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https://www.readbyqxmd.com/read/29662867/an-unusual-etiology-of-plummer-vinson-syndrome
#1
Ankur Jain, Parimal Agrawal, Pankaj Malhotra, Ritambhra Nada, Subhash Varma
No abstract text is available yet for this article.
March 2018: Blood Research
https://www.readbyqxmd.com/read/29622624/relationship-between-dual-task-gait-speed-and-walking-activity-poststroke
#2
Jody A Feld, Lisa A Zukowski, Annie G Howard, Carol A Giuliani, Lori J P Altmann, Bijan Najafi, Prudence Plummer
BACKGROUND AND PURPOSE: Gait speed does not adequately predict whether stroke survivors will be active in the community. This may be because traditional single-task gait speed does not sufficiently reproduce the demands of walking in the real world. This study assessed whether dual-task gait speed accounts for variance in daily ambulatory activity above what can be predicted with habitual (single task) gait speed in community-dwelling stroke survivors. METHODS: Twenty-eight community-dwelling individuals, 58...
April 5, 2018: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/29618899/hypothetical-endogenous-siv-like-antigens-in-mauritian-cynomolgus-macaques
#3
Hongzhao Li, Lin Li, Lewis R Liu, Robert W Omange, Nikki Toledo, Mohammad Abul Kashem, Yan Hai, Binhua Liang, Francis A Plummer, Ma Luo
Simian immunodeficiency virus (SIV) infection of Mauritian cynomolgus macaques (MCMs) is an increasingly important nonhuman primate model for HIV vaccine research. We previously reported that in MCMs anti-SIV antibodies can be naturally developed without exogenous infection or vaccination, and that a vaccine targeting SIV protease cleavage sites (PCS) can cross-induce antibodies to non-PCS SIV antigens. We speculate that this is potentially caused by the existence of endogenous SIV-like antigens. External stimuli (such as environmental factors and vaccination) may induce expression of endogenous SIV-like antigens to elicit these antibodies...
2018: Bioinformation
https://www.readbyqxmd.com/read/29605199/the-acute-effects-of-bronchial-thermoplasty-on-fev-1
#4
David Langton, Wei Wang, Francis Thien, Virginia Plummer
BACKGROUND: The most common adverse effect of bronchial thermoplasty (BT) is short-term aggravation of asthma immediately following the procedure. However, the magnitude and duration of this deterioration, and its predisposing factors are yet to be quantitated. This information will be particularly important as BT is extended to include more severely obstructed patients. METHODS: In this prospective, observational study of 20 consecutive patients with very severe asthma undergoing BT, post bronchodilator FEV1 was measured in the 30 min prior to surgery, and then 24 h following the 60 procedures...
April 2018: Respiratory Medicine
https://www.readbyqxmd.com/read/29600767/identification-and-characterization-of-positively-selected-mutations-in-nef-of-four-hiv-1-major-subtypes-from-los-alamos-national-laboratory
#5
Elnaz Shadabi, Binhua Liang, Francis A Plummer, Ma Luo
BACKGROUND: Human immunodeficiency virus-1 (HIV-1) mutates rapidly to escape host immune pressure. This results in the generation of positively selected mutations (PSM) throughout the viral genome. Escape mutations in Nef, one of the accessory proteins of HIV-1, which plays an important role in viral pathogenicity have previously been identified in several large cohort studies, but the evolution of PSMs overtime in various HIV-1 subtypes remains unknown. METHODS: 161 clade A1, 3093 clade B, 647 clade C and 115 clade D HIV-1 nef sequences were obtained from the HIV Database of Los Alamos National Laboratory and aligned using MEGA 6...
March 30, 2018: Current HIV Research
https://www.readbyqxmd.com/read/29562672/the-incidence-and-genetic-diversity-of-apple-mosaic-virus-apmv-and-prune-dwarf-virus-pdv-in-prunus-species-in-australia
#6
Wycliff M Kinoti, Fiona E Constable, Narelle Nancarrow, Kim M Plummer, Brendan Rodoni
Apple mosaic virus (ApMV) and prune dwarf virus (PDV) are amongst the most common viruses infecting Prunus species worldwide but their incidence and genetic diversity in Australia is not known. In a survey of 127 Prunus tree samples collected from five states in Australia, ApMV and PDV occurred in 4 (3%) and 13 (10%) of the trees respectively. High-throughput sequencing (HTS) of amplicons from partial conserved regions of RNA1, RNA2, and RNA3, encoding the methyltransferase (MT), RNA-dependent RNA polymerase (RdRp), and the coat protein (CP) genes respectively, of ApMV and PDV was used to determine the genetic diversity of the Australian isolates of each virus...
