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emerging and reemerging diseases

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https://www.readbyqxmd.com/read/28291501/lateral-flow-rapid-test-for-accurate-and-early-diagnosis-of-scrub-typhus-a-febrile-illness-of-historically-military-importance-in-the-pacific-rim
#1
Chien-Chung Chao, Zhiwen Zhangm, Giulia Weissenberger, Hua-Wei Chen, Wei-Mei Ching
Scrub typhus (ST) is an infection caused by Orientia tsutsugamushi. Historically, ST was ranked as the second most important arthropod-borne medical problem only behind malaria during World War II and the Vietnam War. The disease occurs mainly in Southeast Asia and has been shown to emerge and reemerge in new areas, implying the increased risk for U.S. military and civilian personnel deployed to these regions. ST can effectively be treated by doxycycline provided the diagnosis is made early, before the development of severe complications...
March 2017: Military Medicine
https://www.readbyqxmd.com/read/28275047/the-new-biology-and-pharmacology-of-glucagon
#2
REVIEW
T D Müller, B Finan, C Clemmensen, R D DiMarchi, M H Tschöp
In the last two decades we have witnessed sizable progress in defining the role of gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the molecular basis of the huge metabolic benefits in bariatric surgery is emerging while novel incretin-based medicines based on endogenous hormones such as glucagon-like peptide 1 and pancreas-derived amylin are improving diabetes management. These and related developments have fostered the discovery of novel insights into endocrine control of systemic metabolism, and in particular a deeper understanding of the importance of communication across vital organs, and specifically the gut-brain-pancreas-liver network...
April 2017: Physiological Reviews
https://www.readbyqxmd.com/read/28207078/emerging-infectious-diseases-animals-and-future-epidemics
#3
Herbert L DuPont
Emerging and reemerging infections have become prevalent in the United States since the 1970s, causing illness, death, and fear among the public. The published literature was reviewed to offer a perspective on risk factors for disease acquisition and to allow a prediction of the next microbial assault after Ebola and Zika. Four well-integrated factors likely will contribute simultaneously: animals colonized or infected by pathogens capable of human transmission, microbes recurrently changing their virulence, a growing number of susceptible people, and climatic and environmental factors encouraging disease transmission...
February 1, 2017: Texas Medicine
https://www.readbyqxmd.com/read/28192064/aedes-borne-virus-mosquito-interactions-mass-spectrometry-strategies-and-findings
#4
Victoria Pando-Robles, Cesar V Batista
Aedes-borne viruses are responsible for high-impact neglected tropical diseases and unpredictable outbreaks such as the ongoing Zika epidemics. Aedes mosquitoes spread different arboviruses such as Dengue virus (DENV), Chikungunya virus (CHIKV), and Zika virus, among others, and are responsible for the continuous emergence and reemergence of these pathogens. These viruses have complex transmission cycles that include two hosts, namely the Aedes mosquito as a vector and susceptible vertebrate hosts. Human infection with arboviruses causes diseases that range from subclinical or mild to febrile diseases, encephalitis, and hemorrhagic fever...
February 13, 2017: Vector Borne and Zoonotic Diseases
https://www.readbyqxmd.com/read/28143444/peritoneal-and-genital-coccidioidomycosis-in-an-otherwise-healthy-danish-female-a-case-report
#5
Ole Bæk, Karen Astvad, Reza Serizawa, Lawrence J Wheat, Pia T Brenøe, Ann-Brit E Hansen
BACKGROUND: Coccidioidomycosis is a fungal infection that usually presents as a primary lung infection. The fungus is endemic to the Southwest United States of America, northern Mexico and parts of Central and South America the infection is rare outside these areas. However, some patients develop disseminated infection that can lie dormant for several years and can present itself in travelers. We report the first case of extra pulmonary Coccidioidomycosis in a non-immunocompromised individual in Denmark...
