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https://www.readbyqxmd.com/read/28230495/improved-interactive-computer-assisted-approach-for-evaluation-of-ultrastructural-cilia-abnormalities
#1
Josef A Schroeder, Matthias Semmelmann, Heiko Siegmund, Claudia Grafe, Matthias Evert, Christoph Palm
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230487/pathology-goes-3d-exploring-the-potential-of-array-tomography-versus-fib-nanotomography-for-a-cadasil-sample
#2
Irene Wacker, Rasmus R Schröder, Josef A Schroeder
No abstract text is available yet for this article.
January 2017: Ultrastructural Pathology
https://www.readbyqxmd.com/read/28230462/a-nonrandomized-comparison-study-of-self-hypnosis-yoga-and-cognitive-behavioral-therapy-to-reduce-emotional-distress-in-breast-cancer-patients
#3
Isabelle Bragard, Anne-Marie Etienne, Marie-Elisabeth Faymonville, Philippe Coucke, Eric Lifrange, Hélène Schroeder, Aurélie Wagener, Gilles Dupuis, Guy Jerusalem
The authors asked breast cancer (BC) patients to participate in 1 of 3 mind-body interventions (cognitive-behavioral therapy (CBT), yoga, or self-hypnosis) to explore their feasibility, ease of compliance, and impact on the participants' distress, quality of life (QoL), sleep, and mental adjustment. Ninety-nine patients completed an intervention (CBT: n = 10; yoga: n = 21; and self-hypnosis: n = 68). Results showed high feasibility and high compliance. After the interventions, there was no significant effect in the CBT group but significant positive effects on distress in the yoga and self-hypnosis groups, and, also, on QoL, sleep, and mental adjustment in the self-hypnosis group...
April 2017: International Journal of Clinical and Experimental Hypnosis
https://www.readbyqxmd.com/read/28230352/disease-modifying-effects-of-m1-muscarinic-acetylcholine-receptor-activation-in-an-alzheimer-s-disease-mouse-model
#4
Evan P Lebois, Jason P Schroeder, Thomas J Esparza, Thomas M Bridges, Craig W Lindsley, P Jeffrey Conn, David L Brody, John Scott Daniels, Allan I Levey
Alzheimer's Disease (AD) is the leading cause of dementia worldwide and currently no disease-modifying therapy is available to slow or prevent AD, underscoring the urgent need for neuroprotective therapies. Selective M1 muscarinic acetylcholine receptor (mAChR) activation is an attractive mechanism for AD therapy since M1 mediates key effects on memory, cognition, and behavior and has potential for disease-modifying effects on Aβ formation and tau phosphorylation. To validate M1 as a neuroprotective treatment target for AD, the M1-selective agonist, VU0364572, was chronically dosed to 5XFAD mice from a young age preceding Aβ pathology (2 months) to an age where these mice are known to display memory impairments (6 months)...
February 23, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28226568/design-of-a-spring-assisted-exoskeleton-module-for-wrist-and-hand-rehabilitation
#5
Joel C Perry, Shawn Trimble, Luiz Gustavo Castilho Machado, Jeremiah S Schroeder, Aitor Belloso, Cristina Rodriguez-de-Pablo, Thierry Keller, Joel C Perry, Shawn Trimble, Luiz Gustavo Castilho Machado, Jeremiah S Schroeder, Aitor Belloso, Cristina Rodriguez-de-Pablo, Thierry Keller, Cristina Rodriguez-De-Pablo, Joel C Perry, Jeremiah S Schroeder, Aitor Belloso, Luiz Gustavo Castilho Machado, Thierry Keller, Shawn Trimble
This paper reports on the development of a low-profile exoskeleton module to enable training of the fingers and thumb in grasp and release tasks. The design has been made as an add-on module for use with the ArmAssist arm rehabilitation system (Tecnalia, Spain). Variable-position springs and adjustable link lengths provide adaptability to fit a variety of users. Additive manufacturing has been utilized for the majority of components allowing easy modifications. A few structural components were machined from aluminum or steel to produce a functional prototype with sufficient strength for direct evaluation...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28224342/galactose-%C3%AE-1-3-galactose-atypical-food-allergen-or-model-ige-hypersensitivity
#6
REVIEW
Jeffrey M Wilson, Alexander J Schuyler, Nikhila Schroeder, Thomas A E Platts-Mills
PURPOSE OF REVIEW: Galactose-α-1,3-galactose (α-gal) is a carbohydrate allergen with several unique characteristics. In this article, we discuss some recent advances in our understanding of the 'alpha-gal syndrome,' highlight data supporting the role of ticks in pathogenesis, and speculate on immune mechanisms that lead to sensitization. RECENT FINDINGS: First described as the target of IgE in individuals suffering immediate hypersensitivity reactions to the novel anti-EGF monoclonal antibody cetuximab, it is now clear that α-gal sensitization is associated with mammalian meat allergy as well as reactions to other mammalian products...
