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JOURNAL ARTICLE
Soo Heon Kwak, Ryan B Hernandez-Cancela, Daniel A DiCorpo, David E Condon, Jordi Merino, Peitao Wu, Jennifer A Brody, Jie Yao, Xiuqing Guo, Fariba Ahmadizar, Mariah Meyer, Murat Sincan, Josep M Mercader, Sujin Lee, Jeffrey Haessler, Ha My T Vy, Zhaotong Lin, Nicole D Armstrong, Shaopeng Gu, Noah L Tsao, Leslie A Lange, Ningyuan Wang, Kerri L Wiggins, Stella Trompet, Simin Liu, Ruth J F Loos, Renae Judy, Philip H Schroeder, Natalie R Hasbani, Maxime M Bos, Alanna C Morrison, Rebecca D Jackson, Alexander P Reiner, JoAnn E Manson, Ninad S Chaudhary, Lynn K Carmichael, Yii-Der Ida Chen, Kent D Taylor, Mohsen Ghanbari, Joyce van Meurs, Achilleas N Pitsillides, Bruce M Psaty, Raymond Noordam, Ron Do, Kyong Soo Park, J Wouter Jukema, Maryam Kavousi, Adolfo Correa, Stephen S Rich, Scott M Damrauer, Catherine Hajek, Nam H Cho, Marguerite R Irvin, James S Pankow, Girish N Nadkarni, Robert Sladek, Mark O Goodarzi, Jose C Florez, Daniel I Chasman, Susan R Heckbert, Charles Kooperberg, Josée Dupuis, Rajeev Malhotra, Paul S de Vries, Ching-Ti Liu, Jerome I Rotter, James B Meigs
OBJECTIVE: To identify genetic risk factors for incident cardiovascular disease (CVD) among people with type 2 diabetes (T2D). RESEARCH DESIGN AND METHODS: We conducted a multiancestry time-to-event genome-wide association study for incident CVD among people with T2D. We also tested 204 known coronary artery disease (CAD) variants for association with incident CVD. RESULTS: Among 49,230 participants with T2D, 8,956 had incident CVD events (event rate 18...
April 23, 2024: Diabetes Care
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JOURNAL ARTICLE
Jonathan H Ryder, Jenna Preusker, Jeremy Tigh, Muhammad Salman Ashraf, Danny Schroeder, Trevor C Van Schooneveld
No abstract text is available yet for this article.
April 2024: Open Forum Infectious Diseases
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JOURNAL ARTICLE
Amarins N Heeringa
This dataset was collected to study the functional consequences of age-related hearing loss for the auditory nerve, which carries acoustic information from the periphery to the central auditory system. Using high-impedance glass electrodes, raw voltage traces and spike times were recorded from more than one thousand single fibres of the auditory nerve of young-adult, middle-aged, and old Mongolian gerbils raised in a quiet environment. The dataset contains not only responses to simple acoustic stimuli to characterize the fibres, but also to more complex stimuli, such as speech logatomes in background noise and Schroeder-phase stimuli...
April 22, 2024: Scientific Data
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JOURNAL ARTICLE
Chih-Yen Kuo, Rebecca J Tay, Hung-Che Lin, Sheng-Chian Juan, Guillermo Vidal-Diez de Ulzurrun, Yu-Chu Chang, Jason Hoki, Frank C Schroeder, Yen-Ping Hsueh
The ability to sense prey-derived cues is essential for predatory lifestyles. Under low-nutrient conditions, Arthrobotrys oligospora and other nematode-trapping fungi develop dedicated structures for nematode capture when exposed to nematode-derived cues, including a conserved family of pheromones, the ascarosides. A. oligospora senses ascarosides via conserved MAPK and cAMP-PKA pathways; however, the upstream receptors remain unknown. Here, using genomic, transcriptomic and functional analyses, we identified two families of G protein-coupled receptors (GPCRs) involved in sensing distinct nematode-derived cues...
April 22, 2024: Nature Microbiology
#5
Olivier Fortin, Kelsey Christoffel, Abdullah Shoaib, Charu Venkatesan, Kate Cilli, Jason W Schroeder, Cesar Alves, Rebecca D Ganetzky, Jamie L Fraser
Pyruvate dehydrogenase complex deficiency (PDCD) is a disorder of mitochondrial metabolism that is caused by pathogenic variants in multiple genes, including PDHA1 . Typical neonatal brain imaging findings in PDCD have been described, with a focus on malformative features and chronic encephaloclastic changes. However, fetal brain MRI imaging in confirmed PDCD has not been comprehensively described. We sought to demonstrate the prenatal neurological and systemic manifestations of PDCD determined by comprehensive fetal imaging and genomic sequencing...
