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Barbara P Sanders, Isabel de Los Rios Oakes, Vladimir van Hoek, Viki Bockstal, Tobias Kamphuis, Taco G Uil, Yutong Song, Gillian Cooper, Laura E Crawt, Javier Martín, Roland Zahn, John Lewis, Eckard Wimmer, Jerome H H V Custers, Hanneke Schuitemaker, Jeronimo Cello, Diana Edo-Matas
The poliovirus vaccine field is moving towards novel vaccination strategies. Withdrawal of the Oral Poliovirus Vaccine and implementation of the conventional Inactivated Poliovirus Vaccine (cIPV) is imminent. Moreover, replacement of the virulent poliovirus strains currently used for cIPV with attenuated strains is preferred. We generated Cold-Adapted Viral Attenuation (CAVA) poliovirus strains by serial passage at low temperature and subsequent genetic engineering, which contain the capsid sequences of cIPV strains combined with a set of mutations identified during cold-adaptation...
March 2016: PLoS Pathogens
Michael Wall, Chris A Johnson, Kimberly E Cello, K D Zamba, Michael P McDermott, John L Keltner
PURPOSE: The Idiopathic Intracranial Hypertension Treatment Trial (IIHTT) showed that acetazolamide provided a modest, significant improvement in mean deviation (MD). Here, we further analyze visual field changes over the 6-month study period. METHODS: Of 165 subjects with mild visual loss in the IIHTT, 125 had perimetry at baseline and 6 months. We evaluated pointwise linear regression of visual sensitivity versus time to classify test locations in the worst MD (study) eye as improving or not; pointwise changes from baseline to month 6 in decibels; and clinical consensus of change from baseline to 6 months...
March 2016: Investigative Ophthalmology & Visual Science
Kimberly E Cello, John L Keltner, Chris A Johnson, Michael Wall
BACKGROUND: To determine the prevalence of visual field (VF) performance failures (PF) and treatment failures (TFs), and identify factors associated with PFs in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). METHODS: A total of 165 participants from 38 sites with idiopathic intracranial hypertension (IIH) and mild visual loss were randomized to either acetazolamide-plus diet or placebo-plus diet. The IIHTT Visual Field Reading Center evaluated 2950 Swedish Interactive Threshold Algorithm Standard 24-2 VFs from the enrolled participants...
March 2016: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
Barbara P Sanders, Ying Liu, Alies Brandjes, Vladimir van Hoek, Isabel de Los Rios Oakes, John Lewis, Eckard Wimmer, Jerome H H V Custers, Hanneke Schuitemaker, Jeronimo Cello, Diana Edo-Matas
Brunenders, a type I poliovirus (PV) strain, was developed in 1952 by J. F. Enders and colleagues through serial in vitro passaging of the parental Brunhilde strain, and was reported to display partial neuroattenuation in monkeys. This phenotype of attenuation encouraged two vaccine manufacturers to adopt Brunenders as the type I component for their inactivated poliovirus vaccines (IPVs) in the 1950s, although today no licensed IPV vaccine contains Brunenders. Here we confirmed, in a transgenic mouse model, the report of Enders on the reduced neurovirulence of Brunenders...
September 2015: Journal of General Virology
Alexander Woywodt
Corrigan's secret door describes a metaphorical escape route for busy physicians. The term was derived from the successful and exceptionally busy professional life of Irish physician Dominic John Corrigan (1802-80). It is claimed that Corrigan's outpatient clinic was so busy that he required a secret door in his consulting rooms to escape from the ever-growing queue of eager patients. The origins of this charming story are unknown, and the door may have never existed. However, at present, Corrigan's secret door is often quoted when busy physicians have their own little ways in surviving a stressful professional life...
October 2010: NDT Plus
John L Keltner, Chris A Johnson, Kimberly E Cello, Michael Wall
PURPOSE: To characterize visual field (VF) loss at the baseline visit and to evaluate VF quality control (QC) procedures in the Idiopathic Intracranial Hypertension Treatment Trial (IIHTT). METHODS: The Visual Field Reading Center (VFRC) evaluated 660 baseline VFs (1320 hemifields) from 165 enrolled patients. Three readers independently classified each superior and inferior hemifield and identified any abnormalities. A subset (20%) of the hemifields was reread to evaluate within- and between-reader agreements...
