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https://www.readbyqxmd.com/read/29143282/hypomethylating-agents-for-treatment-and-prevention-of-relapse-after-allogeneic-blood-stem-cell-transplantation
#1
REVIEW
Thomas Schroeder, Christina Rautenberg, Rainer Haas, Ulrich Germing, Guido Kobbe
Despite the curative potential of allogeneic stem cell transplantation (allo-SCT) in patients with acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS), many patients will relapse. Until recently therapeutic options mainly consisted of palliative care, chemotherapy, donor lymphocyte infusions and second transplantation in selected cases. Still many patients either do not tolerate intensive therapies or do not achieve durable remissions and will finally succumb. Given this unmet medical need the hypomethylating agents (HMA), Azacitidine (Aza) and Decitabine (DAC) have been tested as salvage therapy in patients with myeloid malignancies relapsing after allo-SCT...
November 15, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29136325/primary-graft-dysfunction-after-heart-transplantation-incidence-trends-and-associated-risk-factors
#2
Alina Nicoara, David Ruffin, Mary Cooter, Chetan B Patel, Annemarie Thompson, Jacob Schroeder, Mani A Daneshmand, Adrian F Hernandez, Joseph G Rogers, Mihai V Podgoreanu, Madhav Swaminathan, Adam Kretzer, Mark Stafford-Smith, Carmelo A Milano, Raquel R Bartz
Changes in heart transplant (HT) donor and recipient demographics may influence the incidence of primary graft dysfunction (PGD). We conducted a retrospective study to evaluate PGD incidence, trends, and associated risk factors by analyzing consecutive adult patients who underwent HT between January 2009 and December 2014 at our institution. Patients were categorized as having PGD using the International Society of Heart and Lung Transplantation defined criteria. Variables, including clinical and demographic characteristics of donors and recipients, were selected to assess their independent association with PGD...
November 14, 2017: American Journal of Transplantation
https://www.readbyqxmd.com/read/29133432/locus-coeruleus-ablation-exacerbates-cognitive-deficits-neuropathology-and-lethality-in-p301s-tau-transgenic-mice
#3
Termpanit Chalermpalanupap, Jason P Schroeder, Jacki M Rorabaugh, L Cameron Liles, James J Lah, Allan I Levey, David Weinshenker
The brainstem locus coeruleus (LC) supplies norepinephrine (NE) to the forebrain and degenerates in Alzheimer's disease (AD). Loss of LC neurons is correlated with increased severity of other AD hallmarks including β-amyloid (Aβ) plaques, tau neurofibrillary tangles and cognitive deficits, suggesting that it contributes to the disease progression. Lesions of the LC in amyloid-based transgenic mouse models of AD exacerbate Aβ pathology, neuroinflammation, and cognitive deficits, but it is unknown how the loss of LC neurons affects tau-mediated pathology or behavioral abnormalities...
November 13, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29132057/predictors-of-hemodynamic-derangement-during-intubation-in-the-critically-ill-a-nested-case-control-study-of-hemodynamic-management-part-ii
#4
Nathan J Smischney, Mohamed O Seisa, Katherine J Heise, Robert A Wiegand, Kyle D Busack, Jillian L Deangelis, Theodore O Loftsgard, Darrell R Schroeder, Daniel A Diedrich
PURPOSE: Our primary aim was to identify predictors of immediate hemodynamic decompensation during the peri-intubation period. METHODS: We conducted a nested case-control study of a previously identified cohort of adult patients needing intubation admitted to a medical-surgical ICU during 2013-2014. Hemodynamic derangement was defined as cardiac arrest and/or the development of systolic blood pressure <90mmHg and/or mean arterial pressure <65mmHg 30min following intubation...
October 16, 2017: Journal of Critical Care
https://www.readbyqxmd.com/read/29131149/three-dimensional-map-of-nonhematopoietic-bone-and-bone-marrow-cells-and-molecules
#5
Daniel L Coutu, Konstantinos D Kokkaliaris, Leo Kunz, Timm Schroeder
The bone marrow (BM) microenvironment contains many types of cells and molecules with roles in hematopoiesis, osteogenesis, angiogenesis and metabolism. The spatial distribution of the different bone and BM cell types remains elusive, owing to technical challenges associated with bone imaging. To map nonhematopoietic cells and structures in bone and BM, we performed multicolor 3D imaging of osteoblastic, vascular, perivascular, neuronal and marrow stromal cells, and extracellular-matrix proteins in whole mouse femurs...
