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https://www.readbyqxmd.com/read/28205248/a-framework-for-transition-to-specialty-practice-programs
#1
Julia Morphet, Virginia Plummer, Bridie Kent, Julie Considine
AIM: To develop a framework for emergency nursing transition to specialty practice programs. BACKGROUND: Transition to Specialty Practice programs were introduced to fill workforce shortages and facilitate the transition of nurses to specialty nursing practice. These programs are recognised as essential preparation for emergency nurses. Emergency nursing Transition to Specialty Practice programs have developed in an ad hoc manner and as a result, program characteristics vary...
February 15, 2017: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/28197316/design-and-synthesis-of-novel-selective-gpr40-agopams
#2
Christopher W Plummer, Matthew J Clements, Helen Chen, Murali Rajagopalan, Hubert Josien, William K Hagmann, Michael Miller, Maria E Trujillo, Melissa Kirkland, Daniel Kosinski, Joel Mane, Michele Pachanski, Boonlert Cheewatrakoolpong, Andrew F Nolting, Robert Orr, Melodie Christensen, Louis-Charles Campeau, Michael J Wright, Randal Bugianesi, Sarah Souza, Xiaoping Zhang, Jerry Di Salvo, Adam B Weinglass, Richard Tschirret-Guth, Ravi Nargund, Andrew D Howard, Steven L Colletti
GPR40 is a G-protein-coupled receptor expressed primarily in pancreatic islets and intestinal L-cells that has been a target of significant recent therapeutic interest for type II diabetes. Activation of GPR40 by partial agonists elicits insulin secretion only in the presence of elevated blood glucose levels, minimizing the risk of hypoglycemia. GPR40 agoPAMs have shown superior efficacy to partial agonists as assessed in a glucose tolerability test (GTT). Herein, we report the discovery and optimization of a series of potent, selective GPR40 agoPAMs...
February 9, 2017: ACS Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/28174148/local-anesthesia-versus-local-anesthesia-and-conscious-sedation-for-inguinal-hernioplasty-protocol-of-a-randomized-controlled-trial
#3
Pierre-Anthony Leake, Patrick J Toppin, Marvin Reid, Joseph M Plummer, Patrick O Roberts, Hyacinth Harding-Goldson, Michael E McFarlane
BACKGROUND: Conscious sedation is regularly used in ambulatory surgery to improve patient outcomes, in particular patient satisfaction. Reports suggest that the addition of conscious sedation to local anesthesia for inguinal hernioplasty is safe and effective in improving patient satisfaction. No previous randomized controlled trial has assessed the benefit of conscious sedation in this regard. OBJECTIVE: To determine whether the addition of conscious sedation to local anesthesia improves patient satisfaction with inguinal hernioplasty...
February 7, 2017: JMIR Research Protocols
https://www.readbyqxmd.com/read/28168002/hepatitis-c-virus-seroprevalence-in-the-general-female-population-of-9-countries-in-europe-asia-and-africa
#4
Gary M Clifford, Tim Waterboer, Bolormaa Dondog, You Lin Qiao, Dimitri Kordzaia, Doudja Hammouda, Namory Keita, Nahid Khodakarami, Syed Ahsan Raza, Ang Tshering Sherpa, Witold Zatonski, Michael Pawlita, Martyn Plummer, Silvia Franceschi
BACKGROUND: New oral treatments with very high cure rates have the potential to revolutionize global management of hepatitis C virus (HCV), but population-based data on HCV infection are missing in many low and middle-income countries (LMIC). METHODS: Between 2004 and 2009, dried blood spots were collected from age-stratified female population samples of 9 countries: China, Mongolia, Poland, Guinea, Nepal, Pakistan, Algeria, Georgia and Iran. HCV antibodies were detected by a multiplex serology assay using bead-based technology...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28164403/exploring-resilience-in-chinese-nurses-a-cross-sectional-study
#5
Yu-Fang Guo, Wendy Cross, Virginia Plummer, Louisa Lam, Yuan-Hui Luo, Jing-Ping Zhang
AIMS: To explore the state of resilience and its predictors among nurses in mainland China. BACKGROUND: Resilience is considered as an important ability to influence the prevention of job dissatisfaction and burnout. There are few studies on resilience in Chinese nurses, particularly investigating the predictors of resilience. METHODS: A cross-sectional survey was employed and 1061 nurses from six three-level hospitals in Hunan responded to participate in the study...
