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MDR Tuberculosis

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https://www.readbyqxmd.com/read/29244096/treatment-of-pulmonary-tuberculosis-past-and-present
#1
Dmitry Borisovich Giller, Boris Dmitrievich Giller, Galina Vitalievna Giller, Galina Vladimirovna Shcherbakova, Anuar Bahtibaevich Bizhanov, Inga Igorevna Enilenis, Aleksey Aleksandrovich Glotov
OBJECTIVES: Surgical interventional has been key in the treatment of tuberculosis (TB) for a long time. Its importance diminished after the emergence of chemotherapy. However, the spread of rapid multidrug-resistant (MDR) and extensively drug-resistant (XDR) TB has led us to return to surgery to treat TB. Today, every second patient in Russia with destructive TB has either MDR or XDR TB, which is the reason for the low efficacy of conservative treatment. In 2015, treatment with drugs resulted in clinical recovery in only 29...
December 12, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/29243578/design-synthesis-and-in-vitro-anti-microbial-evaluation-of-ethylene-propylene-1h-1-2-3-triazole-4-methylene-tethered-isatin-coumarin-hybrids
#2
Xiaohong Jin, Yan Xu, Xuhong Yang, Xiuling Chen, Minghu Wu, Jianguo Guan, Lianshun Feng
A new class of ethylene/propylene-1H-1,2,3-triazole-4-methylene-tethered isatin-coumarin hybrids 8a-j, integrate three anti-tuberculosis pharmacophores coumarin, isatin and 1,2,3-triazole was designed and synthesized. These hybrids were assessed for their in vitro anti-TB activity against MTB H37Rv and MDR-TB, as well as anti-bacterial activity against Gram-positive and Gram-negative strains, and cytotoxicity in VERO cell line. The results showed that all hybrids with acceptable cytotoxicity (CC50: 64-512 μg/mL) exhibited weak to moderate anti-microbial activity...
December 14, 2017: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/29242075/molecular-drug-resistance-profiles-of-mycobacterium-tuberculosis-from-sputum-specimens-using-ion-semiconductor-sequencing
#3
Joonhong Park, Woori Jang, Myungshin Kim, Yonggoo Kim, So Youn Shin, Kuhn Park, Myung Sook Kim, Soyoung Shin
The increasing burden of multidrug resistant (MDR)-TB, defined by resistance to rifampin (RFP) and isoniazid (INH), and extensively drug resistant-TB, defined by MDR-TB with additional resistance to fluoroquinolones (FQs) and more than one second-line injectable drug, is a serious impediment to global TB control. We evaluated the feasibility of full-length gene analysis including inhA, katG, rpoB, pncA, rpsL embB, eis, and gyrA using a semiconductor NGS with the Ion AmpliSeq TB panel to directly analyse 34 sputum specimens confirmed by phenotypic DST: INH, RFP, ethambutol (EMB), pyrazinamide (PZA), amikacin, kanamycin, streptomycin (SM), FQs including ofloxacin, moxifloxacin, and levofloxacin...
December 11, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29238270/treatment-of-latent-tuberculosis-infection
#4
REVIEW
Patrick Tang, James Johnston
The treatment of latent tuberculosis infection (LTBI) is an essential component of tuberculosis (TB) elimination in regions that have a low incidence of TB. However, the decision to treat individuals with LTBI must consider the limitations of current diagnostic tests for LTBI, the risk of developing active TB disease, the potential adverse effects from chemoprophylactic therapy, and the importance of treatment adherence. When an individual has been diagnosed with LTBI and active TB has been ruled out, this is followed by an evaluation of the risks and benefits of LTBI treatment within the context of the regional epidemiology of TB and public health priorities...
2017: Current Treatment Options in Infectious Diseases
https://www.readbyqxmd.com/read/29230326/tuberculosis-treatment-adherence-of-patients-in-kosovo
#5
Shaip Krasniqi, Arianit Jakupi, Armond Daci, Bahri Tigani, Nora Jupolli-Krasniqi, Mimoza Pira, Valbona Zhjeqi, Burim Neziri
Setting: The poor patient adherence in tuberculosis (TB) treatment is considered to be one of the most serious challenges which reflect the decrease of treatment success and emerging of the Multidrug Resistance-TB (MDR-TB). To our knowledge, the data about patients' adherence to anti-TB treatment in our country are missing. Objective: This study was aimed to investigate the anti-TB treatment adherence rate and to identify factors related to eventual nonadherence among Kosovo TB patients...