April 29, 2014: Investigative Ophthalmology & Visual Science
Kimberly M Winges, John S Werner, Danielle J Harvey, Kimberly E Cello, Mary K Durbin, Laura J Balcer, Peter A Calabresi, John L Keltner
BACKGROUND: Patients with multiple sclerosis (MS) demonstrate thinning of peripapillary retinal nerve fiber layer (RNFL) and decreased macular volume as measured by optical coherence tomography (OCT). To our knowledge, there are no previous reports from a large MS OCT database with strict quality control measures that quantitate RNFL and macula in patients with relapsing-remitting multiple sclerosis. METHODS: The University of California Davis OCT Reading Center gathered OCT data at baseline as part of the North American phase 3 trial of fingolimod (Gilenya)...
December 2013: Journal of Neuro-ophthalmology: the Official Journal of the North American Neuro-Ophthalmology Society
John P Cello, Stanley J Rogers
The gastroenterologist, whether in academic or clinical practice, must face the reality that an increasingly large percentage of adult patients are morbidly obese. Morbid obesity is associated with significant morbidity and mortality including enhanced morbidity from cardiovascular, cerebrovascular, hepatobiliary and colonic diseases. Most of these associated diseases are actually preventable. Based on the 1991 NIH consensus conference criteria, for most patients with a body mass index (BMI=weight in kilograms divided by the height in meters squared) of 40 or more, or for patients with a BMI of 35 or more and significant health complications, surgery may be the only reliable option...
2013: Clinical and Translational Gastroenterology
Lukejohn W Day, John P Cello, Ma Somsouk, John M Inadomi
AIM: Prior studies have reported conflicting results on the yield of esophagogastroduodenoscopy (EGD) in patients with a positive fecal occult blood test (FOBT). Our aim was to compare the yield between EGD and colonoscopy performed in a racially diverse population with a positive FOBT. METHODS: A retrospective, cross-sectional study of FOBT positive patients who underwent EGD and colonoscopy from January 1, 1999 to November 1, 2008. Endoscopic lesions deemed responsible for GI bleeding were identified...
September 2011: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
Lisa M Brown, Stanley J Rogers, John P Cello, Karen J Brasel, John M Inadomi
BACKGROUND: Clinicians must choose a treatment strategy for patients with symptomatic cholelithiasis without knowing whether common bile duct (CBD) stones are present. The purpose of this study was to determine the most cost-effective treatment strategy for patients with symptomatic cholelithiasis and possible CBD stones. STUDY DESIGN: Our decision model included 5 treatment strategies: laparoscopic cholecystectomy (LC) alone followed by expectant management; preoperative endoscopic retrograde cholangiopancreatography (ERCP) followed by LC; LC with intraoperative cholangiography (IOC) ± common bile duct exploration (CBDE); LC followed by postoperative ERCP; and LC with IOC ± postoperative ERCP...
June 2011: Journal of the American College of Surgeons
Paul H Artes, Balwantray C Chauhan, John L Keltner, Kim E Cello, Chris A Johnson, Douglas R Anderson, Mae O Gordon, Michael A Kass
OBJECTIVE: To assess agreement between longitudinal and cross-sectional analyses for determining visual field progression in data from the Ocular Hypertension Treatment Study. METHODS: Visual field data from 3088 eyes of 1570 participants (median follow-up, 7 years) were analyzed. Longitudinal analyses were performed using change probability with total and pattern deviation, and cross-sectional analyses were performed using the glaucoma hemifield test, corrected pattern standard deviation, and mean deviation...
December 2010: Archives of Ophthalmology
John L Keltner, Chris A Johnson, Kimberly E Cello, Mariya Dontchev, Robin L Gal, Roy W Beck
OBJECTIVE: To evaluate visual field abnormalities after an episode of optic neuritis among participants in the Optic Neuritis Treatment Trial. METHODS: Three readers independently evaluated 10 443 visual fields from 454 patients and classified visual field abnormalities into 21 different monocular categories representing 3 general types of visual loss: diffuse, localized, and artifactual. Classification frequency was determined and reader agreement was evaluated...
March 2010: Archives of Ophthalmology
Lukejohn W Day, John P Cello, Erin Madden, Mark Segal
OBJECTIVES: To assess the completeness of gastrointestinal (GI) inpatient consultations at an academic teaching hospital. METHODS: We conducted a prospective, cross-sectional study of 278 inpatient GI consultation requests evaluated from 1 July 2005 to 31 May 2007. A questionnaire assessing multiple aspects of the requesting health-care providers' knowledge and documentation of patient information was completed by first-year GI fellows. Completeness of the consultation was evaluated by the GI consultation attending physician...