November 13, 2017: Nature Biotechnology
https://www.readbyqxmd.com/read/29130838/the-psychology-of-rituals-an-integrative-review-and-process-based-framework
#6
Nicholas M Hobson, Juliana Schroeder, Jane L Risen, Dimitris Xygalatas, Michael Inzlicht
Traditionally, ritual has been studied from broad sociocultural perspectives, with little consideration of the psychological processes at play. Recently, however, psychologists have begun turning their attention to the study of ritual, uncovering the causal mechanisms driving this universal aspect of human behavior. With growing interest in the psychology of ritual, this article provides an organizing framework to understand recent empirical work from social psychology, cognitive science, anthropology, behavioral economics, and neuroscience...
November 1, 2017: Personality and Social Psychology Review
https://www.readbyqxmd.com/read/29124477/correction-to-drug-delivery-from-an-innovative-lama-laba-co-suspension-delivery-technology-fixed-dose-combination-mdi-evidence-of-consistency-robustness-and-reliability
#7
Amber Doty, Jon Schroeder, Kou Vang, Mark Sommerville, Mervin Taylor, Brad Flynn, David Lechuga-Ballesteros, Peter Mack
This article was originally published Online First without open access. After publication it was discovered that the author had ordered open access during the production process. The incorrect license was assigned to this paper due to a technical error.
November 9, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29121891/conference-presentation-to-publication-a-retrospective-study-evaluating-quality-of-abstracts-and-journal-articles-in-medical-education-research
#8
Christopher R Stephenson, Brianna E Vaa, Amy T Wang, Darrell R Schroeder, Thomas J Beckman, Darcy A Reed, Adam P Sawatsky
BACKGROUND: There is little evidence regarding the comparative quality of abstracts and articles in medical education research. The Medical Education Research Study Quality Instrument (MERSQI), which was developed to evaluate the quality of reporting in medical education, has strong validity evidence for content, internal structure, and relationships to other variables. We used the MERSQI to compare the quality of reporting for conference abstracts, journal abstracts, and published articles...
November 9, 2017: BMC Medical Education
https://www.readbyqxmd.com/read/29117789/nlrp3-polymorphisms-and-response-to-interferon-beta-in-multiple-sclerosis-patients
#9
Sunny Malhotra, Melissa Sorosina, Jordi Río, Silvia Peroni, Luciana Midaglia, Luisa M Villar, José C Álvarez-Cermeño, Ina Schroeder, Federica Esposito, Ferdinando Clarelli, Uwe K Zettl, Jeannette Lechner-Scott, Nino Spataro, Arcadi Navarro, Giancarlo Comi, Xavier Montalban, Filippo Martinelli-Boneschi, Manuel Comabella
We aimed to investigate whether NLR family, pyrin domain containing 3 (NLRP3) polymorphisms are associated with the response to interferon-beta (IFNβ) in multiple sclerosis (MS) patients. A total of 14 NLRP3 polymorphisms were genotyped in a cohort of 665 relapsing-remitting MS patients recruited across 5 centers and classified into responders and non-responders according to clinical-radiological criteria after 1 year of IFNβ treatment. A meta-analysis failed to demonstrate significant associations between the response to IFNβ and NLRP3 polymorphisms...
November 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/29116819/double-guide-double-wrist-5f-left-coronary-artery-transradial-percutaneous-coronary-intervention-and-the-x-kiss-technique
#10
Dangoisse Vincent, Schroëder Erwin, Claude Hanet, Antoine Guédès, Pancholy Samir
Percutaneous coronary intervention for bifurcated anatomy, particularly at the proximal left coronary artery site, requires guide catheters (GC) of at least 6 french and preferably larger in diameter. We describe a new trans-radial approach more suitable for small artery size: the simultaneous use of both radial arteries for double cannulation of the LMCA with 5F GC: each GC will target either the LM/LAD or the LM/CX artery (or LM-LAD/LM-LAD-1st diagonal branch) stenoses. The technique successfully was applied to 5 cases...
