing scheme. A total of 88 drug resistant M. tuberculosis isolates belong to pulmonary TB cases were collected from several TB reference centers of Iran...
November 2017: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/29041901/prevalence-of-drug-resistant-pulmonary-tuberculosis-in-india-systematic-review-and-meta-analysis
#6
Vishal Goyal, Vijay Kadam, Prashant Narang, Vikram Singh
BACKGROUND: Drug-resistant pulmonary tuberculosis (DR-TB) is a significant public health issue that considerably deters the ongoing TB control efforts in India. The purpose of this review was to investigate the prevalence of DR-TB and understand the regional variation in resistance pattern across India from 1995 to 2015, based on a large body of published epidemiological studies. METHODS: A systematic review of published studies reporting prevalence of DR-TB from biomedical databases (PubMed and IndMed) was conducted...
October 17, 2017: BMC Public Health
https://www.readbyqxmd.com/read/29040413/bilateral-cavitary-multidrug-or-extensively-drug-resistant-tuberculosis-role-of-surgery
#7
Galina Yu Marfina, Kirill B Vladimirov, Armen O Avetisian, Anna A Starshinova, Grigorii G Kudriashov, Evgenii G Sokolovich, Piotr K Yablonskii
OBJECTIVES: Cavitary disease and bilateral lesions are among the risk factors for poor outcome of pulmonary tuberculosis (TB). Our aim was to explore the value and limits of surgery in patients with advanced TB. METHODS: A retrospective study of 57 consecutive patients who underwent thoracic surgery for culture-positive bilateral cavitary pulmonary TB was performed. Forty-four (77.2%) patients were men and 13 (22.8%) patients were women; their ages were in the range of 18-61 years...
October 10, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29037298/determinants-of-multidrug-resistance-among-previously-treated-tuberculosis-patients-in-zimbabwe-2014
#8
G Muchena, G Shambira, N Masuka, T Juru, N Gombe, L Takundwa, D Bangure, M Tshimanga
SETTING: Zimbabwe. OBJECTIVE: To investigate the determinants of multidrug-resistant tuberculosis (MDR-TB) among previously treated TB patients. DESIGN: A 1:3 case-control study with bivariate analysis and logistic regression. RESULTS: Risk factors for MDR-TB were history of nursing an MDR-TB patient (adjusted OR [aOR] 4.46, 95%CI 2.02-9.88), history of hospitalisation for 3 days (aOR 2.91, 95%CI 1.62-5.23) and history of foreign travel and stay outside Zimbabwe (aOR 2...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29037291/the-devil-we-know-is-the-use-of-injectable-agents-for-the-treatment-of-mdr-tb-justified
#9
A Reuter, P Tisile, D von Delft, H Cox, V Cox, L Ditiu, A Garcia-Prats, S Koenig, E Lessem, R Nathavitharana, J A Seddon, J Stillo, A von Delft, J Furin
For decades, second-line injectable agents (IAs) have been the cornerstone of treatment for multidrug-resistant tuberculosis (MDR-TB). Although evidence on the efficacy of IAs is limited, there is an expanding body of evidence on the serious adverse events caused by these drugs. Here, we present the results of a structured literature review of the safety and efficacy of IAs. We review the continued widespread use of these agents in the context of therapeutic alternatives-most notably the newer TB drugs, bedaquiline and delamanid-and from the context of human rights, ethics and patient-centered care...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29033301/characterization-of-gyra-and-gyrb-mutations-associated-with-fluoroquinolone-resistance-in-mycobacterium-tuberculosis-isolates-from-morocco
#10
Imane Chaoui, Amal Oudghiri, Mohammed El Mzibri
BACKGROUND: Fluoroquinolones (FQs) are the cornerstone for treatment of drug-resistant TB, there are the most effective second-line anti-mycobacterial drugs and are recommended for the treatment of MDR-TB. However, it's widely accepted that FQs resistance is high among MDR-TB. Thus, characterization of mutations conferring resistance to FQs will be of a great interest for an effective and efficient management of TB resistance in Morocco. METHODS: A laboratory collection of 30 MTB isolates already characterized as phenotypically and genotypically MDR and 20 pan-susceptible isolates randomly selected were enrolled in this retrospective study...