January 2017: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/28221176/value-based-insurance-design
#7
Alok D Sharan, Gregory D Schroeder, Michael E West, Alexander R Vaccaro
The increasing awareness of the scarcity of health care resources is forcing the health care industry to improve quality while lowering the cost. One method by which employers and insurance companies are attempting to do this is with value-based insurance design. In these plans, patients pay a lower amount for certain services that are considered high value and a higher amount for services that are considered low value.
February 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28218899/prospective-identification-of-hematopoietic-lineage-choice-by-deep-learning
#8
Felix Buggenthin, Florian Buettner, Philipp S Hoppe, Max Endele, Manuel Kroiss, Michael Strasser, Michael Schwarzfischer, Dirk Loeffler, Konstantinos D Kokkaliaris, Oliver Hilsenbeck, Timm Schroeder, Fabian J Theis, Carsten Marr
Differentiation alters molecular properties of stem and progenitor cells, leading to changes in their shape and movement characteristics. We present a deep neural network that prospectively predicts lineage choice in differentiating primary hematopoietic progenitors using image patches from brightfield microscopy and cellular movement. Surprisingly, lineage choice can be detected up to three generations before conventional molecular markers are observable. Our approach allows identification of cells with differentially expressed lineage-specifying genes without molecular labeling...
February 20, 2017: Nature Methods
https://www.readbyqxmd.com/read/28217764/vpreb-serves-as-an-invariant-surrogate-antigen-for-selecting-immunoglobulin-antigen-binding-sites
#9
Mohamed Khass, Tessa Blackburn, Peter D Burrows, Mark R Walter, Emidio Capriotti, Harry W Schroeder
Developmental checkpoints eliminate B cells synthesizing defective immunoglobulin heavy (HC) and light (LC) chains. The first checkpoint tests for formation of a VpreB/λ5/µHC-containing preB-cell receptor (preBCR) and predicts whether µHCs will bind conventional LCs to form membrane IgM. VpreB and λ5 also create a sensing site that interacts with µHC antigen-binding region CDR-H3, but whether it plays a role in immunoglobulin repertoire selection and function is unknown. On a position-by-position basis, we analyzed the amino acid content of CDR-H3s from H chains cloned from living and apoptotic preB cells and from IgG:Antigen structures...
July 14, 2016: Science Immunology
https://www.readbyqxmd.com/read/28216689/prevalence-of-maedi-visna-in-saskatchewan-sheep
#10
Rhonda Heinrichs, Wendy Wilkins, Gordon Schroeder, John Campbell
A study was conducted to estimate flock and individual seroprevalence of Maedi-visna in Saskatchewan and evaluate risk factors for seropositive flocks. Thirty-five percent (24/68) of flocks and 4.6% (93/2010) of individual samples were positive. Within-flock prevalence ranged from 3.3% to 96.7%. Significant flock-level predictors of flock prevalence included large flock size, purchasing > 50 sheep and respiratory problems in the previous 5 years.