January 31, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28099652/path-of-infectious-diseases-in-brazil-in-the-last-50-years-an-ongoing-challenge
#6
Eliseu Alves Waldman, Ana Paula Sayuri Sato
In this article, we comment on the main features of infectious diseases in Brazil in the last 50 years, highlighting how much of this path Revista de Saúde Pública could portray. From 1967 to 2016, 1,335 articles focusing on infectious diseases were published in Revista de Saúde Pública. Although the proportion of articles on the topic have decreased from about 50.0% to 15.0%, its notability remained and reflected the growing complexity of the research required for its control. It is noteworthy that studies design and analysis strategies progressively became more sophisticated, following the great development of epidemiology in Brazil in the recent decades...
December 22, 2016: Revista de Saúde Pública
https://www.readbyqxmd.com/read/28097318/emerging-and-reemerging-infectious-diseases-the-dichotomy-between-acute-outbreaks-and-chronic-endemicity
#7
Catharine I Paules, Anthony S Fauci
No abstract text is available yet for this article.
February 21, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28095455/novel-porcine-epidemic-diarrhea-virus-pedv-variants-with-large-deletions-in-the-spike-s-gene-coexist-with-pedv-strains-possessing-an-intact-s-gene-in-domestic-pigs-in-japan-a-new-disease-situation
#8
Nguyen Van Diep, Junzo Norimine, Masuo Sueyoshi, Nguyen Thi Lan, Ryoji Yamaguchi
Since late 2013, after an absence of seven years, outbreaks of porcine epidemic diarrhea virus (PEDV) infection have reemerged and swept rapidly across Japan, resulting in significant economic losses. In this study, we report the emergence, mixed infection, and genetic characterization of 15 novel field PEDV variants with large genomic deletions. The sizes of deletion varied between 582 nt (194 aa) and 648 nt (216 aa) at positions 28-714 (10-238) on the S gene (protein). Among 17 PEDV samples isolated from individual pigs, all of them contained at least two distinct genotypes with large genomic deletions, and 94...
2017: PloS One
https://www.readbyqxmd.com/read/28092259/-first-case-of-chikungunya-fever-in-hermosillo-sonora-mexico
#9
Miguel Ángel Martínez-Medina, Ismael Antonio Cañedo-Dorame
The Chikungunya is an arbovirus first described during a 1952 outbreak of febrile exantematic disease in southern Tanganyika (now Tanzania). It is a virus within the alphavirus genus of the Togaviridae family, it is usually transmitted to humans by Aedes mosquitoes. Typically, the disease manifests as acute onset of fever and joint pains. This study describes the clinical characteristics the first imported case infected with chikungunya fever (CHIK) in Hermosillo, Sonora, Mexico. We report the case of a 30 years old man seen in our emergency department due to fever, polyarthralgia, rash and headache...
January 2017: Revista Médica del Instituto Mexicano del Seguro Social
https://www.readbyqxmd.com/read/28076445/emerging-bordetella-pertussis-strains-induce-enhanced-signaling-of-human-pattern-recognition-receptors-tlr2-nod2-and-secretion-of-il-10-by-dendritic-cells
#10
Elise S Hovingh, Marjolein van Gent, Hendrik-Jan Hamstra, Marc Demkes, Frits R Mooi, Elena Pinelli
Vaccines against pertussis have been available for more than 60 years. Nonetheless, this highly contagious disease is reemerging even in countries with high vaccination coverage. Genetic changes of Bordetella pertussis over time have been suggested to contribute to the resurgence of pertussis, as these changes may favor escape from vaccine-induced immunity. Nonetheless, studies on the effects of these bacterial changes on the immune response are limited. Here, we characterize innate immune recognition and activation by a collection of genetically diverse B...