2017: Tuberculosis Research and Treatment
https://www.readbyqxmd.com/read/29224631/treatment-outcomes-of-rifabutin-containing-regimens-for-rifabutin-sensitive-multidrug-resistant-pulmonary-tuberculosis
#6
Hyun Lee, Soohyun Ahn, Na Young Hwang, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Nam Yong Lee, Won-Jung Koh
OBJECTIVES: The aim of this study was to evaluate whether rifabutin can improve treatment outcomes in patients with rifabutin-sensitive MDR-TB. METHODS: A retrospective cohort study was performed on 76 patients with rifabutin-sensitive MDR-TB who were treated with or without rifabutin between 2006 and 2011. RESULTS: Overall, 75% (57/76) of patients achieved favorable outcomes, including cure (53/76, 70%) and treatment completion (4/76, 5%)...
December 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29219878/community-based-management-of-multiple-drug-resistant-tuberculosis-in-a-tertiary-hospital-in-tanzania-a-best-practice-implementation-project
#7
Isaya Jelly, Micah D J Peters
BACKGROUND: The World Health Organization (WHO) has prioritized collaboration with communities in its 2016 "End TB" implementation strategy. Acknowledging the difficulties that some communities face in gaining access to health facilities due to barriers such as stigma, discrimination, healthcare expenditure, transport and income loss, partnering with communities in the roll-out of community-based TB management activities is vital. AIM: The aim of this project was to make a contribution to promoting evidence-based practice with regards to the community-based management of multidrug-resistant tuberculosis (MDR-TB) at Kibong'oto National Infectious Disease Hospital, Tanzania, and thereby supporting improvements in patient outcomes and resource utilization...
December 2017: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29219243/genetic-polymorphism-of-human-leucocyte-antigen-and-susceptibility-to-multidrug-resistant-and-rifampicin-resistant-tuberculosis-in-han-chinese-from-hubei-province
#8
X Zhou, Q Zhou, Z-F Yang, W-X Li
We determined the high-resolution allele and haplotype frequencies at the human leucocyte antigen (HLA)A, B and DRB1 loci in the Han population of Hubei province, the TB endemic area of Central China, with pulmonary tuberculosis (PTB), and established the relationship between HLA-A, B and DRB1 alleles as well as haplotypes and susceptibility to multidrug-resistant and rifampicin-resistant tuberculosis (MDR/RR-TB). Blood samples were drawn from 174 patients with MDR/RR-TB and 838 patients with drug-susceptible PTB in ethnic Han population from Hubei province (central China)...
December 8, 2017: International Journal of Immunogenetics
https://www.readbyqxmd.com/read/29212699/rapid-microarray-based-detection-of-rifampicin-isoniazid-and-fluoroquinolone-resistance-in-mycobacterium-tuberculosis-using-a-single-cartridge
#9
Juliane Havlicek, Beatrice Dachsel, Peter Slickers, Sönke Andres, Patrick Beckert, Silke Feuerriegel, Stefan Niemann, Matthias Merker, Ines Labugger
Rapid and robust identification of mutations in Mycobacterium tuberculosis complex (MTBC) strains mediating multidrug and extensively drug-resistant (M/XDR) phenotypes is crucial to combat the MDR tuberculosis (TB) epidemic. Currently available molecular TB drug susceptibility tests are either restricted to single targets/drugs (i.e. Xpert MTB/RIF) or aid the risk of cross-contaminations due to the design limitations of the open platform (i.e. line probe assays).With a good understanding of the technical and commercial boundaries we designed a test cartridge with an introduction of dried reagents, based on an oligonucleotide array, which has the ability to identify MTBC strains resistant to isoniazid, rifampicin and the fluoroquinolones...
December 6, 2017: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29210348/mediating-effect-of-repeated-tuberculosis-exposure-on-the-risk-of-transmission-to-household-contacts-of-multidrug-resistant-tuberculosis-patients
#10
Peng Lu, Xiaoyan Ding, Qiao Liu, Wei Lu, Leonardo Martinez, Jiansheng Sun, Feng Lu, Chongqiao Zhong, Hui Jiang, Changdong Miao, Limei Zhu, Haitao Yang
Primary Mycobacterium tuberculosis transmission is an important driver of the global epidemic of resistance to tuberculosis drugs. A few studies have compared tuberculosis infection in contacts of index cases with different drug-resistant profiles, suggesting that contacts of multidrug-resistant (MDR) tuberculosis cases are at higher risk. Repeated tuberculosis exposure in contacts of MDR tuberculosis patients through recurrent tuberculosis may modify this relationship. We compared tuberculosis infection in household contacts of MDR and drug-susceptible (DS) tuberculosis patients from six cities in southeastern China and investigated whether repeated tuberculosis exposure was a mediating factor...