February 6, 2017: Journal of Nursing Management
https://www.readbyqxmd.com/read/28161766/staff-and-patient-experiences-of-decision-making-about-continuous-observation-in-psychiatric-hospitals
#6
Kirsten Barnicot, Bryony Insua-Summerhayes, Emily Plummer, Alice Hart, Chris Barker, Stefan Priebe
PURPOSE: Continuous observation of psychiatric inpatients aims to protect those who pose an acute risk of harm to self or others, but involves intrusive privacy restrictions. Initiating, conducting and ending continuous observation requires complex decision-making about keeping patients safe whilst protecting their privacy. There is little published guidance about how to balance privacy and safety concerns, and how staff and patients negotiate this in practice is unknown. To inform best practice, the present study, therefore, aimed to understand how staff and patients experience negotiating the balance between privacy and safety during decision-making about continuous observation...
February 4, 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/28148792/targeting-vaccine-induced-extrafollicular-pathway-of-b-cell-differentiation-improves-rabies-post-exposure-prophylaxis
#7
Shannon L Haley, Evgeni P Tzvetkov, Samantha Meuwissen, Joseph R Plummer, James P McGettigan
: Vaccine-induced B cells differentiate along two pathways. The follicular pathway gives rise to germinal centers (GCs) that can take weeks to fully develop. The extrafollicular pathway gives rise to short-lived plasma cells (PCs) that can rapidly secrete protective antibodies within days of vaccination. Rabies virus (RABV) post-exposure prophylaxis (PEP) requires rapid vaccine-induced humoral immunity for protection. Therefore, we hypothesized that targeting extrafollicular B cell responses for activation would improve the speed and magnitude of RABV PEP...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28129252/optimal-diagnostic-thresholds-for-diagnosis-of-orthostatic-hypotension-with-a-sit-to-stand-test
#8
Brett H Shaw, Emily M Garland, Bonnie K Black, Sachin Y Paranjape, Cyndya A Shibao, Luis E Okamoto, Alfredo Gamboa, André Diedrich, W Dale Plummer, William D Dupont, Italo Biaggioni, David Robertson, Satish R Raj
OBJECTIVE: This study aimed to identify optimal blood pressure cut-offs to diagnose orthostatic hypotension during a sit-to-stand manoeuvre. METHODS: This was a cross-sectional study of patients and healthy controls from the Vanderbilt Autonomic Dysfunction Center. Blood pressure was measured while supine, seated and standing. Blood pressure changes were calculated from supine-to-standing and seated-to-standing. Orthostatic hypotension was diagnosed on the basis of a supine-to-standing SBP drop at least 20 mmHg or a DBP drop at least 10 mmHg...
January 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28128981/development-and-assessment-of-a-novel-canine-ex-vivo-corneal-model
#9
Laura R Proietto, R David Whitley, Dennis E Brooks, Gregory E Schultz, Daniel J Gibson, William M Berkowski, Marc E Salute, Caryn E Plummer
PURPOSE: To develop a novel ex vivo extended culture model of canine corneal epithelial cell wound healing. MATERIALS AND METHODS: Canine corneoscleral rims (CSR) were obtained and, after preparation for culture, were placed on a nutating scaffold and incubated in physiological conditions. In experiment 1, eight CSR in a serum-containing antimicrobial-fortified medium were monitored for epithelial integrity and bacterial infection up to 28 days in culture. CSR were assessed histologically at the end of the culture period end points 0, 7, 14, and 28 days with accompanying scanning electron microscopic (SEM) and transmission electron microscopic (TEM) evaluation...
January 27, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28112587/the-effects-of-gender-flow-and-video-game-experience-on-combat-identification-training
#10
John Paul Plummer, David Schuster, Joseph R Keebler
The present study examined the effects of gender, video game experience (VGE), and flow state on multiple indices of combat identification (CID) performance. Individuals were trained on six combat vehicles in a simulation, presented through either a stereoscopic or non-stereoscopic display. Participants then reported flow state, VGE and were tested on their ability to discriminate friend vs. foe and identify both pictures and videos of the trained vehicles. The effect of stereoscopy was not significant. There was an effect of gender across three dependent measures...
January 23, 2017: Ergonomics
https://www.readbyqxmd.com/read/28108139/emergency-department-waiting-room-nurse-role-a-key-informant-perspective
#11
Innes Kelli, Jackson Debra, Plummer Virginia, Elliott Doug
BACKGROUND: Emergency departments have become overcrowded with increased waiting times. Strategies to decrease waiting times include time-based key performance indicators and introduction of a waiting room nurse role. The aim of the waiting room nurse role is to expedite care by assessing and managing patients in the waiting room. There is limited literature examining this role. METHODS: This paper presents results of semi-structured interviews with five key informants to explore why and how the waiting room nurse role was implemented in Australian emergency departments...
