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Livedo reticularis

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https://www.readbyqxmd.com/read/27858977/atypical-presentation-of-livedo-racemosa-in-a-factor-v-leiden-heterozygous-positive-patient-with-pseudomonas-aeruginosa-urosepsis
#1
Jesse Johnston, Rowland Noakes, Kurt Davidson
Impairment of the protein C pathway, detectable by reduced plasma levels of activated protein C (APC), are risk factors for venous thrombosis. Activated protein C maintains clotting homeostasis by regulation of pro-coagulant factors Va and VIIIa. Both infection and the factor V Leiden mutation reduce the formation of APC from protein C in the blood. With low levels of APC, excess factors Va and VIIIa exist, increasing the risk of thrombus formation. Livedo racemosa is characterised by a striking, violaceous branch-like pattering of the skin...
November 12, 2016: Australasian Journal of Dermatology
https://www.readbyqxmd.com/read/27793390/spontaneous-multivisceral-cholesterol-crystal-embolism-presenting-as-livedo-reticularis
#2
P Carmona Sánchez, M T González Serrano, J M Serrano Simón
No abstract text is available yet for this article.
October 25, 2016: Medicina Intensiva
https://www.readbyqxmd.com/read/27776934/the-antiphospholipid-syndrome-in-patients-with-systemic-lupus-erythematosus
#3
Guillermo J Pons-Estel, Laura Andreoli, Francesco Scanzi, Ricard Cervera, Angela Tincani
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the occurrence of venous and/or arterial thrombosis and pregnancy morbidity in the presence of pathogenic autoantibodies known as antiphospholipid antibodies (aPL). APS may be associated with other diseases, mainly systemic lupus erythematosus (SLE). The presence or absence of SLE might modify the clinical or serological expression of APS. Apart from the classical manifestations, APS patients with associated SLE more frequently display a clinical profile with arthralgias, arthritis, autoimmune hemolytic anemia, livedo reticularis, epilepsy, glomerular thrombosis, and myocardial infarction...
October 21, 2016: Journal of Autoimmunity
https://www.readbyqxmd.com/read/27708976/the-clinical-significance-of-antiphospholipid-antibodies-in-systemic-lupus-erythematosus
#4
Ozan Ünlü, Stephane Zuily, Doruk Erkan
Antiphospholipid syndrome (APS) is the association of thrombosis and/or pregnancy morbidity with antiphospholipid antibodies (aPL). Thirty to forty percent of systemic lupus erythematosus (SLE) patients are tested positive for aPL, which may have an impact on the SLE presentation, management, and prognosis. Compared with SLE patients without aPL, those with aPL have a higher prevalence of thrombosis, pregnancy morbidity, valve disease, pulmonary hypertension, livedo reticularis, thrombocytopenia, hemolytic anemia, acute/chronic renal vascular lesions, and moderate/severe cognitive impairment; worse quality of life; and higher risk of organ damage...
June 2016: Eur J Rheumatol
https://www.readbyqxmd.com/read/27609179/monogenic-polyarteritis-the-lesson-of-ada2-deficiency
#5
REVIEW
Roberta Caorsi, Federica Penco, Francesca Schena, Marco Gattorno
The deficiency of Adenosine Deaminase 2 (DADA2) is a new autoinflammatory disease characterised by an early onset vasculopathy with livedoid skin rash associated with systemic manifestations, CNS involvement and mild immunodeficiency.This condition is secondary to autosomal recessive mutations of CECR1 (Cat Eye Syndrome Chromosome Region 1) gene, mapped to chromosome 22q11.1, that encodes for the enzymatic protein adenosine deaminase 2 (ADA2). By now 19 different mutations in CECR1 gene have been detected...
September 8, 2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27496315/painful-subcutaneous-nodules-in-a-patch-of-livedo-reticularis
#6
Peter Barnes, Cindi Chapman, Nicole Fett
No abstract text is available yet for this article.
August 6, 2016: International Journal of Dermatology
https://www.readbyqxmd.com/read/27490977/branch-retinal-artery-occlusion-associated-with-paracentral-acute-middle-maculopathy-in-a-patient-with-livedo-reticularis
#7
Paul Baciu, Candice M Nofar, Justin Spaulding, Hua Gao
PURPOSE: To report the occurrence of a branch retinal artery occlusion with paracentral acute middle maculopathy in an otherwise healthy young man with a history of livedo reticularis (LR). METHODS: Retrospective case report. PATIENTS: A 21-year-old man with a history of LR being treated with pentoxifylline developed an acute branch retinal artery occlusion with initial best-corrected visual acuity at presentation of 20/80. RESULTS: A thorough diagnostic work up was negative for potential causes of branch retinal artery occlusion or LR...