March 19, 2018: Viruses
https://www.readbyqxmd.com/read/29559521/fxr-activation-by-obeticholic-acid-or-non-steroidal-agonists-induces-a-human-like-lipoprotein-cholesterol-change-in-mice-with-humanized-chimeric-liver
#7
Romeo Papazyan, Xueqing Liu, Jingwen Liu, Bin Dong, Emily M Plummer, Ronald D Lewis, Jonathan D Roth, Mark A Young
Obeticholic acid (OCA) is a selective farnesoid X receptor (FXR) agonist that regulates bile acid and lipid metabolism. FXR activation induces distinct changes in circulating cholesterol among animal models and humans. The mechanistic basis of these effects has been elusive because of difficulties in studying lipoprotein homeostasis in mice, which predominantly package circulating cholesterol in high-density lipoproteins. Here, we tested the effects of OCA in chimeric mice whose livers are mostly composed (≥80%) of human hepatocytes...
March 20, 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29556478/dose-dependent-effects-on-rat-liver-mirnas-200a-b-and-429-potential-early-biomarkers-of-liver-carcinogenesis
#8
S M Plummer, J Wright, R A Currie
An increased incidence of liver tumours in the long term rodent bioassay is not an uncommon finding, invariably as a result of a non-genotoxic mode of action. Non-genotoxic liver carcinogenesis has been found to involve activation of certain nuclear hormone receptors (NHR) including the constitutive androstane receptor (CAR), peroxisome proliferator activated receptor alpha (PPARalpha) and arylhydrocarbon receptor (AHR) and more recently the induction of specific microRNAs (miRs), has also been demonstrated following CAR activation in studies up to 90 days (Koufaris et al...
2018: Toxicology Reports
https://www.readbyqxmd.com/read/29547122/spin1-promotes-tumorigenesis-by-blocking-the-ul18-universal-large-ribosomal-subunit-protein-18-mdm2-p53-pathway-in-human-cancer
#9
Ziling Fang, Bo Cao, Jun-Ming Liao, Jun Deng, Kevin D Plummer, Peng Liao, Tao Liu, Wensheng Zhang, Kun Zhang, Li Li, David Margolin, Shelya X Zeng, Jianping Xiong, Hua Lu
Ribosomal proteins (RPs) play important roles in modulating the MDM2-p53 pathway. However, less is known about the upstream regulators of the RPs. Here we identify SPIN1 (Spindlin 1) as a novel binding partner of human RPL5/uL18 that is important for this pathway. SPIN1 ablation activates p53, suppresses cell growth, reduces clonogenic ability, and induces apoptosis of human cancer cells. Mechanistically, SPIN1 sequesters uL18 in the nucleolus, preventing it from interacting with MDM2, and thereby alleviating uL18-mediated inhibition of MDM2 ubiquitin ligase activity towards p53...
March 16, 2018: ELife
https://www.readbyqxmd.com/read/29527424/formaldehyde-in-the-tropical-western-pacific-chemical-sources-and-sinks-convective-transport-and-representation-in-cam-chem-and-the-ccmi-models
#10
Daniel C Anderson, Julie M Nicely, Glenn M Wolfe, Thomas F Hanisco, Ross J Salawitch, Timothy P Canty, Russell R Dickerson, Eric C Apel, Sunil Baidar, Thomas J Bannan, Nicola J Blake, Dexian Chen, Barbara Dix, Rafael P Fernandez, Samuel R Hall, Rebecca S Hornbrook, L Gregory Huey, Beatrice Josse, Patrick Jöckel, Douglas E Kinnison, Theodore K Koenig, Michael LeBreton, Virginie Marécal, Olaf Morgenstern, Luke D Oman, Laura L Pan, Carl Percival, David Plummer, Laura E Revell, Eugene Rozanov, Alfonso Saiz-Lopez, Andrea Stenke, Kengo Sudo, Simone Tilmes, Kirk Ullmann, Rainer Volkamer, Andrew J Weinheimer, Guang Zeng
Formaldehyde (HCHO) directly affects the atmospheric oxidative capacity through its effects on HOx . In remote marine environments, such as the Tropical Western Pacific (TWP), it is particularly important to understand the processes controlling the abundance of HCHO because model output from these regions is used to correct satellite retrievals of HCHO. Here, we have used observations from the CONTRAST field campaign, conducted during January and February 2014, to evaluate our understanding of the processes controlling the distribution of HCHO in the TWP as well as its representation in chemical transport/climate models...