2017: PloS One
https://www.readbyqxmd.com/read/28004307/the-potential-of-social-media-and-internet-based-data-in-preventing-and-fighting-infectious-diseases-from-internet-to-twitter
#11
Khaled Al-Surimi, Mohammed Khalifa, Salwa Bahkali, Ashraf El-Metwally, Mowafa Househ
Health threats due to infectious diseases used to be a major public health concerns around the globe till mid of twentieth century when effective public health interventions helped in eradicating a number of infectious diseases around the world. Over the past 15 years, there has been a rise in the number of emerging and reemerging infectious diseases being reported such as the Acute Respiratory Syndrome (SARS) in 2002, HINI in 2009, Middle East Respiratory Syndrome (MERS) in 2012, Ebola in 2014, and Zika in 2016...
December 22, 2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27983501/a-framework-for-modeling-emerging-diseases-to-inform-management
#12
Robin E Russell, Rachel A Katz, Katherine L D Richgels, Daniel P Walsh, Evan H C Grant
The rapid emergence and reemergence of zoonotic diseases requires the ability to rapidly evaluate and implement optimal management decisions. Actions to control or mitigate the effects of emerging pathogens are commonly delayed because of uncertainty in the estimates and the predicted outcomes of the control tactics. The development of models that describe the best-known information regarding the disease system at the early stages of disease emergence is an essential step for optimal decision-making. Models can predict the potential effects of the pathogen, provide guidance for assessing the likelihood of success of different proposed management actions, quantify the uncertainty surrounding the choice of the optimal decision, and highlight critical areas for immediate research...
January 2017: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/27880753/notes-from-the-field-community-based-prevention-of-rocky-mountain-spotted-fever-sonora-mexico-2016
#13
Anne Straily, Naomi Drexler, Denica Cruz-Loustaunau, Christopher D Paddock, Gerardo Alvarez-Hernandez
Rocky Mountain spotted fever (RMSF), a life-threatening tickborne zoonosis caused by Rickettsia rickettsii, is a reemerging disease in Mexico (1,2). R. rickettsii is an intracellular bacterium that infects vascular endothelium and can cause multisystem organ failure and death in the absence of timely administration of a tetracycline-class antibiotic, typically doxycycline. Epidemic RMSF, as described in parts of Arizona and Mexico, is associated with massive local infestations of the brown dog tick (Rhiphicephalus sanguineus sensu lato) on domestic dogs and in peridomestic settings that result in high rates of human exposure; for example, during 2003-2012, in Arizona the incidence of RMSF in the three most highly affected communities was 150 times the U...
November 25, 2016: MMWR. Morbidity and Mortality Weekly Report
https://www.readbyqxmd.com/read/27869387/-trends-in-pertussis-mortality-and-morbidity-in-colombia-2002-2012
#14
Doris Cardona, María Osley Garzón, Mateo Calle, Maite Catalina Agudelo, Ángela Segura
Whooping cough is a public health problem that mainly affects children under one year of age with highly lethal outcomes. It is a re-emerging disease, which is preventable by immunization. Objective: To analyze mortality and morbidity trends of whooping cough in Colombia between 2002 and 2012. Materials and methods: We conducted a quantitative descriptive study of deaths by pertussis between 2002 and 2012 using data from death certificates registered by the Departamento Administrativo Nacional de Estadística, and cases reported to the Sistema Nacional de Vigilancia en Salud Pública, 2005-2012...
September 1, 2016: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/27720044/temperature-dependent-effects-on-the-replication-and-transmission-of-arthropod-borne-viruses-in-their-insect-hosts
#15
REVIEW
Glady Hazitha Samuel, Zach N Adelman, Kevin M Myles
The transmissibility of vector borne viruses can be affected by a combination of factors, both extrinsic (climatic changes, temperature, urbanization, among others) and intrinsic (genetics, life span, immunity, among others). Temperature is of particular importance since the insect vectors of arthropod-borne viruses (arboviruses) are ectothermic and acutely susceptible to temperature changes. Modeling suggests that with increasing global temperature and urbanization, arboviral diseases will continue to emerge or reemerge...