January 17, 2017: Australasian Emergency Nursing Journal: AENJ
https://www.readbyqxmd.com/read/28089366/limited-reduction-in-uremic-solute-concentrations-with-increased-dialysis-frequency-and-time-in-the-frequent-hemodialysis-network-daily-trial
#12
Tammy L Sirich, Kara Fong, Brett Larive, Gerald J Beck, Glenn M Chertow, Nathan W Levin, Alan S Kliger, Natalie S Plummer, Timothy W Meyer
The Frequent Hemodialysis Network Daily Trial compared conventional three-times weekly treatment to more frequent treatment with a longer weekly treatment time in patients receiving in-center hemodialysis. Evaluation at one year showed favorable effects of more intensive treatment on left ventricular mass, blood pressure, and phosphate control, but modest or no effects on physical or cognitive performance. The current study compared plasma concentrations of uremic solutes in stored samples from 53 trial patients who received three-times weekly in-center hemodialysis for an average weekly time of 10...
January 12, 2017: Kidney International
https://www.readbyqxmd.com/read/28088611/lactobacillus-paracasei-modulates-lps-induced-inflammatory-cytokine-release-by-monocyte-macrophages-via-the-up-regulation-of-negative-regulators-of-nf-kappab-signaling-in-a-tlr2-dependent-manner
#13
Ke-Yi Sun, Dong-Hua Xu, Chao Xie, Susan Plummer, James Tang, Xiao Fan Yang, Xiao Hui Ji
The application of the probiotic lactobacillus is suggested in the treatment of some inflammatory diseases of intestines due to its potential ability to attenuate inflammation. However, the mechanism is not completely understood. In PBMCs, Lactobacillus paracasei (L. Paracasei) down-regulated the LPS-induced production of TNF-α and IL-6. Using a macrophage-like differentiated THP-1 cell line induced by PMA, we investigated the effect of L. paracasei on the production of pro-inflammatory cytokines by monocyte-macrophages...
January 12, 2017: Cytokine
https://www.readbyqxmd.com/read/28086845/the-social-determinants-of-tuberculosis-treatment-adherence-in-a-remote-region-of-papua-new-guinea
#14
Tanya Diefenbach-Elstob, David Plummer, Robert Dowi, Sinba Wamagi, Bisato Gula, Keyanato Siwaeya, Daniel Pelowa, Peter Siba, Jeffrey Warner
BACKGROUND: Papua New Guinea (PNG) is a diverse and culturally-rich country with severe infrastructural and health problems. Tuberculosis (TB) is widespread, and the number of cases with drug resistance is rising. Treatment adherence is known to be important for both effective treatment and limiting the emergence of drug resistance. The aim of this study was to construct a matrix of the factors that act as facilitators or barriers to TB treatment adherence in a remote region of PNG. METHODS: The study was based in the Balimo region of the Western Province...
January 13, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28067909/smchd1-mutations-associated-with-a-rare-muscular-dystrophy-can-also-cause-isolated-arhinia-and-bosma-arhinia-microphthalmia-syndrome
#15
Natalie D Shaw, Harrison Brand, Zachary A Kupchinsky, Hemant Bengani, Lacey Plummer, Takako I Jones, Serkan Erdin, Kathleen A Williamson, Joe Rainger, Alexei Stortchevoi, Kaitlin Samocha, Benjamin B Currall, Donncha S Dunican, Ryan L Collins, Jason R Willer, Angela Lek, Monkol Lek, Malik Nassan, Shahrin Pereira, Tammy Kammin, Diane Lucente, Alexandra Silva, Catarina M Seabra, Colby Chiang, Yu An, Morad Ansari, Jacqueline K Rainger, Shelagh Joss, Jill Clayton Smith, Margaret F Lippincott, Sylvia S Singh, Nirav Patel, Jenny W Jing, Jennifer R Law, Nalton Ferraro, Alain Verloes, Anita Rauch, Katharina Steindl, Markus Zweier, Ianina Scheer, Daisuke Sato, Nobuhiko Okamoto, Christina Jacobsen, Jeanie Tryggestad, Steven Chernausek, Lisa A Schimmenti, Benjamin Brasseur, Claudia Cesaretti, Jose E García-Ortiz, Tatiana Pineda Buitrago, Orlando Perez Silva, Jodi D Hoffman, Wolfgang Mühlbauer, Klaus W Ruprecht, Bart L Loeys, Masato Shino, Angela M Kaindl, Chie-Hee Cho, Cynthia C Morton, Richard R Meehan, Veronica van Heyningen, Eric C Liao, Ravikumar Balasubramanian, Janet E Hall, Stephanie B Seminara, Daniel Macarthur, Steven A Moore, Koh-Ichiro Yoshiura, James F Gusella, Joseph A Marsh, John M Graham, Angela E Lin, Nicholas Katsanis, Peter L Jones, William F Crowley, Erica E Davis, David R FitzPatrick, Michael E Talkowski
Arhinia, or absence of the nose, is a rare malformation of unknown etiology that is often accompanied by ocular and reproductive defects. Sequencing of 40 people with arhinia revealed that 84% of probands harbor a missense mutation localized to a constrained region of SMCHD1 encompassing the ATPase domain. SMCHD1 mutations cause facioscapulohumeral muscular dystrophy type 2 (FSHD2) via a trans-acting loss-of-function epigenetic mechanism. We discovered shared mutations and comparable DNA hypomethylation patterning between these distinct disorders...