April 10, 2024: medRxiv
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JOURNAL ARTICLE
Jeremy C Heard, Yunsoo A Lee, Nicholas D D'Antonio, Rajkishen Narayanan, Mark J Lambrechts, John Bodnar, Caroline Purtill, Joshua D Pezzulo, Dominic Farronato, Pat Fitzgerald, Jose A Canseco, Ian David Kaye, Alan S Hilibrand, Alexander R Vaccaro, Christopher K Kepler, Gregory D Schroeder
OBJECTIVES: To evaluate the (1) 90-day surgical outcomes and (2) 1-year revision rate of robotic versus nonrobotic lumbar fusion surgery. METHODS: Patients >18 years of age who underwent primary lumbar fusion surgery at our institution were identified and propensity-matched in a 1:1 fashion based on robotic assistance during surgery. Patient demographics, surgical characteristics, and surgical outcomes, including 90-day surgical complications and 1-year revisions, were collected...
2024: Journal of Craniovertebral Junction and Spine
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JOURNAL ARTICLE
Jeremy C Heard, Teeto Ezeonu, Yunsoo Lee, Mark J Lambrechts, Rajkishen Narayanan, Nathaniel Kern, Quinn Kirkpatrick, Jonathan Ledesma, John J Mangan, Jose A Canseco, Mark F Kurd, Barrett Woods, Alan S Hilibrand, Alexander R Vaccaro, Christopher K Kepler, Gregory D Schroeder, Ian David Kaye
OBJECTIVE: Determine if herniation morphology based on the Michigan State University (MSU) Classification is associated with differences in (1) patient-reported outcome measures (PROMs) or (2) surgical outcomes after a microdiscectomy. METHODS: Adult patients undergoing single-level microdiscectomy between 2014 - 2021 were identified. Demographics and surgical characteristics were collected through a query search and manual chart review. The MSU classification, which assesses disc herniation laterality (zone A was central, zone B/C was lateral) and degree of extrusion into the central canal (grade 1 was up to 50% of the distance to the intra-facet line, grade >1 was beyond this line), was identified on preoperative MRIs...
April 18, 2024: World Neurosurgery
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JOURNAL ARTICLE
Matthew K Schroeder, Suha Abushamma, Alvin T George, Balakrishna Ravella, John Hickman, Anusha Elumalai, Paul Wise, Maria Zulfiqar, Daniel R Ludwig, Anup Shetty, Satish E Viswanath, Chongliang Luo, Shaji Sebastian, David H Ballard, Parakkal Deepak
BACKGROUND AND AIMS: Perianal fistulizing Crohn's disease (PFCD) is an aggressive phenotype of Crohn's disease defined by frequent relapses and disabling symptoms. A novel consensus classification system was recently outlined by the TOpCLASS consortium that seeks to unify disease severity with patient-centered goals but has not yet been validated. We aimed to apply this to a real-world cohort and identify factors that predict transition between classes over time. METHODS: We identified all patients with PFCD and at least one baseline and one follow-up pelvic (pMRI)...
April 20, 2024: Journal of Crohn's & Colitis
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JOURNAL ARTICLE
Santosh L Saraf, Robert Ward Hagar, Modupe Idowu, Ifeyinwa Osunkwo, Kimberly Cruz, Frans A Kuypers, R Clark Brown, James Geib, Maria D Ribadeneira, Patricia Schroeder, Eric Wu, Sanjeev Forsyth, Patrick F Kelly, Theodosia A Kalfa, Marilyn J Telen
Etavopivat is an investigational, once-daily, oral, selective erythrocyte pyruvate kinase (PKR) activator. A multicenter, randomized, placebo-controlled, double-blind, 3-part, phase 1 study (https://clinicaltrials.gov/study/NCT03815695) was conducted to characterize the safety and clinical activity of etavopivat. Thirty-six patients with sickle cell disease (SCD) were enrolled into 4 cohorts: one single-dose; two multiple ascending doses; one open-label [OL]. In the OL cohort, 15 patients (median age 33.0 [range, 17‒55] years received 400-mg etavopivat once daily for 12 weeks; 14 completed treatment...