November 8, 2017: Acute Cardiac Care
https://www.readbyqxmd.com/read/29112374/macroscopic-alignment-and-assembly-of-%C3%AF-conjugated-oligopeptides-using-colloidal-microchannels
#11
Bo Li, Lawrence R Valverde, Fengjiao Zhang, Yuecheng Zhou, Songsong Li, Ying Diao, William L Wilson, Charles M Schroeder
One-dimensional (1-D) supramolecular self-assembly offers a powerful strategy to achieve long-range unidirectional ordering of organic semiconducting materials via noncovalent interactions. Using a hierarchical assembly, electronic and optoelectronic materials can be constructed for applications including organic conducting nanowires, organic field-effect transistors (OFETs), and organic light-emitting devices (OLEDs). Despite recent progress, it remains challenging to precisely align and assemble 1-D structures over large areas in a rapid and straightforward manner...
November 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29111517/copper-ii-and-gold-iii-mediated-cyclization-of-a-thiourea-to-a-substituted-2-aminobenzothiazole
#12
Zachary W Schroeder, L K Hiscock, Louise Nicole Dawe
Benzothiazole derivatives are a class of privileged molecules due to their biological activity and pharmaceutical applications. One route to these molecules is via intramolecular cyclization of thioureas to form substituted 2-aminobenzothiazoles, but this often requires harsh conditions or employs expensive metal catalysts. Herein, the copper(II)- and gold(III)-mediated cyclizations of thioureas to substituted 2-aminobenzothiazoles are reported. The single-crystal X-ray structures of the thiourea N-(3-methoxyphenyl)-N'-(pyridin-2-yl)thiourea, C13H13N3OS, and the intermediate metal complexes aquabis[5-methoxy-N-(pyridin-2-yl-κN)-1,3-benzothiazol-2-amine-κN(3)]copper(II) dinitrate, [Cu(C13H11N3OS)2(H2O)](NO3)2, and bis{2-[(5-methoxy-1,3-benzothiazol-2-yl)amino]pyridin-1-ium} dichloridogold(I) chloride monohydrate, (C13H12N3OS)2[AuCl2]Cl·H2O, are reported...
November 1, 2017: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29110058/the-chain-of-lakes-sign
#13
REVIEW
Jennifer A Schroeder, Raymond B Dyer, Brenda L Holbert
No abstract text is available yet for this article.
November 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29108499/what-barriers-and-facilitators-do-school-nurses-experience-when-implementing-an-obesity-intervention
#14
Krista Schroeder, Arlene Smaldone
A recent evaluation of a school nurse-led obesity intervention demonstrated a 5% implementation rate. The purpose of this study was to explore school nurses' perceived barriers to and facilitators of the intervention in order to understand reasons for the low implementation rate. Methods included semi-structured individual interviews with school nurses. Data were analyzed using content analysis and heat mapping. Nineteen nurses participated and eight themes were identified. Parental and administrative gatekeeping, heavy nurse workload, obesogenic environments, and concerns about obesity stigma were barriers to implementation...
December 2017: Journal of School Nursing: the Official Publication of the National Association of School Nurses
https://www.readbyqxmd.com/read/29108429/sources-of-spontaneous-mutagenesis-in-bacteria
#15
Jeremy W Schroeder, Ponlkrit Yeesin, Lyle A Simmons, Jue D Wang
Mutations in an organism's genome can arise spontaneously, that is, in the absence of exogenous stress and prior to selection. Mutations are often neutral or deleterious to individual fitness but can also provide genetic diversity driving evolution. Mutagenesis in bacteria contributes to the already serious and growing problem of antibiotic resistance. However, the negative impacts of spontaneous mutagenesis on human health are not limited to bacterial antibiotic resistance. Spontaneous mutations also underlie tumorigenesis and evolution of drug resistance...
November 6, 2017: Critical Reviews in Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29106770/probing-the-cardiac-malate-aspartate-shuttle-non-invasively-using-hyperpolarized-1-2-13-c2-pyruvate
#16
Albert P Chen, Angus Z Lau, Yi-Ping Gu, Marie A Schroeder, Jennifer Barry, Charles H Cunningham
Previous studies have demonstrated that using hyperpolarized [2-(13) C]pyruvate as a contrast agent can reveal (13) C signals from metabolites associated with the tricarboxylic acid (TCA) cycle. However, the metabolites detectable from TCA cycle-mediated oxidation of [2-(13) C]pyruvate are the result of several metabolic steps. In the instance of the [5-(13) C]glutamate signal, the amplitude can be modulated by changes to the rates of pyruvate dehydrogenase (PDH) flux, TCA cycle flux and metabolite pool size...