October 27, 2017: Journal of Geophysical Research. Atmospheres: JGR
https://www.readbyqxmd.com/read/29491026/local-extinction-of-the-asian-tiger-mosquito-aedes-albopictus-following-rat-eradication-on-palmyra-atoll
#11
Kevin D Lafferty, John P McLaughlin, Daniel S Gruner, Taylor A Bogar, An Bui, Jasmine N Childress, Magaly Espinoza, Elizabeth S Forbes, Cora A Johnston, Maggie Klope, Ana Miller-Ter Kuile, Michelle Lee, Katherine A Plummer, David A Weber, Ronald T Young, Hillary S Young
The Asian tiger mosquito, Aedes albopictus, appears to have been extirpated from Palmyra Atoll following rat eradication. Anecdotal biting reports, collection records, and regular captures in black-light traps showed the species was present before rat eradication. Since then, there have been no biting reports and no captures over 2 years of extensive trapping (black-light and scent traps). By contrast, the southern house mosquito, Culex quinquefasciatus, was abundant before and after rat eradication. We hypothesize that mammals were a substantial and preferred blood meal for Aedes , whereas Culex feeds mostly on seabirds...
February 2018: Biology Letters
https://www.readbyqxmd.com/read/29484242/trunk-lean-during-a-single-leg-squat-is-associated-with-trunk-lean-during-pitching
#12
Hillary A Plummer, Gretchen D Oliver, Christopher M Powers, Lori A Michener
Background: Impaired trunk motion during pitching may be a risk factor for upper extremity injuries. Specifically, increased forces about the shoulder and elbow have been observed in pitchers with excessive contralateral trunk lean during pitching. Because of the difficulty in identifying abnormal trunk motions during a high-speed task such as pitching, a clinical screening test is needed to identify pitchers who have impaired trunk motion during pitching. Hypothesis/Purpose: The purpose of this study was to determine the relationship between the degree of lateral trunk lean during the single-leg squat and amount of trunk lean during pitching and if trunk lean during pitching can be predicted from lean during the single-leg squat...
February 2018: International Journal of Sports Physical Therapy
https://www.readbyqxmd.com/read/29482261/amniotic-membrane-transplantation-for-ligneous-conjunctivitis-in-a-doberman
#13
Louise O'Leary, Andrew Specht, Natalie Isaza, Maria Kallberg, Kathleen Barrie, Deborah Cottrell, Caryn Plummer
An approximately 2-year-old female Doberman Pinscher was referred for the evaluation of bilateral, chronic proliferative conjunctivitis. Ophthalmic examination revealed bilateral thick, opaque pseudomembranes originating from the conjunctivae that prevented visualization of the cornea and interior structures of the eye. Histopathological findings of biopsies of the pseudomembranes were consistent with ligneous conjunctivitis. Serum plasminogen activity levels were within the normal range. Treatment with topical and systemic anti-inflammatory and immunosuppressive drugs did not improve the conjunctival lesions...
February 26, 2018: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/29466040/determination-of-anatomic-landmarks-for-optimal-placement-in-captive-bolt-euthanasia-of-goats
#14
Paul J Plummer, Jan K Shearer, Katie E Kleinhenz, Leslie C Shearer
OBJECTIVE To determine the optimal anatomic site and directional aim of a penetrating captive bolt (PCB) for euthanasia of goats. SAMPLE 8 skulls from horned and polled goat cadavers and 10 anesthetized horned and polled goats scheduled to be euthanized at the end of a teaching laboratory. PROCEDURES Sagittal sections of cadaver skulls from 8 horned and polled goats were used to determine the ideal anatomic site and aiming of a PCB to maximize damage to the midbrain region of the brainstem for euthanasia. Anatomic sites for ideal placement and directional aiming were confirmed by use of 10 anesthetized horned and polled goats...
March 2018: American Journal of Veterinary Research
https://www.readbyqxmd.com/read/29457358/crt-survey-ii-a-european-society-of-cardiology-survey-of-cardiac-resynchronisation-therapy-in-11-088-patients-who-is-doing-what-to-whom-and-how
#15
Kenneth Dickstein, Camilla Normand, Angelo Auricchio, Nigussie Bogale, John G Cleland, Anselm K Gitt, Christoph Stellbrink, Stefan D Anker, Gerasimos Filippatos, Maurizio Gasparini, Gerhard Hindricks, Carina Blomström Lundqvist, Piotr Ponikowski, Frank Ruschitzka, Giovanni Luca Botto, Alan Bulava, Gabor Duray, Carsten Israel, Christophe Leclercq, Peter Margitfalvi, Óscar Cano, Chris Plummer, Nedim Umutay Sarigul, Maciej Sterlinski, Cecilia Linde
BACKGROUND: Cardiac resynchronisation therapy (CRT) reduces morbidity and mortality in appropriately selected patients with heart failure and is strongly recommended for such patients by guidelines. A European Society of Cardiology (ESC) CRT survey conducted in 2008-2009 showed considerable variation in guideline adherence and large individual, national and regional differences in patient selection, implantation practice and follow-up. Accordingly, two ESC associations, the European Heart Rhythm Association and the Heart Failure Association, designed a second prospective survey to describe contemporary clinical practice regarding CRT...