December 4, 2017: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29209302/influence-of-stress-and-antibiotic-resistance-on-cell-length-distribution-in-mycobacterium-tuberculosis-clinical-isolates
#11
Srinivasan Vijay, Dao N Vinh, Hoang T Hai, Vu T N Ha, Vu T M Dung, Tran D Dinh, Hoang N Nhung, Trinh T B Tram, Bree B Aldridge, Nguyen T Hanh, Do D A Thu, Nguyen H Phu, Guy E Thwaites, Nguyen T T Thuong
Mycobacterial cellular variations in growth and division increase heterogeneity in cell length, possibly contributing to cell-to-cell variation in host and antibiotic stress tolerance. This may be one of the factors influencing Mycobacterium tuberculosis persistence to antibiotics. Tuberculosis (TB) is a major public health problem in developing countries, antibiotic persistence, and emergence of antibiotic resistance further complicates this problem. We wanted to investigate the factors influencing cell-length distribution in clinical M...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29203478/limited-effect-of-later-generation-fluoroquinolones-in-the-treatment-of-ofloxacin-resistant-and-moxifloxacin-susceptible-multidrug-resistant-tuberculosis
#12
Hyun Lee, Soohyun Ahn, Na Young Hwang, Kyeongman Jeon, O Jung Kwon, Hee Jae Huh, Nam Yong Lee, Chang-Ki Kim, Won-Jung Koh
Recent data conflict on the clinical efficacy of later-generation fluoroquinolones, such as moxifloxacin or levofloxacin, for the treatment of multidrug-resistant tuberculosis (MDR-TB) that is resistant to ofloxacin but susceptible to moxifloxacin. The purpose of the present study was to evaluate whether later-generation fluoroquinolones can improve treatment outcomes in patients with ofloxacin-resistant/moxifloxacin-susceptible MDR-TB. A retrospective cohort study was performed on 208 patients with moxifloxacin-susceptible MDR-TB who were treated between 2006 and 2011...
December 4, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29201660/operational-aspects-of-bedaquiline-implementation-in-swaziland-report-from-the-field
#13
D Vambe, T Dlamini, J Furin, C Gracia-Edwards, K Keus, K Kunene, A Shabangu, S N Dlamini, W Sikhondze
Bedaquiline (BDQ) has been recommended by the World Health Organization for the treatment of multi-drug-resistant tuberculosis (MDR-TB) since 2013, but experience using the drug in high-burden, lower-income countries is limited and case studies are needed. Swaziland started using BDQ under national TB programme conditions in 2015 in four pilot sites. As of 1 December 2016, 93 patients had been initiated on BDQ, i.e., 19% of MDR-TB patients treated in the country. Swaziland has developed a systematic and efficient model for BDQ introduction in collaboration with several partners...
September 21, 2017: Public Health Action
https://www.readbyqxmd.com/read/29197427/mycobacterium-tuberculosis-complex-drug-resistance-in-a-high-tuberculosis-incidence-area-from-the-who-eastern-mediterranean-region
#14
Noormohamad Mansoori, Masoumeh Douraghi, Ali Akbar Rajabloo, Masoomeh Taziki, Mehdi Yaseri, Farzam Vaziri
PURPOSE: The incidence of tuberculosis (TB) in Golestan province of Iran has been ranked 10th among countries of World Health Organization (WHO) Eastern Mediterranean Region. The province is residence of ethnically heterogeneous groups. However, there are limited data on Mycobacterium tuberculosis drug resistance in this province. The main aim of this study was to determine the resistance profile of M. tuberculosis complex (MTBC) isolates to first-line anti-TB drugs. METHODS: The clinical specimens were collected from 11807 cases diagnosed during this study...
2017: Journal of Pharmacy & Pharmaceutical Sciences: a Publication of the Canadian Society for Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29191227/performance-of-mtbdrplus-assay-in-detecting-multidrug-resistant-tuberculosis-at-hospital-level
#15
Abebaw Kebede, Daniel Demisse, Meazashwork Assefa, Zerihun Getachew, Bazezew Yenew, Yared Tedla, Gobena Ameni
OBJECTIVE: Multidrug-resistant tuberculosis (MDR-TB) case finding progressively increased in Ethiopia mainly as a result of the utilization of World Health Organization (WHO)-endorsed rapid technologies including MTBDRplus assay. However, there is inadequate data on routine testing performance of the MTBDRplus assay. Consequently, the aim of the study was to assess the routine performance of the MTBDRplus assay in detecting MDR-TB at St. Peter's TB Specialized Hospital. RESULTS: The sensitivity and specificity of MTBDRplus in detecting isoniazid (INH) resistance were 96...