August 2, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27384637/-dermatomiositis-and-evans-syndrome-associated-with-htlv-1-infection
#8
David Loja-Oropeza, Ernesto Zavala-Flores, Maricela Vilca-Vasquez
A 55-year-old female patient, born in Ayacucho, with a history of dermatomyositis for 3 years, who received irregular treatment with prednisone. Two months prior to admission, she presented with autoinmune hemolytic anemia and idiopathic thrombocytopenic purpura. The patient received methylprednisolone pulse therapy and packed red blood cells transfusions. Upon admission, she was drowsy, with a poor overall status, marked weight loss, dehydration, with presence of livedo reticularis in her lower extremities, and onychodystrophy and onycholysis on the toes of both feet...
March 2016: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/27267327/the-correlation-between-antiphospholipid-syndrome-and-cryoglobulinemia-case-series-of-4-patients-and-review-of-the-literature
#9
Shiber Shachaf, Molad Yair
BACKGROUND: Cryoglobulinemia is an immune-complex-mediated small vessel vasculitis that classically involves the skin, kidneys and peripheral nerves. Antiphospholipid syndrome (APS) is an autoimmune hypercoagulable disorder which causes blood vessel thrombosis. It can present as a multi-organ microthrombotic disorder which is called catastrophic APS. OBJECTIVE: In this case series we aim to describe the diagnostic and management challenges that arise when these two severe disorders simultaneously present in the same patient...
January 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27260006/type-i-interferonopathies-in-pediatric-rheumatology
#10
REVIEW
Stefano Volpi, Paolo Picco, Roberta Caorsi, Fabio Candotti, Marco Gattorno
Defective regulation of type I interferon response is associated with severe inflammatory phenotypes and autoimmunity. Type I interferonopathies are a clinically heterogenic group of Mendelian diseases with a constitutive activation of this pathway that might present as atypical, severe, early onset rheumatic diseases. Skin vasculopathy with chilblains and livedo reticularis, interstitial lung disease, and panniculitis are common. Recent studies have implicated abnormal responses to nucleic acid stimuli or defective regulation of downstream effector molecules in disease pathogenesis...
2016: Pediatric Rheumatology Online Journal
https://www.readbyqxmd.com/read/27252126/adverse-reaction-after-hyaluronan-injection-for-minimally-invasive-papilla-volume-augmentation-a-report-on-two-cases
#11
Kristina Bertl, Klaus Gotfredsen, Simon S Jensen, Corinna Bruckmann, Andreas Stavropoulos
OBJECTIVES: To report two cases of adverse reaction after mucosal hyaluronan (HY) injection around implant-supported crowns, with the aim to augment the missing interdental papilla. MATERIAL AND METHODS: Two patients with single, non-neighbouring, implants in the anterior maxilla, who were treated within the frames of a randomized controlled clinical trial testing the effectiveness of HY gel injection to reconstruct missing papilla volume at single implants, presented an adverse reaction...
June 1, 2016: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/27234436/susac-syndrome-with-prominent-dermatological-findings-and-a-prompt-response-to-intravenous-immunoglobulin-steroids-and-rituximab-a-case-report
#12
Elie Gertner, Michael H Rosenbloom
BACKGROUND: Susac syndrome (retinocochleocerebral vasculopathy) is an autoimmune endotheliopathy affecting the precapillary arterioles of the brain, retina, and inner ear. It presents with encephalopathy, branch retinal artery occlusions, and hearing loss. The condition is often under recognized because the clinical symptoms may present at different times and physicians may be unfamiliar with the syndrome. Peripheral findings would be helpful in early diagnosis. There are numerous treatment regimens proposed with varying effectiveness...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27085226/coagulation-disorders-and-their-cutaneous-presentations-diagnostic-work-up-and-treatment
#13
REVIEW
Ganary Dabiri, Elizabeth Damstetter, Yunyoung Chang, Emily Baiyee Ebot, Jennifer Gloeckner Powers, Tania Phillips
Both inherited and acquired hypercoagulable states can present with nonspecific clinical manifestations, such as petechiae, purpura, livedo reticularis, and ulcerations. A good history and physical examination are crucial to diagnoses of these conditions. Inherited conditions tend to present either in neonatal period or later in life, while acquired conditions typically occur later in life. Diagnostic studies are performed to identify the coagulation cascade deficiency or defect. Treatment primarily hinges on anticoagulation and wound care...
May 2016: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/26972993/a-systematic-review-and-meta-analysis-of-cutaneous-manifestations-in-late-versus-early-onset-systemic-lupus-erythematosus
#14
Jennifer L Medlin, Karen E Hansen, Sara R Fitz, Christie M Bartels
OBJECTIVES: Although systemic lupus erythematosus (SLE) most commonly occurs in reproductive-age women, some are diagnosed after the age of 50. Recognizing that greater than one-third of SLE criteria are cutaneous, we undertook a systematic review and meta-analysis to evaluate differences in cutaneous manifestations in early- and late-onset SLE patients. METHODS: We searched the literature using PubMed, CINAHL, Web of Science, and Cochrane Library. We excluded studies that did not include ACR SLE classification criteria, early-onset controls, that defined late-onset SLE as <50 years of age, or were not written in English...