August 2016: Current Opinion in Insect Science
https://www.readbyqxmd.com/read/27598706/cdc-s-flexible-epidemiologist-a-strategy-for-enhancing-health-department-infectious-disease-epidemiology-capacity
#16
Christina Chung, Leah S Fischer, Angelica OʼConnor, Alvin Shultz
CONTEXT: CDC's Epidemiology and Laboratory Capacity for Infectious Diseases (ELC) Cooperative Agreement aims to help health departments strengthen core epidemiology capacity needed to respond to a variety of emerging infectious diseases. In fiscal year 2014, $6 million was awarded to 41 health departments for flexible epidemiologists (FEs). FEs were intended to help meet health departments' unique needs and support unanticipated events that could require the diversion of resources to specific emerging or reemerging diseases...
September 2, 2016: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/27324390/exosomes-in-viral-disease
#17
REVIEW
Monique R Anderson, Fatah Kashanchi, Steven Jacobson
Viruses have evolved many mechanisms by which to evade and subvert the immune system to ensure survival and persistence. However, for each method undertaken by the immune system for pathogen removal, there is a counteracting mechanism utilized by pathogens. The new and emerging role of microvesicles in immune intercellular communication and function is no different. Viruses across many different families have evolved to insert viral components in exosomes, a subtype of microvesicle, with many varying downstream effects...
July 2016: Neurotherapeutics: the Journal of the American Society for Experimental NeuroTherapeutics
https://www.readbyqxmd.com/read/27284221/loop-mediated-isothermal-amplification-an-innovative-gene-amplification-technique-for-animal-diseases
#18
REVIEW
Pravas Ranjan Sahoo, Kamadev Sethy, Swagat Mohapatra, Debasis Panda
India being a developing country mainly depends on livestock sector for its economy. However, nowadays, there is emergence and reemergence of more transboundary animal diseases. The existing diagnostic techniques are not so quick and with less specificity. To reduce the economy loss, there should be a development of rapid, reliable, robust diagnostic technique, which can work with high degree of sensitivity and specificity. Loop mediated isothermal amplification assay is a rapid gene amplification technique that amplifies nucleic acid under an isothermal condition with a set of designed primers spanning eight distinct sequences of the target...
May 2016: Veterinary World
https://www.readbyqxmd.com/read/27242902/liposomal-systems-as-nanocarriers-for-the-antiviral-agent-ivermectin
#19
Romina Croci, Elisabetta Bottaro, Kitti Wing Ki Chan, Satoru Watanabe, Margherita Pezzullo, Eloise Mastrangelo, Claudio Nastruzzi
RNA virus infections can lead to the onset of severe diseases such as fever with haemorrhage, multiorgan failure, and mortality. The emergence and reemergence of RNA viruses continue to pose a significant public health threat worldwide with particular attention to the increasing incidence of flaviviruses, among others Dengue, West Nile Virus, and Yellow Fever viruses. Development of new and potent antivirals is thus urgently needed. Ivermectin, an already known antihelminthic drug, has shown potent effects in vitro on Flavivirus helicase, with EC50 values in the subnanomolar range for Yellow Fever and submicromolar EC50 for Dengue Fever, Japanese encephalitis, and tick-borne encephalitis viruses...
2016: International Journal of Biomaterials
https://www.readbyqxmd.com/read/27216777/genomic-analysis-of-the-emergence-evolution-and-spread-of-human-respiratory-rna-viruses
#20
Tommy T-Y Lam, Huachen Zhu, Yi Guan, Edward C Holmes
The emergence and reemergence of rapidly evolving RNA viruses-particularly those responsible for respiratory diseases, such as influenza viruses and coronaviruses-pose a significant threat to global health, including the potential of major pandemics. Importantly, recent advances in high-throughput genome sequencing enable researchers to reveal the genomic diversity of these viral pathogens at much lower cost and with much greater precision than they could before. In particular, the genome sequence data generated allow inferences to be made on the molecular basis of viral emergence, evolution, and spread in human populations in real time...
August 31, 2016: Annual Review of Genomics and Human Genetics
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