Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Uri Ladabaum, Ajitha Mannalithara, Yingjie Weng, Robert E Schoen, Jason A Dominitz, Manisha Desai, David Lieberman
BACKGROUND & AIMS: Colorectal cancer (CRC) screening is highly effective but underused. Blood-based biomarkers (eg, liquid biopsy) could improve screening participation. METHODS: Using our established Markov model, screening every 3 years with a blood-based test that meets minimum Centers for Medicare & Medicaid Services' thresholds (CMSmin ) (CRC sensitivity 74%, specificity 90%) was compared with established alternatives. Test attributes were varied in sensitivity analyses...
March 21, 2024: Gastroenterology
#2
EDITORIAL
Uri Ladabaum
No abstract text is available yet for this article.
March 26, 2024: Gastroenterology
#3
JOURNAL ARTICLE
Duco T Mülder, Anne I Hahn, Robert J Huang, Margaret J Zhou, Benjamin Blake, Omonefe Omofuma, John D Murphy, Daniela S Gutiérrez-Torres, Ann G Zauber, James F O'Mahony, M Constanza Camargo, Uri Ladabaum, Jennifer M Yeh, Chin Hur, Iris Lansdorp-Vogelaar, Reinier Meester, Monika Laszkowska
BACKGROUND AND AIMS: The prevalence of precursor lesions for gastric cancer (GC) and the differential burden between countries of varying GC risk is not well understood. We conducted a systematic review and meta-analysis to estimate the global prevalence of precursor lesions. METHODS: We estimated the prevalence of atrophic gastritis (AG), gastric intestinal metaplasia (IM), and dysplasia in regions with low, medium, and high-GC incidence. Since IM is an advanced manifestation of AG, we assessed the prevalence of less advanced precursors regardless of the presence of more advanced lesions...
March 2, 2024: Clinical Gastroenterology and Hepatology
#4
JOURNAL ARTICLE
Elizabeth E Half, Zohar Levi, Ajitha Mannalithara, Moshe Leshno, Irit Ben-Aharon, Naim Abu-Freha, Barbara Silverman, Uri Ladabaum
BACKGROUND: Colorectal cancer (CRC) incidence at ages <50 years is increasing worldwide. Screening initiation was lowered to 45 years in the United States. The cost-effectiveness of initiating CRC screening at 45 years in Israel was assessed with the aim of informing national policy and addressing internationally relevant questions. METHODS: A validated CRC screening model was calibrated to Israeli data and examined annual fecal immunochemical testing (FIT) or colonoscopy every 10 years from 45 to 74 years (FIT45-74 or Colo45-74) versus from 50 to 74 years (FIT50-74 or Colo50-74)...
January 5, 2024: Cancer
#5
JOURNAL ARTICLE
Mike Tzuhen Wei, Shmuel Fay, Diana Yung, Uri Ladabaum, Uri Kopylov
BACKGROUND: Artificial intelligence (AI) could minimize the operator-dependent variation in colonoscopy quality. Computer-aided detection (CADe) has improved adenoma detection rate (ADR) and adenomas per colonoscopy (APC) in randomized controlled trials (RCTs). There is a need to assess the impact of CADe in real-world settings. METHODS: We searched MEDLINE, EMBASE, and Web of Science for non-randomized, real-world studies of CADe in colonoscopy. Random-effects meta-analyses were performed to examine the effect of CADe on ADR and APC...
December 26, 2023: Clinical and Translational Gastroenterology
#6
JOURNAL ARTICLE
Uri Ladabaum
No abstract text is available yet for this article.
September 27, 2023: American Journal of Gastroenterology
#7
JOURNAL ARTICLE
Douglas K Rex, Uri Ladabaum, Joseph C Anderson, Aasma Shaukat, Lynn F Butterly, Jason A Dominitz, Tonya Kaltenbach, Theodore R Levin, Cesare Hassan
No abstract text is available yet for this article.