March 2010: American Journal of Gastroenterology
Stanley J Rogers, John P Cello, Jan K Horn, Allan E Siperstein, William P Schecter, Andre R Campbell, Robert C Mackersie, Alex Rodas, Huub T C Kreuwel, Hobart W Harris
OBJECTIVE: To compare outcome parameters for good-risk patients with classic signs, symptoms, and laboratory and abdominal imaging features of cholecystolithiasis and choledocholithiasis randomized to either laparoscopic cholecystectomy plus laparoscopic common bile duct exploration (LC+LCBDE) or endoscopic retrograde cholangiopancreatography sphincterotomy plus laparoscopic cholecystectomy (ERCP/S+LC). DESIGN: Our study was a prospective trial conducted following written informed consent, with randomization by the serially numbered, opaque envelope technique...
January 2010: Archives of Surgery
Stanley J Rogers, John P Cello, William P Schecter
BACKGROUND: : Pancreatic injury occurs in from 3% to 12% of patients with abdominal trauma. In many instances, a lack of impressive findings in the first 24 hours leads to a delay in diagnosis. Because pancreatic duct disruption is the major cause of traumatic pancreatitis, we evaluated our experience with endoscopic retrograde cholangiopancreatography (ERCP) in patients suspected of having of having pancreatic injury. METHODS: : We reviewed the medical records of 26 patients evaluated perioperatively by ERCP for suspected pancreatic duct injury...
March 2010: Journal of Trauma
Joelle Hillion, Lisa J Wood, Mita Mukherjee, Raka Bhattacharya, Francescopaolo Di Cello, Jeanne Kowalski, Ossama Elbahloul, Jodi Segal, John Poirier, Charles M Rudin, Surajit Dhara, Amy Belton, Biju Joseph, Stanley Zucker, Linda M S Resar
Although lung cancer is the leading cause of cancer death worldwide, the precise molecular mechanisms that give rise to lung cancer are incompletely understood. Here, we show that HMGA1 is an important oncogene that drives transformation in undifferentiated, large-cell carcinoma. First, we show that the HMGA1 gene is overexpressed in lung cancer cell lines and primary human lung tumors. Forced overexpression of HMGA1 induces a transformed phenotype with anchorage-independent cell growth in cultured lung cells derived from normal tissue...
November 2009: Molecular Cancer Research: MCR
John P Cello, Lukejohn W Day
Diarrhea in patients with acquired immune deficiency syndrome (AIDS) has proven to be both a diagnostic and treatment challenge since the discovery of the human immunodeficiency virus (HIV) virus more than 30 years ago. Among the main etiologies of diarrhea in this group of patients are infectious agents that span the array of viruses, bacteria, protozoa, parasites, and fungal organisms. In many instances, highly active antiretroviral therapy remains the cornerstone of therapy for both AIDS and AIDS-related diarrhea, but other targeted therapies have been developed as new pathogens are identified; however, some infections remain treatment challenges...
May 2009: Gastroenterology
Mark C Takata, Guilherme M Campos, Ruxandra Ciovica, Charlotte Rabl, Stanley J Rogers, John P Cello, Nancy L Ascher, Andrew M Posselt
BACKGROUND: To evaluate, at a university tertiary referral center, the safety and efficacy of laparoscopic Roux-en-Y gastric bypass (LRYGB) in patients with end-stage renal disease (ESRD) and laparoscopic sleeve gastrectomy (LSG) in patients with cirrhosis or end-stage lung disease (ESLD); and to determine whether these procedures help patients become better candidates for transplantation. METHODS: A retrospective review was performed of selected patients with end-stage organ failure who were not eligible for transplantation because of morbid obesity who underwent LRYGB or LSG...
March 2008: Surgery for Obesity and related Diseases: Official Journal of the American Society for Bariatric Surgery
Ma Somsouk, Amandeep K Shergill, James P Grenert, Hobart Harris, John P Cello, Janak N Shah
No abstract text is available yet for this article.
July 2008: Gastrointestinal Endoscopy
Eugene F Yen, Uri Ladabaum, V Raman Muthusamy, John P Cello, Kenneth R McQuaid, Janak N Shah
Although colonoscopy is used in the diagnostic evaluation of patients with diverticular hemorrhage, data on colonoscopic treatment outcomes are limited. We reviewed records of inpatients undergoing colonoscopy to identify patients that were colonoscopically diagnosed and treated for acute diverticular hemorrhage. Eleven patients with acute diverticular hemorrhage had active bleeding (n = 7) or non-bleeding visible vessel (n = 4) at colonoscopy. Endoclip treatment (preceded by epinephrine injection in 64%) achieved hemostasis in all patients without procedural complications...
September 2008: Digestive Diseases and Sciences
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