November 6, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/29105342/optimization-and-evaluation-of-antiparasitic-benzamidobenzoic-acids-as-inhibitors-of-kinetoplastid-hexokinase-1
#17
Daniel P Flaherty, Michael T Harris, Chad E Schroeder, Haaris Khan, Elizabeth Kahney, Amber Hackler, Stephen Patrick, Warren S Weiner, Jeffrey Aube, Elizabeth R Sharlow, James C Morris, Jennifer E Golden
Kinetoplastid-based infections are neglected diseases that represent a significant human health issue. Chemotherapeutic options are limited due to toxicity, parasite susceptibility, and poor patient compliance. In response, we studied a molecular target-directed approach involving intervention of hexokinase activity - a pivotal enzyme in parasite metabolism. A benzamidobenzoic acid hit with modest biochemical inhibition of Trypanosoma brucei hexokinase 1 (TbHK1, IC₅₀ = 9.1 μM), low mammalian cytotoxicity (IMR90, EC₅₀ > 25 μM), and no appreciable activity on whole BSF parasites was optimized to afford a probe with improved TbHK1 potency and, significantly, efficacy against whole BSF parasites (TbHK1, IC₅₀ = 0...
November 4, 2017: ChemMedChem
https://www.readbyqxmd.com/read/29105205/enhanced-antigen-presenting-and-t-cell-functions-during-late-phase-allergic-responses-in-the-lung
#18
Mark C Liu, HuiQing Xiao, Linda Breslin, Bruce Bochner, John Schroeder
BACKGROUND: Allergic inflammation is a common feature of asthma and may contribute to both development and perpetuation of disease. The interaction of antigen presenting cells (APC) with sensitized helper T lymphocytes (TC) producing Th2 cytokines may determine the inflammatory response. Recruitment of APC and TC to the lung during allergic responses has been demonstrated, but functional studies in humans have been limited. OBJECTIVE: This study examined the function of APC and TC accumulating at sites of inflammation after segmental allergen challenge (SAC)...
November 3, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29102228/macrocyclic-pyrrolobenzodiazepine-dimers-as-antibody-drug-conjugate-payloads
#19
Andrew F Donnell, Yong Zhang, Erik M Stang, Donna D Wei, Andrew J Tebben, Heidi L Perez, Gretchen M Schroeder, Chin Pan, Chetana Rao, Robert M Borzilleri, Gregory D Vite, Sanjeev Gangwar
Macrocyclic pyrrolobenzodiazepine dimers were designed and evaluated for use as antibody-drug conjugate payloads. Initial structure-activity exploration established that macrocyclization could increase the potency of PBD dimers compared with non-macrocyclic analogs. Further optimization overcame activity-limiting solubility issues, leading to compounds with highly potent (picomolar) activity against several cancer cell lines. High levels of in vitro potency and specificity were demonstrated with an anti-mesothelin conjugate...
October 16, 2017: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29101988/acr-appropriateness-criteria-%C3%A2-penetrating-neck%C3%A2-injury
#20
Jason W Schroeder, Thomas Ptak, Amanda S Corey, Osmanuddin Ahmed, Walter L Biffl, Joseph A Brennan, Ankur Chandra, Michael Ginsburg, Michael Hanley, Christopher H Hunt, Michele M Johnson, Tabassum A Kennedy, Nandini D Patel, Bruno Policeni, Charles Reitman, Michael L Steigner, Shirley I Stiver, Richard Strax, Matthew T Whitehead, Karin E Dill
In patients with penetrating neck injuries with clinical soft injury signs, and patients with hard signs of injury who do not require immediate surgery, CT angiography of the neck is the preferred imaging procedure to evaluate extent of injury. Other modalities, such as radiography and fluoroscopy, catheter-based angiography, ultrasound, and MR angiography have their place in the evaluation of the patient, depending on the specific clinical situation and question at hand. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel...
November 2017: Journal of the American College of Radiology: JACR
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