June 2016: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/26968196/sneddon-s-syndrome-it-is-all-in-the-ectoderm
#15
Zoe Rutter-Locher, Zhongbo Chen, Lorena Flores, Tanya Basu, Daniel Creamer, Robert Weeks, Roopen Arya, Lina Nashef
A 51-year-old man gave a 2-year history of worsening mobility, cognitive decline and headaches. He had a history of thromboembolic stroke, recurrent transient ischaemic attacks and a spontaneous intraventricular haemorrhage. On examination, he had livedo reticularis and perniosis and a systolic murmur. Catheter cerebral angiography showed peripheral small-vessel and medium-vessel vasculopathy resulting in pruning of the distal cortical vessels and tortuous irregular distal collaterals. Skin biopsy showed subtle vasculopathy with ectasia of capillaries and postcapillary venules but no frank vasculitis or arterial thrombosis...
August 2016: Practical Neurology
https://www.readbyqxmd.com/read/26944370/erythema-induratum-of-bazin-and-pon%C3%A3-et-s-arthropathy-as-epiphenomena-of-hepatic-tuberculosis
#16
Rita Ribeiro, Catarina Patrício, Filipa Pais da Silva, Pedro Eduardo Silva
A 42-year-old black woman presented with fever, polyarthritis, livedo reticularis, subcutaneous calf nodules and hepatomegaly. She had been diagnosed with depression 6 weeks prior. Blood analysis showed anaemia, elevated erythrocyte sedimentation rate and C reactive protein, elevated liver enzymes, and positive antinuclear and antiribonucleoprotein antibodies. Abdominal ultrasound revealed heterogeneous hepatomegaly with necrotic lymphadenopathy around the caeliac trunk and splenic hilum. We considered the following diagnoses: lymphoma, connective tissue disease, tuberculosis and sarcoidosis...
2016: BMJ Case Reports
https://www.readbyqxmd.com/read/26877518/p-212-sneddon-syndrome-causing-stroke-on-young-about-an-observation
#17
N Benmostefa, I Baretil, A Bouchoucha, S Kouach, A Rouina, R Malek
OBJECTIFS: Le syndrome de Sneddon (SS) représente une cause rare d'accidents vasculaires cérébraux (AVC). La prise en charge passe d'abord par la prévention des facteurs de risque et repose surtout sur les traitements antithrombotiques. MéTHODES: Un cas rapporté. RéSULTATS: Patiente de 50 ans, mère de 5EVBP, aux antécédents d'une HTA et de 3 accouchements prématurés, a été admise en service de médecine interne pour pris en charge d'un phénomène de Raynaud sévère compliqué d'une ischémie du gros orteil...
December 2015: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/26610893/dermatological-manifestations-of-postural-tachycardia-syndrome-are-common-and-diverse
#18
Hao Huang, Anindita Deb, Collin Culbertson, Karen Morgenshtern, Anna DePold Hohler
BACKGROUND AND PURPOSE: Postural tachycardia syndrome (POTS) is a syndrome of orthostatic intolerance in the setting of excessive tachycardia with orthostatic challenge, and these symptoms are relieved when recumbent. Apart from symptoms of orthostatic intolerance, there are many other comorbid conditions such as chronic headache, fibromyalgia, gastrointestinal disorders, and sleep disturbances. Dermatological manifestations of POTS are also common and range widely from livedo reticularis to Raynaud's phenomenon...
January 2016: Journal of Clinical Neurology
https://www.readbyqxmd.com/read/26560223/amantadine-induced-livedo-reticularis-case-report
#19
Maria Victória Quaresma, Ana Carolina Dias Gomes, Aline Serruya, Dâmia Leal Vendramini, Lara Braga, Alice Mota Buçard
Livedo reticularis is a spastic-anatomical condition of the small vessels which translates morphologically by a reticular pattern, interspersing cyanosis, pallor and erythema. The same can be congenital or acquired. Among the acquired, we highlight the physiological livedo reticularis and the idiopathic livedo by vasospasm; the latter configures the most common cause. The drug-induced type is less common. The drugs amantadine and norepinephrine are often implicated. Cyanosis is usually reversible if the causative factor is removed, however, with chronicity, the vessels may become permanently dilated and telangiectatic...
September 2015: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/26511022/-mononeuritis-multiplex-due-to-thrombotic-ischemia-of-primary-antiphospholipid-antibody-syndrome-without-vasculitis-an-autopsy-case-report
#20
Masatoshi Takahashi, Fumiaki Katada, Susumu Sato, Hidehiro Shibayama, Toshio Fukutake, Shigeo Murayama
The patient was a 78-year-old man. Three years before admission, he developed transient peripheral neuropathy and purpura, and at admission, he presented with livedo reticularis of both his lower extremities and with mononeuritis multiplex. Vasculitis was not observed, and antiphospholipid antibodies were detected. The nerve and skin biopsies revealed no inflammation; axonal degeneration accompanied by thrombi was found in his arterioles and venules. Based on these findings, he was diagnosed with ischemic peripheral neuropathy due to primary antiphospholipid syndrome...
2015: Rinshō Shinkeigaku, Clinical Neurology
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