November 2023: Clinical Gastroenterology and Hepatology
#8
JOURNAL ARTICLE
Robert S Bresalier, Carlo Senore, Graeme P Young, James Allison, Robert Benamouzig, Sally Benton, Patrick M M Bossuyt, Luis Caro, Beatriz Carvalho, Han-Mo Chiu, Veerle M H Coupé, Willemijn de Klaver, Clasine Maria de Klerk, Evelien Dekker, Sunil Dolwani, Callum G Fraser, William Grady, Lydia Guittet, Samir Gupta, Stephen P Halloran, Ulrike Haug, Geir Hoff, Steven Itzkowitz, Tim Kortlever, Anastasios Koulaouzidis, Uri Ladabaum, Beatrice Lauby-Secretan, Mārcis Leja, Bernard Levin, Theodore Robert Levin, Finlay Macrae, Gerrit A Meijer, Joshua Melson, Colm O'Morain, Susan Parry, Linda Rabeneck, David F Ransohoff, Roque Sáenz, Hiroshi Saito, Silvia Sanduleanu-Dascalescu, Robert E Schoen, Kevin Selby, Harminder Singh, Robert J C Steele, Joseph J Y Sung, Erin Leigh Symonds, Sidney J Winawer
OBJECTIVE: New screening tests for colorectal cancer (CRC) are rapidly emerging. Conducting trials with mortality reduction as the end point supporting their adoption is challenging. We re-examined the principles underlying evaluation of new non-invasive tests in view of technological developments and identification of new biomarkers. DESIGN: A formal consensus approach involving a multidisciplinary expert panel revised eight previously established principles. RESULTS: Twelve newly stated principles emerged...
October 2023: Gut
#9
JOURNAL ARTICLE
Margaret J Zhou, Uri Ladabaum, George Triadafilopoulos, John O Clarke
The impact of race/ethnicity (RE) or socioeconomic status (SES) on progression from Barrett's esophagus (BE) to esophageal cancer (EC) is not well established. We aimed to evaluate the association between demographic factors and SES on EC diagnosis in an ethnically diverse BE cohort. Patients aged 18-63 with incident BE diagnosed in October 2015-March 2020 were identified in the Optum Clinformatics DataMart Database. Patients were followed until the diagnosis of prevalent EC <1 year or incident EC ≥1 year from BE diagnosis, or until the end of their continuous enrollment period...
July 10, 2023: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
#10
EDITORIAL
Uri Ladabaum, Cynthia W Ko
No abstract text is available yet for this article.
April 24, 2023: Clinical Gastroenterology and Hepatology
#11
JOURNAL ARTICLE
Elyssa Zukin, Julie O Culver, Yuxi Liu, Yunqi Yang, Charité N Ricker, Rachel Hodan, Duveen Sturgeon, Kerry Kingham, Nicolette M Chun, Courtney Rowe-Teeter, Kathryn Singh, Jason A Zell, Uri Ladabaum, Kevin J McDonnell, James M Ford, Giovanni Parmigiani, Danielle Braun, Allison W Kurian, Stephen B Gruber, Gregory E Idos
PURPOSE: To describe the clinical impact of commercial laboratories issuing conflicting classifications of genetic variants. METHODS: Results from 2,000 patients undergoing a multi-gene hereditary cancer panel by a single laboratory were analyzed. Clinically significant discrepancies between the lab provided test reports and other major commercial laboratories were identified, including differences between pathogenic/likely pathogenic (P/LP) and variant of uncertain significance (VUS) classifications, via review of ClinVar archives...
April 10, 2023: Genetics in Medicine: Official Journal of the American College of Medical Genetics
#12
REVIEW
Sandra Baile-Maxía, Carolina Mangas-Sanjuán, Uri Ladabaum, Cesare Hassan, Matthew D Rutter, Michael Bretthauer, Lucía Medina-Prado, Noelia Sala-Miquel, Oscar Murcia Pomares, Pedro Zapater, Rodrigo Jover
BACKGROUND & AIMS: Among the characteristics of high-risk adenomas (HRAs), some may predict a higher risk of metachronous advanced lesions. Our aim was to assess which HRA characteristics are associated with high risk of metachronous colorectal cancer (CRC) or advanced adenomas (AAs). METHODS: We systematically searched Pubmed, EMBASE, and Cochrane for cohort studies and clinical trials of CRC or AA incidence at surveillance stratified by baseline lesion size, histology, and multiplicity...
March 2023: Clinical Gastroenterology and Hepatology
#13
LETTER
Uri Ladabaum, John Shepard, Yingjie Weng, Manisha Desai, Sara J Singer, Ajitha Mannalithara
No abstract text is available yet for this article.