December 1, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29188195/comparative-genomic-analysis-of-two-clonally-related-multidrug-resistant-mycobacterium-tuberculosis-by-single-molecule-real-time-sequencing
#16
Kenneth Siu-Sing Leung, Gilman Kit-Hang Siu, Kingsley King-Gee Tam, Sabrina Wai-Chi To, Rahim Rajwani, Pak-Leung Ho, Samson Sai-Yin Wong, Wei W Zhao, Oliver Chiu-Kit Ma, Wing-Cheong Yam
Background: Multidrug-resistant tuberculosis (MDR-TB) is posing a major threat to global TB control. In this study, we focused on two consecutive MDR-TB isolated from the same patient before and after the initiation of anti-TB treatment. To better understand the genomic characteristics of MDR-TB, Single Molecule Real-Time (SMRT) Sequencing and comparative genomic analyses was performed to identify mutations that contributed to the stepwise development of drug resistance and growth fitness in MDR-TB under in vivo challenge of anti-TB drugs...
2017: Frontiers in Cellular and Infection Microbiology
https://www.readbyqxmd.com/read/29186408/a-significant-therapeutic-effect-of-immunoglobulins-administered-alone-or-in-combination-with-conventional-chemotherapy-in-experimental-pulmonary-tuberculosis-caused-by-drug-sensitive-or-drug-resistant-strains
#17
Nesty Olivares, Yadira Rodriguez, Zyanya Lucia Zatarain-Barron, Brenda Marquina, Dulce Mata-Espinosa, Jorge Barrios-Payán, Cristina Parada, Bárbara Moguel, Clara Espitia Pinzón, Iris Estrada, Rogelio Hernandez-Pando
The recommended chemotherapy for drug sensitive tuberculosis (TB) consists of four different antibiotics administrated for 6-months. This long treatment leads to significant compliance problems and consequently to recrudescence of the disease and to the development of multi drug resistant strains (MDR). Thus, new alternatives are needed to shorten or simplify the treatment of TB. Antibodies have therapeutic effects in animal models of TB, so their use as adjuvants in drug sensitive and MDR TB is an interesting alternative...
November 23, 2017: Pathogens and Disease
https://www.readbyqxmd.com/read/29184888/targeting-dna-replication-and-repair-for-the-development-of-novel-therapeutics-against-tuberculosis
#18
REVIEW
Michael A Reiche, Digby F Warner, Valerie Mizrahi
Mycobacterium tuberculosis is the etiological agent of tuberculosis (TB), an infectious disease which results in approximately 10 million incident cases and 1.4 million deaths globally each year, making it the leading cause of mortality from infection. An effective frontline combination chemotherapy exists for TB; however, this regimen requires the administration of four drugs in a 2 month long intensive phase followed by a continuation phase of a further 4 months with two of the original drugs, and is only effective for the treatment of drug-sensitive TB...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/29183553/childhood-multidrug-resistant-tuberculosis-in-the-european-union-and-european-economic-area-an-analysis-of-tuberculosis-surveillance-data-from-2007-to-2015
#19
Csaba Ködmön, Martin van den Boom, Phillip Zucs, Marieke Johanna van der Werf
BackgroundConfirming tuberculosis (TB) in children and obtaining information on drug susceptibility is essential to ensure adequate treatment. We assessed whether there are gaps in diagnosis and treatment of multidrug-resistant (MDR) TB in children in the European Union and European Economic Area (EU/EEA), quantified the burden of MDR TB in children and characterised cases. Methods: We analysed surveillance data from 2007 to 2015 for paediatric cases younger than 15 years. Results: In that period, 26 EU/EEA countries reported 18,826 paediatric TB cases of whom 4,129 (21...
November 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/29182223/tuberculosis-in-poland-in-2015
#20
Maria Korzeniewska-Koseła
AIM OF THE STUDY: To evaluate the main features of TB epidemiology in 2015 in Poland and to compare with the data on the same phenomena in the EU/EEA countries. METHODS: Analysis of case – based data on TB patients from National TB Register, data on anti-TB drug susceptibility testing results in cases notified in 2015, data from National Institute of Public Health- National Institute of Hygiene on cases of tuberculosis as AIDS-defining disease, data from Central Statistical Office on deaths from tuberculosis based on death certificates, data from ECDC report „ European Centre for Disease Prevention and Control/WHO Regional Office for Europe...
2017: Przegla̧d Epidemiologiczny
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