October 12, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/29031637/molecular-epidemiology-of-multi-and-extensively-drug-resistant-mycobacterium-tuberculosis-in-ireland-2001-2014
#11
E Roycroft, R F O'Toole, M M Fitzgibbon, L Montgomery, M O'Meara, P Downes, S Jackson, J O'Donnell, I F Laurenson, A M McLaughlin, J Keane, T R Rogers
OBJECTIVES: The primary objective of this work was to examine the acquisition and spread of multi-drug resistant (MDR) tuberculosis (TB) in Ireland. METHODS: All available Mycobacterium tuberculosis complex (MTBC) isolates (n = 42), from MDR-TB cases diagnosed in Ireland between 2001 and 2014, were analysed using phenotypic drug-susceptibility testing, Mycobacterial-Interspersed-Repetitive-Units Variable-Number Tandem-Repeat (MIRU-VNTR) genotyping, and whole-genome sequencing (WGS)...
October 12, 2017: Journal of Infection
https://www.readbyqxmd.com/read/29028228/preventing-emergence-of-drug-resistant-tuberculosis-in-myanmar-s-transitioning-health-system
#12
Mishal S Khan, Coll Hutchison, Richard J Coker, Joanne Yoong, Khaung M Hane, Anh L Innes, Tin M Khaing, Sithu Aung
Multidrug-resistant tuberculosis (MDR-TB) is a particular threat to the populations of resource-limited countries. Although inadequate treatment of TB has been identified as a major underlying cause of drug resistance, essential information to inform changes in health service delivery and policy is missing. We investigate factors that may be driving the emergence of MDR-TB in Myanmar, a country where investment and health system reforms are ongoing to address the unexplained, high occurrence of MDR-TB. We conducted a multi-centre, retrospective case-control study in 10 townships across Yangon...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29028223/are-scientific-research-outputs-aligned-with-national-policy-makers-priorities-a-case-study-of-tuberculosis-in-cambodia
#13
Lydia Boudarene, Richard James, Richard Coker, Mishal S Khan
With funding for tuberculosis (TB) research decreasing, and the high global disease burden persisting, there are calls for increased investment in TB research. However, justification of such investments is questionable, when translation of research outputs into policy and health care improvements remains a challenge for TB and other diseases. Using TB in Cambodia as a case study, we investigate how evidence needs of national policy makers are addressed by topics covered in research publications. We first conducted a systematic review to compile all studies on TB in Cambodia published since 2000...
October 1, 2017: Health Policy and Planning
https://www.readbyqxmd.com/read/29027495/monitoring-and-managing-antibiotic-resistance-in-refugee-children
#14
Helena C Maltezou, Dana Elhadad, Daniel Glikman
The past decade the Middle East and Southeastern Europe have witnessed an enormous movement of refugees due to the Syrian war and conflicts in Asia and Africa. Although carriage of and infections with multi-drug resistant (MDR) pathogens in refugees have been reported, pediatric data are scarce. Areas covered: MDR bacterial carriage and infections, and MDR-tuberculosis (TB) in refugee children from 2010. Expert commentary: High MDR carriage rates in refugee children are attributed to high pre-civil war MDR rates, war-damaged infrastructure and healthcare systems, and poor hygiene conditions...
October 13, 2017: Expert Review of Anti-infective Therapy
https://www.readbyqxmd.com/read/29025487/incorporating-social-justice-and-stigma-in-cost-effectiveness-analysis-drug-resistant-tuberculosis-treatment
#15
A Zwerling, D Dowdy, A von Delft, H Taylor, M W Merritt
Novel therapies for multidrug-resistant tuberculosis (MDR-TB) are likely to be expensive. The cost of novel drugs (e.g., bedaquiline, delamanid) may be so prohibitively high that a traditional cost-effectiveness analysis (CEA) would rate regimens containing these drugs as not cost-effective. Traditional CEA may not appropriately account for considerations of social justice, and may put the most disadvantaged populations at greater risk. Using the example of novel drug regimens for MDR-TB, we propose a novel methodology, 'justice-enhanced CEA', and demonstrate how such an approach can simultaneously assess social justice impacts alongside traditional cost-effectiveness ratios...