February 2017: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/28214640/the-art-of-mimicry-anterior-clinoid-dural-based-cavernous-hemangioma-mistaken-for-a-meningioma
#11
Tarek R Mansour, Yacine Medhkour, Pouya Entezami, Robert Mrak, Jason Schroeder, Azedine Medhkour
BACKGROUND: Cavernous hemangiomas account for 5-13% of central nervous system vascular lesions. They are usually found intra-axially but rarely involve extra-axial structures, most commonly the middle cranial fossa. A cavernous hemangioma presenting as a clinoid meningioma is extremely rare. CASE DESCRIPTION: We present a 36-year-old male with an asymptomatic intracranial mass found incidentally after an ATV accident. Preoperative MRI revealed a well-defined dural-based lesion arising from the right anterior clinoid process which was nearly homogenously enhancing, with a radiological diagnosis of meningioma...
February 15, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28213527/advancing-viral-rna-structure-prediction-measuring-the-thermodynamics-of-pyrimidine-rich-internal-loops
#12
Andy Phan, Katherine Mailey, Jessica Sakai, Xiaobo Gu, Susan J Schroeder
Accurate thermodynamic parameters improve RNA structure predictions and thus accelerate understanding of RNA function and the identification of RNA drug binding sites. Many viral RNA structures, such as internal ribosome entry sites, have internal loops and bulges that are potential drug target sites. Current models used to predict internal loops are biased towards small, symmetric purine loops, and thus poorly predict asymmetric, pyrimidine-rich loops with more than 6 nucleotides that occur frequently in viral RNA...
February 17, 2017: RNA
https://www.readbyqxmd.com/read/28211131/congenital-diaphragmatic-hernia-outcomes-of-neonates-treated-at-mayo-clinic-with-and-without-extracorporeal-membrane-oxygenation
#13
Katarina Bojanić, Jason M Woodbury, Alexandre N Cavalcante, Ruža Grizelj, Garth F Asay, Christopher E Colby, William A Carey, Gregory J Schears, Toby N Weingarten, Darrell R Schroeder, Juraj Sprung
BACKGROUND: Congenital diaphragmatic hernia (CDH) is a rare anomaly with high mortality and long-term comorbid conditions. AIMS: Our aim was to describe the presenting characteristics, treatment, and outcomes of consecutive patients with CDH treated at our institution. METHODS: We performed a retrospective cohort study and identified consecutive neonates treated for CDH from 2001 to 2015 at our institution. For all patients identified, we reviewed hospital and postdischarge data for neonatal, disease, and treatment characteristics...
March 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/28207657/3-tesla-kinematic-mri-of-the-cervical-spine-for-evaluation-of-adjacent-level-disease-after-monosegmental-anterior-cervical-discectomy-and-arthroplasty-results-of-2-year-follow-up
#14
Steffen K Fleck, Soenke Langner, Christian Rosenstengel, Rebecca Kessler, Marc Matthes, Jan-Uwe Müller, Inga Langner, Sascha Marx, Henry W S Schroeder
STUDY DESIGN: We prospectively evaluated adjacent disc levels after anterior cervical discectomy and arthroplasty (ACDA) using kinematic magnetic resonance imaging (MRI) and plain functional radiographs. OBJECTIVE: ACDA is an established treatment for degenerative cervical disc disease. The objective of this study was to evaluate the use of kinematic MRI for assessing the range of motion (ROM) before and after ACDA compared with plain functional radiographs and to evaluate adjacent degenerative disc disease (aDDD) at mid-term follow-up...
February 15, 2017: Spine
https://www.readbyqxmd.com/read/28207615/value-based-insurance-design
#15
Alok D Sharan, Gregory D Schroeder, Michael E West, Alexander R Vaccaro
The increasing awareness of the scarcity of health care resources is forcing the health care industry to improve quality while lowering the cost. One method by which employers and insurance companies are attempting to do this is with value-based insurance design. In these plans, patients pay a lower amount for certain services that are considered high value and a higher amount for services that are considered low value.
