Helena Turano, Fernando Gomes, Gesiele A Barros-Carvalho, Ralf Lopes, Louise Cerdeira, Luis E S Netto, Ana C Gales, Nilton Lincopan
A novel transposon belonging to the Tn3-like family was identified on the chromosome of a commensal strain of Pseudomonas aeruginosa ST2343. Tn6350 is 7,367 bp in size, harboring eight ORFs, an ATPase (IS481 family), a transposase (DDE catalytic type), a Tn3 resolvase, three hypothetical proteins, and genes encoding the new pyocin S8 with their immunity protein. We show that pyocin S8 displays activity against carbapenemase-producing P. aeruginosa, including IMP-1, SPM-1, VIM-1, GES-5 and KPC-2 producers.
February 27, 2017: Antimicrobial Agents and Chemotherapy