November 1, 2017: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29017248/fluoroquinolone-resistance-mutation-detection-is-equivalent-to-culture-based-drug-sensitivity-testing-for-predicting-multidrug-resistant-tuberculosis-treatment-outcome-a-retrospective-cohort-study
#16
Maha R Farhat, Karen R Jacobson, Molly F Franke, Devinder Kaur, Megan Murray, Carole D Mitnick
Background: Molecular diagnostics that rapidly and accurately predict fluoroquinolone (FQ) resistance promise to improve treatment outcomes for individuals with multidrug-resistant (MDR) tuberculosis (TB). Mutations in the gyr genes, though, can cause variable levels of in vitro FQ resistance, and some in vitro resistance remains unexplained by gyr mutations alone, but the implications of these discrepancies for treatment outcome are unknown. Methods: We performed a retrospective cohort study of 172 subjects with MDR/extensively drug-resistant TB subjects and sequenced the full gyrA and gyrB open reading frames in their respective sputum TB isolates...
October 15, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29016684/performance-of-the-xpert-mtb-rif-assay-for-the-diagnosis-of-pulmonary-tuberculosis-and-rifampin-resistance-in-a-low-incidence-high-resource-setting
#17
Jason P Rice, Marva Seifert, Kathleen S Moser, Timothy C Rodwell
Performance of the Xpert MTB/RIF assay, designed to simultaneously detect Mycobacterium tuberculosis complex (MTBC) and rifampin (RIF) resistance, has been well documented in low-resource settings with high TB-incidence. However, few studies have assessed its accuracy in low TB incidence settings. We evaluated the performance of Xpert MTB/RIF using clinical sputum specimens routinely collected from suspect pulmonary TB patients over a 4-year time period in San Diego County, California. Xpert MTB/RIF results were compared to acid-fast bacilli (AFB) smear microscopy, mycobacterial culture, and phenotypic drug susceptibility testing (DST)...
2017: PloS One
https://www.readbyqxmd.com/read/29016283/identification-of-risk-factors-of-multidrug-resistant-tuberculosis-by-using-classification-tree-method
#18
Dixin Tan, Bin Wang, Xuhui Li, Xiaonan Cai, Dandan Zhang, Mengyu Li, Cong Tang, Yaqiong Yan, Songlin Yu, Qian Chu, Yihua Xu
Multidrug-resistant tuberculosis (MDR-TB) has become a major public health problem. We tried to apply the classification tree model in building and evaluating a risk prediction model for MDR-TB. In this case-control study, 74 newly diagnosed MDR-TB patients served as the case group, and 95 patients without TB from the same medical institution served as the control group. The classification tree model was built using Chi-square Automatic Interaction Detectormethod and evaluated by income diagram, index map, risk statistic, and the area under receiver operating characteristic (ROC) curve...
September 25, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/28993300/analysis-of-isoniazid-and-rifampicin-resistance-in-mycobacterium-tuberculosis-isolates-in-morocco-using-genotype-mtbdrplus-assay
#19
Wifak Ennassiri, Sanae Jaouhari, Radia Sabouni, Wafa Cherki, Reda Charof, Abdelkarim Filali-Maltouf, Ouafae Lahlou
OBJECTIVES: The number of multidrug-resistant tuberculosis (MDR-TB) cases is rising worldwide. The present investigation aims to evaluate, using the GenoType(®) MTBDRplus, the most common mutations associated with rifampicin (RMP) and isoniazid (INH) resistance within the resistant strains in Morocco. METHODS: 319M. tuberculosis isolates referred to the National Tuberculosis Reference Laboratory, between 2013 and 2015, were subjected to GenoType(®) MTBDRplus for detecting M...
October 6, 2017: Journal of Global Antimicrobial Resistance
https://www.readbyqxmd.com/read/28992819/tb-pcr-and-drug-resistance-pattern-in-balf-in-smear-negative-active-pulmonary-tb
#20
K Chavalertsakul, V Boonsarngsuk, S Saengsri, P Santanirand
<h2>SETTING:</h2>A tertiary referral hospital in Bangkok, Thailand.<h2>OBJECTIVES:</h2>To evaluate the efficacy of a bronchoalveolar lavage fluid (BALF) tuberculosis (TB) polymerase chain reaction (PCR) assay for the diagnosis of sputum smear-negative pulmonary TB (PTB) and the usefulness of a drug-resistant (DR) TB-PCR assay compared with standard drug susceptibility testing (DST).<h2>DESIGN:</h2>BALF samples from 918 patients with acid-fast bacilli (AFB) negative sputum smears who underwent bronchoscopy for diagnostic evaluations of pulmonary diseases were prospectively determined for specific genetic elements of TB using the Anyplex(TM) MTB/NTM Real-Time Detection kit...
October 9, 2017: International Journal of Tuberculosis and Lung Disease
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