February 19, 2018: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29452377/discordance-in-the-dependence-on-kisspeptin-signaling-in-mini-puberty-vs-adolescent-puberty-human-genetic-evidence
#16
Muhammad Shahab, Margaret Lippincott, Yee-Ming Chan, Addie Davies, Paulina M Merino, Lacey Plummer, Veronica Mericq, Stephanie Seminara
Context: Hypothalamic kisspeptin signaling plays a critical role in the initiation and maintenance of reproductive function. Biallelic mutations in the coding sequence of KISS1R (GPR54) have been identified in patients with idiopathic hypogonadotropic hypogonadism (IHH), but it is unknown whether biallelic variants can also be associated with related reproductive disorders. Case description: A missense homozygous variant (c.890G>T p.R297L) in KISS1R was identified in a child who presented with microphallus and bilateral cryptorchidism...
February 14, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29447759/ecomorphological-analysis-of-bovid-mandibles-from-laetoli-tanzania-using-3d-geometric-morphometrics-implications-for-hominin-paleoenvironmental-reconstruction
#17
Frances L Forrest, Thomas W Plummer, Ryan L Raaum
The current study describes a new method of mandibular ecological morphology (ecomorphology). Three-dimensional geometric morphometrics (3D GM) was used to quantify mandibular shape variation between extant bovids with different feeding preferences. Landmark data were subjected to generalized Procrustes analysis (GPA), principal components analysis (PCA), and discriminant function analysis (DFA). The PCA resulted in a continuum from grazers to browsers along PC1 and DFA classified 88% or more of the modern specimens to the correct feeding category...
January 2018: Journal of Human Evolution
https://www.readbyqxmd.com/read/29424783/repeat-testing-of-low-level-hiv-1-rna-assay-performance-and-implementation-in-clinical-trials
#18
Kirsten White, Will Garner, Lilian Wei, Joseph J Eron, Lijie Zhong, Michael D Miller, Hal Martin, Andrew Plummer, Cecilia Tran-Muchowski, Kim Lindstrom, James Porter, David Piontkowsky, Angela Light, Heinz Reiske, Erin Quirk
OBJECTIVE: Assess the performance of HIV-1 RNA repeat testing of stored samples in cases of low-level viremia during clinical trials. DESIGN: Prospective and retrospective analysis of randomized clinical trial samples and reference standards. METHODS: To evaluate assay variability of the Cobas AmpliPrep/Cobas TaqMan HIV-1 Test, v2.0, three separate sources of samples were utilized: the World Health Organization (WHO) HIV reference standard (assayed using 50 independent measurements at six viral loads <200 copies/ml), retrospective analysis of four to six aliquots of plasma samples from four clinical trial participants, and prospective repeat testing of 120 samples from participants in randomized trials with low-level viremia...
February 8, 2018: AIDS
https://www.readbyqxmd.com/read/29388206/fraction-and-incidence-of-liver-cancer-attributable-to-hepatitis-b-and-c-viruses-worldwide
#19
Delphine Maucort-Boulch, Catherine de Martel, Silvia Franceschi, Martyn Plummer
High-quality data on liver cancers by probable cause are scarce in many regions of the world. The United Nations recently set a goal of eliminating viral hepatitis as a major public health threat by 2030. We aimed to estimate the number of new cases of cancers attributable to hepatitis B virus (HBV) and hepatitis C virus (HCV) at a global, regional and country level, and by development status. We used data on the prevalence of HBV and HCV in hepatocellular carcinoma from a systematic review including 119 000 cases in 260 studies covering 50 countries...
January 31, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29381450/evidence-for-sexual-reproduction-identification-frequency-and-spatial-distribution-of-venturia-effusa-pecan-scab-mating-type-idiomorphs
#20
Carolyn Young, Clive Bock, Nikki Charlton, Chakradhar Mattupalli, Nick D Krom, Joanna K Bowen, Matt David Templeton, Kim Plummer, Bruce W Wood
Venturia effusa (syn. Fusicladium effusum), causal agent of pecan scab, is the most prevalent pathogen of pecan (Carya illinoinensis) causing severe yield losses in the southeastern U.S.A. Venturia effusa is currently known only by its asexual (conidial) stage. However, the degree and distribution of genetic diversity observed within and among populations of V. effusa are typical of a sexually reproducing fungal pathogen, and comparable to other Dothideomycetes with a known sexual stage, including the closely related apple scab pathogen, V...
January 30, 2018: Phytopathology
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