April 19, 2024: Blood Advances
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JOURNAL ARTICLE
Ryan Thiermann, Michael Sandler, Gursharan Ahir, John T Sauls, Jeremy Schroeder, Steven Brown, Guillaume Le Treut, Fangwei Si, Dongyang Li, Jue D Wang, Suckjoon Jun
Despite much progress, image processing remains a significant bottleneck for high-throughput analysis of microscopy data. One popular platform for single-cell time-lapse imaging is the mother machine, which enables long-term tracking of microbial cells under precisely controlled growth conditions. While several mother machine image analysis pipelines have been developed in the past several years, adoption by a non-expert audience remains a challenge. To fill this gap, we implemented our own software, MM3, as a plugin for the multidimensional image viewer napari...
April 18, 2024: ELife
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JOURNAL ARTICLE
Taylor Lehmann, Emily Morgan, Emily Sharpe, Jenna Steege, Darrell Schroeder, Sarah Dodd
Background: Breastfeeding has numerous health benefits for patients and their infants. There are inconsistencies in how anesthesia providers care for lactating patients undergoing anesthesia. Providers may be cautious and have patients "pump and dump" instead of following current evidence-based recommendations. Video-based education provides a novel reference for health care providers in their fast-paced work environments. This project evaluated the effectiveness of an online video module and resources accessed at the bedside for anesthesia providers caring for lactating patients...
April 18, 2024: Journal of Women's Health
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JOURNAL ARTICLE
Gerolf Renner, Anne Schroeder, Dieter Irblich
How Does the Kaufman Assessment Battery for Children-II Stand the Test of Clinical Practice? Findings in 7- To 12-Year-Old Children Reliability and validity of the KABC-II were investigated in 646 children aged 7 to 12 years who had been assessed in four social pediatric centers and one pediatric clinic in Germany due to developmental, behavioral, or emotional disorders.The reliability of the global scales Fluid-Crystallized-Index (FCI) and Mental Processing Index (MPI) proved to be very high in all age groups, with values ≥ ...
March 2024: Praxis der Kinderpsychologie und Kinderpsychiatrie
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JOURNAL ARTICLE
Jeremy C Heard, Yunsoo Lee, Teeto Ezeonu, Mark J Lambrechts, Rajkishen Narayanan, Caleb Yeung, Justin Wright, John Paulik, Caroline Purtill, John J Mangan, Mark F Kurd, Ian D Kaye, Jose A Canseco, Alan S Hilibrand, Alexander R Vaccaro, Gregory D Schroeder, Christopher K Kepler
PURPOSE: To determine the impact of poor mental health on patient-reported and surgical outcomes after microdiscectomy. METHODS: Patients ≥ 18 years who underwent a single-level lumbar microdiscectomy from 2014 to 2021 at a single academic institution were retrospectively identified. Patient-reported outcomes (PROMs) were collected at preoperative, three-month, and one-year postoperative time points. PROMs included the Oswestry Disability Index (ODI), Visual Analog Scale Back and Leg (VAS Back and VAS Leg, respectively), and the mental and physical component of the short form-12 survey (MCS and PCS)...
April 17, 2024: European Spine Journal
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JOURNAL ARTICLE
Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Jorinde D Hoogenboom, Stephen R Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A A Miranda, Alina Tanase, Liesbeth C de Wreede, Vinzenz Lange, Alexander H Schmidt, Jürgen Sauter, Joshua A Fein, Yung-Tsi Bolon, Meilun He, Steven G E Marsh, Shahinaz M Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor's Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK cell activation by activating KIR-ligand interactions or minimizing inhibitory KIR-ligand interactions. Alternative classifications intended predicting outcome after alloHCT by donor KIR-haplotypes...
2024: Frontiers in Immunology
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JOURNAL ARTICLE
Dalton Dale Schroeder, Alexander Borsgard, Timothy Lee Rossman, Cory Michael Stewart
INTRODUCTION: Shoulder arthroplasties have been demonstrated to provide reliable pain relief as well as functional benefits. The advent of the reverse shoulder arthroplasty allowed for expanded indications for shoulder replacement. Several studies comparing the outcomes of anatomic and reverse total shoulder arthroplasties have demonstrated decreased range of motion in the reverse arthroplasty cohort, especially in internal rotation. The authors hypothesized that slight modifications to the humeral component of a reverse shoulder arthroplasty could result in increased impingement free range of motion without significant sacrifices to stability...