March 2023: Gastroenterology
#14
JOURNAL ARTICLE
Margaret J Zhou, Gurkirpal Singh, Joo Ha Hwang, Uri Ladabaum
No abstract text is available yet for this article.
December 1, 2022: Clinical Gastroenterology and Hepatology
#15
JOURNAL ARTICLE
Soham Sinha, Zixuan Li, Ari Bar-Mashiah, Uri Ladabaum, Ravi N Sharaf
No abstract text is available yet for this article.
August 22, 2022: Gastroenterology
#16
JOURNAL ARTICLE
Aaron Yeoh, Ajitha Mannalithara, Uri Ladabaum
BACKGROUND & AIMS: Overweight and obese persons have not only elevated rates of colorectal cancer (CRC), but also higher competing mortality and healthcare spending. We examined the cost-effectiveness of intensified CRC screening in overweight and obese persons. METHODS: We adapted our validated decision analytic model of CRC screening to compare screening starting at 45 or 40 years of age instead of at 50 years of age, or shortening screening intervals, in women and men with body mass index (BMI) ranging from normal to grade III obesity...
August 5, 2022: Clinical Gastroenterology and Hepatology
#17
JOURNAL ARTICLE
Winston R Becker, Stephanie A Nevins, Derek C Chen, Roxanne Chiu, Aaron M Horning, Tuhin K Guha, Rozelle Laquindanum, Meredith Mills, Hassan Chaib, Uri Ladabaum, Teri Longacre, Jeanne Shen, Edward D Esplin, Anshul Kundaje, James M Ford, Christina Curtis, Michael P Snyder, William J Greenleaf
To chart cell composition and cell state changes that occur during the transformation of healthy colon to precancerous adenomas to colorectal cancer (CRC), we generated single-cell chromatin accessibility profiles and single-cell transcriptomes from 1,000 to 10,000 cells per sample for 48 polyps, 27 normal tissues and 6 CRCs collected from patients with or without germline APC mutations. A large fraction of polyp and CRC cells exhibit a stem-like phenotype, and we define a continuum of epigenetic and transcriptional changes occurring in these stem-like cells as they progress from homeostasis to CRC...
July 2022: Nature Genetics
#18
JOURNAL ARTICLE
David Lieberman, Uri Ladabaum, Joel V Brill, Folasade P May, Lawrence S Kim, Caitlin Murphy, Richard Wender, Kathleen Teixeira
No abstract text is available yet for this article.
June 4, 2022: Gastroenterology
#19
JOURNAL ARTICLE
Srinadh Komanduri, Jason A Dominitz, Linda Rabeneck, Charles Kahi, Uri Ladabaum, Thomas F Imperiale, Michael F Byrne, Jeffrey K Lee, David Lieberman, Andrew Y Wang, Shahnaz Sultan, Aasma Shaukat, Heiko Pohl, V Raman Muthusamy
In 2018, the American Gastroenterological Association's Center for GI Innovation and Technology convened a consensus conference, entitled "Colorectal Cancer Screening and Surveillance: Role of Emerging Technology and Innovation to Improve Outcomes." The conference participants, which included more than 60 experts in colorectal cancer, considered recent improvements in colorectal cancer screening rates and polyp detection, persistent barriers to colonoscopy uptake, and opportunities for performance improvement and innovation...
October 2022: Clinical Gastroenterology and Hepatology
#20
JOURNAL ARTICLE
Uri Ladabaum, John Shepard, Ajitha Mannalithara
BACKGROUND AND AIMS: All major U.S. guidelines now endorse average-risk colorectal cancer (CRC) screening at 45-49 years of age. Concerns exist that endoscopic capacity may be strained, that low-risk persons may self-select for screening, and that calculations of the adenoma detection rate may be diluted. We analyzed age-specific screening colonoscopy volumes and lesion detection rates before vs after the endorsement of CRC screening at 45-49 years of age. METHODS: We compared colonoscopy volumes and lesion detection rates in our healthcare system during period 1 (October 2017 to December 2018), before the first change in guidelines, vs period 2 (January 2019 to August 2021), the era of new guidelines...
December 2022: Clinical Gastroenterology and Hepatology
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