March 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28205593/imaging-cardiac-scn5a-using-the-novel-f-18-radiotracer-radiocaine
#16
Jacob M Hooker, Martin G Strebl, Frederick A Schroeder, Hsiao-Ying Wey, Amrut V Ambardekar, Timothy A McKinsey, Matthias Schoenberger
The key function of the heart, a well-orchestrated series of contractions, is controlled by cardiac action potentials. These action potentials are initiated and propagated by a single isoform of voltage gated sodium channels - SCN5A. However, linking changes in SCN5A expression levels to human disease in vivo has not yet been possible. Radiocaine, an F-18 radiotracer for positron emission tomography (PET), is the first SCN5A imaging agent in the heart. Explants from healthy and failing human hearts were compared using radiocaine autoradiography to determine that the failing heart has ~30% lower SCN5A levels - the first evidence of changes in SCN5A expression in humans as a function of disease...
February 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28199450/association-between-smoking-status-preoperative-exhaled-carbon-monoxide-levels-and-postoperative-surgical-site-infection-in-patients-undergoing-elective-surgery
#17
Margaret B Nolan, David P Martin, Rodney Thompson, Darrell R Schroeder, Andrew C Hanson, David O Warner
Importance: Cigarette smoking is a risk factor for many perioperative complications, including surgical site infection (SSI). The duration of abstinence from smoking required to reduce this risk is unknown. Objectives: To evaluate if abstinence from smoking on the day of surgery is associated with a decreased frequency of SSI in patients who smoke cigarettes and to confirm that smoking is significantly independently associated with SSI when adjustment is made for potentially relevant covariates, such as body mass index...
February 15, 2017: JAMA Surgery
https://www.readbyqxmd.com/read/28196123/correction-cerebral-hemodynamics-in-patients-with-hemolytic-uremic-syndrome-assessed-by-susceptibility-weighted-imaging-and-four-dimensional-non-contrast-mr-angiography
#18
Ulrike Löbel, Nils Daniel Forkert, Peter Schmitt, Thorsten Dohrmann, Maria Schroeder, Tim Magnus, Stefan Kluge, Christina Weiler-Normann, Xiaoming Bi, Jens Fiehler, Jan Sedlacik
[This corrects the article DOI: 10.1371/journal.pone.0164863.].
2017: PloS One
https://www.readbyqxmd.com/read/28196064/mt4-mmp-and-egfr-expression-levels-are-key-biomarkers-for-breast-cancer-patient-response-to-chemotherapy-and-erlotinib
#19
Cassandre Yip, Pierre Foidart, Joan Somja, Alice Truong, Mehdi Lienard, Emilie Feyereisen, Hélène Schroeder, Stéphanie Gofflot, Anne-Françoise Donneau, Joëlle Collignon, Philippe Delvenne, Nor Eddine Sounni, Guy Jerusalem, Agnès Noël
BACKGROUND: Triple-negative breast cancers (TNBC) are heterogeneous cancers with poor prognosis. We aimed to determine the clinical relevance of membrane type-4 matrix metalloproteinase (MT4-MMP), a membrane type matrix metalloproteinase that interacts with epidermal growth factor receptor (EGFR) overexpressed in >50% of TNBC. METHODS: We conducted a retrospective immunohistochemical analysis on human TNBC samples (n=81) and validated our findings in in vitro and in vivo assays...
February 14, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28196031/smoking-increases-the-rate-of-reoperation-for-infection-within-90-days-after-primary-total-joint-arthroplasty
#20
Eric H Tischler, Laura Matsen Ko, Antonia F Chen, Mitchell G Maltenfort, Jacob Schroeder, Matthew S Austin
BACKGROUND: The relationship between smoking and complications after total joint arthroplasty is unclear. Prior studies have been limited by relatively small sample sizes or investigation of select cohorts. The purpose of this study was to investigate the association between smoking and readmission and/or reoperation within 90 days of total joint arthroplasty in a large, non-select cohort of patients. METHODS: Using our institutional database, we retrospectively identified patients who underwent primary total joint arthroplasty between 2000 and 2014...
February 15, 2017: Journal of Bone and Joint Surgery. American Volume
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