2024: Journal of shoulder and elbow arthroplasty
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JOURNAL ARTICLE
Darryl Kato, Regina Wai-Yan Choy, Eda Canales, Ryan A Dick, April D Lake, Nathan D Shapiro, Elbert Chin, Jiayao Li, Jennifer R Zhang, Qiaoyin Wu, Roland D Saito, Sammy Metobo, Evangelos Aktoudianakis, Scott D Schroeder, Zheng-Yu Yang, Dylan M Glatt, Scott Balsitis, Lindsay Gamelin, Mei Yu, Guofeng Cheng, William E Delaney, John O Link
Chronic hepatitis B (CHB) virus infection afflicts hundreds of millions of people and causes nearly one million deaths annually. The high levels of circulating viral surface antigen (HBsAg) that characterize CHB may lead to T-cell exhaustion, resulting in an impaired antiviral immune response in the host. Agents that suppress HBsAg could help invigorate immunity toward infected hepatocytes and facilitate a functional cure. A series of dihydropyridoisoquinolizinone (DHQ) inhibitors of human poly(A) polymerases PAPD5/7 were reported to suppress HBsAg in vitro...
April 11, 2024: ACS Medicinal Chemistry Letters
#17
JOURNAL ARTICLE
Nikki Cotterill, Knut Schroeder
The CONfidence app was developed to address an unmet need for access to self-help advice and information for bladder and bowel incontinence. The app was developed by the Bladder and Bowel CONfidence Health Integration Team and Expert Self Care and this paper describes the evolution of this innovation to empower patients and the public with bladder and bowel leakage. The app is intended to provide a proactive approach to continence promotion and not replace formal healthcare. Crucial steps were identified to ensuring this resource was accessible and understandable for the intended audience including: input from national clinical experts and individuals with lived experience to co-produce content, clear definition of scope, technical expertise in app development, clear language avoiding jargon or medical terms, credibility assurance and a strategic plan for dissemination...
April 16, 2024: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
#18
JOURNAL ARTICLE
Jacek Wachowiak, Jacques-Emmanuel Galimard, Arnaud Dalissier, Rawad Rihani, Hawazen AlSaedi, Robert F Wynn, Jean-Hugues Dalle, Régis Peffault de Latour, Petr Sedlacek, Adriana Balduzzi, Thomas Schroeder, Ivana Bodova, Marta Gonzalez Vicent, Bernd Gruhn, Rose-Marie Hamladji, Gergely Krivan, Katharine Patrick, Agnieszka Sobkowiak-Sobierajska, Polina Stepensky, Ali Unal, Persis Amrolia, Antonio Perez Martinez, Fanny Rialland, Mahmoud Aljurf, Antonella Isgro, Amos Toren, Marc Bierings, Selim Corbacioglu, Krzysztof Kałwak
This retrospective study evaluated 35 children (median age 5.2 years; range 0.4-18) with myelofibrosis (MF), including 33 with primary myelofibrosis and 2 with secondary myelofibrosis transplanted from matched sibling donor (MSD) (n = 17) or non-MSD (n = 18) between 2000 and 2022. Conditioning was usually chemotherapy-based (n = 33) and myeloablative (n = 32). Fifteen patients received bone marrow (BM), 14 haematopoietic cells (HC) from peripheral blood (PB), and 6 from cord blood (CB)...
April 16, 2024: Bone Marrow Transplantation
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REVIEW
Michael J Schroeder, Casey T Kraft, Jeffrey E Janis, Monica T Kraft
BACKGROUND: Reported drug allergies are commonly encountered by surgeons and can lead to uncertainty in selecting an appropriate agent due to concerns of associated risks with related and cross-reactive drugs. This uncertainty can ultimately lead to increased infection rates. METHODS: A literature review was conducted in PubMed using a combination of the terms "allergy," "allergic reaction," "anaphylaxis," and "surgery," "surgical," or "operating room" for articles published within the last 10 years...
April 2024: Plastic and Reconstructive Surgery. Global Open
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JOURNAL ARTICLE
Mariam Al-Mutawa, Henry W S Schroeder
BACKGROUND: Primary hemifacial spasm (HFS) is usually caused by arterial compression of the facial nerve at the root exit zone at the brainstem. Rarely, a purely venous compression is seen. However, arachnoid bands strangulating the facial nerve have not been recognized as a cause of hemifacial spasm. OBSERVATIONS: The authors present a case of a 24-year-old female who had experienced HFS for 9 years. Endoscopic inspection of the root exit zone revealed no vascular compression but an arachnoid band strangulating the facial nerve...
April 15, 2024: J Neurosurg Case Lessons
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