February 2017: Nature Genetics
https://www.readbyqxmd.com/read/28042056/molecular-diagnosis-of-bacterial-vaginosis-does-adjustment-for-total-bacterial-load-or-human-cellular-content-improve-diagnostic-performance
#16
E L Plummer, S M Garland, C S Bradshaw, M G Law, L A Vodstrcil, J S Hocking, C K Fairley, S N Tabrizi
We investigated the utility of quantitative PCR assays for diagnosis of bacterial vaginosis and found that while the best model utilized bacterial copy number adjusted for total bacterial load (sensitivity=98%, specificity=93%, AUC=0.95[95%CI=0.93,0.97]), adjusting for total bacterial or human cell load did not consistently increase the diagnostic performance of the assays.
December 29, 2016: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/28033577/reliability-and-validity-of-the-protokinetics-movement-analysis-software-in-measuring-center-of-pressure-during-walking
#17
Robert C Lynall, Lisa A Zukowski, Prudence Plummer, Jason P Mihalik
Our purpose was to determine the validity and test-retest reliability of the Protokinetics Movement Analysis Software (PKMAS) in measuring center of pressure (COP) during walking as compared to a force plate gold standard. Twenty-five healthy participants (14 females, 11 males; age 20.0±1.5years) completed 2 testing sessions approximately 5days apart (mean=5.5±1.1 days). In each session, participants completed 16 total trials across a 6m walkway: 8 trials walking on a ProtoKinetics Zeno Walkway using PKMAS and 8 trials walking over 2 force plates arranged in an offset tandem pattern...
December 21, 2016: Gait & Posture
https://www.readbyqxmd.com/read/28029612/what-are-the-most-common-domains-of-the-core-competencies-of-disaster-nursing-a-scoping-review
#18
REVIEW
Abdullelah Al Thobaity, Virginia Plummer, Brett Williams
AIM: Scoping review was conducted to identify the most common domains of the core competencies of disaster nursing. BACKGROUND: Nurses play an essential role in all phases of disaster management. For nurses to respond competently, they must be equipped with the skills to provide comprehensive and holistic care to the populations affected by or at risk of disasters. METHODS: A scoping review was conducted using the Joanna Briggs Institute methodology...
October 28, 2016: International Emergency Nursing
https://www.readbyqxmd.com/read/28012293/female-nurses-burnout-symptoms-no-association-with-the-hypothalamic-pituitary-thyroid-hpt-axis
#19
Yufang Guo, Louisa Lam, Yuanhui Luo, Virginia Plummer, Wendy Cross, Hui Li, Yizhen Yin, Jingping Zhang
Across the world, hospital nurses experience a high level of burnout. Exploring biochemical markers of burnout could help to understand physiological changes and may provide useful evidence for preventing burnout symptoms. The current study included 94 female nurses from one Chinese third-level hospital. The Maslach Burnout Inventory-General Survey (MBI-GS) was used to investigate burnout symptoms: emotional exhaustion, cynicism, reduced professional efficacy, as well as the burnout average. The HPT axis was tested by checking blood levels of thyroid-stimulating hormone (TSH), thyroxin (T4) and triiodothyronine (T3)...
November 24, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/27992697/vista-deficiency-accelerates-the-development-of-fatal-murine-lupus-nephritis
#20
Sabrina Ceeraz, Petra A Sergent, Sean F Plummer, Alan R Schned, Dov Pechenick, Christopher M Burns, Randolph J Noelle
OBJECTIVES: The targeting of negative checkpoint regulators (NCRs) as a means of augmenting anti-tumor immune responses is now an increasingly utilized and remarkably effective approach to the treatment of several human malignancies. The NCR VISTA (V-domain Ig suppressor of T cell activation, PD-1H, DD1α) suppresses T cell responses and regulates myeloid activities. We proposed that exploitation of the VISTA pathway is a novel strategy for the treatment of human autoimmune disease and therefore studied the impact of VISTA genetic deficiency on lupus development in a lupus-prone mouse strain...
December 19, 2016: Arthritis & Rheumatology
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